MMR (Measles,Mumps,Rubella) Vaccine This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest news and research items in this category.

MMRV vaccines unsafe in severe immunodeficiency, pregnancy
(Source: Reactions)
Source: Reactions - January 27, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

EMA issues Questions and Answers on review of monovalent and multivalent measles, mumps, rubella and/or varicella vaccines
Source: European Medicines Agency Area: News On 13 December 2012, the European Medicines Agency completed a review of the use of monovalent and multivalent measles, mumps, rubella and/or varicella vaccines (MMRV) during pregnancy and in patients with immune deficiencies. The Agency's Committee for Medicinal Products for Human Use (CHMP) concluded that these vaccines should continue to be avoided during pregnancy, but that inadvertent vaccination of pregnant women with measles-, mumps- and/or rubella-containing vaccines should not be a reason for termination of pregnancy. In addition MMRV should continue to be avoided in ...
Source: NeLM - News - December 14, 2012 Category: Drugs & Pharmacology Source Type: news

Febrile seizures and measles-mumps-rubella-varicella (MMRV) vaccine: What do primary care physicians think?
CONCLUSIONS: After receiving data regarding febrile seizure risk after MMRV, few physicians report they would recommend MMRV to a healthy 12-15-month-old child. PMID: 22975026 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 10, 2012 Category: Allergy & Immunology Authors: O'Leary ST, Suh CA, Marin M, the Vaccine Policy Collaborative Initiative Tags: Vaccine Source Type: research

Measles-Containing Vaccines and Febrile Seizures in Children Age 4 to 6 Years
CONCLUSIONS: This study provides reassurance that MMRV and MMR + V were not associated with increased risk of febrile seizures among 4- to 6-year-olds. We can rule out with 95% confidence a risk greater than 1 febrile seizure per 15 500 MMRV doses and 1 per 18 000 MMR + V doses. (Source: PEDIATRICS)
Source: PEDIATRICS - May 1, 2012 Category: Pediatrics Authors: Klein, N. P., Lewis, E., Baxter, R., Weintraub, E., Glanz, J., Naleway, A., Jackson, L. A., Nordin, J., Lieu, T., Belongia, E. A., Fireman, B. Tags: Infectious Disease & Immunity Article Source Type: research

Measles-Containing Vaccines and Febrile Seizures in Children Age 4 to 6 Years
This study provides reassurance that MMRV and separately administered MMR and varicella were not associated with increased risk of febrile seizures among 4- to 6-year-olds. (Read the full article) (Source: PEDIATRICS)
Source: PEDIATRICS - May 1, 2012 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research

MMRV booster shots not tied to seizures
NEW YORK (Reuters Health) - Although the combined vaccine against measles, mumps and chickenpox comes with a small risk of fever-related seizures in toddlers, a new study suggests that's not true in older children. (Source: Modern Medicine)
Source: Modern Medicine - April 11, 2012 Category: Journals (General) Source Type: news

No Seizure Risk from Measles Vaccine in Older Children
A large new study has ruled out concerns that children over 4 are at greater risk of seizures after getting a common measles-containing vaccine called MMRV. (Source: RWJF News Digest - Public Health)
Source: RWJF News Digest - Public Health - April 9, 2012 Category: American Health Source Type: news

No Rise in Seizure Risk With MMRV Booster Vaccine
(Source: eMedicineHealth.com)
Source: eMedicineHealth.com - April 2, 2012 Category: Journals (General) Source Type: news

No Rise in Seizure Risk With MMRV Booster Vaccine
Title: No Rise in Seizure Risk With MMRV Booster VaccineCategory: Health NewsCreated: 4/2/2012 11:00:00 AMLast Editorial Review: 4/2/2012 12:00:00 AM (Source: MedicineNet Kids Health General)
Source: MedicineNet Kids Health General - April 2, 2012 Category: Pediatrics Source Type: news

Measles Vaccines Not Associated With Febrile Seizure Risk Measles Vaccines Not Associated With Febrile Seizure Risk
A large study finds no significant increase in febrile seizures among children taking the combination MMRV vaccine compared with those taking MMR followed by a separate varicella vaccine. Medscape Medical News (Source: Medscape Pediatrics Headlines)
Source: Medscape Pediatrics Headlines - April 2, 2012 Category: Pediatrics Tags: Pediatrics News Source Type: news

MMRV Vaccine Does Not Increase Febrile Seizure Risk in 4- to 6-Year-Olds
(Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - April 2, 2012 Category: Primary Care Tags: Medical News Source Type: news

Prevaccination screening of health-care workers for immunity to measles, rubella, mumps, and varicella in a developing country: What do we save?
In conclusion, the screening of HCWs before vaccination continues to be advisable. (Source: Journal of Infection and Public Health)
Source: Journal of Infection and Public Health - April 1, 2012 Category: Global & Universal Authors: Emine Alp, Fatma Cevahir, Selma Gökahmetoglu, Hayati Demiraslan, Mehmet Doganay Tags: Original Articles Source Type: research

Development of a bead-based multiplex immunoassay for the simultaneously quantitative detection of IgG serum antibodies against Measles, Mumps, Rubella and Varicella Zoster.
In conclusion, the MMRV multiplex assay is a good alternative for the conventional ELISAs and suitable for use in serosurveillance and vaccine studies. PMID: 22237896 [PubMed - as supplied by publisher] (Source: Clinical and Vaccine Immunology)
Source: Clinical and Vaccine Immunology - January 11, 2012 Category: Allergy & Immunology Authors: Smits GP, van Gageldonk PG, Schouls LM, van der Klis FR, Berbers GA Tags: Clin Vaccine Immunol Source Type: research

Concomitant MMRV, Prevnar Safe for Healthy InfantsConcomitant MMRV, Prevnar Safe for Healthy Infants
Administering a child's first dose of the measles, mumps, rubella and varicella (MMRV) vaccine together with the pneumococcal vaccine is "highly immunogenic and generally well tolerated." Reuters Health Information (Source: Medscape Pediatrics Headlines)
Source: Medscape Pediatrics Headlines - December 6, 2011 Category: Pediatrics Tags: Pediatrics News Source Type: news

Concomitant MMRV, Prevnar safe for healthy infants
NEW YORK (Reuters Health) - Administering a child's first dose of the measles, mumps, rubella and varicella (MMRV) vaccine together with the pneumococcal vaccine is "highly immunogenic and generally well tolerated," a new study shows. (Source: Modern Medicine)
Source: Modern Medicine - December 5, 2011 Category: Journals (General) Source Type: news

Immunogenicity and Safety of MMRV and PCV-7 Administered Concomitantly in Healthy Children
This study found that both measles, mumps, rubella, and varicella and pneumococcal 7-valent conjugate vaccines could be administered concomitantly in healthy children 12 to 15 months of age without affecting the safety or the antibody response to any of the components of either vaccine. (Read the full article) (Source: PEDIATRICS)
Source: PEDIATRICS - December 1, 2011 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research

Immunogenicity and Safety of MMRV and PCV-7 Administered Concomitantly in Healthy Children
CONCLUSIONS: Concomitant administration of the MMRV and PCV-7 is highly immunogenic and generally well tolerated. Similar immune responses between the groups support concomitant administration of the MMRV and PCV-7 to healthy children 12 to 15 months of age. (Source: PEDIATRICS)
Source: PEDIATRICS - December 1, 2011 Category: Pediatrics Authors: Leonardi, M., Bromberg, K., Baxter, R., Gardner, J. L., Klopfer, S., Nicholson, O., Brockley, M., Trammel, J., Leamy, V., Williams, W., Kuter, B., Schodel, F. Tags: Infectious Disease & Immunity Articles Source Type: research

Vaccines in the News
It is not unusual for vaccines to make the news, but today there was news on a lot of different vaccine topics from the American Academy of Pediatrics. One study, "Immunogenicity and Safety of MMRV and PCV-7 Administered Concomitantly in Healthy Children," should reassure many parents who are worried about vaccines. The study, which will be printed in the December issue of Pediatrics, found that it was safe to give toddlers ProQuad (a vaccine that combines MMR and Varivax) and Prevnar at the same time. The researchers found this combination of shots to be well tolerated and "highly immunogenic" as just over 1,000 children...
Source: About.com Pediatrics - November 28, 2011 Category: Pediatrics Source Type: news

Antibody persistence for 3 years following two doses of tetravalent measles–mumps–rubella–varicella vaccine in healthy children
Conclusion: Immunogenicity of the combined MMRV vaccine was sustained 3 years post-vaccination. (208136/041/NCT00406211). Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00431-011-1569-4Authors Markus Knuf, Children’s Department of Pediatrics, University Medicine Hospital, Johannes Gutenberg-University, Langenbeckstrasse 1, 55101 Mainz, GermanyFred Zepp, Children’s Department of Pediatrics, University Medicine Hospital, Johannes Gutenberg-University, Langenbeckstrasse 1, 55101 Mainz, GermanyKlaus Helm, Pediatric Office, Detmold, GermanyHartwig Maurer, Pediatric Office, Salzburg, Aus...
Source: European Journal of Pediatrics - September 20, 2011 Category: Pediatrics Tags: European Journal of Pediatrics Source Type: research

Prevention of Varicella: Update of Recommendations for Use of Quadrivalent and Monovalent Varicella Vaccines in Children
Two varicella-containing vaccines are licensed for use in the United States: monovalent varicella vaccine (Varivax [Merck & Co, Inc, West Point, PA]) and quadrivalent measles-mumps-rubella-varicella vaccine (MMRV) (ProQuad [Merck & Co, Inc]). It is estimated from postlicensure data that after vaccination at 12 through 23 months of age, 7 to 9 febrile seizures occur per 10 000 children who receive the MMRV, and 3 to 4 febrile seizures occur per 10 000 children who receive the measles-mumps-rubella (MMR) and varicella vaccines administered concurrently but at separate sites. Thus, 1 additional febrile seizure is expe...
Source: PEDIATRICS - August 31, 2011 Category: Pediatrics Authors: Committee on Infectious Diseases Tags: Therapeutics & Toxicology From the American Academy of Pediatrics Source Type: research

Tetravalent meningococcal serogroups A, C, W-135 and Y conjugate vaccine is well tolerated and immunogenic when co-administered with measles-mumps-rubella-varicella vaccine during the second year of life: An open, randomized controlled trial.
This study has been registered at www.clinicaltrials.gov NCT00474266. PMID: 21443965 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - March 24, 2011 Category: Allergy & Immunology Authors: Vesikari T, Karvonen A, Bianco V, Van der Wielen M, Miller J Tags: Vaccine Source Type: research

New Vaccine Recommendations Offer Combined Benefits While Saving Children Two Extra Shots
Last week, Canada's National Advisory Committee on Immunization (NACI) issued several statements including its recommendations for the use of PRIORIX-TETRA™; the first, and at present, the only measles-mumps-rubella-varicella (MMRV) combivalent vaccine authorized for use in Canada. In a simultaneously issued statement, NACI has now recommended that all children receive a second dose of varicella vaccine at either 18 months or 4-6 years of age, which can be given in combination with the scheduled second dose of the Measles-Mumps-Rubella vaccine. Manufactured by GlaxoSmithKline Inc... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 28, 2010 Category: Consumer Health News Tags: Immune System / Vaccines Source Type: news

MMRV and Seizures [Health Agencies Update]
(Source: JAMA)
Source: JAMA - August 24, 2010 Category: Journals (General) Authors: Kuehn, B. M. Tags: Neurology, Seizures, Nonepileptic, Pediatrics, Neonatology and Infant Care, Public Health, Immunization, Drug Therapy, Adverse Effects Health Agencies Update Source Type: research

MMRV vaccine elevates risk of febrile seizures
(Source: Reactions)
Source: Reactions - July 22, 2010 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Detection of IgG-class antibodies to measles, mumps, rubella, and varicella-zoster virus using a multiplex bead immunoassay
This study evaluated the performance of the MMRV IgG AtheNA Multi-Lyte® assay using nonclinically characterized serum specimens submitted to our laboratory for routine MMRV IgG testing. Mumps (n = 492) or rubella (n = 500) IgG were initially tested by enzyme-linked fluorescent antibody (ELFA), whereas measles (n = 494) or varicella (n = 497) were analyzed by EIA. Each sample was also tested by the AtheNA Multi-Lyte assay. Discordant results were retested by the predicate method and the multiplex assay, with further discrepancies being arbitrated by a third test. Compared to EIA/ELFA for MMRV IgG, the AtheNA assay demonstr...
Source: Diagnostic Microbiology and Infectious Disease - July 21, 2010 Category: Microbiology Authors: Neelam Dhiman, Deborah J. Jespersen, Leonard O. Rollins, Julie A. Harring, Elaine M. Beito, Matthew J. Binnicker Tags: Virology Source Type: research

Measles-Mumps-Rubella-Varicella Combination Vaccine and the Risk of Febrile Seizures
CONCLUSIONS: Among 12- to 23-month-olds who received their first dose of measles-containing vaccine, fever and seizure were elevated 7 to 10 days after vaccination. Vaccination with MMRV results in 1 additional febrile seizure for every 2300 doses given instead of separate MMR + varicella vaccines. Providers who recommend MMRV should communicate to parents that it increases the risk of fever and seizure over that already associated with measles-containing vaccines. (Source: PEDIATRICS)
Source: PEDIATRICS - July 1, 2010 Category: Pediatrics Authors: Klein, N. P., Fireman, B., Yih, W. K., Lewis, E., Kulldorff, M., Ray, P., Baxter, R., Hambidge, S., Nordin, J., Naleway, A., Belongia, E. A., Lieu, T., Baggs, J., Weintraub, E., for the Vaccine Safety Datalink Tags: Articles Source Type: research

Combo MMRV Vaccine Tied to Higher Febrile Seizure Risk
Major Finding: In the 7- to10-day postvaccination period, use of MMRV was associated with 4.3 additional febrile seizures per 10,000 doses, compared with separate administration of MMR and varicella vaccine. (Source: Pediatric News)
Source: Pediatric News - June 30, 2010 Category: Journals (General) Authors: ROXANNA GUILFORD-BLAKE Tags: Infectious Diseases Source Type: news

Combination MMRV vaccine linked with two-fold risk of seizures, study finds
The combination vaccine for measles, mumps, rubella and chickenpox is associated with double the risk of febrile seizures for 1- to 2-year-old children compared with same-day administration of the separate vaccine for measles, mumps and rubella and the varicella vaccine for chicken pox. Funded by the US Centers for Disease Control, the study analyzed 459,000 children 1 to 2 years old from numerous health systems across the US receiving their first dose of measles-containing vaccine. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 29, 2010 Category: Science Source Type: news

Electronic Health Records Study Of 459,000 Children Sparked New CDC Recommendations Regarding Vaccine And Link To Seizures
“The combination vaccine for measles, mumps, rubella and chickenpox (MMRV) is associated with double the risk of febrile seizures for 1- to 2-year-old children compared with same-day administration of the separate vaccine for MMR (measles, mumps, rubella) and the varicella (V) vaccine for chicken pox, according to a Kaiser Permanente Division of Research study appearing [...] (Source: ICMCC: The International Council on Medical and Care Compunetics)
Source: ICMCC: The International Council on Medical and Care Compunetics - June 29, 2010 Category: Information Technology Authors: Lodewijk Tags: News Children Seizure Vaccine Source Type: news

Electronic Health Records Study Of 459,000 Children Sparked New CDC Recommendations Regarding Vaccine And Link To Seizures
The combination vaccine for measles, mumps, rubella and chickenpox (MMRV) is associated with double the risk of febrile seizures for 1- to 2-year-old children compared with same-day administration of the separate vaccine for MMR (measles, mumps, rubella) and the varicella (V) vaccine for chicken pox, according to a Kaiser Permanente Division of Research study appearing online in the journal Pediatrics. A febrile seizure is a brief, fever-related convulsion but it does not lead to epilepsy or seizure disorders, researchers explained. Funded by the U.S... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 29, 2010 Category: Consumer Health News Tags: Immune System / Vaccines Source Type: news

Vaccine Safety Data Show Risk Levels For Febrile Seizures After MMRV Vaccine
Researchers found a higher risk of febrile seizures 7 to 10 days after vaccination with Measles-Mumps-Rubella-Varicella combination vaccine (MMRV) compared to when MMR and varicella vaccines were given separately. Febrile seizures are seizures caused by a sudden spike in body temperature, and they are generally harmless... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 29, 2010 Category: Consumer Health News Tags: Immune System / Vaccines Source Type: news

Seizure Risk Rises With MMRV Vaccine
(Source: eMedicineHealth.com)
Source: eMedicineHealth.com - June 29, 2010 Category: Journals (General) Source Type: news

Childhood Combo-Vaccine Raises Risk of Seizures
(Ivanhoe Newswire) -- MMRV, the combination vaccine for measles, mumps, rubella and chickenpox, may double the risk of febrile seizures in 1- to 2-year-old children, compared with same-day administration of the vaccines as separate injections. (Source: Medical Headlines From Ivanhoe.com)
Source: Medical Headlines From Ivanhoe.com - June 29, 2010 Category: Consumer Health News Source Type: news

MMRV Vaccine Ups Fever and Seizure Risk
Measles-mumps-rubella-varicella vaccination is associated with an increased risk of fever and seizure in young children, above that already associated with measles-containing vaccines, according to research published online June 29 in Pediatrics, confirming preliminary evidence from a previous study. (Source: Modern Medicine)
Source: Modern Medicine - June 28, 2010 Category: Journals (General) Source Type: news

MMRV Doubles Risk for Febrile Seizures 7 to 10 Days After Vaccination
A new study suggests the vaccine causes 1 additional seizure for every 2300 doses with the combination vaccine, so the risk is still low, researchers note. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 28, 2010 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Seizure Risk Rises With 4-in-1 Vaccine
The risk of fever-related seizures in infants nearly doubles with the 4-in-1 measles-mumps-rubella-chickenpox vaccine (MMRV) compared to separate injections with the measles-mumps-rubella (MMR) vaccine and the chickenpox vaccine, according to a new study. (Source: WebMD Health)
Source: WebMD Health - June 28, 2010 Category: Consumer Health News Source Type: news

Electronic Medical Records Strengthen Vaccine Safety Monitoring In Seizure Study
“Intelligent use of electronic health records—even those collected from multiple health systems—can alert providers to harmful medical practices. That’s how Kaiser Permanente’s analysis of 459,000 pediatric health records revealed that young children who received the combo MMRV (measles, mumps, rubella, varicella) vaccine experienced twice the rate of febrile seizures as did children who received two separate [...] (Source: ICMCC: The International Council on Medical and Care Compunetics)
Source: ICMCC: The International Council on Medical and Care Compunetics - June 28, 2010 Category: Information Technology Authors: Lodewijk Tags: News Safety Source Type: news

MMRV vaccine associated with 2-fold risk of seizures
The combination vaccine for measles, mumps, rubella and chickenpox (MMRV) is linked to double the risk of febrile seizures for 1- to 2-year-old children compared with same-day administration of the separate vaccine for MMR (measles, mumps, rubella) and the varicella (V) vaccine for chicken pox, as per a Kaiser Permanente Division of Research study appearing online in the journal Pediatrics A febrile seizure is a brief, fever-related convulsion but it does not lead to epilepsy or seizure disorders, scientists explained........ (Source: Medicineworld.org: New Article Alert)
Source: Medicineworld.org: New Article Alert - June 28, 2010 Category: Consumer Health News Source Type: news

2 shots may be better than one for measles, mumps, rubella and chicken pox
A single vaccine of MMRV doubles the risk of fever-related seizures in children, a study finds. Children who receive a single vaccine that protects against measles, mumps, rubella and chicken pox appear to have an increased risk of fever-related seizures in the days after the shot than do children who receive two separate vaccinations. (Source: L.A. Times - Health)
Source: L.A. Times - Health - June 28, 2010 Category: Consumer Health News Source Type: news

2 shots may be better than one for measles, mumps, rubella and chicken pox
A single vaccine of MMRV doubles the risk of fever-related seizures in children, a study finds. Children who receive a single vaccine that protects against measles, mumps, rubella and chicken pox appear to have an increased risk of fever-related seizures in the days after the shot than do children who receive two separate vaccinations. (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - June 28, 2010 Category: Science Source Type: news

Combination MMRV vaccine linked with 2-fold risk of seizures
(Kaiser Permanente) The combination vaccine for measles, mumps, rubella and chickenpox is associated with double the risk of febrile seizures for 1- to 2-year-old children compared with same-day administration of the separate vaccine for measles, mumps and rubella and the varicella vaccine for chicken pox. Funded by the US Centers for Disease Control, the study analyzed 459,000 children 1 to 2 years old from numerous health systems across the US receiving their first dose of measles-containing vaccine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 28, 2010 Category: Global & Universal Source Type: news

Should We Consider Giving MMR Earlier?
DR. HARRISON is a professor of pediatrics and pediatric infectious diseases at Children's Mercy Hospitals and Clinics, Kansas City, Mo. Dr. Harrison disclosed he has received grant support from GlaxoSmithKline and Sanofi Pasteur Inc. for research on MMR and MMRV vaccines within the past 3 years. E-mail Dr. Harrison at pdnews@elsevier.com. (Source: Pediatric News)
Source: Pediatric News - May 31, 2010 Category: Journals (General) Authors: CHRISTOPHER J. HARRISON Tags: ID Consult Source Type: news

Bio-Rad Launches A Measles, Mumps, Rubella, And Varicella-Zoster Virus IgG Kit For Its BioPlex 2200 System
Bio-Rad Laboratories, Inc. (NYSE: BIO) and (NYSE: BIO.B), a multinational manufacturer and distributor of life science research and clinical diagnostic products, announced the launch of the BioPlex® 2200 MMRV IgG kit for use on the company's BioPlex® 2200 system. The MMRV IgG kit (measles; mumps; rubella; and the varicella-zoster virus, which is commonly known as chicken pox) provides simultaneous results for the four tests that are commonly ordered together to determine a patient's susceptibility to MMRV... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 25, 2010 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

CDC Updates Recommendations for MMRV Vaccination
Physicians who provide care for children should be aware that the CDC has published updated recommendations for vaccination against measles, mumps, rubella and varicella. The recommendations, which have been adopted by the AAFP, offer clinicians insight into the preferred use of combination measles, mumps, rubella and varicella, or MMRV, vaccine versus use of MMR vaccine plus varicella vaccine. (Source: AAFP Clinical Care and Research)
Source: AAFP Clinical Care and Research - May 12, 2010 Category: Primary Care Source Type: news

ACIP Issues New Guidelines for Use of Combination Measles, Mumps, Rubella, Varicella Vaccine
A MMWR report offers new recommendations for use of the MMRV vaccine adopted in June 2009 by the Centers for Disease Control and Prevention Advisory Committee on Immunization Practices. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 11, 2010 Category: Consumer Health News Tags: Allergy & Clinical Immunology Source Type: news

Use of combination measles, mumps, rubella, and varicella vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP).
This report presents new recommendations adopted in June 2009 by CDC's Advisory Committee on Immunization Practices (ACIP) regarding use of the combination measles, mumps, rubella, and varicella vaccine (MMRV, ProQuad, Merck & Co., Inc.). MMRV vaccine was licensed in the United States in September 2005 and may be used instead of measles, mumps, rubella vaccine (MMR, M-M-RII, Merck & Co., Inc.) and varicella vaccine (VARIVAX, Merck & Co., Inc.) to implement the recommended 2-dose vaccine schedule for prevention of measles, mumps, rubella, and varicella among children aged 12 months-12 years. At the time of its l...
Source: MMWR Recomm Rep - May 6, 2010 Category: Epidemiology Authors: Marin M, Broder KR, Temte JL, Snider DE, Seward JF, Tags: MMWR Recomm Rep Source Type: research

Safety, immunogenicity and immediate pain of intramuscular versus subcutaneous administration of a measles–mumps–rubella–varicella vaccine to children aged 11–21 months
This study compared intramuscular and subcutaneous administration of two doses of measles–mumps–rubella–varicella (MMRV) combination vaccine (Priorix-Tetra™, GlaxoSmithKline Biologicals) in children. Healthy children (N = 328) were randomised to receive MMRV either intramuscularly or subcutaneously. Reactogenicity was similar between treatment groups for immediate vaccination pain, vaccination site pain, redness and incidence of fever and rashes. Slightly less vaccination site swelling occurred during days 0–3 of the post-vaccination period after intramuscular administration. Seroconversion rates for all ...
Source: European Journal of Pediatrics - February 11, 2010 Category: Pediatrics Tags: European Journal of Pediatrics Source Type: research

ACIP, AAP support choice of MMRV or separate MMR, varicella vaccines [NEWS AND FEATURES]
(Source: AAP News)
Source: AAP News - January 1, 2010 Category: Pediatrics Authors: Kimberlin, D. W. Tags: NEWS AND FEATURES Source Type: research

A combined measles, mumps, rubella and varicella vaccine (Priorix-Tetra): Immunogenicity and safety profile.
Priorix-Tetra (GlaxoSmithKline Biologicals) is a combined measles, mumps, rubella and varicella (MMRV) vaccine. Eight studies involving more than 3000 children were reviewed. Compared with co-administration of MMR (Priorix) and varicella (Varilrix) vaccines, the MMRV vaccine showed: similar immunogenicity, with immunity shown up to 3 years post-vaccination; a higher rate of fever after the first dose; a slight increase in mild local reactions after the second dose. This MMRV vaccine can be used either as a two-dose vaccine or as a second dose in children primed with separate MMR and/or varicella vaccines, offering a co...
Source: Vaccine - August 5, 2009 Category: Allergy & Immunology Authors: Czajka H, Schuster V, Zepp F, Esposito S, Douha M, Willems P Tags: Vaccine Source Type: research