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Possible role for glomerular-derived angiotensinogen in nephrotic syndrome
Conclusion: It is conceivable that the promoted local RAS action participated in the glomerular dysfunction, and that ARB treatment ameliorated slit diaphragm injury by inhibiting the positive feedback loop of the activated local Ang II action. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 7, 2016 Category: Biomedical Science Authors: Yamazaki, M., Fukusumi, Y., Kayaba, M., Kitazawa, Y., Takamura, S., Narita, I., Kawachi, H. Tags: Original Article Source Type: research

Effects of exendin-4 on the intrarenal renin-angiotensin system and interstitial fibrosis in unilateral ureteral obstruction mice: Exendin-4 and unilateral ureteral obstruction
Conclusion: Our present study indicates for the first time that exendin-4 exerts renoprotective effects in an experimental model of UUO, partly through regulating the balance of the intrarenal renin-angiotensin system and then inhibiting the Ang II-mediated TGF-β1/Smad3 signaling pathway. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 1, 2016 Category: Biomedical Science Authors: Le, Y., Zheng, Z., Xue, J., Cheng, M., Guan, M., Xue, Y. Tags: Original Article Source Type: research

Cross-talk between AMP-activated protein kinase and renin-angiotensin system in uninephrectomised rats
Conclusions: Uninephrectomy-induced RAS activation and AMPK inhibition in the remnant kidney could be substantially corrected by RAS blockade, suggesting a cross-talk between AMPK and RAS components in uninephrectomised rats. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - October 25, 2016 Category: Biomedical Science Authors: Yang, K.-K., Sui, Y., Zhou, H.-R., Shen, J., Tan, N., Huang, Y.-M., LI, S.-S., Pan, Y.-H., Zhang, X.-X., Zhao, H.-L. Tags: Original Article Source Type: research

Inhibitory effects of telmisartan on culture and proliferation of and Kv1.3 potassium channel expression in peripheral blood CD4+ T lymphocytes from Xinjiang Kazakh patients with hypertension
Conclusions: Telmisartan may potentially regulate hypertensive inflammatory responses by inhibiting T-lymphocytic proliferation and Kv1.3 potassium channel expression in CD4+ T lymphocytes. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - October 18, 2016 Category: Biomedical Science Authors: Huang, S.-S., Zhang, Q.-B., Yuan, Q.-Y., He, S.-L., Zhang, Y.-M. Tags: Original Article Source Type: research

Testosterone downregulates angiotensin II type-2 receptor via androgen receptor-mediated ERK1/2 MAP kinase pathway in rat aorta
Conclusion: Androgens downregulate AT2R expression levels in aorta, in vivo and ex vivo. The androgen receptor-mediated ERK1/2 MAP kinase-signaling pathway may be a key mechanism by which testosterone downregulates AT2R expression, implicating androgens’ contributing role to gender differences in vascular AT2R expression. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - October 18, 2016 Category: Biomedical Science Authors: Mishra, J. S., Hankins, G. D., Kumar, S. Tags: Original Article Source Type: research

Quantification of systemic renin-angiotensin system peptides of hypertensive black and white African men established from the RAS-Fingerprint(R)
Conclusions: The observed differences between circulating RAS components, which are reflected via equilibrium angiotensin levels, point to a distinctive molecular regulation of the RAAS in the two study cohorts. The increased peripheral resistance observed in hypertensive black individuals might take over a dominant role in control of blood pressure in this study population. A novel highly sensitive LC-MS/MS method resolved the issue of peptide recovery variations during sample preparation by using internal standards for each individual angiotensin metabolite. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - October 11, 2016 Category: Biomedical Science Authors: van Rooyen, J., Poglitsch, M., Huisman, H., Mels, C., Kruger, R., Malan, L., Botha, S., Lammertyn, L., Gafane, L., Schutte, A. Tags: Original Article Source Type: research

Mitochondrial-dependent mechanisms are involved in angiotensin II-induced apoptosis in dopaminergic neurons
Conclusion: This study demonstrates that Ang II triggers mitochondrial-dependent apoptosis via facilitating mPTP opening through an AT1 receptor-mediated fashion in dopaminergic neurons. These findings give insight into the effect of Ang II in the etiology of PD, and reinforce the application of AT1 receptor antagonists for PD treatment. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - October 10, 2016 Category: Biomedical Science Authors: Ou, Z., Jiang, T., Gao, Q., Tian, Y.-Y., Zhou, J.-S., Wu, L., Shi, J.-Q., Zhang, Y.-D. Tags: Original Article Source Type: research

Adipocytes do not significantly contribute to plasma angiotensinogen
In conclusion, adipocyte-derived Agt has essentially no contribution to the plasma concentration and no impact on blood pressure compared to liver-derived Agt. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - October 9, 2016 Category: Biomedical Science Authors: Koizumi, M., Niimura, F., Fukagawa, M., Matsusaka, T. Tags: Original Article Source Type: research

Zofenopril and ramipril in patients with left ventricular systolic dysfunction after acute myocardial infarction: A propensity analysis of the Survival of Myocardial Infarction Long-term Evaluation (SMILE) 4 study
Conclusions: In the SMILE-4 study the propensity analysis confirmed the efficacy of zofenopril in the prevention of long-term cardiovascular outcomes irrespective of the cardiovascular risk profile of post-AMI patients. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - October 4, 2016 Category: Biomedical Science Authors: Borghi, C., Omboni, S., Novo, S., Vinereanu, D., Ambrosio, G., Ambrosioni, E., on behalf of the SMILE-4 Working Party Tags: Original Article Source Type: research

Volume regulatory hormones and plasma volume in pregnant women with sickle cell disorder
Conclusions: The lower plasma renin concentration at 16 weeks with HbSS could be either primary or secondary to vasoconstriction related to inadequate vasodilator activity. The contracted plasma volume might then stimulate aldosterone synthesis by non-angiotensin II dependent stimulation. Studies of vasodilators such as nitric oxide, vasodilator eicosanoids or the PlGF/VEGF/sFlT-1 axis in pregnant HbSS and HbAA women will test this hypothesis. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 26, 2016 Category: Biomedical Science Authors: Afolabi, B. B., Oladipo, O. O., Akanmu, A. S., Abudu, O. O., Sofola, O. A., Broughton Pipkin, F. Tags: Original Article Source Type: research

Efficacy of lycopene on modulation of renal antioxidant enzymes, ACE and ACE gene expression in hyperlipidaemic rats
Conclusions: This finding suggests that supplementation of lycopene is effective for renal antioxidant enzymes, ACE gene expression and ACE serum level in hyperlipidaemic rats. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 26, 2016 Category: Biomedical Science Authors: Khan, N. I., Noori, S., Mahboob, T. Tags: Original Article Source Type: research

miR-205 mediates the inhibition of cervical cancer cell proliferation using olmesartan
Conclusion: This result provides a new idea on the anti-tumor mechanism of olmesartan, which may be used as a novel therapeutic target of cervical cancer. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 18, 2016 Category: Biomedical Science Authors: Yue, Z., Yun-shan, Z., Feng-xia, X. Tags: Original article Source Type: research

Overexpression of angiotensinogen downregulates aquaporin 1 expression via modulation of Nrf2-HO-1 pathway in renal proximal tubular cells of transgenic mice
Conclusions: Angiotensinogen-mediated downregulation of aquaporin 1 and Nrf2 signalling may play an important role in intrarenal renin–angiotensin system-induced hypertension and kidney injury. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 14, 2016 Category: Biomedical Science Authors: Chang, S.-Y., Lo, C.-S., Zhao, X.-P., Liao, M.-C., Chenier, I., Bouley, R., Ingelfinger, J. R., Chan, J. S., Zhang, S.-L. Tags: Original Article Source Type: research

Progenitor cell secretory products exert additive renoprotective effects when combined with ace inhibitors in experimental CKD
Conclusions: Early outgrowth cell-derived factors exert additive renoprotective effects on top of angiotensin-converting enzyme inhibitor therapy in experimental chronic kidney disease, providing the rationale for clinical trials of early outgrowth cell-based therapies for chronic kidney disease. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 14, 2016 Category: Biomedical Science Authors: Kepecs, D. M., Yuen, D. A., Zhang, Y., Thai, K., Connelly, K. A., Gilbert, R. E. Tags: Original Article Source Type: research

The association of ACE gene polymorphism with diabetic kidney disease and renoprotective efficacy of valsartan
Conclusions: In T2DM patients, the ACE I/D polymorphism was associated with onset of DKD. Furthermore, the ACE I/D polymorphism influenced the renoprotective response to valsartan: Patients with the DD genotype benefitted the most from this treatment. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 14, 2016 Category: Biomedical Science Authors: Wang, Y., Peng, W., Zhang, X., Qiao, H., Wang, L., Xu, Z., Wu, C. Tags: Original Article Source Type: research