Convenient methods for ingestion of molecular hydrogen: drinking, injection, and inhalation
AbstractMolecular hydrogen (H2) is clinically administered; however, in some hospitals, H2 is given to patients without consideration of its safe use. In the present study, we prepared convenient and safe devices for the drinking of super-saturated H2 water, for intravenous drip infusion of H2-rich saline, and for the inhalation of H2 gas. In order to provide useful information for researchers using these devices, the changes in H2 concentration were studied. Our experimental results should contribute to the advance of non-clinical and clinical research in H2 medicine. (Source: Medical Gas Research)
Source: Medical Gas Research - October 26, 2015 Category: Biomedical Science Source Type: research

Convenient methods for ingestion of molecular hydrogen: drinking, injection, and inhalation
Abstract Molecular hydrogen (H2) is clinically administered; however, in some hospitals, H2 is given to patients without consideration of its safe use. In the present study, we prepared convenient and safe devices for the drinking of super-saturated H2 water, for intravenous drip infusion of H2-rich saline, and for the inhalation of H2 gas. In order to provide useful information for researchers using these devices, the changes in H2 concentration were studied. Our experimental results should contribute to the advance of non-clinical and clinical research in H2 medicine. (Source: Medical Gas Research)
Source: Medical Gas Research - October 26, 2015 Category: Biomedical Science Source Type: research

Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles -
AbstractTherapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. Most studies have been conducted in Japan, China, and the USA. About three-quarters of the articles show the effects in mice and rats. The number of clinical trials is increasing every year. In most diseases, the effect of hydrogen has been reported with hydrogen water or hydrogen gas, which was followed by confirmation of the effect with hydrogen-rich saline. Hydrogen water is mostly givenad libitum. Hydrogen ...
Source: Medical Gas Research - October 19, 2015 Category: Biomedical Science Source Type: research

Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles -
Abstract Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. Most studies have been conducted in Japan, China, and the USA. About three-quarters of the articles show the effects in mice and rats. The number of clinical trials is increasing every year. In most diseases, the effect of hydrogen has been reported with hydrogen water or hydrogen gas, which was followed by confirmation of the effect with hydrogen-rich saline. Hydrogen water is mostly given...
Source: Medical Gas Research - October 19, 2015 Category: Biomedical Science Source Type: research

Does normobaric hyperoxia increase oxidative stress in acute ischemic stroke? A critical review of the literature
AbstractStroke, one of the most debilitating cerebrovascular and nuerological diseases, is a serious life-threatening condition and a leading cause of long-term adult disability and brain damage, either directly or by secondary complications. Most effective treatments for stroke are time dependent such as the only FDA-approved therapy, reperfusion with tissue-type plasminogen activator; thus, improving tissue oxygenation with normobaric hyperoxia (NBO) has been considered a logical and potential important therapy. NBO is considered a good approach because of its potential clinical advantages, and many studies suggest that ...
Source: Medical Gas Research - August 25, 2015 Category: Biomedical Science Source Type: research

Hyperbaric oxygen therapy for post concussion symptoms: issues may affect the results
AbstractPost concussion syndrome (PCS) is a set of symptoms succeeding in 25  % of mild traumatic brain injury (mTBI) patients. Hyperbaric oxygen therapy (HBOT) has been demonstrated as an effective method for treating acute and severe TBI, but its efficacy in PCS remains controversial. In this editorial, we reviewed the clinical studies of HBOT in PCS, summarized the limit ations of these studies, and discussed the limitations: inappropriate Sham group using room air at 1.2 or 1.3 ATA; delayed HBO administration; subjective assessment methods; time point for outcome assessment and small sample size. We hope that our conc...
Source: Medical Gas Research - August 25, 2015 Category: Biomedical Science Source Type: research

Does normobaric hyperoxia increase oxidative stress in acute ischemic stroke? A critical review of the literature
Abstract Stroke, one of the most debilitating cerebrovascular and nuerological diseases, is a serious life-threatening condition and a leading cause of long-term adult disability and brain damage, either directly or by secondary complications. Most effective treatments for stroke are time dependent such as the only FDA-approved therapy, reperfusion with tissue-type plasminogen activator; thus, improving tissue oxygenation with normobaric hyperoxia (NBO) has been considered a logical and potential important therapy. NBO is considered a good approach because of its potential clinical advantages, and many ...
Source: Medical Gas Research - August 24, 2015 Category: Biomedical Science Source Type: research

Hyperbaric oxygen therapy for post concussion symptoms: issues may affect the results
Abstract Post concussion syndrome (PCS) is a set of symptoms succeeding in 25 % of mild traumatic brain injury (mTBI) patients. Hyperbaric oxygen therapy (HBOT) has been demonstrated as an effective method for treating acute and severe TBI, but its efficacy in PCS remains controversial. In this editorial, we reviewed the clinical studies of HBOT in PCS, summarized the limitations of these studies, and discussed the limitations: inappropriate Sham group using room air at 1.2 or 1.3 ATA; delayed HBO administration; subjective assessment methods; time point for outcome assessment and small sample size. We...
Source: Medical Gas Research - August 24, 2015 Category: Biomedical Science Source Type: research

Hyperbaric oxygen in chronic traumatic brain injury: oxygen, pressure, and gene therapy
This article argues that the traditional defin ition of hyperbaric oxygen therapy is arbitrary. The article establishes a scientific definition of hyperbaric oxygen therapy as a wound-healing therapy of combined increased atmospheric pressure and pressure of oxygen over ambient atmospheric pressure and pressure of oxygen whose main mechanisms of action are gene-mediated. Hyperbaric oxygen therapy exerts its wound-healing effects by expression and suppression of thousands of genes. The dominant gene actions are upregulation of trophic and anti-inflammatory genes and down-regulation of pro-inflammatory and apoptotic genes. T...
Source: Medical Gas Research - July 14, 2015 Category: Biomedical Science Source Type: research

Hyperbaric oxygen in chronic traumatic brain injury: oxygen, pressure, and gene therapy
This article argues that the traditional definition of hyperbaric oxygen therapy is arbitrary. The article establishes a scientific definition of hyperbaric oxygen therapy as a wound-healing therapy of combined increased atmospheric pressure and pressure of oxygen over ambient atmospheric pressure and pressure of oxygen whose main mechanisms of action are gene-mediated. Hyperbaric oxygen therapy exerts its wound-healing effects by expression and suppression of thousands of genes. The dominant gene actions are upregulation of trophic and anti-inflammatory genes and down-regulation of pro-inflammatory and apoptotic genes. Th...
Source: Medical Gas Research - July 14, 2015 Category: Biomedical Science Source Type: research

Pharmacokinetic analysis of the chronic administration of the inert gases Xe and Ar using a physiological based model
ConclusionsThe use of standard pharmacokinetics parameters such as area under the curve would be more appropriate to assess the delivered dose of chronic gas administration than the gas concentration in the delivery system that is typically reported in the scientific literature because species and gas differences can result in very different delivered doses. (Source: Medical Gas Research)
Source: Medical Gas Research - May 29, 2015 Category: Biomedical Science Source Type: research

Pharmacokinetic analysis of the chronic administration of the inert gases Xe and Ar using a physiological based model
Conclusions The use of standard pharmacokinetics parameters such as area under the curve would be more appropriate to assess the delivered dose of chronic gas administration than the gas concentration in the delivery system that is typically reported in the scientific literature because species and gas differences can result in very different delivered doses. (Source: Medical Gas Research)
Source: Medical Gas Research - May 29, 2015 Category: Biomedical Science Source Type: research

All the right moves: the need for the timely use of hyperbaric oxygen therapy for treating TBI/CTE/PTSD
DiscussionUp against black-boxed anti-depressants that are not efficacious, it should be a “no-brainer” to use a safe, off-label drug, but in the case of military veterans, every suicide might be seen as a tremendous cost saving to certain technocrats. The unspoken rationale is that if the military were to embrace hyperbaric oxygen as the efficacious therapy that it is then current ac tive troops that have suffered injuries will come forward and seek treatment and benefits for their Traumatic Brain Injuries now that they know there is a viable therapy and in so doing troop strength will be decimated. So, to attempt to ...
Source: Medical Gas Research - May 28, 2015 Category: Biomedical Science Source Type: research

All the right moves: the need for the timely use of hyperbaric oxygen therapy for treating TBI/CTE/PTSD
Discussion Up against black-boxed anti-depressants that are not efficacious, it should be a “no-brainer” to use a safe, off-label drug, but in the case of military veterans, every suicide might be seen as a tremendous cost saving to certain technocrats. The unspoken rationale is that if the military were to embrace hyperbaric oxygen as the efficacious therapy that it is then current active troops that have suffered injuries will come forward and seek treatment and benefits for their Traumatic Brain Injuries now that they know there is a viable therapy and in so doing troop strength will be decimat...
Source: Medical Gas Research - May 28, 2015 Category: Biomedical Science Source Type: research

Hyperbaric oxygen therapy ameliorates TNBS-induced acute distal colitis in rats
ConclusionsThe results indicate that hyperbaric oxygen attenuates the severity of acute distal colitis through the down-regulation of pro-inflammatory events. (Source: Medical Gas Research)
Source: Medical Gas Research - April 16, 2015 Category: Biomedical Science Source Type: research