Journal of the International Association of Physicians in AIDS Care (JIAPAC)This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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HIV-Infected Thais Need Help to Adjust to a Normal Life in SocietyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - September 16, 2009 Category: Infectious Diseases Authors: Hultqvist, E., Martensson, T., Samnang, V., Andersson, R. Tags: Articles Source Type: journals

A Retrospective Analysis of AIDS-Associated Kaposi's Sarcoma in Patients With Undetectable HIV Viral Loads and CD4 Counts Greater Than 300 cells/mm3Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In the highly active antiretroviral (HAART) era, a substantial proportion of patients with KS had undetectable HIV VLs and CD4 counts greater than the level typically associated with opportunistic diseases. They required systemic therapy to control their KS but were significantly less likely to die and demonstrated a trend toward better 15-year survival than patients having KS with lesser CD4 counts and detectable HIV VLs.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - September 16, 2009 Category: Infectious Diseases Authors: Mani, D., Neil, N., Israel, R., Aboulafia, D. M. Tags: Articles Source Type: journals

Human Papillomavirus in Women With and Without HIV-1 Infection Attending an STI Clinic in Vitoria, BrazilEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We conducted a cross-sectional study in Vitória, Brazil, to assess the prevalence of human papillomavirus (HPV) infection in HIV-positive and HIV-negative women attending a sexually transmitted infection (STI)/AIDS clinic. We also investigated the presence of HPV genotypes and assessed covariates for HIV infection. Enrolled patients received a gynecological evaluation, and cervical scrape samples were collected for cytological analysis and HPV-DNA polymerase chain reaction (PCR). A blood sample was obtained to determine HIV status. HPV infection and squamous intraepithelial lesions were studied in 284 women, 112 (39...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - September 16, 2009 Category: Infectious Diseases Authors: Coelho Lima, B. M., Golub, J. E., Tonani Mattos, A., Bueno de Freitas, L., Cruz Spano, L., Espinosa Miranda, A. Tags: Articles Source Type: journals

When ''No'' Means ''Yes'': The Gender Implications of HIV Programming in a Zimbabwean UniversityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our study suggests that HIV prevention efforts targeted at university students need to incorporate a discussion of broader cultural beliefs, particularly those pertaining to gender role myths, if they are to be effective.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - September 16, 2009 Category: Infectious Diseases Authors: Masvawure, T. B., Terry, P. E., Adlis, S., Mhloyi, M. Tags: Articles Source Type: journals

Comparison of 3-Drug Versus 4-Drug and PI Versus Non-PI Combinations as Initial HAART: Experience From 1998 to 2007Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although established in controlled studies that there is no advantage to 4-drug highly active antiretroviral therapy (HAART) or regimens with or without protease inhibitors (PIs), we questioned this finding in a clinical setting (ie, no inclusion criteria). Ours is a single clinic retrospective study including all participants >18 years of age during their first year of HAART. A total of 190 participants were reviewed, with 168 (88%) attaining a viral load <400 copies/mL at the end of a year of HAART; 144 of 164 (88%) succeeded with 3 drugs and 24 of 26 (92%) with 4 drugs (P = .51). In all, 59 of 71 (83%) succeeded u...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - September 16, 2009 Category: Infectious Diseases Authors: Jhaveri, M. A., Browning, S. R., Bush, H., Thornton, A., Greenberg, R. N. Tags: Articles Source Type: journals

Observational Study to Evaluate Clinical Outcomes After First-Line Efavirenz-or Lopinavir-Ritonavir-Based HAART in Treatment-Naive PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In a routine clinical care setting, initial HAART containing LPV/r seems to present an effectiveness, tolerability, and toxicity similar to the one containing EFV.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - September 16, 2009 Category: Infectious Diseases Authors: Perez-Elias, M. J., Moreno, A., Casado, J. L., Dronda, F., Antela, A., Lopez, D., Quereda, C., Navas, E., Hermida, J. M., Del Sol, E., Moreno, S. Tags: Articles Source Type: journals

First HAART in HIV-Infected Patients With High Viral Load: Value of HIV RNA Levels at 12 Weeks to Predict Virologic OutcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study is to identify the role of incomplete suppression during the first months of highly active antiretroviral treatment (HAART) to predict virologic failure in patients with high levels of HIV replication. In a retrospective, longitudinal, and multicenter study, response to HAART was assessed in treatment-naive adults with HIV RNA >100 000 copies/mL, and factors predicting failure were analyzed through regression analyses. A total of 118 patients were included. Virologic failure occurred more often in patients with >500 copies/mL at week 12 (Cox regression: Exp (B) 3.22; P = .02). HIV RNA >500 co...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - September 16, 2009 Category: Infectious Diseases Authors: Townsend, D., Troya, J., Maida, I., Perez-Saleme, L., Satta, G., Wilkin, A., Barreiro, P., Pegram, P. S., Soriano, V., Mura, M. S., Nunez, M. Tags: Articles Source Type: journals

Adverse Drug Reactions to Nonnucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Regimen: A 24-Week Prospective StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: As the developing world increasingly uses generic ART, the clinician must be constantly vigilant for treatment-related adverse events.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - September 16, 2009 Category: Infectious Diseases Authors: Jena, A., Sachdeva, R. K., Sharma, A., Wanchu, A. Tags: Articles Source Type: journals

Primary HIV-1 Drug Resistance and Polymorphic Patterns Among Injecting Drug Users (IDUs) in Chennai, Southern IndiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The presence of drug resistance mutations, though minimal, is alarming as it could spread easily between IDUs and from them to their sexual partners. The genetic variation is of importance in vaccine design.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - September 16, 2009 Category: Infectious Diseases Authors: Iqbal, H. S., Solomon, S. S., Madhavan, V., Solomon, S., Balakrishnan, P. Tags: Articles Source Type: journals

Immune Reconstitution Visceral Leishmaniasis Presented as Hemophagocytic Syndrome in a Patient With AIDS From a Nonendemic Area: A Case ReportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Visceral Leishmaniasis (VL) is endemic in the Ganges and Brahmaputra plains of India. Leishmaniasis/HIV coinfection is on the rise in India and may pose a real diagnostic and therapeutic challenge. HIV-related immunosuppression increases the risk of reactivating leishmaniasis by 100 to 1000 times and it also increases the risk of drug resistant leishmaniasis. Immune reconstitution VL is not very well reported in literature. Hemophagocytosis is known to occur with various infectious agents like viruses, bacteria, and parasites, but is rare to occur with leishmaniasis. Here the authors describe a case of VL presenting as imm...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - August 31, 2009 Category: Infectious Diseases Authors: Patel, K. K., Patel, A. K., Sarda, P., Shah, B. A., Ranjan, R. Tags: Article Source Type: journals

Risk-Taking Behaviors Among Vertically HIV-Infected Adolescents in Northern ThailandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Rates of substance use and sexual activity were low in this population. STI knowledge was poor and diagnosis self-disclosure was infrequent. Improved sexual education and self-disclosure skills are needed among vertically HIV-infected adolescents in Thailand.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - August 31, 2009 Category: Infectious Diseases Authors: Lee, B., Oberdorfer, P. Tags: Article Source Type: journals

Cold Agglutinins in HIV-Seropositive Participants and Diagnosis of Respiratory Disease Due to Mycoplasma pneumoniaeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. Our report suggests a basis for the existence of CAs in HIV-positive cases. Definitive diagnosis may be done only when CA detection is used in conjunction with a specific test.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - August 31, 2009 Category: Infectious Diseases Authors: Esaki Muthu Shankar, , Vignesh, R., Balakrishnan, P., Velu, V., Ponmalar, E., Murugavel, K. G., Saravanan, S., Nandagopal, P., Hayath, K., Solomon, S., Vengatesan, A., Usha Anand Rao, Tags: Article Source Type: journals

Strongyloides stercoralis Hyperinfection in a Patient With AIDSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of S stercoralis hyperinfection in an HIV-infected patient, which resulted in death.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - August 31, 2009 Category: Infectious Diseases Authors: Bava, A. J., Troncoso, A. R. Tags: Article Source Type: journals

Radiation Therapy for HIV-Associated Diffuse Large Cell Non-Hodgkin LymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. After chemotherapy, RT in combination with HAART is highly active, and RT should be encouraged especially after suboptimal responses to induction treatment.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - August 31, 2009 Category: Infectious Diseases Authors: Rothschild, S., Dolder, M., Seifert, B., Lutolf, U. M., Ciernik, I. F. Tags: Article Source Type: journals

Clinicians' Knowledge of 2007 Food and Drug Administration Recommendation to Discontinue Nelfinavir Use During PregnancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In 2007, the US Food and Drug Administration (FDA) and Pfizer Inc recommended immediate discontinuation of nelfinavir (NFV) during pregnancy due to contamination with a potential teratogen. A few weeks after the announcement, we surveyed antenatal HIV care providers to determine how widely the warning was disseminated. Overall, 69 of 121 (57.0%) providers knew to discontinue NFV. Callers with more than 50 HIV-infected patients were 2.54 times as likely to be aware as callers with 1-3 HIV-infected patients (P < .01). Only 12 (33.3%) obstetricians were aware, compared to 21 (80.8%) infectious diseases specialists (P < ...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - August 31, 2009 Category: Infectious Diseases Authors: Fogler, J., Weber, S., Mahoney, M. R., Goldschmidt, R. H. Tags: Article Source Type: journals

Obstacles and Proposed Solutions to Effective Antiretroviral Therapy in Resource-Limited SettingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
More than 3 million people were receiving antiretroviral therapy (ART) at the end of 2007, but this number represents only 31% of people clinically eligible for ART in resource-limited settings. The primary objective of this study is to summarize the key obstacles that impede the goal of universal access prevention, care, and treatment. We performed a systematic literature search to review studies that reported barriers to diagnosis and access to treatment of HIV/AIDS in resource-limited countries. Persons living with HIV/ AIDS commonly face economic, sociocultural, and behavioral obstacles to access treatment and care for...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - August 31, 2009 Category: Infectious Diseases Authors: Bartlett, J. A., Hornberger, J., Shewade, A., Bhor, M., Rajagopalan, R. Tags: Article Source Type: journals

Cofactors for Low Serum Albumin Levels Among HIV-Infected Individuals in Southern IndiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. CD4 count and lower were the major cofactors for low serum albumin among HIV-infected individuals. Therefore, serum albumin would be a useful biochemical test for HIV disease in resource-limited settings.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - May 29, 2009 Category: Infectious Diseases Authors: Sundaram, M., Srinivas, C.N., Shankar, E.M., Balakrishnan, P., Solomon, S., Kumarasamy, N. Tags: Article Source Type: journals

Daily Trimethoprim-Sulfamethoxazole Prophylaxis Rapidly Induces Corresponding Resistance Among Intestinal Escherichia coli of HIV-Infected Adults in KenyaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Daily prophylaxis with TMP-SMZ induced in vivo resistance to the drug after 2 weeks. Empiric therapy for diarrhea with agents other than TMP-SMZ should be considered for HIV-infected persons receiving daily TMP-SMZ prophylaxis.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - May 29, 2009 Category: Infectious Diseases Authors: Chiller, T.M., Polyak, C.S., Brooks, J.T., Williamson, J., Ochieng, B., Shi, Y.P., Ouma, P., Greene, C., Hamel, M., Vulule, J., Bopp, C., Slutsker, L., Mintz, E. Tags: Article Source Type: journals

Trends in HIV/TB Coinfection in Trinidad and Tobago for the Period 1998-2007Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. The incidence of TB and HIV/TB coinfection rates continues to be major challenges in the developing world. Demographic, socioeconomic trends as well as risk factors remain unchanged. Increased HIV screening and HAART coverage offers hope for the future.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - May 29, 2009 Category: Infectious Diseases Authors: Mungrue, K., Beharry, A., Kalloo, J., Mahabir, S., Maraj, T., Ramoutar, R., Ramsaroop, K., Solomon, V. Tags: Article Source Type: journals

Community-Associated Methicillin-Resistant Staphylococcus aureus Skin and Soft-Tissue Infection in HIV-Infected PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. A majority of our patients with CA-MRSA SSTI did not have immunological/virological markers consistent with severe HIV/AIDS disease at time of presentation.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - May 29, 2009 Category: Infectious Diseases Authors: Trinh, T. T., Short, W. R., Mermel, L. A. Tags: Article Source Type: journals

Dried Blood Spots Versus Plasma for the Quantification of HIV-1 RNA Using the Manual (PCR-ELISA) Amplicor Monitor HIV-1 Version 1.5 Assay in Yaounde, CameroonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Even when using an entirely manual HIV-quantification assay, DBS may provide a reliable, cost-effective method for sample collection and storage for HIV-1 RNA quantification in resource-limited settings.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - May 29, 2009 Category: Infectious Diseases Authors: Ikomey, G.M., Atashili, J., Okomo-Assoumou, M.C., Mesembe, M., Ndumbe, P.M. Tags: Article Source Type: journals

Enteric Bacterial Pathogens in HIV-Infected Children With Acute Diarrhea in Mulago Referral and Teaching Hospital, Kampala, UgandaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Escherichia coli, Salmonella, and Shigella species significantly cause acute diarrhea in HIV-infected and -uninfected children and they are highly resistant to cotrimoxazole.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - May 29, 2009 Category: Infectious Diseases Authors: Musiime, V., Kalyesubula, I., Kaddu-Mulindwa, D., Byarugaba, J. Tags: Article Source Type: journals

Seven-Year Follow-Up on Lopinavir/ Ritonavir MonotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Previous studies of lopinavir/ritonavir (LPV/r) monotherapy have shown that over 70% of patients achieved HIV RNA levels <500 copies/mL over a follow-up period of 48 to 96 weeks, but the long-term durability is undetermined. Herein, the authors report 2 patients that started LPV/r monotherapy after virologic failure on an NNRTIbased regimen and have been successfully treated for greater than 7 years. Both patients demonstrated long-term control of viral replication over the course of treatment, although the first patient had 3 viral load blips and the second had 1 blip under 400 copies/mL. Both patients had increases in...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - May 29, 2009 Category: Infectious Diseases Authors: Pierone, G., Mieras, J., Martin, A., Urban, T. Tags: Article Source Type: journals

Prevalence of Antiretroviral Drug Resistance in Antiretroviral-Naive IndividualsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Transmitted antiretroviral drug resistance has been an ongoing consideration even in patients who are treatment naive. The authors retrospectively selected all eligible patients from a US-based urban HIV clinic who had a genotypic resistance assay performed prior to the initiation of antiretroviral therapy. Clinically significant resistance was detected in 8% of assays, and was comparable when stratified by duration of time from diagnosis to genotypic resistance assay.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - May 29, 2009 Category: Infectious Diseases Authors: James, C. W., Moffett, L. E., Szabo, S. Tags: Article Source Type: journals

HIV Testing and Treatment Among At-Risk Drinking Injection Drug UsersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. HIV treatment programs should address at-risk drinking through screening for alcohol use and educating staff to improve the lower rate of ART reported by at-risk drinking IDUs.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - May 29, 2009 Category: Infectious Diseases Authors: Arasteh, K., Des Jarlais, D. C. Tags: Article Source Type: journals

Known to Be Positive But Not in Care: A Pilot Study From ThailandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was designed to describe persons with HIV/ AIDS (PWHAs) in Thailand who have not disclosed their HIV status to the government HIV clinics to receive medical care. Objectives were to (1) demonstrate a way to access these persons, and (2) describe their characteristics, HIV status, reasons for nondisclosure, and problems related to their self-care. Two nongovernmental organizations (NGOs) serving the nonmedical needs of PWHAs were used. In all, 22 PWHAs participated. Approximately 80% have known their HIV status for more than 1 year and 30% for more than 5 years. Almost 60% currently used recreational drugs. Reaso...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - May 29, 2009 Category: Infectious Diseases Authors: Rithpho, P., Grimes, D. E., Grimes, R. M., Senaratana, W. Tags: Article Source Type: journals

Awareness and Attitude of Health Workers at a Nigerian HIV Treatment Clinic Toward HIV/AIDS and HAART AdherenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. Adherence counselors and support staff required on-the-job training for optimum job performance.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - May 29, 2009 Category: Infectious Diseases Authors: Olowookere, S. A., Fatiregun, A. A., Osagbemi, K. G. Tags: Article Source Type: journals

Analysis of a Switch From Enfuvirtide to Raltegravir in Patients With Undetectable Viral Load: Efficacy and Quality of Life at 24 WeeksEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - April 15, 2009 Category: Infectious Diseases Authors: Sayana, S., Prosser, P., Ricaurte, J. C., Sanchez, S., Hamwi, G., Hershey-Weber, J., Chien, C., Easley, A., Nguyen, T., Wilson, L., Khanlou, H. Tags: Article Source Type: journals

Raltegravir With Unboosted Atazanavir 300 mg Twice Daily in Antiretroviral Treatment-Experienced ParticipantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report the authors present a case series of treatment-experienced patients managed with RAL + ATV given without a boosting dose of RTV. All patients tolerated this regimen over a course of 25 to 82 weeks, and had good virologic and immunologic outcome with a decrease in HIV RNA levels to <50 copies/mL and a mean CD4 count increase of 234 cells/mm3.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - April 15, 2009 Category: Infectious Diseases Authors: Gupta, S., Lataillade, M., Farber, S., Kozal, M. J. Tags: Article Source Type: journals

Relationship of Psychological Distress and Unprotected Sex Among Individuals With HIV Seeking Mental Health CareEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examined the prevalence of sexual behavior and its relationship with psychological distress among individuals with HIV who were seeking mental health care. Upon self-enrollment in HIV-related mental health care, 845 participants completed self-assessments of demographics, psychological distress, and sexual behaviors. Participants were categorized by sexual risk as determined by their reported unprotected sexual activity within the previous 30 days: receptive anal or vaginal sex (high-risk), insertive anal or vaginal sex (moderate-risk), oral sex (low-risk), and no sex (no-risk). The majority of the sample was cl...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - April 15, 2009 Category: Infectious Diseases Authors: Shacham, E., Basta, T. B., Reece, M. Tags: Article Source Type: journals

High Seroprevalence But Low Incidence of HCV Infection in a Cohort of Patients With Sexually Transmitted HIV in Andalusia, SpainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. HCV seroprevalence among sexually transmitted HIV-infected patients is more frequent than in the general population; however, incidence of HCV infection is currently low. Patients with sexually transmitted HIV coinfected with HCV have their HIV infection well controlled, but HCV infection was treated in few cases.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - April 15, 2009 Category: Infectious Diseases Authors: Palacios, R., Mata, R., Aguilar, I., Munoz, L., Rios, M. J., Vergara, S., Rivero, A., Merino, D., Lopez-Cortes, L. F., Pena, A., Santos, J., Group for the Study of Viral Hepatitis of SAEI Tags: Article Source Type: journals

Prevalence of HIV-1 Subtypes in Brazilian Children With Perinatally Acquired InfectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, 58 samples from infants infected with HIV-1 via perinatal transmission were analyzed. All the 58 samples were submitted to Nested-polymerase chain reaction of the env gene region for posterior viral genotyping using EN 70 and EN 85 (first polymerase chain reaction) and EN 80 and EN 95 (second polymerase chain reaction) primers, with the product of the 682 base pair amplification. After Nested-polymerase chain reaction for genotyping, purification of the product, and direct sequencing in a MegaBace 1000 automatic sequencer, 56 genotypes were found in the 58 HIV-1-positive children of the study, where 47 (83.9...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - April 15, 2009 Category: Infectious Diseases Authors: Molina, R. M., Torina, A. G., Biffi, K., Bismara, B. A. P., Albuquerque, D. M., Andrade, P. D., Anjos, E. B. V., Toro, A. D. C., Nolasco, M. T., Vilela, M. M. S., Costa, S. C. B. Tags: Article Source Type: journals

Iatrogenic Cushing's Syndrome in HIV-Infected Patients Receiving Ritonavir and Inhaled Fluticasone: Description of 4 New Cases and Review of the LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report 4 cases of iatrogenic Cushing's syndrome after concomitant administration of inhaled fluticasone and antiretroviral therapy including a protease inhibitor boosted with ritonavir. Although typical manifestations were present, diagnosis of Cushing's syndrome was delayed because the patients were suspected to have antiretroviral therapy-associated lipodystrophy, which shares common clinical features with Cushing's syndrome. Biochemical tests confirmed iatrogenic Cushing's syndrome and clinical symptoms resolved after stopping ritonavir or fluticasone. The differences between the clinical symptoms of Cushing's syndro...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - April 15, 2009 Category: Infectious Diseases Authors: Valin, N., De Castro, N., Garrait, V., Bergeron, A., Bouche, C., Molina, J. M. Tags: Article Source Type: journals

Immune Reconstitution Inflammatory Syndrome in a Resource-Poor SettingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The immune reconstitution inflammatory syndrome (IRIS) associated with highly active antiretroviral therapy (HAART) was studied in rural Ethiopian HIV-infected patients. Review of 1002 charts in an outpatient clinic was conducted. The median CD4 count was 89 cells/mm3. Ninety-eight patients were hospitalized after initiation of HAART, of whom 74 were hospitalized for manifestations of IRIS (ie, 7% of patients on HAART). Of the 74 patients hospitalized with IRIS, 27 patients had tuberculosis; 12 patients, cryptococcal meningitis; 7 patients, toxoplasmosis; 6 patients, pneumonia and/or effusion; and 5 patients, Pneumocystis ...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - April 15, 2009 Category: Infectious Diseases Authors: Klotz, S. A., Aziz Mohammed, A., Girmai Woldemichael, M., Worku Mitku, M., Handrich, M. Tags: Article Source Type: journals

Hematologic Changes Associated With Zidovudine Following Single-Drug Substitution From Stavudine in a Home-Based AIDS Care Program in Rural UgandaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Patients had a higher incidence of anemia and leukopenia after substitution from D4T to ZDV, but hematologic toxicity was not a major complication in this population. Patients on ZDV-containing HAART regimens are still at risk for anemia and need close monitoring.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - April 15, 2009 Category: Infectious Diseases Authors: Forna, F., Moore, D., Mermin, J., Brooks, J. T., Were, W., Buchacz, K., Campbell, J. D., Downing, R., Borkowf, C. B., Weidle, P. J. Tags: Article Source Type: journals

Adherence and Treatment Response Among HIV-1-Infected Adults Receiving Antiretroviral Therapy in a Rural Government Hospital in Southwestern UgandaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. Viral suppression was high, but counseling to include HIV disclosure to family and keeping scheduled clinic appointments may improve long-term adherence and treatment outcomes.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - April 15, 2009 Category: Infectious Diseases Authors: Bajunirwe, F., Arts, E. J., Tisch, D. J., King, C. H., Debanne, S. M., Sethi, A. K. Tags: Article Source Type: journals

IAPAC Recommendations to the Obama Administration for the US Response to the Global HIV PandemicEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - April 9, 2009 Category: Infectious Diseases Authors: Zuniga, J. M. Tags: Article Source Type: journals

The Use of Darunavir/Ritonavir as Intensification in Low Viremic HIV-Infected Patients Treated with Boosted Protease Inhibitor-Containing RegimensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - April 9, 2009 Category: Infectious Diseases Authors: Sayana, S., Hamwi, G., DenOuden, P., Easley, A., Khanlou, H. Tags: Article Source Type: journals

Developing Countries Need Better Antiretroviral DrugsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - April 9, 2009 Category: Infectious Diseases Authors: Myken, N., Sundbeck, B., Mpumilwa, G., Andersson, R. Tags: Article Source Type: journals

The Efficacy of a US-Based Medicine Recycling Program Delivering Antiretroviral Drugs WorldwideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since 1996, AID FOR AIDS International (AFAI) has collected unused antiretroviral drugs (ART) and ``recycled'' these medications to over 600 people living with human immunodeficiency virus/AIDS abroad under its AIDS Treatment Access Program. The investigators evaluated AIDS Treatment Access Program's efficacy using immunologic and virologic outcomes. Of the 404 eligible clients who had baseline and follow-up CD4 counts, mean baseline versus most recent measure was 230 + 222 cells/mm 3 versus 372 + 256 cells/mm3 (P < .01). Of the 216 eligible clients who had baseline (>400 copies/mL) and follow-up viral loads, 62% (13...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - April 9, 2009 Category: Infectious Diseases Authors: Patrick, P. A., Jibilian, A., Herasme, O., Valencia, J., Hernandez, E. C., Jurado, S., Aguais, J. Tags: Article Source Type: journals

HIV-Related Liver Disease: ARV Drugs, Coinfection, and Other Risk FactorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Highly-active antiretroviral therapy (HAART) has proven remarkably effective for prolonging the life of patients with human immunodeficiency virus (HIV). However, while most HAART agents are safe, many have the potential to cause liver toxicity. Physicians must therefore consider the possibility of drug-induced liver injury in the management of HIV-infected patients, especially those with certain risk factors such as coinfection with hepatitis B virus (HBV) or hepatitis C virus (HCV), female gender, alcohol abuse, older age, or obesity. Understanding how, when, and why drug-related liver damage occurs is key to managing th...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - April 9, 2009 Category: Infectious Diseases Authors: Puoti, M., Nasta, P., Gatti, F., Matti, A., Prestini, K., Biasi, L., Carosi, G. Tags: Article Source Type: journals

Has Prolactin a Role in the Hypogonadal Status of HIV-Infected Patients?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Most cases of hypogonadism in human immunodeficiency virus (HIV) infection are of hypophyseal— hypothalamic origin, and hyperprolactinemia, also commonly observed in HIV-infected patients, may cause hypogonadism. We studied 188 HIV-infected men who had simultaneous determinations of gonadal and hypophyseal hormones, and we found that prolactin levels were independently predictive of hypogonadism in multivariate analysis.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - April 9, 2009 Category: Infectious Diseases Authors: Collazos, J., Esteban, M. Tags: Article Source Type: journals

Seroprevalence of HIV/HBV Coinfection in Malian Blood DonorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. The coinfection rate was unexpectedly low in this blood donor population where monoinfection with HIV or HBV prevalence was high.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - April 9, 2009 Category: Infectious Diseases Authors: Tounkara, A., Sarro, Y.S., Kristensen, S., Dao, S., Diallo, H., Diarra, B., Noumsi, T.G., Guindo, O. Tags: Article Source Type: journals

Three-Year Outcome Data of Second-Line Antiretroviral Therapy in Ugandan Adults: Good Virological Response but High Rate of ToxicityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Our study confirms lopinavir/ ritonavir-based second-line regimen but with a high rate of toxicities.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - April 9, 2009 Category: Infectious Diseases Authors: Castelnuovo, B., John, L., Lutwama, F., Ronald, A., Spacek, L. A., Bates, M., Kamya, M. R., Colebunders, R. Tags: Article Source Type: journals

Outcomes of a Remote, Decentralized Health Center-Based HIV/AIDS Antiretroviral Program in Zambia, 2003 to 2007Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A cross-sectional study of patients living with HIV/ AIDS treated during 2003 to 2007 in decentralized, rural health centers in Zambia was performed to measure virological outcomes after 12 months of antiretroviral therapy and identify factors associated with virological failure. Data from 228 patients who started antiretroviral therapy >12 months prior were analyzed. In all, 93% received stavudine + lamivudine + nevirapine regimens, and median antiretroviral therapy duration was 23.5 months (interquartile range 20-28). Of the 205 patients tested for viral load, 177 (86%) had viral load <1000 copies/mL. Probability o...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - April 9, 2009 Category: Infectious Diseases Authors: Elema, R., Mills, C., Yun, O., Lokuge, K., Ssonko, C., Nyirongo, N., Mtonga, V., Zulu, H., Tu, D., Verputten, M., O'Brien, D. P. Tags: Article Source Type: journals

Staged Introduction of Antiretroviral Therapy Into a Family with Multiple HIV-Infected MembersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the successful treatment of a single family composed of 6 infected members living in a rural African setting.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - April 9, 2009 Category: Infectious Diseases Authors: Fielder, J. F., Kwatampora, L. Tags: Article Source Type: journals

Another Year ... Another Top 10 ListEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - January 21, 2009 Category: Infectious Diseases Authors: Zuniga, J. M. Tags: Article Source Type: journals

Universal Access to Antiretroviral Therapy: Are We Moving the Targets?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - January 21, 2009 Category: Infectious Diseases Authors: Ndumbe, P. M. Tags: Article Source Type: journals

No Residual Activity of Raltegravir After Development of 148 Complex Mutations In VivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - January 21, 2009 Category: Infectious Diseases Authors: Khanlou, H., Sayana, S., Acosta, E. Tags: Article Source Type: journals

Immune Reconstitution Inflammatory Syndrome Presenting as Superior Vena Cava Syndrome Secondary to Coccidioides Lymphadenopathy in an HIV-Infected PatientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 39-year-old man living with AIDS presented with a swollen face. He was found to be HIV infected after presenting with Coccidioides pneumonia 2 years previously and was placed on daily fluconazole and then on highly active antiretroviral therapy. Computed tomography confirmed superior vena cava obstruction secondary to lymphadenopathy. Biopsy confirmed coccidioidomycosis with no evidence of malignancy. To our knowledge, this is the first description of superior vena cave syndrome secondary to coccidioidomycosis and the first description of immune reconstitution inflammatory syndrome involving Coccidioides.
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - January 21, 2009 Category: Infectious Diseases Authors: Mortimer, R. B., Libke, R., Eghbalieh, B., Bilello, J. F. Tags: Article Source Type: journals

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