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Targeted therapy in T-cell malignancies: dysregulation of the cellular signaling pathwaysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Leukemia advance online publication, October 29, 2009. doi:10.1038/leu.2009.223 Author: W-L Zhao (Source: Leukemia)
Source: Leukemia - October 29, 2009 Category: Hematology Authors: W-L Zhao Source Type: journals

Similar patterns of chromosome abnormalities in CML occur in addition to the Philadelphia chromosome with or without tyrosine kinase inhibitor treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& T Haferlach (Source: Leukemia)
Source: Leukemia - October 29, 2009 Category: Hematology Authors: C HaferlachU BacherS SchnittgerT WeissW KernT Haferlach Source Type: journals

PML–RARα ligand-binding domain deletion mutations associated with reduced disease control and outcome after first relapse of APLEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PML–RARα ligand-binding domain deletion mutations associated with reduced disease control and outcome after first relapse of APL Leukemia advance online publication, October 29, 2009. doi:10.1038/leu.2009.220 Authors: E Schachter-Tokarz, C Kelaidi, B Cassinat, C Chomienne, C Gardin, E Raffoux, H Dombret, P Fenaux & R Gallagher (Source: Leukemia)
Source: Leukemia - October 29, 2009 Category: Hematology Authors: E Schachter-TokarzC KelaidiB CassinatC ChomienneC GardinE RaffouxH DombretP FenauxR Gallagher Source Type: journals

Myxoma virus targets primary human leukemic stem and progenitor cells while sparing normal hematopoietic stem and progenitor cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
gle & G McFadden (Source: Leukemia)
Source: Leukemia - October 29, 2009 Category: Hematology Authors: M KimG J MadlambayanM M RahmanS E SmallwoodA M MeachamK HosakaE W ScottC R CogleG McFadden Source Type: journals

Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemiasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
D Birnbaum & M J Mozziconacci (Source: Leukemia)
Source: Leukemia - October 29, 2009 Category: Hematology Authors: N CarbucciaV TrouplinV Gelsi-BoyerA MuratiJ RocquainJ AdélaïdeS OlschwangL XerriN VeyM ChaffanetD BirnbaumM J Mozziconacci Source Type: journals

The JAK2 46/1 haplotype confers susceptibility to essential thrombocythemia regardless of JAK2V617F mutational status—clinical correlates in a study of 226 consecutive patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The JAK2 46/1 haplotype confers susceptibility to essential thrombocythemia regardless of JAK2V617F mutational status—clinical correlates in a study of 226 consecutive patients Leukemia advance online publication, October 22, 2009. doi:10.1038/leu.2009.226 Authors: A Pardanani, T L Lasho, C M Finke, N Gangat, A P Wolanskyj, C A Hanson & A Tefferi (Source: Leukemia)
Source: Leukemia - October 21, 2009 Category: Hematology Authors: A PardananiT L LashoC M FinkeN GangatA P WolanskyjC A HansonA Tefferi Source Type: journals

JAK2 germline genetic variation affects disease susceptibility in primary myelofibrosis regardless of V617F mutational status: nullizygosity for the JAK2 46/1 haplotype is associated with inferior survivalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
JAK2 germline genetic variation affects disease susceptibility in primary myelofibrosis regardless of V617F mutational status: nullizygosity for the JAK2 46/1 haplotype is associated with inferior survival Leukemia advance online publication, October 22, 2009. doi:10.1038/leu.2009.225 Authors: A Tefferi, T L Lasho, M M Patnaik, C M Finke, K Hussein, W J Hogan, M A Elliott, M R Litzow, C A Hanson & A Pardanani (Source: Leukemia)
Source: Leukemia - October 21, 2009 Category: Hematology Authors: A TefferiT L LashoM M PatnaikC M FinkeK HusseinW J HoganM A ElliottM R LitzowC A HansonA Pardanani Source Type: journals

Wilms tumor 1 (WT1) gene mutations in pediatric T-cell malignanciesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
nd, C Preudhomme & H Cavé (Source: Leukemia)
Source: Leukemia - October 21, 2009 Category: Hematology Authors: A RennevilleS KaltenbachE ClappierS ColletteJ-B MicolB NelkenP LepelleyN DastugueY BenoîtY BertrandC PreudhommeH Cavé Source Type: journals

Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ton, T Moritz & D A Williams (Source: Leukemia)
Source: Leukemia - October 21, 2009 Category: Hematology Authors: A Sanchez-AguileraI RattmannD Z DrewL U W MüllerV SummeyD M LucasJ C ByrdC M CroceY GuJ A CancelasP JohnstonT MoritzD A Williams Source Type: journals

The expression levels of the pro-apoptotic XAF-1 gene modulate the cytotoxic response to Nutlin-3 in B chronic lymphocytic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gattei & G Zauli (Source: Leukemia)
Source: Leukemia - October 21, 2009 Category: Hematology Authors: P SecchieroM G di IasioE MelloniR VoltanC CeleghiniM TiribelliM Dal BoV GatteiG Zauli Source Type: journals

Influence of NPM1 and FLT3-ITD status on outcome in relapsed/refractory AML patients receiving salvage therapy including gemtuzumab ozogamicinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Influence of NPM1 and FLT3-ITD status on outcome in relapsed/refractory AML patients receiving salvage therapy including gemtuzumab ozogamicin Leukemia advance online publication, October 22, 2009. doi:10.1038/leu.2009.214 Authors: P Chevallier, T Prebet, A Pigneux, M Hunault, J Delaunay, F Perry, L Lode, S Richebourg, O Blanchet, N Vey, N Ifrah, N Milpied, D Blaise, J-L Harousseau & M Mohty (Source: Leukemia)
Source: Leukemia - October 21, 2009 Category: Hematology Authors: P ChevallierT PrebetA PigneuxM HunaultJ DelaunayF PerryL LodeS RichebourgO BlanchetN VeyN IfrahN MilpiedD BlaiseJ-L HarousseauM Mohty Source Type: journals

Aberrant telomere structure is characteristic of resistant chronic lymphocytic leukaemia cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ilson, M Goodhardt & J Delic (Source: Leukemia)
Source: Leukemia - October 21, 2009 Category: Hematology Authors: T BrugatN GaultI BaccelliJ MaësA Roborel de ClimensF Nguyen-KhacF DaviH Merle-BéralE GilsonM GoodhardtJ Delic Source Type: journals

Negative prognostic impact of PTEN mutation in pediatric T-cell acute lymphoblastic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
lise & J A Yunes (Source: Leukemia)
Source: Leukemia - October 14, 2009 Category: Hematology Authors: P Y JottaM A GanazzaA SilvaM B VianaM J da SilvaL J G ZambaldiJ T BarataS R BrandaliseJ A Yunes Source Type: journals

Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 through Mcl-1/Noxa axisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 through Mcl-1/Noxa axis Leukemia advance online publication, October 15, 2009. doi:10.1038/leu.2009.212 Authors: K Kojima, M Konopleva, T Tsao, M Andreeff, H Ishida, Y Shiotsu, L Jin, Y Tabe & H Nakakuma (Source: Leukemia)
Source: Leukemia - October 14, 2009 Category: Hematology Authors: K KojimaM KonoplevaT TsaoM AndreeffH IshidaY ShiotsuL JinY TabeH Nakakuma Source Type: journals

Novel RUNX1 mutations in familial platelet disorder with enhanced risk for acute myeloid leukemia: clues for improved identification of the FPD/AML syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Novel RUNX1 mutations in familial platelet disorder with enhanced risk for acute myeloid leukemia: clues for improved identification of the FPD/AML syndrome Leukemia advance online publication, October 15, 2009. doi:10.1038/leu.2009.210 Authors: M C J Jongmans, R P Kuiper, C L Carmichael, E J Wilkins, N Dors, A Carmagnac, A Y N Schouten-van Meeteren, X Li, M Stankovic, E Kamping, H Bengtsson, E F P M Schoenmakers, A Geurts van Kessel, P M Hoogerbrugge, C N Hahn, P P Brons, H S Scott & N Hoogerbrugge (Source: Leukemia)
Source: Leukemia - October 14, 2009 Category: Hematology Authors: M C J JongmansR P KuiperC L CarmichaelE J WilkinsN DorsA CarmagnacA Y N Schouten-van MeeterenX LiM StankovicE KampingH BengtssonE F P M SchoenmakersA Geurts van KesselP M HoogerbruggeC N HahnP P BronsH S ScottN Hoogerbrugge Source Type: journals

Single-cell analysis reveals oligoclonality among ‘low-count’ monoclonal B-cell lymphocytosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Single-cell analysis reveals oligoclonality among ‘low-count’ monoclonal B-cell lymphocytosis Leukemia advance online publication, October 15, 2009. doi:10.1038/leu.2009.192 Authors: M C Lanasa, S D Allgood, A D Volkheimer, J P Gockerman, J F Whitesides, B K Goodman, J O Moore, J B Weinberg & M C Levesque (Source: Leukemia)
Source: Leukemia - October 14, 2009 Category: Hematology Authors: M C LanasaS D AllgoodA D VolkheimerJ P GockermanJ F WhitesidesB K GoodmanJ O MooreJ B WeinbergM C Levesque Source Type: journals

Oral fludarabine in untreated patients with B-cell chronic lymphocytic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Li, L Rassenti & T Kipps (Source: Leukemia)
Source: Leukemia - October 7, 2009 Category: Hematology Authors: C ShustikA R TurnerP DesjardinsL FernandezS RubinL LarrattA M V DuncanD RiziA SaduraL ShepherdD LiL RassentiT Kipps Source Type: journals

The synergy of panobinostat plus doxorubicin in acute myeloid leukemia suggests a role for HDAC inhibitors in the control of DNA repairEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
a & J F San-Miguel (Source: Leukemia)
Source: Leukemia - October 7, 2009 Category: Hematology Authors: P MaisoE ColadoE M OcioM GarayoaJ MartínP AtadjaA PandiellaJ F San-Miguel Source Type: journals

In vivo dynamics of human cord blood-derived CD34− SCID-repopulating cells using intra-bone marrow injectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In vivo dynamics of human cord blood-derived CD34− SCID-repopulating cells using intra-bone marrow injection Leukemia advance online publication, October 1, 2009. doi:10.1038/leu.2009.206 Authors: T Kimura, Y Matsuoka, M Murakami, T Kimura, M Takahashi, T Nakamoto, K Yasuda, K Matsui, K Kobayashi, S Imai, H Asano, R Nakatsuka, Y Uemura, Y Sasaki & Y Sonoda (Source: Leukemia)
Source: Leukemia - September 30, 2009 Category: Hematology Authors: T KimuraY MatsuokaM MurakamiT KimuraM TakahashiT NakamotoK YasudaK MatsuiK KobayashiS ImaiH AsanoR NakatsukaY UemuraY SasakiY Sonoda Source Type: journals

Oligomerization inhibition, combined with allosteric inhibition, abrogates the transformation potential of T315I-positive BCR/ABLEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oligomerization inhibition, combined with allosteric inhibition, abrogates the transformation potential of T315I-positive BCR/ABL Leukemia advance online publication, October 1, 2009. doi:10.1038/leu.2009.194 Authors: A A Mian, C Oancea, Z Zhao, O G Ottmann & M Ruthardt (Source: Leukemia)
Source: Leukemia - September 30, 2009 Category: Hematology Authors: A A MianC OanceaZ ZhaoO G OttmannM Ruthardt Source Type: journals

Choosing the best treatment strategy for chronic myeloid leukemia patients resistant to imatinib: weighing the efficacy and safety of individual drugs with BCR-ABL mutations and patient historyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& H M Kantarjian (Source: Leukemia)
Source: Leukemia - September 30, 2009 Category: Hematology Authors: E JabbourA HochhausJ CortesP La RoséeH M Kantarjian Source Type: journals

Stem cell traits in long-term co-culture revealed by time-lapse imagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Y Xie & T Cheng (Source: Leukemia)
Source: Leukemia - September 30, 2009 Category: Hematology Authors: Y SongA BahnsonN HallH YuH ShenD KoeblerR HouckY XieT Cheng Source Type: journals

International Myeloma Working Group molecular classification of multiple myeloma: spotlight reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ny Reiman, Linda Pilarski & H Avet-Loiseau (Source: Leukemia)
Source: Leukemia - September 30, 2009 Category: Hematology Authors: R FonsecaP L BergsagelJ DrachJ ShaughnessyN GutierrezK StewartG MorganB Van NessM ChesiS MinvielleA NeriB BarlogieW M KuehlP LiebischF DaviesS Chen-KiangB G M DurieR CarrascoOrhan SezerTony ReimanLinda PilarskiH Avet-Loiseau Source Type: journals

The TLR1/2 agonist PAM3CSK4 instructs commitment of human hematopoietic stem cells to a myeloid cell fateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The TLR1/2 agonist PAM3CSK4 instructs commitment of human hematopoietic stem cells to a myeloid cell fate Leukemia advance online publication, July 30, 2009. doi:10.1038/leu.2009.155 Authors: K De Luca, V Frances-Duvert, M-J Asensio, R Ihsani, E Debien, M Taillardet, E Verhoeyen, C Bella, S Lantheaume, L Genestier & T Defrance (Source: Leukemia)
Source: Leukemia - July 29, 2009 Category: Hematology Authors: K De LucaV Frances-DuvertM-J AsensioR IhsaniE DebienM TaillardetE VerhoeyenC BellaS LantheaumeL GenestierT Defrance Source Type: journals

Novel epigenetic mechanisms that control pluripotency and quiescence of adult bone marrow-derived Oct4+ very small embryonic-like stem cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Novel epigenetic mechanisms that control pluripotency and quiescence of adult bone marrow-derived Oct4+ very small embryonic-like stem cells Leukemia advance online publication, July 30, 2009. doi:10.1038/leu.2009.153 Authors: D M Shin, E K Zuba-Surma, W Wu, J Ratajczak, M Wysoczynski, M Z Ratajczak & M Kucia (Source: Leukemia)
Source: Leukemia - July 29, 2009 Category: Hematology Authors: D M ShinE K Zuba-SurmaW WuJ RatajczakM WysoczynskiM Z RatajczakM Kucia Source Type: journals

The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Huang & A W Roberts (Source: Leukemia)
Source: Leukemia - July 29, 2009 Category: Hematology Authors: K D MasonS L KhawK C RayerouxE ChewE F LeeW D FairlieA P GriggJ F SeymourJ SzerD C S HuangA W Roberts Source Type: journals

Low-dose subcutaneous alemtuzumab in refractory chronic lymphocytic leukaemia (CLL): results of a prospective, single-arm multicentre studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neri & G L Deliliers (Source: Leukemia)
Source: Leukemia - July 29, 2009 Category: Hematology Authors: A CortelezziM C PasquiniA GardelliniU GianelliA BossiG RedaB SarinaP MustoW BarcelliniA NeriG L Deliliers Source Type: journals

Gene knockdown studies revealed CCDC50 as a candidate gene in mantle cell lymphoma and chronic lymphocytic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
, P Lichter & A Pscherer (Source: Leukemia)
Source: Leukemia - July 29, 2009 Category: Hematology Authors: A FarfsingF EngelM SeiffertE HartmannG OttA RosenwaldS StilgenbauerH DöhnerM BoutrosP LichterA Pscherer Source Type: journals

Chronic myeloproliferative diseases with and without the Ph chromosome: some unresolved issuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
da & A M Vannucchi (Source: Leukemia)
Source: Leukemia - July 29, 2009 Category: Hematology Authors: J M GoldmanA R GreenT HolyoakeC JamiesonR MesaT MughalF PellicanoD PerrottiR SkodaA M Vannucchi Source Type: journals

Standardized MRD flow and ASO IGH RQ-PCR for MRD quantification in CLL patients after rituximab-containing immunochemotherapy: a comparative analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
hner, M Hallek, M Kneba & M Ritgen (Source: Leukemia)
Source: Leukemia - July 29, 2009 Category: Hematology Authors: S BöttcherS StilgenbauerR BuschM BrüggemannT RaffC PottK FischerG Fingerle-RowsonH DöhnerM HallekM KnebaM Ritgen Source Type: journals

B-cell prolymphocytic leukemia and chronic lymphocytic leukemia have distinctive gene expression signaturesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
tovsky & E Matutes (Source: Leukemia)
Source: Leukemia - July 29, 2009 Category: Hematology Authors: I Del GiudiceN OsujiT DexterV Brito-BabapulleN Parry-JonesS ChiarettiM MessinaG MorganD CatovskyE Matutes Source Type: journals

Dasatinib-associated major molecular responses in patients with chronic myeloid leukemia in chronic phase following imatinib failure: response dynamics and predictive valueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
dt, A Lambert & T P Hughes (Source: Leukemia)
Source: Leukemia - July 29, 2009 Category: Hematology Authors: A HochhausM C MüllerJ RadichS BranfordH M KantarjianB HanfsteinP RousselotD-W KimJ H LiptonE BleickardtA LambertT P Hughes Source Type: journals

Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Kitamura & T Nosaka (Source: Leukemia)
Source: Leukemia - July 26, 2009 Category: Hematology Authors: R OnoH KumagaiH NakajimaA HishiyaT TakiK HorikawaK TakatsuT SatohY HayashiT KitamuraT Nosaka Source Type: journals

Antileukemic activity of valproic acid in chronic lymphocytic leukemia B cells defined by microarray analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& L Lagneaux (Source: Leukemia)
Source: Leukemia - July 26, 2009 Category: Hematology Authors: B StamatopoulosN MeulemanC De BruynP MineurP MartiatD BronL Lagneaux Source Type: journals

Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
izaki & S Kamihira (Source: Leukemia)
Source: Leukemia - July 26, 2009 Category: Hematology Authors: H HasegawaY YamadaH IhaK TsukasakiK NagaiS AtogamiK SugaharaK TsurudaA IshizakiS Kamihira Source Type: journals

Characterizing chromosomal break points of t(12;21)[ETV6–RUNX1]-positive leukaemia using multiple tiling PCR on whole-genome-amplified DNAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Characterizing chromosomal break points of t(12;21)[ETV6–RUNX1]-positive leukaemia using multiple tiling PCR on whole-genome-amplified DNA Leukemia advance online publication, August 27, 2009. doi:10.1038/leu.2009.170 Authors: U Lausten-Thomsen, H O Madsen & K Schmiegelow (Source: Leukemia)
Source: Leukemia - July 26, 2009 Category: Hematology Authors: U Lausten-ThomsenH O MadsenK Schmiegelow Source Type: journals

Analyses of TET2 mutations in post-myeloproliferative neoplasm acute myeloid leukemiasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
O A Bernard & F Nguyen-Khac (Source: Leukemia)
Source: Leukemia - July 26, 2009 Category: Hematology Authors: L CouronnéE LippertJ AndrieuxO KosmiderI Radford-WeissD PentherN DastugueF MugneretM LafageN GachardN NadalO A BernardF Nguyen-Khac Source Type: journals

Harmonization of molecular monitoring of CML therapy in EuropeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
G Saglio & A Hochhaus (Source: Leukemia)
Source: Leukemia - July 26, 2009 Category: Hematology Authors: M C MüllerN C P CrossP ErbenT SchenkB HanfsteinT ErnstR HehlmannS BranfordG SaglioA Hochhaus Source Type: journals

Identification of a novel TEL–Lyn fusion gene in primary myelofibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Identification of a novel TEL–Lyn fusion gene in primary myelofibrosis Leukemia advance online publication, August 27, 2009. doi:10.1038/leu.2009.167 Authors: H Tanaka, M Takeuchi, Y Takeda, S Sakai, D Abe, C Ohwada, E Sakaida, N Shimizu, Y Saito, S Miyagi, A Iwama & C Nakaseko (Source: Leukemia)
Source: Leukemia - July 26, 2009 Category: Hematology Authors: H TanakaM TakeuchiY TakedaS SakaiD AbeC OhwadaE SakaidaN ShimizuY SaitoS MiyagiA IwamaC Nakaseko Source Type: journals

Nilotinib concentration in cell lines and primary CD34+ chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transportersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nilotinib concentration in cell lines and primary CD34+ chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters Leukemia advance online publication, August 27, 2009. doi:10.1038/leu.2009.166 Authors: A Davies, N E Jordanides, A Giannoudis, C M Lucas, S Hatziieremia, R J Harris, H G Jørgensen, T L Holyoake, M Pirmohamed, R E Clark & J C Mountford (Source: Leukemia)
Source: Leukemia - July 26, 2009 Category: Hematology Authors: A DaviesN E JordanidesA GiannoudisC M LucasS HatziieremiaR J HarrisH G JørgensenT L HolyoakeM PirmohamedR E ClarkJ C Mountford Source Type: journals