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Source: Metabolism - Clinical and Experimental - November 13, 2009 Category: Biomedical Science Tags: Frontmatter Source Type: journals

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Source: Metabolism - Clinical and Experimental - November 13, 2009 Category: Biomedical Science Tags: Frontmatter Source Type: journals

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Source: Metabolism - Clinical and Experimental - November 13, 2009 Category: Biomedical Science Tags: Frontmatter Source Type: journals

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Source: Metabolism - Clinical and Experimental - November 13, 2009 Category: Biomedical Science Source Type: journals

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Source: Metabolism - Clinical and Experimental - October 19, 2009 Category: Biomedical Science Tags: Frontmatter Source Type: journals

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Source: Metabolism - Clinical and Experimental - October 19, 2009 Category: Biomedical Science Tags: Frontmatter Source Type: journals

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Source: Metabolism - Clinical and Experimental - October 19, 2009 Category: Biomedical Science Tags: Frontmatter Source Type: journals

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Source: Metabolism - Clinical and Experimental - October 19, 2009 Category: Biomedical Science Source Type: journals

Clinical characteristics and efficacy of pioglitazone in a Japanese diabetic patient with an unusual type of familial partial lipodystrophyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report describes a 46-year-old Japanese diabetic woman with an unusual type of familial partial lipodystrophy. She has marked loss of subcutaneous fat in her lower limbs and buttocks, with sparing of the face, neck, upper limbs, and trunk. This distribution of fat atrophy appears to be rare in comparison with previous reports. Sequencing of candidate genes LMNA, PPARG, AKT2, caveolin-1, as well as the PPARG4 promoter gene, which are known to be associated with familial partial lipodystrophy, revealed no genetic abnormalities, suggesting that this case may involve a novel gene. Pioglitazone was markedly effective in gl...
Source: Metabolism - Clinical and Experimental - September 30, 2009 Category: Biomedical Science Authors: Masanori Iwanishi, Ken Ebihara, Toru Kusakabe, Wen Chen, Jun Ito, Hiroaki Masuzaki, Kiminori Hosoda, Kazuwa Nakao Source Type: journals

Berberine improves free-fatty-acid–induced insulin resistance in L6 myotubes through inhibiting peroxisome proliferator–activated receptor γ and fatty acid transferase expressionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The plant alkaloid berberine (BBR) has been reported to have antidiabetic effect in humans and animals. However, the mechanism of action is not well understood. The present study was conducted to determine the effect and mechanism of action of BBR on the free-fatty-acid (FFA)–induced insulin resistance in muscle cells. The FFA-induced insulin-resistant cell model was established in L6 myotubes by treating them with 250 μmol/L of palmitic acid. The inclusion of FFA in the medium increased peroxisome proliferator–activated receptor γ (PPARγ) and fatty acid transferase (FAT/CD36) expressions by 26% and 50% an...
Source: Metabolism - Clinical and Experimental - September 22, 2009 Category: Biomedical Science Authors: Yanfeng Chen, Ying Li, Yanwen Wang, Ying Wen, Changhao Sun Source Type: journals

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Source: Metabolism - Clinical and Experimental - September 17, 2009 Category: Biomedical Science Tags: Frontmatter Source Type: journals

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Source: Metabolism - Clinical and Experimental - September 17, 2009 Category: Biomedical Science Tags: Frontmatter Source Type: journals

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Source: Metabolism - Clinical and Experimental - September 17, 2009 Category: Biomedical Science Tags: Frontmatter Source Type: journals

Metabolism 2008 Outside ReviewersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 17, 2009 Category: Biomedical Science Source Type: journals

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Source: Metabolism - Clinical and Experimental - September 17, 2009 Category: Biomedical Science Source Type: journals

Preliminary report: genetic variation within the GPBAR1 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Bile acids are signaling molecules with important endocrine functions. Some of these, including the induction of energy expenditure in brown adipose tissue and skeletal muscle as well as the stimulation of glucagon-like peptide–1 (GLP-1) production in enteroendocrine L-cells, are mediated by the G-protein–coupled bile acid receptor 1 (GPBAR1). Therefore, we investigated in a cohort of white subjects at increased risk for type 2 diabetes mellitus whether a genetic variation within the GPBAR1 gene contributes to prediabetic phenotypes, such as disproportionate fat distribution, insulin resistance, or β-cell dy...
Source: Metabolism - Clinical and Experimental - August 31, 2009 Category: Biomedical Science Authors: Karsten Müssig, Harald Staiger, Fausto Machicao, Jürgen Machann, Fritz Schick, Silke A. Schäfer, Claus D. Claussen, Jens J. Holst, Baptist Gallwitz, Norbert Stefan, Andreas Fritsche, Hans-Ulrich Häring Source Type: journals

Sonographic hepatic-renal ratio as indicator of hepatic steatosis: comparison with 1H magnetic resonance spectroscopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The aim of this study was to determine the diagnostic performance of ultrasound (US) in the quantitative assessment of steatosis by comparison with proton magnetic resonance spectroscopy (1H-MRS) as a reference standard. Three liver echo-intensity indices were derived: US hepatic mean gray level, hepatic-renal echo-intensity ratio (H/R), and hepatic-portal blood echo-intensity ratio. The 1H-MRS degree of steatosis was determined as percentage fat by wet weight. Regression equations were used to estimate quantitatively hepatic fat content. The hepatic fat content by 1H-MRS analysis ranged from 0.10% to 28.9% (medi...
Source: Metabolism - Clinical and Experimental - August 31, 2009 Category: Biomedical Science Authors: Marcello Mancini, Anna Prinster, Giovanni Annuzzi, Raffaele Liuzzi, Rosalba Giacco, Carmela Medagli, Matteo Cremone, Gennaro Clemente, Simone Maurea, Gabriele Riccardi, Angela Albarosa Rivellese, Marco Salvatore Source Type: journals

Hypoadiponectinemia in overweight children contributes to a negative metabolic risk profile 6 years laterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective was to study whether markers of metabolism and inflammation, for example, circulating plasma adiponectin, leptin, interleukin-8, and hepatocyte growth factor, are associated with cardiometabolic risk factors in childhood and adolescence. This was a cross-sectional and prospective study, and the setting was the Danish part of the European Youth Heart Studies I and II. Participants were randomly selected girls and boys 8 to 10 years of age with complete baseline data (n = 256) and complete follow-up data 6 years later (n = 169). Cardiometabolic risk profile was calculated using a continuous composite score deri...
Source: Metabolism - Clinical and Experimental - August 28, 2009 Category: Biomedical Science Authors: Iben Kynde, Berit L. Heitmann, Ib C. Bygbjerg, Lars B. Andersen, Jørn W. Helge Source Type: journals

Addition of n-3 fatty acids to a 4-hour lipid infusion does not affect insulin sensitivity, insulin secretion, or markers of oxidative stress in subjects with type 2 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Fatty acids (FA) can impair glucose metabolism to a varying degree depending on time of exposure and also of type of FA. Here we tested for acute effects of marine n-3 FA on insulin sensitivity, insulin secretion, energy metabolism, and oxidative stress. This was a randomized, double-blind, crossover study in 11 subjects with type 2 diabetes mellitus. A 4-hour lipid infusion (Intralipid [Fresenius Kabi, Halden, Norway], total of 384 mL) was compared with a similar lipid infusion partly replaced by Omegaven (Fresenius Kabi) that contributed a median of 0.1 g fish oil per kilogram body weight, amounting to 0.04 g/k...
Source: Metabolism - Clinical and Experimental - August 28, 2009 Category: Biomedical Science Authors: Ingrid L. Mostad, Kristian S. Bjerve, Samar Basu, Pauline Sutton, Keith N. Frayn, Valdemar Grill Source Type: journals

Homogenization-dependent responses of acid-soluble and acid-insoluble glycogen to exercise and refeeding in human musclesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the patterns of response of ASG and AIG levels to changes in glycogen concentrations in human muscles are highly dependent on the protocol used to acid-extract glycogen, with the physiologic significance of the many previous studies on AIG and ASG being in need of revision. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 26, 2009 Category: Biomedical Science Authors: Phillip D. Barnes, Anish Singh, Paul A. Fournier Source Type: journals

Effects of glucose infusion on neuroendocrine and cognitive parameters in Addison diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Sucrose intake has been shown to suppress increased adrenocorticotropic hormone (ACTH) levels in adrenalectomized rats, suggesting that increased cerebral energy supply can compensate for the loss of glucocorticoid feedback inhibition of the hypothalamo-pituitary-adrenal axis. We hypothesized that glucose infusion might acutely down-regulate increased ACTH secretion in patients with Addison disease. We studied 8 patients with primary adrenal insufficiency (Addison group) with short-term discontinuation of hydrocortisone substitution and 8 matched healthy controls in 2 randomized conditions. Subjects received eith...
Source: Metabolism - Clinical and Experimental - August 26, 2009 Category: Biomedical Science Authors: Johanna Klement, Christian Hubold, Manfred Hallschmid, Cecilia Loeck, Kerstin M. Oltmanns, Hendrik Lehnert, Jan Born, Achim Peters Source Type: journals

Levels of retinol-binding protein 4 and uric acid in patients with type 2 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, RBP4 level was independently associated with uric acid level. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 26, 2009 Category: Biomedical Science Authors: Ching-Chu Chen, Jer-Yuarn Wu, Chwen-Tzuei Chang, Fuu-Jen Tsai, Tzu-Yuan Wang, Yi-Min Liu, Huai-Chih Tsui, Rong-Hsing Chen, Shyh-Ching Chiou Source Type: journals

Reply: A potential role of the renin-angiotensin system in adipocyteEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have reported in this journal that plasma angiotensin II was associated with body weight, was decreased during weight loss, and was associated with adipocyte-derived factors and insulin resistance in obese subjects with type 2 diabetes mellitus . The letter from Drs Fetissov and Thornton gave sophisticated comments and good suggestions for our work. They have commented that, in obesity and type 2 diabetes mellitus, hypovolemia and extracellular dehydration were observed and the mechanism was tightly linked with the renin-angiotensin system . Furthermore, they have cited an article that mentioned that cell volume regulat...
Source: Metabolism - Clinical and Experimental - August 25, 2009 Category: Biomedical Science Authors: Atsuhito Saiki, Yoh Miyashita, Kohji Shirai Source Type: journals

Hypovolemia-induced obesity and diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The article by Saiki and colleagues published in the Metabolism entitled “Circulating angiotensin II is associated with body fat accumulation and insulin resistance in obese subjects with type 2 diabetes mellitus” is very interesting in that it points out clearly the association between circulating angiotensin levels and the pathophysiology of obesity and diabetes. At first glance, this is rather unusual, as why would a hormone intimately implicated in cardiovascular and water balance functions be involved with fat accumulation and insulin resistance. However, these “unusual” associations have given rise to a serie...
Source: Metabolism - Clinical and Experimental - August 25, 2009 Category: Biomedical Science Authors: Serguei O. Fetissov, Simon N. Thornton Source Type: journals

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Source: Metabolism - Clinical and Experimental - August 18, 2009 Category: Biomedical Science Tags: Frontmatter Source Type: journals

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Source: Metabolism - Clinical and Experimental - August 18, 2009 Category: Biomedical Science Tags: Frontmatter Source Type: journals

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Source: Metabolism - Clinical and Experimental - August 18, 2009 Category: Biomedical Science Tags: Frontmatter Source Type: journals

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Source: Metabolism - Clinical and Experimental - August 18, 2009 Category: Biomedical Science Source Type: journals

Effect of a 1-hour single bout of moderate-intensity exercise on fat oxidation kineticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study showed that the prior 1-hour continuous moderate-intensity exercise bout increased Fatmax, MFO, and fat oxidation rates over a wide range of intensities during the postexercise incremental test. Moreover, the shape of the postexercise fat oxidation kinetics tended to have a rightward asymmetry. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 27, 2009 Category: Biomedical Science Authors: Xavier Chenevière, Fabio Borrani, Vincent Ebenegger, Boris Gojanovic, Davide Malatesta Source Type: journals

Effects of dietary carbohydrate restriction versus low-fat diet on flow-mediated dilationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We previously reported that a carbohydrate-restricted diet (CRD) ameliorated many of the traditional markers associated with metabolic syndrome and cardiovascular risk compared with a low-fat diet (LFD). There remains concern how CRD affects vascular function because acute meals high in fat have been shown to impair endothelial function. Here, we extend our work and address these concerns by measuring fasting and postprandial vascular function in 40 overweight men and women with moderate hypertriacylglycerolemia who were randomly assigned to consume hypocaloric diets (∼1500 kcal) restricted in carbohydrate (per...
Source: Metabolism - Clinical and Experimental - July 27, 2009 Category: Biomedical Science Authors: Jeff S. Volek, Kevin D. Ballard, Ricardo Silvestre, Daniel A. Judelson, Erin E. Quann, Cassandra E. Forsythe, Maria Luz Fernandez, William J. Kraemer Source Type: journals

Treadmill training enhances rat agouti-related protein in plasma and reduces ghrelin levels in plasma and soleus muscleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Ghrelin and agouti-related protein (AgRP) are orexigenic peptides secreted from stomach mucosa and the arcuate nucleus of the hypothalamus, respectively. Both peptides affect feeding behavior and play a role in energy balance, glucose homeostasis, and adiposity. The purpose of the current study was to determine the effects of moderate-term (6 weeks) running regimen on resting levels of ghrelin, AgRP, adenosine triphosphate, and glycogen in soleus muscle as well as plasma concentrations of the orexigenic hormones. Eighteen adult Wistar male rats (12 weeks old, 235-255 g) were randomly assigned to training (n = 10)...
Source: Metabolism - Clinical and Experimental - July 27, 2009 Category: Biomedical Science Authors: Abbass Ghanbari-Niaki, Hossein Abednazari, Seyed Morteza Tayebi, Alireza Hossaini-Kakhak, Robert R. Kraemer Source Type: journals

Reproducibility of dual-energy x-ray absorptiometry total and regional body composition measurements using different scanning positions and definitions of regionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Repeated dual-energy x-ray absorptiometry (DEXA) measurements are often performed both in clinical work and in research studies. The aims of the present study were to investigate the repeatability of DEXA total body measurements, to clarify the effect of the scanning positioning of the subject, and to compare the reliability of DEXA measurements of the extremities between automatically and manually defined regions of interest (ROIs). Three DEXA measurements of the total body composition, that is, fat tissue mass, lean tissue mass (LM), and bone mineral content, were performed on 30 male volunteers (mean age, 45.2...
Source: Metabolism - Clinical and Experimental - July 26, 2009 Category: Biomedical Science Authors: Martina Lohman, Kaj Tallroth, Jyrki A. Kettunen, Markku T. Marttinen Source Type: journals

trans-Fatty acids in the diet stimulate atherosclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Epidemiological evidence has associated dietary trans-fatty acids (TFAs) with coronary heart disease. It is assumed that TFAs stimulate atherosclerosis, but this has not been proven. The purpose of this study was to determine the effects of consuming 2 concentrations of TFAs obtained from commercially hydrogenated vegetable shortening on atherosclerotic development in the presence or absence of elevated dietary cholesterol. Low-density lipoprotein receptor–deficient mice were fed 1 of 7 experimental diets for 14 weeks: low regular fat (LR), low trans-fat (LT), regular high fat, high trans-fat (HT), or a diet co...
Source: Metabolism - Clinical and Experimental - July 24, 2009 Category: Biomedical Science Authors: Chantal M.C. Bassett, Richelle S. McCullough, Andrea L. Edel, Thane G. Maddaford, Elena Dibrov, David P. Blackwood, Jose A. Austria, Grant N. Pierce Source Type: journals

Effects of low- and high-glycemic index/glycemic load diets on coronary heart disease risk factors in overweight/obese menEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Chronic insulin resistance contributes to subclinical inflammation, thrombosis/impaired fibrinolysis, and dyslipidemia. The effect of dietary carbohydrate, specifically of glycemic index (GI) and glycemic load (GL), on established and emerging coronary heart disease risk factors has not been elucidated fully. We conducted a randomized crossover feeding study of matched diets differing only in GI and GL in 24 overweight or obese but otherwise healthy men to investigate the effects on insulin sensitivity, inflammation, thrombosis/fibrinolysis, lipoproteins/lipids, and body composition. All meals for the high- and l...
Source: Metabolism - Clinical and Experimental - July 24, 2009 Category: Biomedical Science Authors: James M. Shikany, Radhika P. Phadke, David T. Redden, Barbara A. Gower Source Type: journals

Decreased parotid salivary cyclic nucleotides related to smell loss severity in patients with taste and smell dysfunctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Parotid salivary levels of cyclic adenosine monophosphate (cAMP) have been previously demonstrated to be lower than normal in patients with taste and smell dysfunction. To define these results more fully, we analyzed parotid salivary levels of cAMP and cyclic guanosine monophosphate (cGMP) with respect to severity of smell loss in these patients. Smell loss severity was defined by psychophysical measurements of olfactory function and classified into 4 types from most severe to least severe loss. This resulted in patients exhibiting, in order of loss severity (from greatest to least), anosmia > type I hyposmia > t...
Source: Metabolism - Clinical and Experimental - July 24, 2009 Category: Biomedical Science Authors: Robert Irwin Henkin, I. Velicu Source Type: journals

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Source: Metabolism - Clinical and Experimental - July 22, 2009 Category: Biomedical Science Tags: Frontmatter Source Type: journals

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Source: Metabolism - Clinical and Experimental - July 22, 2009 Category: Biomedical Science Tags: Frontmatter Source Type: journals

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Source: Metabolism - Clinical and Experimental - July 22, 2009 Category: Biomedical Science Tags: Frontmatter Source Type: journals

Erratum to “Insulin resistance predicts future deterioration of glucose tolerance in nondiabetic young African Americans”Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the May 2009 issue of Metabolism in the article by Huan et al (5:689-695, 2009), Harvey Kushner was erroneously listed as a co-author. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 22, 2009 Category: Biomedical Science Source Type: journals

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Source: Metabolism - Clinical and Experimental - July 22, 2009 Category: Biomedical Science Source Type: journals

Modifying the n-6/n-3 polyunsaturated fatty acid ratio of a high–saturated fat challenge does not acutely attenuate postprandial changes in inflammatory markers in men with metabolic syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Metabolic syndrome (MetS) features chronic inflammation and exaggerated postprandial triacylglyceride (TAG) responses. Fasting concentrations of interleukin-6 (IL-6) and C-reactive protein (CRP), key inflammatory mediators, decrease after sustained n-3 polyunsaturated fatty acid (PUFA) intake; however, the ability of n-3 PUFA to attenuate postprandial inflammatory responses is not well studied. Thus, we examined the acute effect of modifying the n-6/n-3 PUFA ratio of a high–saturated fatty acid (SFA) oral fat tolerance test (OFTT) on postprandial TAG and inflammatory responses in men with MetS. Men (n = 8, ≥4...
Source: Metabolism - Clinical and Experimental - July 22, 2009 Category: Biomedical Science Authors: Hilary M.F. Tulk, Lindsay E. Robinson Source Type: journals

Factors associated with serum high mobility group box 1 (HMGB1) levels in a general populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we examined these issues in a large population of healthy subjects. Fasting blood samples were obtained from 626 subjects (237 males and 389 females). HMGB1 levels showed a skewed distribution with a mean of 1.65 ± 0.04 ng/ml. Multiple stepwise regression analyses found that white blood cell (WBC) counts (P = .016) and the soluble form of receptor for advanced glycation end products (sRAGE; P < .001, inversely), which is also known to be a receptor for HMGB1, were independently associated with HMGB1 levels. We demonstrated for the first time that circulating HMGB1 levels were inversely associated with sRAGE...
Source: Metabolism - Clinical and Experimental - July 21, 2009 Category: Biomedical Science Authors: Ako Fukami, Hisashi Adachi, Sho-ichi Yamagishi, Takanori Matsui, Shin-ichiro Ueda, Kazuo Nakamura, Mika Enomoto, Maki Otsuka, Shun-ichi Kumagae, Yasuki Nanjo, Eita Kumagai, Eishi Esaki, Kyoko Murayama, Yuji Hirai, Tsutomu Imaizumi Source Type: journals

The roles of ubiquitin and 26S proteasome in human obesityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The ubiquitin-proteasome pathway is responsible for the degradation of most intracellular proteins in eukaryotes. It may also play a role in the modulation of inflammatory process and pathogenesis of cancer. Immunoglobulin levels are higher in cancer. Obesity is a risk factor for several common diseases, particularity type 2 diabetes mellitus, cardiovascular diseases, and tumors. The aim of this study was to study a possible correlation between plasma ubiquitin, 26S proteasome levels, and obesity. The body mass index (BMI), plasma ubiquitin levels, and 26S proteasome activity levels were determined and statistica...
Source: Metabolism - Clinical and Experimental - July 20, 2009 Category: Biomedical Science Authors: Tsui-Ling Chang, Chai-Jan Chang, Wen-Ying Lee, Miaw-Ning Lin, Yu-Wen Huang, Kang Fan Source Type: journals

Gene expression of paired abdominal adipose AQP7 and liver AQP9 in patients with morbid obesity: Relationship with glucose abnormalitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The trafficking of glycerol from adipose and hepatic tissue is mainly mediated by 2 aquaporin channel proteins: AQP7 and AQP9, respectively. In rodents, both aquaporins were found to act in a coordinated manner. The aim was to study the relationship between adipose AQP7 and hepatic AQP9 messenger RNA expression and the presence of glucose abnormalities simultaneously in morbid obesity. Adipose tissue (subcutaneous [SAT] and visceral [VAT]) and liver biopsies from the same patient were obtained during bariatric surgery in 30 (21 male and 9 female) morbidly obese subjects. Real-time quantification of AQP7 in SAT an...
Source: Metabolism - Clinical and Experimental - July 17, 2009 Category: Biomedical Science Authors: Merce Miranda, Victòria Ceperuelo-Mallafré, Albert Lecube, Cristina Hernandez, Matilde R. Chacon, Jose M. Fort, Lluís Gallart, Juan A. Baena-Fustegueras, Rafael Simó, Joan Vendrell Source Type: journals

Obesity and metabolic syndrome–related chronic kidney disease in nondiabetic, nonhypertensive adultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study is to examine the association between obesity and MS-related CKD in nondiabetic, nonhypertensive Korean adults. Korea National Health and Nutrition Examination Survey III data from 3771 nondiabetic, nonhypertensive Koreans were analyzed. Metabolic syndrome was defined according to the National Cholesterol Education Program–Adult Treatment Panel III, and CKD was diagnosed at an estimated glomerular filtration rate less than 60 mL/(min 1.73m2). The crude and multivariate-adjusted odds ratios (ORs) of CKD associated with MS and its individual components were calculated using logistic regression m...
Source: Metabolism - Clinical and Experimental - July 17, 2009 Category: Biomedical Science Authors: Yeong Sook Yoon, Hye Soon Park, Kyung Eun Yun, Soon Bae Kim Source Type: journals

Diabetes mellitus is associated with increased intramyocellular triglyceride, but not diglyceride, content in obese humansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: It has been suggested that intramyocellular diglycerides may be associated with insulin resistance and thus may be linked to the pathophysiology of diabetes. We aimed to investigate intramyocellular diglyceride as well as triglyceride levels in diabetic subjects and to explore a possible association with glycemic control. The participants of the study were 30 obese subjects stratified according to the presence of diabetes into nondiabetic obese (n = 19) and diabetic obese (n = 11). Intramyocellular triglycerides and diglycerides were determined in biopsies from the vastus lateralis muscle under fasting conditions...
Source: Metabolism - Clinical and Experimental - July 16, 2009 Category: Biomedical Science Authors: Costas A. Anastasiou, Stavros A. Kavouras, Yannis Lentzas, Afrodite Gova, Labros S. Sidossis, Adreas Melidonis Source Type: journals

Sex steroids deficiency impairs glucose transporter 4 expression and its translocation through defective Akt phosphorylation in target tissues of adult male ratEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: There is a substantial body of evidence suggesting that altered level of sex steroids in male is associated with insulin resistance and type 2 diabetes mellitus. However, the mechanism of this effect is not apparent. Our recent study indicated that testosterone deprivation decreases insulin receptor expression and glucose oxidation in insulin target tissues. The present study was designed to assess the impact of deficiency of testosterone and estradiol on Akt phosphorylation, glucose transporter expression, and glucose uptake in skeletal muscle, adipose tissue, and liver of adult male rat. Adult male albino rats ...
Source: Metabolism - Clinical and Experimental - July 16, 2009 Category: Biomedical Science Authors: Thirupathi Muthusamy, Palaniappan Murugesan, Karundevi Balasubramanian Source Type: journals

Consequences of head injury and static cold storage on hepatic function: ex vivo experiments using a model of isolated perfused rat liverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, static cold storage of livers harvested from HI rats revealed a net protein catabolism reduction and a modification of hepatic microcirculation. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 16, 2009 Category: Biomedical Science Authors: Eric Levesque, Christophe Moinard, Valérie Besson, Nathalie Neveux, Jean-Claude Chaumeil, Luc Cynober, Christine Charrueau Source Type: journals

Gestational high-fat programming impairs insulin release and reduces Pdx-1 and glucokinase immunoreactivity in neonatal Wistar ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Hyperglycemia and compromised β-cell development were demonstrated in neonatal rats programmed with a gestational high-fat diet. The aim of this study was to determine whether these changes were attributed to impaired insulin release and altered immunoreactivity of Pdx-1, glucokinase (GK), and glucose transporter (GLUT)–2 in high-fat–programmed neonates. Fetuses were maintained, via maternal nutrition, on either a standard laboratory diet (control) or a high-fat diet throughout gestation (HFG). Pancreata from 1-day–old neonates were excised for islet isolation and the subsequent measurement of insulin rele...
Source: Metabolism - Clinical and Experimental - July 16, 2009 Category: Biomedical Science Authors: Marlon E. Cerf, Charna S. Chapman, Christo J. Muller, Johan Louw Source Type: journals

Effect of grape seed extract on blood pressure in subjects with the metabolic syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was undertaken to determine whether grape seed extracts (GSE) that contain powerful vasodilator phenolic compounds lower blood pressure in subjects with the metabolic syndrome. The subjects were randomized into 3 groups—(a) placebo, (b) 150 mg GSE per day, and (c) 300 mg GSE per day—and treated for 4 weeks. Serum lipids and blood glucose were measured at the beginning of the study and at the end. Blood pressure was recorded using an ambulatory monitoring device at the start of the treatment period and at the end. Both the systolic and diastolic blood pressures were lowered after treatment with GSE as compare...
Source: Metabolism - Clinical and Experimental - July 16, 2009 Category: Biomedical Science Authors: Brahmesh Sivaprakasapillai, Indika Edirisinghe, Jody Randolph, Francene Steinberg, Tissa Kappagoda Source Type: journals