Journal of the Association for Laboratory AutomationThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

Read news and analysis about clinical lab software and the clinical lab industry at the most widely read lab blog - Lab Soft News.

• Contents
• Discussions

Pages: 1  2  

JALA Information for authorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - November 16, 2009 Category: Laboratory Medicine Tags: Meetings and Events Source Type: journals

World NewsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Exoscan portable FTIR spectrometer system now offers increased sampling and usability capabilities that extend its capability to an array of applications for lab and/or field use. New sampling interfaces for the Exoscan system include internal reflectance, grazing angle reflectance, diffuse reflectance, and specular reflectance. With these enhancements, Exoscan can accommodate liquids, powders, pastes, and reflective and nonreflective solids. (Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - November 16, 2009 Category: Laboratory Medicine Tags: World News Source Type: journals

Please Do Pay Attention to the Man Behind the CurtainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
“…ALA is an impressive best practices model from which other associations and professional societies learn.” (Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - November 16, 2009 Category: Laboratory Medicine Authors: Erik Rubin Tags: From the President Source Type: journals

Changes, Challenges, and ChoicesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
“ALA and JALA have become the intersection at which the vitality of like minds not only connects, but combusts and creates.” (Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - November 16, 2009 Category: Laboratory Medicine Authors: Dean Ho Tags: From the Editor-in-Chief Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - November 16, 2009 Category: Laboratory Medicine Tags: Frontmatter Source Type: journals

Table of ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - November 16, 2009 Category: Laboratory Medicine Tags: Frontmatter Source Type: journals

Subject IndexEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - November 16, 2009 Category: Laboratory Medicine Tags: Meetings and Events Source Type: journals

Author IndexEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - November 16, 2009 Category: Laboratory Medicine Tags: Meetings and Events Source Type: journals

Meetings and EventsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
December 5–8 2009 ASH Annual Meeting: New Orleans, LA (Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - November 16, 2009 Category: Laboratory Medicine Tags: Meetings and Events Source Type: journals

A Microfluidic Cartridge System for Multiplexed Clinical AnalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cartridge-based microfluidics is a promising technology for clinical diagnostics. By miniaturizing the fluid-handling processes required for genomic and proteomic analyses, reagent and specimen volume is minimized along with the size of the system. We demonstrate an automated microfluidic system capable of performing six multiplexed genomic and proteomic analyses simultaneously, by means of an integrated electrochemical sensor and embedded controls. (Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - November 16, 2009 Category: Laboratory Medicine Authors: Walson Lawi, Chris Wiita, Steven T. Snyder, Fang Wei, David Wong, Pak Kin Wong, Joseph C. Liao, David Haake, Vincent Gau Tags: Technology Review Source Type: journals

Iridium Oxide Nanomonitors for Real-time Health Monitoring SystemsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An innovative lab-on-a-chip device based on iridium oxide (IrOx) nanowires was designed, fabricated, and developed for real-time “point-of-care” diagnostics. The turnaround time in detection and the need for expensive equipment for analysis have considverably limited rapid and “point-of-care” diagnosis. This research demonstrates the potential of IrOx nanowires toward early disease diagnosis by detecting proteins that are disease markers. The device designed is based on electrical detection of protein biomarkers wherein a single capture immunoassay is built onto a vertically aligned IrOx nanowire platform. Detectio...
Source: Journal of the Association for Laboratory Automation - November 16, 2009 Category: Laboratory Medicine Authors: Vinu L. Venkatraman, Fengyan Zhang, David Evans, Bruce Ulrich, Shalini Prasad Tags: Original Reports Source Type: journals

Analysis of Retina and Erythrocyte Glycerophospholipid Alterations in a Rat Model of Type 1 DiabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An automated tandem mass spectrometry–based analysis using precursor ion and neutral loss scans in a triple quadrupole (QqQ) mass spectrometer has been used to identify and quantify changes in the abundances of glycerophospholipids extracted from retina and erythrocytes in a rat streptozotocin model of type 1 diabetes, 6 and 36 weeks after the induction of diabetes, compared with age-matched nondiabetic controls. The utility of an “internal standard” method compared with an “internal standard free” method for quantification of differences in the abundances of specific lipid ions was evaluated in both retina and e...
Source: Journal of the Association for Laboratory Automation - November 16, 2009 Category: Laboratory Medicine Authors: Todd A. Lydic, Rebecca Renis, Julia V. Busik, Gavin E. Reid Tags: Original Reports Source Type: journals

Pathway Reporter Assays Reveal Small Molecule Mechanisms of ActionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cell-based, phenotypic screening of small molecules often identifies compounds with provocative biological properties. However, determining the cellular target(s) and/or mechanism of action (MoA) of lead compounds remains an extremely challenging and time-consuming exercise. To provide insights into a compound's cellular action and greatly reduce the time required for MoA determination, we have developed a screening platform consisting of an extensive series of reporter gene assays (RGAs). A collection of >11,000 compounds of known MoA (e.g., World Drug Index entries) were screened against the entire panel. The output prov...
Source: Journal of the Association for Laboratory Automation - November 16, 2009 Category: Laboratory Medicine Authors: Frederick J. King, Douglas W. Selinger, Felipa A. Mapa, Jeff Janes, Hua Wu, Timothy R. Smith, Qing-Yin Wang, Pornwaratt Niyomrattanakitand, Daniel G. Sipes, Achim Brinker, Jeffrey A. Porter, Vic E. Myer Tags: Original Reports Source Type: journals

High-Pressure/High-Temperature Microreactors for Nanostructure SynthesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe continuous synthesis of nanostructures in microfluidic systems consisting of multiple sub–millimeter-sized channels in which fluid flows continuously and chemical reactions take place. The small reaction volumes combined with the high heat and mass transfer rates enable reactions to be performed under more controlled conditions with higher yields than can typically be achieved with conventional reactors. Moreover, manipulation of reaction parameters, while the reaction proceeds, allows optimization of synthesis conditions. The ability to work at elevated temperatures and pressures while confining potentially ...
Source: Journal of the Association for Laboratory Automation - November 16, 2009 Category: Laboratory Medicine Authors: Samuel Marre, Jinyoung Baek, Jongnam Park, Moungi G. Bawendi, Klavs F. Jensen Tags: Original Reports Source Type: journals

Automation of the SomaLogic Proteomics Assay: A Platform for Biomarker DiscoveryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
At SomaLogic, we have embarked on an ambitious program of clinical studies using a novel aptamer-based proteomics technology to discover biomarkers and develop new tools to diagnose, understand, and treat human disease. As part of this program, we designed and implemented an automated assay for its highly multiplexed proteomics discovery platform. The performance of the automated assay was validated in a study that compared the automated assay to the specifications of an established manual method. Results showed that the automated method performed to the required specifications, and that the automation system improved the ...
Source: Journal of the Association for Laboratory Automation - November 16, 2009 Category: Laboratory Medicine Authors: Tracy R. Keeney, Christopher Bock, Larry Gold, Stephan Kraemer, Bridget Lollo, Malti Nikrad, Martin Stanton, Alex Stewart, Jonathan D. Vaught, Jeffrey J. Walker Tags: Original Reports Source Type: journals

A Method for Identifying Small-Molecule Aggregators Using Photonic Crystal Biosensor MicroplatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Small molecules identified through high-throughput screens are an essential element in pharmaceutical discovery programs. It is now recognized that a substantial fraction of small molecules exhibit aggregating behavior leading to false positive results in many screening assays, typically due to nonspecific attachment to target proteins. Therefore, the ability to efficiently identify compounds within a screening library that aggregate can streamline the screening process by eliminating unsuitable molecules from further consideration. In this work, we show that photonic crystal (PC) optical biosensor microplate technology ca...
Source: Journal of the Association for Laboratory Automation - November 16, 2009 Category: Laboratory Medicine Authors: Leo L. Chan, Erich A. Lidstone, Kristin E. Finch, James T. Heeres, Paul J. Hergenrother, Brian T. Cunningham Tags: Original Reports Source Type: journals

Backscattering Interferometry for Low Sample Consumption Molecular Interaction ScreeningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Backscattering interferometry (BSI), which uses a simple optical train comprising a He–Ne laser, a microfluidic channel, and a position sensor, has now enabled the measurement of both tethered and free-solution, label-free, molecular interactions within just nanoliters of sample. The simple macro-to-micro interface allows for a highly efficient assay work flow, which has been used to interrogate molecular binding interactions between proteins, ions and protein, and small molecules and proteins, with a high dynamic range of dissociation constants (KD) and unmatched sensitivity. With this technique, the equilibrium KD for ...
Source: Journal of the Association for Laboratory Automation - November 16, 2009 Category: Laboratory Medicine Authors: Amanda Kussrow, Carolyn S. Enders, Ereny F. Morcos, Darryl J. Bornhop Tags: Original Reports Source Type: journals

Perspectives on Utilizing Unique Features of Microfluidics Technology for Particle and Cell SortingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we use recent examples from our work to illustrate the potential of microfluidic cell- and particle-sorting devices. We demonstrate the potential of chip-based high-gradient magnetophoresis that enable high-purity separation through reversible trapping of target particles paired with high-stringency washing with minimal loss. We also describe our work in the development of devices that perform simultaneous multitarget sorting, either through precise control of magnetic and fluidic forces or through the integration of multiple actuation forces into a single monolithic device. We believe that such devices may...
Source: Journal of the Association for Laboratory Automation - November 16, 2009 Category: Laboratory Medicine Authors: Jonathan D. Adams, H. Tom Soh Tags: Original Reports Source Type: journals

Automation Highlights from the LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Automated semipreparative LC/MS systems are now well established commercially and commonly used for purification of early stage drug discovery compounds. A number of vendors have instruments on the market that are capable of reliably purifying compounds with good water/acetonitrile solubility. However, these systems often fail when the sample has poor solubility, extreme polarity, and/or poor ionization. Even in cases when substantial optimization has been done before purification, a certain percent of failures to recover the desired product is unavoidable. In the past, when most of the samples run on LC/MS semipreparative...
Source: Journal of the Association for Laboratory Automation - November 16, 2009 Category: Laboratory Medicine Authors: Kerstin Thurow, Hilmar Weinmann Tags: Literature Highlights Source Type: journals

JALA Information for authorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - September 7, 2009 Category: Laboratory Medicine Tags: Meetings and Events Source Type: journals

World NewsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
According to Aalborg, its new TPU tube pumps are ideally suited for liquids of low-to-medium viscosity. Chemically resistant tubing materials and new peristaltic pump head technology combine to meet the demands for reliable, long-term pump operation. Four stainless steel rollers (eight roller option is available) minimize pulsation and promote longer tube life. (Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - September 7, 2009 Category: Laboratory Medicine Tags: World News Source Type: journals

Reaching Around the WorldEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
When ALA adopted its strategic plan in 2008, one important initiative was to advance the science and education of laboratory automation through the continued development of our organization's global identity, reach, and influence. Since then, the ALA Board of Directors and staff have worked to expand existing and cultivate new strategic relationships with targeted organizations and thought leaders. Progress has been impressive and productive and, as planned and hoped, is encouraging the amalgamation of ALA among key industries, academia, government, and continents. (Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - September 7, 2009 Category: Laboratory Medicine Authors: Erik Rubin Tags: From the President Source Type: journals

Wow, This is Great!Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
I've been on the job as the JALA editor-in-chief for almost a year already, and one of the most satisfying things about it is how often I hear praise and surprise from colleagues to whom I introduce the journal. My day job takes me around the globe regularly, and regardless of whether I'm working with graduate students in our laboratory at Northwestern University, dining with colleagues at Taiwan University, making a presentation to scholars in St. Petersburg, Russia, connecting with nanodiamond specialists in Los Angeles, meeting dignitaries at the University of Beijing, or struggling with 100-degree heat and unreliable I...
Source: Journal of the Association for Laboratory Automation - September 7, 2009 Category: Laboratory Medicine Authors: Dean Ho Tags: From the Editor-in-Chief Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - September 7, 2009 Category: Laboratory Medicine Tags: Frontmatter Source Type: journals

Table of ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - September 7, 2009 Category: Laboratory Medicine Tags: Frontmatter Source Type: journals

Meetings and EventsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
October 1 Molecular Pathology Essentials: Copenhagen, Denmark (Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - September 7, 2009 Category: Laboratory Medicine Tags: Meetings and Events Source Type: journals

2008 ALA Survey on Laboratory AutomationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This JALA feature story reports the results of two surveys conducted by the Association for Laboratory Automation (ALA) to evaluate the state of industrial laboratory automation. The purpose was to gain more insight into the results of the 2006 ALA survey by posing more detailed questions based on the 2006 responses. The 2008 survey polled 43 carefully selected ALA members whose organizations use laboratory automation. These organizations represented the biotech, pharmaceutical, agricultural science, consumer goods, materials and formulation, research institute, and government business sectors. The 2008 survey also polled ...
Source: Journal of the Association for Laboratory Automation - September 7, 2009 Category: Laboratory Medicine Authors: Steven D. Hamilton Tags: Feature Story Source Type: journals

High-Throughput Screening for High Affinity AntibodiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
UCB Selected Lymphocyte Antibody Method (SLAM) is a rapid and efficient process for the generation of high-quality monoclonal antibodies, in which variable region gene sequences are recovered directly from specific, single B cells. Monoclonal antibody generation has been limited in the past by the relatively low efficiency of the hybridoma process. UCB SLAM process is well suited to high-throughput screening and has been extensively automated at UCB. If necessary, in excess of 1×109 B cells can be screened in a campaign, to discover a rare therapeutic antibody candidate, which meets the stringent selection criteria. Prima...
Source: Journal of the Association for Laboratory Automation - September 7, 2009 Category: Laboratory Medicine Authors: Simon Tickle, Ralph Adams, Derek Brown, Meryn Griffiths, Daniel Lightwood, Alastair Lawson Tags: Innovation Briefs Source Type: journals

Automated Extraction of DNA from Forensic Sample Types Using the PrepFiler Automated Forensic DNA Extraction KitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The HID EVOlution–Extraction System (Tecan Group Ltd., Mannedorf, Switzerland) was developed to automate DNA extraction from biological samples using the PrepFiler Automated Forensic DNA Extraction Kit (Applied Biosystems, Foster City, CA). The system consists of a Tecan Freedom EVO 150 robot (Tecan Group Ltd., Mannedorf, Switzerland), a graphical user interface designed for use with Freedom EVOware software v 2.1 SP1 (Tecan Group Ltd., Mannedorf, Switerland) as well as instrument hardware and plastic to support the PrepFiler reagents and protocol. The DNA quality and quantity obtained were comparable to that observed wi...
Source: Journal of the Association for Laboratory Automation - September 7, 2009 Category: Laboratory Medicine Authors: Maxim Brevnov, Janna Mundt, Jacki Benfield, Lynda Treat-Clemons, Geert Kalusche, Jason Meredith, Gregory Porter, Manohar R. Furtado, Jaiprakash G. Shewale Tags: Innovation Briefs Source Type: journals

In Situ Nanoliter-Scale Polymer Fabrication for Flexible Cell PatterningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Drug-testing technologies, biosensor fabrication, tissue engineering, and basic biological research depend strongly on the patterning of live animal cells. Current techniques for controlling cellular adhesion are restricted with two primary limitations. Firstly, the complexity of the available patterns is very limited and, secondly, the pallet of materials that induce cellular patterning is exhaustible. Here, we demonstrate a method for computer-aided control of cell patterning using a scientific inkjet printer that yields a highly complex cellular pattern suitable for applications in regenerative medicine and rapid protot...
Source: Journal of the Association for Laboratory Automation - September 7, 2009 Category: Laboratory Medicine Authors: Albert R. Liberski, Rong Zhang, Mark Bradley Tags: Innovation Briefs Source Type: journals

A Flow-Through Ultrasonic Lysis Module for the Disruption of Bacterial SporesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An automated, flow-through ultrasonic lysis module that is capable of disrupting bacterial spores to increase the DNA available for biodetection is described. The system uses a flow-through chamber that allows for direct injection of the sample without the need for a chemical or enzymatic pretreatment step to disrupt the spore coat before lysis. Lysis of Bacillus subtilis spores, a benign simulant of Bacillus anthracis, is achieved by flowing the sample through a tube whose axis is parallel to the faces of two transducers that deliver 10Wcm−2 to the surface of the tube at 1.4-MHz frequency. Increases in amplifiable DNA w...
Source: Journal of the Association for Laboratory Automation - September 7, 2009 Category: Laboratory Medicine Authors: Cynthia L. Warner, Cynthia J. Bruckner-Lea, Jay W. Grate, Timothy Straub, Gerald J. Posakony, Nancy Valentine, Richard Ozanich, Leonard J. Bond, Melissa M. Matzke, Brian Dockendorff, Catherine Valdez, Patrick Valdez, Stanley Owsley Tags: Original Reports Source Type: journals

An Automated Micropositioning System for Investigating C. elegans Locomotive BehaviorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This paper presents a visually servoed micropositioning system capable of automatically extracting locomotive features of Caenorhabditis elegans online at a full 30Hz. The employment of Gaussian Pyramid Level-2 images significantly reduces the image size by 16-fold and permits real-time feature extraction, without sacrificing accuracy due to the cubic smoothing spline fitting. The automated micropositioning system is capable of revealing subtle differences in locomotive behavior across strains. A total of 128 worms of four C. elegans strains with different numbers of muscle arms were continuously tracked for 3min per samp...
Source: Journal of the Association for Laboratory Automation - September 7, 2009 Category: Laboratory Medicine Authors: Wenhui Wang, Yu Sun, Scott J. Dixon, Mariam Alexander, Peter J. Roy Tags: Original Reports Source Type: journals

Process Evaluation of a Fully Automated Molecular Diagnostics SystemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Molecular diagnostics presents challenges to clinical laboratories that are under pressure to consolidate and automate. There is a need to evaluate molecular automation for process efficiency and suitability for high-throughput environments in core laboratories.A fully automated molecular instrument platform (the BD Viper System with XTR Technology in extracted mode [BD Viper System with XTR]), was evaluated for automation efficiency, labor requirements, and system robustness. System productivity was predicted using time and motion studies as well as process simulation.Preanalytical steps required 15min of skilled operator...
Source: Journal of the Association for Laboratory Automation - September 7, 2009 Category: Laboratory Medicine Authors: Robin A. Felder, Maria L. Foster, Michael J. Lizzi, Brent R. Pohl, Dustin M. Diemert, Bryan G. Towns Tags: Original Reports Source Type: journals

Microfluidic Device for Coupling Capillary Electrophoresis and Matrix-Assisted Laser Desorption Ionization-Mass SpectrometryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We have designed and fabricated a polydimethylsiloxane (PDMS) microfluidic device for coupling capillary electrophoresis (CE) and matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS). The coupling is advantageous in biological research because CE has the power of separating analytes in a sample based on mobility difference and MALDI-MS provides accurate and sensitive mass analysis of the analytes. The goal is realized by fractionating the separated analytes inside the microfluidic device and pushing the analyte fractions into open reservoirs. Each analyte fraction is then mixed with a matrix s...
Source: Journal of the Association for Laboratory Automation - September 7, 2009 Category: Laboratory Medicine Authors: Yiqi Luo, Songyun Xu, James W. Schilling, Kenneth H. Lau, John C. Whitin, Tom T.S. Yu, Harvey J. Cohen Tags: Original Reports Source Type: journals

Automation Highlights from the LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There is a growing interest in the use of small molecules as chemical probes in parallel to classical genomic tools (gene expression, gene profiling, gene knockouts, and siRNA-based gene silencing, etc.) to understand biological functions. Small-molecule probes have the ability to modulate macromolecules, such as proteins, DNA, RNA, or carbohydrates, in a controlled, selective, and nondestructive manner. In addition to using them as chemical probes to understand biological function, these small molecules offer an excellent starting point for launching drug discovery programs and could be further developed as therapeutic ca...
Source: Journal of the Association for Laboratory Automation - September 7, 2009 Category: Laboratory Medicine Authors: Kerstin Thurow, Hilmar Weinmann Tags: Literature Highlights Source Type: journals

Instructions for AuthorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - July 7, 2009 Category: Laboratory Medicine Tags: Meetings and Events Source Type: journals

World NewsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
These new Paddle Wheel Flow Meters are designed for measuring very low liquid flow rates and for highly accurate temperature readings, considered easy to install and operate, feature one moving part, and their sapphire jewel bearings facilitate virtually friction-free impeller wheel rotations that result in linear low flow metering. Models constructed of polypropylene or chemically resistant PVDF can be mounted either horizontally or vertically. (Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - July 7, 2009 Category: Laboratory Medicine Tags: World News Source Type: journals

Social Networking: Walking the TalkEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
“…ALA leadership maintains a watchful eye to ensure that ALA members truly are benefitting from these new technology trends.” (Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - July 7, 2009 Category: Laboratory Medicine Authors: Erik Rubin Tags: From the President Source Type: journals

Automation in Food and Agricultural LaboratoriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
“ALA members share more similarities than differences, and can learn a great deal from each other.” (Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - July 7, 2009 Category: Laboratory Medicine Authors: W. Jeffrey Hurst Tags: From the Guest Editor Source Type: journals

ALA Expands Open Access to JALA Scientific ContentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
“This policy change is in direct line with ALA's mission and goals.” (Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - July 7, 2009 Category: Laboratory Medicine Authors: Dean Ho Tags: From the Editor-in-Chief Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - July 7, 2009 Category: Laboratory Medicine Tags: Frontmatter Source Type: journals

Table of contentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - July 7, 2009 Category: Laboratory Medicine Tags: Frontmatter Source Type: journals

Meetings and EventsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
August 2–7 42nd IUPAC Congress—Chemistry Solutions: Glasgow, UK (Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - July 7, 2009 Category: Laboratory Medicine Tags: Meetings and Events Source Type: journals

Countercurrent Chromatography and Countercurrent DistributionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
I read with great interest the report of Napolitano et al. in the February, 2009 issue of JALA concerning countercurrent chromatography (CCC), because I had the privilege more than 40 years ago of briefly working in the laboratory at the Rockefeller Institute (now Rockefeller University) of Dr. Lyman C. Craig, the inventor of countercurrent distribution (CCD), the predecessor technology to CCC. These two technologies are virtually identical except for the mechanical sophistication. Each system provides for sequential partitions of a solute between a stationary solvent phase and a mobile solvent phase. It is understandable...
Source: Journal of the Association for Laboratory Automation - July 7, 2009 Category: Laboratory Medicine Authors: Charles D. Hawker Tags: Letter to the Editor Source Type: journals

Advanced Technologies for Pathogen and Toxin Detection in Foods: Current Applications and Future DirectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite great strides made in the past decades, the detection of microbial pathogens and their toxins in foods remains a challenging task. This is due primarily to several inherent difficulties associated with food analysis, that is, the complexities of food matrices (inhibitors and normal flora), the attributes of target analytes in foods (low level, heterogeneous distribution, and cell injury during processing), and the ratio between the amount of food samples and the detection assay volume. This review aims to provide an overview and a better understanding of the limitations, current applications, and future perspective...
Source: Journal of the Association for Laboratory Automation - July 7, 2009 Category: Laboratory Medicine Authors: Beilei Ge, Jianghong Meng Tags: Technology Review Source Type: journals

Microbial Identification: Tracking the Great Unknown with Innovative and Advanced TechnologiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Major changes in production and distribution practices in the global food industry are prompting increased scientific efforts to identify, understand, and control the transmission of microbial contaminants. Through the development of advanced diagnostic tools, significant inroads in microbial source tracking are making important contributions to the safety of the food supply. (Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - July 7, 2009 Category: Laboratory Medicine Authors: Sarita Raengpradub Tags: Innovation Brief Source Type: journals

Rapid ID Technology (RIDT) in Plants: High-Speed DNA Fingerprinting in Grain Seeds for the Identification, Segregation, Purity, and Traceability of Varieties Using Labautomation RoboticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A rapid and inexpensive DNA diagnostic platform for fingerprinting Cdn. registered, wheat varieties has been developed. Two current, real-time applications being used in Canada include the determination of purity (% contamination) of grain shipments in rail cars and the monitoring of field plots that represent a midge varietal blend. The quantification of a sample is accomplished by fingerprinting single seeds and a sample having a mixture of varieties can be assayed. The Rapid ID Technology (RIDT) platform enables high-speed, high-throughput, robotic labautomation and low-cost single nucleotide polymorphism (SNP)-DNA fing...
Source: Journal of the Association for Laboratory Automation - July 7, 2009 Category: Laboratory Medicine Authors: J. Douglas Procunier, Suvira Prashar, Gang Chen, Danielle Wolfe, Stephen Fox, M. Liakat Ali, Mark Gray, Yi Zhou, Mike Shillinglaw, Robert Roeven, Ron DePauw Tags: Original Reports Source Type: journals

Application of Kevin–Voigt Model in Quantifying Whey Protein Adsorption on Polyethersulfone Using QCM-DEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, data recorded by a QCM-D apparatus were fitted into the Kevin–Voigt model, to quantify the whey protein adsorption on the polyethersulfone membrane surface. (Source: Journal of the Association for Laboratory Automation)
Source: Journal of the Association for Laboratory Automation - July 7, 2009 Category: Laboratory Medicine Authors: Sean X. Liu, Jun-Tae Kim Tags: Original Reports Source Type: journals

Automated Yeast Transformation Protocol to Engineer Saccharomyces cerevisiae Strains for Cellulosic Ethanol Production with Open Reading Frames That Express Proteins Binding to Xylose Isomerase Identified Using a Robotic Two-Hybrid ScreenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, an automated two-hybrid interaction protocol was used to find yeast genes encoding proteins that bind XI to identify potential targets for improving xylose utilization by S. cerevisiae. A pDEST32 vector re-engineered for TRP selection and containing the Gal4 binding domain fused with the Piromyces sp. E2 XI open reading frame (ORF) was used as bait with a library of LEU-selectable pOAD vectors containing the Gal4 activation domain in fusion with members of the S. cerevisiae genome ORF collection. Binding of a yeast ORF protein to XI activates two chromosomally located reporter genes in a PJ69-4 yeast strain ...
Source: Journal of the Association for Laboratory Automation - July 7, 2009 Category: Laboratory Medicine Authors: Stephen R. Hughes, Joseph O. Rich, Kenneth M. Bischoff, Ronald E. Hector, Nasib Qureshi, Badal C. Saha, Bruce S. Dien, Siqing Liu, John S. Jackson, David E. Sterner, Tauseef R. Butt, Joshua LaBaer, Michael A. Cotta Tags: Original Reports Source Type: journals

Automated Yeast Mating Protocol Using Open Reading Frames from Saccharomyces cerevisiae Genome to Improve Yeast Strains for Cellulosic Ethanol ProductionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Engineering the industrial ethanologen Saccharomyces cerevisiae to use pentose sugars from lignocellulosic biomass is critical for commercializing cellulosic fuel ethanol production. Approaches to engineer pentose-fermenting yeasts have required expression of additional genes. We implemented a high-throughput strategy to improve anaerobic growth on xylose and rate of ethanol production by evaluating overexpression of each native S. cerevisiae gene from a collection of haploid PJ69-4 MATa strains expressing the gene open reading frames (ORFs) mated to a haploid PJ69-4 MATalpha strain expressing the Piromyces sp.E2 xylose is...
Source: Journal of the Association for Laboratory Automation - July 7, 2009 Category: Laboratory Medicine Authors: Stephen R. Hughes, Ronald E. Hector, Joseph O. Rich, Nasib Qureshi, Kenneth M. Bischoff, Bruce S. Dien, Badal C. Saha, Siqing Liu, Elby J. Cox, John S. Jackson, David E. Sterner, Tauseef R. Butt, Joshua LaBaer, Michael A. Cotta Tags: Original Reports Source Type: journals