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Cangrelor not CHAMPION for PCI patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two CHAMPION trials show disappointing results for the novel fast-acting intravenous platelet inhibitor cangrelor before or after percutaneous coronary intervention, with no reduction in the rate of death, myocardial infarction, or revascularization at 48 hours compared with clopidogrel treatment. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - November 20, 2009 Category: Internal Medicine Source Type: news

RE-DEEM: Dabigatran causes no safety concerns in phase II ACS trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
When added to dual anti-platelet therapy, the orally administered direct thrombin inhibitor, dabigatran etexilate, results in a “low and acceptable bleeding rate” compared with placebo in patients who have suffered an acute myocardial infarction, according to data presentedat the American Heart Association 2009 Scientific Sessions in, Orlando, Florida, USA. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - November 19, 2009 Category: Internal Medicine Source Type: news

HeartMate II: Continuous-flow left ventricular assist device outperforms pulsatile-flow device in advanced heart failureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A continuous-flow left ventricular assist device achieved superior outcomes to a pulsatile-flow LVAD in patients with advanced heart failure. In the HeartMate II Destination Therapy clinical trial, 2-year survival for patients implanted with the continuous-flow device was more than double that of patients implanted with the pulsatile-flow device. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - November 18, 2009 Category: Internal Medicine Source Type: news

FAIR-HF: Intravenous iron improves chronic heart failure outcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Intravenous iron treatment improves multiple clinical outcomes in patients with chronic heart failure and reduced left ventricular ejection fraction, regardless of whether or not they also have anemia, according to data from the FAIR-HF study. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - November 18, 2009 Category: Internal Medicine Source Type: news

No improvement in post-op CV events with liberal RBC transfusion strategyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A liberal strategy of red blood cell transfusion in cases of moderate anemia does not result in better postoperative cardiovascular outcomes compared with a more restrictive strategy of transfusion based primarily on symptomatic anemia in elderly surgical patients, FOCUS trial results show. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - November 17, 2009 Category: Internal Medicine Source Type: news

CASCADE: No added benefit with clopidogrel for saphenous vein grafts after CABGEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The addition of clopidogrel to aspirin failed to significantly reduce intimal hyperplasia in the saphenous vein grafts of patients who underwent coronary artery bypass graft compared with aspirin alone. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - November 17, 2009 Category: Internal Medicine Source Type: news

PLATO: Ticagrelor benefits seen in STEMI subanalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The investigational oral antiplatelet therapy ticagrelor significantly reduces the risk for major cardiovascular events and all-cause mortality compared with clopidogrel in patients with ST-segment elevation myocardial infarction and planned primary percutaneous coronary intervention, a predefined subanalysis of the PLATO trial shows. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - November 16, 2009 Category: Internal Medicine Source Type: news

POPULAR defines platelet function assays predictive of clopidogrel outcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers report that three available platelet function assays can identify patients receiving dual antiplatelet therapy who are at increased risk for major cardiovascular events related to poor clopidogrel response. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - November 16, 2009 Category: Internal Medicine Source Type: news

CDT should be ‘first-line treatment’ for acute massive PEEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Catheter-directed therapy should be the first-line treatment option for patients with acute, massive pulmonary embolism attending hospitals with experienced physicians, US researchers say. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - November 14, 2009 Category: Internal Medicine Source Type: news

Pulmonary hypertension more common than thought after submassive PEEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Signs or symptoms of pulmonary hypertension may be more common after submassive pulmonary embolism than previously thought, US researchers have found. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - November 13, 2009 Category: Internal Medicine Source Type: news

All obesity measures predict VTE riskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
All measures of obesity predict the risk for venous thrombembolism, not just the most commonly used marker of body mass index, research suggests. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - November 11, 2009 Category: Internal Medicine Source Type: news

Extended PROLONG study follow-up supports continued VKA therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Extended follow-up results of the PROLONG study confirms the benefit of continuing anticoagulation in patients with an elevated D-dimer level 1 month after finishing treatment for idiopathic venous thromboembolism. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - November 9, 2009 Category: Internal Medicine Source Type: news

Coagulation markers predict acute MI outcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with myocardial infarction have higher levels of key coagulation markers at time of hospital admission than healthy individuals, with the highest levels found in patients with a poor outcome, researchers say. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - November 7, 2009 Category: Internal Medicine Source Type: news

D-dimer levels allow short-term PE risk stratificationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
D-dimer levels can help stratify the short-term risk for mortality in patients with pulmonary embolism, Spanish researchers have found. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - November 6, 2009 Category: Internal Medicine Source Type: news

Prothrombin fragment F1+2 linked to atherosclerosis developmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers have found a positive association between carotid artery intima media thickness and levels of prothrombin fragment 1+2 in patients with myocardial infarction. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - November 4, 2009 Category: Internal Medicine Source Type: news

D-dimer testing valuable in renal dysfunction patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
D-dimer testing is worthwhile in patients with mild or moderately impaired renal function and suspicion of pulmonary embolism, Dutch researchers say, even though the test has a significantly lower specificity than in patients with healthy kidneys. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - November 2, 2009 Category: Internal Medicine Source Type: news

LMWH alternative treatment for mechanical valve pregnancy prophylaxisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Low molecular weight heprin is a feasible option for pregnant women with mechanical heart valves who wish to avoid oral anticoagulation therapy, Canadian researchers believe. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - October 30, 2009 Category: Internal Medicine Source Type: news

Guidelines on triple therapy use in ACS need expansionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
US researchers call for improved guidance on use of anticoagulation and dual antiplatelet agent regimens in patients with acute coronary syndromes. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - October 29, 2009 Category: Internal Medicine Source Type: news

F11 SNPs influence DVT riskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Variant forms of the gene encoding factor XI are associated with an increased risk for deep vein thrombosis, shows research published in the Journal of Thormbosis and Haemostasis. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - October 28, 2009 Category: Internal Medicine Source Type: news

DVT origin of PE questioned in trauma patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
US researchers have challenged the belief that pulmonary embolism in trauma patients originates from deep vein thrombosis of the pelvis and proximal lower limb blood vessels. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - October 26, 2009 Category: Internal Medicine Source Type: news

P2Y12 inhibitor overcomes high platelet reactivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A novel direct-acting P2Y12 inhibitor reversibly overcomes high platelet reactivity in patients on clopidogrel and aspirin therapy who have undergone prior coronary stenting, US researchers report. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - October 24, 2009 Category: Internal Medicine Source Type: news

Fixed sub-therapeutic dose LMWH ‘feasible’ for bridging anticoagulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of fixed sub-therapeutic doses of low molecular weight heparin as a bridging regimen in patients on long-term Vitamin-k Antagonist therapy is associated with a low risk for recurrent thrombosis and major bleeding even in high-risk patients, Italian researchers report. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - October 23, 2009 Category: Internal Medicine Source Type: news

Age, BMI, and oral contraceptives predict blood clotting factor activityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Older age and greater body mass index predict the activity of blood clotting factors VIII, FIX, and FXI, while oral contraceptive use predicts FIX, FXI, and FXII activity, report German researchers. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - October 20, 2009 Category: Internal Medicine Source Type: news

Age, congenital heart disease influence coagulation tests in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers have found that whole blood coagulation tests used for monitoring unfractionated heparin vary with age and presence of congenital heart disease in children. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - October 19, 2009 Category: Internal Medicine Source Type: news

Pharmacist review may boost medical VTE prophylaxis useEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pharmacists can improve thromboprophylaxis awareness among physicians treating hospitalized patients, suggest results from a clinical trial. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - October 16, 2009 Category: Internal Medicine Source Type: news

PE risk highlighted in severely ill swine flu patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Computed tomography scanning should be performed in patients severely affected by the swine-origin influenza A virus, say US researchers, who found such patients have an increased risk for pulmonary embolism. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - October 15, 2009 Category: Internal Medicine Source Type: news

Elevated troponin and natriuretic peptides equal poor PE prognosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Results from two meta-analyses shed light on the role of troponins in the prognosis of pulmonary embolism, suggesting that elevated levels are most useful for predicting a poor outcome when combined with high concentrations of natriuretic peptide. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - October 14, 2009 Category: Internal Medicine Source Type: news

Heparin-induced skin reaction frequency highlightedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Heparin-induced skin lesions are more common than previously thought, report researchers who found the reaction associated with overweight, female gender, and longer duration of heparin therapy. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - October 12, 2009 Category: Internal Medicine Source Type: news

Recurrent VTE risk factors do not rule out need for anticoagulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Study findings show that no single risk factor for recurrent venous thromboembolism is able to guide the use of anticoagulation therapy. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - October 10, 2009 Category: Internal Medicine Source Type: news

Early effective anticoagulation required after mitral MHVREmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients undergoing mitral mechanical heart valve replacement have a high risk for early postoperative thromboembolic events, despite systematic use of intravenous unfractionated heparin, French researchers report. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - October 9, 2009 Category: Internal Medicine Source Type: news

Pre-hospital high-dose tirofiban reduces early stent thrombosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pre-hospital initiation of high-dose tirofiban halves the incidence of early stent thrombosis in patients undergoing primary percutaneous coronary intervention with stenting, research shows. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - October 6, 2009 Category: Internal Medicine Source Type: news

Risk for frailty predicted by D-dimer and tPAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
US researchers have found that markers of coagulation and fibrinolysis significantly predict frailty in postmenopausal women. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - October 5, 2009 Category: Internal Medicine Source Type: news

LMWH thromboprophylaxis reduces risk for thrombocytopeniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Heparin-associated thrombocytopenia is uncommon after treatment for venous thrombembolism, but the risk could be reduced further by using low molecular weight heparin, researchers suggest in the American Journal of Medicine. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - October 2, 2009 Category: Internal Medicine Source Type: news

Medical treatment value questioned for operable CTEPHEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Medical pulmonary hypertensive therapy does not benefit most patients with operable chronic thromboembolic pulmonary hypertension, suggest US researchers. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - September 29, 2009 Category: Internal Medicine Source Type: news

Vitamin K diet improves oral anticoagulation controlEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Focusing on diet can help patients achieve stable anticoagulation, say Brazilian researchers. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - September 28, 2009 Category: Internal Medicine Source Type: news

Fibrinolysis efficacy questioned for left-sided PVT in developing countriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Novel treatments are required for patients with left-sided prosthetic valve thrombosis in developing countries, say clinicians on finding fibrinolysis to be less effective for this indication than previously reported. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - September 25, 2009 Category: Internal Medicine Source Type: news

ATTRACT Trial to investigate image-guided DVT treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Image-guided interventional radiology may play an increasing role in the treatment of deep vein thrombosis, suggests a report in the American Journal of Roentgenology. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - September 22, 2009 Category: Internal Medicine Source Type: news

Thrombophilia linked to elevated hemoglobinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Young women carrying the factor V Leiden mutation have elevated hemoglobin levels, say Swedish researchers, who believe the mutation could be an evolutionary quirk. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - September 21, 2009 Category: Internal Medicine Source Type: news

Fondaparinux plus thrombolysis feasible for PE treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The factor Xa inhibitor fondaparinux can be used alongside thrombolysis to treat pulmonary embolism, suggests preliminary French research. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - September 18, 2009 Category: Internal Medicine Source Type: news

SVG occlusion independent of HIT antibodiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
US research indicates that the antibodies that cause heparin-induced thrombocytopenia do not increase the risk for early saphenous vein graft occlusion in patients undergoing coronary artery bypass graft surgery. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - September 15, 2009 Category: Internal Medicine Source Type: news

Variant alleles confer increased risk for VTE in elderlyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Variants coagulation genes may contribute to the increased risk for venous thromboembolism found in older individuals, US researchers suggest. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - September 14, 2009 Category: Internal Medicine Source Type: news

Dual antiplatelet therapy best for low TE risk patients after stentingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oral anticoagulant therapy regimens in percutaneous coronary intervention and stent implantation patients should be tailored to their risk for thromboembolism, researchers suggest. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - September 11, 2009 Category: Internal Medicine Source Type: news

rFVIIa reduces postoperative bleedingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recombinant activated factor VII may reduce bleeding after cardiac surgery, suggest study findings published in the journal Circulation. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - September 10, 2009 Category: Internal Medicine Source Type: news

VTE risk independent of diabetes diagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The risk for venous thromboembolism is not elevated by diabetes or related conditions, US research indicates. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - September 8, 2009 Category: Internal Medicine Source Type: news

Proximal and distal DVT patients differ in mortality riskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with proximal deep vein thrombosis have a higher risk for death than those with distal clots, show results from the OPTIMEV study. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - September 7, 2009 Category: Internal Medicine Source Type: news

TEG results affected by blood acidosis, low tempEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hemostasis testing should take into account patient physiologic factors, say scientists who found that thromboelastography results are affected by blood pH and temperature. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - September 6, 2009 Category: Internal Medicine Source Type: news

Biomarkers predict VTE risk in cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Vienna Cancer and Thrombosis study shows that venous thromboembolism can be predicted in cancer patients using levels of D-dimer and prothrombin fragment 1+2. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - September 3, 2009 Category: Internal Medicine Source Type: news

AAA study finds no benefit of aspirin in asymptomatic atherosclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chronic use of low-dose aspirin does not prevent vascular events in people with asymptomatic atherosclerotic disease detected using the ankle brachial index, study findings show. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - September 1, 2009 Category: Internal Medicine Source Type: news

proCPU levels alter thrombosis risk in thrombophilic patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A variant gene that increases levels of procarboxypeptidase U raises the risk for thrombosis in thrombophilic patients, suggests study findings. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - September 1, 2009 Category: Internal Medicine Source Type: news

RE-LY: Dabigatran lowers stroke risk versus warfarin in AF patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Treatment with dabigatran significantly reduces stroke risk in comparison with warfarin in patients with atrial fibrillation and at least one risk factor, results of the Randomized Evaluation of Long-term anticoagulant therapY trial show. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - September 1, 2009 Category: Internal Medicine Source Type: news