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Pathologic complete response of a solitary melanoma brain metastasis after local ablative radiation therapy: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A 73-year-old female with malignant melanoma metastatic to her left frontal lobe status post-gross total resection of the metastasis, whole brain radiotherapy, and Gamma Knife-based stereotactic radiosurgery for local recurrence presented with an area of increasing enhancement on follow-up magnetic resonance imaging (MRI) and hypermetabolic lesions on 18-fluorodeoxyglucose positron emission tomography/computerized tomography (18FDG PET/CT) of the brain suspicious for tumor recurrence. Surgical resection of the lesion was performed showing radiation necrosis with no evidence of tumor. The patient was...
Source: Medical Oncology - November 18, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Evaluation of EMMPRIN and MMP-2 in the prognosis of primary cutaneous malignant melanomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of the study was to investigate whether the presence of matrix metalloproteinase-2 (MMP-2) and its inducer, extracellular matrix metalloproteinase inducer (EMMPRIN), in primary cutaneous malignant melanoma (PCMM) might help to predict patient prognosis. Immunohistochemical staining was performed on formalin-fixed, paraffin-embedded sections of PCMM from 150 patients. Association of clinical variables (gender, age, tumor location, thickness, Clark level and AJCC stage) with EMMPRIN and MMP-2 expression were analyzed by Fisher’s exact test. Survival rates were subsequently estimated using th...
Source: Medical Oncology - November 18, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Osteopontin silencing by small interfering RNA induces apoptosis and suppresses invasion in human renal carcinoma Caki-1 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Antiapoptosis and invasion are the causes for the failure of conventional radiotherapy and chemotherapy in human renal carcinomas. Osteopontin (OPN), a ligand for vß3 integrin and CD44 receptors, is a phosphorylated glycoprotein with diverse functions including tumorigenesis and tumor cell metastasis. Recently, OPN has been detected in human renal carcinomas and assessed as a potential prognostic marker of renal carcinomas. However, the function and mechanism of OPN in renal carcinomas remain unknown. In this study, we used OPN siRNA to silence the expression of OPN in renal carcinoma Caki-1 cells....
Source: Medical Oncology - November 18, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Clinical significance of vascular endothelial growth factor and connexin43 for predicting pancreatic cancer clinicopathologic parametersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to find out the expression features of VEGF and Cx43 and their significance in pancreatic cancer. The expression levels of VEGF and Cx43 protein in the samples, which came from 100 patients of human pancreatic cancer tissues and adjacent normal pancreatic tissues, were examined by using immunohistochemical streptavidin–peroxidase (S–P) method, Western-blotting, and RT–PCR analyses. Compared with adjacent normal pancreatic tissues, RT–PCR showed that the expression of VEGF mRNA was significantly higher in pancreatic cancer tissues (0.788 ± 0.290, P < 0.01) and Cx43 mRNA w...
Source: Medical Oncology - November 12, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The medicinal properties of curcumin are well documented in Indian and Chinese systems of medicine, which refer to its wide use in the treatment of some diseases. It has shown to have anti-carcinogenic properties and is known to prevent tumor development in some cancers. In our study, we confirmed that the expression of miR-15a and miR-16 was upregulated and that of Bcl-2 was downregulated in curcumin-treated MCF-7 cells. Silencing miR-15a and miR-16 by specific inhibitors restored the expression of Bcl-2. Thus, we concluded that curcumin can reduce the expression of Bcl-2 by upregulating the expres...
Source: Medical Oncology - November 12, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Interleukin-1beta and tumor necrosis factor-alpha regulation of CDX2 homeobox gene through nuclear factor kappa B-dependent pathway in the intestinal-type gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aims of this study were to reveal the correlation between the transcription factor CDX2 and proinflammatory cytokines interleukin-1beta, tumor necrosis factor-alpha in the gastric cancerous tissues and gastric cancer cell line. Expression of CDX2 and proinflammatory cytokines in the gastric cancer tissues was analyzed by immunohistochemistry, immunoblotting and ELISA. The effect of interleukin-1beta and tumor necrosis factor-alpha on CDX2 messenger RNA, protein and promoter activity was analyzed in gastric cancer cell line AGS using real-time PCR, immunoblotting and EMSA. In the gastric cancerou...
Source: Medical Oncology - November 12, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Gastroenteropancreatic neuroendocrine tumors: 10-year experience in a single centerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigates the clinical, pathologic and prognostic characteristics of gastroenteropancreatic neuroendocrine tumors that presented to the Medical Oncology Outpatient Clinic, İstanbul University, Cerrahpaşa School of Medicine from 1995 to 2006 (n = 86). The mean age of the patients was 52 ± 14 and the male-to-female ratio was 0.87. The most common site of involvement was the stomach. Midgut intestinal tumors seemed to have significant female predominance compared to hindgut intestinal tumors (P = 0.016). Most of the patients had metastatic disease with a prevalence of 34.9%. ...
Source: Medical Oncology - November 11, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Pharmacogenetics and pharmacoepigenetics of gemcitabineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Gemcitabine (2′,2′-difluoro 2′deoxycytidine, dFdC) is an analog of cytosine with distinctive pharmacological properties and a wide antitumor-activity spectrum. The pharmacological characteristics of gemcitabine are unique because two main classes of genes are essential for its antitumor effects: membrane transporter protein-coding genes, whose products are responsible for drug intracellular uptake, as well as enzyme-coding genes, which catalyze its activation and inactivation. The study of the pharmacogenetics and pharmacoepigenetics of these two gene classes is greatly required to optimize th...
Source: Medical Oncology - November 10, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Large-cell neuroendocrine carcinoma of the ampulla of VaterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Large-cell neuroendocrine carcinoma is a high-grade neuroendocrine carcinoma, originally described in the lung. The tumor rarely occurs in extrapulmonary sites like the gastrointestinal tract, and only few examples have been described in the ampulla of Vater. A new case of large-cell neuroendocrine carcinoma of the ampulla of Vater in a 60-year-old man is reported. After pancreatoduodenectomy, macroscopic examination revealed ulcerated tumor in the region of the ampulla of Vater. Microscopically, the tumor exhibited organoid, predominantly nested growth pattern, consisting of large, polygonal cells ...
Source: Medical Oncology - November 7, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

The efficacy of frontline platinum-based combination chemotherapy in advanced adenocarcinoma of the ampulla of VaterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Adenocarcinoma arising from the ampulla of Vater is a rare neoplasm that accounts for only 0.2% of all gastrointestinal tract malignancies and has limited data regarding its frontline therapy. We investigated the treatment outcomes in patients with advanced adenocarcinoma of the ampulla of Vater receiving frontline cisplatin-based combination chemotherapy. We analyzed 29 patients with advanced adenocarcinoma of the ampulla of Vater who had been treated by frontline cisplatin-based combination chemotherapy between June 2003 and April 2008. The chemotherapeutic agent added to cisplatin was gemcitabine...
Source: Medical Oncology - November 7, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Regression of advanced melanoma upon withdrawal of immunosuppression: case series and literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report two cases of stage IV malignant melanoma arising in patients treated with azathioprine for myasthenia gravis. In both cases, the melanoma metastases regressed upon withdrawal of immunosuppression. One patient remains melanoma free at 10 years, and the second patient experienced an 18-month disease free period. There is one prior case report in the medical literature to support full immune reconstitution for treatment in advanced immunosuppression-related melanoma, and one case series suggesting that transplant patients developing melanoma may benefit from a switch to sirolimus. Virtually, no data exist f...
Source: Medical Oncology - November 5, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Upregulation of soluble resistance-related calcium-binding protein (sorcin) in gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of this paper was to identify novel proteins involved in the development of gastric cancer (GC). Isobaric tags for relative and absolute quantification (iTRAQ) analysis was adopted to separate the differentially expressed proteins between normal gastric epithelial cell line GES-1 and GC cell line SGC7901. Western blotting was utilized to validate the increased expression of sorcin in SGC7901; immunohistochemistry was performed to investigate its relationship with clinicopathological features of GC. Twelve differential proteins were identified. Seven proteins were found to be significantly up...
Source: Medical Oncology - November 3, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Neoadjuvant chemotherapy with a combination of docetaxel, cisplatin, fluorouracil, and leucovorin in nonresectable advanced gastric cancer: a short communicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of this study was to evaluate the efficacy and toxicity of docetaxel (TAX), cisplatin (CDDP), and fluorouracil (5-FU) plus leucovorin (CF) as the neoadjuvant chemotherapy (NACT) regimens in the treatment of nonresectable advanced gastric cancer. Twelve patients with nonresectable advanced gastric cancer were treated with NACT regimens consisted of docetaxel, cisplatin, fluorouracil, plus leucovorin before operation. Nine of the 12 patients were downstaged and 8 were radically operated after the end of the NACT. The overall response rate was 75% with 8.3% complete response and 66.7% partial r...
Source: Medical Oncology - November 3, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Blood ABO groups and risk of breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s12032-009-9346-1Authors Didem S. Dede, Hacettepe University Institute of Oncology Department of Medical Oncology Sıhhiye 06100 Ankara TurkeySercan Aksoy, Hacettepe University Institute of Oncology Department of Medical Oncology Sıhhiye 06100 Ankara TurkeyOmer Dizdar, Hacettepe University Institute of Oncology Department of Medical Oncology Sıhhiye 06100 Ankara TurkeyPamir Cerci, Hacettepe University Institute of Oncology Department of Medical Oncology Sıhhiye 06100 Ankara TurkeyIbrahim Gullu, Hacettepe University Institute of Oncology Department ...
Source: Medical Oncology - November 3, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Dasatinib-induced complete molecular response after allogeneic hematopoietic stem cell transplantation in Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to prior imatinib-containing regimen: a case report and discussionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Presence of the Philadelphia chromosome in acute lymphoblastic leukemia is the single most adverse prognostic marker associated with high risk of disease relapse and poor prognosis. Allogeneic haematopoietic stem cell transplantation is considered as the only curative option in adults with Philadelphia-positive acute lymphoblastic leukemia, but relapse remains the main cause of treatment failure. Moreover, long-term survival rates are markedly decreased when transplanted patients are not in complete remission. Incorporation of tyrosine kinase inhibitors into transplantation strategy in patients with...
Source: Medical Oncology - November 3, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Determining of metastatic lymph node ratio in patients who underwent D2 dissection for gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The purpose of this study was to determine outcome of the ratio of metastatic lymph nodes to the total number of dissected lymph nodes (MLR) in patients with gastric cancer. We retrospectively analyzed 111 patients who underwent D2 lymph node dissection. The prognostic factors including UICC/AJCC TNM classification and MLR were evaluated by univariate and multivariate analysis. The MLR was significantly higher in patients with a larger tumor, lymphatic vessel invasion, blood vessel invasion and perineural invasion, and advanced stage. Moreover, the MLR was significantly associated with the depth of ...
Source: Medical Oncology - November 3, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Prophylaxis with itraconazole is more effective than prophylaxis with fluconazole in neutropenic patients with hematological malignancies: a meta-analysis of randomized-controlled trialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Antifungal prophylaxis using fluconazole or itraconazole has been studied for many years but still no consensus has been reached regarding their safety and effectiveness. We performed a systematic meta-analysis to assess the efficacy of fluconazole compared to itraconazole in neutropenic patients with hematological malignancies. We gathered the data for our analysis from MEDLINE, EMBASE, Cochrane-controlled trials register, Cochrane Library, and Science Citation Index (1/1990 to 1/2009) searches. Risk ratio (RR) and 95% confidence intervals (CIs) were calculated using the random effect model. Nine R...
Source: Medical Oncology - October 30, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Over-expression of Na+/H+ exchanger 1 and its clinicopathologic significance in hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we first analyzed the NHE1 expression in 100 cases of hepatocellular carcinoma (HCC) and found that NHE1, at both messenger RNA and protein levels, was over-expressed in majority of HCC tissues compared with matched non-cancerous tissue. In addition, the increased expression of NHE1 correlated with tumor size, venous invasion and advanced pTNM stage (P < 0.05). Kaplan–Meier curves demonstrated that patients with increased NHE1 expression were at significantly increased risk for shortened survival time (P < 0.05). This is the first demonstration that the expression level of NHE1...
Source: Medical Oncology - October 30, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Does the sequence of taxane administration affect the outcome of patients with breast cancer in the adjuvant and neoadjuvant settings?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s12032-009-9322-9Authors Ali Alkan, Hacettepe University School of Medicine Department of Internal Medicine Ankara TurkeyUgur Sahin, Hacettepe University School of Medicine Department of Internal Medicine Ankara TurkeyKadri Altundag, Hacettepe University Institute of Oncology Department of Medical Oncology 06100 Sihhiye, Ankara Turkey Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology)
Source: Medical Oncology - October 30, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

MDR1 polymorphism role in patients treated with cetuximab and irinotecan in irinotecan refractory colorectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of the study was to evaluate the influence of the MDR1 C3435T polymorphism on the therapeutic response in 23 patients treated with cetuximab plus irinotecan for irinotecan refractory liver metastatic colorectal cancer considering their KRAS status. Indeed, irinotecan and its active metabolite (SN-38) are both substrates of P-glycoprotein (P-gp) encoded by MDR1. Patients received cetuximab and irinotecan up to progression. The overall survival was 55% at 10 months. Overall, four patients had an undetermined KRAS status and two patients with mutated KRAS were in progression disease. The res...
Source: Medical Oncology - October 27, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Primary small cell carcinoma of the pleura: a case report with immunohistochemical and molecular genetic analyses of KIT and PDGFRA genesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract An extremely rare case of primary small cell carcinoma of the pleura with an emphasis on KIT and platelet-derived growth factor receptor-α (PDGFRA) genes is reported here. A 67-year-old man underwent left testicular orchiectomy because of a testicular tumor. The tumor was immunohistochemically shown to be diffuse large B-cell lymphoma. The patient was treated with chemotherapy and radiation and followed up in our hospital. Eight years after the orchiectomy, the patient (75 years old) developed left pleural tumor and pleural effusion, and a biopsy was performed. The biopsy revealed a medullary m...
Source: Medical Oncology - October 27, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Cell cycle inhibition and apoptosis induced by curcumin in Ewing sarcoma cell line SK-NEP-1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Curcumin is a naturally occurring polyphenolic compound found in the turmeric, which is used as food additive in Indian cooking and as a therapeutic agent in traditional Indian medicine. Curcumin is currently under investigation as a chemotherapeutic and chemopreventive agent in adult cancer models at both pre-clinical and clinical levels. In this preliminary study, we show that curcumin is effective in causing cell cycle arrest, inducing apoptosis, and suppressing colony formation in the Ewing sarcoma cell line SK-NEP-1. Curcumin causes upregulation of cleaved caspase 3 and downregulation of phosph...
Source: Medical Oncology - October 27, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Clinicopathological analysis of primary epithelial appendiceal neoplasmsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to evaluate the clinicopathologic presentation and outcome of patients with appendiceal tumors treated at our institution over a 15-year period. We identified patients with appendiceal tumors diagnosed or treated at our institution from January 1989 through May 2004. Chart review for age, gender, signs and symptoms at diagnosis, and treatment was performed. Review of the pathologic specimens was performed and tumors were classified as DPAM, PMCA I/D, or PMCA. Forty patients were identified (median age 52.5 years; males 38%). The number of patients with DPAM, PMCA I/D, and PMCA was ...
Source: Medical Oncology - October 22, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Intracranial tumor lysis and cerebral edema after administration of intrathecal methotrexate: a case report and discussionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of seizures after intrathecal administration of methotrexate, during the management of diffuse large B-cell lymphoma. There was complete resolution of the CNS lesions after chemotherapy along with the interval development of diffuse cerebral edema. We hypothesize that tumor lysis is the underlying mechanism of this untoward event, resulting in the corresponding clinical presentation. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9338-1Authors Lohith S. Bachegowda, Hahnemann University Hospital/Drexel University College of Medicine Department of Internal Medicine Philade...
Source: Medical Oncology - October 22, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

The effect of peripheral blood values on prognosis of patients with locally advanced gastric cancer before treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract We aimed to investigate the prognostic significance of neutrophil, lymphocyte, platelet, mean platelet value (MPV), platelet-lymphocyte ratio (PLR) and neutrophil–lymphocyte ratio (NLR) in patients with locally advanced gastric cancer (LAGC). One hundred sixty-eight patients with LAGC who had been followed-up between 2004 and 2008 were included in present study. The results of hematological (platelet, lymphocyte, neutrophil and MPV) and biochemical (uric acid and LDH) parameters were evaluated before treatment. NLR was divided into two groups as <2.56 and ≥2.57 and PLR was also divided into t...
Source: Medical Oncology - October 22, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Thrombotic microangiopathy following docetaxel and trastuzumab chemotherapy: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a 47-year-old patient with localised breast cancer who developed thrombotic microangiopathy (HUS/TTP) acutely following concurrent neoadjuvant therapy with trastuzumab and docetaxel. We demonstrate from our case that mild confusion occurring on a background of mild anaemia and thrombocytopenia may sometimes be the only clue to the diagnosis. Clinicians should be aware of the possibility of thrombotic microangiopathy associated with trastuzumab and docetaxel therapy, as early intervention can improve clinical outcome. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9333-6Authors ...
Source: Medical Oncology - October 22, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Tamoxifen and arrhythmiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Tamoxifen is an orally active selective estrogen receptor modulator that is used in the treatment of breast cancer and is currently the world’s largest selling drug for that purpose. However, it has some side effects including hot flashes, menstrual irregularity, vaginal discharges, uterine bleeding, uterine endometrial cancer, hypercoagulability, steatosis hepatis, risk of trombembolism. Long-term data from clinical trials have failed to demonstrate a cardioprotective effect and beneficial effects on serum lipid profiles. Arrhythmia secondary to tamoxifen is very rare. Content Type Journal Art...
Source: Medical Oncology - October 21, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Frequency of TPMT alleles in Indian patients with acute lymphatic leukemia and effect on the dose of 6-mercaptopurineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Functional polymorphisms in the thiopurine methyl transferase (TPMT) gene have been associated with varying levels of enzyme activity and the occurrence of toxicity related to thiopurines. A total of 98 patients (66 pediatric and 32 adults) with precursor B acute lymphoblastic leukemia (Pre-B ALL) were evaluated for TPMT gene polymorphisms. The inability to tolerate 6-mercaptopurine (6-MP) at conventional doses was considered as a surrogate marker of hematologic toxicity. The allele frequency of TPMT*2, *3A, *3B and *3C in the study population was 0.5, 0, 0 and 2.6%, respectively, similar to the fre...
Source: Medical Oncology - October 15, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Infections in acute myeloid leukemia: an analysis of 382 febrile episodesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Neutropenic fever is an important cause of morbidity and mortality during therapy of acute myeloid leukemia (AML). We retrospectively analyzed 382 febrile episodes encountered during induction and consolidation chemotherapy to determine the potential etiology, microbiologic spectrum, response/resistance to antibiotics and outcome. Between May, 2001 and December, 2006, 95 patients with de novo non-M3 AML received remission induction chemotherapy followed by consolidation in those who achieved complete remission. Patients median age was 28 years, ranging from 2 to 61 years, 26 patients were ...
Source: Medical Oncology - October 15, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Recovery of paraneoplastic hypercalcemia by sunitinib treatment for renal cell carcinoma: a case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of paraneoplastic hypercalcemia, resistant to conventional treatment but recovers by sunitinib treatment as the first case in the literature, in a 33-years-old man with metastatic RCC. At the sixth month of follow-up period, in this case, serum calcium level was still in normal ranges. Besides sunitinib is effective in symptom control, it is also helpful in management of paraneoplastic hypercalcemia, a life-threatening entity. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9327-4Authors Halit Karaca, Erciyes University Medical Faculty Departments of Medical Oncology Kays...
Source: Medical Oncology - October 15, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Elevated serum levels of TPS and CYFRA 21-1 predict poor prognosis in advanced non-small-cell lung cancer patients treated with gefitinibEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Serum concentrations of tissue polypeptide-specific antigen (TPS) and Cytokeratin-19-Fragments (CYFRA 21-1) before operation or chemotherapy have been proved to be a useful prognostic tool for patients with NSCLC, but the related data for advanced NSCLC patients treated with gefitinib are limited. We retrospectively reviewed 122 advanced NSCLC patients treated with gefitinib between April 2002 and August 2007. Multiple clinical factors including pretreatment serum levels of TPS and CYFRA 21-1, age, gender, performance status (PS), smoking history, stage, histology, the number of prior chemotherapy a...
Source: Medical Oncology - October 15, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Radiological assessment following thermoradiation therapy for primary pleural synovial sarcoma: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report of an advanced inoperable primary pleural synovial sarcoma is the first to address the use of hyperthermia therapy in combination with chemoradiotherapy for this disease, together with radiological assessment following that therapy. Computed tomography performed after thermoradiation showed a decrease in tumor size and a characteristic unenhanced low-density area in the tumor suggesting that tumor necrosis resulted from the therapy. These image findings were helpful in assessing the tumor response to thermoradiation. We believe that hyperthermia therapy combined with chemoradiotherapy should be regarded as...
Source: Medical Oncology - October 10, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Primary extranodal marginal zone lymphoma of the uvea associated with massive diffuse epibulbar extension and focal infiltration of the optic nerve and meninges, clinically presented as uveitis masquerade syndrome: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a 80-year-old male patient with a 3-year history of chronic recurrent hypertensive (pan) uveitis associated with ocular pain, unresponsive to topical and systemic anti-inflammatory, immunosuppressive, antibiotic/antiviral and antiglaucomatous therapy. Because the eye was not salvageable with conservative treatment, enucleation of blind and painful eye was performed. Findings from histopathological and immunohistochemistry examination of the enucleated eye showed an extranodal marginal zone lymphoma of the uveal tract with massive epibulbar extension and optic nerve and meningeal penetration. During almost ...
Source: Medical Oncology - October 9, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Inhibition of Notch3 enhances sensitivity to gemcitabine in pancreatic cancer through an inactivation of PI3K/Akt-dependent pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we sought to determine the effect of suppressing Notch3 expression on the chemosensitivity to gemcitabine in human pancreatic cancer cell lines BxPC-3 and PANC-1. RNA interference was used to suppress Notch3 expression. Gemcitabine-induced cytotoxicity was determined by MTT. Cell apoptosis was measured by flow cytometry. Caspase 3 activity was assayed using a Caspase Fluorescent Assay Kit. The effect of Notch3-specific siRNA on PI3K/Akt activity was also quantified. Notch3-specific siRNA suppressed Notch3 expression, and furthermore increased gemcitabine-induced, caspase-mediated apoptosis. The suppressi...
Source: Medical Oncology - October 9, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

VEGF −460C>T polymorphism and cancer risk: a meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Vascular endothelial growth factor (VEGF) is a major driver of physiological and pathological angiogenesis and plays important roles in the etiology and metastasis of cancers. The −460C>T polymorphism in VEGF gene region has been implicated in cancer risk and related to VEGF expression. However, published data remain conflicting. To derive a more precise estimation, a meta-analysis of 5,863 cases and 5,276 controls from 14 published case–control studies was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association. VEGF −460T represented a risk...
Source: Medical Oncology - October 9, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Loss of p16INK4, alone and with overexpression of osteopontin, correlates with survival of patients with spinal metastasis from hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The survival of patients with hepatocellular carcinoma (HCC) has been improved with various diagnostic tools and treatment modalities. Consequently, spinal metastases from HCC are diagnosed more frequently. We investigated the clinical biomarkers of HCC patients presenting with spinal metastasis. Between January 2001 and December 2007, we recruited 30 consecutive HCC patients presenting with spinal metastasis. Their tissue samples were collected and analyzed by immunohistochemistry in a tissue microarray. A total of 16 proteins were assessed in the tissue microarray; we found that expression of...
Source: Medical Oncology - October 8, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

High-resolution melting analysis of ADAMTS18 methylation levels in gastric, colorectal and pancreatic cancersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A disintegrin and metalloprotease with trombospondin motifs (ADAMTS) is a family of proteins characterized by the presence of a metalloproteinase domain linked to a variety of specialized ancillary domains. ADAMTS18 is a putative tumor suppressive gene related to nasopharyngeal carcinoma. We used high-resolution melting (HRM) analysis to detect the methylation levels of ADAMTS18 gene in 100 gastric cancers, 100 colorectal cancers, 70 pancreatic cancers, and equal number of adjacent normal tissues. The frequency of ADAMTS18 methylation in all three types of cancers was significantly higher than that ...
Source: Medical Oncology - October 6, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

A novel role of cyclinD1 and p16 in clinical pathology and prognosis of childhood medulloblastomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Medulloblastoma (MB) is the most common malignant brain tumor in children. CyclinD1 is strongly implicated in the control of G1 progression and the phosphorylation of the retinoblastoma protein; p16 could specifically interact with cyclinD1 to inhibit the activity of cyclin-dependent kinase 4. The purpose of this study was to investigate whether quantitative assessment of cyclinD1 and p16 may predict the clinical prognosis in MB. We analyzed the expression of cyclinD1 and p16 antigens in a series of 42 MB with various grades and pathological types by immunohistochemical analysis on paraffin-embedded...
Source: Medical Oncology - October 6, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Evaluation of burnout syndrome in oncology employeesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Burnout is an important occupational problem for health care workers. We aimed to assess the burnout levels among oncology employees and to evaluate the sociodemographic and occupational factors contributing to burnout levels. The Maslach Burnout Inventory, which is designed to measure the three stages of burnout-emotional exhaustion (EE), depersonalization (DP), and personal accomplishment (PA), was used. The study sample consisted of 90 participants with a median age of 34 (range 23–56). The mean levels of burnout in EE, DP and PA stages were 23.80 ± 10.98, 5.21 ± 4.99, and...
Source: Medical Oncology - September 30, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Long-term outcome of mesna, ifosfamide, mitoxantrone, etoposide (MINE) regimen as a consolidation in patients with aggressive non-Hodgkin lymphoma responding to CHOPEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract In aggressive non-Hodgkin lymphoma (NHL), CHOP (cyclophosphamide, vincristine, doxorubicin, prednisolone) regimen has been standard for decades, and rituximab has increased response rates and survival in CD20 positive patients, recently. The aim of this prospective trial was to evaluate the long-term efficacy and toxicity of MINE as a consolidation treatment in aggressive NHL patients who had achieved CR or unproven CR after six cycles of CHOP in the first line setting. The primary end-point was disease-free-survival (DFS). Thirty-eight patients were enrolled between February 1992 and May 2000. All ...
Source: Medical Oncology - September 29, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Actual status of adjuvant chemotherapy for non-small-cell lung cancer at one Japanese cancer center: the need for increased cooperation between medical oncologists and surgeonsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study revealed that there were considerable differences in whether patients consented to adjuvant chemotherapy depending on the medical oncologists that they were referred to, and suggested possible differences in the judgment of the patients’ suitability for adjuvant chemotherapy among surgeons. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9309-6Authors Takehito Shukuya, Shizuoka Cancer Center Division of Thoracic Oncology 1007 Shimonagakubo, Nagaizumi-cho, Suntou-gun Shizuoka 411-8777 JapanToshiaki Takahashi, Shizuoka Cancer Center Division of Thoracic Oncology 1007 Shimonagakub...
Source: Medical Oncology - September 25, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Serum levels of CEA and CA 15-3 in triple-negative breast cancer at the time of diagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s12032-009-9310-0Authors Didem S. Dede, Hacettepe University Institute of Oncology Department of Medical Oncology Sihhiye 06100 Ankara TurkeyCagatay Arslan, Hacettepe University Institute of Oncology Department of Medical Oncology Sihhiye 06100 Ankara TurkeyKadri Altundag, Hacettepe University Institute of Oncology Department of Medical Oncology Sihhiye 06100 Ankara Turkey Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology)
Source: Medical Oncology - September 24, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Myoepithilial carcinoma of the retromolar area in a young female. A rare case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of a 34-year-old woman with myoepithelial carcinoma of the retromolar area. Myoepithilial carcinoma is a rare tumor of small salivary glands most usually located in the parotid gland. The major differential diagnosis of myoepithelioma is from pleomorphic adenoma. Little is known about the clinical and biological behavior and the prognosis of myoepithelial carcinoma and there is no consensus for its treatment. It is considered a low-grade malignancy; it sometimes shows aggressive behavior and may locally recur. Our patient was treated successfully with wide-local resection and remained free of disease ...
Source: Medical Oncology - September 22, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

A case–control study of reproductive factors associated with subtypes of breast cancer in Northeast ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Based on the expression of estrogen receptor (ER), progesterone receptor (PR) and HER2/neu (HER2), breast cancer is classified into several subtypes: luminal A (ER+ and/or PR+, HER2−), luminal B (ER+ and/or PR+, HER2+), HER2-overexpressing (ER−, PR−, and HER2+) and triple-negative (ER−, PR−, and HER2−). The aim of this case–control study is to determine reproductive factors associated with breast cancer subtypes in Chinese women. A total of 1,417 patients diagnosed with breast cancer in the First Affiliated Hospital, China Medical University, Shenyang, China between 2001 and 2009 and 1...
Source: Medical Oncology - September 22, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Effects of Lewis Y antigen on the gene expression of multiple drug resistance-associated proteins in human ovarian cancer RMG-I-H cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, Lewis Y antigen is closely associated with regulating the gene expression of multiple drug resistance-associated proteins. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9317-6Authors Song Gao, Shengjing Hospital Affiliated to China Medical University Department of Obstetrics and Gynecology 110004 Shenyang People’s Republic of ChinaQing Liu, Shengjing Hospital Affiliated to China Medical University Department of Obstetrics and Gynecology 110004 Shenyang People’s Republic of ChinaXinyan Wang, Shengjing Hospital Affiliated to China Medical University Department of Obstetric...
Source: Medical Oncology - September 22, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

p53 codon 72 polymorphism and risk of cervical carcinoma in Moroccan womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the polymorphism was examined by both allele-specific PCR and RFLP analysis in 113 patients with cervical cancer and in 100 healthy controls. There was no statistical difference in the subtype distribution between the cervix cancer and the control groups. There was no significant association between genotype distribution of the p53 codon 72 polymorphism and HPV infection. Thus, polymorphism of the p53 itself as well as in combination with HPV infection may not be a genetic risk for cervical cancer and therefore much attention should be paid to other risk factors such as sexual behavior and smoking. C...
Source: Medical Oncology - September 22, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Quality of life and depression among metastatic breast cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Depression is seen in many cancer patients. It is common in the general population and in adults and children with cancer and frequently coexists with anxiety and pain. The pilot study evaluated the level of the global quality of life (QoL) and the incidence and the relevance of the depression among metastatic breast cancer patients in a programme of palliative cancer care. The study is prospective and cross-sectional. Dates were obtained during year 2008 among 41 patients. The mean age of all 41 subjects was 58 years old (aged 41–80 years old). The Czech version of Zung self-rating depr...
Source: Medical Oncology - September 22, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Exacerbation of chronic idiopathic thrombocytopenic purpura following reactivation of an occult hepatitis BEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of autoimmune thrombocytopenia associated with acute reverse seroconversion of hepatitis B in a patient who was initially hepatitis B virus surface antigen negative and hepatitis B virus surface antibody positive. The search for occult HBV infection before immunosuppressive therapy and monitoring for reactivation is today diagnostic standard and several reports have been presented in literature about HBV reactivation following immunosuppressive therapy. In our patient, reactivation of dormant HBV happened prior to any immunosuppressive therapy. The case we report offers the occasion to emphasize the i...
Source: Medical Oncology - September 22, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Spontaneous pyopneumothorax in patients treated with mTOR inhibitors for subpleural pulmonary metastasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report extends the available experience of the pulmonary side effects of these novel targeted therapies. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9311-zAuthors Sylvain Ladoire, Centre Georges François Leclerc Department of Medical Oncology 1 rue du Professeur Marion 21000 Dijon FranceCaroline Beynat, Centre Hospitalier Universitaire Department of Pulmonary, Critical Care and Sleep Medicine Dijon FrancePierre Diaz, Centre Hospitalier Universitaire Department of Pulmonary, Critical Care and Sleep Medicine Dijon FranceBruno Coudert, Centre Georges François Leclerc Department of Me...
Source: Medical Oncology - September 19, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

A critical role of surgery in the treatment for paraneoplastic pemphigus caused by localized Castleman’s diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Paraneoplastic pemphigus (PNP) is an autoimmune mucocutaneous disease associated with lymphoproliferative tumors, and sometimes with a very rare tumor, Castleman’s disease (CD). PNP can present as a variety of dermatological diseases, and so far, only limited studies of PNP caused by CD have been reported, resulting in its higher possibility of misdiagnosis. Because of the variability of clinical presentation of PNP caused by CD, selection of the appropriate therapeutic approach remains unclear. To investigate the efficacy of surgery to patients with PNP caused by localized CD, the clinical, labor...
Source: Medical Oncology - September 18, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals