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This page shows you the latest news and research items in this category.

Should high‐risk adolescents have Papanicolaou tests?
CONCLUSIONSThe study findings indicated that current American College of Obstetricians and Gynecologists guidelines to begin Pap testing at age 21 years are appropriate for the majority of adolescents, because the rate of HSIL is very low, and the risk for invasive carcinoma is minimal. Although higher parity was associated with a significantly increased grade of CIN, the conclusions are questionable because of the significant amount of missing demographic data points. That being said, this study should lead to other similar studies to determine any association of higher grade CIN with adolescent sexual and obstetric histo...
Source: Cancer Cytopathology - February 28, 2013 Category: Pathology Authors: Ly T. Ma, Gerald A. Campbell, Gwyn Richardson, Vicki J. Schnadig Tags: Original Article Source Type: research

Risk of cesarean delivery after loop electrosurgical excision procedure.
CONCLUSION: : Loop electrosurgical excision procedure does not affect mode of delivery in the subsequent pregnancy. LEVEL OF EVIDENCE: : II. PMID: 23262926 [PubMed - in process] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - January 1, 2013 Category: OBGYN Authors: Frey HA, Stout MJ, Odibo AO, Stamilio DM, Cahill AG, Roehl KA, Macones GA Tags: Obstet Gynecol Source Type: research

Loop electrosurgical excision procedure as a life event that impacts on postmenopausal women
ConclusionLimited to our sample, the psychological impact of LEEP seems to be greater in postmenopausal than in premenopausal women. We speculate that LEEP could cause failure of psychological domains already weakened by menopause. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - December 21, 2012 Category: OBGYN Authors: Luca Giannella, Kabala Mfuta, Ruggiero Lamantea, Fausto Boselli, Barbara Torrini, Sonia Prandi Tags: Original Article Source Type: research

Pilot study of patient and caregiver out-of-pocket costs of allogeneic hematopoietic cell transplantation
sen, E Murphy & K Pederson (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - December 10, 2012 Category: Hematology Authors: N S MajhailJ D RizzoT HahnS J LeeP L McCarthyM AmmiE DenzenR DrexlerS FleschH JamesN OmondiT L PedersenE MurphyK Pederson Tags: allogeneic hematopoietic cell transplantation costs financial impact out-of-pocket expenses Source Type: research

Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ
Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ Oncogene advance online publication, November 26 2012. doi:10.1038/onc.2012.517 Authors: S Jin, A P Mutvei, I V Chivukula, E R Andersson, D Ramsköld, R Sandberg, K L Lee, P Kronqvist, V Mamaeva, P Östling, J-P Mpindi, O Kallioniemi, I Screpanti, L Poellinger, C Sahlgren & U Lendahl (Source: Oncogene)
Source: Oncogene - November 26, 2012 Category: Cancer & Oncology Authors: S JinA P MutveiI V ChivukulaE R AnderssonD RamsköldR SandbergK L LeeP KronqvistV MamaevaP ÖstlingJ-P MpindiO KallioniemiI ScrepantiL PoellingerC SahlgrenU Lendahl Tags: cytokine inflammation tumor stroma estrogen receptor breast cancer BCL Source Type: research

A modified Latent Class Model assessment of human papillomavirus-based screening tests for cervical lesions in women with atypical glandular cells: a Gynecologic Oncology Group study
Conclusions Women with negative HC2 H-HPV can safely forego invasive treatment (i.e., cone or LEEP biopsy, hysterectomy) in favor of observational follow-up. Additional biomarkers must be found for use in combination with HC2 H-HPV to reduce false-positive rates. This novel application of a modified LCM exemplifies methods for potential use in future cancer screening studies when gold standard diagnoses are not available. Content Type Journal ArticleCategory Original paperPages 1-9DOI 10.1007/s10552-012-0081-0Authors Randy L. Carter, GOG Statistical and Data Center, Roswell Park Cancer Institute, B...
Source: Cancer Causes and Control - October 16, 2012 Category: Cancer & Oncology Tags: Cancer Causes and Control Source Type: research

Antibiotic prophylaxis for selected gynecologic surgeries
Conclusion: Antibiotic prophylaxis may be beneficial in first-trimester suction curettage and laparotomy. No advantage was found for loop electrosurgical excision, hysteroscopy, or laparoscopic gynecologic surgery. Newer procedures and vaginal surgery lack research and merit study. (Source: International Journal of Gynaecology and Obstetrics)
Source: International Journal of Gynaecology and Obstetrics - October 8, 2012 Category: OBGYN Authors: Michelle Y. Morrill, Megan O. Schimpf, Husam Abed, Cassandra Carberry, Rebecca U. Margulies, Amanda B. White, Lior Lowenstein, Renée M. Ward, Ethan M. Balk, Katrin Uhlig, Vivian W. Sung, for the Society of Gynecologic Surgeons Systematic Review Group Tags: Review articles Source Type: research

Negative loop electrosurgical cone biopsy finding following a biopsy diagnosis of high-grade squamous intraepithelial lesion: frequency and clinical significance.
Conclusions.-Twenty-four percent of patients with HSIL on biopsy had negative findings or LSIL on LEEP. There is no statistical difference in development of HSIL after LEEP for those with positive biopsy and positive LEEP results (13%) versus positive biopsy and negative LEEP results (10%). The occurrence of a negative LEEP finding following a positive biopsy finding was frequent (24%) and does not portend a different clinical follow-up from a positive biopsy and positive LEEP result. PMID: 23020732 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - October 1, 2012 Category: Laboratory Medicine Authors: Witt BL, Factor RE, Jarboe EA, Layfield LJ Tags: Arch Pathol Lab Med Source Type: research

Detection of Residual/Recurrent Cervical Disease after Successful LEEP Conization: the Possible Role of mRNA-HPV Test.
Conclusion: The inclusion of mRNA test within the current protocol of follow-up would efficiently and earlier predict the risk of residual/recurrent cervical abnormalities after conisation. This molecular strategy would also reduce overtreatment, particularly in patients above 30 years of age. PMID: 23016778 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 24, 2012 Category: Drugs & Pharmacology Authors: Roberta Z, Maria IM, Andrea T, Chiara D, Maria GD, Serena C, Sandra R Tags: Curr Pharm Des Source Type: research

Method to map individual electromagnetic field components inside a photonic crystal
We present a method to map the absolute electromagnetic field strength inside photonic crystals. We apply the method to map the dominant electric field component Ez of a two-dimensional photonic crystal slab at microwave frequencies. The slab is placed between two mirrors to select Bloch standing ... (Source: Optics Express)
Source: Optics Express - September 21, 2012 Category: Physics Authors: T. DenisB. ReijndersJ. H. H. LeeP. J. M. van der SlotW. L. VosK.-J. Boller Source Type: research

Median nerve ultrasound in diabetic peripheral neuropathy with and without carpal tunnel syndrome
Conclusions:In this pilot study, NCS may be superior to ultrasound for identification of superimposed CTS in diabetic PN patients, but larger numbers are needed for confirmation. (Source: Muscle and Nerve)
Source: Muscle and Nerve - September 15, 2012 Category: Internal Medicine Authors: Anhar Hassan, Andrea N Leep Hunderfund, James Watson, Andrea J Boon, Eric J Sorenson Tags: Short Report Source Type: research

Does LEEP Invariably Increase the Risk for Preterm Birth?Does LEEP Invariably Increase the Risk for Preterm Birth?
Previous studies suggest that treatment for cervical intraepithelial neoplasia raises risk for subsequent preterm delivery. Medscape Ob/Gyn (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 14, 2012 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Commentary Source Type: news

Predictive value of negative cone margin status for risk of residual disease among women with cervical adenocarcinoma in situ
Abstract: Objective: To determine the value of negative cone margins in predicting residual disease in women with adenocarcinoma in situ (ACIS).Methods: Data were retrospectively analyzed from 60 women with ACIS who underwent conization at Chiang Mai University Hospital between March, 1998, and December, 2010. Negative margin status was defined as absence of neoplastic epithelium at all margins, coupled with presence of normal cervical epithelium. The association between the incidence of residual lesions and cone margin status was analyzed via χ2 or Fisher exact test.Results: When adjusted for age and completeness of visu...
Source: International Journal of Gynaecology and Obstetrics - August 31, 2012 Category: OBGYN Authors: Chumnan Kietpeerakool, Surapan Khunamornpong, Jatupol Srisomboon, Ajchara Kasunan, Narisa Sribanditmongkol, Sumalee Siriaungkul Tags: Clinical articles Source Type: research

A non-oncogenic HPV 16 E6/E7 vaccine enhances treatment of HPV expressing tumors
A non-oncogenic HPV 16 E6/E7 vaccine enhances treatment of HPV expressing tumors Cancer Gene Therapy advance online publication, August 24 2012. doi:10.1038/cgt.2012.55 Authors: B G Wieking, D W Vermeer, W C Spanos, K M Lee, P Vermeer, W T Lee, Y Xu, E S Gabitzsch, S Balcaitis, J P Balint, F R Jones & J H Lee (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - August 24, 2012 Category: Cancer & Oncology Authors: B G WiekingD W VermeerW C SpanosK M LeeP VermeerW T LeeY XuE S GabitzschS BalcaitisJ P BalintF R JonesJ H Lee Tags: adenovirus E6 E7 head and neck cancer HPV immunotherapy Source Type: research

The detection of hTERC amplification using fluorescence in situ hybridization in the diagnosis and prognosis of cervical intraepithelial neoplasia: a case control study
Background: Currently the routine non-invasive screening methods for cervical intraepithelial neoplasia (CIN) and cervical cancer are Thinprep cytology test (TCT) and human papillomavirus testing. However, both methods are limited by the high false positive and false negative rates and lack of association with patients' prognosis, especially for the early detection of pro-malignant CIN. The aim of the study was to investigate the role of genomic amplification of human telomerase gene (hTERC) in the diagnosis and prognosis of CIN. Methods: The study group consisted of specimens of exfoliated cervical cells from 151 patients...
Source: World Journal of Surgical Oncology - August 21, 2012 Category: Cancer & Oncology Authors: Geping YinJuan LiTongyu ZhuXiaoli Zhao Source Type: research

Assessment of cervical intraepithelial neoplasia (CIN) with colposcopic biopsy and efficacy of loop electrosurgical excision procedure (LEEP)
Conclusions Assessment of cervical lesions with colposcopic biopsy is an accurate method (concordance with cone histology 85.8 %). Surgical treatment of high grade CIN with LEEP is a safe procedure with low recurrence rates, resulting in a clearance of cervical HPV infection in the majority of cases. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-6DOI 10.1007/s00404-012-2493-1Authors Nina Duesing, Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, GermanyJoerg Schwarz, Department of Gynecology and G...
Source: Archives of Gynecology and Obstetrics - August 3, 2012 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: research

Screening for and management of high‐grade cervical intraepithelial neoplasia in Bangladesh: A cross‐sectional study comparing two protocols
Conclusion: ‘See and treat’ protocol is a well‐accepted, feasible and useful option for management of high‐grade CIN in Bangladesh. It reduces the number of visits to the clinic and failure to receive treatment. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - August 1, 2012 Category: OBGYN Authors: Ashrafun Nessa, Mohammad Harun Ur Rashid, Noor E‐Ferdous, Afroza Chowdhury Source Type: research

Cyclic AMP regulation of protein lysine acetylation in Mycobacterium tuberculosis
p; Tom Alber (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - July 8, 2012 Category: Molecular Biology Authors: Ho Jun LeeP Therese LangSarah M FortuneChristopher M SassettiTom Alber Tags: Article Source Type: research

Risk factors for cervical intraepithelial neoplasia recurrence after conization: a 10-year study
Conclusions: Our study demonstrated that the surgical margin status represents the most important predictor for CIN recurrence after conization. After excisional therapy, close follow-up is mandatory for the early detection of recurrent disease. The identification of risk factors for recurrence may guide clinical decision-making on expectant management versus re-intervention. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - July 2, 2012 Category: OBGYN Authors: Maurizio Serati, Gabriele Siesto, Simona Carollo, Giorgio Formenti, Cristina Riva, Antonella Cromi, Fabio Ghezzi Tags: Gynecology and Gynecological Oncology Source Type: research

Efficacy of Fibrin Sealant in Reducing Hemorrhage after a Loop Electrosurgical Excision Procedure
(Source: Gynecologic and Obstetric Investigation)
Source: Gynecologic and Obstetric Investigation - June 25, 2012 Category: OBGYN Source Type: research

World Health Organization Guidelines: Use of cryotherapy for cervical intraepithelial neoplasia
Conclusion: The present document summarizes new evidence-based WHO recommendations about the use of cryotherapy in women with histologically confirmed CIN for low-, middle-, and high-income countries. (Source: International Journal of Gynaecology and Obstetrics)
Source: International Journal of Gynaecology and Obstetrics - June 25, 2012 Category: OBGYN Authors: Nancy Santesso, Holger Schünemann, Paul Blumenthal, Hugo De Vuyst, Julia Gage, Francisco Garcia, Jose Jeronimo, Ricky Lu, Silvana Luciani, Swee C. Quek, Tahany Awad, Nathalie Broutet, for the World health Organization Steering Committee for the Recommend Tags: Special communication Source Type: research

Successful conservative management of a large iatrogenic vesicovaginal fistula after loop electrosurgical excision procedure
A 40-year-old G3P3 woman with grade 3 cervical intraepithelial neoplasia underwent loop electrosurgical excision procedure complicated by a large vesicovaginal fistula. She was initially managed with an indwelling Foley catheter to allow for fistula maturation. During planned surgical repair it was discovered that the fistula had closed spontaneously. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - June 14, 2012 Category: OBGYN Authors: Trevor T. Wild, Catherine S. Bradley, Bradley A. Erickson Tags: Case Reports Source Type: research

A placebo-controlled randomized HPV16 synthetic long-peptide vaccination study in women with high-grade cervical squamous intraepithelial lesions
Abstract The aim of this study was to investigate the capacity of an HPV16 E6/E7 synthetic overlapping long-peptide vaccine to stimulate the HPV16-specific T-cell response, to enhance the infiltration of HPV16-specific type 1 T cells into the lesions of patients with HPV16+ high-grade cervical squamous intraepithelial lesion (HSIL) and HPV clearance. This was a placebo-controlled randomized phase II study in patients with HPV16-positive HSIL. HPV16-specific T-cell responses were determined pre- and post-vaccination by ELISPOT, proliferation assay and cytokine assays in PBMC and HSIL-infiltrating lymphocytes,...
Source: Cancer Immunology, Immunotherapy - June 9, 2012 Category: Cancer & Oncology Tags: Cancer Immunology, Immunotherapy Source Type: research

Review: excisional, and perhaps ablative treatments for precancerous cervical changes increase the risk for preterm birth
Context Cervical intraepithelial neoplasia (CIN) is a common complication in women of reproductive age. Treatment options include excisional treatments, such as cold knife conisation, loop electrosurgical excision procedure, large loop excision of the transformation zone (LLETZ) and laser conisation; and ablative treatments, including cryotherapy, laser ablation, cold coagulation and diathermy. These treatments may have an impact on subsequent pregnancy outcomes. The meta-analysis by Bruinsma and Quinn evaluates the effect of the type of comparison group on the association between treatment for CIN and subsequent preterm b...
Source: Evidence-Based Medicine - June 8, 2012 Category: Internal Medicine Authors: Crane, J. Tags: Rehabilitation medicine, Epidemiologic studies, Pregnancy, Radiology, Vulvovaginal disorders, Sports and exercise medicine, Surgical diagnostic tests, Clinical diagnostic tests Therapeutics Source Type: research

Adherence to conservative management recommendations for abnormal pap test results in adolescents.
CONCLUSION: : Health care providers quickly adopted new conservative management guidelines for low-income, minority adolescents, which may reduce preterm deliveries in these high-risk populations. LEVEL OF EVIDENCE: : II. PMID: 22617580 [PubMed - in process] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - June 1, 2012 Category: OBGYN Authors: Perkins RB, Jorgensen JR, McCoy ME, Bak SM, Battaglia TA, Freund KM Tags: Obstet Gynecol Source Type: research

Personality influences quality-of-life assessments in adult patients after allogeneic hematopoietic SCT: results from a joint evaluation of the prospective German Multicenter Validation Trial and the Fred Hutchinson Cancer Research Center
nd, E Holler & D Wolff (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - May 21, 2012 Category: Hematology Authors: P Y HerzbergS J LeeP HeussnerF H A MummI HilgendorfS von HarsdorfP HemmatiK RiegerH T GreinixM FreundE HollerD Wolff Tags: allogeneic hematopoietic SCT personality GVHD quality of life physical functioning Source Type: research

The “see and treat” strategy for identifying cytologic high-grade precancerous cervical lesions among low-income Brazilian women
Conclusion: For cytologic HSIL, the benefits of the strategy of “see and treat” by LEEP outweighed the risk of overtreatment. Patients with both positive and negative margins on LEEP should be followed carefully. (Source: International Journal of Gynaecology and Obstetrics)
Source: International Journal of Gynaecology and Obstetrics - May 18, 2012 Category: OBGYN Authors: Paula R.B. Nogara, Luís A.R. Manfroni, Mariana C. da Silva, Marcia E.L. Consolaro Tags: Clinical articles Source Type: research

Value‐based medicine analysis on loop electrosurgical excision procedure and CO2 laser vaporization for the treatment of cervical intraepithelial neoplasia 2
Conclusion: Both LEEP and CO2 laser vaporization are effective and reliable treatments for CIN2, whereas cervical tissue can be obtained for histology by LEEP. Preoperative evaluation and postoperative follow‐up are important. Gynecologists should pay attention to QOL of patients with CIN. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - May 8, 2012 Category: OBGYN Authors: Lu‐lu Sun, Dong‐yan Cao, Jia‐xin Yang, Mei‐lu Bian, Li‐hui Wei, Keng Shen Source Type: research

Single visit approach for management of cervical intraepithelial neoplasia by visual inspection & loop electrosurgical excision procedure.
This study was aimed to evaluate a single visit approach (SVA) for the management of cervical intraepithelial neoplasia (CIN) using visual inspection with acetic acid (VIA) and Lugol's iodine (VILI) along with loop electrosurgical excision procedure (LEEP) in women attending Gynaecology OPD in a tertiary care hospital in north India. Methods: In this hospital-based study, 450 women receiving opportunistic screening by conventional Pap cytology were also screened by VIA and VILI. VIA/VILI positive cases underwent same-day colposcopy and biopsy of all lesions. If the modified Reid score was >3, the patient underwent LEEP ...
Source: Indian J Med Res - May 1, 2012 Category: Research Authors: Singla S, Mathur S, Kriplani A, Agarwal N, Garg P, Bhatla N Tags: Indian J Med Res Source Type: research

Endocervical glandular involvement, positive endocervical surgical margin and multicentricity are more often associated with high‐grade than low‐grade squamous intraepithelial lesion
Conclusion: The current study showed that EGI, positive ESM and multicentricity were more often associated with HSIL/CIN II + III than with LSIL/CIN I. Moreover, the frequencies of EGI, multicentricity, and positive ESM increased with increasing severity of the cervical lesion. This result may influence the preference for the type of surgical procedure used for patients with cytological diagnosis of HSIL. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - April 30, 2012 Category: OBGYN Authors: Gozde Kır, Murat Hakan Karabulut, Cumhur Selçuk Topal, Müberra Segmen Yılmaz Source Type: research

Randomized trial of albinterferon alfa‐2b every 4 weeks for chronic hepatitis C virus genotype 2/3
Summary. Albinterferon alfa‐2b (albIFN) is a fusion protein of recombinant human albumin/recombinant interferon (IFN)‐α‐2b, with ∼200‐h half‐life. Safety/efficacy of albIFN q4wk was evaluated in 391 treatment‐naive patients with chronic hepatitis C virus (HCV) genotype 2/3. Patients were randomized 3:4:4:4 to one of four open‐label treatment groups: pegylated IFN (Peg‐IFN)‐α‐2a 180 μg qwk or albIFN 900, 1200 or 1500 μg q4wk, plus oral ribavirin 800 mg/day, for 24 weeks. Primary efficacy endpoint was sustained virologic response (SVR; HCV RNA <20 IU/mL 24 weeks post‐treatment). ...
Source: Journal of Viral Hepatitis - March 22, 2012 Category: Infectious Diseases Authors: S. PiankoS. ZeuzemW.‐L. ChuangG. R. FosterS. K. SarinR. FlisiakC.‐M. LeeP. AndreoneT. PiratvisuthS. ShahA. SoodJ. GeorgeM. GouldP. KomolmitS. ThongsawatT. TanwandeeJ. RasenackY. LiM. PangY. YinG. FeutrenI. M. Jacobson Source Type: research

Discovery of a novel HLA‐B*51 variant, B*51:112, in a Taiwanese bone marrow donor and identification of the plausible HLA haplotype in association with B*51:112
SummaryThe sequence of B*51:112 is identical to the sequence of B*51:01:01 in exons 2, 3 and 4, except the nucleotides at positions 206 (C→A) and 213 (C→G). The nucleotide replacement caused one amino acid substitution at residue 45 (T→K). The plausible HLA‐A, ‐B and ‐DRB1 haplotype in association with B*51:112 may be deduced as HLA‐A*02‐B*51:112‐DRB1*12. The generation of B*51:112 was probably as the result of a DNA recombination event where B*40:01:01 acted as a sequence donor donating a segment of the DNA sequence to the recipient sequence B*51:01:01. The donor carrying B*51:112 was a Minna Taiwanese w...
Source: International Journal of Immunogenetics - March 16, 2012 Category: Genetics & Stem Cells Authors: K. L. YangS. K. LeeP. Y. Lin Tags: Short Communication Source Type: research

No Link Between LEEP and Preterm Birth
Major Finding: The odds ratios for LEEP patients vs. the group with a prior Pap smear were 0.9 for preterm birth prior to 32 weeks' gestation, 1.1 for preterm birth prior to 34 weeks, 1.0 for preterm birth prior to 37 weeks, and 1.2 for preterm birth prior to 20 weeks. The corresponding odds ratios for LEEP patients vs. those who had a prior cervical punch biopsy were 1.6, 1.6, 1.2, and 1.2. None of the findings reached statistical significance. (Source: Ob.Gyn. News)
Source: Ob.Gyn. News - March 1, 2012 Category: OBGYN Authors: SHARON WORCESTER Tags: Obstetrics Source Type: research

Analysis of circulating angiogenic biomarkers from patients in two phase III trials in lung cancer of chemotherapy alone or chemotherapy and thalidomide
& P J Woll (Source: British Journal of Cancer AOP)
Source: British Journal of Cancer AOP - February 21, 2012 Category: Cancer & Oncology Authors: R J YoungA W TinN J BrownM JitlalS M LeeP J Woll Source Type: research

No Sign of Increased Pregnancy Loss With LEEPNo Sign of Increased Pregnancy Loss With LEEP
Contrary to previous research, a large multicenter study shows no greater risk for pregnancy loss or preterm birth with loop electrosurgical excision procedures (LEEP). Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 9, 2012 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Source Type: news

No Jump in Preterm Birth After LEEP (CME/CE)
DALLAS (MedPage Today) -- Women who undergo loop electrosurgical excision procedures, or LEEP, for cervical dysplasia are not at risk for subsequent adverse pregnancy outcomes, a researcher said here. (Source: MedPage Today OB/GYN)
Source: MedPage Today OB/GYN - February 9, 2012 Category: OBGYN Source Type: news

Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV‐1
Polymorphisms in cell surface receptors of natural killer cells and their ligands on target cells can affect susceptibility to viral infections including human immunodeficiency virus (HIV)‐1. We found that the carriage of the human leukocyte antigen (HLA)‐G minus 14‐bp polymorphism, LILRB1 single nucleotide polymorphism rs1061680, and activating and inhibitory killer immunoglobulin‐like receptors (KIRs) were different when data were compared between Caucasian, African Americans and Asian populations. However, carriage was similar when HIV‐1 patients were compared with control donors, with the exception of the Afr...
Source: Tissue Antigens - February 2, 2012 Category: Allergy & Immunology Authors: M. Z. K. A. AghafarC. WittA. KamarulzamanR. IsmailM. M. LedermanB. RodriguezD. SenitzerS. LeeP. Price Source Type: research

Transport spectroscopy of symmetry-broken insulating states in bilayer graphene
J. Jung & A. H. MacDonald (Source: Nature Nanotechnology)
Source: Nature Nanotechnology - January 22, 2012 Category: Nanotechnology Authors: J. VelascoL. JingW. BaoY. LeeP. KratzV. AjiM. BockrathC. N. LauC. VarmaR. StillwellD. SmirnovFan ZhangJ. JungA. H. MacDonald Tags: Letter Source Type: research

A novel training model for the loop electrosurgical excision procedure: An innovative replica helped workshop participants improve their LEEP
We wanted to evaluate the feasibility and effect of a hands-on loop electrosurgical excision procedure (LEEP) 2.5-day intensive surgical skills workshop, using a novel training model on porcine tissue. Hands-on simulation-based training was conducted to emphasize colposcopy, local anesthesia, uterine cervix and vulva punch biopsy, LEEP, and complication management. Performance of 51 participants' technical skills was assessed before and after training completion. LEEP performance was significantly better after completion of the training (P < .001). Before and after training mean scores (SD) of 18.0 (3.5) and 23.4 (2.1) wer...
Source: American Journal of Obstetrics and Gynecology - January 16, 2012 Category: OBGYN Authors: Lukas Hefler, Christoph Grimm, Verena Kueronya, Clemens Tempfer, Alexander Reinthaller, Stephan Polterauer Tags: Surgeon's Corner Source Type: research

Detection of two HLA‐B*27 alleles, B*27:25 and B*27:86, in two Taiwanese blood donors by sequence‐based typing
We report here two HLA‐B*27 alleles, B*27:86 and B*27:25, found in two Taiwanese blood donors. The new sequence of B*27:86 is identical to B*27:04:01 in exons 2 and 3, except at nucleotide 602 (A→G) in exon 3. The nucleotide change caused an amino acid substitution from E to G at amino acid residue 177. The sequence of B*27:25 is identical to B*27:04:01 in exons 2, 3, 4, 5, 6 and 7 except at nucleotides 538, 539, 559 and 560 in exon 4. The nucleotide changes caused amino acid substitutions from L to W and from E to L at residues 156 and 163, respectively. The generation of B*27:86 was probably resulted by a point mutat...
Source: International Journal of Immunogenetics - January 9, 2012 Category: Genetics & Stem Cells Authors: E. K. L. YangS. K. LeeP. Y. Lin Tags: Short Communication Source Type: research

Follow-up after LLETZ: a study of 682 cases of CIN 2–CIN 3 in a single institution
Abstract: Objective: To evaluate the importance of resection margins in the risk of persistent/recurrent lesions and to investigate other factors such as detection of high-risk HPV, which could potentially predict persistent/recurrent disease before patients engage in follow-up.Study design: 682 women with a histologically confirmed diagnosis of CIN 2–3 treated by loop electrosurgical excision procedure (LEEP) were included, between January 2000 and December 2006. Age, high-risk HPV detection determined by Hybrid Capture II and cone margins were evaluated as possible predictors of persistent/recurrent disease.Results: Th...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - November 28, 2011 Category: OBGYN Authors: Amina Lubrano, Norberto Medina, Virginia Benito, Octavio Arencibia, Juan Miguel Falcón, Laureano Leon, Jesús Molina, Orlando Falcón Tags: Gynaecology and Gynaecological Oncology Source Type: research

Inpatient and outpatient loop electrosurgery excision procedure for cervical intraepithelial neoplasia: a retrospective analysis
Conclusion Our results suggest that efficacy and safety of ambulatory LEEP conization is comparable as in inpatient procedure. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-5DOI 10.1007/s00404-011-2148-7Authors B. Leimbacher, Department of Gynecology, University Hospital of Zurich, Frauenklinikstrasse 10, 8091 Zurich, SwitzerlandN. Samartzis, Department of Gynecology, University Hospital of Zurich, Frauenklinikstrasse 10, 8091 Zurich, SwitzerlandP. Imesch, Department of Gynecology, University Hospital of Zurich, Frauenklinikstrasse 10, 8091 Zurich, SwitzerlandK. J. Dedes, Department o...
Source: Archives of Gynecology and Obstetrics - November 24, 2011 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: research

Florid reactive lymphoid hyperplasia (lymphoma-like lesion) of the uterine cervix
We describe the clinicopathologic features of 6 patients with LLL involving the uterine cervix. Five patients presented with abnormal Papanicolaou test (Pap smear), and 3 patients had a biopsy procedure performed prior to detection of LLL in a loop electrosurgical excision procedure (LEEP). In each specimen, surface epithelial erosion was associated with a superficial, polymorphous lymphoid infiltrate with numerous scattered large cells, without cellular necrosis or sclerosis. Squamous dysplasia was present in 4 patients. Immunohistochemical studies revealed a mixed population of B- and T-lymphoid cells. T-cells were more ...
Source: Annals of Diagnostic Pathology - November 7, 2011 Category: Pathology Authors: Preetha Ramalingam, Pablo Zoroquiain, José R. Valbuena, Bonnie L. Kemp, L. Jeffrey Medeiros Tags: Original Contributions Source Type: research

Prevalence and diversity of allergic rhinitis in regions of the world beyond Europe and North America
Conclusions and Clinical RelevanceOur findings suggest that the greater diversity in prevalence of AR or AR/C in populations in these regions is in contrast to the lower diversity of AR or AR/C in the ‘western populations (USA and Europe), which tend to be more uniform. This review provides a comprehensive database of the important allergens and triggers which are likely to influence the prevalence of allergic rhinitis in these diverse regions, where the prevalence of allergic rhinitis is increasing and its adverse impact on the quality of life of affected individuals is increasingly recognised. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - November 3, 2011 Category: Allergy & Immunology Authors: C. H. KatelarisB. W. LeeP. C. PotterJ. F. MasperoC. CingiA. LopatinM. SafferG. XuR. D. Walters Tags: Review Source Type: research

External quality assurance for image grading in the Scottish Diabetic Retinopathy Screening Programme
Conclusions: A useful educational tool has been developed for image grading external quality assurance. (Source: Diabetic Medicine)
Source: Diabetic Medicine - October 24, 2011 Category: Endocrinology Authors: K. A. GoatmanS. PhilipA. D. FlemingR. D. HarveyK. K. SwaC. StylesM. BlackG. SellN. LeeP. F. SharpJ. A. Olson Source Type: research

The association between obesity and mortality in the elderly differs by serum concentrations of persistent organic pollutants: a possible explanation for the obesity paradox
bs & D-H Lee (Source: International Journal of Obesity)
Source: International Journal of Obesity - September 27, 2011 Category: Eating Disorders and Weight Management Authors: N-S HongK-S KimI-K LeeP M LindL LindD R JacobsD-H Lee Tags: obesity paradox persistent organic pollutants fat mass elderly mortality Source Type: research

Unexpected tumor progression after conization for carcinoma in situ of the uterine cervix
Conclusion: This study indicates that patients with CIS occasionally show unexpected tumor progression after conization and the progression could be life‐threatening. Recurrent disease often shows tumor progression toward the endometrium or vagina, leading to difficulties in its detection at periodic pelvic examinations. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - September 15, 2011 Category: OBGYN Authors: Kohei OmatsuNobuhiro TakeshimaMaki MatodaHidetaka NomuraKenji UmayaharaYuko SugiyamaKuniko UtsugiHiroko TanakaFutoshi AkiyamaKen Takizawa Source Type: research

Loop electrosurgical excision procedure: safety and tolerability among human immunodeficiency virus-positive kenyan women.
CONCLUSION: : LEEP performed by clinical officers was well-accepted by HIV-positive women and appears safe, resulting in minimal side effects, even among women with early resumption of intercourse. LEVEL OF EVIDENCE: : II. PMID: 21860283 [PubMed - in process] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - August 27, 2011 Category: OBGYN Authors: Woo VG, Cohen CR, Bukusi EA, Huchko MJ Tags: Obstet Gynecol Source Type: research

Second-half-of-the-day headache as a manifestation of spontaneous CSF leak
The objective of this study is to describe second-half-of-the-day headache as a manifestation of spontaneous CSF leak and propose potential mechanisms. From 142 patients evaluated by one of us (B.M.) during a 10-year period for spontaneous intracranial hypotension, those describing headache occurring exclusively in the afternoon accompanied by typical changes of intracranial hypotension on head MRI were retrospectively identified and their medical records reviewed. Five patients met our pre-defined inclusion criteria (5/142, 3.5%; three women; mean age 50 years). Second-half-of-the-day headache was an initial sym...
Source: Journal of Neurology - August 2, 2011 Category: Neurology Tags: Journal of Neurology Source Type: research

Management of hematocervix after loop electrosurgical excision procedure.
: Management is not established for the uncommon complication of cervical stenosis secondary to a loop electrosurgical excision procedure resulting in a hematocervix. PMID: 21768861 [PubMed - in process] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - July 30, 2011 Category: OBGYN Authors: Perino AC, Python J, Thompson LC Tags: Obstet Gynecol Source Type: research