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Transcriptomic analysis of pathways regulated by toll-like receptor 4 in a murine model of chronic pulmonary inflammation and carcinogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This transcriptomic study determined the protective effect of TLR4 in lung carcinogenesis inhibition of multiple pathways including EGFR (e.g. Ereg), inflammatory response genes (e.g. Cxcl5), chemotaxis (e.g. Ccr1) and other cell proliferation genes (e.g. Arg1, Pthlh). Future studies will determine the utility of these pathways as indicators of immune system deficiencies and tumorigenesis. (Source: Molecular Cancer)
Source: Molecular Cancer - November 19, 2009 Category: Cancer & Oncology Authors: Alison BauerJennifer FostelLaura DegraffElizabeth RondiniChristopher WalkerSherry GrissomJulie FoleySteven Kleeberger Source Type: journals

iNOS activity is necessary for the cytotoxic and immunogenic effects of doxorubicin in human colon cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data suggest that chemo- and immuno-resistance to anthracyclines are associated in colon cancer cells and rely on a common mechanism, that is the inability of doxorubicin to induce iNOS. Therefore NO donors might represent a promising strategy to restore both chemosensitivity and immunosensitivity to doxorubicin in resistant cells. (Source: Molecular Cancer)
Source: Molecular Cancer - November 19, 2009 Category: Cancer & Oncology Authors: Sara De BooJoanna KopeckaDavide BrusaElena GazzanoLina MateraDario GhigoAmalia BosiaChiara Riganti Source Type: journals

Selective depletion of a minor subpopulation of B-chronic lymphocytic leukemia cells is followed by a delayed but progressive loss of bulk tumor cells and disease regressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cancer precursor/progenitor cells may initiate and sustain the growth of tumors, but evidence for their existence in human disease is indirect, relying on their in vitro properties and animal models. More directly, specific elimination of these rare cells from cancer patients should produce a delayed but progressive disappearance of differentiated malignant progeny. Here, we describe selective eradication of a putative precursor population in a patient with B-cell chronic lymphocytic leukemia, followed 6 months later by a progressive loss of mature tumor cells without further treatment. This outcome supports the presence o...
Source: Molecular Cancer - November 18, 2009 Category: Cancer & Oncology Authors: Aaron FosterFatma OkurEttore BiagiAn LuGianpietro DottiEric YvonBarbara SavoldoGeorge CarrumMichael AndreeffMargaret GoodellHelen HeslopMalcolm Brenner Source Type: journals

Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: With the aim to simplify cancer management, cancer research lately dedicated itself more and more to discover and develop non-invasive biomarkers. In this connection, circulating cell-free DNA (ccf DNA) seems to be a promising candidate. Altered levels of ccf nuclear DNA (nDNA) and mitochondrial DNA (mtDNA) have been found in several cancer types and might have a diagnostic value.MethodUsing multiplex real-time PCR we investigated the levels of ccf nDNA and mtDNA in plasma samples from patients with malignant and benign breast tumors, and from healthy controls. To evaluate the applicability of plasma ccf nDNA a...
Source: Molecular Cancer - November 17, 2009 Category: Cancer & Oncology Authors: Corina KohlerRamin RadpourZeinab BarekatiReza AsadollahiJohannes BitzerEdward WightNicole BuerkiClaude DieschWolfgang HolzgreveXiao Yan Zhong Source Type: journals

Expression and function of hypoxia inducible factor-1 alpha in human melanoma under non-hypoxic conditionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We speculate that metabolic products of U0126 decrease HIF-1alpha expression through "off target" effects. Overall our data suggest that increased HIF-1alpha expression under normoxic conditions contributes to some of the malignant phenotypes exhibited by human melanoma cells. The expanded role of HIF-1alpha in melanoma biology increases its importance as a therapeutic target. (Source: Molecular Cancer)
Source: Molecular Cancer - November 17, 2009 Category: Cancer & Oncology Authors: Caroline MillsSandeep JoshiRichard Niles Source Type: journals

Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These findings show for the first time that elevated expression of p53-R175H mutant may exert gain-of-function activity to activate the EGFR/PI3K/AKT pathway and thus may contribute to the invasive phenotype in endometrial cancer. (Source: Molecular Cancer)
Source: Molecular Cancer - November 16, 2009 Category: Cancer & Oncology Authors: Peixin DongZhujie XuNan JiaDajin LiYouji Feng Source Type: journals

MicroRNAs in colorectal cancer: translation of molecular biology into clinical applicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
MicroRNAs (miRNAs) are small non-coding RNAs 18-25 nucleotides in length that downregulate gene expression during various crucial cell processes such as apoptosis, differentiation and development. Changes in the expression profiles of miRNAs have been observed in a variety of human tumors, including colorectal cancer (CRC). Functional studies indicate that miRNAs act as tumor suppressors and oncogenes. These findings significantly extend Vogelstein's model of CRC pathogenesis and have shown great potential for miRNAs as a novel class of therapeutic targets. Several investigations have also described the ability of miRNA ex...
Source: Molecular Cancer - November 14, 2009 Category: Cancer & Oncology Authors: Ondrej SlabyMarek SvobodaJaroslav MichalekRostislav Vyzula Source Type: journals

Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell linesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Khat activated a distinct cell death pathway in sensitive leukemic cells as compared to camptothecin, involving mitochondrial damage and morphological features of autophagy. This suggests that khat should be further explored in the search for novel experimental therapeutics. (Source: Molecular Cancer)
Source: Molecular Cancer - November 13, 2009 Category: Cancer & Oncology Authors: Therese BredholtElizabeth DimbaHanne HaglandLine WergelandJorn SkavlandKjell FossanKarl TronstadAnne JohannessenOlav VintermyrBjorn Gjertsen Source Type: journals

A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although in vivo study is further required to evaluate physiological efficacies and toxicity of the combination treatment, our findings might provide a new insight into the development of novel combination therapies/chemoprevention against malignant tumors using dietary phytochemicals. (Source: Molecular Cancer)
Source: Molecular Cancer - November 12, 2009 Category: Cancer & Oncology Authors: Yoshitaka NakamuraShingo YogosawaYasuyuki IzutaniHirotsuna WatanabeEigo OtsujiToshiyuki Sakai Source Type: journals

Insulin-like growth factor binding protein-3 has dual effects on gastrointestinal stromal tumor cell viability and sensitivity to the anti-tumor effects of imatinib mesylate in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This data demonstrates that IGFBP3 has dual, opposing roles in modulating GIST cell viability and response to imatinib in vitro. These preliminary findings suggest that there may be some clinical benefits to IGFBP3 therapy in GIST patients, but further studies are needed to better characterize the functions of IGFBP3 in GIST. (Source: Molecular Cancer)
Source: Molecular Cancer - November 10, 2009 Category: Cancer & Oncology Authors: Jheri DupartJonathan TrentHo-Young LeeKenneth HessAndrew GodwinTakahiro TaguchiWei Zhang Source Type: journals

A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFkappaB activityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our data suggest that GRK5-RH inhibition of NFkappaB is a novel and effective anti-tumoral strategy and TAT-RH could be an useful tool in the fighting of cancer. (Source: Molecular Cancer)
Source: Molecular Cancer - November 9, 2009 Category: Cancer & Oncology Authors: Daniela SorrientoAlfonso CampanileGaetano SantulliEleonora LeggieroLucio PastoreBruno TrimarcoGuido Iaccarino Source Type: journals

Aurora-A down-regulates IkappaB alpha via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survivalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Taken together, our data established that Aurora-A, via activating Akt, stimulated nuclear factor-kappa B signaling pathway to promote cancer cell survival, and promised a novel combined chemotherapy targeting both Aurora-A and PI3K in cancer treatment. (Source: Molecular Cancer)
Source: Molecular Cancer - November 5, 2009 Category: Cancer & Oncology Authors: Jin-e YaoMin YanZhong GuanChao-bin PanLiang-ping XiaChuan-xing LiLi-hui WangZi-jie LongYan ZhaoMing-wei LiFei-meng ZhengJie XuDong-jun LinQuentin Liu Source Type: journals

Targeting EGFR with photodynamic therapy in combination with Erbitux enhances in vivo bladder tumor responseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The combination therapy of PDT and Erbitux effectively inhibits tumor growth and is a promising therapeutic approach in the treatment of bladder tumors. (Source: Molecular Cancer)
Source: Molecular Cancer - November 2, 2009 Category: Cancer & Oncology Authors: Ramaswamy BhuvaneswariYik Yuen GanKhee Chee SooMalini Olivo Source Type: journals

EM011 activates a survivin-dependent apoptotic program in human non-small cell lung cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These in vitro data suggest that EM011 mediates antiproliferative and proapoptotic activity in non-small cell A549 lung cancer cells by impeding cell-cycle progression and attenuating antiapoptotic signaling circuitries (viz. Bcl2, survivin). The study provides evidence for the potential usefulness of EM011 in chemotherapy of lung cancer. (Source: Molecular Cancer)
Source: Molecular Cancer - October 30, 2009 Category: Cancer & Oncology Authors: Prasanthi KarnaStar SharpClayton YatesSatya PrakashRitu Aneja Source Type: journals

Mechanisms of FUS1/TUSC2 deficiency in mesothelioma and its tumorigenic transcriptional effectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our data support immuno-therapeutic potential of TUSC2, define its targets, and underscore its importance as a transcriptional stimulator of anti-tumorigenic pathways. (Source: Molecular Cancer)
Source: Molecular Cancer - October 23, 2009 Category: Cancer & Oncology Authors: Alla IvanovaSergey IvanovLjudmila PrudkinDaisuke NonakaZhandong LiuAnne TsaoIgnacio WistubaJack RothHarvey Pass Source Type: journals

Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Differential expression of Wnt ligands in HCC cells is associated with selective activation of canonical Wnt signaling in well-differentiated, and its repression in poorly differentiated cell lines. One potential mechanism of repression involved Wnt5a, acting as an antagonist of canonical Wnt signaling. Our observations support the hypothesis that Wnt pathway is selectively activated or repressed depending on differentiation status of HCC cells. We propose that canonical and noncanonical Wnt pathways have complementary roles in HCC, where the canonical signaling contributes to tumor initiation, and noncanonica...
Source: Molecular Cancer - October 21, 2009 Category: Cancer & Oncology Authors: Haluk YuzugulluKhemais BenhajNuri OzturkSerif SenturkEmine CelikAsli ToyluNilgun TasdemirMustafa YilmazEsra ErdalKamil AkcaliNese AtabeyMehmet Ozturk Source Type: journals

Inhibition of succinate dehydrogenase dysregulates histone modifications in mammalian cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Remodelling of mitochondrial metabolism is a hallmark of cancer. Mutations in the genes encoding succinate dehydrogenase (SDH), a key Krebs cycle component, are associated with hereditary predisposition to pheochromocytoma and paraganglioma, through mechanisms which are largely unknown. Recently, the jumonji-domain histone demethylases have emerged as a novel family of 2-oxoglutarate-dependent chromatin modifiers with credible functions in tumourigenesis. Using pharmacological and siRNA methodologies we show that increased methylation of histone H3 is a general consequence of SDH loss-of-function in cultured mammalian cell...
Source: Molecular Cancer - October 21, 2009 Category: Cancer & Oncology Authors: Ana CerveraJean-Pierre BayleyPeter DevileeKenneth McCreath Source Type: journals

Mitomycin C induces bystander killing in homogeneous and heterogeneous hepatoma cellular modelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results highlight the therapeutic importance of MMC in the treatment of HCC and implicate role of membrane bound and secreted forms of FasL and TRAIL in MMC induced bystander killing. (Source: Molecular Cancer)
Source: Molecular Cancer - October 20, 2009 Category: Cancer & Oncology Authors: Ratna KumariAanchal SharmaAmrendra AjayManoj Bhat Source Type: journals

Cytokeratin 8 ectoplasmic domain binds urokinase-type plasminogen activator to breast tumor cells and modulates their adhesion, growth and invasivenessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These novel findings suggest a model in which CK8, together with uPA, plasminogen and fibronectin, constitutes a signaling platform capable of modulating cell adhesion/growth-dependent signal transduction in breast tumor cells. Anti-CK MAb, which competes for the binding site for uPA, could be used as an agent to reduce the invasive potential of breast tumor cells. (Source: Molecular Cancer)
Source: Molecular Cancer - October 20, 2009 Category: Cancer & Oncology Authors: Natasa ObermajerBojan DoljakJanko Kos Source Type: journals

Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in Acute Myeloid LeukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results suggest that the conspicuous expression of the TSG BEX2, IGSF4 and TIMP3 in MLLmu AML cell lines is the consequence of altered epigenetic properties of MLL fusion proteins. (Source: Molecular Cancer)
Source: Molecular Cancer - October 15, 2009 Category: Cancer & Oncology Authors: Sonja RohrsWilhelm DirksClaus MeyerRolf MarschalekMichaela ScherrRobert SlanyAndrew WallaceHans DrexlerHilmar Quentmeier Source Type: journals

HIPK2 modulates p53 activity towards pro-apoptotic transcriptionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results reveal a novel role for HIPK2 in activating p53 apoptotic transcription. Our results indicate that HIPK2 may regulate the balance between p53 acetylation and deacetylation, by stimulating on one hand co-recruitment of p300 and p53Lys382 on apoptotic promoters and on the other hand by inhibiting Sirt1 deacetylase activity. We attempted to reactivate p53 apoptotic transcriptional activity by rescuing both Ser46 and Lys382 modification in response to drug. Our data propose combination strategies for the treatment of tumors with dysfunctional p53 and/or HIPK2 that include classical chemotherapy with ...
Source: Molecular Cancer - October 13, 2009 Category: Cancer & Oncology Authors: Rosa PucaLavinia NardinocchiDavid GivolAda SacchiGideon RechaviGabriella D'Orazi Source Type: journals

Retraction: Blockage of transdifferentiation from fibroblast to myofibroblast in experimental ovarian cancer modelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article, Molecular Cancer 2009, 8:78 was submitted to Molecular Cancer following the acceptance of an article, Oncology Reports 2009, 22: 541-548, published in September 2009. The two articles were produced from the same data and as a result of miscommunication between authors contained extensive overlap. As such the authors would like to retract the Molecular Cancer article. The authors would like to apologise for any inconvenience this may have caused to the editorial staff and readers. (Source: Molecular Cancer)
Source: Molecular Cancer - October 13, 2009 Category: Cancer & Oncology Authors: Qin YaoXun QuQifeng YangDavid GoodShuzhen DaiBeihua KongMing Wei Source Type: journals

Identification of glucocorticoid-induced leucine zipper as a key regulator of tumor cell proliferation in epithelial ovarian cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present study is the first to identify GILZ as a molecule produced by ovarian cancer cells that promotes cell cycle progression and proliferation. Our findings clearly indicate that GILZ activates AKT, a crucial signaling molecule in tumorigenesis. GILZ thus appears as potential key molecule in EOC. (Source: Molecular Cancer)
Source: Molecular Cancer - October 7, 2009 Category: Cancer & Oncology Authors: Nassima RedjimiFrancoise GaudinCyril TouboulDominique EmilieMarc PallardyArmelle Biola-VidammentHerve FernandezSophie PrevotKarl BalabanianVeronique Machelon Source Type: journals

Limited copy number - high resolution melting (LCN-HRM) enables the detection and identification by sequencing of low level mutations in cancer biopsiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: LCN-HRM bridges the sensitivity gap between HRM and sequencing and is effective in distinguishing between artefacts and true mutations. (Source: Molecular Cancer)
Source: Molecular Cancer - October 7, 2009 Category: Cancer & Oncology Authors: Hongdo DoAlexander Dobrovic Source Type: journals

Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of actionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our findings confirm that BER suppresses the growth, migration and invasion in highly-metastatic human breast cancer cells by possibly inhibiting Akt and NF-kappaB signaling with their upstream target c-Met and downstream targets Bcl-2/Bax, osteopontin, VEGF, MMP-9 and MMP-2. BER has synergistic effects with anticancer agents trichostatin A, celecoxib, and carmofur on inhibiting the growth of MDA-MB-231 cells and reducing the ratio of Bcl-2/Bax and/or VEGF expressions in the cancer cells. These findings suggest that BER may have the wide therapeutic and/or adjuvant therapeutic application in the treatment of h...
Source: Molecular Cancer - September 30, 2009 Category: Cancer & Oncology Authors: Shan WangQian LiuYing ZhangKe LiuPengfei YuKun LiuJinling LuanHuiying DuanZhaoqiao LuFengfei WangErxi WuKazumi YagasakiGuoying Zhang Source Type: journals

Chemoresistance acquisition induces a global shift of expression of aniogenesis-associated genes and increased pro-angogenic activity in neuroblastoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A bioinformatics approach allowed to identify a relevant chemoresistance-associated shift in neuroblastoma cell biology. The chemoresistance-associated enhanced pro-angiogenic activity observed in neuroblastoma cells is relevant for tumour progression and represents a potential therapeutic target. (Source: Molecular Cancer)
Source: Molecular Cancer - September 28, 2009 Category: Cancer & Oncology Authors: Martin MichaelisDenise KlassertSusanne BarthTatyana SuhanRainer BreitlingBernd MayerNora HinschHans DoerrJaroslv CinatlJindrich Cinatl Source Type: journals

Discovery and identification of potential biomarkers of papillary thyroid carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We have identified a set of biomarkers that could discriminate PTC from non-cancer controls. An efficient strategy, including SELDI-TOF-MS analysis, HPLC purification, MALDI-TOF-MS trace and LC-MS/MS identification, has been proved successful. (Source: Molecular Cancer)
Source: Molecular Cancer - September 27, 2009 Category: Cancer & Oncology Authors: Yuxia FanLinan ShiQiuliang LiuRui DongQian ZhangShaobo YangYingzhong FanHeying YangPeng WuJiekai YuShu ZhengFuquan YangJiaxiang Wang Source Type: journals

Blockage of transdifferentiation from fibroblast to myofibroblast in experimental ovarian cancer modelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Molecular targeting of ROS and CLIC4 has the potential to develop novel therapies for ovarian cancer. (Source: Molecular Cancer)
Source: Molecular Cancer - September 26, 2009 Category: Cancer & Oncology Authors: Qin YaoXun QuQifeng YangDavid GoodShuzhen DaiBeihua KongMing Wei Source Type: journals

Selective activation of tumor growth-promoting Ca2+ channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Colon cancer-associated MS4A12 is a novel colon-specific component of store-operated Ca2+ (SOC) entry sensitizing cells for epidermal growth factor (EGF)-mediated effects on proliferation and chemotaxis. In the present study, we investigated regulation of the MS4A12 promoter to understand the mechanisms responsible for strict transcriptional restriction of this gene to the colonic epithelial cell lineage. DNA-binding assays and luciferase reporter assays showed that MS4A12 promoter activity is governed by a single CDX homeobox transcription factor binding element. RNA interference (RNAi)-mediated silencing of intestine-spe...
Source: Molecular Cancer - September 24, 2009 Category: Cancer & Oncology Authors: Michael KoslowskiOezlem TuereciChristoph HuberUgur Sahin Source Type: journals

Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results suggest that Wnt-1 is a survival factor for HCC cells, and that the blockade of Wnt-1-mediated signaling may offer a potential pathway-specific therapeutic strategy for the treatment of a subgroup of HCC that over-expresses Wnt-1. (Source: Molecular Cancer)
Source: Molecular Cancer - September 23, 2009 Category: Cancer & Oncology Authors: Wei WeiMei-Sze ChuaSusan GrepperSamuel So Source Type: journals

The rapamycin-regulated gene expression signature determines prognosis for breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Rapamycin-regulated gene expression signature predicts clinical outcome in breast cancer. This supports the central role of mTOR signaling in breast cancer biology and provides further impetus to pursue mTOR-targeted therapies for breast cancer treatment. (Source: Molecular Cancer)
Source: Molecular Cancer - September 23, 2009 Category: Cancer & Oncology Authors: Argun AkcakanatLi ZhangSpiridon TsavachidisFunda Meric-Bernstam Source Type: journals

Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our findings have potential clinical implication for EOC development and progression. (Source: Molecular Cancer)
Source: Molecular Cancer - September 17, 2009 Category: Cancer & Oncology Authors: Shahab UddinRong BuMaqbool AhmedJehad AbubakerFouad Al-DayelPrashant BaviKhawla Al-Kuraya Source Type: journals

The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Overall, these data suggest that intestinal PC5/6 is protective towards tumorigenesis, especially in mouse duodenum, and possibly in human colon. (Source: Molecular Cancer)
Source: Molecular Cancer - September 7, 2009 Category: Cancer & Oncology Authors: Xiaowei SunRachid EssalmaniNabil SeidahAnnik Prat Source Type: journals

Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival timesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: A molecular-based method for discrimination of outcome for short and long survivors is useful for future prognostic stratification at initial diagnosis, where genes and pathways associated with cell cycle / proliferation, drug resistance and metastasis could be potential targets for diagnosis and therapy. The similarities between human and canine OS makes the dog a suitable pre-clinical model for future 'novel' therapeutic approaches where the current research has provided new insights on prognostic genes, molecular pathways and mechanisms involved in OS pathogenesis and disease progression. (Source: Molecular Cancer)
Source: Molecular Cancer - September 6, 2009 Category: Cancer & Oncology Authors: Gayathri SelvarajahJolle KirpensteijnMonique van WolferenNagesha RaoHille FietenJan Mol Source Type: journals

Meta-analysis of glioblastoma multiforme versus anaplastic astrocytoma identifies robust gene markersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We have performed a meta-analysis of genome-scale mRNA expression data for 289 human malignant gliomas and have identified a list of >900 probe sets and >20 pathways that are significantly different between GBM and AA. These feature lists could be utilized to aid in diagnosis, prognosis, and grade reduction of high-grade gliomas and to identify genes that were not previously suspected of playing an important role in glioma biology. More generally, this approach suggests that combined analysis of existing data sets can reveal new insights and that the large amount of publicly available cancer data sets should b...
Source: Molecular Cancer - September 3, 2009 Category: Cancer & Oncology Authors: Jonathan DreyfussMark JohnsonPeter Park Source Type: journals

Loss of Programmed cell death 4 (Pdcd4) associates with the progression of ovarian cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Programmed cell death 4 (Pdcd4) is a novel tumour suppressor and originally identified as a neoplastic transformation inhibitor. The aim of this study was to investigate the expression, prognostic significance and potential function of Pdcd4 in ovarian cancer. Results: The expression of Pdcd4 was examined in 30 normal ovarian tissues, 16 borderline and 93 malignant ovarian tissues. A continuous down regulation of Pdcd4 expression in the sequence of normal, borderline and malignant tissues was observed. The expressions of Pdcd4 in both ovarian borderline tissues and carcinomas were significantly lower than the e...
Source: Molecular Cancer - September 2, 2009 Category: Cancer & Oncology Authors: Na WeiStephanie LiuThomas LeungKar TamXiao LiaoAnnie CheungKaren ChanHextan Ngan Source Type: journals

MicroRNA expression profiling in Imatinib-resistant Chronic Myeloid Leukemia patients without clinically significant ABL1-mutationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we have identified a group of 19 miRNAs that may predict clinical resistance to IM in patients with newly diagnosed CML. (Source: Molecular Cancer)
Source: Molecular Cancer - August 31, 2009 Category: Cancer & Oncology Authors: Edurne San Jose-EnerizJose Roman-GomezAntonio Jimenez-VelascoLeire GarateVanesa MartinLucia CordeuAmaia Vilas-ZornozaPaula Rodriguez-OteroMaria Jose CalasanzFelipe ProsperXabier Agirre Source Type: journals

Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results underscore the ability of docetaxel to induce concomitantly caspase-dependent and independent death pathways in prostate cancer cells. The results also point to LEDGF/p75 as a potential contributor to cellular resistance to docetaxel-induced lysosomal destabilization and cell death, and an attractive candidate for molecular targeting in HRPC. (Source: Molecular Cancer)
Source: Molecular Cancer - August 27, 2009 Category: Cancer & Oncology Authors: Melanie Mediavilla-VarelaFabio PachecoFrankis AlmaguelJossymar PerezEva SahakianTracy DanielsLai LeohAmelia PadillaNathan WallMichael LillyMarino De LeonCarlos Casiano Source Type: journals

STAT5 regulation of BCL10 parallels constitutive NFkappaB activation in lymphoid tumor cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest that the NFkappaB regulator BCL10 is an IL-2-independent STAT5 target gene. These findings proffer a model in which un-activated STAT5 can regulate pathways critical for lymphoid cell survival and inhibitors that disrupt STAT5 function independent of tyrosine phosphorylation may be therapeutically effective in treating certain leukemias/lymphomas. (Source: Molecular Cancer)
Source: Molecular Cancer - August 25, 2009 Category: Cancer & Oncology Authors: Zsuzsanna NagyMatthew LeBaronJeremy RossAbhisek MitraHallgeir RuiRobert Kirken Source Type: journals

Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our findings reveal that p53 increases human glioblastoma sensitivity to celecoxib. Celecoxib inhibits glioblastoma cell viability by induction of DNA damage, leading to p53-dependent G1 cell cycle arrest and p53-dependent autophagy, but not apoptosis. (Source: Molecular Cancer)
Source: Molecular Cancer - August 24, 2009 Category: Cancer & Oncology Authors: Khong Bee KangCongju ZhuSook Kwin YongQiuhan GaoMeng Cheong Wong Source Type: journals

NC2213: a novel methionine aminopeptidase 2 inhibitor in human colon cancer HT29 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report we screened various MetAP2 inhibitors and treated HT29 cells with various concentrations of compounds. We evaluated the expression of MetAP2 and pp60c-src expressions in HT29 cells. In addition we also carried out the cell proliferation and cell cycle analysis in the MetAP2 inhibitor-treated HT29 cells. The cell cycle analysis of HT29 treated with 1.0 uM of NC2213 showed an arrest in the G2 phase followed by an induction in the percentage of cells undergoing apoptosis in the sub-G1 phase. Western blot analysis revealed that the MetAP2 expression was dose-dependently decreased when the HT29 cells were treated...
Source: Molecular Cancer - August 23, 2009 Category: Cancer & Oncology Authors: Ponniah SelvakumarAshakumary LakshmikuttyammaUmashankar DasHari PatiJonathan DimmockRajendra Sharma Source Type: journals

JNK1 activation predicts the prognostic outcome of the human hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Accordingly, we believe that the H-JNK1 HCC may originate from hepatic progenitor cells and is associated with poorer prognosis. The status of JNK1 activation in HCC tissue, thus, might be a new biomarker for HCC prognosis and therapeutic targeting (Source: Molecular Cancer)
Source: Molecular Cancer - August 16, 2009 Category: Cancer & Oncology Authors: Qingshan ChangJianguo ChenKevin BeezholdVince CastranovaXianglin ShiFei Chen Source Type: journals

Vesnarinone downregulates CXCR4 expression via upregulation of Kruppel-like factor 2 in oral cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results indicate that vesnarinone downregulates CXCR4 via the upregulation of KLF2 in oral cancer. (Source: Molecular Cancer)
Source: Molecular Cancer - August 11, 2009 Category: Cancer & Oncology Authors: Daisuke UchidaTomitaro OnoueNasima-Mila BegumNobuyuki KuribayashiYoshifumi TomizukaTetsuya TamataniHirokazu NagaiYouji Miyamoto Source Type: journals

Absence of germline mono-allelic promoter hypermethylation of the CDH1 gene in gastric cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest that germline mono-allelic hypermethylation of the CDH1 promoter is not a major predisposing factor for gastric cancer. (Source: Molecular Cancer)
Source: Molecular Cancer - August 11, 2009 Category: Cancer & Oncology Authors: Hidetaka YamadaKazuya ShinmuraMasanori GotoMoriya IwaizumiHiroyuki KonnoHideki KataokaMasami YamadaTakachika OzawaToshihiro TsuneyoshiFumihiko TaniokaHaruhiko Sugimura Source Type: journals

Antisense gapmers selectively suppress individual oncogenic p73 splice isoforms and inhibit tumor growth in vivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our study demonstrates the successful development of LNA-ASOs that selectively differentiate between the closely related p73 oncoproteins, and provide new tools to further delineate their biological properties in different human malignancies and for therapeutic cancer targeting. (Source: Molecular Cancer)
Source: Molecular Cancer - August 10, 2009 Category: Cancer & Oncology Authors: Stephan EmmrichWeiwei WangKatja JohnWenzhong LiBrigitte Putzer Source Type: journals

Transcriptional activation of the Lats1 tumor suppressor gene in tumors of CUX1 transgenic miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: While inactivation of Lats1/wts in mouse and Drosophila can increase cancer incidence, results from the present study demonstrate that Lats1 is a transcriptional target of CUX1 that can be overexpressed in tumors of various tissue-types. Interestingly, two other studies documented the overexpression of LATS1 in human cervical cancers and basal-like breast cancers. We conclude that, similarly to other genes involved in mitotic checkpoint, cancer can be associated with either loss-of-function or overexpression of Lats1. (Source: Molecular Cancer)
Source: Molecular Cancer - August 4, 2009 Category: Cancer & Oncology Authors: Rania SiamRyoko HaradaChantal CadieuxRobert BattatCharles VadnaisAlain Nepveu Source Type: journals

Modulation of B-cell endoplasmic reticulum calcium homeostasis by Epstein-Barr virus Latent Membrane Protein-1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The data presented in this work indicate that EBV-induced immortalization leads to the remodelling of ER calcium homeostasis of B cells by LMP-1 that copies a previously unknown normal phenomenon taking place during antigen driven B cell activation. The functional remodelling of ER calcium homeostasis by down-regulation of SERCA3 expression constitutes a previously unknown mechanism involved in EBV-induced B cell immortalization. (Source: Molecular Cancer)
Source: Molecular Cancer - August 2, 2009 Category: Cancer & Oncology Authors: Olivier DellisAtousa ArbabianJean-Philippe BroulandTunde KovacsMartin RoweChristine ChomienneIrene JoabBela Papp Source Type: journals

Elongation Factor 1 alpha interacts with active Akt in breast cancer cells and regulates their proliferation, survival and motilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We show here that EF1alphais a pAkt-interacting protein which regulates pAkt levels. Since EF1alpha is often overexpressed in breast cancer, the consequences of EF1alpha increased levels for proliferation, survival and invasion will likely depend on the relative concentration of Akt1 and Akt2. (Source: Molecular Cancer)
Source: Molecular Cancer - August 2, 2009 Category: Cancer & Oncology Authors: Luisa PecorariOriano MarinChiara SilvestriOlivia CandiniElena RossiClara GuerzoniSara CattelaniSamanta MarianiFrancesca CorradiniGiovanna Ferrari-AmorottiLaura CortesiRita BussolariGiuseppe RaschellaMassimo FedericoBruno Calabretta Source Type: journals