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Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Legal Medicine)
Source: Legal Medicine - November 1, 2009 Category: Forensic Medicine Source Type: journals

More descriptive sub-coding for the source or place of carbon monoxide poisoning would be required for the revision of ICD-11Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the statistics of accidental and suicidal death due to CO poisoning with reference to gender, age, month and place from The vital statistics submitted by the Ministry of Health, Labour and Welfare in Japan . The statistics show an increase in the number of lethal CO poisoning accidents from 1998 to 2007. Approximately two thirds of the accidental CO poisoning occurs during cold season (from November to April), and more than half at home. There have been many news reports on CO poisoning due to defects in household gas appliances, and manufacturer’s negligence, but the statistics do not tell the truth. (Source: Legal Medicine)
Source: Legal Medicine - October 15, 2009 Category: Forensic Medicine Authors: Hiroshi Kinoshita, Koichi Terazawa, Yasuhiro Aoki, Masahito Hitosugi, Haruo Yamanouchi, Emiko Oikawa, Kazushi Yamauchi, Ken-ichi Yoshida Tags: Letter to the Editor Source Type: journals

A fatal case of myocardial damage due to misuse of the “designer drug” MDMAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A 39-year-old woman collapsed after oral intake of 3,4-methylenedioxymethyl-amphetamine (MDMA, “ecstasy”). After ingestion of the drug, she had felt persistent discomfort in her anterior chest area, and lost consciousness for a few minutes on the following morning. She was transported to a hospital and died seven days after collapse. A serum sample obtained on admission revealed an MDMA concentration of 1.2mg/L, but no evidence of any other drug including amphetamine, methamphetamine, or other ring-substituted amphetamines. Microscopic examination at autopsy revealed striking changes in the heart, including s...
Source: Legal Medicine - October 15, 2009 Category: Forensic Medicine Authors: Rie Sano, Toshikazu Hasuike, Minoru Nakano, Yoshihiko Kominato, Hideaki Itoh Tags: Case Reports Source Type: journals

C-fos, fos-B, c-jun and dusp-1 expression in the mouse heart after single and repeated methamphetamine administrationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In forensic autopsy, there are numerous sudden methamphetamine (MA)-related deaths. The concentration of MA in the blood is measured to determine the cause of death in case of MA-related death. As a low concentration of MA is detected in MA-related death cases, it is sometimes difficult to identify to the cause of death. MA abusers often exhibit various cardiovascular diseases. MA induces arrhythmia and morphological change in cultured cardiomyocytes. Therefore, MA might affect heart cells, especially in terms of gene expression. Immediate early genes (IEGs) are expressed before some specific gene expressions fol...
Source: Legal Medicine - October 15, 2009 Category: Forensic Medicine Authors: Aya Matsuo, Kazuya Ikematsu, Ichiro Nakasono Tags: Original Articles Source Type: journals

Frequency, types and causes of intraventricular haemorrhage in lethal blunt head injuriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Autopsy findings and neuropathological examination of formalin-fixed brains in 676 deaths due to blunt head injury, here with special attention to injuries of the inner (periventricular) cerebral structures and haemorrhages into the ventricles.Intraventricular haemorrhage of any degree was present in 17.6%, considering only distinct and massive haemorrhage in 10% of all cases. Considering the types of trauma, the frequency was lowest in ground level falls and highest in traffic accidents (pedestrians with head contact to the car) – indicating a relation between the severity of impacts and the likelihood of vent...
Source: Legal Medicine - October 15, 2009 Category: Forensic Medicine Authors: H. Maxeiner, Cynthia Schirmer Tags: Original Articles Source Type: journals

A study of neutrophil as a morphological marker of death from hemorrhagic shock in forensic practice casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Excessive autolytic inflammation accompanied by dysfunction of “shock organs” is recognized as arising from hemorrhagic shock due to the promotion of endovascular recruitment of neutrophils. Here, activated neutrophils in the organs of autopsy cases were evaluated as a marker of death from hemorrhagic shock. Morphologically-determined injury to the heart, lung, liver, and kidney was investigated in death from five major causes: hemorrhagic shock, head injury, exsanguination, asphyxia, and drowning. The frequency of activated neutrophils was assessed by immunohistochemical staining. When the antemortem interva...
Source: Legal Medicine - October 15, 2009 Category: Forensic Medicine Authors: Hiroaki Sato, Toshiro Kita, Toshiko Tanaka, Kentaro Kasai, Noriyuki Tanaka Tags: Original Articles Source Type: journals

Diplotype analysis of the human cardiac sodium channel regulatory region in Japanese cases of sudden death by unknown causesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Inherited mutations in the human cardiac sodium channel (SCN5A) gene cause arrhythmogenic diseases such as tachyarrhythmia and bradyarrhythmia. Moreover, mutation subsets in the coding region impair SCN5A function, potentially leading to sudden cardiac death (SCD). In the present study, we performed diplotype analysis of the regulatory region of the SCN5A gene in Japanese people who died suddenly because of an unknown cause (sudden death group; n=70) and controls (n=112). There were no significant differences at six polymorphic loci between the groups. However, 38 diplotypes of 6-nucleotide polymorphism variants ...
Source: Legal Medicine - October 12, 2009 Category: Forensic Medicine Authors: Masato Nakatome, Takuma Yamamoto, Ichiro Isobe, Ryoji Matoba Tags: Brief Communication Source Type: journals

A novel method for the diagnosis of drowning by detection of Aeromonas sobria with PCR methodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, from the preserved blood samples of 32 freshwater drowning cases, specific DNA fragments of Aeromonas sobria, one of the most common aquatic bacteria, were examined using PCR. The DNA fragments of the bacterium were detected from 27 of 32 cases with first round PCR or nested-PCR. The remaining 5 cases in which bacterial DNA was not detected had longer storage periods for the blood samples and shorter time intervals from drowning to death. These results indicate that the present method can be applied to the diagnosis of death by drowning. (Source: Legal Medicine)
Source: Legal Medicine - September 18, 2009 Category: Forensic Medicine Authors: Miwako Aoyagi, Kimiharu Iwadate, Kenji Fukui, Shuntaro Abe, Kentaro Sakai, Kyoko Maebashi, Eriko Ochiai, Mihoko Nakamura Tags: Original Articles Source Type: journals

Allele frequency distribution for 15 autosomal STR loci in Afridi Pathan population of Uttar Pradesh, IndiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Allele frequencies of the 15 autosomal short tandem repeat (STR) loci D8S1179, D21S11, D7S820, CSF1PO D19S433, vWA, TPOX, D18S51, D3S1358, THO1, D13S317, D16S539, D2S1338, D5S818 and FGA were determined in Afridi Pathan population of Uttar Pradesh, India. All the 15 STR loci studied were found to be highly polymorphic with respect to observed heterozygosity values. Adherence to the expectations of the Hardy–Weinberg equilibrium (HWE) was confirmed for all the loci with an exception of TPOX and FGA. The allele 12 in CSF1PO was found to be most frequent. The power of discrimination was found to be high ranging fr...
Source: Legal Medicine - September 9, 2009 Category: Forensic Medicine Authors: Sabahat Noor, Shahnaz Ali, Muthukrishnan Eaaswarkhanth, Ikramul Haque Tags: Announcements of Population Data Source Type: journals

Population genetic data on 15 autosomal STRs in a Pakistani population sampleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Allele frequencies for the 15 STR loci (D3S1358, TH01, D21S11, D18S51, Penta E, D5S818, D13S317, D7S820, D16S539, CSF1PO, Penta D, VWA, D8S1179, TPOX and FGA) were investigated using PowerPlex®16 amplification kit in a sample of 328 unrelated individuals from Islamic Republic of Pakistan. The allelic distributions were in Hardy Weinberg equilibrium for all loci except for the loci FGA, TPX and THO1. Various forensic indices were calculated and a comparison was made with geographically nearby populations. (Source: Legal Medicine)
Source: Legal Medicine - September 9, 2009 Category: Forensic Medicine Authors: Allah Rakha, Bing Yu, S. Hadi, Li Sheng-bin Tags: Announcements of Population Data Source Type: journals

Population genetic data for 15 STR loci (Identifiler™ kit) in BoliviaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Allele frequencies for 15 STR autosomal loci (D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, VWA, TPOX, D18S51, D5S818 and FGA) were obtained from a sample of 200 unrelated individuals from Bolivia, South America. (Source: Legal Medicine)
Source: Legal Medicine - September 9, 2009 Category: Forensic Medicine Authors: Omar Rocabado, Patricia Taboada, Francisco Javier Inda, Inaki Yurrebaso, Oscar García Tags: Announcements of Population Data Source Type: journals

An infantile case of asphyxia with coincidental myocarditisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A six-month-old infant was found dead in a small dustbin in an upside-down position. The police investigation showed that there was no criminal environment including negligence. Analysis at the scene suggested death caused by asphyxia (wedging death). Microscopically, however, diffuse lymphocyte infiltration was observed in the interstitial spaces of the myocardium. Common symptoms of infantile myocarditis are generally non-specific, and the predominant neurological problem is a decrease in activity. The records of rectal temperature suggested that the decedent was dead without a high fever. In the present case, ...
Source: Legal Medicine - September 7, 2009 Category: Forensic Medicine Authors: Jun Sakai, Takuya Moriya, Shirushi Takahashi, Masaki Hashiyada, Masato Funayama Tags: Case Reports Source Type: journals

Post-mortem imaging of laryngohyoid fractures in strangulation incidents: First resultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we examined the usefulness of post-mortem imaging with multislice computed tomography (MSCT) in detecting lesions of the laryngohyoid structures and the surrounding soft-tissues. For this purpose, we examined MSCT images of the neck of eight deceased persons who had suffered different types of strangulation and compared the findings with those obtained at the subsequent forensic autopsy.In six of the eight cases (75%), the fracture findings at autopsy were concordant with those found with MSCT. In the two non-congruent cases, MSCT revealed fractures, which were not discovered at autopsy.Soft-tissue haemorrha...
Source: Legal Medicine - September 7, 2009 Category: Forensic Medicine Authors: M. Kempter, S. Ross, D. Spendlove, P.M. Flach, U. Preiss, M.J. Thali, S.A. Bolliger Tags: Original Articles Source Type: journals

Stature estimation formulae from radiographically determined limb bone length in a modern Japanese populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to derive regression formulae for stature estimation from long limb bones in a Japanese population. Moreover, commonly employed estimation equations, such as that of Fujii, were re-evaluated through application of current data. To construct equations, measurements were conducted on 434 living subjects (342 females and 92 males; 18–59years old). The whole or maximum length of the femur, tibia, and humerus was determined radiographically using dual-energy X-ray absorptiometry, which permitted measurement of long bones with no magnification. Regression formulae were constructed for females an...
Source: Legal Medicine - September 7, 2009 Category: Forensic Medicine Authors: Iwao Hasegawa, Kazuhiro Uenishi, Tatsushige Fukunaga, Ryousuke Kimura, Motoki Osawa Tags: Original Articles Source Type: journals

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(Source: Legal Medicine)
Source: Legal Medicine - August 18, 2009 Category: Forensic Medicine Source Type: journals

Fulminant sepsis due to anaerobic bacterial infection in immuno-compromised stateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We experienced two autopsy cases of fulminant sepsis due to anaerobes. Case 1: A 67-year-old female with uncontrolled diabetes mellitus (DM) was admitted to a hospital because of sudden onset of mid-abdominal pain. She was diagnosed with infectious colitis and given a laxative and an enema. However, 9h later, her blood pressure suddenly dropped with metabolic acidosis, and she died 20h after admission. Autopsy revealed massive pneumohemia and a dark-brown colored mucosal surface from the terminal ileum to the sigmoid colon. Histopathological findings were compatible with marginal ischemic colitis. Anaerobes were ...
Source: Legal Medicine - August 2, 2009 Category: Forensic Medicine Authors: Hideto Suzuki, Kazumoto Murata, Atsushi Sakamoto Tags: Case Reports Source Type: journals

A fetal autopsy case of body stalk anomalyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Body stalk anomaly (BSA) is a sporadic polymalformative syndrome incompatible with extrauterine life. In utero detection of BSA by two-dimensional and three-dimensional ultrasonography and magnetic resonance imaging has been well documented. We herein describe a case of body stalk anomaly diagnosed at autopsy. The fetus had a large anterior midline abdominal wall defect with eventration of the visceral organs into the amnio-peritoneal sac and a completely absent umbilical cord. The associated anomalies included club foot, absent diaphragm, genitourinary, and gastrointestinal defects. The observed congenital anoma...
Source: Legal Medicine - July 29, 2009 Category: Forensic Medicine Authors: Alka Mary Mathai, Ritesh G. Menezes, Suneet Kumar, Muktha R. Pai, Amritha Bhandary, Valerie A. Fitzhugh Tags: Case Reports Source Type: journals

Morphology of lymphatic regeneration in rat incision wound healing in comparison with vascular regenerationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In the wound healing process, angiogenesis is involved in the recovery of vasculature, and its process has been investigated. On the other hand, the reconstruction of lymphatic vessels in the injured subcutaneous tissue has not been studied in detail. We studied the recovery of lymphatic vessels using podoplanin immunohistochemistry in the paraffine section microscopy of the rat skin incision wound. Our result indicates a novel finding that subcutaneous tissue of the incised skin area does not show any recovery of lymphatic vessels up to 84days after the skin incision. As the wound area shrunk, the surrounding su...
Source: Legal Medicine - July 23, 2009 Category: Forensic Medicine Authors: Makoto Nogami, Tomoaki Hoshi, Tomomi Arai, Yoko Toukairin, Michiho Takama, Ichiro Takahashi Tags: Original Articles Source Type: journals

Population data for 12 Y-chromosome STR loci in a sample from HondurasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Haplotype, allele frequencies and population data of 12 Y-chromosome STR loci DYS19, DYS385, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438 and DYS439 were determined from a sample of 128 unrelated male individuals from Honduras, Central America. A total of 112 haplotypes were identified by the 12 Y-STR loci of which 98 were unique. The haplotype diversity (98.99%) and the proportion of different haplotypes (87.50%) were estimated. Genetic distances were calculated between Honduras and other populations from Southern and Central America, Europe and Africa. The analysis of a Multi Dimensional Sc...
Source: Legal Medicine - July 22, 2009 Category: Forensic Medicine Authors: Mireya Matamoros, Iñaki Yurrebaso, Leonor Gusmão, Oscar García Tags: Announcements of Population Data Source Type: journals

Characteristic features of injuries due to shark attacks: A review of 12 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the characteristic features of shark injuries on 12 corpses. The analysis of these injuries might reveal the motivation behind the attacks and/or the shark species involved in the attack. Gouge marks on the bones are evidence of a shark attack, even if the corpse is decomposed. Severance of the body part at the joints without a fracture was found to be a characteristic feature of shark injuries. (Source: Legal Medicine)
Source: Legal Medicine - July 21, 2009 Category: Forensic Medicine Authors: Yoko Ihama, Kenji Ninomiya, Masamichi Noguchi, Chiaki Fuke, Tetsuji Miyazaki Tags: Original Articles Source Type: journals

Fatal intoxication with naftidrofurylEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A 52-year-old man was found dead in his bed. He had financial and psychosocial problems like separation from his wife and children or unemployment due to alcoholism. Under treatment of disulfiram he was presently abstinent from alcohol. As he had suffered from epileptic seizures and dizziness, he received valproic acid and the vasodilator naftidrofuryl, respectively. Autopsy showed no morphologic cause of death. Chemical analysis of blood revealed concentrations for valproic acid and disulfiram in the therapeutic and above the therapeutic range but far below the lethal level, respectively. No ethanol was found. H...
Source: Legal Medicine - June 10, 2009 Category: Forensic Medicine Authors: Michael F. Koller, Martin Schmid, Peter X. Iten, Bruno Vonlanthen, Walter Bär Tags: Case Reports Source Type: journals

A case of acute myocardial infarction after intracoronary stent implantation: Demonstration of the stent location by postmortem X-ray examinationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, X-ray examination seems to be an effective adjunct in forensic pathology for localization of an implanted coronary stent and careful investigation of the coronary artery surrounding the stent. (Source: Legal Medicine)
Source: Legal Medicine - June 10, 2009 Category: Forensic Medicine Authors: Yutaka Tajima, Rie Takagi, Yoshihiko Kominato Tags: Case Reports Source Type: journals

A multiplex PCR for 4 X chromosome STR markers and population data from Beijing Han ethnic groupEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: STR multiplex is a practical and simple method to obtain large amounts of important information in forensic and population genetic studies. The present work describes a new multiplex system that allows the simultaneous analysis of 4 X-STR markers, namely DXS9902, DXS6800, DXS6799 and DXS7132, as the tool of approach for X-STR studies. In addition, this work presents the genotyping results obtained for a sample 400 individuals (200 males and 200 females) from Beijing Han ethnic group in China. (Source: Legal Medicine)
Source: Legal Medicine - June 9, 2009 Category: Forensic Medicine Authors: Huifen Li, Hui Tang, Qinxia Zhang, Zhangping Jiao, Jie Bai, Shoupeng Chang Tags: Announcements of Population Data Source Type: journals

von Willebrand factor in cadaveric urine for forensic investigationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study indicated the possibility that urinalysis would be helpful to estimate PMI. (Source: Legal Medicine)
Source: Legal Medicine - June 9, 2009 Category: Forensic Medicine Authors: Shogo Kasuda, Risa Kudo, Yoshifumi Morimura, Kohei Tatsumi, Yoshihiko Sakurai, Midori Shima, Katsuhiko Hatake Tags: Brief Communication Source Type: journals

Mast cell tryptase in a case of anaphylaxis due to repeat antibiotic exposureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Mast cell tryptase can be an indicator of type I hypersensitivity reaction and thus may serve as a surrogate marker of anaphylaxis. A 34-year-old white male patient presented with a history of systemic lupus erythematosus. Shortly after administration of cefazolin for dialysis, he developed pruritis and shortness of breath. He expired an hour later. Autopsy excluded anatomic causes of death. There was an elevated postmortem mast cell tryptase level, 29.2ng/mL. For mast cell tryptase level to be useful, the patient must survive long enough after exposure to an allergen for mast cells to release this enzyme. A cred...
Source: Legal Medicine - June 9, 2009 Category: Forensic Medicine Authors: Henry J. Carson, Benjamin A. Cook Tags: Case Reports Source Type: journals

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(Source: Legal Medicine)
Source: Legal Medicine - May 21, 2009 Category: Forensic Medicine Source Type: journals

Allele frequencies and haplotypes for 28 Y-STRs in Ovambo populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Y-chromosomal 28 short tandem repeat (STR) loci were investigated in unrelated healthy individuals of the Ovambo population from Namibia (n=54). Sixteen Y-chromosome short tandem repeat (Y-STR) polymorphic loci (DYS456, DYS389I, DYS390, DYS389II, DYS458, DYS19, DYS385, DYS393, DYS391, DYS439, DYS635, DYS392, GATAH4, DYS437, DYS438, and DYS448) were analyzed using AmpFISTR Yfiler Polymerase Chain Reaction (PCR) Amplification Kit. DYS441–445 and DYS446, DYS447, DYS449, DYS450, DYS459a/b, DYS463 and DYS464a/b/c/d were investigated using a multiplex PCR system. Fifty-one haplotypes were identified in 54 Ovambos. Th...
Source: Legal Medicine - May 13, 2009 Category: Forensic Medicine Authors: Junko Fujihara, Isao Yuasa, Tomonori Muro, Reiko Iida, Etsuko Tsubota, Hiroaki Nakamura, Shinji Imamura, Toshihiro Yasuda, Haruo Takeshita Tags: Announcements of Population Data Source Type: journals

Forensic genetic analysis of nine miniSTR loci in the Korean populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Nine miniSTR loci were analyzed in 191 unrelated individuals from Korea using three multiplex PCR systems (multiplex I: D1S1677, D2S441 and D4S2364; multiplex II: D10S1248, D14S1434 and D22S1045; multiplex III: D12S391, D16S3253 and D20S161). Due to the short PCR amplicons ( (Source: Legal Medicine)
Source: Legal Medicine - May 8, 2009 Category: Forensic Medicine Authors: Myun Soo Han, Yang Seop Kim, Han Jun Jin, Jong Jin Kim, Kyoung Don Kwak, Jong Eun Lee, Joon Myong Song, Wook Kim Tags: Announcements of Population Data Source Type: journals

Wound age estimation by simultaneous detection of 9 cytokines in human dermal wounds with a multiplex bead-based immunoassay: An estimative method using outsourced examinationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Wound age estimation for human dermal wounds was performed based on quantification of interleukin 1β (IL 1β), IL 5, IL 7, IL 12 p70, IL 13, IL 17, granulocyte colony-stimulating factor (G-CSF), monocyte chemoattractant protein 1 (MCP 1), and macrophage inflammatory protein 1β (MIP 1β). IL 5, IL 12 p 70, IL 13, and IL 17 increased from the early phase, MCP 1 exclusively in the middle phase, and IL 1β, G-CSF, and MIP 1β from the middle phase to the late phase. IL 7 decreased from the early phase. Among the cytokines analyzed in the present study, MCP 1 was the most plentiful cytokine. In addition, an outsourc...
Source: Legal Medicine - May 6, 2009 Category: Forensic Medicine Authors: Masataka Takamiya, Hitoshi Biwasaka, Kiyoshi Saigusa, Nori Nakayashiki, Yasuhiro Aoki Tags: Original Articles Source Type: journals

Population data for 15 STR loci (Identifiler® kit) in a Filipino populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Allele frequencies for fifteen STR loci, D3S1358, TH01, D21S11, D18S51, D2S1338, D5S818, D13S317, D7S820, D16S539, CSF1PO, D19S433, vWA, D8S1179, TPOX and FGA, were investigated in a Filipino ethnic group resident in the United States and in the Philippines. Statistical evaluation of the data collected indicated the population to be in Hardy–Weinberg equilibrium and therefore acceptable for calculations in forensic and family relatedness casework. (Source: Legal Medicine)
Source: Legal Medicine - April 17, 2009 Category: Forensic Medicine Authors: Brenda G. Smith, Brent Lee, Bruce Budowle, Robert W. Allen Tags: Announcements of Population Data Source Type: journals

Allele frequencies of 15 autosomal STR loci in the southern Morocco population with phylogenetic structure among worldwide populationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Polymerase chain reaction (PCR) amplification using the AmpFl STR Identifiler kit was performed in a random sample of 204 unrelated individuals from the Arabic-speaking population of the southern Morocco. Allele frequencies of 15 STRs loci (D13S317, D16S539, D2S1338, vWA, TPOX, D18S51, D5S818, FGA, D8S1179, D21S11, D7S820, D19S433, CSF1PO, TH01 and D3S1358) have been reported in this population. Markers D18S51, FGA, D2S1338 and D21S11 had the highest power of discrimination (PD) values while TH01 was the most informative locus in the studied population. The phylogenetic tree established among worldwide population...
Source: Legal Medicine - April 17, 2009 Category: Forensic Medicine Authors: Hicham El Ossmani, Jalal Talbi, Brahim Bouchrif, Abdelaziz Chafik Tags: Announcements of Population Data Source Type: journals

Genetic polymorphisms of 10 X-chromosome STR loci in Chinese Daur ethnic minority groupEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The population genetic data of 10 X-chromosomal short tandem repeats (STR) loci DXS101, DXS7130, DXS6804, DXS7133, DXS7132, DXS6799, DXS8378, DXS6789, DXS7423 and HPRTB were analyzed in samples of unrelated individuals from Chinese Daur population. Average heterozygosity of above 10 STR loci was 0.6489 and the DXS6789 was the most polymorphic. The exact test for female data showed no significant deviation from the Hardy–Weinberg equilibrium (P>0.05). Allele frequencies between male and female samples were not significantly different in all examined loci. Further, the allelic frequencies of Daur ethnic populatio...
Source: Legal Medicine - April 17, 2009 Category: Forensic Medicine Authors: Xiaoyan Zeng, Allah Rakha, Shengbin Li Tags: Announcements of Population Data Source Type: journals

Genetic profiling of Bolivian population using 15 STR markers of forensic importanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Allele frequencies for the 13 CODIS markers plus D2S1358 and D19S433 loci were estimated in a sample of 148 unrelated individuals from Bolivia and parameters of forensic interest were calculated. Further, the STR data were analyzed using a distance-based method to assess the genetic relationships of this population with other ones living in Argentina, Brazil, Costa Rica, Mexico, Peru, Venezuela and three autochthonous populations living in the Beni Department of Bolivia (Quechua, Aymara and Beni population). (Source: Legal Medicine)
Source: Legal Medicine - April 17, 2009 Category: Forensic Medicine Authors: Laura Natalia Riccardi, German Melean, Ana Rada, Noemi Tirado, Maurizio Genuardi, Ugo Ricci Tags: Announcements of Population Data Source Type: journals

Population genetics of six miniSTR loci (D1S1677, D2S441, D4S2364, D10S1248, D14S1434, D22S1045) in a Polish populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Allele frequency data and forensic efficiency parameters for six miniSTR loci: D1S1677, D2S441, D4S2364 (NC01), D10S1248, D14S1434, D22S1045 (NC02) were estimated from a sample of 116 unrelated individuals from Poland. No significant deviations from Hardy–Weinberg equilibrium expectations were detected. The combined power of discrimination for the six studied loci was 0.999995383. (Source: Legal Medicine)
Source: Legal Medicine - April 17, 2009 Category: Forensic Medicine Authors: Monika Reichert, Ryszard Pawłowski Tags: Announcements of Population Data Source Type: journals

Genetic analyzing of 15 STR loci in a Han population of Jinan (northern China)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study reports the genetic polymorphic data of 15 autosomal STRs D3S1358, TH01, D21S11, D18S51, D5S818, D13S317, D7S820, D16S539, CSF1PO, vWA, D8S1179, TPOX, D2S1338, D19S433, and FGA observed in Han ethnic group living in Jinan, Shandong, China. The combined match probability and exclusion probability for 15 loci was 3.89×10−17 and 0.99997, respectively. No mutations at these loci were found in 78 pedigrees, and Chi-test of allelic frequencies in 420 unrelated samples showed no departure from Hardy-Weinberg equilibrium at these loci. The pairwise comparisons between Jinan and 41 reference populations were performed...
Source: Legal Medicine - April 17, 2009 Category: Forensic Medicine Authors: Jianpin Tang, Jian Zhang, Fenghui Jiang, Xiaojun Yu Tags: Announcements of Population Data Source Type: journals

Identification of malignant hyperthermia-susceptible ryanodine receptor type 1 gene (RYR1) mutations in a child who died in a car after exposure to a high environmental temperatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Malignant hyperthermia (MH) is a genetic disorder of skeletal muscle in susceptible individuals that is triggered by exposure to anesthetic agents, and can cause death. Mutations in the ryanodine receptor type 1 gene (RYR1) are associated with MH-susceptibility. MH is also triggered in susceptible individuals by severe exercise in hot conditions or by overheating in infants. Here, we report a case of a child, 2years, 9months of age, who was left in a car and exposed to a high environmental temperature. The child was suspected to have died of heat stroke by autopsy examinations. Postmortem mutation analysis reveal...
Source: Legal Medicine - April 17, 2009 Category: Forensic Medicine Authors: Hajime Nishio, Takako Sato, Shinya Fukunishi, Akiyoshi Tamura, Misa Iwata, Kento Tsuboi, Koichi Suzuki Tags: Case Reports Source Type: journals

‘Rib betrays heart’—A case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Penetrating or stab injuries of the chest are not uncommon and could be accidental, suicidal or homicidal. However, the present case discusses the importance of a careful examination of an unusual presentation in a motor vehicle accident. The case presented with haemopericardium and haemothorax due to penetrating rib injury to the heart, subsequent to blunt force trauma on the posterior chest wall. This case is highlighted, so that it becomes a necessary tool for the forensic experts to have an unprejudiced approach at autopsy and come to a reasonable conclusion. (Source: Legal Medicine)
Source: Legal Medicine - April 17, 2009 Category: Forensic Medicine Authors: B. Suresh Kumar Shetty, Y.P. Raghavendra Babu, K.S. Muhammed Sameer, Preetham Raj Salian, Mahabalesh Shetty, Shahnavaz Manipady, K. Pradyumna Majumdar Tags: Case Reports Source Type: journals

Post-mortem CT findings following intentional ingestion of mercuric chlorideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Mercury is known to be associated with both acute and chronic poisoning. A 36-year-old man intentionally ingested mercuric chloride (HgCl2) and died within 24h. Post-mortem CT images showed oral, esophageal and gastric wall hyperdense “staining”. On toxicological analysis, the blood concentration of mercury was measured at 25.5mg/L; a figure far higher than reported lethal levels. Autopsy was not performed in order to prevent potential inhalation of mercury vapor by pathology staff. (Source: Legal Medicine)
Source: Legal Medicine - April 17, 2009 Category: Forensic Medicine Authors: Morio Iino, Christopher J. O’Donnell, Michael P. Burke Tags: Case Reports Source Type: journals

An accidental case of aconite poisoning due to Kampo herbal medicine ingestionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: An accidental case of aconite intoxication occurred after a patient took a therapeutic dose of Kampo herbal medicine containing Aconiti tuber, Uzu but had used the wrong decoction procedure. The poisoning was likely caused by an increased level of Aconitum alkaloids in the decoction; the patient developed aconite intoxication due to incomplete decoction. Aconitum alkaloid levels in the leftover solution which the patient had drunk and in the decoction extracted from 3g Uzu were determined. It was found that decoction makes the medicine safer to drink. Older individuals, especially those with dementia, have a high...
Source: Legal Medicine - April 17, 2009 Category: Forensic Medicine Authors: Takiyoshi Ono, Makiko Hayashida, Kyoko Uekusa, Cui Fan Lai, Hideyuki Hayakawa, Makoto Nihira, Youkichi Ohno Tags: Case Reports Source Type: journals

Identification of newly polymorphic intron 40 markers of the von Willebrand factor gene in a Japanese populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We investigated a region of repetitive DNA located in intron 40 of the von Willebrand factor (vWF) gene (nucleotides [nt] 1639–2404; i.e., F8VWF). We identified 13 alleles and 33 genotypes in 49 unrelated Japanese individuals. The heterozygosity of the region was 0.897. Direct sequence analyses revealed five single-base substitutions, one tetranucleotide (TTAT) insertion, and seven short tandem repeats (STRs) in the intron; four of the STRs and one single-base substitution had been reported previously. The four new base substitutions we identified were 1849T>A, 2122C>T, 2180C>T, and 2192C>T. The novel TTAT tetr...
Source: Legal Medicine - April 17, 2009 Category: Forensic Medicine Authors: Akiyoshi Tamura, Misa Iwata, Shinya Fukunishi, Hajime Nishio, Koichi Suzuki Tags: Brief Communications Source Type: journals

Evaluation of mRNA-based approach for identification of saliva and semenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Multiplex mRNA profiling by a reverse transcription-polymerase chain reaction (RT-PCR) has been reported in the last few years as a new approach for the identification of body fluids. We have also demonstrated the feasibility of identifying body fluids by using a real-time RT-PCR assay. Statherin (STATH) and histatin (HTN3), the selected genes for saliva, and protamin 2 (PRM2) and semenogelin 1 (SEMG1), those selected for semen, showed high specificity to these body fluids. Thus, the sensitivity and specificity of target genes were examined in body fluid stains. All target genes were detected in 0.1μL 6-day-old ...
Source: Legal Medicine - April 17, 2009 Category: Forensic Medicine Authors: Koichi Sakurada, Hiroshi Ikegaya, Hisayo Fukushima, Tomoko Akutsu, Ken Watanabe, Mineo Yoshino Tags: Brief Communications Source Type: journals

Macrophage subsets in mechanical brain injury (MBI) – A contribution to timing of MBI based on immunohistochemical methods: A pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Cortical hemorrhages as a consequence of closed mechanical brain injury (MBI) trigger an inflammatory response including a distinct increase of macrophages. According to published data this reactive macrophage population is heterogenous as to their immunological properties. The expression of certain immunohistochemically detectable epitopes of macrophages, however, may correlate with the posttraumatic interval (PTI).In a pilot study, 50 selected cases of cortical hemorrhages with 1 min to 1.5 years PTI were examined by light microscopy and macrophages were labeled with CD68-, HLA-D-, HAM-56-, LN-5-, and 25F9-anti...
Source: Legal Medicine - April 17, 2009 Category: Forensic Medicine Authors: M. Oehmichen, S. Jakob, S. Mann, K.S. Saternus, I. Pedal, C. Meissner Tags: Original Article Source Type: journals

Estimation of the time of death based on the assessment of post mortem processes with emphasis on body coolingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: This paper presents a review of the literature referring to the estimation of the time of death (TOD) over nearly 200 years. Emphasis is put on the development of the methods taking advantage of the decrease in body temperature after death, measured in various body sites. The review is complemented by the first authors’ own experiences on TOD estimation based on post mortem temperature measurements in the eyeball and orbit soft tissues. (Source: Legal Medicine)
Source: Legal Medicine - April 17, 2009 Category: Forensic Medicine Authors: Michał Kaliszan, Roman Hauser, Gerhard Kernbach-Wighton Tags: Review Articles Source Type: journals

History of forensic medicine in TurkeyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Turkey has a short history of forensic medicine compared to the developed countries. Sultan Mahmud II established the first medical school of the Ottoman Empire named as Mekteb-i Tıbbiye-i Şahane to provide health services to the army in 1839 [Gok S. Tomorrow, today and yesterday of the forensic medicine. 1st ed. Istanbul: Temel printing office; 1995]. It is also accepted as an important milestone of both medical education and forensic medicine in Turkey [Gok S and Ozen C. History and organization of forensic. 1st ed. Istanbul: Istanbul University Cerrahpasa Medical School Publications; 1982]. The first lecture...
Source: Legal Medicine - April 17, 2009 Category: Forensic Medicine Authors: Polat Oguz, Uysal Cem Tags: Review Articles Source Type: journals

Editorial boardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Legal Medicine)
Source: Legal Medicine - April 17, 2009 Category: Forensic Medicine Source Type: journals

Genetic variation of 15 autosomal short tandem repeat (STR) loci in the Palestinian population of Gaza StripEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Fifteen autosomal STR loci included in the PowerPlex®16 System were typed in a population sample of 125 unrelated individuals from Palestinian population of Gaza Strip. Allele frequencies, Hardy–Weinberg equilibrium and forensic parameters were determined for the following loci: Penta E, D18S51, D21S11, TH01, D3S1358, FGA, TPOX, D8S1179, vWA, Penta D, CSF1PO, D16S539, D7S820, D13S317 and D5S818. (Source: Legal Medicine)
Source: Legal Medicine - April 12, 2009 Category: Forensic Medicine Authors: Masood S.H. Abu Halima, Lennie Pineda Bernal, Fadel A. Sharif Tags: Announcements of Population Data Source Type: journals

Population genetic data for 11 STR loci, including SE33, in Southern BrazilEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Allele frequencies for 11 STR autosomal loci (D3S1358, vWA, D16S539, D2S1338, D8S1179, SE33, D19S433, TH01, FGA, D21S11, D18S51) were analysed in unrelated individuals undergoing paternity testing in Rio Grande do Sul State, Southern Brazil. The most polimorphic locus was SE33. The distributions of the genotypes in the evaluated loci are in Hardy-Weinberg equilibrium after Bonferroni’s correction. (Source: Legal Medicine)
Source: Legal Medicine - April 12, 2009 Category: Forensic Medicine Authors: Rodrigo Rodenbusch, Simone Schumacher, André Zoratto Gastaldo, Fernanda Goulart Lanes Chula, Lila Partichelli Maciel, Tarciana Grandi, Candice Tosi Michelon, Cíntia Costi, Cláudia Maria Dornelles da Silva Tags: Announcements of Population Data Source Type: journals

An autopsy case of severe pleuritis induced by misinsertion of a nasogastric nourishment tube: Diagnostic significance of multinucleated giant cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: An 87-year-old female who had been hospitalized due to pneumonia was administered nourishment through a nasogastric tube. She collapsed as a result of dyspnea after the insertion of a new tube and administration of nourishment. Chest X-rays revealed that the tube was inserted into the left pleural cavity passing the trachea and left bronchi and that the nourishment pooled. In spite of immediate treatment including removal of the tube and insertion of a drain, she died 12 days later. Autopsy findings: Both the left pulmonary and parietal pleurae were thickened and covered with a dirty gray-yellowish moss-like past...
Source: Legal Medicine - April 12, 2009 Category: Forensic Medicine Authors: Akiko Ishigami, Shin-ichi Kubo, Itsuo Tokunaga, Takako Gotohda, Akiyoshi Nishimura Tags: Case Report Source Type: journals

Increase in Dual specificity phosphatase 1, TGF-beta stimulated gene 22, domain family protein 3 and Luc7 homolog (S. cerevisiae)-like messenger RNA after mechanical asphyxiation in the mouse lungEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We investigated the transcriptome profile of mechanical asphyxia and decapitation at 60min after death using serial analysis of gene expression. After comparing the results, 11 genes were significantly increased by the mechanical asphyxia treatment in the mouse lung. Of those genes, quantitative real-time PCR revealed that Dual specificity phosphatase 1 (Dusp1), TGF-beta stimulated gene 22, domain family protein 3 (TSC22d3) and Luc7 homolog (Saccharomyces cerevisiae)-like (Luc7l) after asphyxia were more significantly increased than those after decapitation. Dusp1 inactivated mitogen activated protein kinase, whi...
Source: Legal Medicine - April 12, 2009 Category: Forensic Medicine Authors: Hiroyuki Takahashi, Kazuya Ikematsu, Ryouichi Tsuda, Ichiro Nakasono Tags: Original Articles Source Type: journals

Measurement of force to obstruct the cervical arteries and distribution of tension exerted on a ligature in hangingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We experienced suicidal hanging cases without a ligature in front of the neck. We conducted several anatomical autopsies and the magnetic resonance imaging (MRI), and studied the dynamics behind hanging by applying an apparatus to cadaver and creating a dummy.MRI revealed that the vertebral artery protrudes diagonally upward from the second vertebra to the first one. We also found that this area was not covered with any bony tissue. The average length between the first and second transverse processes was 2cm. We measured the minimum required force to obstruct the blood stream in both carotid and vertebral arterie...
Source: Legal Medicine - April 12, 2009 Category: Forensic Medicine Authors: Shigeru Yamasaki, Izumi Takase, Naoki Takada, Katsuji Nishi Tags: Original Articles Source Type: journals