MMR (Measles,Mumps,Rubella) VaccineThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you your search results in order of date.

Pages: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20

991 records returned

Evidence That Nucleosomes Inhibit Mismatch Repair in Eukaryotic Cells [Dna: Replication, Repair, Recombination, and Chromosome Dynamics]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examines the interaction between human MutS and a mismatch located within a nucleosome or between two nucleosomes. The results show that, whereas MutS specifically recognizes both types of nucleosomal heteroduplexes, the protein bound the mismatch within a nucleosome with much lower efficiency than a naked heteroduplex or a heterology free of histone proteins but between two nucleosomes. Additionally, MutS displays reduced ATPase- and ADP-binding activity when interacting with nucleosomal heteroduplexes. Interestingly, nucleosomes block ATP-induced MutS sliding along the DNA helix when the mismatch is in between...
Source: Journal of Biological Chemistry - November 20, 2009 Category: Chemistry Authors: Li, F., Tian, L., Gu, L., Li, G.-M. Tags: Dna: Replication, Repair, Recombination, and Chromosome Dynamics Source Type: journals

Partial loss of heterozygosity events at the mutated gene in tumors from MLH1/MSH2 large genomic rearrangement carriersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: LGRs accounted for 25% of germline MMR mutations identified in 28 Slovakian HNPCC families. A high frequency of LGRs among the MSH2 mutations provides a rationale for a MLPA screening of the Slovakian HNPCC families prior scanning by DNA sequencing. LOH at part of the informative loci confined to the MLH1 or MSH2 gene (heterozygous LGR region, SNP, or microsatellite) is a novel finding and can be regarded as a partial LOH. The conversion begins within the gene, and the details of conversion tracts are discussed for each case. (Source: BioMed Central)
Source: BioMed Central - November 20, 2009 Category: Journals (General) Authors: Katarina ZavodnaTomas KrivulcikMaria Gerykova BujalkovaTomas SlamkaDavid MartinickyDenisa IlencikovaZdena Bartosova Source Type: journals

CKS topic review: MeaslesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: CKS Area: Evidence > Guidelines This Topic Review from the Clinical Knowledge Service (CKS) covers the management of acute measles and post-exposure prophylaxis for measles. This topic does not cover the prevention of measles with the combined measles, mumps, and rubella (MMR) vaccine. (Source: NeLM - Infections)
Source: NeLM - Infections - November 17, 2009 Category: Infectious Diseases Source Type: organizations

The use of nilotinib or dasatinib after failure to 2 prior tyrosine kinase inhibitors: long-term follow-upEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on 48 chronic myeloid leukemia patients sequentially treated with 3 TKIs: 34 with dasatinib after imatinib/nilotinib failure and 14 with nilotinib after imatinib/dasatinib failure. Before the third TKI, 25 patients were in chronic phase (CP), 10 in accelerated phase (AP), and 13 in blast phase (BP). Best response to third TKI in CP was 5 major molecular responses (MMR), 3 complete cytogenetic (CCyR), 2 partial cytogenetic (PCyR), 3 minor cytogenetic (mCyR), 6 complete hematologic responses (CHR), and 6 with no response (NR). In AP, 1 patient achieved MMR, 1 CCyR, 2 PCyR, 1 mCyR, 4 CHR, and 1 NR. In BP, 1 achieved...
Source: Blood - November 12, 2009 Category: Hematology Authors: Garg, R. J., Kantarjian, H., O'Brien, S., Quintas-Cardama, A., Faderl, S., Estrov, Z., Cortes, J. Tags: Free Research Articles, Myeloid Neoplasia, Clinical Trials and Observations Source Type: journals

Kinetics of antibody persistence following administration of a combination meningococcal serogroup C and Haemophilus influenzae type b conjugate vaccine at 12 to 15 months of age in healthy UK infants primed with two doses of one of three monovalent meningococcal serogroup C vaccines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The kinetics of antibody persistence following the administration of a combination meningococcal serogroup C and Haemophilus influenzae type b (Hib) conjugate vaccine (Menitorix) in the second year of life in children primed with two doses of one of three monovalent meningococcal serogroup C (MCC) vaccines was investigated. Study subjects were either administered Menitorix at 12 to 15 months of age followed by the 7-valent pneumococcal conjugate (PCV7) and measles, mumps and rubella (MMR) vaccine 4 to 6 weeks later or all three vaccines concomitantly at 12 to 15 months of age. Blood samples were collected before and 1,...
Source: Clinical and Vaccine Immunology - November 11, 2009 Category: Allergy & Immunology Authors: Borrow R, Andrews N, Findlow H, Waight P, Southern J, Crowley-Luke A, Stapley L, England A, Findlow J, Miller E Tags: Clin Vaccine Immunol Source Type: journals

Estrogens, MSI and Lynch syndrome-associated tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Estrogens play a major role in the biology of hormone-responsive tissues but also in the normal physiology of various non-typical hormone-responsive tissues. In disease, estrogens have been associated with tumor development, in particular with tumors such as breast, endometrium, ovary and prostate. In this paper we will review the molecular mechanisms by which estrogens are involved in cancer development, with a special focus in Lynch syndrome related neoplasia. Further, we discuss the role estrogens might have on cell proliferation and apoptosis, how estrogens metabolites can induce DNA damage and we discuss a possibl...
Source: Biochimica et Biophysica Acta - November 7, 2009 Category: Biochemistry Authors: Ferreira AM, Westers H, Albergaria A, Seruca R, Hofstra RM Tags: Biochim Biophys Acta Source Type: journals

Colorectal Cancer Due to Deficiency in DNA Mismatch Repair Function: A ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lynch syndrome (LS) is an autosomal dominant cancer predisposition syndrome attributable to deleterious germline mutations in mismatch repair (MMR) genes. The syndrome is typified by early-onset, frequently right-sided colorectal cancers (CRCs) with characteristic histologic features and tendency for multiplicity and an increased risk for extracolonic tumors at particular sites; it accounts for 1% to 5% of CRC. Deficient mismatch repair (dMMR) function manifests as immunohistochemically detectable absence of one or more MMR proteins and microsatellite instability (MSI). Approximately 15% of sporadic, noninherited CRC are c...
Source: Advances in Anatomic Pathology - October 30, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Families with germline MMR gene mutations had increased risk for pancreatic cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: HemOncToday.com)
Source: HemOncToday.com - October 28, 2009 Category: Cancer & Oncology Source Type: info

Assessing pathogenicity of MLH1 variants by co-expression of human MLH1 and PMS2 genes in yeastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Results of our in vivo yeast-based approach correlate well with clinical data in five out of seven hMLH1 variants and the described model was thus shown to be useful for functional characterization of MLH1 variants in cancer patients found throughout the entire coding region of the gene. (Source: BMC Cancer)
Source: BMC Cancer - October 28, 2009 Category: Cancer & Oncology Authors: Matjaz VogelsangAleksandra CominoNeja ZupanecPetra HudlerRadovan Komel Source Type: journals

ORIGINAL CONTRIBUTION: Risk of Pancreatic Cancer in Families With Lynch SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Among 147 families with germline MMR gene mutations, the risk of pancreatic cancer was increased compared with the US population. Individuals with MMR gene mutations and a family history of pancreatic cancer are appropriate to include in studies to further define the risk of premalignant and malignant pancreatic neoplasms and potential benefits and limitations of surveillance. (Source: JAMA)
Source: JAMA - October 27, 2009 Category: Journals (General) Authors: Kastrinos, F., Mukherjee, B., Tayob, N., Wang, F., Sparr, J., Raymond, V. M., Bandipalliam, P., Stoffel, E. M., Gruber, S. B., Syngal, S. Tags: Oncology, Colon Cancer, Oncology, Other, Gastroenterology, Gastrointestinal Diseases, Liver/ Biliary Tract/ Pancreatic Diseases, Genetics, Genetic Disorders Original Contribution Source Type: journals

Differential Cellular Responses to Prolonged LDR-IR in MLH1-Proficient and MLH1-Deficient Colorectal Cancer HCT116 Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: MLH1 status significantly affects cellular responses to prolonged LDR-IR. MLH1 may enhance cell radiosensitivity to prolonged LDR-IR through inhibition of homologous recombination (through inhibition of Rad51). (Clin Cancer Res 2009;15(22):OF1-9). PMID: 19861440 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - October 27, 2009 Category: Cancer & Oncology Authors: Yan T, Seo Y, Kinsella TJ Tags: Clin Cancer Res Source Type: journals

Microscopic magnetic resonance in congenital diaphragmatic hernia and associated malformations in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Microscopic magnetic resonance involves refined and expensive equipment but it provides a powerful research tool for the study of CDH and other malformations in rat fetuses. Further work on this area is warranted. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00383-009-2518-4Authors Montserrat Bret, Hospital Universitario La Paz Department of Radiology Madrid SpainAna Lourdes Luis, Hospital Universitario La Paz Department of Pediatric Surgery Paseo de la Castellana 261 28046 Madrid SpainEmilio Cuesta, Hospital Universitario La Paz Department of Radiology Madrid SpainFede...
Source: Pediatric Surgery International - October 23, 2009 Category: Surgery Tags: Pediatric Surgery International Source Type: journals

[Vaccination rate of premature infants at 6 and 24 months of age: A pilot study.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The vaccine practices do not follow the postnatal chronological age of the premature baby according to the schedule recommended for full-term infants and vaccination is begun late. Based on the CSHPF vaccination recommendations, nearly 7 premature infants out of 10 have an incomplete immunization status for DTPCoqHib, hepatitis B, and ROR at 2 years of age. According to the pertussis coverage observed in premature infants, the new recommendations on vaccination of the newborn's care giver and family should be completed before the infant's discharge from the hospital using a new acellular vaccine for adult immun...
Source: Archives de Pediatrie - October 23, 2009 Category: Pediatrics Authors: Pinquier D, Adde-Michela C, Ploin D, Levêque C, Marret S, Tags: Arch Pediatr Source Type: journals

Decline of hospital admissions for MMR vaccinations in children with egg allergyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - October 22, 2009 Category: Pediatrics Authors: Govindaraj, P, Alfaham, M, Davies, C, Tuthill, D Tags: PostScript Source Type: journals

Reporting of MMR evidence in professional publications: 1988-2007Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: While a period of neutrality may reflect a professional response to uncertainty by holding back until consensus emerges, it may also represent a missed opportunity to promote evidence-based practice. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - October 22, 2009 Category: Pediatrics Authors: Hilton, S, Hunt, K, Langan, M, Hamilton, V, Petticrew, M Tags: Dentistry and oral medicine Original articles Source Type: journals

Coding microsatellite instability analysis in microsatellite unstable small intestinal adenocarcinomas identifies MARCKS as a common target of inactivationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we herein present a cMSI profile of MSI-H small intestinal adenocarcinomas identifying MARCKS as a frequent target of mutation. Loss of MARCKS protein expression suggests a significant role of MARCKS inactivation in the pathogenesis of small intestinal adenocarcinomas. © 2009 Wiley-Liss, Inc. (Source: Molecular Carcinogenesis)
Source: Molecular Carcinogenesis - October 21, 2009 Category: Molecular Biology Authors: Sara Michel, Matthias Kloor, Sandhya Singh, Georg Gdynia, Wilfried Roth, Magnus von Knebel Doeberitz, Peter Schirmacher, Hendrik Bläker Source Type: journals

Establishing pathogenicity of germline mismatch repair gene mutations: A Bayesian modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An increasing problem in diagnostic molecular genetics is establishing the pathogenicity of mutations. It is therefore fortunate that in Lynch Syndrome data from the analysis of tumours can provide evidence for or against pathogenicity. Testing tumours for microsatellite instability and immunohistochemical changes in protein expression is now in almost routine use, but how confident can one be that these findings are evidence for or against pathogenicity? Attempts are being made to address the general issue of interpretation through e.g. IARC [Plon SE et al. Hum Mutat. (2008) 29(11):1282-91.], the UK Clinical Molecular Gen...
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Ian Frayling, E. Sheridan, D. Eccles Tags: Abstracts Source Type: journals

Ongoing rubella outbreak in Bosnia and Herzegovina, March-July 2009--preliminary report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Between 24 March and 31 July 2009, 342 clinically diagnosed cases of rubella were notified in five municipalities in Republika Srpska, Bosnia and Herzegovina. Fourteen cases were laboratory-confirmed by positive IgG against rubella virus. Four virus isolates were obtained and identified as genotype 2B strains, with one isolate differing by a single mutation in the region of the E1 gene. This ongoing outbreak revealed gaps in the immunisation programme during the war in BiH (1992-1995) and highlights the need to revise legislation to permit immunisation of children above 14 years of age with measles, mumps, rubella (MMR...
Source: Euro Surveill - October 11, 2009 Category: Infectious Diseases Authors: Novo A, Huebschen JM, Muller CP, Tesanovic M, Bojanic J Tags: Euro Surveill Source Type: journals

Clinical and histomolecular endometrial tumor characterization of patients at-risk for Lynch syndrome in South of BrazilEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Lynch syndrome is an autosomal dominant cancer predisposition syndrome caused by germline mutations in one of the mismatch repair (MMR) genes: MLH1, MSH2, MSH6 and PMS2. Clinically, Lynch syndrome is characterized by early onset (45 years) of colorectal cancer (CRC), as well as extra-colonic cancer. Male and female carriers of Lynch syndrome-associated mutations have different lifetime risks for CRC and in women endometrial cancer (EC) may be the most common tumor. Whenever Amsterdam criteria are not fulfilled, the currently recommended laboratory screening strategies involve microsatellite ins...
Source: Familial Cancer - October 11, 2009 Category: Cancer & Oncology Tags: Familial Cancer Source Type: journals

A novel interaction between human DNA polymerase eta and MutLalpha.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human DNA polymerase eta (Poleta) is the gene product underlying xeroderma pigmentosum variant, and plays principal roles in translesion DNA synthesis. Here, we identified human MLH1, an essential component of mismatch repair (MMR), as a Poleta-interacting protein. The middle area residues, which include the little finger domain, of Poleta are important for the interaction with MLH1. Poleta also interacts with the MLH1/PMS2 heterodimer (MutLalpha). Co-immunoprecipitation analyses revealed that MutLalpha, and also MSH2 and MSH6, components of the MutSalpha heterodimer, form complexes with Poleta in human cells. Although...
Source: Biochemical and Biophysical Research communications - October 10, 2009 Category: Biochemistry Authors: Kanao R, Hanaoka F, Masutani C Tags: Biochem Biophys Res Commun Source Type: journals

Childhood Vaccines And Autism: No Scientific Link FoundEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new article recently published in the Journal for Specialists in Pediatric Nursing explored vaccination history, vaccine safety monitoring systems in the U.S., and the two most publicized theoretical vaccine-related exposures associated with autism - the vaccine preservative thimerosal and the measles, mumps, and rubella (MMR) vaccine. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 10, 2009 Category: Consumer Health News Tags: Autism Source Type: news

Historical Data Shows Vaccines are Not what Saved UsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) With all of the hype surrounding the H1N1 swine flu virus lately, everyone is very concerned with the safety and effectiveness of vaccines, and rightly so. This is a very important question that we must all ask ourselves and find out what the truth is. As the debate rages on an even more important question has rarely been asked. Do vaccines even protect you from the viruses and illnesses that they claim to?If you only get your news and information from mainstream news and educational sources, then the question about whether vaccines are effective is never even raised. This lack of discussion give the percepti...
Source: NaturalNews.com - October 9, 2009 Category: Consumer Health Advice Source Type: news

GSK expands presence in China through strategic cooperationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
GlaxoSmithKline (GSK) and Jiangsu Walvax Biotech Company (Walvax) have announced a cooperation agreement to form a long-term Joint Venture (JV) to develop and manufacture paediatric vaccines for use in China. The JV will produce vaccines for measles, mumps, and rubella (MMR) (Priorix™) and potentially other paediatric vaccines. GSK will also transfer the technology to enable the JV to manufacture the vaccines locally over time. (Source: World Pharma News)
Source: World Pharma News - October 6, 2009 Category: Pharmaceuticals Source Type: news

Analysis of microsatellite instability in medulloblastomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study is the most comprehensive analysis of MSI in medulloblastomas to date. We observed the presence of MSI together with mutations of MSI target genes in a small fraction of cases, suggesting a new genetic pathway for a role in medulloblastoma development. (Source: Neuro-Oncology)
Source: Neuro-Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Viana-Pereira, M., Almeida, I., Sousa, S., Mahler-Araujo, B., Seruca, R., Pimentel, J., Reis, R. M. Tags: Basic and Translational Investigations Source Type: journals

Analysis of candidate target genes for mononucleotide repeat mutation in microsatellite instability-high (MSI-H) endometrial cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we analyzed mutations in 11 cancer-related genes with mononucleotide repeats susceptible to MSI in a coding region [hMSH3 (A8), hMSH6 (C8), TGF-beta RII (A10), MBD4 (A10), BAX (G8), PTEN (A6 in exon 7), HDAC2 (A9), EPHB2 (A9), Caspase-5 (A10), TCF-4 (A9) and Axin2 (G7)] in 22 patients with MSI-H sporadic endometrial cancer. Mutations in hMSH6 (C8) and TGF-beta RII (A10) were found most frequently, at rates of 36.3% (8/22) each. Mutations of BAX (G8) and TCF-4 (A9), which are common in MSI-positive colorectal cancer, occurred at rates of 22.7 and 0%, respectively, which suggests that the MSI target gene may d...
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Kawaguchi M, Banno K, Yanokura M, Kobayashi Y, Kishimi A, Ogawa S, Kisu I, Nomura H, Hirasawa A, Susumu N, Aoki D Tags: Int J Oncol Source Type: journals

Ongoing rubella outbreak in Bosnia and Herzegovina, March-July 2009 - preliminary reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Between 24 March and 31 July 2009, 342 clinically diagnosed cases of rubella were notified in five municipalities in Republika Srpska, Bosnia and Herzegovina. Fourteen cases were laboratory-confirmed by positive IgG against rubella virus. Four virus isolates were obtained and identified as genotype 2B strains, with one isolate differing by a single mutation in the region of the E1 gene. This ongoing outbreak revealed gaps in the immunisation programme during the war in BiH (1992-1995) and highlights the need to revise legislation to permit immunisation of children above 14 years of age with measles, mumps, rubella (MMR) va...
Source: Eurosurveillance latest news - October 1, 2009 Category: Infectious Diseases Source Type: journals

Microsatellite instability is a common finding in multiple myeloma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Although our case number is small, probably the genomic instability in heavy-chain MM may be a common finding and probably plays a critical role in the MM pathogenesis. PMID: 19858056 [PubMed - in process] (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - October 1, 2009 Category: Cancer & Oncology Authors: Timurağaoğlu A, Demircin S, Dizlek S, Alanoğlu G, Kiriş E Tags: Clin Lymphoma Myeloma Source Type: journals

The hMSH2 and hMLH1 Genes in Hereditary Nonpolyposis Colorectal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the history of HNPCC, its clinical features, gene discovery, development of clinical genetic workup, and clinical surveillance, with an emphasis on the two major HNPCC genes, hMSH2 and hMLH1. It is not always possible to discuss these specific genes without commenting on the broader problem of HNPCC diagnosis and management. (Source: Surgical Oncology Clinics of North America)
Source: Surgical Oncology Clinics of North America - September 29, 2009 Category: Surgery Authors: Patrick M. Lynch Source Type: journals

Familial Colorectal Cancer Type X: The Other Half of Hereditary Nonpolyposis Colon Cancer SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Establishing the Amsterdam criteria, based on pedigrees, was essential for defining hereditary nonpolyposis colorectal cancer (HNPCC) syndrome in such a way that the underlying genetic cause could be identified. It is now known that about half of families that fulfill the original Amsterdam criteria have a hereditary DNA mismatch repair (MMR) gene mutation. These families may be said to have Lynch syndrome. The other half of families with HNPCC has no evidence of DNA MMR deficiency, and studies show that these families are different from families with Lynch syndrome. Familial colorectal cancer type X is the name used to re...
Source: Surgical Oncology Clinics of North America - September 29, 2009 Category: Surgery Authors: Noralane M. Lindor Source Type: journals

High-Dose Imatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia: High Rates of Rapid Cytogenetic and Molecular Responses [Hematologic Malignancies]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This study suggests that imatinib 400 mg twice a day results in more rapid reduction in tumor burden than imatinib 400 mg/d with minimal added toxicity. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - September 28, 2009 Category: Cancer & Oncology Authors: Cortes, Kantarjian, Goldberg, Powell, Giles, Wetzler, Akard, Burke, Kerr, Saleh, Salvado, McDougall, Albitar, Radich Tags: Clinical Trials, Chemotherapy Hematologic Malignancies Source Type: journals

Early loss of measles antibodies after MMR vaccine among HIV-infected adults receiving HAART.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The initial humoral immune response to measles vaccine was not different between HIV-infected adults and HIV-uninfected adults. However, HIV-infected adults have a rapid decline of measles antibodies despite their high CD4+ cell count and sustained cellular proliferative response. PMID: 19799846 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 28, 2009 Category: Allergy & Immunology Authors: Belaunzarán PF, García-León ML, Wong-Chew RM, Villasís-Keever A, Cuellar-Rodríguez J, Mosqueda-Gómez JL, Muñoz-Trejo T, Escobedo K, Santos JI, Ruiz-Palacios GM, Sierra-Madero JG Tags: Vaccine Source Type: journals

Behind the headlines - MMR jab has not raised autismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
'Behind the headlines' is produced by the NHS Knowledge Service and provides an unbiased and evidence-based analysis of health stories that make the news. Health stories that make the headlines are analysed and presented with the following details: Where did the story come from? What kind of scientific study was this? What were the results of the study? What interpretations did the researchers draw from these results? What does the NHS Knowledge Service make of this study? (Source: Neurological Conditions Specialist Library)
Source: Neurological Conditions Specialist Library - September 28, 2009 Category: Neurology Source Type: organizations

When Does the Rash of Roseola Occur?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion Rashes, particularly ones caused by viruses, are common presenting problems. In his first edition of Pediatrics, Dr. Rotch spent 72 pages describing infectious exanthemata. The cause of the exanthemata was unknown at the time, and thankfully many of those that he wrote of have been eradicated (smallpox), have effective vaccines to prevent (measles, rubella, varicella) or effective antibiotics for treatment (streptococcus). Dr. Rotch ends his extensive treatise with a table describing “the chief points of differential diagnosis in the exanthemata.” This is what was state-of-the-art in 1896 with his s...
Source: PediatricEducation.org - September 28, 2009 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: info

Joining the dots: a plea for precise estimates of the maternal mortality ratio in sub-Saharan Africa.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Monitoring of maternal mortality levels in sub-Saharan Africa (SSA) to assess the achievements of safe motherhood programmes and for MDG-5 has been made difficult because of the lack of precise estimates of the maternal mortality ratio (MMR). Projections based on the slow rate of decline of the MMR indicate that MDG-5 may not be reached before the end of this century in this region. Measurements done using demographical and health surveys, statistical modelling and censuses are imprecise and do not allow trends in individual countries to be established. SSA countries should be encouraged to measure mortality levels fro...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - September 26, 2009 Category: OBGYN Authors: Munjanja SP Tags: BJOG Source Type: journals

Recognition of O6MeG Lesions by MGMT and Mismatch Repair Proficiency may be a Prerequisite for Low-Dose Radiation Hypersensitivity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Low-dose hyper-radiosensitivity (HRS) is the phenomenon whereby cells exposed to radiation doses of less than approximately 0.5 Gy exhibit increased cell killing relative to that predicted from back-extrapolating high-dose survival data using a linear-quadratic model. While the exact mechanism remains to be elucidated, the involvement of several molecular repair pathways has been documented. These processes in turn are also associated with the response of cells to O6-methylguanine (O6MeG) lesions. We propose a model in which the level of low-dose cell killing is determined by the efficiency of both pre-replica...
Source: Radiation Research - September 25, 2009 Category: Physics Authors: Martin L, Marples B, Coffey M, Lawler M, Hollywood D, Marignol L Tags: Radiat Res Source Type: journals

Association of common variants in mismatch repair genes and breast cancer susceptibility: a multigene study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: It is possible that some of these common variants in MMR genes contribute significantly to breast cancer susceptibility. However, further studies with a large sample size will be needed to support our results. (Source: BMC Cancer)
Source: BMC Cancer - September 24, 2009 Category: Cancer & Oncology Authors: Joao CondeSusana SilvaAna AzevedoValdemar TeixeiraJulieta Esperanca PinaJose RueffJorge Gaspar Source Type: journals

More MMR vaccinations needed: NICEEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A greater number of young people need vaccinating against MMR if the UK is to achieve herd immunity, according to new guidance (Source: Nursing in Practice)
Source: Nursing in Practice - September 24, 2009 Category: Nursing Source Type: news

MMR autism link discredited by NHS researchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The link between MMR and autism has been further discredited by research findings that at least one in every 100 adults has a form of autism, a near identical rate to that in children (Source: Nursing Times Breaking News)
Source: Nursing Times Breaking News - September 23, 2009 Category: Nursing Source Type: news

MMR jab has not raised autismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report provides further evidence that adds to the many studies showing no link between MMR and autism. These findings will be welcomed by parents, doctors and many others who have been involved in investigating the controversial link first suggested by Dr Andrew Wakefield in 1998. Links To The Headlines Autism poll eases MMR jab concern. Daily Mirror, September 23 2009 Autism just as common in adults, so MMR jab is off the hook. The Guardian, September 23 2009 National Autistic Society comes off the fence: MMR isn't linked to autism. The Times, September 23 2009 Autism rates back MMR jab safety. BBC News, September 2...
Source: NHS News Feed - September 23, 2009 Category: Consumer Health News Tags: Medication Medical practice Source Type: news

MMR and hepatitis B vaccines must increaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NHS vaccination programmes against measles and hepatitis B in the under-19 age group must be expanded, says the NICE. (Source: Nursing Times Breaking News)
Source: Nursing Times Breaking News - September 23, 2009 Category: Nursing Source Type: news

MMR jabs 'not to blame for autism'Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NEW research into rates of autism in adults has dispelled any links between the condition and the MMR jab. (Source: Scotsman.com News - Health)
Source: Scotsman.com News - Health - September 22, 2009 Category: Consumer Health News Source Type: news

NICE costing template on reducing the differences in uptake of immunisations in children and young peopleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: NICE Area: News The costing statement accompany the NICE public health guidance on reducing the differences in uptake of immunisations in children and young people notes that the national resources required to implement the recommendations made cannot be quantified. Many public sector organisations already have strategies, policies and procedures in place to support immunisation programmes and should be able to implement the recommendations using existing resources. The government already funds immunisation programmes and the Department of Health has made additional funding available for mea...
Source: NeLM - Immunology and vaccination - September 22, 2009 Category: Allergy & Immunology Source Type: organizations

Paper round: WednesdayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Assisted suicide laws to be clarified, average Brits sexual encounters, and moreRelated items from OnMedicaHealth services must make better use of patient informationOlder doctors more likely to face performance probesWorld-first study rules out MMR link to autismPublic smoking bans cut heart attacks by one thirdNHS and psychiatric patients benefit from jobs scheme (Source: OnMedica Latest News)
Source: OnMedica Latest News - September 22, 2009 Category: UK Health Source Type: news

DNA mismatch repair (MMR)-dependent 5-fluorouracil cytotoxicity and the potential for new therapeutic targetsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The metabolism and efficacy of 5-fluorouracil (FUra) and other fluorinated pyrimidine (FP) derivatives have been intensively investigated for over fifty years. FUra and its antimetabolites can be incorporated at RNA- and DNA-levels, with RNA level incorporation provoking toxic responses in human normal tissue, and DNA-level antimetabolite formation and incorporation believed primarily responsible for tumour-selective responses. Attempts to direct FUra into DNA-level antimetabolites, based on mechanism-of-action studies, have led to gradual improvements in tumour therapy. These include the use of leukovorin to stabilize the...
Source: British Journal of Pharmacology - September 22, 2009 Category: Drugs & Pharmacology Authors: Long Shan Li, Julio C Morales, Martina Veigl, David Sedwick, Sheldon Greer, Mark Meyers, Mark Wagner, Richard Fishel, David A Boothman Source Type: journals

Autism rates back MMR jab safetyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Latest autism figures should dispel any fears about the MMR jab being linked to the condition, say experts. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - September 22, 2009 Category: Consumer Health News Tags: Health Source Type: news

World-first study rules out MMR link to autismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rates of autism broadly the same before and after advent of MMRRelated items from OnMedicaWHO to help in fight against a global flu pandemicDrinks industry must come clean on alcohol labellingPrevention screening for one third of populationAlcohol tax will cut consumption, say doctorsQuitting smoking improves child temperament (Source: OnMedica Latest News)
Source: OnMedica Latest News - September 21, 2009 Category: UK Health Source Type: news

Detection of group B rotavirus in an adult with acute gastroenteritis in Yangon, MyanmarEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In Yangon, Myanmar, a human group B rotavirus was first detected in 2007 in a stool specimen from a sporadic case of acute gastroenteritis in an adult. The strain was designated as MMR-B1. The full-length sequences of the MMR-B1 genes encoding VP7, VP4 (VP5* and VP8*), VP6, and NSP4 were determined for genetic characterization. These four MMR-B1 genes showed considerable higher sequence identities (97.2-98.4%) to those of group B rotaviruses detected in India (CAL-1 in 1998) and Bangladesh (Bang373 and Bang544 in 2000 and 2001, respectively) than to those of Chinese strains (90.7-93.6%) (ADRV and WH-1 in 1982 and 2002, res...
Source: Journal of Medical Virology - September 21, 2009 Category: Virology Authors: Tin Sabai Aung, Nobumichi Kobayashi, Shigeo Nagashima, Souvik Ghosh, Meiji Soe Aung, Khin Yi Oo, Ne Win Tags: Research Article Source Type: journals

National, state, and local area vaccination coverage among adolescents aged 13-17 years--United States, 2008.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report summarizes results from the 2008 NIS-Teen and, for the first time, includes estimates for each of the 50 states and selected local areas. Nationally, vaccination coverage for the three most recently recommended adolescent vaccinations and one childhood vaccination increased from 2007 to 2008: MCV4 (from 32.4% to 41.8%), Tdap (from 30.4% to 40.8%), >/=1 dose of HPV4 (from 25.1% to 37.2%), and >/=2 doses of VAR among those without disease history (from 18.8% to 34.1%). However, substantial variability in vaccination coverage was observed in 2008 among state and local areas and by race/ethnicity and poverty ...
Source: MMWR Morb Mortal Wkl... - September 17, 2009 Category: Epidemiology Tags: MMWR Morb Mortal Wkly Rep Source Type: journals

'Safe' blood lead levels affect children’s developmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Call for 'safe' blood lead threshold to be halved from 10 µg/dl to 5 µg/dl Related items from OnMedicaDoctors alerted to rabies risk after case reported in FranceFears over MMR vaccine still threaten epidemic Two in five autism cases may go undiagnosedNo benefit to add on asthma therapy in childrenHospitals told they need to improve services for children (Source: OnMedica Latest News)
Source: OnMedica Latest News - September 16, 2009 Category: UK Health Source Type: news

Evaluating Lynch syndrome in very early onset colorectal cancer probands without apparent polyposisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract To characterize the frequency of germline mutations associated with Lynch syndrome and review the potential expanded differential diagnoses in very early onset colorectal cancer (CRC) cases without apparent polyposis. Retrospectively reviewed medical records of 96 probands with CRC diagnosed prior to age 36 from three cancer centers. Determined the frequency of germline mutations in probands meeting different clinical criteria used to identify Lynch syndrome. Three of 46 (6.5%) single case indicators (probands without additional personal or family history suspicious for Lynch syndrome) were identifi...
Source: Familial Cancer - September 16, 2009 Category: Cancer & Oncology Tags: Familial Cancer Source Type: journals