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134 records returned

Antihypertensive Pharmacotherapy: Adverse Effects of Medications Promote Nonadherence.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19245507 [PubMed - as supplied by publisher] (Source: Journal of the Cardiometabolic Syndrome)
Source: Journal of the Cardiometabolic Syndrome - March 1, 2009 Category: Cardiology Authors: Fergus IV Tags: J Cardiometab Syndr Source Type: journals

Statin Pleiotropy Against Renal Injury.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Statins may exhibit significant renoprotective effects beyond their lipid-lowering capacity. Herein, the authors review data from human and animal models of renal disease as well as from studies in cultured renal cells with regard to extralipid renoprotective properties of statins. Statins may exert lipid-independent benefits against renal injury in experimental states of chronic or acute renal function impairment. These include diabetic and hypertensive glomerulosclerosis, autoimmune glomerulonephritis, ischemia/reperfusion-induced renal damage, and unilateral ureteral obstructive nephropathy. Also, statins, by reduci...
Source: Journal of the Cardiometabolic Syndrome - March 1, 2009 Category: Cardiology Authors: Kostapanos MS, Liberopoulos EN, Elisaf MS Tags: J Cardiometab Syndr Source Type: journals

When the Heart and the Mind Collide: Cardiovascular Risk Factors and Antipsychotic Use in the Schizophrenic Population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19245509 [PubMed - as supplied by publisher] (Source: Journal of the Cardiometabolic Syndrome)
Source: Journal of the Cardiometabolic Syndrome - March 1, 2009 Category: Cardiology Authors: Halpert S, McFarlane SI Tags: J Cardiometab Syndr Source Type: journals

Measures of Coronary Artery Calcification and Association With the Metabolic Syndrome and Diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study suggests that the metabolic syndrome and DM are associated with increased risk of subclinical atherosclerosis. In addition, the presence of the metabolic syndrome or DM with increased FRS has incremental value over the FRS, DM, or the metabolic syndrome alone in predicting significant CAC. PMID: 19245510 [PubMed - as supplied by publisher] (Source: Journal of the Cardiometabolic Syndrome)
Source: Journal of the Cardiometabolic Syndrome - March 1, 2009 Category: Cardiology Authors: Ibebuogu UN, Ahmadi N, Hajsadeghi F, Ramirez J, Flores F, Young E, Gopal A, Wong ND, Budoff MJ Tags: J Cardiometab Syndr Source Type: journals

Waist Circumference, Body Mass Index, and Their Association With Cardiometabolic and Global Risk.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Total body fat and adipose tissue distribution are associated with cardiometabolic risk, yet there are conflicting data as to whether waist circumference (WC) or body mass index (BMI) is a better predictor of cardiovascular risk. To determine whether WC or BMI was more strongly associated with cardiometabolic risk, family members of patients with cardiac disease were studied (N=501; mean age, 48 years; 66% female; 36% nonwhite). Height, weight, WC, BMI, blood pressure, high-density lipoprotein cholesterol, triglycerides, glucose, high-sensitivity C-reactive protein, and lipoprotein-associated phospholipase A(2) were sy...
Source: Journal of the Cardiometabolic Syndrome - March 1, 2009 Category: Cardiology Authors: Christian AH, Mochari H, Mosca LJ Tags: J Cardiometab Syndr Source Type: journals

Drugs Are Not Enough: The Metabolic Syndrome-A Call for Intensive Therapeutic Lifestyle Change.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Whether intensive pharmacologic cardiovascular risk factor management reduces metabolic syndrome (MetS) prevalence is unknown. The authors compared the number of secondary prevention medications and National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III)-defined MetS prevalence in coronary artery disease patients entering cardiac rehabilitation from 1996 to 2001 (period 1, n=516) with those entering from 2002 to 2006 (period 2, n=609). Age, sex, and ethnicity were similar in both periods. From period 1 to period 2, participants took more secondary prevention medications (2.8+/-1.3 vs 3.5+/-1.0, ...
Source: Journal of the Cardiometabolic Syndrome - March 1, 2009 Category: Cardiology Authors: Brown TM, Sanderson BK, Bittner V Tags: J Cardiometab Syndr Source Type: journals

Comparison Between Turkish Cardiovascular Risk Platform and United States National Cholesterol Education Program Adult Treatment Panel III Definitions of the Metabolic Syndrome in Turkish Adults.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Turkish Cardiovascular Risk Platform (TCRP) calls for the diagnosis of the metabolic syndrome (MS) if insulin resistance, impaired fasting glucose, impaired glucose tolerance, or diabetes mellitus and >/=2 other established criteria are present. TCRP defines insulin resistance as a homeostasis model assessment >2.7. The aim of this cross-sectional study was to compare TCRP guidelines with the United States National Cholesterol Education Program Adult Treatment Panel III (NCEP) definition of MS in Turkish adults (N=1690). The age- and sex-adjusted prevalence of MS was 25% with the TCRP and 40% for the NCEP def...
Source: Journal of the Cardiometabolic Syndrome - March 1, 2009 Category: Cardiology Authors: Can AS, Ozbayrakçı S, Palaoğlu KE, Bersot TP Tags: J Cardiometab Syndr Source Type: journals

Coronary Artery Calcification and Inflammation According to Various Metabolic Syndrome Definitions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A number of metabolic syndrome (MS) definitions exist, and one's cardiovascular disease risk may depend on the definition used. The authors compared the association of subclinical atherosclerosis (coronary artery calcification [CAC] score >0] and inflammation (white blood cell [WBC] count greater than or equal to the highest quartile) with 3 definitions of MS (those of the National Cholesterol Education Program Adult Treatment Panel III [NCEP ATP III], the American Heart Association/National Heart, Lung and Blood Institute [AHA/NHLBI], and the International Diabetes Federation [IDF]) in 458 asymptomatic men (mean ag...
Source: Journal of the Cardiometabolic Syndrome - March 1, 2009 Category: Cardiology Authors: Narla V, Santos RD, Campbell CY, Carvalho JA, Nasir K, Budoff MJ, Blumenthal RS, Michos ED Tags: J Cardiometab Syndr Source Type: journals

Insulin Resistance and the Cardiometabolic Syndrome in HIV Infection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Highly active antiretroviral therapy (HAART) has dramatically improved the prognosis of HIV-positive patients. However, long-term adverse effects of this therapy include dyslipidemia, insulin resistance (IR), changes in body fat distribution (lipodystrophy), and cardiometabolic syndrome (CMS). IR in HIV-positive patients does not seem to represent a significant independent risk factor for the development of cardiovascular disease; nevertheless, the association with other metabolic complications (dyslipidemia, fat redistribution) and CMS may increase the risk of type 2 diabetes and cardiovascular disease. The use of nuc...
Source: Journal of the Cardiometabolic Syndrome - March 1, 2009 Category: Cardiology Authors: Bevilacqua M, Dominguez LJ, Barbagallo M Tags: J Cardiometab Syndr Source Type: journals

The Role of Adiponectin in Obesity, Diabetes, and Cardiovascular Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nearly 1 in 4 adults in the United States is obese. The connection between obesity and insulin resistance, type 2 diabetes, and cardiovascular disease is a well researched one. The increasing prevalence of each of these diseases has become a growing concern for the medical community. Adiponectin is a collagen-like plasma protein secreted by adipocytes that has been suggested to play a causal role in the development of insulin resistance and cardiovascular disease. The protein has been found to be decreased in cases of insulin resistance, diabetes, atherosclerosis, and coronary artery disease. Up-regulation of adiponect...
Source: Journal of the Cardiometabolic Syndrome - March 1, 2009 Category: Cardiology Authors: Kawano J, Arora R Tags: J Cardiometab Syndr Source Type: journals

Prevalence and Significance of Cardiometabolic Risk Factors in Children With Type 1 Diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Type 1 diabetes (T1D) is a common disease of childhood with a current prevalence of almost 2 cases per 1000 adolescents, according to the third National Health and Nutrition Examination Survey. Modern insulin treatment has resulted in improved quality of life for children with this chronic disorder. However, T1D continues to carry a long-term burden of increased microvascular and macrovascular complications and mortality risk. Compared to the nondiabetic population, patients with T1D are more likely to have >/=1 cardiovascular risk factor and often at an earlier age. Since the prevalence of cardiovascular risk facto...
Source: Journal of the Cardiometabolic Syndrome - March 1, 2009 Category: Cardiology Authors: Krishnan S, Short KR Tags: J Cardiometab Syndr Source Type: journals

The Role of the Renin-Angiotensin System in the Pathophysiology, Prevention, and Treatment of Renal Impairment in Patients With the Cardiometabolic Syndrome or Its Components.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chronic kidney disease and cardiovascular disease share many risk factors, including hypertension, obesity, and insulin resistance. All of these are components of the cardiometabolic syndrome and are associated with increased risk of morbidity and mortality. One mechanism that links renal injury with the cardiometabolic syndrome is activation of the renin-angiotensin system. Chronic angiotensin II activation promotes development of renal disease through hemodynamic effects and up-regulation of inflammatory cytokines and growth factors. Inhibition of the renin-angiotensin system delays progression of renal disease and i...
Source: Journal of the Cardiometabolic Syndrome - March 1, 2009 Category: Cardiology Authors: Alpert MA, Govindarajan G, Del Rosario ML, Reisin E Tags: J Cardiometab Syndr Source Type: journals

Characterization of the metabolic syndrome by apolipoproteins in the oklahoma cherokee.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Native Americans are susceptible to type 2 diabetes and associated cardiovascular risk that precedes the diabetes. Nondiabetic Cherokee adolescents and young adults were studied for association of apolipoproteins A-I, B, and C-III with the metabolic syndrome, homeostasis model assessment-insulin resistance (HOMA-IR), and body mass index. Apolipoproteins, lipids, selected ratios, and HOMA-IR changed adversely according to the number of metabolic syndrome criteria present (P<.001 for trend). Logistic regression showed heparin-precipitated apolipoprotein C-III, apolipoprotein C-III bound to apolipoprotein B-containing ...
Source: Journal of the Cardiometabolic Syndrome - December 3, 2008 Category: Cardiology Authors: Alaupovic P, Blackett P, Wang W, Lee E Tags: J Cardiometab Syndr Source Type: journals

The effect of pioglitazone on nitric oxide synthase in patients with type 2 diabetes mellitus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to evaluate the effect of pioglitazone on nitric oxide in patients with type 2 diabetes and coronary artery disease. Twenty-seven patients with coronary artery disease and diabetes mellitus who had received coronary stenting were eligible for the study. They were assigned to the no insulin resistance (NIR) group, the insulin resistance (IR) group, and the pioglitazone group (30 mg once a day). Endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-alpha), interleukin-6, leptin, and adiponectin were measured. In the pioglitazone group,...
Source: Journal of the Cardiometabolic Syndrome - December 3, 2008 Category: Cardiology Authors: Nishio K, Shigemitsu M, Kodama Y, Itoh S, Konno N, Satoh R, Katagiri T, Kobayashi Y Tags: J Cardiometab Syndr Source Type: journals

Metabolic syndrome resolution in children and adolescents after 10 weeks of weight loss.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Without aggressive intervention, childhood obesity and the metabolic syndrome may result in lifelong physical consequences. Interventions that emphasize healthy eating and regular exercise are crucial to stop this epidemic and its ramifications. This paper discusses the incidence of the metabolic syndrome and cardiovascular risk factors before and after a weight loss program. A retrospective review was conducted in 135 children and adolescents (aged 6 to 19) who completed a 10-week medically supervised weight loss program. Outcome measures included mean change in each component of the metabolic syndrome, total choleste...
Source: Journal of the Cardiometabolic Syndrome - December 3, 2008 Category: Cardiology Authors: Coppen AM, Risser JA, Vash PD Tags: J Cardiometab Syndr Source Type: journals

The insulin gradient phenomenon: a manifestation of the effects of body weight on blood pressure and insulin resistance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The relationship between hyperinsulinemia and hypertension is frequently observed in overweight patients; however, population studies have not confirmed an independent association. A population study was conducted to assess whether differences in body mass index and levels of insulinemia modify cardiovascular hemodynamics and arterial pressure. In all, 322 healthy adults underwent a medical evaluation including insulin sensitivity and cardiac performance assessment with echocardiography. A direct relationship between body mass index and blood pressure (r=0.36; P<.01) was shown along with increments in fasting insuli...
Source: Journal of the Cardiometabolic Syndrome - December 3, 2008 Category: Cardiology Authors: Aristizabal D, Gallo J, Fernández R, Restrepo MA, Zapata N, Correa M Tags: J Cardiometab Syndr Source Type: journals

The metabolic syndrome among patients undergoing cardiac catheterization in jordan.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was conducted to determine the prevalence of the metabolic syndrome (MeS) and its associated factors among patients undergoing cardiac catheterization in north Jordan. A cross-sectional study was conducted among patients who underwent cardiac catheterization at King Abdullah University Hospital in north Jordan. Data from 360 patients were collected through personal interview, medical records, and anthropometric measurements. MeS was defined using National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and International Diabetes Federation (IDF) criteria. The prevalence of MeS among patien...
Source: Journal of the Cardiometabolic Syndrome - December 3, 2008 Category: Cardiology Authors: Khader Y, Khatatbeh M, El-Salem K, Amarin Z, Bateiha A Tags: J Cardiometab Syndr Source Type: journals

Attenuation of endocrine-exocrine pancreatic communication in type 2 diabetes: pancreatic extracellular matrix ultrastructural abnormalities.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ultrastructural observations reveal a continuous interstitial matrix connection between the endocrine and exocrine pancreas, which is lost due to fibrosis in rodent models and humans with type 2 diabetes mellitus (T2DM). Widening of the islet-exocrine interface appears to result in loss of desmosomes and adherens junctions between islet and acinar cells and is associated with hypercellularity consisting of pericytes and inflammatory cells in T2DM pancreatic tissue. Organized fibrillar collagen was closely associated with pericytes, which are known to differentiate into myofibroblasts-pancreatic stellate cells. Of impor...
Source: Journal of the Cardiometabolic Syndrome - December 3, 2008 Category: Cardiology Authors: Hayden MR, Patel K, Habibi J, Gupta D, Tekwani SS, Whaley-Connell A, Sowers JR Tags: J Cardiometab Syndr Source Type: journals

Omega-3 Fatty acids and the cardiometabolic syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this paper is to evaluate the potential health benefits of fish consumption and/or fish oil supplements in reducing cardiometabolic syndrome risk factors. The consumption of fish or fish oil containing omega-3 polyunsaturated fatty acids reduces the risk of coronary heart disease, decreases triglyceride, blood pressure, and inflammatory markers, improves endothelial function, prevents certain cardiac arrhythmias, reduces platelet aggregation (including reactivity and adhesion), reduces vasoconstriction, enhances fibrinolysis, reduces fibrin formation, and decreases the risk of microalbuminuria and sudden c...
Source: Journal of the Cardiometabolic Syndrome - December 3, 2008 Category: Cardiology Authors: Juturu V Tags: J Cardiometab Syndr Source Type: journals

Surgical treatment of the cardiometabolic syndrome and obesity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Prevalence of overweight and obesity has reached a pandemic proportion worldwide and is increasingly contributing to premature morbidity and mortality. Lifestyle changes including behavioral modification, exercise, different dietary plans, and medications have very poor outcome on long-term weight loss. Bariatric surgery has shown to be very effective for morbidly obese patients. Surgery in these patients not only decreases their body weight but also may improve comorbid conditions associated with obesity. These patients on average lose 61% of excess body weight depending on the procedure performed. Diabetes, hyperlipi...
Source: Journal of the Cardiometabolic Syndrome - December 3, 2008 Category: Cardiology Authors: Khan KA, Sowers JR Tags: J Cardiometab Syndr Source Type: journals

Strain imaging using speckle tracking in the cardiometabolic syndrome: method and utility.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19040596 [PubMed - in process] (Source: Journal of the Cardiometabolic Syndrome)
Source: Journal of the Cardiometabolic Syndrome - December 3, 2008 Category: Cardiology Authors: Vrain JS, Bilhorn K, Kurup S, Peterson LR Tags: J Cardiometab Syndr Source Type: journals

Pancreatic Renin-Angiotensin-aldosterone system in the cardiometabolic syndrome and type 2 diabetes mellitus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18983326 [PubMed - in process] (Source: Journal of the Cardiometabolic Syndrome)
Source: Journal of the Cardiometabolic Syndrome - November 7, 2008 Category: Cardiology Authors: Hayden MR, Sowers JR Tags: J Cardiometab Syndr Source Type: journals

A 5-year follow-up study of 3 polymorphisms in the human glucocorticoid receptor gene in relation to obesity, hypertension, and diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the current study was to examine the prospective association of 3 polymorphisms-a Tth111I restriction fragment in the promoter region, a BclI polymorphism in intron 2, and an A/G polymorphism in exon 2-of the GRL gene on estimates of obesity, hypertension, and diabetes in 163 unrelated Swedish men born in 1944. These data showed a significant increase in body weight, body mass index, abdominal obesity, fasting glucose, insulin, and homeostasis model assessment over the 5-year follow-up among homozygotes for the rare BclI allele. In contrast, no significant associations with the Tth111I or A/G polymorphism ...
Source: Journal of the Cardiometabolic Syndrome - November 7, 2008 Category: Cardiology Authors: Rosmond R, Holm G Tags: J Cardiometab Syndr Source Type: journals

Impact of cardiac rehabilitation on coronary risk factors, inflammation, and the metabolic syndrome in obese coronary patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Obesity is a coronary heart disease (CHD) risk factor and is prevalent in patients with CHD. The authors reviewed data in 235 consecutive patients before and after formal cardiac rehabilitation and exercise training (CRET) programs and analyzed data in 72 lean patients (body mass index [BMI] <25 kg/m(2)) vs 73 obese patients (BMI>/=30 kg/m(2)). At baseline, obese patients were significantly younger (P<.0001); had higher percentage of body fat (P<.0001) and more dyslipidemia, including higher triglycerides (TG; P<.01), lower high-density lipoprotein (HDL) cholesterol (P<.0001), and higher TG/HDL ratio ...
Source: Journal of the Cardiometabolic Syndrome - November 7, 2008 Category: Cardiology Authors: Lavie CJ, Morshedi-Meibodi A, Milani RV Tags: J Cardiometab Syndr Source Type: journals

Chronic low-dose lipid infusion in healthy patients induces markers of endothelial activation independent of its metabolic effects.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Elevated plasma triglyceride/free fatty acid (FFA) levels and insulin resistance may promote atherosclerosis through endothelial activation (ie, increased expression of intercellular adhesion molecule 1 [ICAM-1]/vascular adhesion molecule 1 [VCAM-1], and endothelin-1 [ET-1]) in patients with the metabolic syndrome, but this has never been directly tested. The authors measured endothelial activation and insulin sensitivity (euglycemic insulin clamp with [3-(3)H]-glucose) after a 4-day low-dose lipid infusion that elevated plasma FFA to levels observed in the metabolic syndrome in 20 lean, non-diabetic insulin-resistant ...
Source: Journal of the Cardiometabolic Syndrome - November 7, 2008 Category: Cardiology Authors: Kashyap SR, Belfort R, Cersosimo E, Lee S, Cusi K Tags: J Cardiometab Syndr Source Type: journals

Obesity: a central risk and cardiovascular target of the cardiometabolic syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18983330 [PubMed - in process] (Source: Journal of the Cardiometabolic Syndrome)
Source: Journal of the Cardiometabolic Syndrome - November 7, 2008 Category: Cardiology Authors: Frohlich ED Tags: J Cardiometab Syndr Source Type: journals

Obesity and dysrhythmias.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the histopathophysiologic changes that occur in cardiac structure and function in response to obesity, explores the relationship between obesity and arrhythmias such as atrial fibrillation and sudden cardiac death, and analyzes electrocardiographic changes in an obese patient. PMID: 18983331 [PubMed - in process] (Source: Journal of the Cardiometabolic Syndrome)
Source: Journal of the Cardiometabolic Syndrome - November 7, 2008 Category: Cardiology Authors: Anand RG, Peters RW, Donahue TP Tags: J Cardiometab Syndr Source Type: journals

Impact of obesity on the risk of heart failure and its prognosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Obesity is becoming a global epidemic in both children and adults, and it is associated with numerous comorbidities such as coronary heart disease, stroke/cerebrovascular disease, type 2 diabetes, hypertension, certain cancers, and sleep-disordered breathing. Over the past 2 decades, the incidence of and mortality from coronary heart disease and cardiovascular diseases has been continuously declining. In contrast, the incidence of and mortality from heart failure (HF) have been increasing, with HF diagnosed in approximately 5 million Americans and 550,000 new cases diagnosed each year and a death rate looming at 300,00...
Source: Journal of the Cardiometabolic Syndrome - November 7, 2008 Category: Cardiology Authors: Artham SM, Lavie CJ, Patel HM, Ventura HO Tags: J Cardiometab Syndr Source Type: journals

Impact of obesity on the pathogenesis and prognosis of coronary heart disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Obesity has a significant adverse effect on coronary heart disease (CHD) risk factors, including hypertension, dyslipidemia, and the metabolic syndrome/diabetes. Obesity is an independent risk factor for CHD events; however, obese patients with CHD generally have a more favorable prognosis, with the worst prognosis associated with either underweight or morbidly obese patients. In this manuscript, the authors review the impact of obesity on overall CHD risk as well as the prognosis of obese patients with established CHD. PMID: 18983333 [PubMed - in process] (Source: Journal of the Cardiometabolic Syndrome)
Source: Journal of the Cardiometabolic Syndrome - November 7, 2008 Category: Cardiology Authors: Todd Miller M, Lavie CJ, White CJ Tags: J Cardiometab Syndr Source Type: journals

Obesity, hypertension, and the heart.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Controversy exists regarding the amount of risk caused by obesity, but there is general consensus that it is associated with many serious disorders, mostly cardiovascular and neoplastic. Obesity is clearly associated with hypertension, ventricular remodeling with subsequent congestive heart failure, sleep-disordered breathing, and sudden death. The physiologic alterations associated with establishing and perpetuating the obese state are complex but are becoming clear. In discussing the cardiovascular consequences of obesity, the implications and mechanism of the associated hypertension need to be understood. There is g...
Source: Journal of the Cardiometabolic Syndrome - November 7, 2008 Category: Cardiology Authors: Good D, Morse SA, Ventura HO, Reisin E Tags: J Cardiometab Syndr Source Type: journals

Costs of and reasons for obesity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this literature review was to identify and describe the cost of obesity, the contributing factors, and the use of taxation as a possible method of control of this epidemic in a Canadian setting. A review of the current literature found on the PubMed/MEDLINE services of the National Institutes of Health as well as an analysis of Web content was conducted. The PubMed/MEDLINE search identified 677 articles pertaining to Canada and obesity, 323 articles relating to price policy, 26 articles concerning obesity and taxes, and 29 articles about obesity, Canada, and cost (1964-March 2007). The cost of obesity in...
Source: Journal of the Cardiometabolic Syndrome - November 7, 2008 Category: Cardiology Authors: Witkos M, Uttaburanont M, Lang CD, Arora R Tags: J Cardiometab Syndr Source Type: journals

Challenges to the diagnosis, evaluation, treatment, and management of clustered cardiometabolic risk factors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A panel was convened on February 18, 2008, to discuss the challenges to the diagnosis, evaluation, treatment, and management of clustered cardiometabolic risk factors. Peter W.F. Wilson, MD of Emory University School of Medicine, Atlanta, GA, moderated the panel. Henry R. Black, MD, New York University School of Medicine, New York, NY, Anthony N. Fabricatore, PhD, University of Pennsylvania, Philadelphia, PA, and Ira J. Goldberg, MD, Columbia University, New York, NY, participated in the discussion. This expert panel discussion was supported by and each author received an honorarium from Pfizer Inc for time and effort ...
Source: Journal of the Cardiometabolic Syndrome - November 7, 2008 Category: Cardiology Authors: Wilson PW, Black HR, Fabricatore AN, Goldberg IJ Tags: J Cardiometab Syndr Source Type: journals

Insulin resistance and endothelin: another pathway for renal injury in patients with the cardiometabolic syndrome?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article discusses the existing data on the interactions between insulin resistance, hyperinsulinemia, and endothelin and how these can lead to renal damage in patients with the cardiometabolic syndrome. PMID: 18983337 [PubMed - in process] (Source: Journal of the Cardiometabolic Syndrome)
Source: Journal of the Cardiometabolic Syndrome - November 7, 2008 Category: Cardiology Authors: Sarafidis PA, Lasaridis AN Tags: J Cardiometab Syndr Source Type: journals

The controversy regarding contrast echocardiography and how it affects patients with the cardiometabolic syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18983338 [PubMed - in process] (Source: Journal of the Cardiometabolic Syndrome)
Source: Journal of the Cardiometabolic Syndrome - November 7, 2008 Category: Cardiology Authors: Wagner DL, Pérez JE, Peterson LR, Rasalingam R Tags: J Cardiometab Syndr Source Type: journals

Bayesian meta-analysis of tissue angiotensin-converting enzyme inhibitors for reduction of adverse cardiovascular events in patients with diabetes mellitus and preserved left ventricular function.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The role of angiotensin-converting enzyme (ACE) inhibitors in diabetic patients with preserved ventricular function is uncertain. Tissue ACE inhibitors have been defined by increased lipophilicity and structural characteristics that result in greater tissue-specific ACE binding when compared with plasma ACE inhibitors. A Bayesian meta-analysis of randomized trials was conducted to evaluate tissue ACE inhibitors in prevention of cardiovascular disease among patients with diabetes mellitus and preserved left ventricular function. Four trials were selected that evaluated 2 different ACE inhibitors and included 10,328 pati...
Source: Journal of the Cardiometabolic Syndrome - July 3, 2008 Category: Cardiology Authors: Lang CD, Arora RR, Saha SA, Molnar J Tags: J Cardiometab Syndr Source Type: journals

The endocannabinoid system: a promising novel mechanistic pathway in the cardiometabolic syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The endocannabinoid system (ECS) is a neuroendocrine system that modulates several cardiometabolic processes. An overactive ECS is implicated as a significant contributor to the cardiometabolic syndrome and obesity, in addition to a large number of other physiologic processes. Endocannabinoid receptors have been detected centrally and peripherally, regulating appetite, food intake, metabolism, and storage. ECS blockade is thought to be a promising new pharmacologic modality of improving the unfavorable metabolic risk profile in patients with the cardiometabolic syndrome and obesity. PMID: 18326971 [PubMed - indexed...
Source: Journal of the Cardiometabolic Syndrome - July 3, 2008 Category: Cardiology Authors: Al-Jaghbeer E, Khraisat A, Singh SP Tags: J Cardiometab Syndr Source Type: journals

Reversal of diuretic-associated impaired glucose tolerance and new-onset diabetes: results of the STAR-LET study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Reversal of new-onset diabetes secondary to thiazide diuretic use remains questionable. STAR-LET was a 6-month extension of the Study of Trandolapril/Verapamil SR and Insulin Resistance (STAR), which assessed the effects of a fixed-dose renin-angiotensin system inhibitor (RASI)/hydrochlorothiazide (HCTZ) combination on changes in 2-hour oral glucose tolerance test (OGTT) results. STAR-LET explored whether the glycemic impact of HCTZ could be reversed by conversion to a RASI/verapamil combination. The primary outcome was change in 2-hour OGTT results. Fifty-one percent of the STAR patients were enrolled in STAR-LET. The...
Source: Journal of the Cardiometabolic Syndrome - July 3, 2008 Category: Cardiology Authors: Bakris G, Molitch M, Zhou Q, Sarafidis P, Champion A, Bacher P, Sowers JR Tags: J Cardiometab Syndr Source Type: journals

The cardiometabolic syndrome and liver disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18326973 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome)
Source: Journal of the Cardiometabolic Syndrome - July 3, 2008 Category: Cardiology Authors: Sowers JR Tags: J Cardiometab Syndr Source Type: journals

Ethnic gap in coronary artery disease: comparison of the extent, severity, and risk factors in Arab and Jewish middle-aged women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors examined risk factors and extent of coronary artery disease (CAD) among Jewish and Arab women in Jerusalem, where Arab women were found to have worse outcome. All angiographically confirmed cases of CAD among women aged 45 to 65 years who were hospitalized during 1990 to 1995 consisted of 40 Arab and 179 Jewish patients. Arab women had more atypical clinical presentations (P<.0001) and more extensive CAD (P=.0016) despite younger age (53+/-3 vs 55+/-5 years; P<.0003) and lesser smoking (P<.0006). The Arab women, however, were more likely to be obese (80% vs 46%; P=.0002), be physically inactive (10...
Source: Journal of the Cardiometabolic Syndrome - July 3, 2008 Category: Cardiology Authors: Salameh S, Hochner-Celnikier D, Chajek-Shaul T, Manor O, Bursztyn M Tags: J Cardiometab Syndr Source Type: journals

Calciphylaxis: a severe complication of the cardiometabolic syndrome in patients receiving hemodialysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18326975 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome)
Source: Journal of the Cardiometabolic Syndrome - July 3, 2008 Category: Cardiology Authors: Verdalles U, Cueva Pde L, Verde E, Vinuesa SG, Goicoechea M, Mosse A, Lopez-Gomez JM, Luño J Tags: J Cardiometab Syndr Source Type: journals

The apolipoprotein b/apolipoprotein AI ratio in the metabolic syndrome-should we start using it?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18326976 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome)
Source: Journal of the Cardiometabolic Syndrome - July 3, 2008 Category: Cardiology Authors: Sierra-Johnson J, Romero-Corral A, Somers VK, Lopez-Jimenez F Tags: J Cardiometab Syndr Source Type: journals

Calciphylaxis and the cardiometabolic syndrome: the emerging role of sodium thiosulfate as a novel treatment option.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18326977 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome)
Source: Journal of the Cardiometabolic Syndrome - July 3, 2008 Category: Cardiology Authors: Hayden MR Tags: J Cardiometab Syndr Source Type: journals

Vascular compliance in the cardiometabolic syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Elevated systolic blood pressure and increased pulse pressure are important predictors of vascular stiffening (compliance), left ventricular hypertrophy, coronary heart disease, heart failure, stroke, vascular dementia, and chronic kidney disease. Advances in noninvasive methods that measure arterial stiffness have led to increased understanding of the mechanisms underlying vascular dysfunction and the development of associated risk factors. The ability to detect and monitor changes in the physical properties of arteries has the potential to allow early interventions that may prevent disease or attenuate its progressio...
Source: Journal of the Cardiometabolic Syndrome - July 3, 2008 Category: Cardiology Authors: Ganne S, Winer N Tags: J Cardiometab Syndr Source Type: journals

The metabolic syndrome adds incremental value to the Framingham risk score in identifying asymptomatic individuals with higher degrees of inflammation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent studies have shown that elevated white blood cell (WBC) counts independently predict adverse cardiovascular disease (CVD) outcomes. The metabolic syndrome (MS) is known to be associated with a higher degree of inflammation and increased CVD risk. It is unclear, however, whether MS provides incremental information to the Framingham risk score (FRS). The authors studied 458 asymptomatic men, of whom 112 had MS. WBC count was used as a marker of inflammation. The odds ratio (OR) for presence of WBCs in the highest quartile vs the lower 3 quartiles was 2.2; 95% confidence interval (CI), 1.39-3.40 for MS. After furth...
Source: Journal of the Cardiometabolic Syndrome - July 3, 2008 Category: Cardiology Authors: Campbell CY, Nasir K, Carvalho JA, Blumenthal RS, Santos RD Tags: J Cardiometab Syndr Source Type: journals

Effects of angiotensin-converting enzyme inhibitor therapy on levels of inflammatory markers in response to exercise-induced stress: studies in the metabolic syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors sought to determine whether the angiotensin-converting enzyme (ACE) inhibitor perindopril has beneficial effects on vascular markers of inflammation in patients with the metabolic syndrome when exposed to exercise-induced stress. Thirty patients with the metabolic syndrome were randomized to perindopril (4 mg/d) or placebo in a double-blind fashion for 4 weeks. Prior to treatment, the patients underwent an exercise treadmill study to a level of 8 metabolic equivalents. Circulating monocyte CD11b expression, levels of soluble interleukin 6 (sIL-6), and levels of vascular cell adhesion molecule-1 (VCAM-1) wer...
Source: Journal of the Cardiometabolic Syndrome - July 3, 2008 Category: Cardiology Authors: Vaccari CS, Rahman ST, Khan QA, Cheema FA, Khan BV Tags: J Cardiometab Syndr Source Type: journals

High-dose atorvastatin after stroke or transient ischemic attack: The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18326981 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome)
Source: Journal of the Cardiometabolic Syndrome - July 3, 2008 Category: Cardiology Authors: , Karam JG, Loney-Hutchinson L, McFarlane SI Tags: J Cardiometab Syndr Source Type: journals

Homocysteine competes for the peroxisome proliferator-activated receptor nuclear receptors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18326982 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome)
Source: Journal of the Cardiometabolic Syndrome - July 3, 2008 Category: Cardiology Authors: Hayden MR Tags: J Cardiometab Syndr Source Type: journals

Environmental stress, erythrocyte dysfunctions, inflammation, and the metabolic syndrome: adaptations to CO2 increases?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the Western world, the prevalence of the metabolic syndrome is increasing exponentially. Chronic subacute inflammation characterizes the syndrome, suggesting that inflammation might be a common denominator that links obesity to its pathologic sequelae. Potential mechanisms for the activation of inflammation include current air pollution inhalation and/or excess food intake. Both of these environmental factors have, in fact, been shown to promote oxidation followed by the release of proinflammatory cytokines. Potential sources of systemic inflammation include oxidized erythrocytes. Increased exogenous or endogenous C...
Source: Journal of the Cardiometabolic Syndrome - July 3, 2008 Category: Cardiology Authors: Zappulla D Tags: J Cardiometab Syndr Source Type: journals

Noninvasive diagnosis of subclinical atherosclerosis in cardiometabolic syndrome: a call to action.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18326984 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome)
Source: Journal of the Cardiometabolic Syndrome - July 3, 2008 Category: Cardiology Authors: Kotliar C, Forcada P, Ferdinand KC Tags: J Cardiometab Syndr Source Type: journals

Cardiometabolic disease in the human immunodeficiency virus: the tip of the iceberg?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18453805 [PubMed - in process] (Source: Journal of the Cardiometabolic Syndrome)
Source: Journal of the Cardiometabolic Syndrome - July 3, 2008 Category: Cardiology Authors: Todd Cade W, Yarasheski KE Tags: J Cardiometab Syndr Source Type: journals