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This page shows you the latest news and research items in this category.

Safety and feasibility of targeted agent combinations in solid tumours
Nature Reviews Clinical Oncology 10, 154 (2013). doi:10.1038/nrclinonc.2012.245 Authors: Sook Ryun Park, Myrtle Davis, James H. Doroshow & Shivaani Kummar The plethora of novel molecular-targeted agents (MTAs) has provided an opportunity to selectively target pathways involved in carcinogenesis and tumour progression. Combination strategies of MTAs are being used to inhibit multiple aberrant pathways in the hope of optimizing antitumour efficacy and to prevent development of (Source: Nature Clinical Practice Oncology)
Source: Nature Clinical Practice Oncology - January 29, 2013 Category: Cancer & Oncology Authors: Sook Ryun ParkMyrtle DavisJames H. DoroshowShivaani Kummar Tags: Review Source Type: research

Bcl-2-Enhanced Efficacy of Microtubule-Targeting Chemotherapy through Bim Overexpression: Implications for Cancer Treatment.
Abstract Bcl-2 is commonly overexpressed in tumors, where it is often associated with unfavorable outcome. However, it has also been linked to a favorable sensitivity to microtubule-targeting agents (MTAs). We show that Bcl-2-overexpressing lung and breast cancer cells were more sensitive to both paclitaxel and vinorelbine. Bcl-2 over-expression also significantly potentiated in vivo efficacy of paclitaxel, in terms of tumor volume decrease and survival benefits, in models of nude mice bearing lung cancer xenografts. To further investigate this favorable effect of Bcl-2, a genomic approach was taken. It revealed th...
Source: Neoplasia - January 1, 2013 Category: Cancer & Oncology Authors: Savry A, Carre M, Berges R, Rovini A, Pobel I, Chacon C, Braguer D, Bourgarel-Rey V Tags: Neoplasia Source Type: research

Meta-analysis of the Relationship Between Dose and Benefit in Phase I Targeted Agent Trials
Conclusions Patients treated in the context of phase I trials with MTAs continue to derive reasonable clinical benefit. Contrary to other single institution data, our data suggest clinical benefit in terms of increasing response and overall survival with increasing dose. (Source: JNCI)
Source: JNCI - December 18, 2012 Category: Cancer & Oncology Authors: Gupta, S., Hunsberger, S., Boerner, S. A., Rubinstein, L., Royds, R., Ivy, P., LoRusso, P. Tags: Review Source Type: research

Dynamics of brain structure and cognitive function in the Alzheimer's disease neuroimaging initiative
Conclusions Despite average decline in brain structure, improvement was observed and related to cognition and MCI–AD conversion. Ageing-related brain changes reflect a dynamic process. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 13, 2012 Category: Neurosurgery Authors: Song, X., Mitnitski, A., Zhang, N., Chen, W., Rockwood, K., for the Alzheimer's Disease Neuroimaging Initiative Tags: Dementia, Drugs: CNS (not psychiatric), Memory disorders (psychiatry), Psychiatry of old age Cognition Source Type: research

MicroRNAs: Novel mediators of resistance to microtubule-targeting agents
Summary: MicroRNAs (miRNAs) are small, non-coding RNAs that act as expression regulators of genes involved in diverse cellular processes, including cell proliferation, differentiation, and apoptosis. Abnormal expression of miRNAs can have profound effects on cellular function, and miRNAs are implicated in tumourigenesis either as oncogenes or tumour suppressors. Deregulated miRNAs have been shown to have a role in the resistance of cancer cells to microtubule-targeting agents (MTAs). Here, we discuss how altered expression of miRNAs mediates resistance to clinically useful MTAs, such as paclitaxel and vincristine. Understa...
Source: Cancer Treatment Reviews - August 20, 2012 Category: Cancer & Oncology Authors: Arun Kanakkanthara, John H. Miller Tags: Laboratory-Clinic Interface Source Type: research

Defining the risk of toxicity in phase I oncology trials of novel molecularly targeted agents: a single centre experience
Conclusions Therapy with novel MTAs in phase I trials is associated with a moderate risk of significant toxicity. This appears less than in phase I studies involving cytotoxic agents, particularly in relation to grade 4 toxicity. The risk of death is low. (Source: Annals of Oncology)
Source: Annals of Oncology - July 24, 2012 Category: Cancer & Oncology Authors: Molife, L. R., Alam, S., Olmos, D., Puglisi, M., Shah, K., Fehrmann, R., Trani, L., Tjokrowidjaja, A., de Bono, J. S., Banerji, U., Kaye, S. B. Tags: clinical trials Source Type: research

Biocompatibility of an experimental MTA sealer implanted in the rat subcutaneous: Quantitative and immunohistochemical evaluation.
Abstract The tissue reaction promoted by an experimental mineral trioxide aggregate sealer (MTAS) in the rat subcutaneous was evaluated by morphological and morphometric analyses. In the animals from each group (n = 20), polyethylene tubes filled with MTAS, Portland cement (PC) or MTA were implanted in the dorsal subcutaneous. In the control group, empty tubes were implanted. After 7, 14, 30, and 60 days, the specimens were fixed and embedded in paraffin. In the HE-stained sections, the numerical density of inflammatory cells (IC) in the capsule was evaluated and statistical analyses performed (p ≤ 0.05). The exp...
Source: Biomed Res - July 23, 2012 Category: Research Authors: Viana Viola N, Maria Guerreiro-Tanomaru J, Ferreira da Silva G, Sasso-Cerri E, Tanomaru-Filho M, Cerri PS Tags: J Biomed Mater Res B Appl Biomater Source Type: research

Meta‐analysis of Phase III randomized trials of molecular targeted therapies for advanced pancreatic cancer
Conclusions: The findings of this study suggest that the palliation of PC with gemcitabine and MTAs does not provide a significant survival benefit and is associated with increased grade 3 and 4 toxicities. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - February 26, 2012 Category: Gastroenterology Authors: Karim M. EltawilPaul D. RenfrewMichele Molinari Source Type: research

Failure of Setting of Mineral Trioxide Aggregate in the Presence of Fetal Bovine Serum and Its Prevention
Conclusions: MTA did not set when the mixed MTA was exposed to FBS for 4 days. In these cases, 10% CaCl2 helped the setting of MTA, and the effect was more pronounced in ProRoot MTA than in MTA-Angelus. In contrast, short-term exposure to FBS had minimal or no detrimental effects on the setting behaviors of both MTAs. (Source: Journal of Endodontics)
Source: Journal of Endodontics - January 9, 2012 Category: Dentistry Authors: Yuran Kim, Sinyoung Kim, Yoo Seok Shin, Il-Young Jung, Seung Jong Lee Tags: Technology Source Type: research

The use of melting curves as a novel approach for validation of real-time PCR instruments.
In this study, high resolu- tion melting curve (HRM) analysis is presented as a novel validation method for real-time PCR instruments. By ap- plying HRM analysis using a defined PCR amplicon and EvaGreen dye, information about the temperature accuracy and thermal homogeneity of the heating block was obtained. This pilot study shows the potential of our technique for temperature validation of real-time quantitative PCR thermal cyclers. Our data correlated well with the tempera- ture accuracy data obtained from the Mobile Temperature Acquisition System (MTAS; r2 = 0.93), which conforms to the National Institute of Standards ...
Source: BioTechniques - September 1, 2011 Category: Biotechnology Authors: Keyserling HV, Bergmann T, Wiesel M, Kaufmann AM Tags: Biotechniques Source Type: research

Phase I Trials of Molecularly Targeted Agents: Should We Pay More Attention to Late Toxicities? [Phase I and Clinical Pharmacology]
Conclusion Moderate and severe toxicities occur regularly after the first cycle in phase I trials of MTAs and may deserve increased attention in the RP2D process for these agents. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - April 28, 2011 Category: Cancer & Oncology Authors: Postel-Vinay, Gomez-Roca, Molife, Anghan, Levy, Judson, De Bono, Soria, Kaye, Paoletti Tags: Phase I and Clinical Pharmacology Source Type: research

Multiple target loci assembly sequencing (mTAS).
Here we present multiple target loci assembly sequencing (mTAS), a method for examining multiple genomic loci in a single DNA sequencing read. The key to the success of mTAS target sequencing is the uniform amplification of multiple target genomic loci into a single DNA fragment using polymerase cycling assembly (PCA). Using this strategy, we successfully collected multiloci sequence information from a single DNA sequencing run. We applied mTAS to examine 29 different sets of human genomic loci, each containing from 2 to 11 single-nucleotide polymorphisms (SNP) present at different exons. We believe mTAS can be used to...
Source: Analytical Biochemistry - April 15, 2011 Category: Biochemistry Authors: Han H, Yoon JK, Cho BC, Kim H, Bang D Tags: Anal Biochem Source Type: research

Mechanism of MT-facilitated Nuclear Import [Cell Biology]
Although the microtubule (MT) cytoskeleton has been shown to facilitate nuclear import of specific cancer-regulatory proteins including p53, retinoblastoma protein, and parathyroid hormone-related protein (PTHrP), the MT association sequences (MTASs) responsible and the nature of the interplay between MT-dependent and conventional importin (IMP)-dependent nuclear translocation are unknown. Here we used site-directed mutagenesis, live cell imaging, and direct IMP and MT binding assays to map the MTAS of PTHrP for the first time, finding that it is within a short modular region (residues 82–108) that overlaps with the IMP�...
Source: Journal of Biological Chemistry - April 14, 2011 Category: Chemistry Authors: Roth, D. M., Moseley, G. W., Pouton, C. W., Jans, D. A. Tags: Signal Transduction Source Type: research

pH, Calcium Ion Release, and Setting Time of an Experimental Mineral Trioxide Aggregate–based Root Canal Sealer
Conclusions: MTAS presented favorable properties for its indication as a root canal sealer. (Source: Journal of Endodontics)
Source: Journal of Endodontics - April 13, 2011 Category: Dentistry Authors: Santiago Massi, Mário Tanomaru-Filho, Guilherme Ferreira Silva, Marco Antonio Hungaro Duarte, Larissa Tercilia Grizzo, Marília Afonso Rabelo Buzalaf, Juliane Maria Guerreiro-Tanomaru Tags: Technology Source Type: research

Heterogeneity in the definition of dose-limiting toxicity in phase I cancer clinical trials of molecularly targeted agents: A review of the literature
Conclusions: While our results do not support a standardisation of the definition of DLT, the inclusion of following specifications in its definition when relevant would reduce the heterogeneity observed across trials: (1) DLT assessment period, (2) absolute severity according to NCI CTCAE classification as well as severity relative to baseline status, (3) minimum duration of toxicity, (4) reversibility of toxicity within a certain period of time, and (5) necessity to delay treatment or to reduce dose-intensity. (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 10, 2011 Category: Cancer & Oncology Authors: Christophe Le Tourneau, Albiruni R.A. Razak, Hui K. Gan, Simona Pop, Véronique Diéras, Patricia Tresca, Xavier Paoletti Tags: Clinical oncology Source Type: research

Peripheral neuropathy with microtubule-targeting agents: occurrence and management approach.
Microtubule-targeting agents (MTAs), which include vinca alkaloids, taxanes, and the recently introduced epothilone, ixabepilone, are widely used chemotherapeutic agents for treatment of patients with cancer. MTAs interfere with the normal structure and function of microtubules, leading to cell-cycle arrest and tumor cell death. Microtubule function is critical to normal neuronal function, thus MTA therapy is commonly associated with some form of neuropathy. There is poor agreement between tools for clinical assessment of MTA-associated peripheral neuropathy, and standardization of grading scales is needed to reduce va...
Source: Clinical Genitourinary Cancer - March 31, 2011 Category: Cancer & Oncology Authors: Carlson K, Ocean AJ Tags: Clin Breast Cancer Source Type: research

Juniors needed support over MMC/MTAS
(Source: BMJ Online First)
Source: BMJ Online First - February 28, 2011 Category: Journals (General) Authors: Chan, S. Y. Tags: Medical humanities LETTERS Source Type: research

Mitosis is not a key target of microtubule agents in patient tumors
Tito Fojo Mitosis-specific agents have, to date, not been clinically successful. By contrast, microtubule-targeting agents (MTAs) have a long record of success, usually attributed to the induction of mitotic arrest. Indeed, it was this success that led to the search for mitosis-specific inhibitors. We believe the clinical (Source: Nature Clinical Practice Oncology)
Source: Nature Clinical Practice Oncology - January 31, 2011 Category: Cancer & Oncology Authors: Edina Komlodi-PasztorDan SackettJulia WilkersonTito Fojo Tags: Perspectives Source Type: research

Bacterial leakage in root canals filled with conventional and MTA‐based sealers
Conclusions All sealers evaluated allowed bacterial leakage. The MTA‐based sealers had the most leakage. (Source: International Endodontic Journal)
Source: International Endodontic Journal - January 27, 2011 Category: Dentistry Authors: A. C. M. OliveiraJ. M. G. TanomaruN. Faria‐JuniorM. Tanomaru‐Filho Source Type: research

Evaluation of the dimensional changes of mineral trioxide aggregate sealer
Conclusions The novel sealer based on MTA demonstrated adequate setting time and was dimensionally stable. It has the potential to be used as root canal sealer cement in clinical practice. (Source: International Endodontic Journal)
Source: International Endodontic Journal - January 23, 2011 Category: Dentistry Authors: J. CamilleriB. Mallia Source Type: research

A Response to Rome: Lessons from pre- and post-publication data-sharing in the C. elegans research community
Conclusions: The greater scientific community is likely to benefit from understanding the factors that motivate C. elegans researchers to share. In this sense, our research is a 'response' to calls for a greater amount of sharing in other research communities, such as the mouse community, specifically, the call for increased investment and support of centralized resource sharing infrastructure, grant-based funding of data-sharing, clarity of third party recommendations regarding sharing, third party insistence of post-publication data sharing, a decrease in patenting and restrictive MTAs and increased attribution and rewar...
Source: BMC Genomics - Latest articles - December 15, 2010 Category: Genetics & Stem Cells Authors: Matthew VoellLily FarrisEdwin LevyEmily Marden Source Type: research

Analysis of Arsenic in Gray and White Mineral Trioxide Aggregates by Using Atomic Absorption Spectrometry
Conclusions: The present in vitro studies demonstrated that there is no threat to patient health in using commercially available brands of MTA for endodontic practices. (Source: Journal of Endodontics)
Source: Journal of Endodontics - October 14, 2010 Category: Dentistry Authors: Tsunenori Matsunaga, Masaki Tsujimoto, Tadashi Kawashima, Yasuhisa Tsujimoto, Mamoru Fujiwara, Atsushi Ookubo, Yoshihiko Hayashi Tags: Technology Source Type: research

Dynamic sealing ability of MTA root canal sealer
Conclusions The novel sealer based on mineral trioxide aggregate had comparable sealing ability to a proprietary brand sealer cement. In contact with a simulated body fluid, the MTA sealer released calcium ions in solution that encouraged the deposition of calcium phosphate crystals. (Source: International Endodontic Journal)
Source: International Endodontic Journal - July 13, 2010 Category: Dentistry Authors: J. Camilleri, M. G. Gandolfi, F. Siboni, C. Prati Source Type: research

The effect of modernising medical careers on foundation doctor career orientation in the northern ireland foundation school.
CONCLUSIONS: Despite introducing MMC with a coordinated UK wide specialty application process (MTAS), a detrimental effect on their career orientation was not evident. Pragmatic career choices based on lifestyle may be the reason why female doctors expressed a preference for care of the elderly and paediatrics while their male colleagues favoured acute, more surgically biased specialties. PMID: 21116421 [PubMed - in process] (Source: The Ulster Medical Journal)
Source: The Ulster Medical Journal - April 30, 2010 Category: Journals (General) Authors: O'Donnnell M, Noad R, Boohan M, Carragher A Tags: Ulster Med J Source Type: research

Analyses of Heavy Metals in Mineral Trioxide Aggregate and Portland Cement
Conclusions: Both MTAs released more arsenic than the amount specified in ISO 9917-1 (2007). Portland cements and MTAs showed evidence of heavy metals in the acid-soluble form as well as leaching in deionized water and SBF. MTA contained levels of arsenic higher than the safe limit specified by the ISO 9917-1 (2007). (Source: Journal of Endodontics)
Source: Journal of Endodontics - March 21, 2010 Category: Dentistry Authors: Matthew Schembri, George Peplow, Josette Camilleri Tags: Technology Source Type: research

Effect of Mineral Trioxide Aggregates and Portland Cements on Inflammatory Cells
Conclusion: MTAs were more biocompatible; however, more studies are required. (Source: Journal of Endodontics)
Source: Journal of Endodontics - March 7, 2010 Category: Dentistry Authors: Shahriar Shahi, Saeed Rahimi, Hamid Reza Yavari, Hadi Mokhtari, Leila Roshangar, Mehran Mesgary Abasi, Sahar Sattari, Majid Abdolrahimi Tags: Technology Source Type: research

Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment.
In conclusion, results from this study highlight the potential of these novel series of PBOX compounds, alone or in sequential combination with flavopiridol, as an effective therapy against CML. PMID: 20206141 [PubMed - as supplied by publisher] (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - March 1, 2010 Category: Drugs & Pharmacology Authors: Bright SA, Campiani G, Deininger MW, Lawler M, Williams DC, Zisterer DM Tags: Biochem Pharmacol Source Type: research

Impact of ultrasonic power density on hot water elution of severely biodegraded heavy oil from weathered soils.
An ultrasound-enhanced elution system using water at a temperature of 70 degrees C was employed to remove severely biodegraded heavy oil (SBHO) from weathered soil. The effect of varying the ultrasonic power density from 0 to 100WL(-1) on the elution of SBHO and three characteristic biomarkers (C(26-34) 17alpha 25-norhopanes, C(26-28) triaromatic steroids (TAS), and C(27-29) methyl triaromatic steroids (MTAS) was analyzed using GC/MS, scanning electron microscopy (SEM), and X-ray diffraction (XRD). The amount of SBHO and biomarkers present in the treated soils and eluent had significant negative correlation with increa...
Source: Chemosphere - February 8, 2010 Category: Chemistry Authors: Ji G, Guo F Tags: Chemosphere Source Type: research

The Biomineralization Ability of Mineral Trioxide Aggregate and Portland Cement on Dentin Enhances the Push-out Strength
Conclusion: It was concluded that the biomineralization process positively influenced the push-out bond strength of the cements, particularly the MTA groups. (Source: Journal of Endodontics)
Source: Journal of Endodontics - December 6, 2009 Category: Dentistry Authors: Jessie F. Reyes-Carmona, Mara S. Felippe, Wilson T. Felippe Tags: Technology Source Type: research

Kinetics of apatite formation on a calcium-silicate cement for root-end filling during ageing in physiological-like phosphate solutions
This study evaluated surface morphology and chemical transformations of an experimental accelerated calcium-silicate cement as a function of soaking time in different phosphate-containing solutions. Cement discs were immersed in Dulbecco’s phosphate-buffered saline (DPBS) or Hank’s balanced salt solution (HBSS) for different times (1–180 days) and analysed by scanning electron microscopy connected with an energy dispersive X-ray analysis (SEM-EDX) and micro-Raman spectroscopy. SEM-EDX revealed Ca and P peaks after 14 days in DPBS. A thin Ca- and P-rich crystalline coating layer was detected after 60&nb...
Source: Clinical Oral Investigations - November 27, 2009 Category: Dentistry Tags: Clinical Oral Investigations Source Type: research

CYT997 Causes apoptosis in human multiple myeloma
Summary Multiple Myeloma (MM) is an incurable malignancy of mature plasma cells. Microtubule targeting agents (MTAs) are an established class of drug that include many conventional and some novel compounds. MTAs function by inhibiting the polymerisation or depolymerisation of microtubules (MTs) within the cell, disrupting various important cellular functions. We have investigated pre-clinically the novel tubulin polymerisation inhibitor CYT997 for the potential treatment of MM. Here we demonstrate the promising anti-myeloma activity of CYT997 as evidenced by tubulin disruption, inhibition of growth and proli...
Source: Investigational New Drugs - November 11, 2009 Category: Drugs & Pharmacology Tags: Investigational New Drugs Source Type: research

A bad time to get sick?
This study was carried out by Dr Min Jen and colleagues from the Dr Foster Unit and other academic departments at Imperial College in London. The Dr Foster Unit is funded by a grant from Dr Foster Intelligence, an independent health service research organisation, and has indirect support from the National Institute of Health Research. The study was published in the peer-reviewed medical journal PLoS ONE. What kind of scientific study was this? The aim of this retrospective cohort study was to compare survival between a group of patients admitted as an emergency on the last Wednesday in July and the first Wednesday in Au...
Source: NHS News Feed - September 23, 2009 Category: Consumer Health News Tags: Medical practice Source Type: news

Reply to Conflating MTAs and patents
Nature Biotechnology 27, 505 (2009). doi:10.1038/nbt0609-505 (Source: Nature Biotechnology)
Source: Nature Biotechnology - June 10, 2009 Category: Biotechnology Tags: Opinion and Comment Source Type: research

Conflating MTAs and patents
Nature Biotechnology 27, 504 (2009). doi:10.1038/nbt0609-504b Author: Kevin E Noonan (Source: Nature Biotechnology)
Source: Nature Biotechnology - June 10, 2009 Category: Biotechnology Authors: Kevin E Noonan Tags: Opinion and Comment Source Type: research

Simulators improve skills of trainee surgeons
Skills enhanced by 50% and operating times halved by simulator useRelated items from OnMedicaNew training programme threatens patient care, say doctorsCMO's regret over medical training too little too lateDiabetes medics have less time for patients1 August, all changeMPs to look into training reforms and MTAS (Source: OnMedica Latest News)
Source: OnMedica Latest News - May 15, 2009 Category: UK Health Source Type: news

Psychological Impact of Systemic Training Failure On Mental Health and Career Satisfaction of UK Trainees: Lessons From an Online Attitudes Survey.
CONCLUSION: At the onset of MMC, MTAS applicants reported negative process experiences, psychological distress and poor coping (including increased alcohol use), with possible implications for mental health, career planning and patient care. PMID: 19240207 [PubMed - in process] (Source: The International Journal of Social Psychiatry)
Source: The International Journal of Social Psychiatry - February 27, 2009 Category: Psychiatry Authors: Lydall GJ, Malik A, Blizard R, Bhugra D Tags: Int J Soc Psychiatry Source Type: research

Psychological Impact of Systemic Training Failure On Mental Health and Career Satisfaction of UK Trainees: Lessons From an Online Attitudes Survey
Conclusion: At the onset of MMC, MTAS applicants reported negative process experiences, psychological distress and poor coping (including increased alcohol use), with possible implications for mental health, career planning and patient care. (Source: International Journal of Social Psychiatry)
Source: International Journal of Social Psychiatry - February 24, 2009 Category: Psychiatry Authors: Lydall, G. J., Malik, A., Blizard, R., Bhugra, D. Tags: Article Source Type: research

Management of Obstructive Sleep Apnea with a Mandibular and Tongue Advancement Splint (MTAS) in a Completely Edentulous Patient. A Clinical Report
Treatment of obstructive sleep apnea (OSA) in dentate patients using a mandibular advancement splint (MAS) from mandibular repositioners has been documented in detail. Nevertheless, studies about completely edentulous patients with OSA are sparse. This clinical report describes a clinical and laboratory method for producing a functional splint combining an MAS and a tongue-retaining device with an individualized tongue tip housing and discusses the rationale for using such a device. (Source: Journal of Prosthodontics)
Source: Journal of Prosthodontics - February 6, 2009 Category: Dentistry Authors: Huseyin Kurtulmus, H. Serdar Cotert Source Type: research

Comparison of Mineral Trioxide Aggregate's Composition with Portland Cements and a New Endodontic Cement.
The aim of this study was to compare the compositions of mineral trioxide aggregates (MTAs), Portland cements (PCs), and a new endodontic cement (NEC). Our study also investigated the surface characteristics of MTA and NEC root-end fillings when immersed in normal saline. For part I, we prepared samples of 9 brands of MTAs, PCs, and NEC. The materials were imaged and analyzed by scanning electron microscopy (SEM) and energy dispersive x-ray analysis (EDXA). In part II, 3-mm-deep root-end preparations were filled with MTA or NEC and stored in normal saline for 1 week. Samples were imaged and analyzed by SEM and electron...
Source: Journal of Endodontics - January 27, 2009 Category: Dentistry Authors: Asgary S, Eghbal MJ, Parirokh M, Ghoddusi J, Kheirieh S, Brink F Tags: J Endod Source Type: research

Computer glitch swaps junior doctors' exam results
Computer systems running the junior doctors' training application system have broken down swapped candidates qualifications and allowed them to see each other's answers. (Source: Telegraph Health)
Source: Telegraph Health - January 16, 2009 Category: Consumer Health News Tags: computer MTAS MMC junior doctors British Medical Association Royal College Paediatrics Obstetrics Psychiatry Source Type: news

GMC rejects calls for inquiry into MTAS
The General Medical Council has rejected calls for it to investigate the IT and selection procedures for Modernising Medical Careers. (Source: E-Health-Insider)
Source: E-Health-Insider - January 6, 2009 Category: Information Technology Source Type: news

PPARγ Inhibitors as Novel Tubulin-Targeting Agents
The microtubule-targeting agents (MTAs) are a very successful class of cancer drugs with therapeutic benefits in both hematopoietic and solid tumors. However, resistance to these drugs is a significant problem. Current MTAs bind to microtubules, and/or to their constituent tubulin heterodimers, and affect microtubule polymerization and dynamics. The PPARγ inhibitor T0070907 can reduce tubulin levels in colorectal cancer cell lines and suppress tumor growth in a murine xenograft model. T0070907 does not alter microtubule polymerization in vitro, and does not appear to work by triggering modulation of tubulin RNA leve...
Source: PPAR Research - June 3, 2008 Category: Biology Source Type: research

Antibodies Incorporated
is a long standing manufacturer of antibodies, antibody based diagnostic kits and reagents under its own label and as a contract manufacturer. Through its long history in the industry it has established not only a sterling reputation as a high quality, rapid response producer of antibodies, but as a versatile, teamwork oriented service provider. We adhere to the strict quality guidelines of ISO 13485 as certified by BSI. NEUROMABS MONOCLONAL ANTIBODIES We are currently the exclusive distributor of NeuroMabs. These are a series of high quality, fully characterized monoclonal antibodies that can be used for research purpo...
Source: Drug Development Technology - June 1, 2008 Category: Pharmaceuticals Source Type: news

Stress, lies and red tape: the views, success rates and stress levels of the MTAS cohort.
Conclusions MTAS was a flawed system. A considerable proportion (36%) of candidates who had been on a Senior House Officer training scheme were left without a training post after MTAS. The system seems to favour UK/EEA applicants. Applicants suffered significant psychological distress during and after the MTAS process. PMID: 18515779 [PubMed - in process] (Source: J R Soc Med AND (has...)
Source: J R Soc Med AND (has... - June 1, 2008 Category: Journals (General) Authors: Whelan P, Meerten M, Rao R, Jarrett P, Muthukumaraswamy A, Bhugra D Tags: J R Soc Med Source Type: research

Involvement of Sensory Input from Anterior Teeth in Deglutitive Tongue Function
Abstract Swallowing is a reflex that receives sensory information from the peripheral nerves and from the cerebral cortex. The aim of the present study was to investigate whether the sensory input from anterior teeth affects the functional characteristics of tongue pressure applied against the hard palate during swallowing. Subjects were eight healthy volunteers. Tongue pressure against the hard palate during swallowing 10 ml of water was measured under two conditions: preanesthesia and postanesthesia of anterior teeth. The sensory deprivation of anterior teeth was performed by periodontal anesthesia. Tongue...
Source: Dysphagia - May 31, 2008 Category: Speech Therapy Tags: Dysphagia Source Type: research

Stress, lies and red tape: the views, success rates and stress levels of the MTAS cohort
Conclusions MTAS was a flawed system. A considerable proportion (36%) of candidates who had been on a Senior House Officer training scheme were left without a training post after MTAS. The system seems to favour UK/EEA applicants. Applicants suffered significant psychological distress during and after the MTAS process. (Source: JRSM)
Source: JRSM - May 30, 2008 Category: UK Health Authors: Whelan, P., Meerten, M., Rao, R., Jarrett, P., Muthukumaraswamy, A., Bhugra, D. Tags: Research Source Type: research

[Clinical Trials] Nomograms to Predict Serious Adverse Events in Phase II Clinical Trials of Molecularly Targeted Agents
Conclusion A regression model was constructed that predicts the SAE and SAEatt risk for an individual patient during cycle 1 of phase II trial treatment with moderate to good internal validity. External validation is still required. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - March 6, 2008 Category: Cancer & Oncology Authors: Pond, Siu, Moore, Oza, Hirte, Winquist, Goss, Hudes, Townsley Tags: Clinical Trials Source Type: research

[Correspondence] MTAS fiasco: further shortlisting issues
(Source: Psychiatric Bulletin)
Source: Psychiatric Bulletin - February 29, 2008 Category: Psychiatry Authors: Lydall, G. J. Tags: Correspondence Source Type: research

Full Tooke report now available
The full report of the Independent Inquiry into Modernising Medical Careers (MMC) in the wake of the debacle surrounding MTAS, is now available to download as a PDF from the MMC website. (Source: MEDEV News)
Source: MEDEV News - January 13, 2008 Category: Universities & Medical Training Source Type: news

National IT system needed for medical recruitment
In his final report into the Modernising Medical Careers scheme, Sir John Tooke has labelled the online Medical Training Application Service (MTAS) as a 'crisis, which has revealed profound concerns about the new system of medical postgraduate training.' (Source: E-Health-Insider)
Source: E-Health-Insider - January 10, 2008 Category: Information Technology Source Type: news