Mini Reviews in Medicinal Chemistry 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.1,3,4-Oxadiazole Scaffold in Antidiabetic Drug Discovery: An Overview
Mini Rev Med Chem. 2024 Apr 19. doi: 10.2174/0113895575298181240410041029. Online ahead of print.ABSTRACTDiabetes mellitus is one of the biggest challenges for the scientific community in the 21st century. With the increasing number of cases of diabetes and drug-resistant diabetes, there is an urgent need to develop new potent molecules capable of combating this cruel disease. Medicinal chemistry concerns the discovery, development, identification, and interpretation of the mode of action of biologically active compounds at the molecular level. Oxadiazole-based derivatives have come up as a potential option for antidiabeti...
Source: Mini Reviews in Medicinal Chemistry - April 22, 2024 Category: Chemistry Authors: Ojasvi Gupta Gita Chawla Tathagata Pradhan Source Type: research
Aloe-emodin: Progress in Pharmacological Activity, Safety, and Pharmaceutical Formulation Applications
Mini Rev Med Chem. 2024 Apr 18. doi: 10.2174/0113895575298364240409064833. Online ahead of print.ABSTRACTAloe-emodin (AE) is an anthraquinone derivative and a biologically active component sourced from various plants, including Rheum palmatum L. and Aloe vera. Known chemically as 1,8-dihydroxy-3-hydroxymethyl-anthraquinone, AE has a rich history in traditional medicine and is esteemed for its accessibility, safety, affordability, and effectiveness. AE boasts multiple biochemical and pharmacological properties, such as strong antibacterial, antioxidant, and antitumor effects. Despite its array of benefits, AE's identity as ...
Source: Mini Reviews in Medicinal Chemistry - April 19, 2024 Category: Chemistry Authors: Haimeng Luoa Xiaoyun Jia Mengyu Zhanga Yaoyao Renb Rui Tana Hezhong Jianga Xiaoqing Wua Source Type: research
Polyphenols Modulate the miRNAs Expression that Involved in Glioblastoma
Mini Rev Med Chem. 2024 Apr 18. doi: 10.2174/0113895575304605240408105201. Online ahead of print.ABSTRACTGlioblastoma multiforme (GBM), a solid tumor that develops from astrocytes, is one of the most aggressive types of brain cancer. While there have been improvements in the efficacy of treating GBM, many problems remain, especially with traditional therapy methods. Therefore, recent studies have extensively focused on developing novel therapeutic agents for combating glioblastoma. Natural polyphenols have been studied for their potential as chemopreventive and chemotherapeutic agents due to their wide range of positive qu...
Source: Mini Reviews in Medicinal Chemistry - April 19, 2024 Category: Chemistry Authors: Maede Rezaie Mohammad Nasehi Mohammad Shimia Mohamad Ebrahimnezhad Bahman Yousefi Maryam Majidinia Source Type: research
Schiff Bases: A Captivating Scaffold with Potential Anticonvulsant Activity
Mini Rev Med Chem. 2024 Apr 16. doi: 10.2174/0113895575302197240408121537. Online ahead of print.ABSTRACTOne of the most important organic compounds, also known as a Schiff base, imine, or azomethine, has been associated with several biological processes. The group is a component of both natural or synthetic chemicals and functions as both a precursor and an intermediary in the synthesis of therapeutically active substances. The review highlights the various non-metal Schiff bases' structure-activity relationship (SAR) studies, general model, docking, and design approach for anticonvulsant actions. Schiff bases serve as li...
Source: Mini Reviews in Medicinal Chemistry - April 17, 2024 Category: Chemistry Authors: Rakesh Sahu Kamal Shah Source Type: research
Schiff Bases: A Captivating Scaffold with Potential Anticonvulsant Activity
Mini Rev Med Chem. 2024 Apr 16. doi: 10.2174/0113895575302197240408121537. Online ahead of print.ABSTRACTOne of the most important organic compounds, also known as a Schiff base, imine, or azomethine, has been associated with several biological processes. The group is a component of both natural or synthetic chemicals and functions as both a precursor and an intermediary in the synthesis of therapeutically active substances. The review highlights the various non-metal Schiff bases' structure-activity relationship (SAR) studies, general model, docking, and design approach for anticonvulsant actions. Schiff bases serve as li...
Source: Mini Reviews in Medicinal Chemistry - April 17, 2024 Category: Chemistry Authors: Rakesh Sahu Kamal Shah Source Type: research
The Pivotal Function of SLC16A1 and SLC16A1-AS1 in Cancer Progress: Molecular Pathogenesis and Prognosis
Mini Rev Med Chem. 2024 Apr 8. doi: 10.2174/0113895575284780240327103039. Online ahead of print.ABSTRACTMore than 300 membranes make up the SLC family of transporters, utilizing an ion gradient or electrochemical potential difference to move their substrates across biological membranes. The SLC16 gene family contains fourteen members. Proton-linked transportation of monocarboxylates can be promoted by the transporters MCT1, which the SLC16A1 gene family encodes. Glycolysis is constitutively up-regulated in cancer cells, and the amount of lactate produced as a result is correlated with prognosis. Further speaking, SLC16A1 p...
Source: Mini Reviews in Medicinal Chemistry - April 15, 2024 Category: Chemistry Authors: Yunxi Zhou Fangshun Tan Zhuowei Wang Gang Zhou Chengfu Yuan Source Type: research
The Pivotal Function of SLC16A1 and SLC16A1-AS1 in Cancer Progress: Molecular Pathogenesis and Prognosis
Mini Rev Med Chem. 2024 Apr 8. doi: 10.2174/0113895575284780240327103039. Online ahead of print.ABSTRACTMore than 300 membranes make up the SLC family of transporters, utilizing an ion gradient or electrochemical potential difference to move their substrates across biological membranes. The SLC16 gene family contains fourteen members. Proton-linked transportation of monocarboxylates can be promoted by the transporters MCT1, which the SLC16A1 gene family encodes. Glycolysis is constitutively up-regulated in cancer cells, and the amount of lactate produced as a result is correlated with prognosis. Further speaking, SLC16A1 p...
Source: Mini Reviews in Medicinal Chemistry - April 15, 2024 Category: Chemistry Authors: Yunxi Zhou Fangshun Tan Zhuowei Wang Gang Zhou Chengfu Yuan Source Type: research
The Indispensable Roles of GMDS and GMDS-AS1 in the Advancement of Cancer: Fucosylation, Signal Pathway and Molecular Pathogenesis
Mini Rev Med Chem. 2024 Apr 5. doi: 10.2174/0113895575285276240324080234. Online ahead of print.ABSTRACTFucosylation is facilitated by converting GDP-mannose to GDP-4-keto-6-deoxymannose, which GDP-mannose 4,6-dehydratase, a crucial enzyme in the route, carries out. One of the most prevalent glycosylation alterations linked to cancer has reportedly been identified as fucosylation. There is mounting evidence that GMDS is intimately linked to the onset and spread of cancer. Furthermore, the significance of long-chain non-coding RNAs in the development and metastasis of cancer is becoming more well-recognized, and the regulat...
Source: Mini Reviews in Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Ziyan Zhang Zhuowei Wang Hong Fan Jiayi Li Jiaqi Ding Gang Zhou Chengfu Yuan Source Type: research
The Indispensable Roles of GMDS and GMDS-AS1 in the Advancement of Cancer: Fucosylation, Signal Pathway and Molecular Pathogenesis
Mini Rev Med Chem. 2024 Apr 5. doi: 10.2174/0113895575285276240324080234. Online ahead of print.ABSTRACTFucosylation is facilitated by converting GDP-mannose to GDP-4-keto-6-deoxymannose, which GDP-mannose 4,6-dehydratase, a crucial enzyme in the route, carries out. One of the most prevalent glycosylation alterations linked to cancer has reportedly been identified as fucosylation. There is mounting evidence that GMDS is intimately linked to the onset and spread of cancer. Furthermore, the significance of long-chain non-coding RNAs in the development and metastasis of cancer is becoming more well-recognized, and the regulat...
Source: Mini Reviews in Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Ziyan Zhang Zhuowei Wang Hong Fan Jiayi Li Jiaqi Ding Gang Zhou Chengfu Yuan Source Type: research
The Indispensable Roles of GMDS and GMDS-AS1 in the Advancement of Cancer: Fucosylation, Signal Pathway and Molecular Pathogenesis
Mini Rev Med Chem. 2024 Apr 5. doi: 10.2174/0113895575285276240324080234. Online ahead of print.ABSTRACTFucosylation is facilitated by converting GDP-mannose to GDP-4-keto-6-deoxymannose, which GDP-mannose 4,6-dehydratase, a crucial enzyme in the route, carries out. One of the most prevalent glycosylation alterations linked to cancer has reportedly been identified as fucosylation. There is mounting evidence that GMDS is intimately linked to the onset and spread of cancer. Furthermore, the significance of long-chain non-coding RNAs in the development and metastasis of cancer is becoming more well-recognized, and the regulat...
Source: Mini Reviews in Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Ziyan Zhang Zhuowei Wang Hong Fan Jiayi Li Jiaqi Ding Gang Zhou Chengfu Yuan Source Type: research
The Indispensable Roles of GMDS and GMDS-AS1 in the Advancement of Cancer: Fucosylation, Signal Pathway and Molecular Pathogenesis
Mini Rev Med Chem. 2024 Apr 5. doi: 10.2174/0113895575285276240324080234. Online ahead of print.ABSTRACTFucosylation is facilitated by converting GDP-mannose to GDP-4-keto-6-deoxymannose, which GDP-mannose 4,6-dehydratase, a crucial enzyme in the route, carries out. One of the most prevalent glycosylation alterations linked to cancer has reportedly been identified as fucosylation. There is mounting evidence that GMDS is intimately linked to the onset and spread of cancer. Furthermore, the significance of long-chain non-coding RNAs in the development and metastasis of cancer is becoming more well-recognized, and the regulat...
Source: Mini Reviews in Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Ziyan Zhang Zhuowei Wang Hong Fan Jiayi Li Jiaqi Ding Gang Zhou Chengfu Yuan Source Type: research
Structural Perspectives in the Development of Novel EGFR Inhibitors for the Treatment of NSCLC
Mini Rev Med Chem. 2024 Apr 4. doi: 10.2174/0113895575296174240323172754. Online ahead of print.ABSTRACTNon-small cell Lung cancer (NSCLC) is the most common type of lung cancer, which is caused by high consumption of tobacco and smoking. It is an epithelial lung cancer that affects about 2.2 million people across the globe, according to International Agency for Research on Cancer (IARC). Non-small cell lung cancer is a malignant tumor caused by EGFR mutation that occurs in the in-frame deletion of exon 19 and L858R point mutation in exon 21. Presently, clinically available inhibitors of EGFR (including erlotinib, lapatini...
Source: Mini Reviews in Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Rahul Makhija Anushka Sharma Rahul Dubey Vivek Asati Source Type: research
Structural Perspectives in the Development of Novel EGFR Inhibitors for the Treatment of NSCLC
Mini Rev Med Chem. 2024 Apr 4. doi: 10.2174/0113895575296174240323172754. Online ahead of print.ABSTRACTNon-small cell Lung cancer (NSCLC) is the most common type of lung cancer, which is caused by high consumption of tobacco and smoking. It is an epithelial lung cancer that affects about 2.2 million people across the globe, according to International Agency for Research on Cancer (IARC). Non-small cell lung cancer is a malignant tumor caused by EGFR mutation that occurs in the in-frame deletion of exon 19 and L858R point mutation in exon 21. Presently, clinically available inhibitors of EGFR (including erlotinib, lapatini...
Source: Mini Reviews in Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Rahul Makhija Anushka Sharma Rahul Dubey Vivek Asati Source Type: research
Diabetes Pharmacotherapy and its effects on the Skeletal Muscle Energy Metabolism
Mini Rev Med Chem. 2024 Feb 16. doi: 10.2174/0113895575299439240216081711. Online ahead of print.ABSTRACTThe disorders of skeletal muscle metabolism in patients with Type 2 diabetes mellitus (T2DM), such as mitochondrial defection and glucose transporters (GLUTs) translocation dysfunctions, are not uncommon. Therefore, when anti-diabetic drugs were used in various chronic diseases associated with hyperglycemia, the impact on skeletal muscle should not be ignored. However, current studies mainly focus on muscle mass rather than metabolism or functions. Anti-diabetic drugs might have a harmful or beneficial impact on skeleta...
Source: Mini Reviews in Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Baowen Yu Dong Wang Junming Zhou Rong Huang Tingting Cai Yonghui Hu Yunting Zhou Jianhua Ma Source Type: research
Diabetes Pharmacotherapy and its effects on the Skeletal Muscle Energy Metabolism
Mini Rev Med Chem. 2024 Feb 16. doi: 10.2174/0113895575299439240216081711. Online ahead of print.ABSTRACTThe disorders of skeletal muscle metabolism in patients with Type 2 diabetes mellitus (T2DM), such as mitochondrial defection and glucose transporters (GLUTs) translocation dysfunctions, are not uncommon. Therefore, when anti-diabetic drugs were used in various chronic diseases associated with hyperglycemia, the impact on skeletal muscle should not be ignored. However, current studies mainly focus on muscle mass rather than metabolism or functions. Anti-diabetic drugs might have a harmful or beneficial impact on skeleta...
Source: Mini Reviews in Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Baowen Yu Dong Wang Junming Zhou Rong Huang Tingting Cai Yonghui Hu Yunting Zhou Jianhua Ma Source Type: research
