Journal of Veterinary Pharmacology and Therapeutics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Comparison of florfenicol pharmacokinetics in Exopalaemon carinicauda at different temperatures and administration routes
AbstractFlorfenicol is a broad ‐spectrum antibacterial drug.Exopalaemon carinicauda is important in the prawn aquaculture industry in China. Florfenicol pharmacokinetics inE.  carinicauda were studied at different temperatures andvia different routes of administration to provide a scientific basis for the rational use of drugs forE. carinicauda production. At water temperatures of 22  ± 0.4°C and 28 ± 0.3°C, after intramuscular (IM) injection and oral (per ora (PO)) administration of florfenicol at 10  mg/kg body weight (BW) and 30 mg/kg BW, respectively, the florfenicol concentration in the plasma, hepatopan...
Source: Journal of Veterinary Pharmacology and Therapeutics - November 28, 2018 Category: Veterinary Research Authors: Yanyan Feng, Qianqian Zhai, Jiajia Wang, Jitao Li, Jian Li Tags: ORIGINAL ARTICLE Source Type: research

Pharmacokinetics and bioavailability of danofloxacin in chukar partridge (Alectoris chukar) following intravenous, intramuscular, subcutaneous, and oral administrations
AbstractThe aim of the present study was to determine the pharmacokinetics (PKs) and bioavailability of danofloxacin in chukar partridge (Alectoris chukar) following intravenous (IV), intramuscular (IM), subcutaneous (SC), and oral (PO) administrations at a dose of 10  mg/kg. A total of eight clinically healthy chukar partridges weighing 480 ± 45 g were used for the investigation. The study was performed in a crossover design (2 × 2 × 2 × 2) with a 15‐day washout period between two administrations in four periods. The plasma concentrations of dano floxacin were determined using reversed‐phase high‐perfo...
Source: Journal of Veterinary Pharmacology and Therapeutics - November 25, 2018 Category: Veterinary Research Authors: Orhan Corum, Duygu Durna Corum, Orkun Atik, Hatice Eser Faki, Feray Altan, Kamil Uney Tags: ORIGINAL ARTICLE Source Type: research

Comparative single ‐dose pharmacokinetics of orally administered florfenicol in rainbow trout (Oncorhynchus mykiss, Walbaum, 1792) at health and experimental infection with Streptococcus iniae or Lactococcus garvieae
In conclusion, infection with these bacteria can affect the pharmacokinetic behavior of florfenicol in rainbow trouts as shown by decreased bioavailability and increased total body clearance and volume of distribution inL.  garvieae infection and decreased volume of distribution accompanied by increasedCmax inS.  iniae‐infected fish. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 25, 2018 Category: Veterinary Research Authors: Nima Shiry, Tahoora Shomali, Siyavash Soltanian, Mostafa Akhlaghi Tags: ORIGINAL ARTICLE Source Type: research

Modulations of bovine hepatic microsomal metabolism of benzimidazoles by secondary plant metabolites
AbstractThe study was aimed to estimate the effect of plant secondary metabolites present in ruminants diet and phytogenic feed additives on liver microsomal metabolism of albendazole and fenbendazole. The selected phytocompounds comprised of flavonoids (apigenin, quercetin) and saponins (hederagenin, medicagenic acid). The experiments were performed on liver microsomal fraction obtained from routinely slaughtered cows. The intensity of albendazole and fenbendazole metabolism in the presence of flavonoids and saponins was analyzed in equimolar concentration (100  μM). The obtained results revealed that both flavonoids an...
Source: Journal of Veterinary Pharmacology and Therapeutics - November 25, 2018 Category: Veterinary Research Authors: Wojciech Karlik, Magdalena Ch łopecka, Magdalena Bamburowicz‐Klimkowska, Marta Mendel Tags: ORIGINAL ARTICLE Source Type: research

The α2A‐adrenoceptor subtype plays a key role in the analgesic and sedative effects of xylazine
AbstractXylazine, the classical α2‐adrenoceptor (α2‐AR) agonist, is still used as an analgesic and sedative in veterinary medicine, despite its low potency and affinity for α2‐ARs. Previous pharmacological studies suggested that the α2A‐AR subtype plays a role in mediating the clinical effects of xylazine; however, these studies were hampered by the poor subtype‐selectivity of the antagonists used and a lack of knowledge of their bioavailability in vivo. Here, we attempted to elucidate the role of the α2A‐AR subtype in mediating the clinical effects of xylazine by comparing the analgesic and sedative effec...
Source: Journal of Veterinary Pharmacology and Therapeutics - November 11, 2018 Category: Veterinary Research Authors: Taisuke Kitano, Takeshi Kobayashi, Soichiro Yamaguchi, Ken ‐ichi Otsuguro Tags: SHORT COMMUNICATION Source Type: research

Pharmacokinetic/pharmacodynamic integration of cefquinome against Pasteurella Multocida in a piglet tissue cage model
In conclusion, cefquinome exhibited a potent antibacterial effect againstP.  multocida. When %T  >  MIC reached 73.44%, cefquinome exhibited a bactericidal effect againstP.  multocida after three successive daily administrations. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 8, 2018 Category: Veterinary Research Authors: Longfei Zhang, Xun Wu, Zilong Huang, Zheng Kang, Yuqin Chen, Xiangguang Shen, Qinren Cai, Huanzhong Ding Tags: ORIGINAL ARTICLE Source Type: research

The pharmacokinetics of moxidectin following intravenous and topical administration to swine
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 5, 2018 Category: Veterinary Research Authors: Hongzhi Xiao, Haoyuan Peng, Ting Zhao, Jingyuan kong, Jiao Xue, Jianzhong Wang, Yalong Lin, Suxia zhang, Xingyuan Cao Source Type: research

Pharmacokinetics of ketorolac in wild Eastern box turtles (Terrapene carolina carolina) after single intramuscular administration
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 5, 2018 Category: Veterinary Research Authors: Anthony J. Cerreta, Chris A. Masterson, Gregory A. Lewbart, Delta R. Dise, Mark G. Papich Source Type: research

Issue Information
Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 6, Page i-iv, December 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 2, 2018 Category: Veterinary Research Source Type: research

Dr. Steeve Gigu ère (May 31, 1969–May 27, 2018)
Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 6, Page 924-924, December 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 2, 2018 Category: Veterinary Research Source Type: research

Evaluation of plasma concentration after intravenous and intramuscular penicillin administration over 24  hr in healthy adult horses
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 2, 2018 Category: Veterinary Research Authors: Jarrod T. Younkin, Elizabeth M. Santschi, Butch Kukanich, Brian V. Lubbers, Matthew Warner Source Type: research

Mycophenolic acid in patients with immune ‐mediated inflammatory diseases: From humans to dogs
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - October 30, 2018 Category: Veterinary Research Authors: Michael Klotsman, Gayatri Sathyan, Wayne H. Anderson, Oliver A. Garden, Padmaja Shivanand Source Type: research

Pharmacokinetics of sanguinarine, chelerythrine, and their metabolites in broiler chickens following oral and intravenous administration
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - October 23, 2018 Category: Veterinary Research Authors: Nan ‐Xi Hu, Mei Chen, Yi‐Song Liu, Qi Shi, Bo Yang, Huan‐Cheng Zhang, Pi Cheng, Qi Tang, Zhao‐Ying Liu, Jian‐Guo Zeng Source Type: research

Tamoxifen induces apoptosis and inhibits respiratory burst in equine neutrophils independently of estrogen receptors
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - October 22, 2018 Category: Veterinary Research Authors: Carla Olave, Pamela Alvarez, Benjamin Uberti, Natalia Morales, Claudio Henriquez, Hugo Folch, Jose Sarmiento, Gabriel Moran Source Type: research

Pharmacokinetics of ceftriaxone in Green sea turtles (Chelonia mydas) following intravenous and intramuscular administration at two dosages
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - October 11, 2018 Category: Veterinary Research Authors: Roipim Mapongpeng, Weerapong Laovechprasit, Amnart Poapolathep, Mario Giorgi, Chalatip Junchompoo, Chainarong Sakulthaew, Usuma Jermnak, Wanida Passadurak, Saranya Poapolathep Source Type: research