A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients
CONCLUSIONS: The combination of docetaxel/ADT and synthetic lycopene has low toxicity and favourable pharmacokinetics. The effects of lycopene on biomarkers provide additional support for the toxicity-dependent MTD definition.HIGHLIGHTS: The maximum tolerated dose was identified as 150 mg/day of lycopene in combination with docetaxel/ADT for the treatment of metastatic prostate cancer patients. Small increases in plasma exposure to docetaxel were observed with lycopene co-administration. Mechanistically significant effects were seen on angiogenesis and insulin-like growth factor 1 signalling by lycopene co-administration w...
Source: Methods of Information in Medicine - March 22, 2024 Category: Information Technology Authors: Michael B Lilly Chunli Wu Yu Ke Wen-Pin Chen Adam C Soloff Kent Armeson Noriko N Yokoyama Xiaotian Li Liankun Song Ying Yuan Christine E McLaren Xiaolin Zi Source Type: research

A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients
CONCLUSIONS: The combination of docetaxel/ADT and synthetic lycopene has low toxicity and favourable pharmacokinetics. The effects of lycopene on biomarkers provide additional support for the toxicity-dependent MTD definition.HIGHLIGHTS: The maximum tolerated dose was identified as 150 mg/day of lycopene in combination with docetaxel/ADT for the treatment of metastatic prostate cancer patients. Small increases in plasma exposure to docetaxel were observed with lycopene co-administration. Mechanistically significant effects were seen on angiogenesis and insulin-like growth factor 1 signalling by lycopene co-administration w...
Source: Methods of Information in Medicine - March 22, 2024 Category: Information Technology Authors: Michael B Lilly Chunli Wu Yu Ke Wen-Pin Chen Adam C Soloff Kent Armeson Noriko N Yokoyama Xiaotian Li Liankun Song Ying Yuan Christine E McLaren Xiaolin Zi Source Type: research

A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients
CONCLUSIONS: The combination of docetaxel/ADT and synthetic lycopene has low toxicity and favourable pharmacokinetics. The effects of lycopene on biomarkers provide additional support for the toxicity-dependent MTD definition.HIGHLIGHTS: The maximum tolerated dose was identified as 150 mg/day of lycopene in combination with docetaxel/ADT for the treatment of metastatic prostate cancer patients. Small increases in plasma exposure to docetaxel were observed with lycopene co-administration. Mechanistically significant effects were seen on angiogenesis and insulin-like growth factor 1 signalling by lycopene co-administration w...
Source: Methods of Information in Medicine - March 22, 2024 Category: Information Technology Authors: Michael B Lilly Chunli Wu Yu Ke Wen-Pin Chen Adam C Soloff Kent Armeson Noriko N Yokoyama Xiaotian Li Liankun Song Ying Yuan Christine E McLaren Xiaolin Zi Source Type: research

A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients
CONCLUSIONS: The combination of docetaxel/ADT and synthetic lycopene has low toxicity and favourable pharmacokinetics. The effects of lycopene on biomarkers provide additional support for the toxicity-dependent MTD definition.HIGHLIGHTS: The maximum tolerated dose was identified as 150 mg/day of lycopene in combination with docetaxel/ADT for the treatment of metastatic prostate cancer patients. Small increases in plasma exposure to docetaxel were observed with lycopene co-administration. Mechanistically significant effects were seen on angiogenesis and insulin-like growth factor 1 signalling by lycopene co-administration w...
Source: Methods of Information in Medicine - March 22, 2024 Category: Information Technology Authors: Michael B Lilly Chunli Wu Yu Ke Wen-Pin Chen Adam C Soloff Kent Armeson Noriko N Yokoyama Xiaotian Li Liankun Song Ying Yuan Christine E McLaren Xiaolin Zi Source Type: research

Development and Validation of a Natural Language Processing Algorithm to Pseudonymize Documents in the Context of a Clinical Data Warehouse
The objective of this study is to address the critical issue of deidentification of clinical reports to allow access to data for research purposes, while ensuring patient privacy. The study highlights the difficulties faced in sharing tools and resources in this domain and presents the experience of the Greater Paris University Hospitals (AP-HP for Assistance Publique-Hôpitaux de Paris) in implementing a systematic pseudonymization of text documents from its Clinical Data Warehouse.METHODS: We annotated a corpus of clinical documents according to 12 types of identifying entities and built a hybrid system, merging the res...
Source: Methods of Information in Medicine - March 5, 2024 Category: Information Technology Authors: Xavier Tannier Perceval Wajsb ürt Alice Calliger Basile Dura Alexandre Mouchet Martin Hilka Romain Bey Source Type: research

Development and Validation of a Natural Language Processing Algorithm to Pseudonymize Documents in the Context of a Clinical Data Warehouse
The objective of this study is to address the critical issue of deidentification of clinical reports to allow access to data for research purposes, while ensuring patient privacy. The study highlights the difficulties faced in sharing tools and resources in this domain and presents the experience of the Greater Paris University Hospitals (AP-HP for Assistance Publique-Hôpitaux de Paris) in implementing a systematic pseudonymization of text documents from its Clinical Data Warehouse.METHODS: We annotated a corpus of clinical documents according to 12 types of identifying entities and built a hybrid system, merging the res...
Source: Methods of Information in Medicine - March 5, 2024 Category: Information Technology Authors: Xavier Tannier Perceval Wajsb ürt Alice Calliger Basile Dura Alexandre Mouchet Martin Hilka Romain Bey Source Type: research

Development and Validation of a Natural Language Processing Algorithm to Pseudonymize Documents in the Context of a Clinical Data Warehouse
The objective of this study is to address the critical issue of deidentification of clinical reports to allow access to data for research purposes, while ensuring patient privacy. The study highlights the difficulties faced in sharing tools and resources in this domain and presents the experience of the Greater Paris University Hospitals (AP-HP for Assistance Publique-Hôpitaux de Paris) in implementing a systematic pseudonymization of text documents from its Clinical Data Warehouse.METHODS: We annotated a corpus of clinical documents according to 12 types of identifying entities and built a hybrid system, merging the res...
Source: Methods of Information in Medicine - March 5, 2024 Category: Information Technology Authors: Xavier Tannier Perceval Wajsb ürt Alice Calliger Basile Dura Alexandre Mouchet Martin Hilka Romain Bey Source Type: research

Development and Validation of a Natural Language Processing Algorithm to Pseudonymize Documents in the Context of a Clinical Data Warehouse
The objective of this study is to address the critical issue of deidentification of clinical reports to allow access to data for research purposes, while ensuring patient privacy. The study highlights the difficulties faced in sharing tools and resources in this domain and presents the experience of the Greater Paris University Hospitals (AP-HP for Assistance Publique-Hôpitaux de Paris) in implementing a systematic pseudonymization of text documents from its Clinical Data Warehouse.METHODS: We annotated a corpus of clinical documents according to 12 types of identifying entities and built a hybrid system, merging the res...
Source: Methods of Information in Medicine - March 5, 2024 Category: Information Technology Authors: Xavier Tannier Perceval Wajsb ürt Alice Calliger Basile Dura Alexandre Mouchet Martin Hilka Romain Bey Source Type: research

Development and Validation of a Natural Language Processing Algorithm to Pseudonymize Documents in the Context of a Clinical Data Warehouse
The objective of this study is to address the critical issue of deidentification of clinical reports to allow access to data for research purposes, while ensuring patient privacy. The study highlights the difficulties faced in sharing tools and resources in this domain and presents the experience of the Greater Paris University Hospitals (AP-HP for Assistance Publique-Hôpitaux de Paris) in implementing a systematic pseudonymization of text documents from its Clinical Data Warehouse.METHODS: We annotated a corpus of clinical documents according to 12 types of identifying entities and built a hybrid system, merging the res...
Source: Methods of Information in Medicine - March 5, 2024 Category: Information Technology Authors: Xavier Tannier Perceval Wajsb ürt Alice Calliger Basile Dura Alexandre Mouchet Martin Hilka Romain Bey Source Type: research

Development and Validation of a Natural Language Processing Algorithm to Pseudonymize Documents in the Context of a Clinical Data Warehouse
The objective of this study is to address the critical issue of deidentification of clinical reports to allow access to data for research purposes, while ensuring patient privacy. The study highlights the difficulties faced in sharing tools and resources in this domain and presents the experience of the Greater Paris University Hospitals (AP-HP for Assistance Publique-Hôpitaux de Paris) in implementing a systematic pseudonymization of text documents from its Clinical Data Warehouse.METHODS: We annotated a corpus of clinical documents according to 12 types of identifying entities and built a hybrid system, merging the res...
Source: Methods of Information in Medicine - March 5, 2024 Category: Information Technology Authors: Xavier Tannier Perceval Wajsb ürt Alice Calliger Basile Dura Alexandre Mouchet Martin Hilka Romain Bey Source Type: research

Development and Validation of a Natural Language Processing Algorithm to Pseudonymize Documents in the Context of a Clinical Data Warehouse
The objective of this study is to address the critical issue of deidentification of clinical reports to allow access to data for research purposes, while ensuring patient privacy. The study highlights the difficulties faced in sharing tools and resources in this domain and presents the experience of the Greater Paris University Hospitals (AP-HP for Assistance Publique-Hôpitaux de Paris) in implementing a systematic pseudonymization of text documents from its Clinical Data Warehouse.METHODS: We annotated a corpus of clinical documents according to 12 types of identifying entities and built a hybrid system, merging the res...
Source: Methods of Information in Medicine - March 5, 2024 Category: Information Technology Authors: Xavier Tannier Perceval Wajsb ürt Alice Calliger Basile Dura Alexandre Mouchet Martin Hilka Romain Bey Source Type: research

Development and Validation of a Natural Language Processing Algorithm to Pseudonymize Documents in the Context of a Clinical Data Warehouse
The objective of this study is to address the critical issue of deidentification of clinical reports to allow access to data for research purposes, while ensuring patient privacy. The study highlights the difficulties faced in sharing tools and resources in this domain and presents the experience of the Greater Paris University Hospitals (AP-HP for Assistance Publique-Hôpitaux de Paris) in implementing a systematic pseudonymization of text documents from its Clinical Data Warehouse.METHODS: We annotated a corpus of clinical documents according to 12 types of identifying entities and built a hybrid system, merging the res...
Source: Methods of Information in Medicine - March 5, 2024 Category: Information Technology Authors: Xavier Tannier Perceval Wajsb ürt Alice Calliger Basile Dura Alexandre Mouchet Martin Hilka Romain Bey Source Type: research

Development and Validation of a Natural Language Processing Algorithm to Pseudonymize Documents in the Context of a Clinical Data Warehouse
The objective of this study is to address the critical issue of deidentification of clinical reports to allow access to data for research purposes, while ensuring patient privacy. The study highlights the difficulties faced in sharing tools and resources in this domain and presents the experience of the Greater Paris University Hospitals (AP-HP for Assistance Publique-Hôpitaux de Paris) in implementing a systematic pseudonymization of text documents from its Clinical Data Warehouse.METHODS: We annotated a corpus of clinical documents according to 12 types of identifying entities and built a hybrid system, merging the res...
Source: Methods of Information in Medicine - March 5, 2024 Category: Information Technology Authors: Xavier Tannier Perceval Wajsb ürt Alice Calliger Basile Dura Alexandre Mouchet Martin Hilka Romain Bey Source Type: research

Development and Validation of a Natural Language Processing Algorithm to Pseudonymize Documents in the Context of a Clinical Data Warehouse
The objective of this study is to address the critical issue of deidentification of clinical reports to allow access to data for research purposes, while ensuring patient privacy. The study highlights the difficulties faced in sharing tools and resources in this domain and presents the experience of the Greater Paris University Hospitals (AP-HP for Assistance Publique-Hôpitaux de Paris) in implementing a systematic pseudonymization of text documents from its Clinical Data Warehouse.METHODS: We annotated a corpus of clinical documents according to 12 types of identifying entities and built a hybrid system, merging the res...
Source: Methods of Information in Medicine - March 5, 2024 Category: Information Technology Authors: Xavier Tannier Perceval Wajsb ürt Alice Calliger Basile Dura Alexandre Mouchet Martin Hilka Romain Bey Source Type: research

Development and Validation of a Natural Language Processing Algorithm to Pseudonymize Documents in the Context of a Clinical Data Warehouse
The objective of this study is to address the critical issue of deidentification of clinical reports to allow access to data for research purposes, while ensuring patient privacy. The study highlights the difficulties faced in sharing tools and resources in this domain and presents the experience of the Greater Paris University Hospitals (AP-HP for Assistance Publique-Hôpitaux de Paris) in implementing a systematic pseudonymization of text documents from its Clinical Data Warehouse.METHODS: We annotated a corpus of clinical documents according to 12 types of identifying entities and built a hybrid system, merging the res...
Source: Methods of Information in Medicine - March 5, 2024 Category: Information Technology Authors: Xavier Tannier Perceval Wajsb ürt Alice Calliger Basile Dura Alexandre Mouchet Martin Hilka Romain Bey Source Type: research