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JAK2 mutation in a patient with CLL with coexistent myeloproliferative neoplasm (MPN)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: JAK2 mutation has not been described in patients with chronic lymphocytic leukemia (CLL). We found JAK2 mutation in a patient with CLL and coexisting myeloproliferative neoplasm (MPN). In this patient, we demonstrated the presence of the JAK2 mutation in CD34+ progenitor cells, myeloid lineage cells, megakaryocytes, B lymphocytes but not in T lymphocytes. This case represents the first case report of JAK2 mutation in CLL and may also suggest that, JAK2 mutation most likely represents a secondary event from primary gene mutations involving the primitive stem cells which give rise to MPN and CLL. Furthermore, in th...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Srinivas Kodali, Chi Chen, Chenthilmurugan Rathnasabapathy, Jen Chin Wang Tags: e-page Letters (available online only) Source Type: journals

Nilotinib post-liver transplantation for acute hepatic failure related to imatinibEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: This is the case report of a 47-year-old woman referred to our institution due to acute liver failure related to imatinib, who was submitted to a successful liver transplantation. Nilotinib was safely used post-transplant. (Source: Leukemia Research)
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Guilherme F. Perini, Fabio P.S. Santos, Vaneuza Funke, Jefferson Ruiz, Ben-Hur Ferraz Neto, Nelson Hamerschlak Tags: e-page Letters (available online only) Source Type: journals

Vindesine-induced neuropathy mimicking Guillain-Barré syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A 13-year-old girl with acute lymphoblastic leukaemia, who was being treated with chemotherapy (including vindesine), developed paraplegia without paresthesia, which mimic Guillain-Barré syndrome. Spinal fluid analysis showed a normal protein level, vindesine neuropathy seemed to be the cause of the patient's neurological symptoms. The patient seemed to benefit from human normal immunoglobulin therapy and recovered 4 weeks later. (Source: Leukemia Research)
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Lihui Liu, Bing Shi, Liping Ye, Jiangang Jin, Yuzhu Zhang, Wenqing Hu, Mingjuan Liu, Guojian Li Tags: e-page Letters (available online only) Source Type: journals

Acute myeloid leukemia and ischemic heart disease successful first line treatment with clofarabine as single agentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Standard induction chemotherapy for acute myeloid leukemia is characterized by a combination of an anthracycline drug and the antimetabolite cytosine arabinoside. Treatment of acute myeloid leukemia (AML) patients with pre-existing ischemic heart disease is a matter of debate, because anthracycline-induced cardiotoxicity may potentiate myocardial dysfunction. In addition, chemotherapy with its inevitable subsequent pancytopenia clearly increases the risk of hemodynamic complications, mostly due to infections and gastrointestinal mucosal injury. These patients are, therefore, not eligible for intensive chemotherapy. Clofara...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Saveria Capria, Silvia Maria Trisolini, Angela Matturro, Livia Santini, Luisa Cardarelli, Robin Foà, Giovanna Meloni Tags: e-page Letters (available online only) Source Type: journals

TCRG gene rearrangement patterns in brazilian children with ALL: An updateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the editor: As a clonal disease, acute lymphoblastic leukemia (ALL) carries unique markers in the context of rearranged immunoglobulin (Ig) and T-cell receptor genes (TCR) that serve as targets to quantitate the levels of minimal residual disease (MRD), which is currently the most reliable prognostic factor in ALL . (Source: Leukemia Research)
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Mônica Aparecida Ganazza, Juliana Godoy Assumpção, Marcela de Araújo, Carlos Alberto Scrideli, Luiz Gonzaga Tone, Silvia Regina Brandalise, José Andrés Yunes Tags: e-page Letters (available online only) Source Type: journals

Inflammatory myofibroblastic tumor of the bone marrowEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inflammatory myofibroblastic tumor (IMT) is a mass-forming lesion, included in a variety of non-neoplastic and neoplastic entities, billed by the generic term of inflammatory pseudotumor, sharing common histological features, characterized by spindle cell proliferation, with a varying infiltrate of plasma cells, lymphocytes, eosinophils and neutrophils, in a myxoid to fibrous stroma. (Source: Leukemia Research)
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Alessia Saviola, Giulio Rossi, Goretta Bonacorsi, Fabio Forghieri, Claudia Fiorani, Tullio Artusi, Giovanni Emilia, Mario Luppi, Giuseppe Longo, Giuseppe Torelli Tags: e-page Letters (available online only) Source Type: journals

Acute lymphoblastic leukaemia with unusual chromosomal abnormality: t(3;9) (p21;p13), del(10p12) [13]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of pre-B acute lymphoblastic leukaemia with an unusual translocation between chromosome 3 and 9, with del(10p12) [13]. The diagnosis at presentation was made by the morphology, cytochemistry and immunophenotyping. Cytogenetic analysis was also done at presentation. To the best of our knowledge and after literature search this appears to be a rare cytogenetic abnormality in ALL. (Source: Leukemia Research)
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Bhavna Dhingra, Rahul Bhargava, Pravas Mishra Tags: e-page Letters (available online only) Source Type: journals

Emergence of clonal chromosomal abnormalities in Philadelphia negative hematopoiesis in chronic myeloid leukemia patients treated with nilotinib after failure of imatinib therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clonal cytogenetic abnormalities (CAs) in Philadelphia negative (Ph−) metaphases have been widely observed during imatinib treatment in patients with chronic myeloid leukemia (CML) . Recently, the appearance of such abnormalities in some CML patients, treated with dasatinib after imatinib failure, has been described . To the best of our knowledge, only one patient has been reported to develop a cytogenetic abnormality in Ph− clone during nilotinib treatment, following imatinib . The incidence and consequences of CAs in Ph− cells during treatment with second generation tyrosine kinase inhibitors (TKIs) should be exten...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Carmen Baldazzi, Simona Luatti, Giulia Marzocchi, Monica Stacchini, Carla Gamberini, Fausto Castagnetti, Francesca Palandri, Gianantonio Rosti, Michele Baccarani, Nicoletta Testoni Tags: e-page Letters (available online only) Source Type: journals

Third-party mesenchymal stem cells as part of the management of graft-failure after haploidentical stem cell transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mortality of secondary graft rejection after allogeneic hematopoietic stem cell transplantation (HSCT) is high with an overall survival of 37% . Different factors associated with secondary graft rejection have been identified: low dose of transplanted CD34+ cells/kg, reduced intensity of the conditioning regimen, certain HLA-disparities between donor and recipient, T-cell depleted grafts, GvHD and occurrence of viral infections. Management of graft failure is mainly based on re-transplantation . (Source: Leukemia Research)
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Malte von Bonin, Alexander Kiani, Uwe Platzbecker, Johannes Schetelig, Kristina Hölig, Uta Oelschlägel, Christian Thiede, Gerhard Ehninger, Martin Bornhäuser Tags: e-page Letters (available online only) Source Type: journals

Successful imatinib mesylate therapy for acquired von Willebrand syndrome in chronic myelogenous leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe herein the case of a patient with chronic myelogenous leukemia (CML) accompanied by AvWS who was successfully treated with imatinib mesylate. (Source: Leukemia Research)
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Michihiro Uchiyama, Takashi Ikeda Tags: Case of the Month Source Type: journals

Three clinical-stage tumor targeting antibodies reveal differential expression of oncofetal fibronectin and tenascin-C isoforms in human lymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study provides a rationale basis for the clinical investigation of therapeutic derivatives of the three antibodies in lymphoma patients. (Source: Leukemia Research)
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Christoph Schliemann, Andrea Wiedmer, Marta Pedretti, Monika Szczepanowski, Wolfram Klapper, Dario Neri Tags: Brief Communications Source Type: journals

Dexamethasone-induced apoptosis and up-regulation of Bim is dependent on glycogen synthase kinase-3Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we show that apoptosis induced by dexamethasone (Dex), a synthetic glucocorticoid, was dependent on mitochondria, since overexpression of Bcl-XL prevented Dex-induced apoptotic changes. Dominant negative (DN) caspase-9 also prevented Dex-induced apoptotic changes including the loss of mitochondrial membrane potential indicating that caspase-9 controls mitochondrial changes. In addition, we evaluated the role of glycogen synthase kinase (GSK3) in Dex-induced apoptosis. Inhibition of GSK3 attenuated Dex-induced up-regulation of Bim, loss of mitochondrial membrane potential, release of cyt c and DNA fragmentati...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Ulla Nuutinen, Antti Ropponen, Sanna Suoranta, Jonna Eeva, Mine Eray, Riikka Pellinen, Jarmo Wahlfors, Jukka Pelkonen Tags: Brief Communications Source Type: journals

Significance of four MRD markers in MRD-based treatment strategy for childhood acute lymphoblastic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Newly diagnosed children with ALL (n=32) were treated on a protocol incorporating minimal residual disease (MRD)-based treatment decisions. MRD was monitored at 4 time points by semi-quantitative PCR detection of antigen receptor gene rearrangement, flow cytometry, quantitative RT-PCR detection of chimeric gene transcripts and overexpressed WT1 mRNA. Four patients positive for MRD at week 5 were treated with an intensified regimen. Median follow-up was 5.0 years (range 3.8–6.6 years) with a 4-year event-free survival rate of 93.8±4.3%. This MRD-based treatment strategy seems to be highly successful and may imp...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Akihisa Sawada, Naoki Sakata, Tomoko Kishimoto, Banryoku Higuchi, Maho Koyama, Osamu Kondo, Emiko Sato, Takayuki Okamura, Masahiro Yasui, Masami Inoue, Akira Yoshioka, Keisei Kawa Tags: Brief Communications Source Type: journals

High FOXO3a expression is associated with a poorer prognosis in AML with normal cytogeneticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The PI3/AKT pathway is up-regulated in acute myeloid leukemia (AML), but its prognostic relevance in cytogenetically normal AML (CN-AML) is unclear. We evaluated RNA levels of AKT and two downstream substrates (FOXO3a-p27) in 110 de novo CN-AML, included in the Spanish PETHEMA therapeutic protocols. Patients with high FOXO3a gene expression displayed shorter OS (p=0.015) and RFS (p=0.048) than low FOXO3a expressers. Features selected in the multivariate analysis as having an independent prognostic value for a shorter survival were WBC>50×109/L, age >65 years and high FOXO3a expression. We concluded that FOXO3a a...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Carlos M. Santamaría, Maria C. Chillón, Ramón García-Sanz, Cristina Pérez, María D. Caballero, Fernando Ramos, Alfonso García de Coca, José M. Alonso, Pilar Giraldo, Teresa Bernal, José A. Queizán, Juan N. Rodriguez, Pascual Fernández-Abellán, Tags: Brief Communications Source Type: journals

Reduction of BCR-ABL1 mutant clones after discontinuation of TKI therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In this letter we describe two case reports of CML patients with acquired mutations of the BCR-ABL1 kinase domain, in whom the mutant clone regressed and drug sensitivity was restored after temporary interruption of TKI.We believe that temporary interruption of an ATP-competitive tyrosine kinase inhibitor and switching to non-selective therapy can be a valid therapeutic option in CML patients. In addition, we highlight the potential of a flow cytometric CRKL phosphorylation assay to explore TKI sensitivity in CML cells ex vivo, and its correlation with clinical and haematological sensitivity or resistance. (Sourc...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Karolien Beel, Ann Janssens, Gregor Verhoef, Peter Vandenberghe Tags: Brief Communications Source Type: journals

Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NFκB activity in Follicular LymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: FOXP1 is a transcriptional repressor that has been proposed to repress the expression of some NFκB-responsive genes. Furthermore, truncated forms of FOXP1 have been associated with a subtype of Diffuse Large B-cell Lymphoma characterised by constitutive NFκB activity, indicating that they may inhibit this repression. We have shown that FL tumors have increased relative abundance of truncated FOXP1 isoforms and this is associated with increased expression of NFκB-associated genes. Our results provide strong evidence that relative FOXP1 isoform abundance is associated with NFκB activity in FL, and could potenti...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Michael R. Green, Maher K. Gandhi, Mark J. Courtney, Paula Marlton, Lyn Griffiths Tags: Brief Communications Source Type: journals

Differential regulation of 11β-hydroxysteroid dehydrogenase-1 by dexamethasone in glucocorticoid-sensitive and -resistant childhood lymphoblastic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Glucocorticoid therapy forms a crucial first-line treatment for childhood acute lymphoblastic leukemia (ALL). However, glucocorticoid resistance is a therapeutic problem with an unclear molecular mechanism. 11β-Hydroxysteroid dehydrogenase-1 (11β-HSD1) is expressed in glucocorticoid target tissue, where it regenerates active glucocorticoids from inert 11keto-glucocorticoids, amplifying intracellular glucocorticoid levels. Here, we show 11β-HSD1 expression in leukemic cells from ALL patients (n=14). 11β-HSD1 was differentially regulated by glucocorticoids between glucocorticoid-sensitive and -resistant ALL cel...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Shuji Sai, Yuichi Nakagawa, Kimiyoshi Sakaguchi, Shuichi Okada, Hiroyoshi Takahashi, Teruaki Hongo, Jonathan R. Seckl, Karen E. Chapman, Takehiko Ohzeki Tags: Brief Communications Source Type: journals

Prednisolone exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells: Relation to early gene expressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Resistance or sensitivity to glucocorticoids is considered to be of crucial importance for disease prognosis in childhood acute lymphoblastic leukemia. Prednisolone exerted a delayed biphasic effect on the resistant CCRF-CEM leukemic cell line, necrotic at low doses and apoptotic at higher doses. At low doses, prednisolone exerted a pre-dominant mitogenic effect despite its induction on total cell death, while at higher doses, prednisolone's mitogenic and cell death effects were counterbalanced. Early gene microarray analysis revealed notable differences in 40 genes. The mitogenic/biphasic effects of prednisolone...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: George I. Lambrou, Spiros Vlahopoulos, Chrisanthi Papathanasiou, Maria Papanikolaou, Michael Karpusas, Emmanouil Zoumakis, Fotini Tzortzatou-Stathopoulou Tags: Laboratory Studies Source Type: journals

Clofarabine induces hypomethylation of DNA and expression of Cancer-Testis antigensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, treatment of lymphoid tumor cells with low dose clofarabine upregulated the expression of Sp17 and SPAN-Xb. This was associated with an increase in hypomethylated CpG dinucleotides and a decrease in global DNA methylation, as demonstrated by decreases in the percent of methylated Alu repeats. The most optimal concentration of clofarabine to induce DNA hypomethylation and CT antigen expression was between 1×10−9 and 1×10−8M. Above this, clofarabine resulted in tumor cell growth inhibition and apoptosis. Our results provide the first evidence for the CT antigen-inducing and DNA hypomethylating property o...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Yana Zhang, Masum Shahriar, Jian Zhang, Sharif Uddin Ahmed, Seah H. Lim Tags: Laboratory Studies Source Type: journals

OH-2, a hyperdiploid myeloma cell line without an IGH translocation, has a complex translocation juxtaposing MYC near MAFB and the IGK locusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Multiple myeloma can be classified into hyperdiploid (HRD) (with 48–74 chromosomes) and non-hyperdiploid tumors (usually with immunoglobulin heavy chain translocations). The OH-2 human myeloma cell line (HMCL) retains the same HRD genotype as the primary tumor, with extra copies of chromosomes 3, 7, 15, 19, and 21. Both OH-2 and primary cells have a complex secondary translocation in which the IGK 3′ enhancer is inserted between MYC and MAFB, resulting in dysregulation of both oncogenes. OH-2 provides a unique example of an HMCL and the corresponding primary tumor that are shown to share the same HRD genotype...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Thea Kristin Våtsveen, Erming Tian, Stine H. Kresse, Leonardo A. Meza-Zepeda, Ana Gabrea, Oleg Glebov, Hong Yan Dai, Anders Sundan, W. Michael Kuehl, Magne Børset Tags: Laboratory Studies Source Type: journals

2-(1-Hydroxethyl)-4,8-dihydrobenzo[1,2-b:5,4-b′]dithiophene-4,8-dione (BTP-11) enhances the ATRA-induced differentiation in human leukemia HL-60 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: 2-(1-Hydroxethyl)-4,8-dihydrobenzo[1,2-b:5,4-b′]dithiophene-4,8-dione (BTP-11) is a potent enhancer for all-trans retinoic acid (ATRA)-induced differentiation in HL-60 cells. Combination of BTP-11 and ATRA cut down the concentration of ATRA significantly, and that BTP-11 promoted the progression of ATRA-induced into the terminal granulocytic differentiation. Further, Western blot analysis revealed that combination of BTP-11 and ATRA decreased cyclin D/CDK4 and increased C/EBPɛ protein expression to arrest the cells into G0/G1 phase leading to granulocytic maturation. These results confirmed that BTP-11 is a po...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Chun-Jen Chen, Yen-Fang Wen, Pi-Tsan Huang, Mei-Hua Hsu, Kuo-Hsiung Lee, Mei-Hwai Chen, Wuu-Chian Shin, Li-Jiau Huang, Sheng-Chu Kuo Tags: Laboratory Studies Source Type: journals

Identification of annexin 1 as a PU.1 target gene in leukemia cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: To identify PU.1 downstream target genes, we first established PU.1-knockdown K562 (K562PU.1KD) cells expressing reduced levels of PU.1 by stably transfected PU.1 siRNAs. From microarray analysis, we found that several genes including annexin 1 were markedly induced in K562PU.1KD cells. Annexin 1 is a calcium- and phospholipid-binding protein and increased expression leads to the constitutive activation of extracellular signal-regulated kinase (ERK). Consistent with this, we observed constitutive activation of ERK in K562PU.1KD cells. Furthermore, we revealed the mRNA expression of annexin 1 was negatively correl...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Yuko Iseki, Akemi Imoto, Toshio Okazaki, Hideo Harigae, Shinichiro Takahashi Tags: Laboratory Studies Source Type: journals

Growth inhibition of AML cells with specific chromosome abnormalities by monoclonal antibodies to receptors for vascular endothelial growth factorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: By using neutralizing monoclonal antibodies to vascular endothelial growth factor receptor type 1 (VEGFR1) and VEGFR2, we have shown that acute myelogenous leukemia (AML) cells with specific chromosome abnormalities are dependent on VEGF/VEGFR system. AML with t(8;21) is the most dependent subtype on VEGF with both VEGFR1 and VEGFR2. t(15;17)AML cells depend on VEGF with VEGFR1. AML cells with 11q23 abnormalities showed variable dependence on VEGF. The growth of t(11;19)AML cells are most extensively inhibited by anti-VEGFR1 antibody. Then, the growth of Kasumi-1, a t(8;21) cell line was suppressed by either anti...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Norikazu Imai, Hiroshi Miwa, Masato Shikami, Kazuto Suganuma, Mayuko Gotoh, Akihito Hiramatsu, Motohiro Wakabayashi, Masaya Watarai, Ichiro Hanamura, Akira Imamura, Hidetsugu Mihara, Kenya Shitara, Masabumi Shibuya, Masakazu Nitta Tags: Laboratory Studies Source Type: journals

WT1 monitoring in core binding factor AML: Comparison with specific chimeric productsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Minimal residual disease may help to establish clinical decisions in patients with AML. WT1 offers the possibility to analyze those cases without currently known underlying genetic abnormalities. To compare the value of chimeric specific quantitative PCR with WT1 PCR in CBF acute leukemia, 445 samples from 96 AML (49 AML1-ETO+ and 47 CBFB-MYH11+) cases were included in the study. For each sample AML1-ETO or CBFB-MYH11 levels obtained using the conditions of the BIOMED group were compared with the results of WT1 levels using sensitive primers and conditions. Simultaneously, normal range expression of WT1 was estab...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Adriana Lasa, Maite Carricondo, Camino Estivill, Elena Bussaglia, Ignasi Gich, Salut Brunet, Anna Aventin, Jorge Sierra, Josep F. Nomdedéu Tags: Clinical Studies Source Type: journals

Reduction in multi-lineage and erythroid progenitors distinguishes myelodysplastic syndromes from non-malignant cytopeniasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We studied the diagnostic role of CFC assays in myelodysplastic syndromes (MDS) using CFC data from bone marrow (BM) and peripheral blood (PB) of 221 MDS patients, 51 patients with non-malignant causes of cytopenia and/or dysplasia and 50 normal controls. A consistent decrease in BM but not PB multi-lineage and erythroid progenitor frequencies was seen in patients with MDS compared to controls (P (Source: Leukemia Research)
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Suzanne M. Vercauteren, Ali Bashashati, Donghong Wu, Ryan R. Brinkman, Connie Eaves, Allen Eaves, Aly Karsan Tags: Clinical Studies Source Type: journals

Pronostic significance of angiogenic/lymphangiogenic, anti-apoptotic, inflammatory and viral factors in 88 cases with diffuse large B cell lymphoma and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background: Diffuse large B cell lymphoma (DLBCL) is the most common subtype of Non-Hodgkins lymphomas (NHL). The outcome of these patients shows a wide variation. We evaluated the effect of six biologic parameters including Cyclooxygenase-2 (Cox-2), Survivin, Epstein Barr Virus (EBV), Vascular Endothelial Growth Factor-A (VEGF-A), Vascular Endothelial Growth Factor-C (VEGF-C), Thrombospondin-1 (TSP-1) and clinical parameters.Patients and methods: A follow up study was conducted and 88 cases with DLBCL were included in the study. The data of 72 patients were eligible for the survival analyses. Immunohistochemistr...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Semra Paydas, Melek Ergin, Gulsah Seydaoglu, Seyda Erdogan, Sinan Yavuz Tags: Clinical Studies Source Type: journals

Strong correlation between VEGF and MCL-1 mRNA expression levels in B-cell chronic lymphocytic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Expression of the anti-apoptotic myeloid cell leukemia-1 (MCL-1) gene is a novel prognostic factor in B-cell chronic lymphocytic leukemia (B-CLL). Vascular and endothelial growth factor (VEGF) and interleukin-6 (IL-6) are able to upregulate MCL-1 via autocrine signaling loops. In 88 B-CLL patients, we found a strong correlation of MCL-1 gene expression with VEGF (P (Source: Leukemia Research)
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Lauren Véronèse, Olivier Tournilhac, Pierre Verrelle, Frédéric Davi, Guillaume Dighiero, Emmanuel Chautard, Richard Veyrat-Masson, Fabrice Kwiatkowski, Carole Goumy, Laetitia Gouas, Jacques-Olivier Bay, Philippe Vago, Andrei Tchirkov Tags: Clinical Studies Source Type: journals

Clinical features and outcome of Chinese patients with monoclonal B-cell lymphocytosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: B-cell chronic lymphocytic leukemia (CLL) is the most common type of adult leukemias in the Western countries, however, infrequent in the Eastern. A diagnosis of CLL requires a count of B-lymphocytes ≥5.0×109/L. Asymptomatic person with (Source: Leukemia Research)
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Wei Xu, Jian-Yong Li, Yu-Jie Wu, Xin Cao, Lei Fan, Chun Qiao, Qiong Liu, Lin Yao, Kou-Rong Miao Tags: Clinical Studies Source Type: journals

Bortezomib in combination with dexamethasone and subsequent thalidomide for newly-diagnosed multiple myeloma: A Chinese experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our preliminary experience in Chinese patients indicated that bortezomib–dexamethasone–thalidomide is highly effective in newly-diagnosed MM. Grade three and 4 toxicities are rare after median 2 cycles of therapy. The relative lower rates of neuropathy and DVT/PE in the Chinese patients with MM are being cautiously observed. (Source: Leukemia Research)
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Weiyan Zheng, Guoqing Wei, Xiujin Ye, Jingsong He, Li Li, Wenjun Wu, Jimin Shi, Jie Zhang, Weijia Huang, Wanzhuo Xie, Yi Luo, Xingkui Xue, Maofang Lin, He Huang, Zhen Cai Tags: Clinical Studies Source Type: journals

Genetic variation in cell cycle and apoptosis related genes and multiple myeloma riskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Genetic variation may be an important risk factor for multiple myeloma. A hallmark of tumor formation and growth is cell cycle dysregulation and apoptosis avoidance. We previously reported the association of genetic variation in caspase genes, the apoptotic-regulating family, and multiple myeloma risk. To further examine if genetic variation in key cell cycle and apoptosis genes alters multiple myeloma risk, we genotyped 276 tag SNPs in 27 gene regions in a population-based case–control study of non-Hispanic Caucasian women (108 cases; 482 controls) in Connecticut. Logistic regression assessed the effect of eac...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: H. Dean Hosgood, Dalsu Baris, Yawei Zhang, Sonja I. Berndt, Idan Menashe, Lindsay M. Morton, Kyoung-Mu Lee, Meredith Yeager, Shelia H. Zahm, Stephen Chanock, Tongzhang Zheng, Qing Lan Tags: Clinical Studies Source Type: journals

Long-term survival in chronic myelocytic leukemia after a first primary malignancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Within the past 10–15 years, major advances in therapy have strongly improved prognosis of patients with chronic myelocytic leukaemia (CML). We estimated trends in 5- and 10-year relative survival of patients developing CML after a previous malignancy in the United States from 1990–1994 to 2000–2004. Period analysis was employed to disclose recent developments with minimum delay. Overall, 5- and 10-year relative survival increased from 17.6% to 37.7% (p (Source: Leukemia Research)
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Hermann Brenner, Adam Gondos, Dianne Pulte Tags: Clinical Studies Source Type: journals

Characterization of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in Shanghai, China: Molecular and cytogenetic characteristics, IgV gene restriction and hypermutation patternsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The clinical, cytogenetic and molecular features of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), a disease previously considered to be rare in Asia, were examined in consecutive series of 70 cases diagnosed by our laboratory over a 30-month period. Clonal abnormalities were observed in 80% of CLL/SLL cases using a combination of conventional cytogenetic and fluorescence in situ hybridization (FISH) analysis. Those involving 14q32/IGH were the most frequent (24 cases), followed by trisomy 12 and 11q abnormalities. IgVH gene usage was non-random with over-representation of VH4-34, VH3-23 and a...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Richard D. Irons, Anh Le, Liming Bao, Xiongzeng Zhu, John Ryder, Xiao Qin Wang, Meirong Ji, Yan Chen, Xichun Wu, Guowei Lin Tags: Clinical Studies Source Type: journals

Comorbidities and survival in a large cohort of patients with newly diagnosed myelodysplastic syndromesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study included 1708 MDS patients (age≥66 years) diagnosed in the US during 2001–2002, with follow-up through the end of 2004. Hazard ratios (HRs) were estimated using multivariate Cox proportional hazard models. The median survival time was approximately 18 months. Fifty one percent of MDS patients had comorbid conditions. Patients with comorbid conditions had significantly greater risk of death than those without comorbidities. The HR was 1.19 (95% confidence interval (CI): 1.05–1.36) and 1.77 (95% CI: 1.50–2.08) for those with a Charlson index of 1–2 and ≥ 3, respectively. The risk of death increases wit...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Rong Wang, Cary P. Gross, Stephanie Halene, Xiaomei Ma Tags: Clinical Studies Source Type: journals

MicroRNAs in normal and malignant myelopoiesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: MicroRNAs (miRNAs) are a class of non-coding protein, single-stranded RNA of 18–22 nucleotides, that exert their actions at post-transcriptional level, mostly through base pairing with the 3′-untranslated region of the target mRNA, thus leading to its translational repression and/or degradation. Recent studies have shown that miRNAs play a crucial role in normal hematopoiesis through the control of the expression of key regulators of hematopoiesis (i.e., transcription factors, growth factor receptors, chemokine receptors), involving regulatory loops that selectively operate in the various hematopoietic lineag...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Elvira Pelosi, Catherine Labbaye, Ugo Testa Tags: Timely Topical Review Source Type: journals

How do JAK2-inhibitors work in myelofibrosis: An alternative hypothesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The clinical efficacy of JAK2-inhibitors in patients with myelofibrosis, that involves a rapid and massive reduction of spleen enlargement and improvement of clinical symptoms, is not accompanied by significant modifications of hematologic parameters nor of the burden of JAK2V617F allele. Furthermore, clinical improvement has been reported to occur irrespective of patient's JAK2-mutated status. On the other hand, dramatic changes in plasma cytokine levels have been observed. Based on available information about the role of cytokines in the pathogenesis of myelofibrosis, the hypothesis that the clinical efficacy o...
Source: Leukemia Research - September 18, 2009 Category: Hematology Authors: Alessandro M. Vannucchi Tags: Open Forum Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Leukemia Research)
Source: Leukemia Research - September 18, 2009 Category: Hematology Source Type: journals

JAK2-V617F mutation and Philadelphia positive chronic myeloid leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Less than ten cases of chronic myeloid leukemia (CML) with concomitant presence of BCR-ABL transcript and JAK2-V617F mutation are described in literature . Usually CML developed from a pre-existing JAK2-V617F myeloproliferative disease , or JAK2 mutation arose in CML patients after treatment with imatinib . In all these cases JAK2-V617F mutation seems to precede the acquisition of BCR-ABL translocation . (Source: Leukemia Research)
Source: Leukemia Research - August 20, 2009 Category: Hematology Authors: Leonardo Campiotti, Lorena Appio, Francesco Solbiati, Walter Ageno, Achille Venco Tags: e-page Letters (available online only) Source Type: journals

The role of estrogenic compounds in the etiology of pediatric leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We read with great interest the research article of Schnyder et al. (doi:10.1016/j.leukres.2009.01.023) on the potential role of estrogens in inducing MLL translocations. In order to detect E2- or 4-OH-E2 chromosomal translocations in TK6 human lymphoblastoid cell line, Schnyder et al. developed an inverse PCR assay that amplified Sau3A1 digested/ligated MLL fragments. A similar methodology was previously used both by Libura et al. and our lab to screen for MLL translocations induced by etoposide and dietary topoisomersae II inhibitors. The latter method employs XbaI, an infrequently cutting restriction enzyme, with only ...
Source: Leukemia Research - August 20, 2009 Category: Hematology Authors: Kimberly Vanhees, Laura de Bock, Frederik-Jan van Schooten, Sahar Barjesteh van Waalwijk van Doorn-Khosrovani Tags: e-page Letters (available online only) Source Type: journals

Detection of FLT3/ITD, JAK2(V617F) and NPM1 gene mutations in chronic myelomonocytic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CMML is a clonal disorder of a bone marrow stem cell, characterizes by increased neoplastic myelomonocytes in the bone marrow and peripheral blood . Due to its frequently sharing both myelodysplastic and myeloproliferative characteristics, it has once been separated into MDS subtype (CMML-MDS, WBC count 13×109/L) by the French-American-British Cooperative Leukaemia Group (FAB) . Most recently, World Health Organization (WHO) classification committee classified CMML under the category of MDS/MPD disorders . (Source: Leukemia Research)
Source: Leukemia Research - August 20, 2009 Category: Hematology Authors: Wei Chen, Qin Huang Tags: e-page Letters (available online only) Source Type: journals

Genetic background modulates susceptibility to oncogen-driven proliferation and lymphoma occurrence in mice carrying a deregulated c-myc transgeneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is well known that genetic variations significantly influence susceptibility to cancer in human. It is, thus, difficult to evaluate the relative contributions of modified genes because of the independent segregation of multiple alleles at multiple loci. In order to bypass this problem researchers have focused their attentions on inbred mice that have permitted investigation of disease phenotype in the presence of a homogenous background . Genetic homogeneity is a clear advantage especially for studies investigating oncogene overexpression or loss of tumor suppressor gene expression in a uniform population and needing a ...
Source: Leukemia Research - August 20, 2009 Category: Hematology Authors: Christelle Vincent-Fabert, Rémi Fiancette, Véronique Truffinet, Nadine Cogné, Michel Cogné, Yves Denizot Tags: e-page Letters (available online only) Source Type: journals

A delayed yet durable response to very short lenalidomide therapy and unexpected clone redistribution in a case of myelodysplastic syndrome with del(5q) and del(20q)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The immunomodulatory drug lenalidomide alleviates transfusion dependence and improves erythropoiesis in MDS patients with del(5q) . In vitro studies showed that lenalidomide has a selective inhibitory effect on the del(5q) clone and is therefore believed to achieve its therapeutic effect by eliminating the del(5q) . However, the presence and number of karyotype abnormalities besides del(5q) appeared unrelated to the therapeutic response . Certain MDS patients without chromosomal abnormalities have also responded to lenalidomide , which suggests multiple mechanisms of action and warrant further investigation. In addition, i...
Source: Leukemia Research - August 20, 2009 Category: Hematology Authors: Feng Xu, Xiao Li, ChunKang Chang, Qi He, Zheng Zhang, QianQiao Zhang, LingYun Wu Tags: e-page Letters (available online only) Source Type: journals

Chronic myelogenous leukemia showing biphenotypic blast crisis followed by lineage switch to B lymphoblastic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Lineage switch is a very rare event in blastic crisis of chronic myelogenous leukemia (CML-BC). To our knowledge, only three cases of lineage switch between lymphoid and myeloid/myelomonocytic lineages have been reported in the literature. Here, we report a novel case of imatinib-resistant CML-BC, in which the blast lineage switched from biphenotypic to B-lymphoid. (Source: Leukemia Research)
Source: Leukemia Research - August 20, 2009 Category: Hematology Authors: Seung Hwan Oh, Tae Sung Park, Hye Ran Kim, Ja Young Lee, Jae Hyun Kim, Jeong Hwan Shin, Jeong Nyeo Lee Tags: e-page Letters (available online only) Source Type: journals

l-Asparaginase induced severe hypertriglyceridemia in acute lymphoblastic leukemia with 11q23 abnormalityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 17-year-old girl (weight 70th centile and stature 50th centile for age, NCHS) was diagnosed with precursor B acute lymphoblastic leukemia with 11q23 abnormality. She achieved complete remission with a 4 drug induction regimen (MCP 841 protocol) . She went on to receive, consolidation, high dose methotrexate and reinduction. Ten doses of l-asparaginase (6000IU/m2) were administered during reinduction. On day 33 of reinduction her blood sample was reported to be highly lipemic. The serum triglyceride (TG) and cholesterol levels were 5250mg/dl and 672mg/dl respectively. She was asymptomatic and was started on Atorvastatin a...
Source: Leukemia Research - August 20, 2009 Category: Hematology Authors: Sandeep Jain, Rahul Naithani, Gauri Kapoor, Triloki Nath Tags: e-page Letters (available online only) Source Type: journals

Lenalidomide can induce graft versus leukemia effect in primary plasma cell leukemia: A case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Primary plasma cell leukemia (PPCL) is an aggressive and rare variant (approximately 2–4% of all new myeloma diagnoses) of multiple myeloma (MM) . The prognosis is usually poor: overall response rate to standard chemotherapy was reported to be 45% in 7 recent series including 136 patients and the median overall survival (OS) was only 7 months. Allogeneic hematopoietic stem cell transplantation (HSCT) results in the sustained long-term survival of eligible patients , suggesting the possibility of a graft-versus-leukemia (GVL) effect in this setting. However, relapse and progression after allogeneic HSCT are rather common ...
Source: Leukemia Research - August 20, 2009 Category: Hematology Authors: Attilio Olivieri, Immacolata Attolico, Michele Cimminiello, Giancarlo Discepoli, Rosa Anna Cifarelli Tags: e-page Letters (available online only) Source Type: journals

Acute promyelocytic leukemia in patients with severe psoriasis vulgarisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has made acute promyelocytic leukemia (APL) a curable leukemia. The actions of ATRA and ATO on the PML-RARα fusion aberration in APL are well studied. The availability of oral ATO allows outpatient maintenance treatment of these cases and few patients would require haematopoietic stem cell transplantation (HSCT), even for disease relapse. (Source: Leukemia Research)
Source: Leukemia Research - August 20, 2009 Category: Hematology Authors: Wing-yan Au, Chi-keung Yeung Tags: e-page Letters (available online only) Source Type: journals

Primary myelofibrosis with concurrent precursor T-cell lymphoblastic lymphoma of the spleen in a 26-year-old patientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by abnormal bone marrow megakaryocyte proliferation with reticulin and collagen fibrosis, leukoerythroblastosis, anemia, increased level of serum lactate dehydrogenase and splenomegaly . It is a rare condition with a median age of ∼65 years at diagnosis and an average life expectancy of ∼5–7 years, approaching 15 years in younger patients with good prognostic factors. Transformation to acute myeloid leukemia is a cause of death in 8–23% of patients within 10 years after establishing the initial diagnosis of PMF . However, there are reports o...
Source: Leukemia Research - August 20, 2009 Category: Hematology Authors: Matjaz Sever, Jeffrey L. Jorgensen, Inga Gurevich, Mariana Pinheiro, Srdan Verstovsek Tags: e-page Letters (available online only) Source Type: journals

Bilateral primary small lymphocytic lymphoma of the lacrimal sac and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tumors of the nasolacrimal system are rare and 90% of these tumors are of epithelial origin . Lymphomas involving the lacrimal sac (LS) are usually secondary to systemic lymphoreticular involvement . Because primary lymphoma of the LS is rare, clinicopathological features and optimal therapy are not well established . In this case, we report on a patient presented with primary small lymphocytic lymphoma (SLL) of the bilateral lacrimal gland. (Source: Leukemia Research)
Source: Leukemia Research - August 20, 2009 Category: Hematology Authors: Bala Basak Oven Ustaalioglu, Ahmet Bilici, Mesut Seker, Mahmut Gumus, Nagihan Özdemir, Tarik Salman, Mustafa Yaylaci Tags: e-page Letters (available online only) Source Type: journals

Primary cutaneous diffuse large B-cell lymphoma, leg type, with expression of both vascular endothelial growth factor and its receptorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of PCLBCL, leg type, accompanied by elevation of serum vascular endothelial growth factor (VEGF) and co-expression of VEGF and its receptors in both lymphoma cells and endothelial cells of the tumor vasculature, suggesting that these findings might contribute to the poor prognosis of PCLBCL, leg type. (Source: Leukemia Research)
Source: Leukemia Research - August 20, 2009 Category: Hematology Authors: Shoko Nakayama, Taiji Yokote, Kichinosuke Kobayashi, Yuji Hirata, Toshikazu Akioka, Takuji Miyoshi, Satoko Oka, Kazuki Iwaki, Nobuya Hiraoka, Ayami Takayama, Takayuki Takubo, Motomu Tsuji, Toshiaki Hanafusa Tags: e-page Letters (available online only) Source Type: journals

Isolated CNS lymphoid blast crisis in a patient with imatinib-resistant chronic myelogenous leukemia: Case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chronic myelogenous leukemia (CML) is classified as one of the myeloproliferative disorders, and is known to have a triphasic clinical course. Blast crisis is a critical phase resembling acute leukemia. First and second generation oral tyrosine kinase inhibitors target the pathogenesis of CML. Extra-medullar manifestation is a known complication of acute lymphoblastic leukemia (ALL) and lymphoid blast crisis of CML. The central nervous system is a sanctuary site of relapse after chemotherapy or hematopoietic stem cell transplantation. We now report an isolated CNS lymphoid blast crisis in a patient with CML on dasatinib. (...
Source: Leukemia Research - August 20, 2009 Category: Hematology Authors: Philippe Aftimos, Fady Nasr Tags: e-page Letters (available online only) Source Type: journals

A case of Philadelphia Positive Acute Lymphoblastic Leukaemia with three different phenotypic lineage, each one presenting the same BCR-ABL hybrid transcriptEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukaemia (ALL) is characterized by the balanced translocation t(9;22)(q34;q11.2), which causes the joining of 3′ sequences of Abelson proto-oncogene on chromosome 9 to the 5′ sequences of the BCR gene on chromosome 22 resulting into the BCR-ABL hybrid transcript. (Source: Leukemia Research)
Source: Leukemia Research - August 20, 2009 Category: Hematology Authors: Matteo Parma, Federica Colnaghi, Arianna Colombo, Elena Elli, Fabio Rossi, Giuseppe Gaipa, Vincenzo Rossi, Ivana Casaroli, Andrea Biondi, Enrico Maria Pogliani Tags: e-page Letters (available online only) Source Type: journals