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Association of angiotensin-converting enzyme gene promoter single nucleotide polymorphisms and haplotype with major depression in a northeastern Thai populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. In the present investigation, an association between the –240A allele and a reduced risk for MDD was observed, but the genotype distributions of controls were only just in marginal agreement with Hardy-Weinberg equilibrium.The T-T haplotype in the ACE gene was significantly associated with an increased risk for MDD. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - August 26, 2009 Category: Biomedical Science Authors: Angunsri, R., Sritharathikhun, T., Suttirat, S., Tencomnao, T. Tags: Article Source Type: journals

Angiotensin II type 1 receptor gene polymorphism in myocardial infarction patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. The angiotensin II type 1 receptor CC genotype is not a risk factor for myocardial infarction in patients in a South Indian population. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - August 26, 2009 Category: Biomedical Science Authors: Bhoomi Reddy Pullareddy, , Baddela Muni Venkata Srikanth Babu, , Kolla Venkata Karunakar, , Yasovanthi, J., Potham Sampath Kumar, , Sharath, A., Jyothy, A. Tags: Article Source Type: journals

Electrocardiographic left ventricular hypertrophy regression induced by an angiotensin receptor blocker-based regimen in hypertensive patients with diabetes: data from the SARA studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. The prevalence of ECG-LVH detected by CorP was higher in diabetics. Diabetics achieved higher reductions in ECG-LVH prevalence than non-diabetics with a candesartan-based regimen. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - August 26, 2009 Category: Biomedical Science Authors: Barrios, V., Escobar, C., Calderon, A., Echarri, R., Barrios, S., Navarro-Cid, J. Tags: Article Source Type: journals

Comparative effects of aliskiren-based and ramipril-based therapy on the renin system during long-term (6 months) treatment and withdrawal in patients with hypertensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Aliskiren-based therapy produced sustained BP and PRA reductions over 26 weeks; ramipril-based therapy lowered BP and increased PRA. PRA reductions persisted 4 weeks after stopping aliskiren, suggesting an inhibitory effect beyond the elimination half-life of the drug. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - August 26, 2009 Category: Biomedical Science Authors: Andersen, K., Weinberger, M. H, Constance, C. M, Ali, M. A, Jin, J., Prescott, M. F, Keefe, D. L Tags: Article Source Type: journals

Efficacy in angiotensin receptor blockade: a comparative review of data with olmesartanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A range of angiotensin II receptor blockers (ARB) is available, and analyses suggest there are differences between agents in terms of antihypertensive efficacy and 24-hour blood pressure control.This review assesses the data comparing olmesartan with other ARBs in terms of blood pressure reductions, goal achievement, 24-hour control and speed of onset. Olmesartan seems to have a more favourable efficacy profile relative to standard doses of the ARBs used in comparative studies; results consistent with the high degree of blockade of the angiotensin II type 1 receptor for olmesartan.Taken together, there might be differences...
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - August 26, 2009 Category: Biomedical Science Authors: Redon, J., Fabia, M. J. Tags: Article Source Type: journals

Muscarinic effects and foetal cardiovascular and hormonal responses in uteroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. The results suggest that foetal automatic systems, not those hormonal factors tested, play a major role in cholinergic mechanisms mediating cardiovascular control. Furthermore, the data provide new information on how muscarinic inhibition affects renin-angiotensin system and adrenal cortex functions. Key words: aldosterone, angiotensin-converting enzyme, autonomic regulation, foetus (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - August 26, 2009 Category: Biomedical Science Authors: Jianli Zheng, , Weili Yang, , Li Cao, , Shigang Li, , Yuying Zhang, , Zhen Wan, , Caiping Mao, Tags: Article Source Type: journals

Aldosterone-induced endothelial dysfunction of rat aorta: role of poly(ADP-ribose) activationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. Our results indicate that PARP activation in the vascular system may be a contributory factor to the impaired endothelial function associated with aldosterone administration. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - August 26, 2009 Category: Biomedical Science Authors: Tasatargil, A., Tekcan, M., Celik-Ozenci, C., Ece Gungor, N., Dalkiran, B. Tags: Article Source Type: journals

Angiotensin II does not influence expression of sarcoplasmic reticulum Ca2 + ATPase in atrial myocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Although Ang II had prominent effects on SERCA2 in ventricular myocytes, it did not alter SERCA2 gene expression and protein levels in atrial myocytes. We provide a model for further investigation of the regulation of SERCA2 gene expression in atrial myocytes. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - August 26, 2009 Category: Biomedical Science Authors: Wu, C.-K., Tseng, C.-D., Huang, Y.-T., Hsieh, C.-S., Tsai, W.-S., Lin, J.-L., Chiang, F.-T., Tsai, C.-T. Tags: Article Source Type: journals

Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. No association of the ACE gene insertion/deletion polymorphism with longevity was observed in our Han Chinese population. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 5, 2009 Category: Biomedical Science Authors: Yang, J.-K., Gong, Y.-Y., Liang Xie, , Lian, S.-G., Juan Yang, , Xu, L.-Y., Gao, S.-J., Zhang, Y.-P. Tags: Article Source Type: journals

The insertion/deletion polymorphism of the angiotensin-converting enzyme gene is associated with progression, but not development, of albuminuria in Iranian patients with type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. In Iranian patients with type 2 diabetes, the D allele is associated with progression, but not development, of albuminuria. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 5, 2009 Category: Biomedical Science Authors: Nikzamir, A., Esteghamati, A., Feghhi, M., Nakhjavani, M., Rashidi, A., Javad Zavar Reza, Tags: Article Source Type: journals

Renin-angiotensin system polymorphisms and the association between use of angiotensin II receptor blockers or angiotensin-converting enzyme inhibitors and the risk of diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Angiotensin II receptor blockers increase the occurrence of diabetes in homozygous 1166C carriers of angiotensin II type 1 receptor, but not in 1166A carriers. ACE inhibitors at doses ≥ 1 defined daily dose/day increase the risk of diabetes among homozygous ACE GG carriers, but not in 4656C carriers. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 5, 2009 Category: Biomedical Science Authors: Bozkurt, O., de Boer, A., Grobbee, D. E, Kroon, A. A, Schiffers, P., de Leeuw, P., Klungel, O. H Tags: Article Source Type: journals

Angiotensin-converting enzyme gene insertion/deletion polymorphism in Egyptian patients with myocardial infarctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. The angiotensin-converting enzyme gene I/D polymorphism is probably a risk factor for ischaemic heart disease among Egyptian cases, particularly if integrated with other environmental and genetic risk factors. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 5, 2009 Category: Biomedical Science Authors: Settin, A., ElBaz, R., Abbas, A., Abd-Al-Samad, A., Noaman, A. Tags: Article Source Type: journals

First-in-man use of polymer-free valsartan-eluting stents in small coronary vessels: a comparison to polymer-free rapamycin (2%)-eluting stentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. If polymer-free YUKON Choice stents are used in small vessels, valsartan-eluting stents show an identical efficacy as rapamycin-loaded stents. In patients with rapamycin-eluting YUKON Choice stents it seems that the efficacy can be increased by oral valsartan administration. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 5, 2009 Category: Biomedical Science Authors: Peters, S., Behnisch, B., Heilmann, T., Richter, C. Tags: Article Source Type: journals

Perindopril decreases P wave dispersion in patients with stage 1 hypertensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. Perindopril treatment significantly reduced PWD in hypertensive patients. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 5, 2009 Category: Biomedical Science Authors: Ozben, B., Sumerkan, M., Tanrikulu, A. M., Papila-Topal, N., Fak, A. S., Toprak, A. Tags: Article Source Type: journals

Effects of enalapril or nifedipine on muscle strength or functional capacity in elderly subjects. A double blind trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. In this group of elderly subjects, enalapril was not superior to nifedipine with regard to the age-related decline of muscle performance. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 5, 2009 Category: Biomedical Science Authors: Bunout, D., Barrera, G., de la Maza, M. P., Leiva, L., Backhouse, C., Hirsch, S. Tags: Article Source Type: journals

Managing cardiovascular and renal risk: the potential of direct renin inhibitionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aliskiren is the first direct renin inhibitor for the treatment of hypertension. Clinical experience from studies in over 14,000 patients has shown that aliskiren, alone or in combination with other antihypertensive therapies, provides effective blood pressure lowering with a good safety and tolerability profile.The ultimate aim of antihypertensive therapy, however, is to reduce the risk of adverse cardiovascular and renal outcomes.The effect of aliskiren on surrogate markers of organ damage and clinical outcomes is being assessed in the ongoing ASPIRE HIGHER programme, the largest clinical trials programme in the cardio-r...
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 5, 2009 Category: Biomedical Science Authors: Sever, P. S, Gradman, A. H, Azizi, M. Tags: Article Source Type: journals

Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions.The ID genotype was less frequently associated with the disease than were the DD or II; that is, women with the ID genotype were 3.1 times less likely to develop breast cancer than those with the other genotypes.The ID genotype might be protective against breast cancer and the ACE (I/D) polymorphism a possible target for developing genetic markers for breast cancer. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 13, 2009 Category: Biomedical Science Authors: Alves Correa, S. A., Ribeiro de Noronha, S. M., Nogueira-de-Souza, N. C., Valleta de Carvalho, C., Massad Costa, A. M., Juvenal Linhares, J., Vieira Gomes, M. T., Guerreiro da Silva, I. D. C. Tags: Article Source Type: journals

Impact of renin-angiotensin system polymorphisms on renal haemodynamic responsiveness to acute angiotensin-converting enzyme inhibition in type 2 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Our data indicate that the heterogeneity of patients' response to ACE inhibition is, at least partly, genetically determined, and the genetic polymorphisms in RAS might predict the acute responsiveness to ACE inhibitors. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 13, 2009 Category: Biomedical Science Authors: Volkan-Salanci, B., Dagdelen, S., Alikasifoglu, M., Erbas, T., Hayran, M., Erbas, B. Tags: Article Source Type: journals

Association of the insertion/deletion polymorphism of the angiotensin-converting enzyme gene with type 2 diabetes in two ethnic groups of Jerba Island in TunisiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions.The current investigation provides new evidence regarding the role of the ACE I/D polymorphism in the pathogenesis of type 2 diabetes in Jerbian populations. Furthermore, it underlines the importance of ethnicity, which should be considered in all studies aiming to test the genetic effects on the susceptibility to type 2 diabetes. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 13, 2009 Category: Biomedical Science Authors: Baroudi, T., Bouhaha, R., Moran-Moguel, C., Sanchez-Corona, J., Ben Maiz, H., Kammoun Abid, H., Benammar-Elgaaied, A. Tags: Article Source Type: journals

Meta-analysis of association of ACE2 G8790A polymorphism with Chinese Han essential hypertensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. The meta-analysis suggests that ACE2 G8790A polymorphism may not be a genetic risk factor for essential hypertension in a Chinese Han population. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 13, 2009 Category: Biomedical Science Authors: Zhou, J.-B., Yang, J.-K. Tags: Article Source Type: journals

Superoxide dismutase and catalase anti-oxidant activity in leucocyte lysates from hypertensive patients: effects of eprosartan treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. This result could be interpreted as a cell defence mechanism against the greater oxidative stress that exists in these patients.This hypothesis is consistent with the facts reported previously by our group in which a reduction in oxidative stress was found after two months of treatment with eprosartan. 1 Upon reducing this stress, less anti-oxidative activity would be necessary, just as was observed in the present study after two months of treatment with eprosartan. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 13, 2009 Category: Biomedical Science Authors: Labios, M., Martinez, M., Gabriel, F., Guiral, V., Dasi, F., Beltran, B., Munoz, A. Tags: Article Source Type: journals

Local renin-angiotensin system regulates left ventricular hypertrophy induced by swimming training independent of circulating renin: a pharmacological studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions.These data provide evidence that the physiological LVH induced by swimming training is regulated by local RAS independent from the systemic, because the hypertrophic response was maintained even when PRA was inhibited by chronic salt loading. However, other systems can contribute to this process. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 13, 2009 Category: Biomedical Science Authors: Oliveira, E. M., Sasaki, M. S., Cerencio, M., Barauna, V. G., Krieger, J. E. Tags: Article Source Type: journals

Role of oxidative stress in the natriuresis induced by central administration of angiotensin IIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion.This study demonstrates that increases of urinary sodium and potassium excretion elicited by central administration of Ang II are mediated by NAD(P)H oxidase- dependent production of superoxide and protein kinase C activation in conscious hydrated rats. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 13, 2009 Category: Biomedical Science Authors: Israel, A., Arzola, J., De Jesus, S., Varela, M. Tags: Article Source Type: journals

Review: Renal protection by inhibition of the renin-angiotensin-aldosterone systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Renin-angiotensin-aldosterone system (RAAS) inhibition exerts a renoprotective effect independent of blood pressure reduction. Many studies using an end-point of proteinuria compared the effects of angiotensin-converting enzyme inhibitor (ACE-I) or angiotensin receptor blocker (ARB) monotherapy with combination ACE-I/ARB therapy. Despite methodological limitations, most studies suggest that combination therapy provides a greater antiproteinuric effect than monotherapy, perhaps because of more prolonged and complete RAAS inhibition. COOPERATE and ONTARGET used more robust end-points to study renoprotective effects. In COOPE...
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - March 13, 2009 Category: Biomedical Science Authors: Berl, T. Tags: Article Source Type: journals

Questions & Answers -- Understanding the Renin SystemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - January 6, 2009 Category: Biomedical Science Tags: Article Source Type: journals

Renin-angiotensin system-related highlights from the High Blood Pressure Research Conference annual meetingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The High Blood Pressure Research Conference of the American Heart Association is a theoretical meeting for hypertension researchers who direct their attention to hypertension-related basic disease mechanisms. The items that I have selected for this brief review are molecular intracellular receptor function, novel angiotensin (Ang)-related pathways, including Ang-(1-7), the Mas receptor, and angiotensin-converting enzyme 2, oxidative stress, immunity, the (pro)renin receptor, and until now unappreciated signalling pathways, such as the tonicity element binding protein. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - January 6, 2009 Category: Biomedical Science Authors: Luft, F. C Tags: Article Source Type: journals

Chronic angiotensin-converting enzyme inhibition up-regulates mouse kidney growth arrest specific-6 protein and the AXL subfamily of receptor tyrosine kinasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. These findings suggest that GAS-6 may not be a final common pathway for nitric oxide synthase inhibition-induced renal disease. Renal tubular GAS-6 expression following captopril treatment was unexpected and could be beneficial in preventing tubular atrophy following the onset of persistent systemic hypertension. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - January 6, 2009 Category: Biomedical Science Authors: Pei Chia Eng, , Chua, W. C.-N., Suk Peng Chew, V., Wong, P. T. H., Jian Lin Yin, , Hambly, B., McLachlan, C. S. Tags: Article Source Type: journals

The angiotensin AT4 receptor subtype as a target for the treatment of memory dysfunction associated with Alzheimer's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Over recent years antihypertensive drugs, particularly angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs), have been reported to have beneficial effects upon cognitive impairment. Such findings suggest that pharmacological manipulation of angiotensin ligands may be of clinical importance in slowing or halting the cognitive deterioration seen in vascular dementia and Alzheimer's disease.The mechanism(s) underlying these improvements in cognitive function remains unclear; however, important leads are emerging. The angiotensin AT 4 receptor subtype, discovered by our laboratory in 1992, in...
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - January 6, 2009 Category: Biomedical Science Authors: Wright, J. W, Harding, J. W Tags: Article Source Type: journals

The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pillEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. Increased AP-P may result in increased breakdown of bradykinin.These data suggest that progesterone-induced increases in AP-P may contribute to the development of OCP-induced hypertension in susceptible Women. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - January 6, 2009 Category: Biomedical Science Authors: La Corte, A. L C., Carter, A. M, Turner, A. J, Grant, P. J, Hooper, N. M Tags: Article Source Type: journals

Angiotensin-converting enzyme gene polymorphism in arrhythmogenic right ventricular dysplasia: is DD genotype helpful in predicting syncope risk?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. High prevalence of DD genotype in ARVD patients with syncope suggests that ACE I/D polymorphism might be useful in identifying high-risk patients for syncope. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - January 6, 2009 Category: Biomedical Science Authors: Ozben, B., Altun, I., Sabri Hancer, V., Bilge, A. K., Tanrikulu, A. M., Diz-Kucukkaya, R., Fak, A. S., Yilmaz, E., Adalet, K. Tags: Article Source Type: journals

Association of insertion/deletion polymorphism of angiotensin-converting enzyme gene with essential hypertension and type 2 diabetes mellitus in Malaysian subjectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. The D allele of the ACE gene is associated with essential HTN and T2DM in Malaysian subjects. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - January 6, 2009 Category: Biomedical Science Authors: Ramachandran, V., Ismail, P., Stanslas, J., Shamsudin, N., Moin, S., Mohd Jas, R. Tags: Article Source Type: journals

Association of renin-angiotensin system and natriuretic peptide receptor A gene polymorphisms with hypertension in a Hellenic populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. In the present study conducted in a homogeneous Hellenic population, no associations betweenAGT,ACE, and NPRA gene polymorphisms and hypertension were found. The presence of a significant negative association between the LL polymorphism of the renin gene and hypertension requires further confirmation. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - January 6, 2009 Category: Biomedical Science Authors: Tsezou, A., Karayannis, G., Giannatou, E., Papanikolaou, V., Triposkiadis, F. Tags: Article Source Type: journals

Up- and down-regulation of angiotensin II AT1-A and AT1-B receptors in afferent and efferent rat kidney arteriolesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. These results indicate that the AT1 receptor sub-types are regulated independently in the SMCs of the normal kidney arterioles. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - January 6, 2009 Category: Biomedical Science Authors: Razga, Z., Nyengaard, J. R. Tags: Article Source Type: journals

Experimental models for nephropathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephropathy is a leading cause of morbidity and mortality and its prevalence is continuously increasing in industrialised nations. Nephropathy is characterised to varying degrees by nodular glomerulosclerosis, glomerular basement membrane thickness and mesangial expansion, leading to a decline in glomerular filtration rate, persistent elevated albuminuria, elevated arterial blood pressure and fluid retention. Hyperglycaemia, hyperlipidaemia and hypertension are considered to be the major risk factors implicated in the progression of nephropathy.Various signalling systems, such as vasoconstrictor peptides, inflammatory medi...
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - January 6, 2009 Category: Biomedical Science Authors: Balakumar, P., Vishal Arvind Chakkarwar, , Kumar, V., Jain, A., Reddy, J., Singh, M. Tags: Article Source Type: journals

Young Investigator Award Winner 2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - October 20, 2008 Category: Biomedical Science Tags: Article Source Type: journals

Which strategy in inhibition of the renin-angiotensin system is the most efficient for heart failure?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - October 20, 2008 Category: Biomedical Science Authors: Ogihara, T., Rakugi, H. Tags: Article Source Type: journals

Prorenin and the (pro)renin receptor: binding kinetics, signalling and interaction with aliskirenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - October 20, 2008 Category: Biomedical Science Authors: Batenburg, W. W, Danser, A. J. Tags: Article Source Type: journals

Role of renin in heart failure and therapeutic potential of direct renin inhibitionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - October 20, 2008 Category: Biomedical Science Authors: Krum, H. Tags: Article Source Type: journals

Can aliskiren reduce the incidence of cough caused by ramipril?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - October 20, 2008 Category: Biomedical Science Authors: Saijonmaa, O., Fyhrquist, F. Tags: Article Source Type: journals

Effects of the direct renin inhibitor aliskiren and atenolol alone or in combination in patients with hypertension1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Direct renin inhibition with aliskiren may be an appropriate substitute for beta-blocker treatment in patients with uncomplicated hypertension. Aliskiren also represents an attractive option for dual therapy with atenolol to improve systolic BP/pulse pressure reductions and BP control with maintained tolerability compared with atenolol alone. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - October 20, 2008 Category: Biomedical Science Authors: Dietz, R., Dechend, R., Yu, C.-M., Bheda, M., Ford, J., Prescott, M. F., Keefe, D. L. Tags: Article Source Type: journals

Early expression of monocyte chemoattractant protein-1 correlates with the onset of isoproterenol-induced cardiac fibrosis in rats with distinct angiotensin-converting enzyme polymorphismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. We conclude that the greater cardiac fibrosis in Brown Norway rats treated with isoproterenol correlates with the early and higher expression of proinflammatory factors. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - October 20, 2008 Category: Biomedical Science Authors: Copaja Soto, M., Valenzuela, R., Saldana, A., Paz Ocaranza, M., Jalil, J. E., Vio, C., Lijnen, P., Ordenes, G. E., Vivar Sanchez, R., Lavandero, S., Diaz-Araya, G. Tags: Article Source Type: journals

Hypertension-induced renal fibrosis and spironolactone response vary by rat strain and mineralocorticoid receptor gene expressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. Hypertension-induced renal fibrosis was greatest in rats with the highest MR gene expression. Spironolactone abolished inter-strain differences in fibrosis. Our data suggest that MR genotype may influence aldosterone-induced renal damage, and consequently, renal response to aldosterone antagonism. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - October 20, 2008 Category: Biomedical Science Authors: Cavallari, L. H., Fashingbauer, L. A., Camp, J. R., King, S. T., Geenen, D. L. Tags: Article Source Type: journals

Blockade of calcineurin reverses cardiac hypertrophy and induces the down-regulation of JNK mRNA expression in renovascular hypertensive ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. There is cross-talk between the calcineurin and JNK pathway in controlling renovascular hypertension-induced cardiac hypertrophy. Inhibition of the calcineurin and JNK pathways may be the basis of reversal of cardiac hypertrophy by calcineurin blockers. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - October 20, 2008 Category: Biomedical Science Authors: Hongzhuan Sheng, , Jianhua Zhu, , Xiaohui Wu, , Jinan Zhang, Tags: Article Source Type: journals

Vasopressin and angiotensin receptors of the medial septal area in the control of mean arterial pressure induced by vasopressinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. These results indicate there is a synergism between the V1a- and V2-AVP and AT1and AT2-Ang II receptors in the MSA in the regulation of MAP. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - October 20, 2008 Category: Biomedical Science Authors: Pavan de Arruda Camargo, G. M., Abrao Saad, W., de Arruda Camargo, L. A. Tags: Article Source Type: journals

Inhibition of the renin-angiotensin system: effects on tachycardia-induced early electrical remodelling in rabbit atriumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. In summary, EPT has several effects on ion channels in rabbit atrium: 1) EPT increases ICa,L current density, but cannot prevent its downregulation due to RAP; 2) EPT has no influence on Ito current density, but can prevent its downregulation due to RAP. Although changes of single ion channels must be interpreted in context of the complex atrial electrophysiology as a whole, our results provide a possible explanation of the in vivo observation that angiotensin-converting enzyme inhibition is mainly beneficial on the early electrical remodelling due to the atrial fibrillation-equivalent RAP. (Source: Journal of...
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - October 20, 2008 Category: Biomedical Science Authors: Laszlo, R., Eick, C., Rueb, N., Weretka, S., Weig, H.-J., Schreieck, J., Bosch, R. F Tags: Article Source Type: journals

Renin Academy in Focus: Renin Academy presence at major congressesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 1, 2008 Category: Biomedical Science Authors: Ruilope, L. M Tags: Article Source Type: journals

Spotlight on Renin: The Renin Academy Summit: advancing the understanding of renin scienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 1, 2008 Category: Biomedical Science Authors: Danser, A. J., Nguyen, G. Tags: Article Source Type: journals

Intracellular and extracellular renin have opposite effects on the regulation of heart cell volume. Implications for myocardial ischaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Intracellular and extracellular renin plus Ao have opposite effects on sodium pump and cell volume regulation in the failing heart. Both effects of renin plus Ao are dependent upon the formation of Ang II. Since intracellular Ang II counteracted the cell swelling induced by hypotonic solution, it is reasonable to think that the activation of the intracrine renin-angiotensin system might play a protective role during myocardial ischaemia by reducing cell volume. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 1, 2008 Category: Biomedical Science Authors: De Mello, W. C Tags: Article Source Type: journals

Effect of losartan on exercise tolerance and echocardiographic parameters in patients with mitral regurgitationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. We conclude that the angiotensin II receptor antagonist losartan improves exercise tolerance and echocardiographic parameters in patients with moderate MR. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 1, 2008 Category: Biomedical Science Authors: Sekuri, C., Utuk, O., Bayturan, O., Bilge, A., Kurhan, Z., Tavli, T. Tags: Article Source Type: journals

Primary hyperaldosteronism due to adrenal microadenoma: a curable cause of refractory hypertensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. The robotic assay of renin mass permits rapid detection of patients in whom plasma renin is suppressed below the normal range. A suppressed plasma renin indicates abnormal Na+-retention, and — when not overcome by drugs such as angiotensin-converting enzyme-inhibitors or angiotensin receptor blockers — may be the only clue to a curable adrenal adenoma.AVS is required to demonstrate lateralisation of aldosterone secretion, justifying adrenalectomy. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 1, 2008 Category: Biomedical Science Authors: Myint, K. S., Watts, M., Appleton, D. S, Lomas, D. J, Jamieson, N., Taylor, K. P, Coghill, S., Brown, M. J Tags: Article Source Type: journals