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Identification of Mesenchymal Stromal Cells in Human Lung Parenchyma Capable of Differentiating into Aquaporin 5-Expressing CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Without good therapies for end-stage lung disease, is there a need for alternative treatments like stem cell-based therapeutic approaches? Laboratory Investigation (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - November 13, 2009 Category: Pathology Tags: Pathology & Lab Medicine Source Type: info

Genetic Polymorphisms Associated With Acute Lung InjuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors discuss methods for identification of candidate acute lung injury genes using a number of model systems Pharmacogenomics (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - November 12, 2009 Category: Pathology Tags: Pathology & Lab Medicine Source Type: info

Carboxymethyl-Lysine Levels Linked to Mortality in Older AdultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Increased plasma carboxymethyl-lysine (CML), an advanced glycation end product (AGE), is associated with higher mortality from all causes and from cardiovascular disease in older adults, new research shows. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - November 9, 2009 Category: Pathology Tags: Internal Medicine Source Type: info

New Report Spotlights Breast Tumor "Evolution"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As cancer progresses there can be "significant evolution" in malignant tissue, new research shows. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - October 8, 2009 Category: Pathology Tags: Pathology & Lab Medicine Source Type: info

Adenovirus-P53 Gene Therapy Feasible for Squamous Cell CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
INGN 201 (adenovirus-p53) gene therapy shows promise for advanced, resectable squamous cell carcinoma of the head and neck, according to a report from the Southwest Oncology Group (SWOG). Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - October 2, 2009 Category: Pathology Tags: Hematology-Oncology Source Type: info

A Single-Nucleotide Polymorphism in the MDR1 Gene as a Predictor of Response to Neoadjuvant Chemotherapy in Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Investigators examined the frequency of SNP in exon 26 of the MDR1 gene in breast cancer and its role in predicting response to neoadjuvant chemotherapy in breast cancer. Clinical Breast Cancer (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - September 30, 2009 Category: Pathology Tags: Hematology-Oncology Source Type: info

Toll Like Receptor Four (tlrfour) Polymorphisms in Tunisian Patients With Crohn's Disease: Genotype-Phenotype CorrelationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Investigators examined whether the TLRfour gene is associated with Crohn's disease among the Tunisian population and whether there is a correlation with clinical manifestation of the disease. BMC Gastroenterology (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - September 30, 2009 Category: Pathology Tags: Gastroenterology Source Type: info

A Novel Five-Antibody Immunohistochemical Test for Subclassification of Lung CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Need for a uniform method of classifying lung carcinomas is growing. Could a 5-antibody test have immediate function in the clinic to help pathologists distinguish lung carcinoma histological types? Modern Pathology (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - September 30, 2009 Category: Pathology Tags: Pathology & Lab Medicine Source Type: info

Genetic Influences on Disease Severity in Rheumatoid ArthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dr. Ali Torkamani comments on a recent study in Arthritis & Rheumatism identifying an association between a unique genetic variant and the rate of joint destruction in rheumatoid arthritis. Medscape Genomic Medicine (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - September 24, 2009 Category: Pathology Tags: Pathology & Lab Medicine Source Type: info

Comparative Effectiveness Research and the Medical Home -- Made for Each Other?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Does comparative effectiveness research mean the end of individualized medicine, or is it an ideal partner with the medical home for reforming primary care? Medscape Med Students (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - September 23, 2009 Category: Pathology Tags: Internal Medicine Source Type: info

New Microbe-Derived Drug Shows Selective Activity Against C. DifficileEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A newly discovered drug, derived from a microbial antibiotic, is a potent and selective inhibitor of Clostridium difficile, according to study findings presented this week at the Interscience Conference on Antimicrobial Agents and Chemotherapy in San Francisco. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - September 21, 2009 Category: Pathology Tags: Infectious Diseases Source Type: info

CDC’s Ambitious Goal for Colorectal Cancer ScreeningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Centers for Disease Control and Prevention hopes to have 80% of the population 50 years and older screened for colorectal cancer by the end of a 5-year program in many states. Medscape Medical News (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - September 15, 2009 Category: Pathology Tags: Hematology-Oncology Source Type: info

Immediate vs Delayed Intervention Not Superior in Reducing MI in NSTE-ACSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In patients with acute coronary syndromes without ST-segment elevation, no significant difference exists between immediate vs delayed intervention in reducing myocardial infarction. Medscape Medical News (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - September 14, 2009 Category: Pathology Tags: Cardiology Source Type: info

Unenhanced CT May Assist in Diagnosis of Children With Flank PainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In a retrospective study, unenhanced computed tomography played an important role in evaluating children with flank pain; approximately 15% of children with urolithiasis did not have hematuria. Medscape Medical News (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - September 14, 2009 Category: Pathology Tags: Pediatrics Source Type: info

High Placental Weight Relative to Birth Weight May Increase Cardiovascular MortalityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A high ratio of placenta-to-birth-weight is associated with an increased risk of death from cardiovascular diseases in adulthood, according to a large prospective study. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - September 4, 2009 Category: Pathology Tags: Cardiology Source Type: info

Seven-valent Pneumococcal Conjugate Vaccines for Developing CountriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pneumococcal disease kills more children than any other illness, but several developing countries still fail to recognize invasive pneumococcal disease as a major problem. Expert Review of Vaccines (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - September 2, 2009 Category: Pathology Tags: Infectious Diseases Source Type: info

Kidney Disease: Improving Global OutcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Monitoring calcium, phosphorus, PTH and alkaline phosphatase and basing decisions on trends is the best approach to managing mineral and bone disorder in patients with CKD, says a new guideline. The National Kidney Foundation (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - August 18, 2009 Category: Pathology Tags: Nephrology Source Type: info

Kidney Disease: Improving Global Outcomes (KDIGO) Releases Guideline on Mineral and Bone Disorder of Chronic Kidney DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Monitoring calcium, phosphorus, PTH and alkaline phosphatase and basing decisions on trends is the best approach to managing mineral and bone disorder in patients with CKD, says a new guideline. The National Kidney Foundation (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - August 14, 2009 Category: Pathology Tags: Nephrology Source Type: info

Safety of Bevacizumab in Advanced Ovarian and Müllerian Cancers: A ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This review article discusses the safety of bevacizumab in advanced recurrent ovarian, fallopian, and peritoneal disease. Clinical Ovarian Cancer (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - August 11, 2009 Category: Pathology Tags: Hematology-Oncology Source Type: info

Differential Expression of SOX2 and SOX17 in Testicular Germ Cell TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Testicular germ cell tumors are examined for SOX2 and SOX17 expression patterns. American Journal of Clinical Pathology (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - August 7, 2009 Category: Pathology Tags: Pathology & Lab Medicine Source Type: info

Diet Restriction May Not Increase LifespanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New research with fruits flies suggests that, contrary to previous reports, diet restriction may not increase lifespan. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - July 21, 2009 Category: Pathology Tags: Pathology & Lab Medicine Source Type: info

Upregulated MicroRNA-21 Linked to Lung Cancer in NonsmokersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New research suggests that increased expression of microRNA (MiR)-21 plays an important role in the pathogenesis of lung cancer in never smokers. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - July 15, 2009 Category: Pathology Tags: Pathology & Lab Medicine Source Type: info

Class Effect of Erythropoietin Therapy on Hemoglobin A1c in a Patient With DiabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
How do erythropoietin analogs affect hemoglobin A1c in patients with diabetes? Pharmacotherapy (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - July 9, 2009 Category: Pathology Tags: Pharmacist Source Type: info

GM-CSF Improves Peripheral Arterial DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bone marrow mobilization with granulocyte macrophage colony-stimulating factor (GM-CSF) improves outcomes in patients with peripheral arterial disease, according to a report in the July American Heart Journal. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - July 8, 2009 Category: Pathology Tags: Cardiology Source Type: info

Public Interest and Expectations Concerning Commercial Genotyping and Genetic Risk AssessmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
What are the public attitudes towards genetic testing for common diseases and the population's desire to estimate their own genetic risks? Personalized Medicine (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - July 7, 2009 Category: Pathology Tags: Med Students Source Type: info

The Genetic Information Nondiscrimination Act (GINA): What it Means for Your Patients and FamiliesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
What is the scope of this new law? Are there limitations? How can nurses help facilitate compliance? OJIN: The Online Journal of Issues in Nursing (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - July 6, 2009 Category: Pathology Tags: Nursing Source Type: info

Low Levels of Low-Density Lipoprotein Cholesterol and Blood Pressure and Progression of Coronary AtherosclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study provides important mechanistic information about the effects of LDL-C and SBP on cardiovascular disease and supports the need for intensive management of global risk in patients with CAD. Journal of the American College of Cardiology (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - June 30, 2009 Category: Pathology Tags: Cardiology Source Type: info

Contrast-Induced Nephropathy May Be Linked to Long-Term Adverse EventsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
After adjustment for baseline comorbidities and risk factors, the incidence rate ratio for adverse events was twice as high in those with CIN defined stringently. Medscape Medical News (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - June 26, 2009 Category: Pathology Tags: Nephrology Source Type: info

Prostatic Intraepithelial Neoplasia May Predict CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Almost half of men whose extended core needle prostatic biopsies reveal isolated high-grade prostatic intraepithelial neoplasia (HGPIN) subsequently develop prostate cancer. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - June 22, 2009 Category: Pathology Tags: Hematology-Oncology Source Type: info

Blood Test May Determine Short-Term Risk of Death in Idiopathic Pulmonary FibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Serum surfactant protein A, a protein that is generated in the lungs and finds its way into the peripheral circulation when the lung is injured, is one of the strongest independent predictors of early mortality in the first year after diagnosis of idiopathic pulmonary fibrosis (IPF). Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - June 22, 2009 Category: Pathology Tags: Pulmonary Medicine Source Type: info

Cyclophilin Inhibitor Shows Promise in Mouse Model of Muscular DystrophyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The selective cyclophilin inhibitor Debio 025 normalizes mitochondrial function, muscle apoptosis and ultrastructural defects in a mouse model of muscular dystrophy caused by defects of collagen VI. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - June 19, 2009 Category: Pathology Tags: Neurology & Neurosurgery Source Type: info

Society of Nuclear Medicine Issues Medical Isotope CommuniquEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - June 16, 2009 Category: Pathology Tags: Pathology & Lab Medicine Source Type: info

Several Factors Linked to Increased Risk for Mortality From Vaginal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A population-based study shows that stage, tumor size, histologic features, and treatment modality significantly affect the risk for mortality from vaginal cancer. Medscape Medical News (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - June 9, 2009 Category: Pathology Tags: Ob/Gyn & Women ' s Health Source Type: info

Canada Medical Reactor Shutdown May Be ExtendedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An aging Canadian nuclear reactor that makes a third of the world's medical isotopes may have to be shut down for longer than the three months initially forecast, the operator said on Thursday. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - June 8, 2009 Category: Pathology Tags: Business of Medicine Source Type: info

New Gene Variant Linked to AutismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
US researchers have identified a variant in the CACNA1G gene that confers susceptibility to autism, especially in boys. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - June 8, 2009 Category: Pathology Tags: Psychiatry Source Type: info

Gaucher's Disease Mutation Increases Risk of Parkinson's and Lewy Body DementiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mutations in the glucocerebrosidase (GBA) gene that cause Gaucher's disease are also associated with an increased risk of Parkinson's disease and dementia with Lewy bodies, according to two reports in the May issue of the Archives of Neurology. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - May 27, 2009 Category: Pathology Tags: Neurology & Neurosurgery Source Type: info

Caveolin-1 Is the Strongest Prognostic Marker for Breast Cancer to DateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers report in the June issue of The American Journal of Pathology that a loss of stromal caveolin-1 expression is "the single strongest predictor of breast cancer patient outcome." Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - May 27, 2009 Category: Pathology Tags: Pathology & Lab Medicine Source Type: info

ASCO 2009: Immunotherapy Prolongs Survival in High-risk Pediatric NeuroblastomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An experimental antibody product, manufactured at the National Cancer Institute, has shown a 20% increase in survival in children with high-risk neuroblastoma. Medscape Medical News (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - May 19, 2009 Category: Pathology Tags: Hematology-Oncology Source Type: info

Novel Blood Biomarker Improves Accuracy of Lung Cancer Prediction ModelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Using a new approach to detect tumor-associated plasma proteins, Canadian researchers have discovered a novel biomarker that may improve the diagnosis of lung cancer in the preclinical stage. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - May 14, 2009 Category: Pathology Tags: Hematology-Oncology Source Type: info

Melamine Nephrotoxicity: An Emerging Epidemic in an Era of GlobalizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephrolithiasis and acute kidney injury have recently been linked to melamine contaminated infant formula in China. Global impact and potential mechanisms of melamine nephrotoxicity are discussed. Kidney International (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - May 13, 2009 Category: Pathology Tags: Nephrology Source Type: info

Potassium Channel Gene Mutations Cause EAST SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epilepsy, ataxia, sensorineural hearing loss, and tubulopathy cooccur in patients homozygous for a mutation in KCNJ10. Medscape Medical News (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - May 6, 2009 Category: Pathology Tags: Neurology & Neurosurgery Source Type: info

Gene Therapy Promising in Muscular DystrophyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The results of a phase I/II study of patients with limb-girdle muscular dystrophy (LGMD2D), which is associated with a faulty alpha-sarcoglycan gene (SGCA), indicate that gene replacement therapy may be successful, researchers report in an April 15th on-line issue of the Annals of Neurology. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - May 5, 2009 Category: Pathology Tags: Neurology & Neurosurgery Source Type: info

Gene Test Predicts Survival With MesotheliomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 4-gene expression ratio test accurately predicts survival in patients with malignant pleural mesothelioma, according to a report in the May 6th Journal of the National Cancer Institute. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - May 5, 2009 Category: Pathology Tags: Hematology-Oncology Source Type: info

Causes of Late Graft Loss in Kidney TransplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two studies look at why long-term graft survival rates have not improved despite advances in immunosuppression. Medscape Transplantation (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - April 24, 2009 Category: Pathology Tags: Transplantation Source Type: info

Molecular Profiling of Tumors Improves Cancer TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Identifying mutations in individual tumors allows for personalized treatment with drugs that are more likely to be effective. Medscape Medical News (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - April 21, 2009 Category: Pathology Tags: Hematology-Oncology Source Type: info

Measuring Circulating Tumor Cells Is Clinically Useful, New Technique Promises to Be FasterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Measuring circulating tumor cells in the blood of cancer patients has already proven to be clinically useful, and a new device under development could make the process faster. Medscape Medical News (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - April 21, 2009 Category: Pathology Tags: Hematology-Oncology Source Type: info

Genetic Factors Tied to Patent Ductus ArteriosusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Certain single-nucleotide polymorphisms (SNPs) are markers for persistent patency of the ductus arteriosus (PDA) in preterm infants, researchers report in the April issue of Pediatrics. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - April 17, 2009 Category: Pathology Tags: Pediatrics Source Type: info

Quest to Pay $302 Mln to Settle Test Kit ChargesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Quest Diagnostics agreed to pay $302 million to settle charges that a subsidiary knowingly sold test kits that produced inaccurate results, the U.S. Department of Justice said on Wednesday. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - April 17, 2009 Category: Pathology Tags: Pathology & Lab Medicine Source Type: info

Pluripotent Stem Cells Derive From Adult Human TestesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
With a relatively simple process, pluripotent stem cells can be derived from adult human testis tissue, according to a report issued online March 22 by the journal Stem Cells and Development. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - April 15, 2009 Category: Pathology Tags: Pathology & Lab Medicine Source Type: info

Clonal Mast Cell Disorders Common in Patients Who Have Bee/Wasp Sting ReactionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A large percentage of patients who have systemic reactions to Hymenoptera stings and increased serum levels of the mast cell product tryptase can be shown to have clonal mast cell disorders, according to a report in the March issue of the Journal of Allergy and Clinical Immunology. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - April 15, 2009 Category: Pathology Tags: Allergy/Clinical Immunology Source Type: info