Legionnaires' DiseaseThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you your search results in order of date.

Pages: 1 2 3 4 5 6 7 8 9 10 11

549 records returned

A combined molecular typing approach does not discriminate Legionella pneumophila serogroup 1 strains of a predominant sequence-based type in Palermo, ItalyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, extended sequence-based typing and pulsed field gel electrophoresis were used in a combined approach in the aim to enhance discriminatory power of the molecular typing procedures. However, probably due to a common environmental reservoir and genetic stability, most of the strains circulating in the geographic area under study belong to the same clone and are, consequently, indistinguishable by molecular typing. Investigations of clinical cases and tracing to their environmental source require caution and support from sound epidemiological data. (Source: Journal of Infection and Public Health)
Source: Journal of Infection and Public Health - November 19, 2009 Category: Global & Universal Authors: Celestino Bonura, Caterina Mammina, Antonietta Vella, Santina Belfiore, Alfredo Chiarini, Anna Giammanco Tags: Original Articles Source Type: journals

Methylprednisolone: Pneumonia caused by Legionella feeleii in an elderly patient?: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 31, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Interferons Direct an Effective Innate Response to Legionella pneumophila Infection [Mechanisms Of Signal Transduction]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Legionella pneumophila remains an important opportunistic pathogen of human macrophages. Its more limited ability to replicate in murine macrophages has been attributed to redundant innate sensor systems that detect and effectively respond to this infection. The current studies evaluate the role of one of these innate response systems, the type I interferon (IFN-I) autocrine loop. The ability of L. pneumophila to induce IFN-I expression was found to be dependent on IRF-3, but not NF-B. Secreted IFN-Is then in turn suppress the intracellular replication of L. pneumophila. Surprisingly, this suppression is mediated by a path...
Source: Journal of Biological Chemistry - October 23, 2009 Category: Chemistry Authors: Plumlee, C. R., Lee, C., Beg, A. A., Decker, T., Shuman, H. A., Schindler, C. Tags: Mechanisms Of Signal Transduction Source Type: journals

Adverse events and efficacy of TNF-{alpha} blockade with infliximab in patients with systemic lupus erythematosus: long-term follow-up of 13 patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Short-term therapy with four infusions of infliximab in combination with AZA was relatively safe, and had remarkable long-term efficacy for lupus nephritis and, potentially, also interstitial lung disease. Long-term therapy with infliximab, however, was associated with severe adverse events in two out of three SLE patients, which may have been provoked by infliximab and/or by their long-standing refractory SLE and previous therapies. (Source: Rheumatology)
Source: Rheumatology - October 16, 2009 Category: Rheumatology Authors: Aringer, M., Houssiau, F., Gordon, C., Graninger, W. B., Voll, R. E., Rath, E., Steiner, G., Smolen, J. S. Tags: Pharmacology, Systemic Lupus Erythematosus and Autoimmunity CLINICAL Source Type: journals

Legionnaires disease cluster linked to a metal product aqueous pre-treatment process, Staffordshire, England, May 2008.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In May 2008, a report of two workers from the same construction equipment manufacturing plant who were admitted to hospital with Legionnaires disease confirmed by urine antigen prompted an outbreak investigation. Both cases were middle aged men, smokers, and with no travel, leisure or other common community exposure to Legionella sources. There were no wet cooling towers at the plant or in the surrounding area. No increase in respiratory disease or worker absenteeism occurred at the plant during the preceding month. Wider case ascertainment including alerts to hospitals and medical practitioners yielded no further case...
Source: Euro Surveill - October 15, 2009 Category: Infectious Diseases Authors: Coetzee N, Liu W, Astbury N, Williams P, Robinson S, Afza M, Duggal H Tags: Euro Surveill Source Type: journals

Cellular pharmacokinetics and intracellular activity of torezolid (TR-700): studies with human macrophage (THP-1) and endothelial (HUVEC) cell linesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Torezolid exerts intracellular activity at lower extracellular concentrations than linezolid because of its greater potency independent of its greater intracellular accumulation. This may confer an advantage to torezolid in vivo if the drug can be used at dosages creating serum concentrations similar to those achieved with linezolid. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - October 12, 2009 Category: Microbiology Authors: Lemaire, S., Van Bambeke, F., Appelbaum, P. C., Tulkens, P. M. Tags: Original research Source Type: journals

Liverpool Hospital Fined Over Legionella, UKEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Health and Safety Executive (HSE) has issued a strong health warning after high levels of the legionella bacteria were found at a Liverpool hospital. The Liverpool Heart and Chest Hospital NHS Trust was ordered to pay nearly Â£48,000 following an HSE investigation at the NHS Trust's hospital on Thomas Drive, Liverpool. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 11, 2009 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Trust accused of 'complacency' over legionella outbreakEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A hospital trust in Liverpool has been forced to pay £48,000 after unsafe levels of legionella bacteria were found in its bathing water supply. (Source: Nursing Times Breaking News)
Source: Nursing Times Breaking News - October 9, 2009 Category: Nursing Source Type: news

Health and Safety Executive slates trust's "complacency" over water supply legionellaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A hospital trust in Liverpool has been forced to pay £48,000 after unsafe levels of legionella bacteria were found in its bathing water supply. (Source: HSJ)
Source: HSJ - October 9, 2009 Category: UK Health Source Type: info

Health and Safety Executive slates trust's 'complacency' over water supply legionellaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A hospital trust in Liverpool has been forced to pay £48,000 after unsafe levels of legionella bacteria were found in its bathing water supply. (Source: HSJ)
Source: HSJ - October 9, 2009 Category: UK Health Source Type: info

Legionnaires' disease cluster linked to a metal product aqueous pre-treatment process, Staffordshire, England, May 2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In May 2008, a report of two workers from the same construction equipment manufacturing plant who were admitted to hospital with Legionnaires' disease confirmed by urine antigen prompted an outbreak investigation. Both cases were middle aged men, smokers, and with no travel, leisure or other common community exposure to Legionella sources. There were no wet cooling towers at the plant or in the surrounding area. No increase in respiratory disease or worker absenteeism occurred at the plant during the preceding month. Wider case ascertainment including alerts to hospitals and medical practitioners yielded no further cases. ...
Source: Eurosurveillance latest news - October 8, 2009 Category: Infectious Diseases Source Type: journals

Role of 'atypical pathogens' among adult hospitalized patients with community-acquired pneumoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examined the role of these 'atypical pathogens' (AP) among adult hospitalized patients with CAP.Methods: A prospective, observational study of consecutive adult CAP (clinico-radiological diagnosis) patients hospitalized during 2004[ndash]2005 was conducted. Causal organisms were determined using cultures, antigen testing and paired serology. Clinical/laboratory/radiological variables and outcomes were compared between different aetiologies, and a clinical prediction rule for AP was constructed.Results: There were 1193 patients studied (mean age 70.8 ± 18.0 years, men 59.3%). Causal organisms were identified i...
Source: Respirology - October 7, 2009 Category: Respiratory Medicine Authors: Grace LUI, Margaret IP, Nelson LEE, Timothy H. RAINER, Shin Y. MAN, Clive S. COCKRAM, Gregory E. ANTONIO, Margaret H.L. NG, Michael H.M. CHAN, Shirley S.L. CHAU, Paulina MAK, Paul K.S. CHAN, Anil T. AHUJA, Joseph J.Y. SUNG, David S.C. HUI Source Type: journals

The metal efflux island of Legionella pneumophila is not required for survival in macrophages and amoebasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Legionella pneumophila is an intracellular pathogen causing pneumonia-like disease in humans. A 43-kb putative heavy metal efflux gene island was found on the L. pneumophila genome. Large Legionella deletion strains of the metal efflux genes were tested in human THP-1-derived macrophages and amoebal Acanthamoeba castellanii cells and were able to survive and replicate similar to the wild type, suggesting that they do not play a significant role within the intracellular environment. Examination of the sequence of this genomic island revealed that some genes were not accurately annotated and there were no known metal-respons...
Source: FEMS Microbiology Letters - October 7, 2009 Category: Microbiology Authors: Eun-Hae Kim, Xavier Charpentier, Oscar Torres-Urquidy, Megan M. McEvoy, Christopher Rensing Source Type: journals

Detergent-like activity and alpha-helical structure of warnericin RK, an anti-legionella peptide.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we aimed to understand the mode of action of warnericin RK and to explain its particular target specificity. We found that warnericin RK permeabilizes artificial membranes in a voltage-independent manner. Osmotic protection experiments on erythrocytes showed that warnericin RK does not form well-defined pores, suggesting a detergent-like mode of action, as previously described for delta-lysin at high concentrations. Warnericin RK also permeabilized Legionella cells, and these cells displayed a high sensitivity to detergents. Depending on the detergent used, Legionella was from 10- to 1000-fold more sensitive ...
Source: Biophysical Journal - October 6, 2009 Category: Physics Authors: Verdon J, Falge M, Maier E, Bruhn H, Steinert M, Faber C, Benz R, Héchard Y Tags: Biophys J Source Type: journals

Legionella in industrial cooling towers: monitoring and control strategiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: For effective decontamination of outdoor industrial cooling towers, disinfectants should be distributed in a targeted way, taking into account the possible sources of contamination.Significance and Impact of the Study: The data of the research permitted to modify the procedure of disinfection for better reduce the water and aerosol contamination and consequently the exposure risk. (Source: Letters in Applied Microbiology)
Source: Letters in Applied Microbiology - October 6, 2009 Category: Microbiology Authors: A. Carducci, M. Verani, R. Battistini Source Type: journals

Evaluation of Legionella pneumophila contamination in Italian hotel water systems by quantitative real-time PCR and culture methodsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study showed a high percentage of buildings colonized by Leg. pneumophila. Moreover, real-time PCR proved to be sensitive enough to detect lower levels of contamination than the culture method.Significance and Impact of the Study: This study indicates that the Italian hotels represent a possible source of risk for Legionnaires' disease and confirms the sensitivity of the molecular method. To our knowledge, this is the first report to demonstrate Legionella contamination in Italian hotels using real-time PCR and culture methods. (Source: Journal of Applied Microbiology)
Source: Journal of Applied Microbiology - September 30, 2009 Category: Microbiology Authors: Sa. Bonetta, Si. Bonetta, E. Ferretti, F. Balocco, E. Carraro Source Type: journals

The Chest Radiographic Manifestations of Legionnaires' Disease in Taiwan: A Retrospective StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objective: To evaluate the chest radiographic manifestations of Legionnaires' disease in Taiwan. Materials and Methods: From January 2003 to August 2008, we reviewed the chest X-rays of 53 patients from a medical center in east Taiwan with a ...more (Source: Tzu Chi Medical Journal)
Source: Tzu Chi Medical Journal - September 30, 2009 Category: Universities & Medical Training Source Type: journals

Non-invasive positive pressure ventilation for a severe legionella pneumonia case.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Legionella pneumonia has a serious clinical course and requires treatment at intensive care unit. The need for mechanical ventilation is one of the determinants of prognosis. Mortality rate is higher in patients treated with mechanical ventilation. Non-invasive positive pressure ventilation (NPPV) provides mechanical ventilation without endotracheal intubation and decreases the incidence of ventilator associated pneumonia. It is a treatment modality for patients with hypoxia due to community acquired pneumonia. The present case was admitted to intensive care unit with a diagnosis of legionella pneumonia, and his hypoxe...
Source: Tuberkuloz ve Toraks - September 30, 2009 Category: Respiratory Medicine Authors: Eryüksel E, Karakurt S, Balci M, Celikel T Tags: Tuberk Toraks Source Type: journals

Phospholipase PlaB of Legionella pneumophila Represents a Novel Lipase Family: PROTEIN RESIDUES ESSENTIAL FOR LIPOLYTIC ACTIVITY, SUBSTRATE SPECIFICITY, AND HEMOLYSIS [Enzyme Catalysis and Regulation]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Legionella pneumophila possesses several phospholipases capable of host cell manipulation and lung damage. Recently, we discovered that the major cell-associated hemolytic phospholipase A (PlaB) shares no homology to described phospholipases and is dispensable for intracellular replication in vitro. Nevertheless, here we show that PlaB is the major lipolytic activity in L. pneumophila cell infections and that PlaB utilizes a typical catalytic triad of Ser-Asp-His for effective hydrolysis of phospholipid substrates. Crucial residues were found to be located within the N-terminal half of the protein, and amino acids embeddin...
Source: Journal of Biological Chemistry - September 24, 2009 Category: Chemistry Authors: Bender, J., Rydzewski, K., Broich, M., Schunder, E., Heuner, K., Flieger, A. Tags: Enzyme Catalysis and Regulation Source Type: journals

Legionella pneumophila secretes an endoglucanase that belongs to the family-5 of glycosyl hydrolases and is dependent upon type II secretionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Examination of cell-free culture supernatants revealed that Legionella pneumophila strains secrete an endoglucanase activity. Legionella pneumophila lspF mutants were deficient for this activity, indicating that the endoglucanase is secreted by the bacterium's type II protein secretion (T2S) system. Inactivation of celA, encoding a member of the family-5 of glycosyl hydrolases, abolished the endoglucanase activity in L. pneumophila culture supernatants. The cloned celA gene conferred activity upon recombinant Escherichia coli. Thus, CelA is the major secreted endoglucanase of L. pneumophila. Mutants inactivated for celA gr...
Source: FEMS Microbiology Letters - September 20, 2009 Category: Microbiology Authors: Meghan M. Pearce, Nicholas P. Cianciotto Source Type: journals

Mediators of Lipid A Modification, RNA Degradation, and Central Intermediary Metabolism Facilitate the Growth of Legionella pneumophila at Low Temperatures.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Legionella pneumophila is an aquatic bacterium that is also the agent of Legionnaires' disease pneumonia. Since L. pneumophila is transmitted directly from the environment to the lung, it is important to understand how legionellae survive at low temperatures. To identify genes that are needed for L. pneumophila growth at low temperature, we screened a population of mutagenized legionellae for strains that are specifically impaired for growth at 17 degrees C. From the 7,400 mutants tested, 11 displayed defects ranging from ca. 10-fold to a complete inability to grow at the low temperature. PCR and sequence analysis were...
Source: Current Microbiology - September 18, 2009 Category: Microbiology Authors: Söderberg MA, Cianciotto NP Tags: Curr Microbiol Source Type: journals

The Amoebal MAP Kinase Response to Legionella pneumophila Is Regulated by DupA.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The amoeba Dictyostelium discoideum can support replication of Legionella pneumophila. Here we identify the dupA gene, encoding a putative tyrosine kinase/dual-specificity phosphatase, in a screen for D. discoideum mutants altered in allowing L. pneumophila intracellular replication. Inactivation of dupA resulted in depressed L. pneumophila growth and sustained hyperphosphorylation of the amoebal MAP kinase ERK1, consistent with loss of a phosphatase activity. Bacterial challenge of wild-type amoebae induced dupA expression and resulted in transiently increased ERK1 phosphorylation, suggesting that dupA and ERK1 are pa...
Source: Cell Host and Microbe - September 16, 2009 Category: Microbiology Authors: Li Z, Dugan AS, Bloomfield G, Skelton J, Ivens A, Losick V, Isberg RR Tags: Cell Host Microbe Source Type: journals

Shower heads and lung diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Daily Telegraph today reported that a “daily shower could be hazardous”. It said that US researchers have found that shower heads are “breeding grounds for bacteria and when water is passed through them, they blast out the bugs”. One of the main microbes identified was Mycobacterium avium, which can cause respiratory infections mainly in people with a weak immune system or chronic respiratory disease. This small study looked at the microbes in 45 shower heads from nine cities in the US. Although it did find the presence of mycobacteria and other bacteria, it did not look at whether using a shower actually incre...
Source: NHS News Feed - September 15, 2009 Category: Consumer Health News Tags: Heart/lungs Source Type: news

First isolation of Legionella species, including L. pneumophila serogroup 1, in Greek potting soils: possible importance for public healthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clin Microbiol Infect A total of 21 Legionella isolates were recovered from six out of 22 samples of potting soil from the Athens area, Greece. Legionella pneumophila (serogroups 1 and 2[ndash]15) and species and serotypes included in the group of L. longbeachae serogroups 1 and 2, L. bozemanii serogroups 1 and 2, L. dumoffii, L. gormanii, L. jordanis, L. micdadei and L. anisa were isolated on BCYE[alpha] agar containing cysteine, GVPC and natamycin and on BCYE[alpha] agar containing cysteine, Wadowsky Yee supplement and natamycin. The bacterial load was 4000[ndash]120 000 CFU/g of potting soil. The isolation of L. pneumop...
Source: Clinical Microbiology and Infection - September 11, 2009 Category: Microbiology Authors: E. N. Velonakis, I. M. Kiousi, C. Koutis, E. Papadogiannakis, F. Babatsikou, A. Vatopoulos Source Type: journals

Innate immune response during Yersinia infection: critical modulation of cell death mechanisms through phagocyte activation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Yersinia pestis, the etiological agent of plague, is one of the most deadly pathogens on our planet. This organism shares important attributes with its ancestral progenitor, Yersinia pseudotuberculosis, including a 70-kb virulence plasmid, lymphotropism during growth in the mammalian host and killing of host macrophages. Infections with both organisms are biphasic, where bacterial replication occurs initially with little inflammation, followed by phagocyte influx, inflammatory cytokine production, and tissue necrosis. During infection, plasmid-encoded attributes facilitate bacterial-induced macrophage death, which resu...
Source: Journal of Leukocyte Biology - September 3, 2009 Category: Hematology Authors: Bergsbaken T, Cookson BT Tags: J Leukoc Biol Source Type: journals

Survivors Oppose Motion To Dismiss Wrongful Death, Premises Liability LawsuitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SAN DIEGO - The survivors of a man killed by Legionella virus who allege that Harrah's Entertainment Inc. is liable for his death and the company were granted a joint motion to reset an Aug. 14 hearing on the motion to dismiss to Sept. 11 in the U.S. District Court for the Southern District of California (Rachel Almazan, et al. v. Harrah's Entertainment Inc., No. 09-1189, S.D. Calif.; See 7/7/09, Page 22). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News)
Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News - September 2, 2009 Category: Medical Law Source Type: info

Many substrates and functions of type II secretion: lessons learned from Legionella pneumophilaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Future Microbiology , September 2009, Vol. 4, No. 7, Pages 797-805. (Source: Future Microbiology)
Source: Future Microbiology - September 1, 2009 Category: Cardiology Tags: article Source Type: journals

Diagnostic and typing methods for investigating Legionella infection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Legionella infection is an important cause of community-acquired pneumonia in Australia. Morbidity and mortality is significant. Diagnosis remains a challenge with infection often unrecognised, particularly early in the course of illness. An understanding of available diagnostic methods and their limitations is important to public health practitioners and clinicians alike. PMID: 19917208 [PubMed - in process] (Source: New South Wales Public Health Bulletin)
Source: New South Wales Public Health Bulletin - September 1, 2009 Category: Health Management Authors: Blyth CC, Adams DN, Chen SC Tags: N S W Public Health Bull Source Type: journals

Evidence for PracticeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Infection with Legionella, a gram-negative bacterium, can cause either pneumonia due to Legionnaires disease or Pontiac fever, a milder, influenza-like disease. There are 50 species and at least 64 serogroups in the Legionellaceae family, and Legionella pneumophila serogroup 1 is implicated in the majority of human cases of Legionella infection. The most frequent mechanism of transmission in humans is by inhalation of aerosols from contaminated water; this water might come from condensers, showers, cooling towers, humidifiers, whirlpool spas, decorative fountains, or residential water sources. (Source: AORN Journal)
Source: AORN Journal - August 31, 2009 Category: Nursing Authors: George Allen Tags: Departments Source Type: journals

Detection of IgM Antibodies against Legionella pneumophila Serogroup 1 in Malaysian Blood Donors and Patients with Respiratory Illnesses: Evaluation of Enzyme-Linked Immunosorbent Assay and Indirect Immunofluorescence Assay.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19762997 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - August 31, 2009 Category: Infectious Diseases Authors: Tay ST, Lakhbeer Singh HK, Ramasame SD, Vadivelu J Tags: Jpn J Infect Dis Source Type: journals

Development of a pilot-scale 1 for Legionella elimination in biofilm in hot water network: heat shock treatment evaluationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Thermal disinfection does not seem to be efficient enough to eliminate Legionella when it is used as a curative treatment.Significance and Impact of the Study: This work could help water managers for a better management of water network and for a better control of Legionella. (Source: Journal of Applied Microbiology)
Source: Journal of Applied Microbiology - August 27, 2009 Category: Microbiology Authors: M. Farhat, M.-C. Trouilhé, E. Briand, M. Moletta-Denat, E. Robine, J. Frère Source Type: journals

Legionella pneumophila - Host Interactions: Insights Gained from Comparative Genomics and Cell Biology.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Legionella pneumophila is the etiological agent of Legionnaires' disease and of the less acute disease Pontiac fever. It is a Gram-negative bacterium present in fresh and artificial water environments that replicates in protozoan hosts and is also found in biofilms. Replication within protozoa is essential for the survival of the bacterium. The last years have seen a giant step forward in the genomics of L. pneumophila. The establishment and publication of the complete genome sequences of three clinical L. pneumophila isolates in 2004 and a fourth in 2007 has paved the way for major breakthroughs in understanding the b...
Source: Genome Dynamics - August 23, 2009 Category: Genetics & Stem Cells Authors: Lomma M, Valero G, Rusniok C, Buchrieser C Tags: Genome Dyn Source Type: journals

Detective's wife dies from Legionnaire's disease after being misdiagnosed with swine fluEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A detective's wife died in "terrible circumstances" from sepsis due to Legionnaire's disease after she was misdiagnosed with Swine Flu. (Source: The Telegraph : Swine Flu A H1N1)
Source: The Telegraph : Swine Flu A H1N1 - August 20, 2009 Category: Infectious Diseases Tags: kevin rowe carol rowe thames valley detective south central ambulance swine flu Source Type: news

Company Fined For Inadequate Legionella Assessments At Welsh Care HomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Health and Safety Executive (HSE) is warning companies responsible for carrying out legionella surveys on water systems of the need to ensure that their work is thorough and accurate. The warning follows the conviction of a Berkshire-based water treatment company for carrying out inadequate and misleading surveys at nursing homes in Blaenau Gwent and Powys. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 20, 2009 Category: Consumer Health News Tags: Water - Air Quality / Agriculture Source Type: news

A Legionella type IV effector activates the NF-{kappa}B pathway by phosphorylating the I{kappa}B family of inhibitors [Biochemistry]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NF-B is critical in innate immune defense responses against invading microbial pathogens. Legionella pneumophila infection of lung macrophages causes Legionnaire's... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 17, 2009 Category: Science Authors: Ge, J., Xu, H., Li, T., Zhou, Y., Zhang, Z., Li, S., Liu, L., Shao, F. Tags: Biochemistry Source Type: journals

Legionella Cases Linked to Nonsterile Ice for Bronchoalveolar LavageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of nonsterile ice to cool saline syringes for bronchoalveolar lavage appears to be the cause of a pseudo-outbreak of Legionnaire's disease that occurred last year in Arizona, according to findings in the Morbidity and Mortality Weekly Report for August 14. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 17, 2009 Category: Consumer Health News Tags: Infectious Diseases Source Type: news

Pseudo-Outbreak of Legionnaires Disease Among Patients Undergoing Bronchoscopy --- Arizona, 2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - August 14, 2009 Category: American Health Source Type: organizations

Legionnaires caused by unsterilized iceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ATLANTA, Aug. 14 (UPI) -- Four patients at an Arizona hospital were incorrectly diagnosed with Legionnaires' disease last year because of un-sterilized ice, health officials said. (Source: Health News - UPI.com)
Source: Health News - UPI.com - August 14, 2009 Category: Consumer Health News Source Type: news

Pseudo-outbreak of legionnaires disease among patients undergoing bronchoscopy - Arizona, 2008.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report summarizes the results of that investigation, which determined that the patients did not have LD and that nonsterile ice used to cool saline-filled syringes for bronchoalveolar lavage was the likely source of Legionella contamination of these clinical specimens. Ice was supplied by two ice machines, which became contaminated by heavy Legionella colonization within the center's potable water supply during a 6-month period (February--July 2008). Findings from the investigation underscore the importance of adherence to recommended infection control practices and surveillance for LD in health-care settings. Clinici...
Source: MMWR Morb Mortal Wkl... - August 13, 2009 Category: Epidemiology Tags: MMWR Morb Mortal Wkly Rep Source Type: journals

Pseudo-Outbreak of Legionnaire's Blamed on Bad IceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Using nonsterile ice to cool saline-filled syringes for bronchoalveolar lavage creates a risk of Legionnaire’s disease, the CDC said. (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - August 13, 2009 Category: Infectious Diseases Source Type: news

Kent hospitals confirm new Legionnaires' disease casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Investigations are continuing after further cases of Legionnaires’ disease were confirmed at an NHS trust in east Kent. (Source: Nursing Times Breaking News)
Source: Nursing Times Breaking News - August 13, 2009 Category: Nursing Source Type: news

New Legionnaires' cases investigatedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
TWO new cases of Legionnaires' disease are being investigated at a hospital where a man died and two women are seriously ill, officials said yesterday. (Source: Scotsman.com News - Health)
Source: Scotsman.com News - Health - August 12, 2009 Category: Consumer Health News Source Type: news

Legionnaires' disease strikes Kent hospitalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Swift action by NHS staff at the William Harvey Hospital in Ashford, Kent, has limited the spread of Legionnaires’ disease after it was contracted by an elderly patient. (Source: Nursing Times Breaking News)
Source: Nursing Times Breaking News - August 11, 2009 Category: Nursing Source Type: news

Aetiology of, and risk factors for, recurrent community-acquired pneumoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clin Microbiol Infect Recurrent community-acquired pneumonia (CAP) requiring hospitalization is a matter of particular concern. However, current information on its prevalence, aetiology and risk factors is lacking. To address these issues, we performed an observational analysis of a prospective cohort of hospitalized adults with CAP. Recurrence was defined as two or more episodes of CAP 1 month apart within 3 years. Patients with severe immunosuppression or local predisposing factors were excluded. Of the 1556 patients, 146 (9.4%) had recurrent CAP. The most frequent causative organism was Streptococcus pneumoniae, both in...
Source: Clinical Microbiology and Infection - August 9, 2009 Category: Microbiology Authors: C. Garcia-Vidal, J. Carratalà, N. Fernández-Sabé, J. Dorca, R. Verdaguer, F. Manresa, F. Gudiol Source Type: journals

Molecular mimicry: an important virulence strategy employed by Legionella pneumophila to subvert host functionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Future Microbiology , August 2009, Vol. 4, No. 6, Pages 691-701. (Source: Future Microbiology)
Source: Future Microbiology - August 6, 2009 Category: Cardiology Tags: article Source Type: journals

Health Warning After Lancashire Workers Catch Legionnaires' Disease, UKEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Health and Safety Executive (HSE) has warned companies in Lancashire to ensure they carry out regular, simple checks to protect employees from Legionnaires' disease. The warning follows the prosecution of butchery processing company Kepak UK Ltd after two employees caught the disease at Kepak's Carr Place premises on the Walton Summit Industrial Estate, Bamber Bridge, Preston. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 2, 2009 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

[Evaluation of Seeplex(TM) Pneumobacter Multiplex PCR Kit for the Detection of Respiratory Bacterial Pathogens in Pediatric Patients.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Seeplex(TM) Pneumobacter detection kit could be a useful screening tool for the rapid detection of respiratory bacterial pathogens. Further studies with lower respiratory tract specimens would be needed for the clinical evaluation of S. pneumoniae and H. influenzae detected by multiplex PCR. PMID: 19726892 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine)
Source: The Korean Journal of Laboratory Medicine - July 31, 2009 Category: Laboratory Medicine Authors: Park J, Kim JK, Rheem I, Kim J Tags: Korean J Lab Med Source Type: journals

Legionella pneumophila in rainwater on roads.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
During rain, transient puddles form on roads, and this water is splashed into the air by moving vehicles. To determine whether this water contains Legionella pneumophila, we collected samples from roads. We found that L. pneumophila are abundant in these puddles, especially during warm weather. PMID: 19751596 [PubMed - in process] (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - July 31, 2009 Category: Infectious Diseases Authors: Sakamoto R, Ohno A, Nakahara T, Satomura K, Iwanaga S, Kouyama Y, Kura F, Kato N, Matsubayashi K, Okumiya K, Yamaguchi K Tags: Emerg Infect Dis Source Type: journals

LegionellaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Venue: SCI International Headquarters Start date: Wed, 16 Sep 2009 17:00:00 +0100 End date: Wed, 16 Sep 2009 20:00:00 +0100 (Source: Nature Network London - Recent News)
Source: Nature Network London - Recent News - July 29, 2009 Category: Science Source Type: events

Bacterial toxin and effector glycosyltransferases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clostridial glucosylating cytotoxins, including Clostridium difficile toxins A and B, Clostridium novyi alpha-toxin, and Clostridium sordellii lethal toxin, are major virulence factors and causative agents of human diseases. These toxins mono-O-glucosylate (or mono-O-GlcNAcylate) a specific threonine residue of Rho/Ras-proteins, which is essential for the function of the molecular switches. Recently, a related group of glucosyltransferases from Legionella pneumophila has been identified. These Legionella glucosyltransferases modify the large GTPase elongation factor eEF1A at a serine residue by mono-O-glucosylation, th...
Source: Biochimica et Biophysica Acta - July 28, 2009 Category: Biochemistry Authors: Belyi Y, Aktories K Tags: Biochim Biophys Acta Source Type: journals