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Note to AuthorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 10, 2009 Category: Neurology Source Type: journals

Calendar of EventsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 10, 2009 Category: Neurology Source Type: journals

Anomalous medial origin of the anterior choroidal artery with associated aneurysmEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a patient with an aneurysm at the origin of the AchA, and an anomalous medial take off of the artery from the internal carotid artery, then a sharp lateral turn followed by a normal course toward the choroidal fissure, unreported to date to our knowledge. The aneurysm was treated successfully by endovascular therapy. The typical anatomy of the AchA, and reported variations in its origin are discussed.Thorough knowledge of the normal cerebrovascular anatomy and attention to variations play an important role in the successful management of patients with neurological vascular conditions. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 10, 2009 Category: Neurology Authors: Ronald Hammers, Lotfi Hacein-Bey, Thomas C. Origitano Tags: Short Communications Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 10, 2009 Category: Neurology Source Type: journals

Note to AuthorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 13, 2009 Category: Neurology Source Type: journals

Calendar of EventsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 13, 2009 Category: Neurology Source Type: journals

Special Issue Reviewer AcknowledgementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 13, 2009 Category: Neurology Source Type: journals

ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 13, 2009 Category: Neurology Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 13, 2009 Category: Neurology Source Type: journals

Effective immune restoration after immunosuppressant discontinuation in a lupus patient presenting progressive multifocal leukoencephalopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe biopsy-proven PML in a lupus patient receiving mycophenolate mofetil and corticosteroids. Although the patient received no antiviral treatment, the polymerase chain reaction test for JC virus became negative in cerebrospinal fluid after immunosuppressant discontinuation and the patient survived. We discuss the restoration of immune efficiency after immunosuppressant discontinuation in this case and compare the clinical, radiological and histological features with the inflammatory PML form described in human immunodeficiency virus-infected patients. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 9, 2009 Category: Neurology Authors: Guillaume Lefèvre, Viviane Queyrel, Claude-Alain Maurage, Charles Laurent, David Launay, Arnaud Lacour, Hilaire Charlanne, Sandrine Morell-Dubois, Marc Lambert, Hélène Maillard, Patrick Vermersch, Eric Hachulla, Pierre-Yves Hatron Tags: Short Communications Source Type: journals

Cardiovascular event rates in patients with cerebrovascular disease and atherothrombosis at other vascular locations: Results from 1-year outcomes in the Japanese REACH RegistryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The REduction of Atherothrombosis for Continued Health (REACH) Registry is a large, international, prospective cohort of patients with atherothrombosis or multiple (≥3) risk factors (MRFs) for atherothrombosis.Japanese patients (n=5193) were enrolled into the REACH registry between August and December 2004. One-year event rate in patients with cerebrovascular disease (CVD) was compared with that of patients with symptomatic atherothrombosis at other locations.After one year (n=5021), patients with CVD (n=1962) experienced a higher rate of non-fatal strokes than patients with coronary artery disease (CAD), perip...
Source: Journal of the Neurological Sciences - October 8, 2009 Category: Neurology Authors: Shinichiro Uchiyama, Shinya Goto, Masayasu Matsumoto, Ryozo Nagai, Hideki Origasa, Tsutomu Yamazaki, Hiroshi Shigematsu, Kazuyuki Shimada, Nobuhiro Yamada, Deepak L. Bhatt, P. Gabriel Steg, Yasuo Ikeda, on behalf of the REACH Registry Investigators Tags: Original Articles Source Type: journals

Gross-total hematoma removal of hypertensive basal ganglia hemorrhages: A long-term follow-upEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, intracerebral hematoma was evacuated with a burr hole craniectomy. The relationships of residue hematoma volume to brain edema, inflammation factors and the long-term prognosis of HBGH patients were studied.Methods: One hundred and seventy-six patients with HBGH were randomly divided into gross-total removal of hematoma (GTRH) and sub-total removal of hematoma (STRH) groups. The pre-operative and post-operative data of the patients in the two groups were compared. The pre-operative data included age, sex, hematoma volume, time from the ictus to the operation, Glasgow Coma Scale (GCS) scores, and the European...
Source: Journal of the Neurological Sciences - October 5, 2009 Category: Neurology Authors: Yi Zuo, Gang Cheng, Da-Kuan Gao, Xiang Zhang, Hai-Ning Zhen, Wei Zhang, San-Chao Xiao Tags: Original Articles Source Type: journals

Brain dysfunction in multiple chemical sensitivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Multiple Chemical Sensitivity (MCS) is a chronic acquired disorder of unknown pathogenesis. The aim of this study was to ascertain whether MCS patients present brain single photon emission computed tomography (SPECT) and psychometric scale changes after a chemical challenge. This procedure was performed with chemical products at non-toxic concentrations in 8 patients diagnosed with MCS and in their healthy controls. In comparison to controls, cases presented basal brain SPECT hypoperfusion in small cortical areas of the right parietal and both temporal and fronto-orbital lobes. After chemical challenge, cases sho...
Source: Journal of the Neurological Sciences - October 5, 2009 Category: Neurology Authors: Ramon Orriols, Roser Costa, Gemma Cuberas, Carlos Jacas, Joan Castell, Jordi Sunyer Tags: Original Articles Source Type: journals

Activation of microglia/macrophages expressing phosphorylated S6 ribosomal protein in a case of hemimegalencephaly with progressive calcification and atrophyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A 3-year-old boy with right hemimegalencephaly (HME) showed massive calcification in the subcortical white matter and progressive atrophy of the affected hemisphere. Hemispherotomy was successful in amelioration of the patient's intractable epilepsy, and a surgical specimen from the epileptic focus was examined pathologically. Disarrangement of cortical layers along with dysmorphic appearance of neurons, balloon cells in the cortex and white matter, bi-layered calcifications in the superficial cortical layer and subcortical white matter, heterotopic neurons in the white matter, and diffuse astrogliosis were noted...
Source: Journal of the Neurological Sciences - October 5, 2009 Category: Neurology Authors: Yutaka Nonoda, Yoshiaki Saito, Masayuki Itoh, Eiji Nakagawa, Kenji Sugai, Akio Takahashi, Taisuke Otsuki, Yuko Saito, Kunimasa Arima, Masashi Mizuguchi, Yu-ichi Goto, Masayuki Sasaki Tags: Original Articles Source Type: journals

Low levels of plasma soluble receptor for advanced glycation end products are associated with severe leukoaraiosis in acute stroke patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined plasma sRAGE levels associated with clinical features in acute stroke patients. Plasma sRAGE was measured in 482 patients (318 men; mean age 71years) admitted within three days of stroke onset. Median values of sRAGE were significantly different among stroke subtypes (p=0.001); 1010pg/ml in atherothrombotic infarction, 933pg/ml in lacunar, 1280pg/ml in cardioembolic infarction, 1050pg/ml in other types of infarctions, and 943pg/ml in primary intracerebral hemorrhage. Severe leukoaraiosis on brain MR images, high NIHSS scores on admission, cigarette smoking, and normal estimated glomerular filtration rate were s...
Source: Journal of the Neurological Sciences - October 5, 2009 Category: Neurology Authors: Chiaki Yokota, Kazuo Minematsu, Yasuhiro Tomii, Masaki Naganuma, Atsushi Ito, Hikaru Nagasawa, Takenori Yamaguchi Tags: Original Articles Source Type: journals

Validation of the Parkinson's disease sleep scale in Japanese patients: A comparison study using the Pittsburgh Sleep Quality Index, the Epworth Sleepiness Scale and PolysomnographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we sought to examine the relationship between the results from the PDSS with those from the Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale (ESS), and polysomnography (PSG) in Japanese PD patients.Subjects and methods: Subjects were 79 PD patients and 79 age and gender matched controls. The length of morbidity in patients with PD was 8.4±8.0years, and their Hoehn and Yahr grade was 2.9±1.0. All subjects completed the PDSS, PSQI, and ESS questionnaires, and we compared the results from patients with PD to controls. We also evaluated the correlation among the PDSS, PSQI, and ESS in patient...
Source: Journal of the Neurological Sciences - October 5, 2009 Category: Neurology Authors: Yusuke Uemura, Takashi Nomura, Yuichi Inoue, Mika Yamawaki, Kenichi Yasui, Kenji Nakashima Tags: Original Articles Source Type: journals

Multiple sclerosis, osteoporosis, and vitamin DEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Multiple sclerosis (MS) is associated with reduced bone mass and higher frequency of osteoporosis. Although high-dose short-term intravenous glucocorticoid regimens cause a decrease in bone formation, this effect is usually reversible and osteoporosis in MS patients may be independent of the short-term corticosteroid treatment. Clinical evidence suggests an important role of vitamin D as a modifiable risk factor in MS. Low circulating levels of vitamin D have been found in MS patients, especially during relapses, suggesting that vitamin D could be involved in the regulation of the clinical disease activity. Vitam...
Source: Journal of the Neurological Sciences - October 5, 2009 Category: Neurology Authors: Chrissa Sioka, Athanassios P. Kyritsis, Andreas Fotopoulos Tags: Reviews Source Type: journals

Multiple sclerosis associated with Leber's Hereditary Optic NeuropathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The cause of multiple sclerosis is unknown although it is recognised to involve an inflammatory process associated with demyelinating plaques and more widespread neurodegeneration. It appears to have become progressively more common in females which is further discussed in this issue, and genetic factors, as identified to date, appear to play only a moderate role. One curious observation is that Leber's Hereditary Optic Neuropathy (LHON), a rare genetic syndrome, presents clinically overwhelmingly in males, but can be associated with an MS-like illness and when it does it occurs mainly in females. It is interesti...
Source: Journal of the Neurological Sciences - October 4, 2009 Category: Neurology Authors: Jacqueline Palace Tags: Papers Presented Source Type: journals

Methylenetetrahydrofolate reductase polymorphisms and plasma homocysteine in levodopa-treated and non-treated Parkinson's disease patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined whether connecting both polymorphisms influences the effect of levodopa on Hcy. MTHFR genotypes and Hcy, vitamin B12, and folate levels were determined in 48 levodopa-treated PD patients (PD-L), 28 non-treated PD patients (PD-N) and 110 controls. Hcy was remarkably higher in PD-L than in PD-N and controls (p (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 29, 2009 Category: Neurology Authors: Rey-Yue Yuan, Jau-Jiuan Sheu, Jia-Ming Yu, Chaur-Jong Hu, Ing-Jy Tseng, Chun-Sum Ho, Ching-Ying Yeh, Ya-Lin Hung, Tsuey-Ru Chiang Tags: Original Articles Source Type: journals

Acute limbic encephalitis and glutamic acid decarboxylase antibodies: A reality?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a 30-year-old male with acute LE and GAD-Ab, with follow-up during 2years of cognitive status including verbal episodic memory, number of seizures recorded by high-resolution video-EEG, brain MRI, 2-[18F]-fluoro-2-deoxyglucose PET and GAD-Ab titres. Treatment with corticosteroids, IV immunoglobulins, immunosuppressors and antiepileptic drugs resulted in improved memory status, disappearance of seizures and decreased GAD-Ab titres. Review of the other cases of literature and this case is in favour of the existence of autoimmune LE associated with GAD-Ab and supports the link between memory, temporal seizures and...
Source: Journal of the Neurological Sciences - September 28, 2009 Category: Neurology Authors: F. Blanc, E. Ruppert, C. Kleitz, M.P. Valenti, B. Cretin, R.L. Humbel, J. Honnorat, I.J. Namer, E. Hirsch, L. Manning, J. de Seze Tags: Original Articles Source Type: journals

Role of the Oral Glucose Tolerance Test (OGTT) in the idiopathic restless legs syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our study suggests that IGT (prediabetes) is frequently associated with idiopathic RLS. We propose to perform a 2h-OGTT in idiopathic RLS patients with normal fasting glycaemia. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 28, 2009 Category: Neurology Authors: Domenico Bosco, Massimiliano Plastino, Antonietta Fava, Maria Ettore, Francesca Bosco, Caterina Ermio, Federico Tallarigo, Domenico Pirritano, Domenico Consoli Tags: Original Articles Source Type: journals

European Charcot Foundation Lecture: The natural history of multiple sclerosis and genderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The role of gender in the natural history of multiple sclerosis (MS) is multi-faceted. Earliest debate on this topic was about the sex ratio (female:male) among affected individuals. It was only clearly shown within the last 4 decades that females are more often affected. The sex ratio continues to intrigue researchers. An observed increase in the sex ratio among more recently born MS patients has now been taken as a clear indication that the rate of MS is truly increasing in many geographical areas. This temporal increase in females has been relatively rapid, implicating environmental rather than genetic risk fa...
Source: Journal of the Neurological Sciences - September 27, 2009 Category: Neurology Authors: A.D. Sadovnick Tags: Papers Presented Source Type: journals

Cerebrospinal fluid levels of chemokines in HIV infected patients with and without opportunistic infection of the central nervous systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the profile of chemokines in CSF of HIV patients may differ according to the modality of the presented opportunistic infection and according to other biological markers, such as viral load in CSF. These differences are probably related to different patterns of neuroinflammatory responses displayed by patients with different opportunistic neurological infections. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 27, 2009 Category: Neurology Authors: Paulo Pereira Christo, Márcia de Carvalho Vilela, Thales Lage Bretas, Renan Barros Domingues, Dirceu Bartolomeu Greco, José Antonio Livramento, Antonio Lucio Teixeira Tags: Original Articles Source Type: journals

Relationship between neuropsychological outcome and DBS surgical trajectory and electrode locationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results provide preliminary evidence that 6months following bilateral STN DBS cognitive and emotional changes may be related to the surgical trajectory and electrode placement. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 23, 2009 Category: Neurology Authors: Michele K. York, Elisabeth A. Wilde, Richard Simpson, Joseph Jankovic Tags: Original Articles Source Type: journals

Susceptibility-weighted imaging for differential diagnosis of cerebral vascular pathology: A pictorial reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a review with selected cases to demonstrate the usefulness of this new neuroimaging technique in improving the diagnosis of cerebral vascular pathology. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 23, 2009 Category: Neurology Authors: Yu-Kun Tsui, Fong Y. Tsai, Anton N. Hasso, Fred Greensite, Binh V. Nguyen Tags: Reviews Source Type: journals

Hemibody mirror movements in hemiparkinsonism–hemiatrophy syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report describes a patient with the HPHA phenotype who exhibited MM, a feature that has not been previously reported in this syndrome. Surface electromyography (EMG) was used to illustrate the virtually simultaneous occurrence of voluntary and involuntary movements. Needle EMG was used to diagnose a spinal accessory neuropathy. Pathological mirroring or overflow movement of the orbicularis oculi muscle is also hypothesized. The clinical features are demonstrated on video. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 22, 2009 Category: Neurology Authors: David S. Silvers, Daniel L. Menkes Tags: Short Communications Source Type: journals

Intrafamilial clinical phenotypic heterogeneity with MAPT gene splice site IVS10+16C>T mutationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Two families with frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) resulting from the microtubule associated protein tau (MAPT) gene IVS10+16C>T splice site mutation are reported, members of which showed variable clinical phenotypes at presentation. Possible explanations for the intra- and interfamilial clinical heterogeneity associated with this MAPT mutation are discussed. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 22, 2009 Category: Neurology Authors: A.J. Larner Tags: Short Communications Source Type: journals

Changes in risk factors and preventive treatments by stroke subtypes over 20years: A population-based studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In order to evaluate progress in preventive therapeutic strategies, and to identify potential targets for improvement, it is essential to assess changes in the risk factors and preventive treatment of stroke over time. All of the strokes occurring within the population of Dijon, France (150,000 inhabitants), were prospectively ascertained from 1985 to 2004. Changes in stroke risk factors and preventive medications were analyzed by stroke subtypes. We recorded 725 lacunar infarcts (LI), 497 cardioembolic (CE) strokes, 2054 ischemic stroke from atheroma of large arteries or from other and undetermined causes (OIS),...
Source: Journal of the Neurological Sciences - September 22, 2009 Category: Neurology Authors: Yannick Béjot, Guy-Victor Osseby, Vincent Gremeaux, Jérôme Durier, Olivier Rouaud, Thibault Moreau, Maurice Giroud Tags: Original Articles Source Type: journals

Brain-derived neurotrophic factor and TrkB receptor in experimental autoimmune encephalomyelitis and multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The interaction between the immune and nervous systems can be both detrimental and beneficial. Experimental autoimmune encephalomyelitis (EAE) is an animal model of autoimmune demyelination that histologically and clinically mimics multiple sclerosis (MS). Myelin-reactive T cells produce and release brain-derived neurotrophic factor (BDNF) directly in the central nervous system, which stimulates tissue repair after traumatic injury. In EAE and MS, T cells in the vicinity of actively demyelinating lesions express BDNF, suggesting a neuroinflammatory reaction that is designed to limit brain damage and contribute to...
Source: Journal of the Neurological Sciences - September 17, 2009 Category: Neurology Authors: Lorenzo De Santi, Pasquale Annunziata, Edoardo Sessa, Placido Bramanti Tags: Reviews Source Type: journals

Fluorodeoxyglucose positron emission tomography (FDG-PET) is useful in the diagnosis of neurosarcoidosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A 45-year-old man presented with a progressive transverse spinal cord syndrome. MRI scanning revealed bitemporal and multiple spinal lesions with significant enhancement after gadolinium administration mimicking an acute disseminated encephalomyelitis. CSF analyses showed a lymphocytic pleocytosis. After treatment with high dose steroids clinical improvement was observed with a secondary decline shortly thereafter. MRI rescanning showed no remarkable alterations of the lesions. Further diagnostic work-up included a fluorodeoxyglucose positron emission tomography (FDG-PET) of the whole body to search for occult in...
Source: Journal of the Neurological Sciences - September 16, 2009 Category: Neurology Authors: Seza Bolat, Georg Berding, Reinhard Dengler, Martin Stangel, Corinna Trebst Tags: Short Communications Source Type: journals

Radiological features of craniopharyngiomas located in the posterior fossaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PFCPs are well demarcated, contrast-enhanced tumors, typically with cystic parts or purely cyst. Most of PFCPs demonstrate a retrostalk growth pattern and characteristic connection. Tumor with cystic component arises from sellar region and then extends to posterior fossa, which should be strongly suspected as a PFCP. The combined supra- and infratentorial approach is an ideal choice for surgical management of PFCP. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 16, 2009 Category: Neurology Authors: Liangxue Zhou, Qiang Li, Linli Luo, Jianguo Xu, Yuekang Zhang, Tianwu Chen, Yuquan Wei, Chao You Tags: Original Articles Source Type: journals

Clinical applicability of a mathematical model in assessing the functional ability of the communicating arteries of the circle of WillisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our data indicate that functional ability of the Willisian collaterals depends on morphological and functional parameters, and is therefore better assessed by a functional method, such as TCCD, than by a solely morphological one, such as cerebral angiography. Mathematically based circulation modeling, when it will be possible, could be a more comprehensive tool for delineating patients at a higher risk for hemodynamic cerebrovascular insufficiency. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 16, 2009 Category: Neurology Authors: László Orosz, Arjan W. Hoksbergen, Csilla Molnár, Péter Siró, Francis Cassot, Jean-Pierre Marc-Vergnes, Béla Fülesdi Tags: Original Articles Source Type: journals

Is RNA manipulation a viable therapy for spinal muscular atrophy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Childhood spinal muscular atrophy (SMA) is an autosomal recessive disorder characterised by loss of the alpha motor neurones of the spinal cord. SMA is cause by mutations in the survival motor neuron (SMN) gene. There are two copies of the SMN gene: SMN1 and SMN2. The two genes differ by only 11 nucleotides at the genomic level. One of these is a C to T single nucleotide polymorphism (SNP) at position 6 in exon 7. This change alters an exon splicing enhancer in exon 7, meaning that while SMN1 expresses exclusively full-length protein containing exon 7, SMN2 is predominantly alternatively spliced and expresses a t...
Source: Journal of the Neurological Sciences - September 16, 2009 Category: Neurology Authors: Christopher Horne, Philip J. Young Tags: Reviews Source Type: journals

The Prevention of Post-Partum Relapses with Progestin and Estradiol in Multiple Sclerosis (POPART'MUS) trial: Rationale, objectives and state of advancementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Multiple sclerosis (MS) affects 1 in 1000 people in western countries, mainly women in their childbearing years. It is an autoimmune disease of the central nervous system, which results in a chronic focal inflammatory response with subsequent demyelination and axonal loss. It usually begins with acute episodes of neurological dysfunction, the relapses, followed by periods of partial or complete remission. This relapsing–remitting phase is usually followed by a steady, continuous and irreversible worsening of the neurological dysfunction, which characterizes the progressive phase of the disease.Recent prospectiv...
Source: Journal of the Neurological Sciences - September 15, 2009 Category: Neurology Authors: S. Vukusic, I. Ionescu, M. El-Etr, M. Schumacher, E.E. Baulieu, C. Cornu, C. Confavreux, for the POPART'MUS study group Tags: Papers Presented Source Type: journals

Primary leptomeningeal anaplastic oligodendroglioma with a 1p36–19q13 deletion: Report of a unique case successfully treated with TemozolomideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a 60-year-old man with a prior history of an epileptic seizure three years earlier, who was referred because of depression and a rapid evolving cognitive impairment. Brain MRI showed a diffuse right parieto-occipital subarachnoid enhancing lesion without intra-axial extension. The diagnosis of an anaplastic oligodendroglioma (WHO grade 3) was made on pathological examination. Molecular analysis using the FISH technique revealed a combined deletion of chromosomes 1p36 and 19q13. A rapid progression of the lesion was shown on MRI with leptomeningeal spinal metastases. The patient was treated with Temozolomide (TM...
Source: Journal of the Neurological Sciences - September 14, 2009 Category: Neurology Authors: A. Michotte, C. Chaskis, J. Sadones, P. In't Veld, B. Neyns Tags: Short Communications Source Type: journals

Room tilt illusion in Parkinson's disease: Loss of spatial reference frames?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a patient with Parkinson's disease who developed typical room tilt illusion. Single photon emission computed tomography demonstrated hypoperfusion of the posterior area of the right intraparietal sulcus, which is related to discriminating the surface orientation of three-dimensional objects. Therefore, it is possible that dysfunction of this region of the intraparietal sulcus may have disrupted the integration of spatial reference frames for internal representation of the surrounding space in our patient, and thus may have caused room tilt illusion. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 14, 2009 Category: Neurology Authors: Ryuichiro Hayashi, Shigeki Yamaguchi, Yasushi Katsumata, Masaru Mimura Tags: Short Communications Source Type: journals

Friedreich's ataxia: Oxidative stress and cytoskeletal abnormalitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we analysed the glutathionylation of proteins in the spinal cord of patients with FRDA and the distribution of tubulin and neurofilaments in the same area. We found, for the first time, a significant rise of the dynamic pool of tubulin as well as abnormal distribution of the phosphorylated forms of human neurofilaments in FRDA motor neurons. In the same cells, the cytoskeletal abnormalities co-localized with an increase in protein glutathionylation and the mitochondrial proteins were normally expressed by immunocytochemistry. Our results suggest that in FRDA oxidative stress causes abnormally increased prote...
Source: Journal of the Neurological Sciences - September 14, 2009 Category: Neurology Authors: Marco Sparaco, Laura Maria Gaeta, Filippo Maria Santorelli, Chiara Passarelli, Giulia Tozzi, Enrico Bertini, Alessandro Simonati, Francesco Scaravilli, Franco Taroni, Charles Duyckaerts, Michele Feleppa, Fiorella Piemonte Tags: Original Articles Source Type: journals

Predisposing factors for acute deterioration of minor ischemic strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In this study, the predisposing factors for acute deterioration in minor ischemic stroke were atherothrombotic brain infarction; high blood pressure; elevated serum glucose level; and paralysis, vertigo, and dizziness. Once patients with minor ischemic stroke deteriorated, their functional outcome at discharge was significantly worse than those who had not deteriorated. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 9, 2009 Category: Neurology Authors: Toshiyasu Ogata, Masahiro Yasaka, Yoshiyuki Wakugawa, Setsuro Ibayashi, Yasushi Okada Tags: Original Articles Source Type: journals

Neuromyelitis optica: Effect of genderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Neuromyelitis optica is a distinct CNS demyelinating disease associated with the autoantibody NMO-IgG, which targets the water channel aquaporin-4. Neuromyelitis optica may be distinguished from typical multiple sclerosis on the basis of key clinical and neuroimaging characteristics in addition to detection of NMO-IgG. The disease has an even stronger female predilection than does multiple sclerosis, with a reasonably consistent female to male gender ratio of >3:1 reported from samples of diverse racial and regional populations worldwide. The gender distribution appears to be similar in both childhood-onset and a...
Source: Journal of the Neurological Sciences - September 8, 2009 Category: Neurology Authors: Dean M. Wingerchuk Tags: Papers Presented Source Type: journals

Semi-intensive stroke unit versus conventional care in acute ischemic stroke or TIA — A prospective study in GermanyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: German Society of Neurology's stroke-unit concept includes a specialized stroke-unit team and advanced monitoring facilities in the early phase of stroke. Our aim was to evaluate the effectiveness of this semi-intensive stroke-unit (SI-SU) concept as compared with conventional care (CC) for patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA).Over a 20-month period starting in March 2001, 755 patients with AIS or TIA were treated under SI-SU (n=393) or CC (n=362) conditions within an observational study. All patients were admitted within 24h after symptom onset. Patients' outcomes were ass...
Source: Journal of the Neurological Sciences - September 8, 2009 Category: Neurology Authors: Andreas Walter, Guenter Seidel, Andreas Thie, Heiner Raspe Tags: Original Articles Source Type: journals

Note to AuthorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 7, 2009 Category: Neurology Source Type: journals

Calendar of EventsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 7, 2009 Category: Neurology Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 7, 2009 Category: Neurology Source Type: journals

Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This book is a multiauthored survey of infections by neurotropic viruses. It is not a conventional textbook as such, but rather a series of chapters on various topics in neurovirology. These topics are put into three groups: RNA viruses, DNA viruses and more general topics: diagnostic methods and management, epidemiology, and other topics not generally covered in conventional textbooks. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 7, 2009 Category: Neurology Authors: Alex Tselis Tags: Book Review Source Type: journals

Low uric acid levels in serum of patients with ALSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Reply from the authors: We would like to thank Ikeda et al. for the interest shown in our paper . Similar to our study, they report that uric acid levels were lower in patients with amyotrophic lateral sclerosis (ALS) as compared to well-matched controls. They did not find a correlation between the rate of decline of ALSFRS over 1 year and the rate of change in serum uric acid levels. In our study no correlation was found between the ALSFRS-R and the serum uric acid levels at the time of the first and second blood test or between the ALSFRS-R difference and the uric acid level difference between the tests. Therefore, the...
Source: Journal of the Neurological Sciences - September 7, 2009 Category: Neurology Authors: Vivian E. Drory, Beatrice Nefussy Tags: Letters to the Editor and Responses Source Type: journals

A case of Sturge–Weber syndrome with symptomatic hemiplegic migraine: Clinical and multimodality imaging data during a prolonged attackEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Hemiplegic migraine (HM) in the setting of Sturge–Weber syndrome (SWS) has been previously described. Here, we report clinical and multimodal imaging data on a 21-year-old man with SWS and HM, who presented during an acute HM attack with a dense left-hemispheric syndrome (expressive aphasia and right sensorimotor hemiplegia), lasting for more than 10days. Repeated EEGs were without evidence of status epilepticus. Consistent with previous findings in prolonged migraine aura, perfusion computed tomography demonstrated left-hemispheric hyperperfusion on day 7. 18F-FDG positron emission tomography (day 7) revealed ...
Source: Journal of the Neurological Sciences - September 7, 2009 Category: Neurology Authors: Tobias Freilinger, Nils Peters, Jan Rémi, Jennifer Linn, Marcus Hacker, Andreas Straube, Thomas Pfefferkorn Tags: Short Communications Source Type: journals

Age-related alterations in the expression of MTH2 in the hippocampus of the SAMP8 mouse with learning and memory deteriorationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: MutT-related proteins degrade 8-oxo-7,8-dihydrodeoxyguanosine triphosphate (8-oxo-dGTP), a mutagenic substrate for DNA synthesis in the nucleotide pool, thereby preventing DNA replication errors. MTH2 (Mut T homolog 2), which belongs to this family of proteins, possesses 8-oxo-7,8-dihydro-2′-deoxyguanosine triphosphatase (8-oxo-dGTPase) activity and appears to function in the protection of the genetic material from the untoward effects of endogenous oxygen radicals. To examine the roles of MTH2 in the aging process, we used the senescence-accelerated prone mouse 8 (SAMP8), which exhibits early aging syndromes a...
Source: Journal of the Neurological Sciences - September 7, 2009 Category: Neurology Authors: Jun-De Zheng, Ai-Lian Hei, Ping-Ping Zuo, Yi-Long Dong, Xiao-Ning Song, Yasumitsu Takagi, Mutsuo Sekiguchi, Jian-Ping Cai Tags: Original Articles Source Type: journals

Impairment of perinatal hypoxia–ischemia to the preterm brainstemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study assessed functional integrity of the brainstem at term in preterm infants after perinatal hypoxia–ischemia to shed light on the influence of hypoxia–ischemia on the preterm brainstem. We recruited sixty-eight preterm infants after perinatal hypoxia–ischemia, ranging in gestation 28–35weeks. Brainstem evoked response was studied at term age (37–42weeks postconceptional age) with 91–910/s clicks using the maximum length sequence technique. Compared with healthy preterm infants, the preterm infants after perinatal hypoxia–ischemia showed a significant increase in I–V interval at very high rates 455 ...
Source: Journal of the Neurological Sciences - September 7, 2009 Category: Neurology Authors: Ze D. Jiang, Dorothea M. Brosi, C. Chen, Andrew R. Wilkinson Tags: Original Articles Source Type: journals

In-vivo animation of midazolam-induced electrocorticographic changes in humansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Previous human studies have demonstrated that midazolam-induced signal changes on scalp EEG recording include widespread augmentation of sigma-oscillations and that the amplitude of such oscillations is correlated to the severity of midazolam-induced amnesia. Still unanswered questions include whether midazolam-induced sigma-augmentation also involves the medial temporal region, which plays a role in memory encoding. Taking advantage of rare and unique opportunities to monitor neuronal activities using intracranial electrocorticography (ECoG) recording, we determined how intravenous administration of midazolam el...
Source: Journal of the Neurological Sciences - September 7, 2009 Category: Neurology Authors: Masaaki Nishida, Sandeep Sood, Eishi Asano Tags: Original Articles Source Type: journals

Necrobacillosis resulting in isolated carotid thrombosis and massive stroke: A unique Lemierre variant?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a healthy, young adult male patient who developed isolated carotid artery thrombosis and occlusion following acute pharyngitis due to Fusobacterium necrophorum. We believe this is the first case of isolated occlusion of internal carotid artery (ICA) with F. necrophorum without associated internal jugular vein (IJV) thrombosis. Lemierre's syndrome (LS) is characterized by a history of recent oropharyngeal infection in previously healthy individuals, clinical or radiological evidence of internal jugular vein thrombosis, and isolation of anaerobic pathogens, mainly F. necrophorum. We discuss literature on this rar...
Source: Journal of the Neurological Sciences - September 7, 2009 Category: Neurology Authors: Munish Kumar Goyal, Gyanendra Kumar, Robert Burger Tags: Original Articles Source Type: journals