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The solubilisation of boar sperm membranes by different detergents - a microscopic, MALDI TOF MS, 31P NMR and PAGE study on membrane lysis, extraction efficiency, lipid and protein compositionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The boar sperm membranes are solubilised to a different extent by the used detergents. Particularly, the very unique DRMs isolated after Triton X-100 exposure are interesting candidates for further studies regarding the architecture of sperm. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - November 11, 2009 Category: Lipidology Authors: Ulrike JakopBeate FuchsRosmarie SuSZGudrun WibbeltBeate BraunKarin MullerJurgen Schiller Source Type: journals

Association of serum levels of lipid and its novel constituents with the different stages of esophageal carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present study shows that the decreased oxLDL and oxLDL-ab and the elevated oxLDL-lgM serum levels may relate to the development and progression of ESSC. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - October 29, 2009 Category: Lipidology Authors: Yutao DiaoHao LiHuiqing LiYingzhi ZhouQing MaYan WangDong Li Source Type: journals

Correction: Modulation Peroxisome Proliferators Activated Receptor alpha (PPAR alpha) and Acyl Coenzyme A: Cholesterol Acyltransferase1 (ACAT1) Gene expression by Fatty Acids in Foam cellEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Following publication of this work [1] Dr Emamian has requested to be be removed as an author as although he saw the first draft he did not see the second and did not approve the work for publication. He also specifically requested not to be included as an author. An apology is extended to Dr Emamian. The Authors Contributions section has been modified as below. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - October 26, 2009 Category: Lipidology Authors: Mahmood DoostiJavad Zavvar RezaMasoud SalehipourMalehieh PacknejadMajed MojarradMansour Heidari Source Type: journals

Amyloid-beta colocalizes with apolipoprotein B in absorptive cells of the small intestineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The findings of this study are consistent with the possibility that amyloid-beta is secreted by enterocytes as an apolipoprotein component of chylomicrons. However, secretion of amyloid-beta appears to be independent of chylomicron biogenesis (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - October 21, 2009 Category: Lipidology Authors: Susan GallowayRyusuke TakechiMenuka Pallebage-GamarallageSatvinder DhaliwalJohn Mamo Source Type: journals

Low and moderate-fat plant sterol fortified soy milk in modulation of plasma lipids and cholesterol kinetics in subjects with normal to high cholesterol concentrations: report on two randomized crossover studiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Although consumption of various plant sterol (PS)-enriched beverages is effective in lowering plasma cholesterol, the lipid-lowering potential of PS in a soymilk format has not been investigated thoroughly. Therefore, to evaluate the efficacy of PS-enriched soy beverages on plasma lipids and cholesterol kinetics, we conducted two separate 28 d dietary controlled cross-over studies. In study 1, the cholesterol-lowering efficacy of a low-fat (2 g/serving) PS enriched soy beverage was examined in 33 normal cholesterolemic subjects in comparison with 1% dairy milk. In study 2, we investigated the efficacy of a mode...
Source: Lipids in Health and Disease - October 19, 2009 Category: Lipidology Authors: Todd RideoutYen-Ming ChanScott HardingPeter Jones Source Type: journals

Long term effects on human plasma lipoproteins of a formulation enriched in butter milk polar lipid.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The study did not show any significant decrease on plasma lipids or lipoprotein levels of an SL-enriched formulation containing 2-3 times more SL than the normal dietary intake on cholesterol, other plasma lipids or on energy intake. The formulation A may, however, have counteracted the trend towards increased blood lipid concentrations caused by increased energy intake that was seen with the B formulation. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - October 15, 2009 Category: Lipidology Authors: Lena OhlssonHans BurlingAke Nilsson Source Type: journals

Gln27Glu variant of Beta2-adrenoceptor gene affects male type fat accumulation in womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The Glu allele of the BAR2 gene may be a risk factor for visceral fat accumulation in young to middle-aged women. However, this polymorphism was not associated with preclinical atherosclerosis. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - October 14, 2009 Category: Lipidology Authors: Tarja KunnasRiikka LahtioMarja-Leena KortelainenAnne KalelaSeppo Nikkari Source Type: journals

A high oleic sunflower oil fatty acid esters of plant sterols mixed with dietary diacylglycerol reduces plasma insulin and body fat accumulation in Psammomys obesusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we used an animal model of type 2 diabetes to assess the effects of a preparation of PS esterified to high oleic sunflower oil fatty acids mixed with dietary diacylglycerol (PS-HOSO) on diabetic related metabolic parameters. Psammomys obesus (P. obesus) were fed high energy (HE) diet supplemented by either PS-HOSO or control oil. Following 4.5 weeks of intervention, animals were divided into fasting and non-fasting modes prior to outcome measurements. Glucose and insulin levels as well as blood lipid profile, body weight, and fat accumulation were evaluated in fasting and non-fasting modes. Results: P. obesus...
Source: Lipids in Health and Disease - October 11, 2009 Category: Lipidology Authors: Ehud ZivNatan PatlasRony KalmanDori PelledYael HerzogTali DrorTzafra Cohen Source Type: journals

Effects of ezetimibe add-on therapy for high-risk patients with dyslipidemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Ezetimibe (Zetia) is a potent inhibitor of cholesterol absorption that has been approved for the treatment of hypercholesterolemia. Statin, an inhibitor of cholesterol synthesis, is the first-choice drug to reduce low-density lipoprotein-cholesterol (LDL-C) for patients with hypercholesterolemia, due to its strong effect to lower the circulating LDL-C levels. Because a high dose of statins cause concern about rhabdomyolysis, it is sometimes difficult to achieve the guideline-recommended levels of LDL-C in high-risk patients with hypercholesterolemia treated with statin monotherapy. Ezetimibe has been reported t...
Source: Lipids in Health and Disease - October 11, 2009 Category: Lipidology Authors: Minako Yamaoka-TojoTaiki TojoRie KosugiYuko HatakeyamaYuki YoshidaYoji MachidaNaoyoshi AoyamaTakashi MasudaTohru Izumi Source Type: journals

Effects of isoflavone-supplemented soy yogurt on lipid parameters and atherosclerosis development in hypercholesterolemic rabbits: a randomized double-blind studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: There is increasing interest in natural treatments to control dyslipidemia and reduce the risk of cardiovascular disease. Previous studies have demonstrated the beneficial effects of soy yogurt fermented with Enterococcus faecium CRL 183 and of dietary isoflavones on the lipid profile. The purpose of the present study was to investigate the effects of isoflavone-supplemented soy yogurt, fermented with E. faecium CRL183, on lipid parameters and atherosclerosis development in rabbits with induced hypercholesterolemia. Methods: Forty-eight rabbits were randomly assigned to eight groups fed on the following diets f...
Source: Lipids in Health and Disease - October 7, 2009 Category: Lipidology Authors: Daniela CavalliniDulcineia AbdallaRegina VendraminiRaquel BedaniLaura BomdespachoNadiege Pauly-SilveiraGraciela de ValdezElizeu Rossi Source Type: journals

Modulation Peroxisome Proliferators Activated Receptor alpha (PPAR alpha) and Acyl Coenzyme A: Cholesterol Acyltransferase1 (ACAT1) Gene expression by Fatty Acids in Foam cellEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In conclusion, it seems that different fatty acids have different effects on gene expression and lipid metabolism and for complete conception study of the genes involved in lipid metabolism in foam cell all at once maybe is benefit. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - September 1, 2009 Category: Lipidology Authors: Javad ZavvarrezaMahmoud DoostiMasoud SalehipourMalehieh PacknegadMajed MojarradMansour HrdaryEffat Emamian Source Type: journals

Modulation Peroxisome Proliferators Activated Receptor alpha (PPAR a) and Acyl Coenzyme A: Cholesterol Acyltransferase1 (ACAT1)gene expression by Fatty Acids in Foam cellEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In conclusion, it seems that different fatty acids have different effects ongene expression and lipid metabolism and for complete conception study of the genesinvolved in lipid metabolism in foam cell all at once maybe is benefit. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - September 1, 2009 Category: Lipidology Authors: Javad ZavvarrezaMahmoud DoostiMasoud SalehipourMalehieh PacknegadMajed MojarradMansour HrdaryEffat Emamian Source Type: journals

Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fatty acid composition of serum lipids and adipose tissue triacylglycerols (AT-TAG) partly reflect dietary fatty acid intake. The fatty acid composition is, besides the diet, also influenced by desaturating enzymes that can be estimated using product-to-precursor fatty acid ratios. The interrelationships between desaturase indices derived from different serum lipid fractions and adipose tissue are unclear, as well as their associations with obesity and insulin resistance. We aimed to investigate cross-sectional correlations between desaturase indices as measured in serum lipid fractions (phospholipids; PL and free fatty ac...
Source: Lipids in Health and Disease - August 26, 2009 Category: Lipidology Authors: Eva WarensjoMagdalena RosellMai-Lis HelleniusBengt VessbyUlf DeFaireUlf Riserus Source Type: journals

Effect of eicosapentaenoic and docosahexaenoic acid on resting and exercise-induced inflammatory and oxidative stress biomarkers: a randomized, placebo controlled, cross-over studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: The purpose of the present investigation was to determine the effects of EPA/DHA supplementation on resting and exercise-induced inflammation and oxidative stress in exercise-trained men. Fourteen men supplemented with 2224mg EPA+2208mg DHA and a placebo for 6 weeks in a random order, double blind cross-over design (with an 8 week washout) prior to performing a 60 minute treadmill climb using a weighted pack. Blood was collected pre and post exercise and analyzed for a variety of oxidative stress and inflammatory biomarkers. Blood lactate, muscle soreness, and creatine kinase activity were also measured. Result...
Source: Lipids in Health and Disease - August 18, 2009 Category: Lipidology Authors: Richard BloomerDouglas LarsonKelsey Fisher-WellmanAndrew GalpinBrian Schilling Source Type: journals

Isomer-specific effects of CLA on gene expression in human adipose tissue depending on PPARgamma2 P12A polymorphismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion these data suggested that the isomer specific influence of CLA on glucose and lipid metabolism is genotype dependent and at least in part mediated by PPARgamma.Trail registration www.controlled-trials.com: ISRCTN91188075 (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - August 17, 2009 Category: Lipidology Authors: Julia HerrmannDiana RubinRobert HaslerUlf HelwigMaria PfeufferAnnegret AuingerChristane LauePetra WinklerDoris BellStephan SchreiberJuergen Schrezenmeir Source Type: journals

Skeletal muscle structural lipids improve during weight-maintenance after a very low calorie dietary interventionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective was to investigate in a group of obese subjects the course in skeletal muscle phospholipid (SMPL) fatty acids (FA) during a 24-weeks weight maintenance program, which was preceded by a successful very low calorie dietary intervention (VLCD). Special focus was addressed to SMPL omega-3 FA, which is a lipid entity that influences insulin action. Methods: Nine obese subjects (BMI=35.7 +/- 1.0kg/m2), who had completed an 8 weeks VLCD (weight-loss=-9.7 +/- 1.6kg, P (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - August 12, 2009 Category: Lipidology Authors: Steen HaugaardAllan VaagHuiling MuSten Madsbad Source Type: journals

Effect of the dietary supplement Meltdown(R) on catecholamine secretion, markers of lipolysis, and metabolic rate in men and women: a randomized, placebo controlled, cross-over studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Ingestion of Meltdown(R) results in an increase in catecholamine secretion, lipolysis, and metabolic rate in young men and women, with a similar response for both sexes. Meltdown(R) may prove to be an effective intervention strategy for fat loss, assuming individuals are normotensive and their treatment is monitored by a qualified health care professional. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - August 4, 2009 Category: Lipidology Authors: Richard BloomerRobert CanaleMegan BlankenshipKelley HammondKelsey Fisher-WellmanBrian Schilling Source Type: journals

Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally-administered glycyrrhizic acid-treated ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Results from this study may imply that GA could counteract the development of visceral obesity and improve dyslipidaemia via selective induction of tissue LPL expression and a positive shift in serum lipid parameters respectively, and retard the development of IR associated with tissue steatosis. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - July 28, 2009 Category: Lipidology Authors: Wai Yen Alfred LimYoke Yin ChiaShih Yeen LiongSo Ha TonKhalid Abdul KadirSharifah Noor Akmal Syed Husain Source Type: journals

Protonated Nanostructured aluminosilicate reduces plasma cholesterol concentrations and atherosclerotic lesions in Apolipoprotein E deficient mice fed a High cholesterol and high fat dietEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, in this study, the effectivity of chronic administration of protonated NSAS material in reduction of plasma cholesterol levels and decrease in development of atherosclerotic lesions was demonstrated in Apo-E deficient mice model. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - July 27, 2009 Category: Lipidology Authors: Olena SivakJerry DarlingtonPavel GershkovichPanayiotis ConstantinidesKishor Wasan Source Type: journals

Metabolism of fatty acids and lipid hydroperoxides in human body monitoring with Fourier transform infrared spectroscopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The measurements of lip surface lipids with FTIR-ATR technique may advance the investigation of human lipid metabolism in situ non-invasively. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - July 23, 2009 Category: Lipidology Authors: Satoshi YoshidaQin-Zeng ZhangSyu SakuyamaSatoshi Matsushima Source Type: journals

Haptoglobin inhibits phospholipid transfer protein activity in hyperlipidemic human plasmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Haptoglobin is a plasma protein that scavenges haemoglobin during haemolysis. Phospholipid Transfer Protein (PLTP) transfers lipids from Low Density Lipoproteins (LDL) to High Density Lipoproteins (HDL). PLTP is involved in the pathogenesis of atherosclerosis which causes coronary artery disease, the leading cause of death in North America. It has been shown that Apolipoprotein-A1 (Apo-A1) binds and regulates PLTP activity. Haptoglobin can also bind to Apo-A1, affecting the ability of Apo-A1 to induce enzymatic activities. Thus we hypothesize that haptoglobin inhibits PLTP activity. This work tested the effect ...
Source: Lipids in Health and Disease - July 22, 2009 Category: Lipidology Authors: Ryan HendersonKishor WasanCarlos Leon Source Type: journals

Effects of cardiovascular lifestyle change on lipoprotein subclass profiles defined by nuclear magnetic resonance spectroscopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study evaluated changes in plasma lipoprotein profiles determined by nuclear magnetic resonance (NMR) spectroscopy in patients participating in a prospective, nonrandomized lifestyle modification program designed to reverse or stabilize progression of coronary artery disease (CAD) to improve our understanding of lipoprotein management in cardiac patients. Results: The lifestyle intervention was effective in producing significant changes in lipoprotein subclasses that contribute to CAD risk. There was a clear beneficial effect on the total number of LDL particles (-8.3%, p (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - June 28, 2009 Category: Lipidology Authors: David DecewiczDavid NeatrourAmy BurkeMary Jane HaberkornHeather PatneyMarina VernalisDarrell Ellsworth Source Type: journals

n-3 polyunsaturated fatty acids in milk is associate to weight gain and growth in premature infantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results suggest that the n-3 PUFA composition of milk may be considered an important predictor of weight gain and growth. Considering the advantages of n-3 LC-PUFA consumption on infant growth and visual function and its association with reduced incidence of premature birth, dietitians should advise pregnant women to increase their intake of foods high in n-3 LC-PUFA. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - June 25, 2009 Category: Lipidology Authors: Sandra Barboza TinocoRosely SichieriCecilia SettaAnibal MouraMaria Tavares do Carmo Source Type: journals

Sex-associated effect of CETP and LPL polymorphisms on postprandial lipids in familial hypercholesterolaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In conclusion, it seems that gender and TaqIB polymorphism of the cholesteryl ester transfer protein gene were both associated with the distribution of triglyceride values after oral fat tolerance test, only in subjects with a pathological response to oral fat tolerance test. Specifically, men carrying the B2 allele of the TaqIB polymorphism showed a higher postprandial triglyceride peak and a delayed return to basal values compared with women carrying B2. However, further investigations in larger populations are required to replicate and confirm these findings. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - June 25, 2009 Category: Lipidology Authors: Katherine AnagnostopoulouGenovefa KolovouPeggy KostakouConstantinos MihasGeorge HatzigeorgiouChristina MarvakiDimitrios DegiannisDimitri MikhailidisDennis Cokkinos Source Type: journals

Influence of conjugated linoleic acid on the porcine immune response and morbidity: a randomized controlled trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Conjugated linoleic acid (CLA) has diverse influences on the immune response in different experimental models. In the present study we investigated the effect of CLA feeding on inflammatory and immune responses in a piglet model. We studied the duration of this effect and possible detrimental effects of CLA feeding. After 12 weeks of CLA and control supplementation and washout, animals were sacrificed and parenchymal organs were histologically examined. Results: In activated peripheral mononuclear cells interferon-gamma was significantly (p=0.008) lower in the CLA group by the end of the feeding period. This ef...
Source: Lipids in Health and Disease - June 21, 2009 Category: Lipidology Authors: Tomaz MalovrhLidija KompanPolona JuntesBranka WraberAlenka Spindler-VeselDrago Kompan Source Type: journals

Fatty acid patterns early after premature birth, simultaneously analysed in mothers' food, breast milk and serum phospholipids of mothers and infants.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although dietary w3 FAs were insufficient in an unselected cohort of mothers of premature infants, breastfeeding resulted in increased levels of DHA in the premature infants at the expense of the mothers, suggesting a general need to increase dietary w3 FAs during pregnancy and lactation. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - June 9, 2009 Category: Lipidology Authors: Karl-Goran SabelCristina Lundqvist-PerssonElsa BonaMax PetzoldBirgitta Strandvik Source Type: journals

Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity, platelet-activating factor acetylhydrolase (PAF-AH) in leukocytes and body composition in healthy adultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) also known as serum platelet activating factor acetylhydrolase (PAF-AH) activity constitutes a novel risk marker for cardiovascular disease. Leukocytes constitute one main cellular source of circulating Lp-PLA2. The aim of the present study was to evaluate the association of both serum and leukocyte PAF-AH activities with fat distribution and lean tissue. One hundred healthy volunteers without cardiovascular disease history participated in this study (n=52 men, 44+/-13 years and n=48 women, 43+/-13 years). Body composition was assessed with dual-energy X-ray abs...
Source: Lipids in Health and Disease - June 5, 2009 Category: Lipidology Authors: Paraskevi DetopoulouTzortzis NomikosElizabeth FragopoulouDemosthenis PanagiotakosChristos PitsavosChristodoulos StefanadisSmaragdi Antonopoulou Source Type: journals

The effect of dietary red palm oil on the functional recovery of the ischaemic/reperfused isolated rat heart: the involvement of the PI3-Kinase signaling pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have previously shown that dietary red palm oil (RPO) supplementation improves functional recovery in hearts subjected to ischaemia/reperfusion-induced injury. Unfortunately, the cellular and molecular mechanisms responsible for this phenomenon are still poorly understood and no knowledge exists regarding the effects of RPO supplementation on the phosphoinositide 3-kinase (PI3-K) signaling pathway and apoptosis during ischaemia/reperfusion injury. Therefore, the aims of the present study were three fold: (i) to establish the effect of RPO on the functional recovery of the heart after ischaemia/reperfuion injury; (ii) to...
Source: Lipids in Health and Disease - May 29, 2009 Category: Lipidology Authors: Anna-Mart EngelbrechtLouise OdendaalEugene Du ToitKrisztina KupaiTamas CzontPeter FerdinandyJacques van Rooyen Source Type: journals

Is adiponectin associated with acute myocardial infarction in Iranian non obese patients?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Backgrounds: Adiponectin is an adipose tissue-derived mediator with significant anti-atherogenic properties. A few studies were done in acute phase of myocardial infarction especially in non obese patients. We design a study to investigate the association between adiponectin concentration and acute phase of myocardial infarction in non obese patients. Methods: This case-control study was done in Paymaneah Hospital (Jahrom, Iran) from Feb 2007 to May 2008. Plasma adiponectin levels were measured in 43 patients with acute myocardial infarction (mean age: 62.7+/- 13.3 years, male: 67.4%) at the first 24 hours of admission and...
Source: Lipids in Health and Disease - May 28, 2009 Category: Lipidology Authors: Mohammad ShojaieAbdoreza SotoodahGhafar Shafaie Source Type: journals

Mclk1+/- mice are not resistant to the development of atherosclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings indicate that although Mclk1 heterozygosity can extend lifespan of mice, it does not necessarily protect against atherosclerosis. Moreover, in the presence of hyperlipidemia and chronic inflammation, Mclk1 heterozygosity is incapable of extending lifespan. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - May 5, 2009 Category: Lipidology Authors: Bryan G Hughes and Siegfried Hekimi Source Type: journals

Effects of 9cis,11trans and 10trans,12cis CLA on osteoclast formation and activity from human CD14+ monocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: 9,11 CLA inhibits osteoclast formation and activity from human cells, suggesting that this isomer may prevent bone resorption in humans. Although 10,12 CLA did not significantly reduce osteoclast formation, it reduced osteoclast activity and cathepsin K and RANK expression, suggesting that this isomer may also affect bone resorption. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 29, 2009 Category: Lipidology Authors: Ilana Platt and Ahmed El-Sohemy Source Type: journals

Angiogenesis in the New Zealand obese mouse model fed with high fat dietEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Observed changes in the NZO mice on HF diet argue for the hyperglycemia related activation of angiogenesis, leading to the formation of pathological, immature network. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 6, 2009 Category: Lipidology Authors: Adriana Balwierz, Anna Polus, Urszula Razny, Lukasz Wator, Grzegorz Dyduch, Romana Tomaszewska, Stephan Scherneck, Hans Joost and Aldona Dembinska-Kiec Source Type: journals

Macrophage cholesterol efflux correlates with lipoprotein subclass distribution and risk of obstructive coronary artery disease in patients undergoing coronary angiographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Macrophage cholesterol efflux is inversely correlated with lipoprotein particle size and risk of CAD. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 6, 2009 Category: Lipidology Authors: Patrick Linsel-Nitschke, Henning Jansen, Zouhair Aherrarhou, Stefanie Belz, Bjorn Mayer, Fritz Huber, Werner Kremer, Hans-Robert Kalbitzer, Jeanette Erdmann and Heribert Schunkert Source Type: journals

Small and dense LDL in Familial Combined Hyperlipidemia and N291S polymorphism of the lipoprotein lipase geneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There is a predominance of small and dense LDL cholesterol particles in familial combined hyperlipidemia (FCH). The lipoprotein lipase gene could exert an influence in these circumstances. To study the relationship of pattern B LDL and lipids with N291S polymorphism of lipoprotein lipase (LPL) in FCH patients. Lipid profile, apolipoproteins, diameter of LDL and N291S polymorphism were determined in 93 patients with FCH and 286 individuals from the general population. FCH patients with N291S polymorphism showed a lower mean diameter of LDL. FCH patients with pattern B LDL showed higher concentrations of triglycerides, VLDL...
Source: Lipids in Health and Disease - March 31, 2009 Category: Lipidology Authors: Antonio Lopez, Maria M Jarabo, Maria L Martinez-Triguero, Maria Morales, Eva Sola, Celia Banuls, Marta Casado and Antonio Hernandez Source Type: journals

Increased body mass and depressive symptomatology are associated with hypercholesterolemia, among elderly individuals; results from the MEDIS studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Hypercholesterolemia is one of the most important factors causing cardiovascular disease (CVD). The aim of the present work was to evaluate the relationships between socio-demographic, clinical, lifestyle and depression status and the presence of hypercholesterolemia, among elderly individuals without known CVD. Methods: During 2005-2007, 1190 elderly (aged 65 to 100 years) men and women (from Cyprus, Mitilini, Samothraki, Cephalonia, Crete, Lemnos, Corfu and Zakynthos) were enrolled. Socio-demographic, clinical and lifestyle factors were assessed through standard procedures. Symptoms of depression were evalua...
Source: Lipids in Health and Disease - March 30, 2009 Category: Lipidology Authors: Stefanos Tyrovolas, Christos Lionis, Akis Zeimbekis, Vassiliki Bountziouka, Mary Micheli, Alexia Katsarou, Natassa Papairakleous, George Metallinos, Kornilia Makri, Evangelos Polychronopoulos and Demosthenes B. Panagiotakos Source Type: journals

Arachidonic acid increases matrix metalloproteinase 9 secretion and expression in human monocytic MonoMac 6 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study shows that of the PUFA studied, AA alone influences the expression of MMP-9, which might have implications in MMP-9 induced plaque rupture. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - March 30, 2009 Category: Lipidology Authors: Tiina Solakivi, Tarja Kunnas, Satu Karkkainen, Olli Jaakkola and Seppo T Nikkari Source Type: journals

Omega 3 fatty acids reduce myeloid progenitor cell frequency in the bone marrow of mice and promote progenitor cell differentiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results indicate that omega 3 fatty acids impact hematopoietic differentiation by reducing myeloid progenitor cell frequency in the bone marrow and promoting progenitor cell differentiation. Further exploration of this discovery could lead to the use of omega 3 fatty acids as a therapeutic option for patients that have various disorders of hematopoiesis. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - March 18, 2009 Category: Lipidology Authors: Melinda E Varney, W ELAINE Hardman and Vincent E Sollars Source Type: journals

Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Overall the findings reported in the present study lend further support to the potential of GLA as an inhibitor of glioma cell proliferation in vivo and show it has direct effects upon cell cycle control and angiogenesis. These effects involve changes in protein expression of VEGF, Flt1, ERK1, ERK2, MMP2, Cyclin D1, pRb, p53 and p27. Combination therapy using drugs with other, complementary targets and GLA could lead to gains in treatment efficacy in this notoriously difficult to treat tumour. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - March 17, 2009 Category: Lipidology Authors: Juliano ANDREOLI Miyake, Marcel Benadiba and Alison Colquhoun Source Type: journals

IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Irvingia gabonensis administered 150 mg twice daily before meals to overweight and/or obese human volunteers favorably impacts body weight and a variety of parameters characteristic of the metabolic syndrome. This is the first double blind randomized placebo controlled clinical trial regarding the anti-obesity and lipid profile modulating effects of an Irvingia gabonensis extract. The positive clinical results, together with our previously published mechanisms of gene expression modulation related to key metabolic pathways in lipid metabolism, provide impetus for much larger clinical studies. Irvingia gabonensi...
Source: Lipids in Health and Disease - March 2, 2009 Category: Lipidology Authors: Judith L Ngondi, Blanche C Etoundi, Christine B Nyangono, Carl MF Mbofung and Julius E Oben Source Type: journals

IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Irvingia gabonensis administered 150 mg twice daily before meals to overweight and/ or obese human volunteers favorably impacts body weight and a variety of parameters characteristic of the metabolic syndrome. This is the first double blind randomized placebo controlled clinical trial regarding the anti-obesity and lipid profile modulating effects of an Irvingia gabonensis extract. The positive clinical results, together with our previously published mechanisms of gene expression modulation related to key metabolic pathways in lipid metabolism, provide impetus for much larger clinical studies. Irvingia gabonens...
Source: Lipids in Health and Disease - March 2, 2009 Category: Lipidology Authors: Judith L Ngondi, Blanche C Etoundi, Christine B Nyangono, Carl MF Mbofung and Julius E Oben Source Type: journals

Novel Point Mutations Attenuate Autotaxin ActivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: H226Q-ATX and H434Q-ATX are the first point mutations of ATX/NPP2 demonstrated to differentially impair substrate hydrolysis, with hydrolysis of artificial substrates being disproportionately lower than that of LPC. This implies that H226 and H434 are important for substrate interaction. Assays that rely on hydrolyses of artificial substrates (FS-3 and pNpTMP), or that rely on hydrolysis of cell-derived substrate, might fail to detect certain mutated forms of ATX that are nonetheless capable of producing LPA in the presence of sufficient exogenous substrate. H420Q-ATX could not be differentiated from WT-ATX, i...
Source: Lipids in Health and Disease - February 17, 2009 Category: Lipidology Authors: Eunjin Koh, Russell W Bandle, David D Roberts, Mary L Stracke and Timothy Clair Source Type: journals

Role of MAPK in apolipoprotein CIII-induced apoptosis in INS-1E cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: It is suggested that elevated circulating apoCIII levels may contribute to beta-cell apoptosis via activation of p38 and ERK1/2 in individuals with T2DM. Therapies aiming at normalizing levels of apoCIII could be beneficial not only for the function of the beta-cell but also for cardiovascular protection. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - February 5, 2009 Category: Lipidology Authors: E-ri M Sol, Tea Sundsten and Peter Bergsten Source Type: journals

Endocannabinoids in Alzheimer's disease and their impact on normative cognitive performance: a case-control and cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Neuropathological, animal, and cell culture studies point to a role for the body's own endogenous cannabinoids (eCBs) system in Alzheimer's disease (AD) pathology and treatment. To date, no published studies have investigated the potential utility of circulating eCBs as diagnostic biomarkers for AD or the impact of central eCBs on cognition. Results: In comparison with healthy controls, there were no significant differences in measured eCB concentrations in plasma samples from patients with AD. Detectable eCBs in cerebrospinal fluid (CSF) had no relationship to cognitive performance in healthy controls at risk ...
Source: Lipids in Health and Disease - January 14, 2009 Category: Lipidology Authors: Jeremy Koppel, Heather Bradshaw, Terry E Goldberg, Houman Khalili, Philippe Marambaud, Michael J Walker, Miguel Pazos, Marc L Gordon, Erica Christen and Peter Davies Source Type: journals

Effects of probiotic bacteria , isoflavones and simvastatin on lipid profile and atherosclerosis in cholesterol-fed rabbits: a randomized double-blind studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The results indicated that probiotic microorganism E.faecium CRL 183 could be used to improve the lipid profile as an alternative or an adjuvant for drug therapy. The effectiveness of simvastatin in the management of blood lipid was confirmed. There were no effects of soy isoflavones, E. faecium and simvastatin on atherosclerosis development. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - January 7, 2009 Category: Lipidology Authors: Daniela CU Cavallini, Raquel Bedani, Laura Q Bomdespacho, Regina C Vendramini and Elizeu A Rossi Source Type: journals

Effects of a ferment soy product on the adipocyte area reduction and dyslipidemia control in hypercholesterolemic adult male ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The fermented soy product enriched with Enterococcus faecium and Lactobacillus Jugurti decreased circulating lipids levels and reduced adipocyte area in rats. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - December 16, 2008 Category: Lipidology Authors: Nadia Carla Cheik, Elizeu Antonio Rossi, Ricardo Luis Fernandes Guerra, Neuli Maria Tenorio, Claudia Maria Oller do Nascimento, Fabiana Pavan Viana, Marla Simone Jovenasso Manzoni, Iracilda Zeponni Carlos, Patricia Leao da Silva, Regina Celia Vendramini a Source Type: journals

Fat-to-glucose interconversion by hydrodynamic transfer of two glyoxylate cycle enzime genesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The glyoxylate cycle, which is well characterized in higher plants and some microorganisms but not in vertebrates, is able to bypass the citric acid cycle to achieve fat-to-carbohydrate interconversion. In this context, the hydrodynamic transfer of two glyoxylate cycle enzymes, such as isocytrate lyase (ICL) and malate synthase (MS), could accomplish the shift of using fat for the synthesis of glucose. Therefore, 20 mice weighing 23.37 +/- 0.96 g were hydrodinamically gene transferred by administering into the tail vein a bolus with ICL and MS. After 36 hours, body weight, plasma glucose, respiratory quotient and energy ex...
Source: Lipids in Health and Disease - December 10, 2008 Category: Lipidology Authors: P Cordero, J Campion, F I Milagro, F Marzo and J A Martinez Source Type: journals

Enhanced production of nitric oxide, reactive oxygen species, and pro-inflammatory cytokines in very long chain saturated fatty acid-accumulated macrophagesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggested that VLCSFA accumulation in macrophages may contribute to the pathogenesis of inflammatory diseases through the enhancement of inflammatory and oxidative responses. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - November 28, 2008 Category: Lipidology Authors: Naotake Yanagisawa, Kazunori Shimada, Tetsuro Miyazaki, Kume Atsumi, Yohei Kitamura, Katsuhiko Sumiyoshi, Takashi Kiyanagi, Takafumi Iesaki, Nao Inoue and Hiroyuki Daida Source Type: journals

A rapid 3% polyacrylamide slab gel electrophoresis method for high through put screening of LDL phenotypeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The rapid 3% polyacrylamide slab gel electrphoresis method developed is simple to perform, cost-effective and can be used for the identification LDL sub fractionation and phenotyping in large epidemiological studies. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - November 26, 2008 Category: Lipidology Authors: Yogendra Singh, Lakshmy Ramakrishnan, Ruby Gupta and Vemparala Kranthi Source Type: journals

Apolipoprotein gene polymorphisms and plasma levels in healthy Tunisians and patients with coronary artery diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Although APO (a) PNR, APO CI and APO CII genes are analyzed in only few populations, they show a frequency distribution, which is not at variance with that of APO E gene and other widely studied genetic markers. In the Tunisian population the APO E4 appears to be only indirectly involved in the severity of CAD. In the routine practice, in addition of classic parameters, it will be useful to measure the concentration of apo E and that of Homocysteine and if possible to determine the APO E gene polymorphism. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - November 17, 2008 Category: Lipidology Authors: Raoudha Bahri, Esther Esteban, Pedro Moral, Mohsen Hassine, Khaldoun Ben Hamda and Hassen Chaabani Source Type: journals

The influence of feeding linoleic, gamma-linolenic and docosahexaenoic acid rich oils on rat brain tumor fatty acids composition and fatty acid binding protein 7 mRNA expressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Dietary supplementation of DHA containing oil could be an effective way to increase levels of long chain n-3 fatty acids in brain tumors and this increase may be mediated partly by up-regulation of FABP7 expression. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - November 16, 2008 Category: Lipidology Authors: Javad Nasrollahzadeh, Fereydoun Siassi, Mahmood Doosti, Mohammad Reza Eshraghian, Fazel Shokri, Mohammad Hossein Modarressi, Javad Mohammadi-Asl, Khosro Abdi, Arash Nikmanesh and Seyed Morteza Karimian Source Type: journals