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Community-acquired methicillin-resistant <i>Staphylococcus aureus</i> pyomyositis with myelitis: A rare occurrence with diverse presentation
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Kulkarni Girish Baburao, Pal P K, Veena Kumari H B, Goyal M, Kovoor J.M.E, Nadig Savitha, Arakere GayathriNeurology India 2009 57(5):653-656Staphylococcus aureus is the most common bacterial pathogen implicated in pyomyositis. There are increasing reports of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections. The present case report brings out the diverse clinical manifestations of MRSA infection in the form of paraspinal pyomyositis, myelitis, spinal osteomyelitis, and pneumonia. Molecular typing of the organism confirmed the diagnosis. Patient was successfully treated with vancomycin and ...
Source: Neurology India - November 20, 2009 Category: Neurology Authors: Kulkarni Girish Baburao, Pal P K, Veena Kumari H B, Goyal M, Kovoor J.M.E, Nadig Savitha, Arakere Gayathri Source Type: journals
Bacteremic methicillin-resistant Staphylococcus aureus deep neck abscess in a newborn—Case report and review of literatureEmail this article to a colleague.
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We describe an unusual localization of methicillin-resistant Staphylococcus aureus infection (MRSA) in a very young newborn. A 3-week-old male infant was admitted with fever, irritability, sialorrhea and stiffed left neck. The ENT examination revealed a deep neck mass and an ultrasound examination showed diffuse swelling of the left latero-pharyngeal area. A CT examination confirmed a deep neck abscess with difficult-to-define borders. Blood and nasopharyngeal cultures returned positive for MRSA. Treatment was started with intravenous teicoplanin and continued for 14 days with a marked decrease in abscess's dimensions and ...
Source: International Journal of Pediatric Otorhinolaryngology - November 20, 2009 Category: ENT & OMF Authors: Oana Falup-Pecurariu, Eugene Leibovitz, Carmen Pascu, Cristian Falup-Pecurariu Tags: Case reports Source Type: journals
New Chemical May Play Key Role In Hospital Superbugs' Battle, UKEmail this article to a colleague.
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A new chemical compound that mimics the body's ability to fight bacteria could help target hospital-acquired infections such as MRSA and C.difficile. The compound, which could be added to detergents or used as a coating for hospital equipment, is able to trap and release the gas nitric oxide - which is also produced by our own immune systems to kill bugs. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: MRSA / Drug Resistance Source Type: news
New Chemical May Play Key Role In Hospital Superbugs' Battle, UKEmail this article to a colleague.
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A new chemical compound that mimics the body's ability to fight bacteria could help target hospital-acquired infections such as MRSA and C.difficile. The compound, which could be added to detergents or used as a coating for hospital equipment, is able to trap and release the gas nitric oxide - which is also produced by our own immune systems to kill bugs. (Source: MRSA / Drug Resistance News From Medical News Today)
Source: MRSA / Drug Resistance News From Medical News Today - November 20, 2009 Category: Drugs & Pharmacology Tags: MRSA / Drug Resistance Source Type: news
Synthesis and Antistaphylococcal Activity of N-Substituted-1H-benzimidazole-sulphonamidesEmail this article to a colleague.
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A series of N-substituted-1H-benzimidazole-5(6)-sulfonamides and 3-(5,6-dichloro-1H-benzimidazol-2-yl)-N-substituted benzensulfonamides were synthesized and evaluated for antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). Certain compounds inhibit bacterial growth with low MIC ([mu]g/mL) values. The most active compounds 30, 31, and 32 have the lowest MIC values with 0.39 to 0.19 [mu]g/mL. Among the compounds having sulfonamido moities, 16, 23, and 24 exhibited the strongest antibacterial activity with 1.56 [mu]g/mL MIC values. (Source: Archiv der Pharmazie)
Source: Archiv der Pharmazie - November 20, 2009 Category: Drugs & Pharmacology Authors: M. Orhan Püsküllü, Sulhiye Y[inodot]ld[inodot]z, Hakan Göker Source Type: journals
New weapon against superbugsEmail this article to a colleague.
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SCOTTISH scientists have developed a chemical to tackle infections such as MRSA by mimicking the body's ability to fight bacteria. (Source: Scotsman.com News - Health)
Source: Scotsman.com News - Health - November 19, 2009 Category: Consumer Health News Source Type: news
"RAISIN" - a national programme for early warning, investigation and surveillance of healthcare-associated infection in FranceEmail this article to a colleague.
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We describe the development and current organisation of surveillance of HAI in France and summarise key achievements and results. Surveillance of HAI is under the auspice of the national institute for public health surveillance through a central coordinating structure, the Réseau d'alerte, d'investigation et de surveillance des infections nosocomiales (RAISIN), which consists of five regional coordinating structures, two national advisory committees of the Ministry of Health and public health agencies. Surveillance includes the performance of national prevalence surveys every five years (latest in 2006), specific surveill...
Source: Eurosurveillance latest news - November 19, 2009 Category: Infectious Diseases Source Type: journals
Recent Developments At Burnham Institute For Medical Research, November 2009Email this article to a colleague.
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New antibiotics for methicillin-resistant Staphylococcus aureus (MRSA) and other pesky bacteria. Andrei Osterman and collaborators have used comparisons of bacterial genomes to identify new targets for antibiotics and produced first-generation chemical inhibitors of a class of bacterial enzymes, called NadDs (nicotinate mononucleotide adenylyltransferases). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 18, 2009 Category: Consumer Health News Tags: MRSA / Drug Resistance Source Type: news
Recent Developments At Burnham Institute For Medical Research, November 2009Email this article to a colleague.
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New antibiotics for methicillin-resistant Staphylococcus aureus (MRSA) and other pesky bacteria. Andrei Osterman and collaborators have used comparisons of bacterial genomes to identify new targets for antibiotics and produced first-generation chemical inhibitors of a class of bacterial enzymes, called NadDs (nicotinate mononucleotide adenylyltransferases). Described in a recent article in Chemistry & Biology (Cell Press), the team, led by Dr. (Source: Cancer / Oncology News From Medical News Today)
Source: Cancer / Oncology News From Medical News Today - November 18, 2009 Category: Cancer & Oncology Tags: MRSA / Drug Resistance Source Type: news
Small drop in assaults against NHS staffEmail this article to a colleague.
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Figures show a 2.2% fall in attacks on NHS workersRelated items from OnMedicaHealth Bill promises direct payments for healthcarePatients to be asked even more about their GPGrowing role for GPs in MRSA detectionMPs warn polyclinics may be unnecessary and costlyEntire GP practice’s data stolen (Source: OnMedica Latest News)
Source: OnMedica Latest News - November 17, 2009 Category: UK Health Source Type: news
Unrecognized Invasive Infection in a Neonate Colonized with Methicillin-Resistant Staphylococcus aureusEmail this article to a colleague.
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A 3-month-old, 26-week premature infant presented to a regional hospital with macrocephaly. Head computed tomography revealed abnormal brain with limited cortical tissue, ventriculomegaly, and ring-enhancing foci, prompting referral to our center. Magnetic resonance imaging confirmed extensive cerebral abscesses (). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 16, 2009 Category: Pediatrics Authors: Rebecca S. Woodlief, Jonathan E. Markowitz Tags: Insights Source Type: journals
Why Certain Drug Combinations BackfireEmail this article to a colleague.
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Combination drug therapy has become a staple for treating many infections. For instance, doctors treat extensively drug resistant forms of tuberculosis with one drug that breaks down the pathogen's protective barriers and opens the door for another to deliver the deathblow. Just as some drugs work better together, however, other pairings are counter-productive. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 16, 2009 Category: Consumer Health News Tags: MRSA / Drug Resistance Source Type: news
Why Certain Drug Combinations BackfireEmail this article to a colleague.
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Combination drug therapy has become a staple for treating many infections. For instance, doctors treat extensively drug resistant forms of tuberculosis with one drug that breaks down the pathogen's protective barriers and opens the door for another to deliver the deathblow. Just as some drugs work better together, however, other pairings are counter-productive. (Source: MRSA / Drug Resistance News From Medical News Today)
Source: MRSA / Drug Resistance News From Medical News Today - November 16, 2009 Category: Drugs & Pharmacology Tags: MRSA / Drug Resistance Source Type: news
bioMérieux Launches a Molecular Diagnostic MRSA Test on its EasyQ® Automated PlatformEmail this article to a colleague.
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Methicillin-resistant Staphylococcus aureus (MRSA) is the most prevalent multi-drug resistant bacteria and a growing threat to health.
Marcy l'Etoile, France, 6 November 2009 - bioMérieux, a world leader in the field of in vitro diagnostics, today launched NucliSENS EasyQ® MRSA, a new automated test for methicillin-resistant Staphylococcus aureus (MRSA), one of the leading causes of healthcare-associated infections. NucliSENS EasyQ MRSA is CE marked and bioMérieux will be submitting for 510(k) approval with the US Food and Drug Administration in the first half of 2010.
"bi... (Source: Hospital Management)
Source: Hospital Management - November 16, 2009 Category: Hospital Management Source Type: info
In Vitro and In Vivo Efficacy of Teicoplanin-loaded Calcium Sulphate for the Treatment of Chronic MRSA Osteomyelitis.Email this article to a colleague.
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In vitro and in vivo therapeutic efficacy of teicoplanin-loaded calcium sulphate (TCS, 10 wt% teicoplanin) was investigated in a rabbit model of chronic methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis. The in vitro elution characteristics of teicoplanin from TCS pellets were realized by carrying out an evaluation on release kinetics, recovery rate and antibacterial activity of the released teicoplanin. Chronic osteomyelitis was induced by inoculating 10(7) cfu of MRSA strain into the tibial cavity of rabbits. After 3 weeks, the animals were treated by debridement, followed by implantation of TCS pellet...
Source: Antimicrobial Agents and Chemotherapy - November 16, 2009 Category: Microbiology Authors: Jia WT, Luo SH, Zhang CQ, Wang JQ Tags: Antimicrob Agents Chemother Source Type: journals
Interaction of ceftobiprole with the Enterococcus faecium low-affinity PBP5.Email this article to a colleague.
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Ceftobiprole is a new cephalosporin that exhibits a high affinity for the methicillin-resistant Staphylococcus aureus PBP2a. It was reported that ceftobiprole did not interact with a mutated form of the low-affinity Enterococcus faecium PBP5 (PBBP5fm) that when over-expressed confers a beta-lactam resistance phenotype to the bacterium. Our results show that ceftobiprole binds to the unmutated PBP5fm to form a stable acyl-enzyme and that it is able to efficiently kill a penicillin-resistant Enterococcus faecium strain that has this protein.
PMID: 19917749 [PubMed - as supplied by publisher] (Source: Antimicrobial Ag...
Source: Antimicrobial Agents and Chemotherapy - November 16, 2009 Category: Microbiology Authors: Henry X, Amoroso A, Coyette J, Joris B Tags: Antimicrob Agents Chemother Source Type: journals
Ceftobiprole is Superior to Vancomycin, Daptomycin, and Linezolid, for the Treatment of Methicillin-Resistant Staphylococcus aureus Experimental Endocarditis in Rabbits.Email this article to a colleague.
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Beta lactam agents are the most active drugs for the treatment of streptococci and methicillin-susceptible Staphylococcus aureus endocarditis. However, methicillin-resistant S. aureus (MRSA) are resistant to all beta lactam agents licensed to date, and alternative treatments are limited. Ceftobiprole is a novel broad-spectrum cephalosporin that binds with high affinity to PBP 2a, the penicillin-binding protein that mediates methicillin resistance of staphylococci, and is active against MRSA. Ceftobiprole was compared to vancomycin, daptomycin, and linezolid, in a rabbit model of MRSA aortic valve endocarditis caused by...
Source: Antimicrobial Agents and Chemotherapy - November 16, 2009 Category: Microbiology Authors: Tattevin P, Basuino L, Bauer D, Diep BA, Chambers HF Tags: Antimicrob Agents Chemother Source Type: journals
Predictors of oxygen desaturation during the six-minute walk test in patients with cystic fibrosisEmail this article to a colleague.
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CONCLUSIONS: Resting SpO2 < 96% and FEV1 < 40% can predict oxygen desaturation during the 6MWT. (Source: Jornal Brasileiro de Pneumologia)
Source: Jornal Brasileiro de Pneumologia - November 14, 2009 Category: Respiratory Medicine Source Type: journals
Association between nutritional status and dietary intake in patients with cystic fibrosisEmail this article to a colleague.
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CONCLUSIONS: The prevalence of malnutrition was low in this sample of patients. The study model demonstrated an association between dietary intake and nutritional status. Dietary intake was a predictive factor of statural growth in patients with cystic fibrosis. (Source: Jornal Brasileiro de Pneumologia)
Source: Jornal Brasileiro de Pneumologia - November 14, 2009 Category: Respiratory Medicine Source Type: journals
Dissemination of Methicillin‐Resistant Staphylococcus aureus USA300 Sequence Type 8 Lineage in Latin AmericaEmail this article to a colleague.
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Conclusion. A variant CA‐MRSA USA300 clone has become established in South America and, in some countries, is endemic in hospital settings. (Source: Clinical Infectious Diseases Latest Issue)
Source: Clinical Infectious Diseases Latest Issue - November 13, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
A rare case of sudden blindness due to a pituitary adenoma coincidentally infected with methicillin-resistant Staphylococcus aureus (MRSA)Email this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00701-009-0551-7Authors
Nicolaas A. Bakker, University Medical Center Groningen, University of Groningen Department of Neurosurgery P.O. Box 30.001 9700 RB Groningen The NetherlandsEelco W. Hoving, University Medical Center Groningen, University of Groningen Department of Neurosurgery P.O. Box 30.001 9700 RB Groningen The Netherlands
Journal Acta NeurochirurgicaOnline ISSN 0942-0940Print ISSN 0001-6268 (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - November 13, 2009 Category: Neurology Tags: Acta Neurochirurgica Source Type: journals
Fosfomycin: an old, new friend?Email this article to a colleague.
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Abstract Fosfomycin (FOM) is an antibiotic which has varying application indications across the globe. European, Japanese, South African
and Brazilian usage practices are much broader, involving multiple formulations of FOM than the currently limited application
of FOM in the United States, where uncomplicated urinary tract infection represents the only indication for FOM-tromethamine.
Based on early difficulty in determining FOMs genuine in vitro activity, there was initial skepticism about its efficacy and
application range. However, in the mid 1970s, correctly executed experiments coupled with an improved...
Source: European Journal of Clinical Microbiology & Infectious Diseases - November 13, 2009 Category: Microbiology Tags: European Journal of Clinical Microbiology & Infectious Diseases Source Type: journals
Should We Screen Low Risk Patients for Methicillin Resistant Staphylococcus Aureus?Email this article to a colleague.
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Since April 2009, all patients electively admitted to English hospitals must be screened for MRSA. Is universal screening effective? BMJ (Clinical research ed.) (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - November 13, 2009 Category: Orthopaedics Tags: Internal Medicine Source Type: info
Zyvox® Annual Appraisal of Potency and Spectrum program: linezolid surveillance program results for 2008Email this article to a colleague.
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In conclusion, the activity of linezolid remained uniform and stable across the sampled geographic regions studied when compared to the 2006 to 2007 results. Documented LZD-R remains rare (only 0.13% overall but highest for CoNS [0.41%] and enterococci [0.69%]) among the 24 countries sampled for the 6 different pathogen groups. Rates of clindamycin resistance and the frequency of MRSA varied by geographic region and between nations; therefore, like oxazolidinones, it requires continued surveillance for changing resistance patterns. (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - November 13, 2009 Category: Microbiology Authors: Ronald N. Jones, James E. Ross, Jan M. Bell, Uchino Utsuki, Ikeda Fumiaki, Intetsu Kobayashi, John D. Turnidge Tags: Antimicrobial Susceptibility Studies Source Type: journals
Should We Screen Low Risk Patients for Meticillin Resistant Staphylococcus Aureus?Email this article to a colleague.
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Since April 2009, all patients electively admitted to English hospitals must be screened for MRSA. Is universal screening effective? BMJ (Clinical research ed.) (Source: Medscape FamilyMedicine Headlines)
Source: Medscape FamilyMedicine Headlines - November 13, 2009 Category: Primary Care Tags: Internal Medicine Source Type: info
Molecular Epidemiology and Antimicrobial Resistance Mechanisms of Methicillin-Resistant Staphylococcus aureus Isolated from Bovine MilkEmail this article to a colleague.
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The aim of this study was to identify methicillin-resistant Staphylococcus aureus (MRSA) strains gathered from 2002 to 2006 from milk samples in Aydin region in Turkey. Among 93 S. aureus strains isolated from bovine milk with mastitis, 16 were resistant to methicillin. Methicillin-resistant S. aureus strains were studied further for their staphylococcal cassette chromosome mec (SCCmec) types, pulsotypes, spa and MLST types, antimicrobial susceptibilities, mechanisms of resistance and presence of Panton[ndash]Valentine leucocidin (PVL) toxin gene. The MRSA strains were multi-drug resistant. The susceptibility rates to anti...
Source: Zoonoses and Public Health - November 13, 2009 Category: Infectious Diseases Authors: S. Türkyılmaz, S. Tekbıyık, E. Oryasin, B. Bozdogan Source Type: journals
Contribution of Dermatologic Surgery in WarEmail this article to a colleague.
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This report outlines the important contribution of dermatologic surgery in the combat environment. The authors have indicated no significant interest with commercial supporters. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - November 13, 2009 Category: Dermatology Authors: MAJOR J. SCOTT HENNING, BAHAR F. FIROZ Source Type: journals
Characterisation of MRSA from Malta and the description of a Maltese epidemic MRSA strainEmail this article to a colleague.
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Abstract Malta has one of the highest prevalence rates of methicillin-resistant Staphylococcus aureus (MRSA) in Europe. However, only limited typing data are currently available. In order to address this situation, 45 MRSA
isolates from the Mater Dei Hospital in Msida, Malta, were characterised using DNA microarrays. The most common strain was
ST22-MRSA-IV (UK-EMRSA-15, 30 isolates). Sporadic strains included ST36-MRSA-II (UK-EMRSA-16, two isolates), PVL-positive
ST80-MRSA-IV (European Clone, one isolate), ST228-MRSA-I (Italian Clone/South German Epidemic Strain, one isolate) and ST239-MRSA-III
(Vienna/Hunga...
Source: European Journal of Clinical Microbiology & Infectious Diseases - November 12, 2009 Category: Microbiology Tags: European Journal of Clinical Microbiology & Infectious Diseases Source Type: journals
Clinical, molecular and epidemiological description of a cluster of community-associated methicillin-resistant Staphylococcus aureus isolates from injecting drug users with bacteraemiaEmail this article to a colleague.
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Clin Microbiol Infect Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is an increasing problem, predominantly in previously healthy individuals including notable risk groups such as the homeless, those who play close-contact sports, military personnel, men who have sex with men (MSM) and injecting drug users (IDUs). Over a 5-month period, four IDUs were admitted to Addenbrooke's Hospital, Cambridge, UK, with MRSA bacteraemia. All four patients presented with complex clinical features, with more than one focus of infection, and were linked epidemiologically. The atypical antibiogram of the MRSA is...
Source: Clinical Microbiology and Infection - November 12, 2009 Category: Microbiology Authors: F. J. Cooke, E. Gkrania-Klotsas, J. C. Howard, M. Stone, A. M. Kearns, M. Ganner, A. J. Carmichael, N. M. Brown Source Type: journals
Experience of European intensive care physicians with infections due to antibiotic-resistant bacteria, 2009Email this article to a colleague.
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A survey was performed among European intensive care physicians to obtain information about their perception and experience with selected antibiotic-resistant bacteria. Seventy-eight out of 95 (82%) participants considered having to deal with infections due to antibiotic-resistant bacteria in the intensive care unit where they work was a major or significant problem. Methicillin-resistant Staphylococcus aureus (MRSA) and third-generation cephalosporin-resistant Enterobacteriaceae were the most frequently reported antibiotic-resistant bacteria with 69 (73%) and 67 (71%) participants reporting having treated at least one pat...
Source: Eurosurveillance latest news - November 12, 2009 Category: Infectious Diseases Source Type: journals
Methicillin-Resistant Staphylococcus aureus (MRSA)-Active Metabolites from Platanus occidentalis (American Sycamore)Email this article to a colleague.
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Journal of Natural Products, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Natural Products)
Source: Journal of Natural Products - November 11, 2009 Category: Biochemistry Tags: article Source Type: journals
Cytarabine: MRSA pyomyositis: case reportEmail this article to a colleague.
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(Source: Reactions)
Source: Reactions - November 11, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals
Nurses Welcome News That Infection Rates Are DecreasingEmail this article to a colleague.
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This report rightly praises the hard work and dedication of healthcare staff who have made significant progress in tackling MRSA and C. difficile. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 11, 2009 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news
Nurses Welcome News That Infection Rates Are DecreasingEmail this article to a colleague.
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This report rightly praises the hard work and dedication of healthcare staff who have made significant progress in tackling MRSA and C. difficile. The leadership and innovation of nurses has been crucial in delivering reduced infection rates and improving the quality of care for all patients. (Source: MRSA / Drug Resistance News From Medical News Today)
Source: MRSA / Drug Resistance News From Medical News Today - November 11, 2009 Category: Drugs & Pharmacology Tags: Infectious Diseases / Bacteria / Viruses Source Type: news
Impact of a Change in Antibiotic Prophylaxis on Total Antibiotic Use in a Surgical Intensive Care UnitEmail this article to a colleague.
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Conclusion Change to single shot prophylaxis along with an ongoing antibiotic stewardship program resulted in a cut-back in total antibiotic
use amounting to as much as 15%. It would therefore appear that targeting interventions aimed at reducing antibiotic prophylaxis
in surgical ICUs may be very worthwhile.
Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-009-9115-2Authors
E. Meyer, Charité University Medicine Institute of Hygiene and Environmental Medicine Hindenburgdamm 27 12203 Berlin GermanyF. Schwab, Charité University Medicine Institute of Hygiene and...
Source: Infection - November 11, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals
A variant of the Southern German clone of methicillin-resistant Staphylococcus aureus is predominant in CroatiaEmail this article to a colleague.
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Clin Microbiol Infect The aim of the present study was to investigate the antibiotic susceptibility patterns and molecular epidemiology of clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates recovered in 24 hospitals in 20 cities in Croatia from October to December 2004. A total of 1815 consecutive S. aureus isolates were recovered, 248 of which were MRSA. The MRSA isolates were analysed using spa typing, multilocus sequence typing and SCCmec typing. Furthermore, the presence of Panton[ndash]Valentine leukocidin (PVL) genes was determined as a genetic marker for community-associated MRSA. The MRSA prevalen...
Source: Clinical Microbiology and Infection - November 11, 2009 Category: Microbiology Authors: A. Budimir, R. H. Deurenberg, Z. Bo[scaron]njak, E. E. Stobberingh, H. Cetkovic, S. Kalenic Source Type: journals
Polyisoprenylated Benzophenones from Clusiaceae: Potential Drugs and Lead Compounds.Email this article to a colleague.
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Many new polyisoprenylated benzophenones with a bicyclo[3.3.1]-nonane-2,4,9-trione core structure have been isolated from plants in the Clusiaceae family, and their potent biological properties have been the subject of several studies. This review summarizes the biological activities reported for these secondary metabolites including cytotoxic, antimicrobial, antioxidant, and anti-inflammatory activities. Our efforts during the past years have foremost been directed towards isolating new polyisoprenylated benzophenones, as well as understanding the possible target and mechanism of action through which these compounds a...
Source: Current Topics in Medicinal Chemistry - November 11, 2009 Category: Chemistry Authors: Acuña UM, Jancovski N, Kennelly EJ Tags: Curr Top Med Chem Source Type: journals
Effects of daptomycin in combination with other antimicrobial agents: a review of in vitro and animal model studiesEmail this article to a colleague.
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This review summarizes the in vitro and animal model data available on antibiotic combinations with daptomycin. The majority of studies focus on the clinically relevant combinations of daptomycin with rifampicin or with gentamicin. These studies demonstrate that daptomycin does not adversely affect the activity of other antimicrobial agents that may be administered concomitantly. Overall, additive or indifferent effects with daptomycin combinations were observed; however, synergy was observed for certain isolates of vancomycin-resistant enterococci when exposed to daptomycin and rifampicin. Unexpected synergy was demonstra...
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Steenbergen, J. N., Mohr, J. F., Thorne, G. M. Tags: Review Source Type: journals
Characterization of methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative Staphylococcus spp. isolated from US West Coast public marine beachesEmail this article to a colleague.
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Conclusions
This is the first report of MRSA and MRCoNS isolated from marine water and intertidal beach sand. The MLST types and antibiotic carriage of five MRSA isolates were similar to hospital MRSA isolates rather than US community-acquired MRSA isolates. Our results suggest that public marine beaches may be a reservoir for transmission of MRSA to beach visitors as well as an ecosystem for exchange of antibiotic resistance genes among staphylococci and related genera. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Soge, O. O., Meschke, J. S., No, D. B., Roberts, M. C. Tags: Original research Source Type: journals
Diversity of antimicrobial resistance pheno- and genotypes of methicillin-resistant Staphylococcus aureus ST398 from diseased swineEmail this article to a colleague.
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Conclusions
MRSA ST398 isolates varied slightly in their virulence properties and spa types but differed distinctly in their antimicrobial resistance pheno- and genotypes as well as their ApaI-PFGE patterns. These data underline the ability of ST398 to acquire genetic material that might increase antimicrobial resistance and virulence. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Kadlec, K., Ehricht, R., Monecke, S., Steinacker, U., Kaspar, H., Mankertz, J., Schwarz, S. Tags: Original research Source Type: journals
Antimicrobial efficacy of eucalyptus oil and 1,8-cineole alone and in combination with chlorhexidine digluconate against microorganisms grown in planktonic and biofilm culturesEmail this article to a colleague.
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Conclusions
In conclusion, CHG may be combined with either crude EO or its major component 1,8-cineole for enhanced, synergistic antimicrobial activity against a wide range of microorganisms in planktonic and biofilm modes of growth; however, the superior antimicrobial efficacy associated with crude EO alone, compared with 1,8-cineole, favours its combination with CHG. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Hendry, E. R., Worthington, T., Conway, B. R., Lambert, P. A. Tags: Original research Source Type: journals
In vitro activity of nemonoxacin (TG-873870), a novel non-fluorinated quinolone, against clinical isolates of Staphylococcus aureus, enterococci and Streptococcus pneumoniae with various resistance phenotypes in TaiwanEmail this article to a colleague.
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Conclusions
Our findings point to a potentially useful role for nemonoxacin in the treatment of infections caused by MSSA, ciprofloxacin-susceptible MRSA and S. pneumoniae with various resistance phenotypes. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Chen, Y.-H., Liu, C.-Y., Lu, J.-J., King, C.-H. R., Hsueh, P.-R. Tags: Original research Source Type: journals
In vitro effect of physiological concentrations of human albumin on the antibacterial activity of tigecyclineEmail this article to a colleague.
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Conclusions
Correcting the total concentration for the reported literature binding values is unreliable since tigecycline antibacterial activity was greater than that suggested by the free fraction of the drug. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Alou, L., Gimenez, M.-J., Cafini, F., Aguilar, L., Sevillano, D., Gonzalez, N., Torrico, M., Prieto, J., Garcia-Rey, C., Garcia-Escribano, N. Tags: Original research Source Type: journals
Epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) among residents of nursing homes in BelgiumEmail this article to a colleague.
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Conclusions
A high prevalence of MRSA carriage in NH residents was associated with hospital care, co-morbidities and less-developed coordination of institutional care. The predominant MRSA strains from NH residents and hospitalized patients of the same area were identical. Strengthening and coordination of MRSA surveillance and control activities are warranted within and between NHs and hospitals. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Denis, O., Jans, B., Deplano, A., Nonhoff, C., De Ryck, R., Suetens, C., Struelens, M. J. Tags: Original research Source Type: journals
Detection of methicillin-resistant Staphylococcus aureus ST398 in food samples of animal origin in SpainEmail this article to a colleague.
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(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Lozano, C., Lopez, M., Gomez-Sanz, E., Ruiz-Larrea, F., Torres, C., Zarazaga, M. Tags: Research letters Source Type: journals
Silver (And Copper) Antimicrobial Bullets To Kill BacteriaEmail this article to a colleague.
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Dana Filoti of the University of New Hampshire will present thin films of silver and copper she has developed that can kill bacteria and may one day help to cut down on hospital infections. The antimicrobial properties of silver and copper have been known for centuries -- last year, the U.S. Environmental Protection Agency officially registered copper alloys, allowing them to be marketed with the label "kills 99.9% of bacteria within two hours. (Source: MRSA / Drug Resistance News From Medical News Today)
Source: MRSA / Drug Resistance News From Medical News Today - November 10, 2009 Category: Drugs & Pharmacology Tags: Infectious Diseases / Bacteria / Viruses Source Type: news
MRSA 'not the only threat to NHS'Email this article to a colleague.
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The government has taken its "eye off the ball" on hospital infections other than MRSA and C. diff, a group of MPs says. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - November 10, 2009 Category: Consumer Health News Tags: Health Source Type: news
Hospital bug tracking failsEmail this article to a colleague.
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THE Government has no idea how many people are dying from hospital bugs other than MRSA and Clostridium difficile, despite evidence they are on the rise, an MPs' report s (Source: Scotsman.com News - Health)
Source: Scotsman.com News - Health - November 10, 2009 Category: Consumer Health News Source Type: news
Reducing Healthcare Associated Infection in Hospitals in England 2008-09: report of the House of Commons Public Accounts CommitteeEmail this article to a colleague.
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Source: House of Commons Public Accounts Committee
Area: News
Every year over 300,000 patients in England acquire a healthcare associated infection whilst in hospital. These infections cost the NHS more than £1 billion a year. The House of Commons Public Accounts Committee has published its third report on reducing healthcare associated infection in hospitals in England. In 2000, the predecessor Committee had concluded that the NHS did not have a grip on the extent and costs of hospital acquired infection and that without robust data it was difficult to see how it could target activity and resources to best effect. In 20...
Source: NeLM - News - November 10, 2009 Category: Drugs & Pharmacology Source Type: organizations
Anti-Infective Strategies of the Future: Is there Room for Species-Specific Antibacterial Agents?Email this article to a colleague.
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Broad-spectrum antibiotics, directed against conserved bacterial targets, are the mainstay of antibacterial therapy. Increasing resistance, however, demands new strategies. Over time a number of therapeutic concepts have evolved, starting out with the use of polyclonal antisera, which were rapidly replaced by the easier to use antibiotics. Other concepts, such as immunotherapy, radioimmunotherapy, anti-virulence agents, phage therapy and others are under evaluation and often limited in application. In the discovery process of new antibiotics in the pharmaceutical industry quite a number of new agents have emerged, whic...
Source: Current Pharmaceutical Design - November 10, 2009 Category: Drugs & Pharmacology Authors: Then RL, Sahl HG Tags: Curr Pharm Des Source Type: journals
