Interplay of CD36, autophagy, and lipid metabolism: insights into cancer progression
CD36, a scavenger receptor B2 that is dynamically distributed between cell membranes and organelle membranes, plays a crucial role in regulating lipid metabolism. Abnormal CD36 activity has been linked to a range of metabolic disorders, such as obesity, nonalcoholic fatty liver disease, insulin resistance and cardiovascular disease. CD36 undergoes various modifications, including palmitoylation, glycosylation, and ubiquitination, which greatly affect its binding affinity to various ligands, thereby triggering and influencing various biological effects. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 26, 2024 Category: Biomedical Science Authors: Yuxuan Yang, Xiaokun Liu, Di Yang, Lianhui Li, Sheng Li, Sen Lu, Ning Li Source Type: research

Resmetirom, the first approved drug for the management of metabolic dysfunction-associated steatohepatitis: Trials, opportunities, and challenges
Over the past decade, there have been several guideline updates for the diagnosis and management of non-alcoholic fatty liver disease (NAFLD), which is the most common chronic liver disease affecting approximately one-third of the world's population [1 –3]. These changes were necessitated by our evolving understanding of the disease, the name of which has also recently been changed from “NAFLD”, resulting from a lack of mechanistic understanding to metabolic dysfunction-associated steatotic liver disease (MASLD), and from non-alcoholic steat ohepatitis (NASH) to metabolic dysfunction-associated steatohepatitis (MASH)...
Source: Metabolism - Clinical and Experimental - March 18, 2024 Category: Biomedical Science Authors: Michail Kokkorakis, Chrysoula Boutari, Michael A. Hill, Vasilios Kotsis, Rohit Loomba, Arun J. Sanyal, Christos S. Mantzoros Tags: Editorial Source Type: research

Metabolic plasticity and obesity-associated changes in diurnal postexercise metabolism in mice
Circadian disruption is widespread and increases the risk of obesity. Timing of therapeutic interventions may promote coherent and efficient gating of metabolic processes and restore energy homeostasis. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 10, 2024 Category: Biomedical Science Authors: Logan A. Pendergrast, Stephen P. Ashcroft, Amy M. Ehrlich, Jonas T. Treebak, Anna Krook, Lucile Dollet, Juleen R. Zierath Source Type: research

The role and mechanisms of non-coding RNAs in diabetic peripheral neuropathy
Diabetic peripheral neuropathy (DPN) is a complication of diabetes with a high rate of disability. However, current clinical treatments for DPN are suboptimal. Non-coding RNAs (ncRNAs) are a type of RNAs that are not translated into proteins. NcRNAs perform functions that regulate epigenetic modifications, transcriptional or post-transcriptional regulators of proteins, and thus participate in the physiological and pathological processes of the body. NcRNAs play a role in the progress of DPN by affecting the processes of inflammation, oxidative stress, cellular autophagy or apoptosis. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 8, 2024 Category: Biomedical Science Authors: Yiqian He, Ling Qu Tags: Review Source Type: research

Interleukin-6 classic and trans-signaling utilize glucose metabolism reprogramming to achieve anti- or pro-inflammatory effects
Interleukin (IL)-6 has anti- and pro-inflammatory functions, controlled by IL-6 classic and trans-signaling, respectively. Differences in the downstream signaling mechanism between IL-6 classic and trans-signaling have not been identified. Here, we report that IL-6 activates glycolysis to regulate the inflammatory response. IL-6 regulates glucose metabolism by forming a complex containing signal-transducing activators of transcription 3 (STAT3), hexokinase 2 (HK2), and voltage-dependent anion channel 1 (VDAC1). (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 2, 2024 Category: Biomedical Science Authors: Shilei Xu, Ke-Qiong Deng, Chengbo Lu, Xin Fu, Qingmei Zhu, Shiqi Wan, Lin Zhang, Yu Huang, Longyu Nie, Huanhuan Cai, Qiming Wang, Hao Zeng, Yufeng Zhang, Fubing Wang, Hong Ren, Yu Chen, Huan Yan, Ke Xu, Li Zhou, Mengji Lu, Ying Zhu, Shi Liu, Zhibing Lu Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 1, 2024 Category: Biomedical Science Source Type: research

Endothelial cell serum and glucocorticoid regulated kinase 1 (SGK1) mediates vascular stiffening
This study therefore aimed to explore the role of EC-serum and glucocorticoid regulated kinase 1 (SGK1), as a reported regulator of sodium channels, in EC and arterial stiffening. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 28, 2024 Category: Biomedical Science Authors: Liping Zhang, Zhe Sun, Yan Yang, Austin Mack, Mackenna Rodgers, Annayya Aroor, Guanghong Jia, James R. Sowers, Michael A. Hill Source Type: research

Perturbed liver gene zonation in a mouse model of non-alcoholic steatohepatitis
Liver zonation characterizes the separation of metabolic pathways along the lobules and is required for optimal hepatic function. Wnt signaling is a master regulator of spatial liver zonation. A perivenous-periportal Wnt activity gradient orchestrates metabolic zonation by activating gene expression in perivenous hepatocytes, while suppressing gene expression in their periportal counterparts. However, the understanding as to the liver gene zonation and zonation regulators in diseases is limited. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 27, 2024 Category: Biomedical Science Authors: Ye Zhou, Yuanqi Zhao, Marisa Carbonaro, Helen Chen, Mary Germino, Christina Adler, Min Ni, Yuan O. Zhu, Sun Y. Kim, Judith Altarejos, Zhe Li, Michael E. Burczynski, David J. Glass, Mark W. Sleeman, Ann-Hwee Lee, Gabor Halasz, Xiping Cheng Tags: Brief Report Source Type: research

Nonlinear relationship between high-density lipoprotein cholesterol and cardiovascular disease: an observational and Mendelian randomization analysis
Clinical trials and Mendelian randomization (MR) studies reported null effects of high-density lipoprotein cholesterol (HDLC) on risk of cardiovascular disease (CVD), which might have overlooked a nonlinear causal association. We aimed to investigate the dose-response relationship between circulating HDL-C concentrations and CVD in observational and MR frameworks. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 16, 2024 Category: Biomedical Science Authors: Jun-Xiang Chen, Yue Li, Yan-Bo Zhang, Yi Wang, Yan-Feng Zhou, Tingting Geng, Gang Liu, An Pan, Yun-Fei Liao Source Type: research

Ketones provide an extra source of fuel for the failing heart without impairing glucose oxidation
Cardiac glucose oxidation is decreased in heart failure with reduced ejection fraction (HFrEF), contributing to a decrease in myocardial ATP production. In contrast, circulating ketones and cardiac ketone oxidation are increased in HFrEF. Since ketones compete with glucose as a fuel source, we aimed to determine whether increasing ketone concentration both chronically with the SGLT2 inhibitor, dapagliflozin, or acutely in the perfusate has detrimental effects on cardiac glucose oxidation in HFrEF, and what effect this has on cardiac ATP production. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 16, 2024 Category: Biomedical Science Authors: Simran Pherwani, David Connolly, Qiuyu Sun, Qutuba G. Karwi, Michael Carr, Kim L. Ho, Cory S. Wagg, Liyan Zhang, Jody Levasseur, Heidi Silver, Jason R.B. Dyck, Gary D. Lopaschuk Source Type: research

Are we underestimating the potential of neuroactive drugs to augment neuromotor function in sarcopenia?
Sarcopenia is a skeletal muscle disease characterised by exacerbated loss of muscle mass, strength, and/or impaired function with aging and/or disease [2 –7]. Historically, the term “sarcopenia” stems from the Greek words ‘sarx’, for ‘flesh’, and ‘penia’, for ‘loss’, and thus was used to describe age-related loss of muscle mass [8,9]. However, growing recognition that low muscle strength and/or impaired physical function are ind ependent (and often better) predictors of mobility limitations, falls, fractures, and many other health outcomes than muscle mass alone has led to the current multi-dimensiona...
Source: Metabolism - Clinical and Experimental - February 14, 2024 Category: Biomedical Science Authors: Lucas B.R. Orssatto, Jacob R. Thorstensen, David Scott, Robin M. Daly Tags: Editorial Source Type: research

Mortality risk in patients with obesity and COVID-19 infection: a systematic review and meta-analysis
Obesity is a risk factor for severe respiratory diseases, including COVID-19 infection. Meta-analyses on mortality risk were inconsistent.We systematically searched 3 databases (Medline, Embase, CINAHL) and assessed the quality of studies using the Newcastle-Ottawa tool (CRD42020220140).We included 200 studies from US and Europe, with a mean age of participants 41.8 –78.2 years, and a variable prevalence of metabolic co-morbidities of 20–80 %. Exceptionally, one third of the studies had a low prevalence of obesity of (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 12, 2024 Category: Biomedical Science Authors: Haber Rachelle, Ghezzawi Malak, Puzantian Houry, Haber Marc, Saad Sacha, Ghandour Yara, El Bachour Joseph, Yazbeck Anthony, Hassanieh Ghinwa, Mehdi Celine, Ismail Dima, Abi-Kharma Elias, El-Zein Ola, Khamis Assem, Chakhtoura Marlene, Mantzoros Christos Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 4, 2024 Category: Biomedical Science Source Type: research

Corrigendum to “Cooperative STAT3-NFkB signaling modulates mitochondrial dysfunction and metabolic profiling in hepatocellular carcinoma” [Metabolism, Volume 152, March 2024, 155771]
The authors regret that Fig. 2 within this article holds errors. Please find the corrected version of the figure below. This amends both the labelling, and alignment - as well as the removal of SG (secretory granules) and replacement of LD (Lipid droplets) within fig. (B) DEN. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 2, 2024 Category: Biomedical Science Authors: Sharmeen Ishteyaque, Gurvinder Singh, Karan Singh Yadav, Smriti Verma, Rakesh Kumar Sharma, Sumati Sen, Anurag Kumar Srivastav, Kalyan Mitr, Amit Lahiri, Dnyaneshwar U. Bawankule, Srikanta Kumar Rath, Dinesh Kumar, Madhav Nilakanth Mugale Tags: Corrigendum Source Type: research

Autophagy and the unfolded protein response shape the non-alcoholic fatty liver landscape: decoding the labyrinth
The incidence of nonalcoholic fatty liver disease (NAFLD) is on the rise, mirroring a global surge in diabetes and metabolic syndrome, as its major leading causes. NAFLD represents a spectrum of liver disorders, ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), which can potentially progress to cirrhosis and hepatocellular carcinoma (HCC). Mechanistically, we know the unfolded protein response (UPR) as a protective cellular mechanism, being triggered under circumstances of endoplasmic reticulum (ER) stress. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 1, 2024 Category: Biomedical Science Authors: Zahra Dashti, Zeynab Yousefi, Pouria Kiani, Motahareh Taghizadeh, Mohammad Hasan Maleki, Mohammad Borji, Omid Vakili, Sayed Mohammad Shafiee Source Type: research