Beta hydroxybutyrate induces lung cancer cell death, mitochondrial impairment and oxidative stress in a long term glucose-restricted condition
CONCLUSION: The induced cell death, oxidative stress and mitochondria impairment beside attenuated levels of cancer stem cell markers following BHB administration emphasize on the distinctive role of metabolic plasticity of cancer cells and propose possible therapeutic approaches to control cancer cell growth through metabolic fuels.PMID:38656394 | DOI:10.1007/s11033-024-09501-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 24, 2024 Category: Molecular Biology Authors: Farzad Izak Shirian Milad Karimi Maryam Alipour Siamak Salami Mitra Nourbakhsh Samira Nekufar Nahid Safari-Alighiarloo Masoumeh Tavakoli-Yaraki Source Type: research
Thrombus or tumor? A case report of a rare sarcoma entity: intimal sarcoma of the pulmonary arteries
CONCLUSION: In case of atypical presentation of a pulmonary embolism, a tumor originating from the great vessels should be considered. Molecular pathology techniques support in establishing a reliable diagnosis.PMID:38656400 | DOI:10.1007/s11033-024-09467-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 24, 2024 Category: Molecular Biology Authors: A D örr A Fl örcken L Bullinger D Capper A Von Deimling D Kaul S M ärdian C Starck D Horst M P Dragomir F M Sch äfer A Jarosch Source Type: research
Unlocking the potential of adeno-associated virus in neuroscience: a brief review
Mol Biol Rep. 2024 Apr 22;51(1):563. doi: 10.1007/s11033-024-09521-6.ABSTRACTAdeno-associated virus (AAV) has emerged as a pivotal tool in neuroscience research, owing to its remarkable versatility and efficiency in delivering genetic material to diverse cell types within the nervous system. This mini review aims to underscore the advanced applications of AAV vectors in neuroscience and their profound potential to revolutionize our understanding of brain function and therapeutic interventions for neurological disorders. By providing a concise overview of the latest developments and strategies employing AAV vectors, this re...
Source: Molecular Biology Reports - April 22, 2024 Category: Molecular Biology Authors: Antea Minetti Source Type: research
The ras-related protein RAB22A interacts with hypoxia-inducible factor 1-alpha (HIF-1 α) in MDA-MB-231 breast cancer cells in hypoxia
CONCLUSIONS: Our study is the first to reveal the potential involvement of HIF-1α in intracellular trafficking through physical interactions with the small GTPase protein RAB22A. We discuss the implications of our work on the role of exosomes and microvesicles in tumor invasiveness.PMID:38647725 | DOI:10.1007/s11033-024-09516-3 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 22, 2024 Category: Molecular Biology Authors: Nikolaos A Papanikolaou Maria Kakavoulia Christos Ladias Athanasios G Papavassiliou Source Type: research
Correction: Long-term antigen-specific immune response by an oncolytic adenovirus encoding SP-SA-E7-4-1BBL in HPV-16 cancer model
Mol Biol Rep. 2024 Apr 22;51(1):565. doi: 10.1007/s11033-024-09489-3.NO ABSTRACTPMID:38649646 | DOI:10.1007/s11033-024-09489-3 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 22, 2024 Category: Molecular Biology Authors: Alejandra G Martinez-Perez Rodolfo Garza-Morales Maria J de Loera-Arias Sheila A Villa-Cedillo Aracely Garcia-Garcia Humberto Rodriguez-Rocha Orlando E Flores-Maldonado Jesus Valdes Jose J Perez-Trujillo Odila Saucedo-Cardenas Source Type: research
A rare KMT2A::CBL transcript in an acute monoblastic leukemia patient with an unfavorable outcome
CONCLUSIONS: This report provides novel insights into the leukemogenic potential of the KMT2A::CBL rearrangement and the correlation between gene rearrangements and clinical outcomes.PMID:38643442 | PMC:PMC11033236 | DOI:10.1007/s11033-024-09543-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 21, 2024 Category: Molecular Biology Authors: Jinglei Yu Fengmei Song Mingming Zhang Pingnan Xiao Jingjing Feng Ruimin Hong Yongxian Hu He Huang Guoqing Wei Source Type: research
Dapagliflozin promotes browning of white adipose tissue through the FGFR1-LKB1-AMPK signaling pathway
CONCLUSION: These findings provide a rational basis for the use of DAPA in treating obesity by promoting the browning of white adipose tissue.PMID:38644407 | PMC:PMC11033239 | DOI:10.1007/s11033-024-09540-3 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 21, 2024 Category: Molecular Biology Authors: Yue Lv Chengrui Zhao Qiuyan Jiang Yilin Rong Mingfeng Ma Lili Liang Weiping Li Jiuxuan Zhang Ning Xu Huiwen Wu Source Type: research
Evaluation of capillary miR-122 as a prognostic biomarker of paracetamol-induced liver toxicity
CONCLUSION: This work supports the potential use of capillary miR-122 as a prognostic biomarker of liver injury throughout clinical management of patients with paracetamol overdose. Capillary miR-122 can be measured in a blood drop collected by a finger prick, a minimally invasive diagnostic test for patient stratification.PMID:38642142 | DOI:10.1007/s11033-024-09327-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 20, 2024 Category: Molecular Biology Authors: Marco Cirronis Sarah Schneemann Janice Pettie Guido Mannaioni James W Dear Source Type: research
The MMP-9 promoter genetic variant rs3918242, mRNA and protein expression in advanced carotid plaque tissue
CONCLUSIONS: Considering the differences of MMP-9 mRNA and protein expression in CP tissue regarding different plaque phenotypes and the observed sex-specific effect, the role of MMP-9 in human atherosclerotic plaques should be further elucidated.PMID:38642151 | DOI:10.1007/s11033-024-09458-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 20, 2024 Category: Molecular Biology Authors: Maja Zivkovic Aleksandra Stankovic Igor Koncar Ana Kolakovic Maja Boskovic Tamara Djuric Source Type: research
Overexpression of WT1 in all molecular subtypes of breast cancer and its impact on survival: exploring oncogenic and tumor suppressor roles of distinct WT1 isoforms
CONCLUSIONS: Interestingly, this overexpression was observed in all molecular subtypes of invasive breast cancer, underscoring the significance of WT1 as a potential target in all these subtypes. The observed WT1 down-expression in a few cases of invasive breast cancer, associated with better survival outcomes, may correspond to the down-regulation of a particular WT1-KTS (-) isoform: the WT1 A isoform (EX5-/KTS-). The co-expression of this WT1 oncogenic isoform with a regulated WT1- tumor suppressor isoform, such as the major WT1 F isoform (EX5-/KTS +), could also explain such survival outcomes. Due to its capacity to ado...
Source: Molecular Biology Reports - April 20, 2024 Category: Molecular Biology Authors: Hind Ben Haj Othmen Houcemeddine Othman Oussema Khamessi Ilhem Bettaieb Sonia Gara Maher Kharrat Source Type: research
A novel SOX10 mutation causing Waardenburg syndrome type 2 by expressing a truncated and dysfunctional protein in a Chinese child
CONCLUSIONS: Our findings helped to understand the genotype-phenotype association in WS2 cases with SOX10 mutations.PMID:38642155 | DOI:10.1007/s11033-024-09469-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 20, 2024 Category: Molecular Biology Authors: Zhongxia Li Ke Xu Zhumei Zhou Chi Liang Weiyue Gu Jianyu Ran Source Type: research
The endonuclease FEN1 mediates activation of STAT3 and facilitates proliferation and metastasis in breast cancer
CONCLUSIONS: These results indicate a novel mechanism that NF-κB-driven FEN1 contributes to promoting BRCA growth and metastasis by STAT3 activation.PMID:38642158 | DOI:10.1007/s11033-024-09524-3 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 20, 2024 Category: Molecular Biology Authors: Min Wu Xiaoshan Huang Benmeng Wu Miaolin Zhu Yaqin Zhu Lin Yu Ting Lan Jingjing Liu Source Type: research
Correction: MicroRNA ‑499‑5p inhibits transforming growth factor‑β1‑induced Smad2 signaling pathway and suppresses fibroblast proliferation and collagen synthesis in rat by targeting TGFβ‑R1
Mol Biol Rep. 2024 Apr 20;51(1):552. doi: 10.1007/s11033-024-09226-w.NO ABSTRACTPMID:38642166 | PMC:PMC11032292 | DOI:10.1007/s11033-024-09226-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 20, 2024 Category: Molecular Biology Authors: Qing Zhao Wentao Yang Xiangdong Li Hongtao Yuan Jianping Guo Yutang Wang Zhaoliang Shan Source Type: research
Study on endolichenic fungal assemblage in Parmotrema and Heterodermia lichens of Shivamoga, Karnataka
CONCLUSIONS: The observation highlights that the deciduous forest harness a high number of endolichenic fungi, a dominant portion of these fungi are non-sporulating and still exist as cryptic. Overall, 8 ELF species recognized based on phylogenetic analysis, including the two newly reported fungi ELFX03 and ELFX06 which are suspected to be new species based on the present evidence. The study proved, that the lichen being rich source to establish fungal diversity and finding new species. Successful amplification of most phylogenetic markers like RPB2, building of comprehensive taxonomic databases and application of multi-om...
Source: Molecular Biology Reports - April 20, 2024 Category: Molecular Biology Authors: D Pushpavathi Y L Krishnamurthy Source Type: research
Investigating the role of itaconate in macrophage activation and oxidative stress injury in sepsis-associated acute kidney injury
CONCLUSIONS: This investigation offers new proof to support the itaconate function in the development and progression of SA-AKI and shows a new possible therapeutic agent for the SA-AKI treatment.PMID:38642169 | DOI:10.1007/s11033-024-09462-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 20, 2024 Category: Molecular Biology Authors: Lei Yang Pei Zhou Ruidong Li Yuping Yin Gengchen Xie Liang Shi Peng Zhang Kaixiong Tao Source Type: research
