Blood Calcium, Genetic Risk, and Risk of Incident Kidney Stone: A Population-Based Cohort Study
To investigate the association between blood calcium concentration and incident kidney stone as well as to assess the role played by genetic susceptibility. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 16, 2024 Category: Internal Medicine Authors: Xi Cao, Si Li, Yunlong Guan, Zhonghe Shao, Minghui Jiang, Miao Wang, Xingjie Hao Tags: Original Article Source Type: research
Incident Diuretic Use and Subsequent Risk of Bone Fractures
To investigate the association of incident use of diuretics with subsequent risk of incident bone fractures. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 3, 2024 Category: Internal Medicine Authors: Keiichi Sumida, Prabin Shrestha, Yamini Mallisetty, Satya Surbhi, Fridtjof Thomas, Elani Streja, Kamyar Kalantar-Zadeh, Csaba P. Kovesdy Tags: Original article Source Type: research
Predicting Primary Care Physician Burnout From Electronic Health Record Use Measures
To evaluate the ability of routinely collected electronic health record (EHR) use measures to predict clinical work units at increased risk of burnout and potentially most in need of targeted interventions. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 3, 2024 Category: Internal Medicine Authors: Daniel Tawfik, Mohsen Bayati, Jessica Liu, Liem Nguyen, Amrita Sinha, Thomas Kannampallil, Tait Shanafelt, Jochen Profit Tags: Original article Source Type: research
Advancing Translation of Clinical Research Into Practice and Population Health Impact Through Implementation Science
Translational and implementation sciences aim to prioritize and guide efforts to create greater efficiency and speed of scientific innovation across the translational science continuum to improve patient and population health. Key principles and practices rooted in translational and implementation science may be incorporated into clinical trials research, particularly pragmatic trials, to improve the relevance and impact of scientific innovation. This thematic review intends to raise awareness on the value of translational and implementation science in clinical research and to encourage its use in designing and implementin...
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Lila J. Finney Rutten, Jennifer L. Ridgeway, Joan M. Griffin Tags: Thematic Review on Forward Thinking on Clinical Trials in Clinical Practice Source Type: research
State of Gene Therapy for Monogenic Cardiovascular Diseases
Over the past 2 decades, significant efforts have been made to advance gene therapy into clinical practice. Although successful examples exist in other fields, gene therapy for the treatment of monogenic cardiovascular diseases lags behind. In this review, we (1) highlight a brief history of gene therapy, (2) distinguish between gene silencing, gene replacement, and gene editing technologies, (3) discuss vector modalities used in the field with a special focus on adeno-associated viruses, (4) provide examples of gene therapy approaches in cardiomyopathies, channelopathies, and familial hypercholesterolemia, and (5) present...
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Sahej Bains, John R. Giudicessi, Katja E. Odening, Michael J. Ackerman Tags: Review Source Type: research
Pemphigus Vulgaris
A man in his mid-40s was referred with a 2-week history of painful erosions in his mouth followed by spontaneous fragile blisters on his trunk and extremities, resulting in painful erosions. Physical examination demonstrated oral lesions, widespread skin erosions, crusted lesions, and flaccid bullae over his body (Figure 1). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Nika Kianfar, Maryam Daneshpazhooh, Julia S. Lehman Tags: Medical image Source Type: research
Breast Cancer Screening Recommendations for Transgender Patients: A Review
Shifting societal attitudes trending toward increased acceptance of transgender people has contributed to a growth in the population of individuals who openly identify as transgender as well as an increase in utilization of gender-affirming surgeries. Therefore, health care providers should work toward increasing their knowledge with respect to the health care needs of the transgender population, particularly given that these individuals often face discrimination in the health care system. Moreover, transgender breast cancer screening rates lag behind breast cancer screening rates for cisgender individuals. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Alex Suarez, Julia Bisschops, Katharine Lampen-Sachar Tags: Review Source Type: research
A Cross-Sectional Survey Study of Cannabis Use for Fibromyalgia Symptom Management
To assess the use of cannabis as a symptom management strategy for patients with fibromyalgia. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Abhinav Singla, Christopher V. Anstine, Linda Huang, Jordan K. Rosedahl, Arya B. Mohabbat, Lindsey M. Philpot Tags: Original article Source Type: research
Vitamin D Supplementation: To D or Not to D?
Vitamin D was once considered a panacea for a variety of ailments but now is considered by some to be unimportant. As is often the case, the pendulum swings widely from one extreme to the other. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Robert Joseph Fakheri Tags: Commentary Source Type: research
The Imperative of Clinical Trial Diversity: Lessons From the SARS-CoV-2 Pandemic
The National Academy of Science, Engineering, and Medicine recently published a report on the lack of diversity in clinical trials.1 This concern, highlighting the importance of research equity, proved especially relevant during the COVID-19 pandemic. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Amanda Sinderovsky, Eli Y. Adashi Tags: Letter to the Editor Source Type: research
Eosinophilic Esophagitis: Clinical Pearls for Primary Care Providers and Gastroenterologists
Eosinophilic esophagitis (EoE) is a chronic and progressive immune-mediated esophageal disorder. Given its increasing incidence, it is now a leading cause of dysphagia and food impaction in the United States. Eosinophilic esophagitis is most common in adult White men and has a high concurrence rate with other atopic conditions like allergic rhinitis, bronchial asthma, and eczema. The initial presentation includes symptoms of esophageal dysfunction, classically solid-food dysphagia. Without treatment, inflammation can progress to fibrosis with the formation of strictures, leading to complications such as food impaction. (So...
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Rohit Goyal, Amrit K. Kamboj, Diana L. Snyder Tags: Concise Review Source Type: research
Secondary Involvement of the Urinary Bladder by Endometrial Carcinoma
A woman in her late 50s presented with pelvic pain and on transvaginal ultrasound examination was noted to have a bladder mass. Cystoscopy revealed the presence of a 6.0-cm mass, which was resected. Histopathologic examination revealed the presence of a glandular neoplasm underlying the surface urothelium (Figure 1A, B). No evidence of a precursor urothelial neoplasm, such as urothelial carcinoma in situ or papillary urothelial carcinoma, was identified. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Burak Tekin, Lori A. Erickson, Sounak Gupta Tags: Path to patient image quiz Source Type: research
Rainbow Trout # 5, Brook Trout # 2, Rockfish # 5, Walley # 5 by Bonnie Murray
Art is integrated into the Mayo Clinic environment. Since the original Mayo Clinic Building was finished in 1914, many pieces have been donated or commissioned for patients and staff to enjoy. Each issue of Mayo Clinic Proceedings features a work of art (as interpreted by the author) that is displayed in a building or on the grounds of Mayo Clinic campuses. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Margaret R. Wentz Tags: Art at mayo clinic Source Type: research
Bringing the Potential Benefits of Omega-3 to a Higher Level
Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, the main long-chain omega-3 polyunsaturated fatty acids present in seafood, have been proposed for use in the prevention and treatment of cardiovascular diseases (CVDs). Diet is the primary source of protective fatty acids, but personal preferences and dietary restrictions, among other factors, can prevent people from eating a sufficient amount of food rich in EPA and DHA, so adequate intake of omega-3 fatty acids is not always achieved. Therefore, the use of omega-3 supplements containing EPA and DHA can be recommended to increase EPA and DHA to the appropriate level...
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Jari A. Laukkanen, Aldo A. Bernasconi, Carl J. Lavie Tags: Editorial Source Type: research
Is Medical Cannabis a Solution for Controlling Fibromyalgia Symptoms?
Fibromyalgia syndrome (FMS) represents a complex chronic pain disorder primarily characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive impairment. Because of the complexities it entails, FMS is also manifested with significant challenges in diagnosis and management. Despite numerous approved pharmacologic and nonpharmacologic interventions, the clinical outcomes of patients with FMS remain suboptimal, prompting exploration into new therapeutic modalities. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2024 Category: Internal Medicine Authors: Paula David, Aia Mohsen, Howard Amital Tags: Editorial Source Type: research
