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[Developments in cancer management by innovative genomics. 2008 report of the National Cancer Consortium.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the 3rd year of the program 8 new molecular diagnostic services have been introduced to clinic in the management of breast-, lung-, colorectal cancers as well as in GIST and melanoma. Two patents have been filed for innovative modulation of mito/motogenic signaling pathways in cancer cells. In preclinical models of human cancer a functional imaging technique was developed to detect vascular eff ects of erythropoietin. Using a genomic approach, the sequential changes in human melanoma during systemic dissemination were determined revealing several novel potential prognostic factors and some interesting novel targets ...
Source: Magyar Onkologia - December 1, 2009 Category: Cancer & Oncology Authors: Tímár J, Kásler M, Heringh A, Soós M, Mathiász D, Romány A, Józsa A, Szilák L, Forrai T, Patthy L, Kovács G Tags: Magy Onkol Source Type: journals

[Immunohistochemical phenotype of breast carcinomas predicts the eff ectiveness of primary systemic therapy.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Székely B, Dank M The purpose of the study was to identify breast cancer subtypes by immunohistochemistry likely to respond to neoadjuvant chemotherapy and to analyze the used chemotherapy regimen and the range of response rates. Analysis of a collected database was performed. Ninety-two patients were identified in our files who received neoadjuvant chemotherapy between 1998 and 2009. We used immunohistochemical profiles (ER, PgR, HER2, Ki-67 and p53) of NCB, FNAB and surgical breast specimens to subclassify the tumors. Pathological response rates were assessed following surgical removal of tumors by using the Ch...
Source: Magyar Onkologia - December 1, 2009 Category: Cancer & Oncology Authors: Kulka J, Tokés AM, Tóth AI, Szász AM, Farkas A, Borka K, Járay B, Székely E, Istók R, Lotz G, Madaras L, Korompay A, Harsányi L, László Z, Rusz Z, Molnár BA, Molnár IA, Kenessey I, Szentmártoni G Tags: Magy Onkol Source Type: journals

[Neoadjuvant radiochemotherapy in the treatment of locally advanced rectal tumors.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We investigated the response rate and side effects of simultaneous, neoadjuvant radiochemotherapy (RCT) in locally advanced rectal cancer. Between 2005 and 2007, we treated 112 patients in stage II-III rectal carcinoma at the Institute of Oncotherapy, University of Pécs. For staging abdomino-pelvic CT (112) and transrectal US (49) or pelvic MR (10), or PET-CT (1) was performed. Radiation therapy was delivered with 3D CRT-based technique using belly-board with 18 MV photon energy, while patients in prone position. A total dose of 45 Gy (single dose 1.8 Gy) was delivered to the tumor and the pelvic lymph nodes. 5-FU...
Source: Magyar Onkologia - December 1, 2009 Category: Cancer & Oncology Authors: Rápolti E, Szigeti A, Farkas R, Bellyei S, Boronkai A, Papp A, Gömöri E, Horváth OP, Mangel L Tags: Magy Onkol Source Type: journals

[Gene expression based multigene prognostic and predictive tests in breast cancer.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a summary of currently available RT-PCR and microarray based multigene tests including MammaPrint, Oncotype DX, BLN Assay, Theros Breast Cancer Index SM, MapQuant DX, ARUP Breast Bioclassifier, Celera Metastatic Score, eXagen BCtm, Invasive Gene Signature, Wound Response Indicator and Mammostrat. Two of these (Oncotype DX and MammaPrint) are already incorporated in several diagnostic protocols. However, multiple unsolved issues deteriorate the value of these tests: generally the validation is poor, the gene sets do not confirm each other, the associated costs are high and the necessary bioinformatics is highly c...
Source: Magyar Onkologia - December 1, 2009 Category: Cancer & Oncology Authors: Pénzváltó Z, Mihály Z, Gyorffy B Tags: Magy Onkol Source Type: journals

[Validation study of KRAS mutation in colorectal cancer.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There is no doubt that molecular targeted therapy has increasing importance in clinical oncology. Markers related to the molecular targets can help in the prediction of the antitumoral effect as well as in the positive or negative selection of patients. Such a marker is KRAS, since its mutation inhibits the effectiveness of anti-EGFR monoclonal antibodies in the treatment of advanced and/or metastatic colorectal cancer. To identify KRAS mutations different methods and techniques are available. A voluntarily performed study served to control the validity of our methods. As a result the 7 partcipating laboratories approa...
Source: Magyar Onkologia - December 1, 2009 Category: Cancer & Oncology Authors: Kopper L, Tímár J Tags: Magy Onkol Source Type: journals

[Lapatinib - treatment-option in trastuzumab-resistant breast cancer.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HER2 is overexpressed in 20-25% of breast cancers and is associated with an aggressive phenotype and poor prognosis. Lapatinib is a dual tyrosine kinase inhibitor selective for inhibition of epidermal growth factor receptor (EGFR1/ErbB1) and HER2/ErbB2. Having more targets, probably its antitumor activity could be more efficient. Preclinical data reveal that lapatinib has activity in trastuzumab-resistant cell lines as well as synergistic activity with trastuzumab. Phase I clinical trials have also shown that lapatinib is well tolerated, with mild diarrhea and skin rush as common toxic effects and low incidence of card...
Source: Magyar Onkologia - December 1, 2009 Category: Cancer & Oncology Authors: Pikó B Tags: Magy Onkol Source Type: journals

[Studies on claudins and prognostic factors in gastrointestinal diseases.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gastrointestinal tumors are highly ranked regarding tumoral mortality worldwide. The development and progression of gastrointestinal (GI) diseases go hand in hand with the changes of tight junctions (TJ). Claudins (CLDN) are the main TJ proteins, showing different expression by the different tissues, with the expressed CLDN profile being representative. I. We explored the changes of CLDN expression in Barrett's esophagus and related adenocarcinoma. CLDN2 and -3 expression in Barrett's esophagus was higher than in normal foveolar epithelium. Adenocarcinoma showed higher CLDN2 and -3 expression compared with normal and B...
Source: Magyar Onkologia - December 1, 2009 Category: Cancer & Oncology Authors: Gyorffy H Tags: Magy Onkol Source Type: journals

[The diagnostic value of microsatellite LOH analysis and the prognostic relevance of angiogenic gene expression in urinary bladder cancer.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bladder cancer is the second most common malignancy affecting the urinary system. Currently, histology is the only tool that determines therapy and patients' prognosis. As the treatment of non-invasive (Ta/T1) and muscle invasive (T2-T4) bladder tumors are completely different, correct staging is important, although it is often hampered by disturbing factors. Molecular methods offer new prospects for early disease detection, confirmation of unclear histological findings and prognostication. Applying molecular biological methods, the present study is searching for answers to current diagnostic and prognostic problems in...
Source: Magyar Onkologia - December 1, 2009 Category: Cancer & Oncology Authors: Szarvas T Tags: Magy Onkol Source Type: journals

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Authors: PMID: 20071312 [PubMed - in process] (Source: Magyar Onkologia)
Source: Magyar Onkologia - December 1, 2009 Category: Cancer & Oncology Tags: Magy Onkol Source Type: journals

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Authors: PMID: 20071313 [PubMed - in process] (Source: Magyar Onkologia)
Source: Magyar Onkologia - December 1, 2009 Category: Cancer & Oncology Tags: Magy Onkol Source Type: journals

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Authors: PMID: 20071314 [PubMed - in process] (Source: Magyar Onkologia)
Source: Magyar Onkologia - December 1, 2009 Category: Cancer & Oncology Tags: Magy Onkol Source Type: journals

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Authors: PMID: 20071315 [PubMed - in process] (Source: Magyar Onkologia)
Source: Magyar Onkologia - December 1, 2009 Category: Cancer & Oncology Tags: Magy Onkol Source Type: journals

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Authors: PMID: 20071316 [PubMed - in process] (Source: Magyar Onkologia)
Source: Magyar Onkologia - December 1, 2009 Category: Cancer & Oncology Tags: Magy Onkol Source Type: journals

[The development of the first line treatment of metastatic colorectal cancer (mCRC)]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chemotherapy options of metastatic colorectal cancer (mCRC) have been progressed rapidly in the last years. Besides of the standard fluorouracil/folinic acid treatment some new active agents (oxaliplatin and irinotecan) have been introduced, and more recently the "targeted" biologicals (bevacizumab, cetuximab, panitumumab) have demonstrated their high effectiveness. This review summarizes the development of the first line treatment of mCRC. PMID: 19793687 [PubMed - indexed for MEDLINE] (Source: Magyar Onkologia)
Source: Magyar Onkologia - September 1, 2009 Category: Cancer & Oncology Authors: László L, Tamás N Tags: Magy Onkol Source Type: journals

[Quality control of computed tomography scanners from the viewpoint of radiotherapy planning in Hungary]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this publication is to review the requirements necessary for using computed tomography (CT) for radiotherapy treatment planning. The equipments were tested with different CT phantoms. The authors made several measurements for checking the CT number, the quality and the mechanical parameters of CT tables. The CT numbers measured on the equipments of different manufacturers were in quite good agreement with the IAEA requirements. The geometric distortions of CT images are negligible, while the mechanical parameters of CT tables show considerable variety. A quality assurance - quality control protocol is recomm...
Source: Magyar Onkologia - September 1, 2009 Category: Cancer & Oncology Authors: Csilla P, Csaba W, Réka K, Balázs K, Stipan Z, István P, Pál Z Tags: Magy Onkol Source Type: journals

[Expression pattern of invasion-related molecules in brain tumors of different origin]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the mRNA expression of 29 invasion-related molecules (18 cell membrane receptors or receptor subunits (EGFRs and integrins) and 11 ECM components: collagens, laminins and fibronectin) was investigated by quantitative reverse transcriptase-polymerase chain reaction. Fresh frozen human tissue samples from glioblastoma (GBM) and intracerebral bronchial adenocarcinoma metastases (five pieces from each) were evaluated. Significant differences were established in six of the 29 molecules (ErbB1, 2, 3, integrins alpha3, 7 and beta1). To confirm our results at the protein level, immunohistochemical analysis of nine m...
Source: Magyar Onkologia - September 1, 2009 Category: Cancer & Oncology Authors: Miklós P, Gábor H, Imre V, György V, János S, László B, Péter R, Annamária K, Judit T, Zoltán H, Beáta S, Almos K Tags: Magy Onkol Source Type: journals

[Role of fibula in replacement of mandible]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The mandible and the fibula are two totally different bones of the human skeleton. The fibula is a long straight bone of the lower leg playing secondary role compared with the tibia. The mandible, or jaw bone, is the only facial bone that moves and has complex spatial structure. The blood supply of the mandible is mainly endosteal, the inferior mandibular artery, which is one of the more important branch of the maxillary artery is responsible for its arterial supply. The fibula shows the uniform pattern of periosteal blood supply receiving many small branches from the peroneal artery, and having only weak endosteal sup...
Source: Magyar Onkologia - September 1, 2009 Category: Cancer & Oncology Authors: Miklós F, Klara B, Miklós K Tags: Magy Onkol Source Type: journals

[Metachronous metastasis from rectal adenocarcinoma to the penis--case report]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite of its rich vascularization and extensive circulatory communication with neighboring organs, penile metastases are rare. Even more infrequent is a penile metastasis of rectum tumors. Since the first report of rectal carcinoma with metastasis to the penis (Ehbert 1870), approximately 50 cases have been reported, most of them from the USA, the remaining from Western Europe, the Middle East and Japan. The first Hungarian case is reported now of penile metastasis of a rectal carcinoma. The case of a 65-year-old man is presented: isolated penile metastasis discovered 4.5 years after the primary rectal cancer resecti...
Source: Magyar Onkologia - September 1, 2009 Category: Cancer & Oncology Authors: Zsófia K, István B, József L, Vanda P, Sándor M, Zsuzsanna P Tags: Magy Onkol Source Type: journals

[Antitumor activity of zoledronic acid]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bisphosphonates are used for supportive treatment in bone metastases of malignant diseases. Advance in various therapeutic options, molecular targeted therapies of malignant diseases result in longer survival, and may bring a higher number of patients surviving until development of secondary lesions, e.g. bone metastases. This review summarizes the antitumor activity of the amino-bisphosphonate zoledronate, describing results of in vitro and animal model studies. Zoledronic acid treatment in patients with malignant solid tumors causing bone metastases prolongs their survival. According to the emerging, until now not to...
Source: Magyar Onkologia - September 1, 2009 Category: Cancer & Oncology Authors: Lilla T Tags: Magy Onkol Source Type: journals

[Claudin expression in different pancreatic cancers and its significance in differential diagnostics]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Claudins (CLDNs) are essential proteins of tight junctions. Changes in their expression pattern have been demonstrated in a number of tumors. CLDNs-3 and -4 are receptors of the Clostridium perfringens enterotoxin, cytolytic effects of the toxin are well known. The aim of our studies was to compare the different CLDN expression patterns in normal pancreas cells, pancreatic endocrine tumors, adenocarcinomas, mucinous cystic tumors and acinar cell carcinomas. Expressions of CLDN-1, -2, -3, -4 and -7 proteins were examined using immunohistochemical as well as RT-PCR techniques and the following observations were made: 1.)...
Source: Magyar Onkologia - September 1, 2009 Category: Cancer & Oncology Authors: Katalin B Tags: Magy Onkol Source Type: journals

[Detection of ototoxic effect of cisplatin with otoacoustic emission in testicular cancer patients]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of the research was to detect the acute and long-term ototoxic effect of cisplatin in testicular cancer patients, using OAE (otoacoustic emission), a highly sensitive new objective method, for detecting medication-related hearing loss. Secondary objective was to evaluate the risk factors that contribute to hearing loss. In the study for acute hearing loss ten males with different histological types of testicular germ cell tumor were examined with TOAE (transiently evoked otoacoustic emission), before the 1st and after the 5th day of their 1st cycle of cytostatic therapy. Patients received 100 mg/m 2 cisplatin p...
Source: Magyar Onkologia - September 1, 2009 Category: Cancer & Oncology Authors: Krisztina B Tags: Magy Onkol Source Type: journals

[Abstracts from the 16th Conference on Primary Prevention, Budapest, May 20, 2009]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19793698 [PubMed - indexed for MEDLINE] (Source: Magyar Onkologia)
Source: Magyar Onkologia - September 1, 2009 Category: Cancer & Oncology Tags: Magy Onkol Source Type: journals

[The development of the first line treatment of metastatic colorectal cancer (mCRC).]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chemotherapy options of metastatic colorectal cancer (mCRC) have been progressed rapidly in the last years. Besides of the standard fluorouracil/folinic acid treatment some new active agents (oxaliplatin and irinotecan) have been introduced, and more recently the "targeted" biologicals (bevacizumab, cetuximab, panitumumab) have demonstrated their high effectiveness. This review summarizes the development of the first line treatment of mCRC. PMID: 19793687 [PubMed - in process] (Source: Magyar Onkologia)
Source: Magyar Onkologia - August 31, 2009 Category: Cancer & Oncology Authors: Landherr L, Nagykálnai T Tags: Magy Onkol Source Type: journals

[Quality control of computed tomography scanners from the aspect of radiotherapy treatment planning (Hungarian review).]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this publication is to review the requirements necessary for using computed tomography (CT) for radiotherapy treatment planning. The equipments were tested with different CT phantoms. The authors made several measurements for checking the CT number, the quality and the mechanical parameters of CT tables. The CT numbers measured on the equipments of different manufacturers were in quite good agreement with the IAEA requirements. The geometric distortions of CT images are negligible, while the mechanical parameters of CT tables show considerable variety. A quality assurance - quality control protocol is recomm...
Source: Magyar Onkologia - August 31, 2009 Category: Cancer & Oncology Authors: Pesznyák C, Weisz C, Király R, Kiss B, Zelić S, Polgár I, Zaránd P Tags: Magy Onkol Source Type: journals

[Expression pattern of invasion-related molecules in cerebral tumors of different origin.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the mRNA expression of 29 invasion-related molecules (18 cell membrane receptors or receptor subunits (EGFRs and integrins) and 11 ECM components: collagens, laminins and fibronectin) was investigated by quantitative reverse transcriptase-polymerase chain reaction. Fresh frozen human tissue samples from glioblastoma (GBM) and intracerebral bronchial adenocarcinoma metastases (five pieces from each) were evaluated. Significant differences were established in six of the 29 molecules (ErbB1, 2, 3, integrins alpha3, 7 and beta1). To confirm our results at the protein level, immunohistochemical analysis of nine m...
Source: Magyar Onkologia - August 31, 2009 Category: Cancer & Oncology Authors: Petrás M, Hutóczki G, Varga I, Vereb G, Szöllosi J, Bognár L, Ruszthi P, Kenyeres A, Tóth J, Hanzély Z, Scholtz B, Klekner A Tags: Magy Onkol Source Type: journals

[Role of fibula in replacement of mandible.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The mandible and the fibula are two totally different bones of the human skeleton. The fibula is a long straight bone of the lower leg playing secondary role compared with the tibia. The mandible, or jaw bone, is the only facial bone that moves and has complex spatial structure. The blood supply of the mandible is mainly endosteal, the inferior mandibular artery, which is one of the more important branch of the maxillary artery is responsible for its arterial supply. The fibula shows the uniform pattern of periosteal blood supply receiving many small branches from the peroneal artery, and having only weak endosteal sup...
Source: Magyar Onkologia - August 31, 2009 Category: Cancer & Oncology Authors: Fülöp M, Branzaniuc K, Kásler M Tags: Magy Onkol Source Type: journals

[Metachronous metastasis to the penis from carcinoma of the rectum - Case report.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite of its rich vascularization and extensive circulatory communication with neighboring organs, penile metastases are rare. Even more infrequent is a penile metastasis of rectum tumors. Since the first report of rectal carcinoma with metastasis to the penis (Ehbert 1870), approximately 50 cases have been reported, most of them from the USA, the remaining from Western Europe, the Middle East and Japan. The first Hungarian case is reported now of penile metastasis of a rectal carcinoma. The case of a 65-year-old man is presented: isolated penile metastasis discovered 4.5 years after the primary rectal cancer resecti...
Source: Magyar Onkologia - August 31, 2009 Category: Cancer & Oncology Authors: Küronya Z, Bodrogi I, Lövey J, Plótár V, Manninger S, Pápai Z Tags: Magy Onkol Source Type: journals

[Antitumor activity of zoledronic acid.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bisphosphonates are used for supportive treatment in bone metastases of malignant diseases. Advance in various therapeutic options, molecular targeted therapies of malignant diseases result in longer survival, and may bring a higher number of patients surviving until development of secondary lesions, e.g. bone metastases. This review summarizes the antitumor activity of the amino-bisphosphonate zoledronate, describing results of in vitro and animal model studies. Zoledronic acid treatment in patients with malignant solid tumors causing bone metastases prolongs their survival. According to the emerging, until now not to...
Source: Magyar Onkologia - August 31, 2009 Category: Cancer & Oncology Authors: Tamási L Tags: Magy Onkol Source Type: journals

[Claudin expression in different pancreatic cancers and its significance in differential diagnostics.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Claudins (CLDNs) are essential proteins of tight junctions. Changes in their expression pattern have been demonstrated in a number of tumors. CLDNs-3 and -4 are receptors of the Clostridium perfringens enterotoxin, cytolytic effects of the toxin are well known. The aim of our studies was to compare the different CLDN expression patterns in normal pancreas cells, pancreatic endocrine tumors, adenocarcinomas, mucinous cystic tumors and acinar cell carcinomas. Expressions of CLDN-1, -2, -3, -4 and -7 proteins were examined using immunohistochemical as well as RT-PCR techniques and the following observations were made: 1.)...
Source: Magyar Onkologia - August 31, 2009 Category: Cancer & Oncology Authors: Borka K Tags: Magy Onkol Source Type: journals

[Detection of ototoxic effect of cisplatin with otoacoustic emission in testicular cancer patients.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of the research was to detect the acute and long-term ototoxic effect of cisplatin in testicular cancer patients, using OAE (otoacoustic emission), a highly sensitive new objective method, for detecting medication-related hearing loss. Secondary objective was to evaluate the risk factors that contribute to hearing loss. In the study for acute hearing loss ten males with different histological types of testicular germ cell tumor were examined with TOAE (transiently evoked otoacoustic emission), before the 1st and after the 5th day of their 1st cycle of cytostatic therapy. Patients received 100 mg/m 2 cisplatin p...
Source: Magyar Onkologia - August 31, 2009 Category: Cancer & Oncology Authors: Biró K Tags: Magy Onkol Source Type: journals

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PMID: 19793695 [PubMed - in process] (Source: Magyar Onkologia)
Source: Magyar Onkologia - August 31, 2009 Category: Cancer & Oncology Authors: Mayer A Tags: Magy Onkol Source Type: journals

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Authors: PMID: 19793696 [PubMed - in process] (Source: Magyar Onkologia)
Source: Magyar Onkologia - August 31, 2009 Category: Cancer & Oncology Tags: Magy Onkol Source Type: journals

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Authors: PMID: 19793697 [PubMed - in process] (Source: Magyar Onkologia)
Source: Magyar Onkologia - August 31, 2009 Category: Cancer & Oncology Tags: Magy Onkol Source Type: journals

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Authors: PMID: 19793698 [PubMed - in process] (Source: Magyar Onkologia)
Source: Magyar Onkologia - August 31, 2009 Category: Cancer & Oncology Tags: Magy Onkol Source Type: journals

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Authors: PMID: 19793699 [PubMed - in process] (Source: Magyar Onkologia)
Source: Magyar Onkologia - August 31, 2009 Category: Cancer & Oncology Tags: Magy Onkol Source Type: journals

[Chemotherapy of elderly patients with colorectal cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Elderly patients will be the largest group of oncology patients in the future. Because of minimal participation of older patients in randomized clinical trials there is a lack of evidence-based data to make correct decisions with regard to chemotherapy and/or targeted therapy in this age group. Elderly patients have similar benefits from systemic therapies as younger counterparts, but many elders have substantial co-morbidities, which may limit the life expectancy and the effectiveness of systemic therapy. Close collaboration between oncologists and geriatrists will help make decisions on the management of elderly pati...
Source: Magyar Onkologia - May 31, 2009 Category: Cancer & Oncology Authors: Landherr L, Nagykálnai T Tags: Magy Onkol Source Type: journals

[The significance of elastic staining in detecting vascular invasion in colorectal carcinoma]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Venous invasion (VI) is one of the most important prognostic factors in colorectal carcinomas (CRC). The interobserver variation of this feature varies between 10% and 89.5%, mainly due to the specimen processing and staining. VI was assessed using haematoxylin and eosin (H+E) alone in 611 cases and with elastic stain (orcein-haematoxylin) in 243 CRCs. The stage, the pattern of invasion and the presence of intramural and extramural VI were determined. VI was identified in 27.45% of the H+E stained sections and in 67.1% using elastic stain counterstained with haematoxylin. The incidence of VI proved stage dependent as i...
Source: Magyar Onkologia - May 31, 2009 Category: Cancer & Oncology Authors: Bogner B, Hegedûs G Tags: Magy Onkol Source Type: journals

[Diagnostic problems of ovarian mucinous borderline tumors]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
About 15-20% of all ovarian epithelial neoplasms are of borderline type (or atypical proliferative or carcinoma of low malignant potential) and about 5-7% are mucinous type, which are the second most common type behind the serous borderline tumors. The borderline tumor is a serious diagnostic and treatment problem both for the pathologists and for clinicians. These tumors appeared to be intermediate in their histologic and prognostic features between the benign cystadenomas and clearly malignant carcinomas. The borderline tumors occur most commonly in childbearing age, and show an indolent course. Their prognosis is go...
Source: Magyar Onkologia - May 31, 2009 Category: Cancer & Oncology Authors: Vereczkey I, Tóth E, Orosz Z Tags: Magy Onkol Source Type: journals

[Panitumumab-treatment of metastatic colorectal cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the molecular target treatment strategy of metastatic colorectal cancer patients panitumumab represents a new class of drugs due to its fully human nature, and no need for premedication and loading dose. Panitumumab binds to epidermal growth factor receptor (EGFR) selectively. In registration pivotal studies the analysis of patient subgroups for KRAS status gives strong evidence for the important role of RAS oncogene: median progression-free survival was 16 weeks on panitumumab arm in KRAS wild-type patients (8 weeks in best supportive care), while in KRAS mutant patients panitumumab showed no efficacy, however adve...
Source: Magyar Onkologia - May 31, 2009 Category: Cancer & Oncology Authors: Pikó B Tags: Magy Onkol Source Type: journals

[The role of oncology nurses in treatment outcomes. What can we do for the patients' compliance treated with intravenous zoledronic acid?]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with cancer and bone metastasis usually need to be treated with bisphosphonates to reduce or delay skeletal complications (pathologic fracture, hypercalcemia, surgery or radiotherapy). The nurses can provide important education to patients, support and encourage use of bisphosphonates throughout therapy. Literatures, training, congress reports provide useful information about bisphosphonate therapy, side effects, adverse events etc. However, patients need more information to support them during courses. To optimize the care, nurses can monitor pain scores, changes in mobility, adverse events, creating clearanc...
Source: Magyar Onkologia - May 31, 2009 Category: Cancer & Oncology Authors: Zatkóné Puskás G Tags: Magy Onkol Source Type: journals

[Post-transplantation malignant tumors and the challenges of immunosuppressive therapy in transplanted patients developing lymphoma. Mycophenolic acid as a possibility]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The increasing frequency of malignant tumors developing during chronic immunosuppression is an important determinant of the long-term survival of organ transplanted patients. This problem can be solved only if we are aware of the special characteristics concerning our patients. The incidence and frequency of tumors occurring in kidney transplant recipients differ from those of the Hungarian population. The increased tumor risk resulting from chronic renal failure, increasing age of prospective kidney recipients and, in addition, the increasing frequency of tumors diagnosed in the early post-transplantation period empha...
Source: Magyar Onkologia - May 31, 2009 Category: Cancer & Oncology Authors: Végso G Tags: Magy Onkol Source Type: journals

[Cytogenetic and hormonal changes in head and neck squamous cell cancer patients: potential biomarkers for functional approaches in surgical oncology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, potential biomarkers were examined that were thought to develop as biologic responses to the known environmental toxicities, therefore, their testing is supposed to help answer the most important questions of clinical oncology: understanding tumor development, early detection of cancer and individually tailored therapy planning based on the biological nature of a particular cancer. Elevated rate of spontaneous chromosome aberrations proved to be a reliable marker of the SCCHN phenotype. However, increased mutagen sensitivity by the bleomycin-test, unlike in the US or in Western Europe, was not suitable to de...
Source: Magyar Onkologia - May 31, 2009 Category: Cancer & Oncology Authors: Remenár E Tags: Magy Onkol Source Type: journals

[Position statement of the Hungarian Radiotherapy and Oncology College on the insurance coverage of Vectibix (panitumumab)]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19581184 [PubMed - indexed for MEDLINE] (Source: Magyar Onkologia)
Source: Magyar Onkologia - May 31, 2009 Category: Cancer & Oncology Authors: Pikó B, Tags: Magy Onkol Source Type: journals

[Position statement of the Hungarian Radiotherapy and Oncology College on the insurance coverage of Ratiograstim (biocompatible filgrastim)]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19581185 [PubMed - indexed for MEDLINE] (Source: Magyar Onkologia)
Source: Magyar Onkologia - May 31, 2009 Category: Cancer & Oncology Authors: Pikó B, Tags: Magy Onkol Source Type: journals

[Abstracts from the 9th Congress of the Hungarian Radiotherapy Society, Pecs, May 21-23, 2009]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19581187 [PubMed - indexed for MEDLINE] (Source: Magyar Onkologia)
Source: Magyar Onkologia - May 31, 2009 Category: Cancer & Oncology Tags: Magy Onkol Source Type: journals

[Chemotherapy of elderly patients with colorectal cancer.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Elderly patients will be the largest group of oncology patients in the future. Because of minimal participation of older patients in randomized clinical trials there is a lack of evidence-based data to make correct decisions with regard to chemotherapy and/or targeted therapy in this age group. Elderly patients have similar benefits from systemic therapies as younger counterparts, but many elders have substantial co-morbidities, which may limit the life expectancy and the effectiveness of systemic therapy. Close collaboration between oncologists and geriatrists will help make decisions on the management of elderly pati...
Source: Magyar Onkologia - May 31, 2009 Category: Cancer & Oncology Authors: Landherr L, Nagykálnai T Tags: Magy Onkol Source Type: journals

[The importance of elastic staining in detecting vascular invasion in colorectal carcinoma.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Venous invasion (VI) is one of the most important prognostic factors in colorectal carcinomas (CRC). The interobserver variation of this feature varies between 10% and 89.5%, mainly due to the specimen processing and staining. VI was assessed using haematoxylin and eosin (H+E) alone in 611 cases and with elastic stain (orcein-haematoxylin) in 243 CRCs. The stage, the pattern of invasion and the presence of intramural and extramural VI were determined. VI was identified in 27.45% of the H+E stained sections and in 67.1% using elastic stain counterstained with haematoxylin. The incidence of VI proved stage dependent as i...
Source: Magyar Onkologia - May 31, 2009 Category: Cancer & Oncology Authors: Bogner B, Hegedus G Tags: Magy Onkol Source Type: journals

[New bibliometric indicators. Is this the end of the impact factor era?]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
More and more bibliometric indicators emerge beside the impact factor, and a few of them are promising performance indicators. The aim of the study is to show briefly, but clearly the newest bibliometric measure numbers - like the recent enhancements of Journal Citation Report Web, Hirsch-index, Eigenfactor and SCImago Journal & Country Rank algorithms - focusing on the ranking of oncological journals, and to demonstrate the similarities and differences of the results with some examples. There are unified and well-structured web pages behind the newly appeared indicators, and some of the new numbers are presented i...
Source: Magyar Onkologia - May 31, 2009 Category: Cancer & Oncology Authors: Berhidi A, Szluka P, Vasas L Tags: Magy Onkol Source Type: journals

[Diagnostic problems of ovarian mucinous borderline tumors.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
About 15-20% of all ovarian epithelial neoplasms are of borderline type (or atypical proliferative or carcinoma of low malignant potential) and about 5-7% are mucinous type, which are the second most common type behind the serous borderline tumors. The borderline tumor is a serious diagnostic and treatment problem both for the pathologists and for clinicians. These tumors appeared to be intermediate in their histologic and prognostic features between the benign cystadenomas and clearly malignant carcinomas. The borderline tumors occur most commonly in childbearing age, and show an indolent course. Their prognosis is go...
Source: Magyar Onkologia - May 31, 2009 Category: Cancer & Oncology Authors: Vereczkey I, Tóth E, Orosz Z Tags: Magy Onkol Source Type: journals

[Panitumumab-treatment of metastatic colorectal cancer.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the molecular target treatment strategy of metastatic colorectal cancer patients panitumumab represents a new class of drugs due to its fully human nature, and no need for premedication and loading dose. Panitumumab binds to epidermal growth factor receptor (EGFR) selectively. In registration pivotal studies the analysis of patient subgroups for KRAS status gives strong evidence for the important role of RAS oncogene: median progression-free survival was 16 weeks on panitumumab arm in KRAS wild-type patients (8 weeks in best supportive care), while in KRAS mutant patients panitumumab showed no efficacy, however adve...
Source: Magyar Onkologia - May 31, 2009 Category: Cancer & Oncology Authors: Pikó B Tags: Magy Onkol Source Type: journals