Mass Spectrometry ReviewsThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest items in this publication.

Pages: 1 2 3 4 5

207 records returned

The role of mass spectrometry-based metabolomics in medical countermeasures against radiation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Radiation metabolomics can be defined as the global profiling of biological fluids to uncover latent, endogenous small molecules whose concentrations change in a dose-response manner following exposure to ionizing radiation. In response to the potential threat of nuclear or radiological terrorism, the Center for High-Throughput Minimally Invasive Radiation Biodosimetry was established to develop field-deployable biodosimeters based, in part, on rapid analysis by mass spectrometry of readily and easily obtainable biofluids. In this review, we briefly summarize radiation biology and key events related to actual and poten...
Source: Mass Spectrometry Reviews - November 4, 2009 Category: Molecular Biology Authors: Patterson AD, Lanz C, Gonzalez FJ, Idle JR Tags: Mass Spectrom Rev Source Type: journals

The study of ribonucleoproteomics with mass spectrometry (MS)-based technology.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19890945 [PubMed - as supplied by publisher] (Source: Mass Spectrometry Reviews)
Source: Mass Spectrometry Reviews - November 4, 2009 Category: Molecular Biology Authors: Takahashi N Tags: Mass Spectrom Rev Source Type: journals

Controlled band dispersion for quantitative binding determination and analysis with electrospray ionization-mass spectrometry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This review discusses recent emerging techniques that have been used to couple flow-injection analysis (FIA) and electrospray ionization-mass spectrometry (ESI-MS) for the quantitation of noncovalent binding interactions. Focus is placed predominantly on two such methods. Diffusion-based measurements, developed by Konermann and co-workers, uses controlled-band dispersion prior to ESI-MS to determine diffusion constants and binding constants based on the temporal variation of ligand signal measured in the mass spectrum (an indirect technique). Dynamic titration, developed by Schug and co-workers, is a direct method, whe...
Source: Mass Spectrometry Reviews - November 4, 2009 Category: Molecular Biology Authors: Schug KA, Serrano C, Fryčák P Tags: Mass Spectrom Rev Source Type: journals

Mass spectrometry of the photolysis of sulfonylurea herbicides in prairie waters.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This review of mass spectrometry of sulfonylurea herbicides includes a focus on studies relevant to Canadian Prairie waters. Emphasis is given to data gaps in the literature for the rates of photolysis of selected sulfonylurea herbicides in different water matrices. Specifically, results are evaluated for positive ion electrospray tandem mass spectrometry with liquid chromatography separation for the study of the photolysis of chlorsulfuron, tribenuron-methyl, thifensulfuron-methyl, metsulfuron-methyl, and ethametsulfuron-methyl. LC-MS/MS is shown to be the method of choice for the quantification of sulfonylurea herbic...
Source: Mass Spectrometry Reviews - November 4, 2009 Category: Molecular Biology Authors: Headley JV, Du JL, Peru KM, McMartin DW Tags: Mass Spectrom Rev Source Type: journals

Nuclear applications of inorganic mass spectrometry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There are several basic characteristics of mass spectrometry that are not always fully appreciated by the science community. These characteristics include the distinction between relative and absolute isotope abundances, and the influence of isotope fractionation on the accuracy of isotopic measurements. These characteristics can be illustrated in the field of nuclear physics with reference to the measurement of nuclear parameters, which involve the use of enriched isotopes, and to test models of s-, r-, and p-process nucleosynthesis. The power of isotope-dilution mass spectrometry (IDMS) to measure trace elements in p...
Source: Mass Spectrometry Reviews - October 29, 2009 Category: Molecular Biology Authors: De Laeter J Tags: Mass Spectrom Rev Source Type: journals

Application of mass spectrometry in the analysis of polybrominated diphenyl ethers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This review summarized the applications of mass spectrometric techniques for the analysis of the important flame retardants polybrominated diphenyl ethers (PBDEs) to understand the environmental sources, fate and toxicity of PBDEs that were briefly discussed to give a general idea for the need of analytical methodologies. Specific performance of various mass spectrometers hyphenated with, for example, gas chromatograph, liquid chromatograph, and inductively coupled plasma (GC/MS, LC/MS, and ICP/MS, respectively) for the analysis of PBDEs was compared with an objective to present the information on the evolution of MS t...
Source: Mass Spectrometry Reviews - August 30, 2009 Category: Molecular Biology Authors: Wang D, Li QX Tags: Mass Spectrom Rev Source Type: journals

Environmental analysis by inductively coupled plasma mass spectrometry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the numerous ways in which inductively coupled plasma mass spectrometry has been used for the analysis of environmental samples since it was commercially introduced in 1983. Its multielemental isotopic capability, high sensitivity and wide linear dynamic range makes it ideally suited for environmental analysis. Provided that some care is taken during sample preparation and that appropriate calibration strategies are used to circumvent non-spectroscopic interferences, the technique is readily applicable to the analysis of a wide variety of environmental samples (natural waters, soils, rocks, sediments, ...
Source: Mass Spectrometry Reviews - August 30, 2009 Category: Molecular Biology Authors: Beauchemin D Tags: Mass Spectrom Rev Source Type: journals

Canadian mass spectrometry: Environmental and biological applications.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19708013 [PubMed - as supplied by publisher] (Source: Mass Spectrometry Reviews)
Source: Mass Spectrometry Reviews - August 24, 2009 Category: Molecular Biology Authors: Boyd B, Bohme D Tags: Mass Spectrom Rev Source Type: journals

Selected reviews on mass spectrometric topics-CXLIII.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19708014 [PubMed - as supplied by publisher] (Source: Mass Spectrometry Reviews)
Source: Mass Spectrometry Reviews - August 24, 2009 Category: Molecular Biology Authors: Budzikiewicz H Tags: Mass Spectrom Rev Source Type: journals

Liquid chromatography-tandem mass spectrometry applications in endocrinology.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been recognized as a primary methodology for the accurate analysis of endogenous steroid hormones in biological samples. This review focuses on the use of LC-MS/MS in clinical laboratories to assist with the diagnosis of diverse groups of endocrine and metabolic diseases. Described analytical methods use on-line and off-line sample preparation and analytical derivatization to enhance analytical sensitivity, specificity, and clinical utility. Advantages of LC-MS/MS as an analytical technique include high specificity, possibility to simultaneously measure mult...
Source: Mass Spectrometry Reviews - August 24, 2009 Category: Molecular Biology Authors: Kushnir MM, Rockwood AL, Bergquist J Tags: Mass Spectrom Rev Source Type: journals

The analysis of dioxins and related compounds.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The analysis of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, polychlorinated biphenyls, and other related compounds requires complex sample preparation and analytical procedures using highly sensitive and selective state-of-the-art instrumentation to meet very stringent data quality objectives. The analytical procedures (extraction, sample preparation), instrumentation (chromatographic separation and detection by mass spectrometry) and screening techniques for the determination of dioxins, furans, dioxin-like polychlorinated biphenyls and related compounds with a focus on new approaches and alterna...
Source: Mass Spectrometry Reviews - August 10, 2009 Category: Molecular Biology Authors: Reiner EJ Tags: Mass Spectrom Rev Source Type: journals

Mass spectrometry combined with oxidative labeling for exploring protein structure and folding.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This review discusses various mass spectrometry (MS)-based approaches for exploring structural aspects of proteins in solution. Electrospray ionization (ESI)-MS, in particular, has found fascinating applications in this area. For example, when used in conjunction with solution-phase hydrogen/deuterium exchange (HDX), ESI-MS is a highly sensitive tool for probing conformational dynamics. The main focus of this article is a technique that is complementary to HDX, that is, the covalent labeling of proteins by hydroxyl radicals. The reactivity of individual amino acid side chains with (.)OH is strongly affected by their de...
Source: Mass Spectrometry Reviews - August 10, 2009 Category: Molecular Biology Authors: Konermann L, Stocks BB, Pan Y, Tong X Tags: Mass Spectrom Rev Source Type: journals

Atmospheric pressure ion sources.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This review of atmospheric pressure ion sources discusses major developments that have occurred since 1991. Advances in the instrumentation and understanding of the key physical principles are the primary focus. Developments with electrospray and atmospheric pressure chemical ionization and variations encompassing adaptations for surface analysis, ambient air analysis, high throughput, and modification of the ionization mechanism are covered. An important and limiting consequence of atmospheric pressure chemical ionization, chemical noise, is discussed as is techniques being employed to ameliorate the problem. Ion tran...
Source: Mass Spectrometry Reviews - July 21, 2009 Category: Molecular Biology Authors: Covey TR, Thomson BA, Schneider BB Tags: Mass Spectrom Rev Source Type: journals

Advances on the compositional analysis of glycosphingolipids combining thin-layer chromatography with mass spectrometry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glycosphingolipids (GSLs), composed of a hydrophilic carbohydrate chain and a lipophilic ceramide anchor, play pivotal roles in countless biological processes, including infectious diseases and the development of cancer. Knowledge of the number and sequence of monosaccharides and their anomeric configuration and linkage type, which make up the principal items of the glyco code of biologically active carbohydrate chains, is essential for exploring the function of GSLs. As part of the investigation of the vertebrate glycome, GSL analysis is undergoing rapid expansion owing to the application of novel biochemical and biop...
Source: Mass Spectrometry Reviews - July 15, 2009 Category: Molecular Biology Authors: Müthing J, Distler U Tags: Mass Spectrom Rev Source Type: journals

A review of current applications of mass spectrometry for neuroproteomics in epilepsy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The brain is unquestionably the most fascinating organ, and the hippocampus is crucial in memory storage and retrieval and plays an important role in stress response. In temporal lobe epilepsy (TLE), the seizure origin typically involves the hippocampal formation. Despite tremendous progress, current knowledge falls short of being able to explain its function. An emerging approach toward an improved understanding of the complex molecular mechanisms that underlie functions of the brain and hippocampus is neuroproteomics. Mass spectrometry has been widely used to analyze biological samples, and has evolved into an indisp...
Source: Mass Spectrometry Reviews - July 12, 2009 Category: Molecular Biology Authors: Liu X, Wen F, Yang J, Chen L, Wei YQ Tags: Mass Spectrom Rev Source Type: journals

Accurate and precise determination of isotopic ratios by MC-ICP-MS: A review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
For many decades the accurate and precise determination of isotope ratios has remained a very strong interest to many researchers due to its important applications in earth, environmental, biological, archeological, and medical sciences. Traditionally, thermal ionization mass spectrometry (TIMS) has been the technique of choice for achieving the highest accuracy and precision. However, recent developments in multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) have brought a new dimension to this field. In addition to its simple and robust sample introduction, high sample throughput, and high mass r...
Source: Mass Spectrometry Reviews - July 12, 2009 Category: Molecular Biology Authors: Yang L Tags: Mass Spectrom Rev Source Type: journals

Bioimaging of metals by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The distribution analysis of (essential, beneficial, or toxic) metals (e.g., Cu, Fe, Zn, Pb, and others), metalloids, and non-metals in biological tissues is of key interest in life science. Over the past few years, the development and application of several imaging mass spectrometric techniques has been rapidly growing in biology and medicine. Especially, in brain research metalloproteins are in the focus of targeted therapy approaches of neurodegenerative diseases such as Alzheimer's and Parkinson's disease, or stroke, or tumor growth. Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) using doub...
Source: Mass Spectrometry Reviews - June 24, 2009 Category: Molecular Biology Authors: Becker JS, Zoriy M, Matusch A, Wu B, Salber D, Palm C, Becker JS Tags: Mass Spectrom Rev Source Type: journals

Metabolomic applications of HILIC-LC-MS.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hydrophilic interaction liquid chromatography (HILIC), although not a new technique, has enjoyed a recent renaissance with the introduction of robust and reproducible stationary phases. It is consequently finding application in metabolomics studies, which have traditionally relied on the stability of reversed phases (RPs), since the biofluids analyzed are predominantly aqueous and thus contain many polar analytes. HILIC's retention of those polar compounds and use of solvents readily compatible with mass spectrometry have seen its increasing adoption in studies of complex aqueous metabolomes. This review describes the ...
Source: Mass Spectrometry Reviews - June 24, 2009 Category: Molecular Biology Authors: Cubbon S, Antonio C, Wilson J, Thomas-Oates J Tags: Mass Spectrom Rev Source Type: journals

Calcium isotope analysis by mass spectrometry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The variations in the isotopic composition of calcium caused by fractionation in heterogeneous systems and by nuclear reactions can provide insight into numerous biological, geological, and cosmic processes, and therefore isotopic analysis finds a wide spectrum of applications in cosmo- and geochemistry, paleoclimatic, nutritional, and biomedical studies. The measurement of calcium isotopic abundances in natural samples has challenged the analysts for more than three decades. Practically all Ca isotopes suffer from significant isobaric interferences, whereas low-abundant isotopes can be particularly affected by neighbo...
Source: Mass Spectrometry Reviews - June 22, 2009 Category: Molecular Biology Authors: Boulyga SF Tags: Mass Spectrom Rev Source Type: journals

Electrospray: From ions in solution to ions in the gas phase, what we know now.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There is an advantage for users of electrospray and nanospray mass spectrometry to have an understanding of the processes involved in the conversion of the ions present in the solution to ions in the gas phase. The following processes are considered: Creation of charge droplets at the capillary tip; Electrical potentials required and possibility of gas discharges; Evolution of charged droplets, due to solvent evaporation and Coulomb explosions, to very small droplets that are the precursors of the gas phase ions; Production of gas phase ions from these droplets via the Ion Evaporation and Charge residue models; Analyti...
Source: Mass Spectrometry Reviews - June 22, 2009 Category: Molecular Biology Authors: Kebarle P, Verkerk UH Tags: Mass Spectrom Rev Source Type: journals

Selected reviews on mass spectrometric topics.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19551806 [PubMed - as supplied by publisher] (Source: Mass Spectrometry Reviews)
Source: Mass Spectrometry Reviews - June 22, 2009 Category: Molecular Biology Authors: Budzikiewicz H Tags: Mass Spectrom Rev Source Type: journals

Editorial: Canadian mass spectrometry: Instrumentation development.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19548303 [PubMed - as supplied by publisher] (Source: Mass Spectrometry Reviews)
Source: Mass Spectrometry Reviews - June 21, 2009 Category: Molecular Biology Authors: Bohme D, Boyd B Tags: Mass Spectrom Rev Source Type: journals

Microchip technology in mass spectrometry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Microfabrication of analytical devices is currently of growing interest and many microfabricated instruments have also entered the field of mass spectrometry (MS). Various (atmospheric pressure) ion sources as well as mass analyzers have been developed exploiting microfabrication techniques. The most common approach thus far has been the miniaturization of the electrospray ion source and its integration with various separation and sampling units. Other ionization techniques, mainly atmospheric pressure chemical ionization and photoionization, have also been subject to miniaturization, though they have not attracted as ...
Source: Mass Spectrometry Reviews - June 9, 2009 Category: Molecular Biology Authors: Sikanen T, Franssila S, Kauppila TJ, Kostiainen R, Kotiaho T, Ketola RA Tags: Mass Spectrom Rev Source Type: journals

Linear quadrupoles in mass spectrometry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of linear quadrupoles in mass spectrometry as mass filters and ion guides is reviewed. Following a tutorial review of the principles of mass filter operation, methods of mass analysis are reviewed. Discussed are extensions of quadrupole mass filters to higher masses, scanning with frequency sweeps of the quadrupole waveform, operation in higher stability regions, and operation with rectangular or other periodic waveforms. Two relatively new methods of mass analysis the use of "islands of stability" and "mass selective axial ejection" are then reviewed. The optimal electrode geometry for a quadrupole mass filter...
Source: Mass Spectrometry Reviews - June 2, 2009 Category: Molecular Biology Authors: Douglas DJ Tags: Mass Spectrom Rev Source Type: journals

ICP-MS-Based strategies for protein quantification.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the post-genomics era, proteomics has become a central branch in life sciences. An understanding of biological functions will not only rely on protein identification, but also on protein quantification in a living organism. Most of the existing methods for quantitative proteomics are based on isotope labeling combined with molecular mass spectrometry. Recently, a remarkable progress that utilizes inductively coupled plasma-mass spectrometry (ICP-MS) as an attractive complement to electrospray MS and MALDI MS for protein quantification, especially for absolute quantification, has been achieved. This review will selec...
Source: Mass Spectrometry Reviews - June 2, 2009 Category: Molecular Biology Authors: Wang M, Feng WY, Zhao YL, Chai ZF Tags: Mass Spectrom Rev Source Type: journals

Quadrupole ion traps.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The extraordinary story of the three-dimensional radiofrequency quadrupole ion trap, accompanied by a seemingly unintelligible theoretical treatment, is told in some detail because of the quite considerable degree of commercial success that quadrupole technology has achieved. The quadrupole ion trap, often used in conjunction with a quadrupole mass filter, remained a laboratory curiosity until 1979 when, at the American Society for Mass Spectrometry Conference in Seattle, George Stafford, Jr., of Finnigan Corp., learned of the Masters' study of Allison Armitage of a combined quadrupole ion trap/quadrupole mass filter i...
Source: Mass Spectrometry Reviews - June 2, 2009 Category: Molecular Biology Authors: March RE Tags: Mass Spectrom Rev Source Type: journals

Nanoelectrospray emitters: Trends and perspective.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the development of nanoelectrospray emitters, including factors such as geometry and the manner of applying voltage. Designs for emitters that take advantage of multielectrospray are emphasized. (c) 2009 Wiley Periodicals, Inc. Mass Spec Rev. PMID: 19479726 [PubMed - as supplied by publisher] (Source: Mass Spectrometry Reviews)
Source: Mass Spectrometry Reviews - May 28, 2009 Category: Molecular Biology Authors: Gibson GT, Mugo SM, Oleschuk RD Tags: Mass Spectrom Rev Source Type: journals

Cluster secondary ion mass spectrometry of polymers and related materials.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cluster secondary ion mass spectrometry (cluster SIMS) has played a critical role in the characterization of polymeric materials over the last decade, allowing for the ability to obtain spatially resolved surface and in-depth molecular information from many polymer systems. With the advent of new molecular sources such as ${\rm C}_{60}; +$, ${\rm Au}_3; +$, ${\rm SF}_5; +$, and ${\rm Bi}_3; +$, there are considerable increases in secondary ion signal as compared to more conventional atomic beams (Ar(+), Cs(+), or Ga(+)). In addition, compositional depth profiling in organic and polymeric systems is now feasible, withou...
Source: Mass Spectrometry Reviews - May 15, 2009 Category: Molecular Biology Authors: Mahoney CM Tags: Mass Spectrom Rev Source Type: journals

Proteomics of the photoneuroendocrine circadian system of the brain.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The photoneuroendocrine circadian system of the brain consists of (a) specialized photoreceptors in the retina, (b) a circadian generator located in the forebrain that contains "clock genes," (c) specialized nuclei in the forebrain involved in neuroendocrine secretion, and (d) the pineal gland. The circadian generator is a nucleus, called the suprachiasmatic nucleus (SCN). The neurons of this nucleus contain "clock genes," the transcription of which exhibits a circadian rhythm. Most circadian rhythms are generated by the neurons of this nucleus and, via neuronal and humoral connections, the SCN controls circadian activ...
Source: Mass Spectrometry Reviews - May 12, 2009 Category: Molecular Biology Authors: Møller M, Lund-Andersen C, Rovsing L, Sparre T, Bache N, Roepstorff P, Vorum H Tags: Mass Spectrom Rev Source Type: journals

In vivo monitoring of the transfer kinetics of trace elements in animal brains with hyphenated inductively coupled plasma mass spectrometry techniques.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the research relevant to the development of analytical techniques for the in vivo determination of dynamic variation in the concentration levels of metal ions in a living animal. (c) 2009 Wiley Periodicals, Inc. Mass Spec Rev. PMID: 19437493 [PubMed - as supplied by publisher] (Source: Mass Spectrometry Reviews)
Source: Mass Spectrometry Reviews - May 12, 2009 Category: Molecular Biology Authors: Su CK, Sun YC, Tzeng SF, Yang CS, Wang CY, Yang MH Tags: Mass Spectrom Rev Source Type: journals

Selected reviews on mass spectrometric topics-CXLI.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19431185 [PubMed - as supplied by publisher] (Source: Mass Spectrometry Reviews)
Source: Mass Spectrometry Reviews - May 8, 2009 Category: Molecular Biology Authors: Budzikiewicz H Tags: Mass Spectrom Rev Source Type: journals

Radical cations of amino acids and peptides: Structures and stabilities.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Amino acid and peptide radical cations, M(.+), are formed by oxidative dissociations of [Cu(auxiliary ligand)(M)](.2+) and [Metal(III)(salen)(M)](+) complexes. The most easily formed radicals contain either an aromatic or basic amino acid residue. Aromatic amino acids have low ionization energies, are easily oxidized and delocalize the charge and spin over the ring systems; basic amino acids facilitate formation of alpha-radicals that have captodative structures in which the charge and spin are formally separated, although feeding back some of the charge onto the amide or carboxyl group adjacent to the radical center t...
Source: Mass Spectrometry Reviews - April 23, 2009 Category: Molecular Biology Authors: Hopkinson AC Tags: Mass Spectrom Rev Source Type: journals

The ion funnel: Theory, implementations, and applications.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The electrodynamic ion funnel has enabled the manipulation and focusing of ions in a pressure regime (0.1-30 Torr) that has challenged traditional approaches, and provided the basis for much greater mass spectrometer ion transmission efficiencies. The initial ion funnel implementations aimed to efficiently capture ions in the expanding gas jet of an electrospray ionization interface and radially focus them for efficient transfer through a conductance limiting orifice. We review the improvements in fundamental understanding of ion motion in ion funnels, the evolution in its implementations that have brought the ion funn...
Source: Mass Spectrometry Reviews - April 23, 2009 Category: Molecular Biology Authors: Kelly RT, Tolmachev AV, Page JS, Tang K, Smith RD Tags: Mass Spectrom Rev Source Type: journals

Recent advances in mass spectrometry analysis of phenolic endocrine disruptors and related compounds.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews recent literature on current methodologies based on chromatography coupled to mass spectrometry to analyze phenolic compounds with endocrine-disrupting capabilities. For this review we chose alkylphenol ethoxylates, bisphenol A, bisphenol F, and their degradation products and halogenated derivatives, which are considered important environmental contaminants. Additionally, some related compounds such as bisphenol diglycidylethers were included. Growing attention has been paid to the mass spectrometric characterization of these compounds and the instrumentation and strategies used for their quantificatio...
Source: Mass Spectrometry Reviews - April 14, 2009 Category: Molecular Biology Authors: Gallart-Ayala H, Moyano E, Galceran MT Tags: Mass Spectrom Rev Source Type: journals

Glycoproteomics in neurodegenerative diseases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Protein glycosylation regulates protein function and cellular distribution. Additionally, aberrant protein glycosylations have been recognized to play major roles in human disorders, including neurodegenerative diseases. Glycoproteomics, a branch of proteomics that catalogs and quantifies glycoproteins, provides a powerful means to systematically profile the glycopeptides or glycoproteins of a complex mixture that are highly enriched in body fluids, and therefore, carry great potential to be diagnostic and/or prognostic markers. Application of this mass spectrometry-based technology to the study of neurodegenerative di...
Source: Mass Spectrometry Reviews - April 8, 2009 Category: Molecular Biology Authors: Hwang H, Zhang J, Chung KA, Leverenz JB, Zabetian CP, Peskind ER, Jankovic J, Su Z, Hancock AM, Pan C, Montine TJ, Pan S, Nutt J, Albin R, Gearing M, Beyer RP, Shi M, Zhang J Tags: Mass Spectrom Rev Source Type: journals

Structures, energetics, and dynamics of gas phase ions studied by FTICR and HPMS.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Both Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) and high-pressure mass spectrometry (HPMS) are very powerful tools in the field of gas phase ion chemistry. Many experimental method developments based on FTICR-MS and HPMS are summarized, including the coupling of a high-pressure external ion source to a FTICR mass spectrometer, blackbody infrared radiative dissociation (BIRD), coupling laser desorption ionization with HPMS, infrared multiple photon dissociation (IRMPD), radiative association and bimolecular routes to gas phase cluster ion formation. An abundance of thermochemical data, such a...
Source: Mass Spectrometry Reviews - April 7, 2009 Category: Molecular Biology Authors: Wu R, McMahon TB Tags: Mass Spectrom Rev Source Type: journals

Infrared consequence spectroscopy of gaseous protonated and metal ion cationized complexes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this article, the new and exciting techniques of infrared consequence spectroscopy (sometimes called action spectroscopy) of gaseous ions are reviewed. These techniques include vibrational predissociation spectroscopy and infrared multiple photon dissociation spectroscopy and they typically complement one another in the systems studied and the information gained. In recent years infrared consequence spectroscopy has provided long-awaited direct evidence into the structures of gaseous ions from organometallic species to strong ionic hydrogen bonded structures to large biomolecules. Much is being learned with respect ...
Source: Mass Spectrometry Reviews - April 2, 2009 Category: Molecular Biology Authors: Fridgen TD Tags: Mass Spectrom Rev Source Type: journals

To b or not to b: The ongoing saga of peptide b ions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Modern soft ionization techniques readily produce protonated or multiply protonated peptides. Collision-induced dissociation (CID) of these protonated species is often used as a method to obtain sequence information. In many cases fragmentation occurs at amide bonds. When the charge resides on the C-terminal fragment so-called y ions are produced which are known to be protonated amino acids or truncated peptides. When the charge resides on the N-terminal fragment so-called b ions are produced. Often the sequence of y and b ions are essential for peptide sequencing. The b ions have many possible structures, a knowledge ...
Source: Mass Spectrometry Reviews - March 31, 2009 Category: Molecular Biology Authors: Harrison AG Tags: Mass Spectrom Rev Source Type: journals

The mechanisms of collisional activation of ions in mass spectrometry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article is a review of the mechanisms responsible for collisional activation of ions in mass spectrometers. Part I gives a general introduction to the processes occurring when a projectile ion and neutral target collide. The theoretical background to the physical phenomena of curve-crossing excitation (for electronic and vibrational excitation), impulsive collisions (for direct translational to vibrational energy transfer), and the formation of long-lived collision intermediates is presented. Part II highlights the experimental and computational investigations that have been made into collisional activation for four e...
Source: Mass Spectrometry Reviews - March 26, 2009 Category: Molecular Biology Authors: Mayer PM, Poon C Tags: Mass Spectrom Rev Source Type: journals

Editorial: Canadian mass spectrometry: Gaseous ions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19326442 [PubMed - as supplied by publisher] (Source: Mass Spectrometry Reviews)
Source: Mass Spectrometry Reviews - March 26, 2009 Category: Molecular Biology Authors: Boyd B, Bohme D Tags: Mass Spectrom Rev Source Type: journals

Identification and characterization of molecular targets of natural products by mass spectrometry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Natural products, and their derivatives and mimics, have contributed to the development of important therapeutics to combat diseases such as infections and cancers over the past decades. The value of natural products to modern drug discovery is still considerable. However, its development is hampered by a lack of a mechanistic understanding of their molecular action, as opposed to the emerging molecule-targeted therapeutics that are tailored to a specific protein target(s). Recent advances in the mass spectrometry-based proteomic approaches have the potential to offer unprecedented insights into the molecular action of...
Source: Mass Spectrometry Reviews - March 24, 2009 Category: Molecular Biology Authors: Cheng KW, Wong CC, Wang M, He QY, Chen F Tags: Mass Spectrom Rev Source Type: journals

Editorial: Photodissociation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19306312 [PubMed - as supplied by publisher] (Source: Mass Spectrometry Reviews)
Source: Mass Spectrometry Reviews - March 20, 2009 Category: Molecular Biology Authors: Brodbelt J Tags: Mass Spectrom Rev Source Type: journals

Proteomics of regulated secretory organelles.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Regulated secretory organelles are important subcellular structures of living cells that allow the release in the extracellular space of crucial compounds, such as hormones and neurotransmitters. Therefore, the regulation of biogenesis, trafficking, and exocytosis of regulated secretory organelles has been intensively studied during the last 30 years. However, due to the large number of different regulated secretory organelles, only a few of them have been specifically characterized. New insights into regulated secretory organelles open crucial perspectives for a better comprehension of the mechanisms that govern cell ...
Source: Mass Spectrometry Reviews - March 19, 2009 Category: Molecular Biology Authors: Brunner Y, Schvartz D, Couté Y, Sanchez JC Tags: Mass Spectrom Rev Source Type: journals

Neutral and ion thermochemistry: Its present status and significance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This short account outlines the sources of thermochemical data that are important for gas phase ion chemistry. It describes some of the relationships that have been identified for the empirical estimation of enthalpies among neutral molecules, free radicals, and odd and even electron ions. For neutral species, the additivity principle works well and this has been developed to cover a very wide range of structures and isomers. Ionization energies of homologous species depend inversely on molecular size, allowing estimates to be made for missing members. For ions, the effect of a group substitution (such as replacing a h...
Source: Mass Spectrometry Reviews - March 17, 2009 Category: Molecular Biology Authors: Holmes JL, Aubry C Tags: Mass Spectrom Rev Source Type: journals

The Sod2 mutant mouse as a model for oxidative stress: A functional proteomics perspective.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oxidative stress has been implicated in the pathogenesis of numerous human diseases and disorders, but the mechanistic basis often remains enigmatic. The Sod2 mutant mouse, which is sensitized to mitochondrial stress, is an ideal mutant model for studying the role of oxidative stress in a diverse range of complications arising from mitochondrial dysfunction and diminished antioxidant defense. To fully appreciate the widespread molecular consequences under increased oxidative stress, a systems approach utilizing proteomics is able to provide a global overview of the complex biological changes, which a targeted single bi...
Source: Mass Spectrometry Reviews - March 17, 2009 Category: Molecular Biology Authors: Lee YH, Lin Q, Boelsterli UA, Chung MC Tags: Mass Spectrom Rev Source Type: journals

Infrared multiphoton dissociation in quadrupole ion traps.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The development of new ion activation techniques continues to be a dynamic area of scientific discovery, in part to complement the tremendous innovations in ionization methods that have allowed the mass spectrometric analysis of an enormous array of molecules. Ion activation/dissociation provides key information about ion structures, binding energies, and differentiation of isomers, as well as affording a primary means of identifying compounds in mixtures. Numerous new activation methods have emerged over the past two decades in an effort to develop alternatives to collisional activated dissociation, the gold standard ...
Source: Mass Spectrometry Reviews - March 17, 2009 Category: Molecular Biology Authors: Brodbelt JS, Wilson JJ Tags: Mass Spectrom Rev Source Type: journals

Selected reviews on mass spectrometric topics-CXL.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19266564 [PubMed - as supplied by publisher] (Source: Mass Spectrometry Reviews)
Source: Mass Spectrometry Reviews - March 5, 2009 Category: Molecular Biology Authors: Budzikiewicz H Tags: Mass Spectrom Rev Source Type: journals

Buckminsterfullerene cations: New dimensions in gas-phase ion chemistry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The author provides a brief overview, and shares the extraordinary excitement, of the years of unprecedented discoveries in ion chemistry that followed the first production of fullerene powder in 1990. Various charge states of the buckminsterfullerene ${\rm C}_{60};{n + }$ cation became available by conventional electron-impact ionization of the vapor of this powder and so for mass-spectrometric measurements of ion reactivity. The emphasis here will be on fullerene-ion research performed in the author's own laboratory at York University using electron ionization flow-tube mass spectrometry techniques. (c) 2009 Wiley Pe...
Source: Mass Spectrometry Reviews - March 5, 2009 Category: Molecular Biology Authors: Bohme DK Tags: Mass Spectrom Rev Source Type: journals

Techniques for phosphopeptide enrichment prior to analysis by mass spectrometry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mass spectrometry is the tool of choice to investigate protein phosphorylation, which plays a vital role in cell regulation and diseases such as cancer. However, low abundances of phosphopeptides and low degrees of phosphorylation typically necessitate isolation and concentration of phosphopeptides prior to MS analysis. This review discusses the enrichment of phosphopeptides with immobilized metal affinity chromatography, reversible covalent binding, and metal oxide affinity chromatography. Capture of phosphopeptides on TiO(2) seems especially promising in terms of selectivity and recovery, but the success of all metho...
Source: Mass Spectrometry Reviews - March 4, 2009 Category: Molecular Biology Authors: Dunn JD, Reid GE, Bruening ML Tags: Mass Spectrom Rev Source Type: journals

Vibrational spectroscopy of bare and solvated ionic complexes of biological relevance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The low density of ions in mass spectrometers generally precludes direct infrared (IR) absorption measurements. The IR spectrum of an ion can nonetheless be obtained by inducing photodissociation of the ion using a high-intensity tunable laser. The emergence of free electron lasers (FELs) and recent breakthroughs in bench-top lasers based on nonlinear optics have now made it possible to routinely record IR spectra of gas-phase ions. As the energy of one IR photon is insufficient to cause dissociation of molecules and strongly bound complexes, two main experimental strategies have been developed to effect photodissociat...
Source: Mass Spectrometry Reviews - February 24, 2009 Category: Molecular Biology Authors: Polfer NC, Oomens J Tags: Mass Spectrom Rev Source Type: journals