Efficacy and safety of bispecific antibodies vs. immune checkpoint blockade combination therapy in cancer: a real-world comparison
Emerging tumor immunotherapy methods encompass bispecific antibodies (BSABs), immune checkpoint inhibitors (ICIs), and adoptive cell immunotherapy. BSABs belong to the antibody family that can specifically rec... (Source: Molecular Cancer)
Source: Molecular Cancer - April 16, 2024 Category: Cancer & Oncology Authors: Linyan Cheng, Lujun Chen, Yuan Shi, Weiying Gu, Weidong Ding, Xiao Zheng, Yan Liu, Jingting Jiang and Zhuojun Zheng Tags: Review Source Type: research
tRNA-derived small RNAs in human cancers: roles, mechanisms, and clinical application
Transfer RNA (tRNA)-derived small RNAs (tsRNAs) are a new type of non-coding RNAs (ncRNAs) produced by the specific cleavage of precursor or mature tRNAs. tsRNAs are involved in various basic biological proces... (Source: Molecular Cancer)
Source: Molecular Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Manli Zhou, Xiaoyun He, Jing Zhang, Cheng Mei, Baiyun Zhong and Chunlin Ou Tags: Review Source Type: research
Loss of lncRNA LINC01056 leads to sorafenib resistance in HCC
Sorafenib is a major nonsurgical option for patients with advanced hepatocellular carcinoma (HCC); however, its clinical efficacy is largely undermined by the acquisition of resistance. The aim of this study w... (Source: Molecular Cancer)
Source: Molecular Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Yau-Tuen Chan, Junyu Wu, Yuanjun Lu, Qiucheng Li, Zixin Feng, Lin Xu, Hongchao Yuan, Tingyuan Xing, Cheng Zhang, Hor-Yue Tan, Yibin Feng and Ning Wang Tags: Research Source Type: research
Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application
Tertiary lymphoid structures (TLS) are clusters of immune cells that resemble and function similarly to secondary lymphoid organs (SLOs). While TLS is generally associated with an anti-tumour immune response i... (Source: Molecular Cancer)
Source: Molecular Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Yuyuan Zhang, Mengjun Xu, Yuqing Ren, Yuhao Ba, Shutong Liu, Anning Zuo, Hui Xu, Siyuan Weng, Xinwei Han and Zaoqu Liu Tags: Review Source Type: research
Cancer immunometabolism: advent, challenges, and perspective
For decades, great strides have been made in the field of immunometabolism. A plethora of evidence ranging from basic mechanisms to clinical transformation has gradually embarked on immunometabolism to the cen... (Source: Molecular Cancer)
Source: Molecular Cancer - April 5, 2024 Category: Cancer & Oncology Authors: Qin Dang, Borui Li, Bing Jin, Zeng Ye, Xin Lou, Ting Wang, Yan Wang, Xuan Pan, Qiangsheng Hu, Zheng Li, Shunrong Ji, Chenjie Zhou, Xianjun Yu, Yi Qin and Xiaowu Xu Tags: Review Source Type: research
Functional CRISPR screens in T cells reveal new opportunities for cancer immunotherapies
T cells are fundamental components in tumour immunity and cancer immunotherapies, which have made immense strides and revolutionized cancer treatment paradigm. However, recent studies delineate the predicament... (Source: Molecular Cancer)
Source: Molecular Cancer - April 5, 2024 Category: Cancer & Oncology Authors: Minghua Xiang, Huayi Li, Yuanyuan Zhan, Ding Ma, Qinglei Gao and Yong Fang Tags: Review Source Type: research
Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF- κB p65 nuclear translocation
Cellular senescence frequently occurs during anti-cancer treatment, and persistent senescent tumor cells (STCs) unfavorably promote tumor progression through paracrine secretion of the senescence-associated se... (Source: Molecular Cancer)
Source: Molecular Cancer - April 4, 2024 Category: Cancer & Oncology Authors: Dan Zhang, Jian-Wei Zhang, Hui Xu, Xin Chen, Yu Gao, Huan-Gang Jiang, You Wang, Han Wu, Lei Yang, Wen-Bo Wang, Jing Dai, Ling Xia, Jin Peng and Fu-Xiang Zhou Tags: Research Source Type: research
Crosstalk between metabolism and cell death in tumorigenesis
It is generally recognized that tumor cells proliferate more rapidly than normal cells. Due to such an abnormally rapid proliferation rate, cancer cells constantly encounter the limits of insufficient oxygen an... (Source: Molecular Cancer)
Source: Molecular Cancer - April 4, 2024 Category: Cancer & Oncology Authors: Shichao Yang, Caden Hu, Xiaomei Chen, Yi Tang, Juanjuan Li, Hanqing Yang, Yi Yang, Binwu Ying, Xue Xiao, Shang ‑Ze Li, Li Gu and Yahui Zhu Tags: Review Source Type: research
Correction: CircPTK2 (hsa_circ_0005273) as a novel therapeutic target for metastatic colorectal cancer
(Source: Molecular Cancer)
Source: Molecular Cancer - April 2, 2024 Category: Cancer & Oncology Authors: Hongbao Yang, Xiaobo Li, Qingtao Meng, Hao Sun, Shenshen Wu, Weiwei Hu, Guilai Liu, Xianjing Li, Yong Yang and Rui Chen Tags: Correction Source Type: research
Cancer-derived exosomes as novel biomarkers in metastatic gastrointestinal cancer
Gastrointestinal cancer (GIC) is the most prevalent and highly metastatic malignant tumor and has a significant impact on mortality rates. Nevertheless, the swift advancement of contemporary technology has not... (Source: Molecular Cancer)
Source: Molecular Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Danyang Zhong, Ziyuan Wang, Zhichao Ye, Yifan Wang and Xiujun Cai Tags: Review Source Type: research
The senescence journey in cancer immunoediting
Cancer progression is continuously controlled by the immune system which can identify and destroy nascent tumor cells or inhibit metastatic spreading. However, the immune system and its deregulated activity in... (Source: Molecular Cancer)
Source: Molecular Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Alessandra Zingoni, Fabrizio Antonangeli, Silvano Sozzani, Angela Santoni, Marco Cippitelli and Alessandra Soriani Tags: Review Source Type: research
Drug resistance in ovarian cancer: from mechanism to clinical trial
Ovarian cancer is the leading cause of gynecological cancer-related death. Drug resistance is the bottleneck in ovarian cancer treatment. The increasing use of novel drugs in clinical practice poses challenges... (Source: Molecular Cancer)
Source: Molecular Cancer - March 28, 2024 Category: Cancer & Oncology Authors: Ling Wang, Xin Wang, Xueping Zhu, Lin Zhong, Qingxiu Jiang, Ya Wang, Qin Tang, Qiaoling Li, Cong Zhang, Haixia Wang and Dongling Zou Tags: Review Source Type: research
Exosomal long non-coding RNA TRPM2-AS promotes angiogenesis in gallbladder cancer through interacting with PABPC1 to activate NOTCH1 signaling pathway
Abnormal angiogenesis is crucial for gallbladder cancer (GBC) tumor growth and invasion, highlighting the importance of elucidating the mechanisms underlying this process. LncRNA (long non-coding RNA) is widel... (Source: Molecular Cancer)
Source: Molecular Cancer - March 27, 2024 Category: Cancer & Oncology Authors: Zhiqiang He, Yuhan Zhong, Parbatraj Regmi, Tianrun Lv, Wenjie Ma, Junke Wang, Fei Liu, Siqi Yang, Yanjie Zhong, Rongxing Zhou, Yanwen Jin, Nansheng Cheng, Yujun Shi, Haijie Hu and Fuyu Li Tags: Research Source Type: research
RAF inhibitor re-challenge therapy in BRAF-aberrant pan-cancers: the RE-RAFFLE study
Previous studies have shown the clinical benefit of rechallenging the RAF pathway in melanoma patients previously treated with BRAF inhibitors. 44 patients with multiple tumors harboring RAF alterations were rech... (Source: Molecular Cancer)
Source: Molecular Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Blessie Elizabeth Nelson, Jason Roszik, Jibran Ahmed, Carmelia Maria Noia Barretto, Mirella Nardo, Erick Campbell, Amber M Johnson, Sarina A. Piha-Paul, Isabella C. Glitza Oliva, Shiao-Pei Weathers, Maria Cabanillas, Milind Javle, Funda Meric-Bernstam and Tags: Correspondence Source Type: research
rs822336 binding to C/EBP β and NFIC modulates induction of PD-L1 expression and predicts anti-PD-1/PD-L1 therapy in advanced NSCLC
Efficient predictive biomarkers are needed for immune checkpoint inhibitor (ICI)-based immunotherapy in non-small cell lung cancer (NSCLC). Testing the predictive value of single nucleotide polymorphisms (SNPs... (Source: Molecular Cancer)
Source: Molecular Cancer - March 25, 2024 Category: Cancer & Oncology Authors: Giovanna Polcaro, Luigi Liguori, Valentina Manzo, Annalisa Chianese, Giuliana Donadio, Alessandro Caputo, Giosu è Scognamiglio, Federica Dell’Annunziata, Maddalena Langella, Graziamaria Corbi, Alessandro Ottaiano, Marco Cascella, Francesco Perri, Margo Tags: Research Source Type: research
