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A Reciprocal Interdependence between Nck and PI(4,5)P2 Promotes Localized N-WASp-Mediated Actin Polymerization in Living CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gonzalo M. Rivera, Dan Vasilescu, Venizelos Papayannopoulos, Wendell A. Lim, Bruce J. Mayer. Modulation of actin dynamics through the N-WASp/Arp2/3 pathway is important in cell locomotion, membrane trafficking, and pathogen infection. Here, we demonstrate that Nck is essential for actin r.... (Source: Molecular Cell)
Source: Molecular Cell - November 13, 2009 Category: Cytology Source Type: journals

Activation of the WAVE Complex by Coincident Signals Controls Actin AssemblyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Andres M. Lebensohn, Marc W. Kirschner. WAVE proteins link upstream signals to actin nucleation by activating the Arp2/3 complex and are at the core of regulatory pathways driving membrane protrusion. They are found in heteropentameric .... (Source: Molecular Cell)
Source: Molecular Cell - November 13, 2009 Category: Cytology Source Type: journals

GM1-Ganglioside Accumulation at the Mitochondria-Associated ER Membranes Links ER Stress to Ca2+-Dependent Mitochondrial ApoptosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Renata Sano, Ida Annunziata, Annette Patterson, Simon Moshiach, Elida Gomero, Joseph Opferman, Michael Forte, Alessandra d'Azzo. Mitochondria-associated ER membranes, or MAMs, define the sites of endoplasmic reticulum/mitochondria juxtaposition that control Ca2+ flux between these organelles. We found that in a m.... (Source: Molecular Cell)
Source: Molecular Cell - November 13, 2009 Category: Cytology Source Type: journals

Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial ApoptosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hyungjin Kim, Ho-Chou Tu, Decheng Ren, Osamu Takeuchi, John R. Jeffers, Gerard P. Zambetti, James J.-D. Hsieh, Emily H.-Y. Cheng. While activation of BAX/BAK by BH3-only molecules (BH3s) is essential for mitochondrial apoptosis, the underlying mechanisms remain unsettled. Here we demonstrate that BAX undergoes stepwise struc.... (Source: Molecular Cell)
Source: Molecular Cell - November 13, 2009 Category: Cytology Source Type: journals

C-Raf Inhibits MAPK Activation and Transformation by B-RafV600EEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Florian A. Karreth, Gina M. DeNicola, Stephen P. Winter, David A. Tuveson. Activating B-Raf mutations that deregulate the MAPK pathway commonly occur in cancer. Whether additional proteins modulate the enzymatic activity of oncogenic B-Raf is unknown. Here we show that t.... (Source: Molecular Cell)
Source: Molecular Cell - November 13, 2009 Category: Cytology Source Type: journals

Suppression of Cancer Cell Growth by Promoting Cyclin D1 DegradationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Jing Shan, Wenhui Zhao, Wei Gu. The cyclin D1 proto-oncoprotein is a crucial regulator in cell-cycle progression, and aberrant overexpression of cyclin D1 is linked to tumorigenesis of many different cancer types. By screening u.... (Source: Molecular Cell)
Source: Molecular Cell - November 13, 2009 Category: Cytology Source Type: journals

Ubiquitin Ligase Nedd4L Targets Activated Smad2/3 to Limit TGF-β SignalingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sheng Gao, Claudio Alarcón, Gopal Sapkota, Sadia Rahman, Pan-Yu Chen, Nina Goerner, Maria J. Macias, Hediye Erdjument-Bromage, Paul Tempst, Joan Massagué. TGF-β induces phosphorylation of the transcription factors Smad2 and Smad3 at the C terminus as well as at an interdomain linker region. TGF-β-induced linker phosphorylation marks the activated Sm.... (Source: Molecular Cell)
Source: Molecular Cell - November 13, 2009 Category: Cytology Source Type: journals

Hierarchical Rules for Argonaute Loading in DrosophilaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Benjamin Czech, Rui Zhou, Yaniv Erlich, Julius Brennecke, Richard Binari, Christians Villalta, Assaf Gordon, Norbert Perrimon, Gregory J. Hannon. Drosophila Argonaute-1 and Argonaute-2 differ in function and small RNA content. AGO2 binds to siRNAs, whereas AGO1 is almost exclusively occupied by microRNAs. MicroRNA duplexes are intrin.... (Source: Molecular Cell)
Source: Molecular Cell - November 13, 2009 Category: Cytology Source Type: journals

Distinct Mechanisms for MicroRNA Strand Selection by Drosophila ArgonautesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Katsutomo Okamura, Na Liu, Eric C. Lai. In Drosophila, miRNA strands are predominantly sorted into AGO1 to regulate seed-matched target transcripts, while their partner miRNA∗ strands are thought to be mostly degraded..... (Source: Molecular Cell)
Source: Molecular Cell - November 13, 2009 Category: Cytology Source Type: journals

Rhythmic PER Abundance Defines a Critical Nodal Point for Negative Feedback within the Circadian Clock MechanismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rongmin Chen, Aaron Schirmer, Yongjin Lee, Hyeongmin Lee, Vivek Kumar, Seung-Hee Yoo, Joseph S. Takahashi, Choogon Lee. Circadian rhythms in mammals are generated by a transcriptional negative feedback loop that is driven primarily by oscillations of PER and CRY, which inhibit their own transcriptional activators, .... (Source: Molecular Cell)
Source: Molecular Cell - November 13, 2009 Category: Cytology Source Type: journals

The Homeodomain Protein HOXB13 Regulates the Cellular Response to AndrogensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
John D. Norris, Ching-Yi Chang, Bryan M. Wittmann, Rebecca S. Kunder, Huaxia Cui, Daju Fan, James D. Joseph, Donald P. McDonnell. HOXB13 is a member of the homeodomain family of sequence-specific transcription factors and, together with the androgen receptor (AR), plays a critical role in the normal development of the prosta.... (Source: Molecular Cell)
Source: Molecular Cell - November 13, 2009 Category: Cytology Source Type: journals

Regulation of Meiotic Recombination via Mek1-Mediated Rad54 PhosphorylationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hengyao Niu, Lihong Wan, Valeria Busygina, YoungHo Kwon, Jasmina A. Allen, Xue Li, Ryan C. Kunz, Kazuishi Kubota, Beatrice Wang, Patrick Sung, Kevan M. Shokat, Steven P. Gygi, Nancy M. Hollingsworth. A preference for homologs over sister chromatids in homologous recombination is a fundamental difference in meiotic versus mitotic cells. In budding yeast, the bias for interhomolog recombination .... (Source: Molecular Cell)
Source: Molecular Cell - November 13, 2009 Category: Cytology Source Type: journals

GAMT, a p53-Inducible Modulator of Apoptosis, Is Critical for the Adaptive Response to Nutrient StressEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Takao Ide, Lauren Brown-Endres, Kiki Chu, Pat P. Ongusaha, Takao Ohtsuka, Wafik S. El-Deiry, Stuart A. Aaronson, Sam W. Lee. The p53 tumor suppressor protein has a well-established role in cell-fate decision-making processes. However, recent discoveries indicate that p53 has a non-tumor-suppressive role. Here we identif.... (Source: Molecular Cell)
Source: Molecular Cell - November 13, 2009 Category: Cytology Source Type: journals

A Nuclear Poly(ADP-Ribose)-Dependent Signalosome Confers DNA Damage-Induced IκB Kinase ActivationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Michael Stilmann, Michael Hinz, Seda Çöl Arslan, Anja Zimmer, Valérie Schreiber, Claus Scheidereit. Upon genotoxic stresses, cells activate IκB kinases (IKKs) and the transcription factor NF-κB to modulate apoptotic responses. The SUMO-1 ligase PIASy and the kinase ataxia talengiectasia mutated .... (Source: Molecular Cell)
Source: Molecular Cell - November 13, 2009 Category: Cytology Source Type: journals

Emerging Role for Members of the Bcl-2 Family in Mitochondrial MorphogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Arnaud Autret, Seamus J. Martin. Bcl-2 family proteins regulate apoptosis by controlling the release of mitochondrial cytochrome c via the Bax/Bak channel. However, recent studies have also implicated several members of th.... (Source: Molecular Cell)
Source: Molecular Cell - November 13, 2009 Category: Cytology Source Type: journals

BAX and BAK Caught in the ActEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Yong Yao, Francesca M. Marassi. In this issue of Molecular Cell, Kim et al. (2009) describe the steps involved in the direct activation of the proapoptotic proteins BAX and BAK by their BH3-only partners, resolving the co.... (Source: Molecular Cell)
Source: Molecular Cell - November 13, 2009 Category: Cytology Source Type: journals

p53 and Metabolism: The GAMT ConnectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Yan Zhu, Carol Prives. In this issue of Molecular Cell, Ide et al. (2009) have identified the enzyme guanidinoacetate methyltransferase (GAMT) that regulates creatine metabolism as a p53 target involved in apopto.... (Source: Molecular Cell)
Source: Molecular Cell - November 13, 2009 Category: Cytology Source Type: journals

A PAR-SUMOnious Mechanism of NEMO ActivationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Kevin McCool, Shigeki Miyamoto. In this issue of Molecular Cell, Stilmann et al. (2009) demonstrate a new mode of prosurvival NF-κB activation through the formation of a PARP-1-poly(ADP-ribose) signaling scaffold in respo.... (Source: Molecular Cell)
Source: Molecular Cell - November 13, 2009 Category: Cytology Source Type: journals

Maturation of MicroRNA Is Hormonally Regulated by a Nuclear ReceptorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Kaoru Yamagata, Sally Fujiyama, Saya Ito, Takashi Ueda, Takuya Murata, Masanori Naitou, Ken-ichi Takeyama, Yasuhiro Minami, Bert W. O'Malley, Shigeaki Kato. Steroid hormones and their cognate nuclear receptors exert a wide spectrum of biological actions through regulation of transcriptional and posttranscriptional processes. However, the underlying mo.... (Source: Molecular Cell)
Source: Molecular Cell - October 23, 2009 Category: Cytology Source Type: journals

Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling OutcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chunaram Choudhary, Jesper V. Olsen, Christian Brandts, Jürgen Cox, Pavankumar N.G. Reddy, Frank D. Böhmer, Volker Gerke, Dirk-E. Schmidt-Arras, Wolfgang E. Berdel, Carsten Müller-Tidow, Matthias Mann, Hubert Serve. Inappropriate activation of oncogenic kinases at intracellular locations is frequently observed in human cancers, but its effects on global signaling are incompletely understood. Here, we show tha.... (Source: Molecular Cell)
Source: Molecular Cell - October 23, 2009 Category: Cytology Source Type: journals

Key Role of Ubc5 and Lysine-63 Polyubiquitination in Viral Activation of IRF3Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Wenwen Zeng, Ming Xu, Siqi Liu, Lijun Sun, Zhijian J. Chen. The mitochondrial antiviral signaling protein (MAVS; also known as IPS-1, VISA, and CARDIF) is essential for innate immune response against RNA viruses. MAVS transduces signals from the cytosolic .... (Source: Molecular Cell)
Source: Molecular Cell - October 23, 2009 Category: Cytology Source Type: journals

A Ubiquitin Replacement Strategy in Human Cells Reveals Distinct Mechanisms of IKK Activation by TNFα and IL-1βEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ming Xu, Brian Skaug, Wenwen Zeng, Zhijian J. Chen. Lysine-63 (K63)-linked polyubiquitination has emerged as a mechanism regulating diverse cellular functions, including activation of the protein kinase IKK in the NF-κB pathways. However, genetic e.... (Source: Molecular Cell)
Source: Molecular Cell - October 23, 2009 Category: Cytology Source Type: journals

Two Mammalian MOF Complexes Regulate Transcription Activation by Distinct MechanismsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Xiangzhi Li, Lipeng Wu, Callie Ann Sprunger Corsa, Steve Kunkel, Yali Dou. In mammals, MYST family histone acetyltransferase MOF plays important roles in transcription activation by acetylating histone H4 on K16, a prevalent mark associated with chromatin decondensation,.... (Source: Molecular Cell)
Source: Molecular Cell - October 23, 2009 Category: Cytology Source Type: journals

HIV-1 mRNA 3′ End Processing Is Distinctively Regulated by eIF3f, CDK11, and Splice Factor 9G8Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Susana T. Valente, Greg M. Gilmartin, Krishnan Venkatarama, Gloria Arriagada, Stephen P. Goff. A genetic screen previously identified the N-terminal 91 amino acids of the eukaryotic initiation factor 3 subunit f (N91-eIF3f) as a potent inhibitor of HIV-1 replication. Overexpression of N91-e.... (Source: Molecular Cell)
Source: Molecular Cell - October 23, 2009 Category: Cytology Source Type: journals

FLASH, a Proapoptotic Protein Involved in Activation of Caspase-8, Is Essential for 3′ End Processing of Histone Pre-mRNAsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Xiao-cui Yang, Brandon D. Burch, Yan Yan, William F. Marzluff, Zbigniew Dominski. 3′ end processing of histone pre-mRNA requires U7 snRNP, which binds downstream of the cleavage site and recruits the endonuclease CPSF-73. U7 snRNP contains a unique Sm ring in which the canonica.... (Source: Molecular Cell)
Source: Molecular Cell - October 23, 2009 Category: Cytology Source Type: journals

The Ess1 Prolyl Isomerase Is Required for Transcription Termination of Small Noncoding RNAs via the Nrd1 PathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Navjot Singh, Zhuo Ma, Trent Gemmill, Xiaoyun Wu, Holland DeFiglio, Anne Rossettini, Christina Rabeler, Olivia Beane, Randall H. Morse, Michael J. Palumbo, Steven D. Hanes. Genome-wide studies have identified abundant small, noncoding RNAs, including small nuclear RNAs, small nucleolar RNAs (snoRNAs), cryptic unstable transcripts (CUTs), and upstream regulatory RNAs .... (Source: Molecular Cell)
Source: Molecular Cell - October 23, 2009 Category: Cytology Source Type: journals

Biased Chromatin Signatures around Polyadenylation Sites and ExonsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Noah Spies, Cydney B. Nielsen, Richard A. Padgett, Christopher B. Burge. Core RNA-processing reactions in eukaryotic cells occur cotranscriptionally in a chromatin context, but the relationship between chromatin structure and pre-mRNA processing is poorly understood. W.... (Source: Molecular Cell)
Source: Molecular Cell - October 23, 2009 Category: Cytology Source Type: journals

Epigenetic Silencing of the RASSF1A Tumor Suppressor Gene through HOXB3-Mediated Induction of DNMT3B ExpressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rajendra Kumar Palakurthy, Narendra Wajapeyee, Manas K. Santra, Claude Gazin, Ling Lin, Stephane Gobeil, Michael R. Green. The RASSF1A tumor suppressor gene is epigenetically silenced in a variety of cancers. Here, we perform a genome-wide human shRNA screen and find that epigenetic silencing of RASSF1A .... (Source: Molecular Cell)
Source: Molecular Cell - October 23, 2009 Category: Cytology Source Type: journals

Conserved Telomere Maintenance Component 1 Interacts with STN1 and Maintains Chromosome Ends in Higher EukaryotesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Yulia V. Surovtseva, Dmitri Churikov, Kara A. Boltz, Xiangyu Song, Jonathan C. Lamb, Ross Warrington, Katherine Leehy, Michelle Heacock, Carolyn M. Price, Dorothy E. Shippen. Orthologs of the yeast telomere protein Stn1 are present in plants, but other components of the Cdc13/Stn1/Ten1 (CST) complex have only been found in fungi. Here we report the identification of co.... (Source: Molecular Cell)
Source: Molecular Cell - October 23, 2009 Category: Cytology Source Type: journals

RPA-like Mammalian Ctc1-Stn1-Ten1 Complex Binds to Single-Stranded DNA and Protects Telomeres Independently of the Pot1 PathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Yasuyuki Miyake, Mirai Nakamura, Akira Nabetani, Shintaro Shimamura, Miki Tamura, Shin Yonehara, Motoki Saito, Fuyuki Ishikawa. Budding yeast Cdc13, Stn1, and Ten1 form the CST complex to protect telomeres from lethal DNA degradation. It remains unknown whether similar complexes are conserved in higher eukaryotes or not. H.... (Source: Molecular Cell)
Source: Molecular Cell - October 23, 2009 Category: Cytology Source Type: journals

“Cotranscriptionality”: The Transcription Elongation Complex as a Nexus for Nuclear TransactionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Roberto Perales, David Bentley. Much of the complex process of RNP biogenesis takes place at the gene cotranscriptionally. The target for RNA binding and processing factors is, therefore, not a solitary RNA molecule but, rather,.... (Source: Molecular Cell)
Source: Molecular Cell - October 23, 2009 Category: Cytology Source Type: journals

Targeting HSP70 for Cancer TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lorenzo Galluzzi, Fabrizio Giordanetto, Guido Kroemer. In a recent issue of Molecular Cell, Leu et al. (2009) demonstrate that a chemical inhibitor of HSP70 exerts prominent tumor-selective cytotoxic effects, thereby lending further support to .... (Source: Molecular Cell)
Source: Molecular Cell - October 23, 2009 Category: Cytology Source Type: journals

hMOF, a KAT(8) with Many LivesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hestia S. Mellert, Steven B. McMahon. Dynamic lysine acetylation regulates proteins involved in diverse cellular processes, with individual enzymes often acetylating multiple substrates. Here, Li et al. (2009) show that the substrate .... (Source: Molecular Cell)
Source: Molecular Cell - October 23, 2009 Category: Cytology Source Type: journals

Hormonal Regulation of MicroRNA BiogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sara Macias, Gracjan Michlewski, Javier F. Cáceres. In this issue of Molecular Cell, Yamagata et al. (2009) provide insight into the complex posttranscriptional regulation of miRNA biogenesis by showing that the processing of a subset of miR.... (Source: Molecular Cell)
Source: Molecular Cell - October 23, 2009 Category: Cytology Source Type: journals

22G-RNAs in Transposon Silencing and Centromere FunctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mario Halic, Danesh Moazed. Three recent papers (Gu et al., 2009; Claycomb et al., 2009; van Wolfswinkel et al., 2009) provide evidence that links a new class of small RNAs and Argonaute-associated complexes to centromere fu.... (Source: Molecular Cell)
Source: Molecular Cell - October 23, 2009 Category: Cytology Source Type: journals

The CST Complex and Telomere Maintenance: The Exception Becomes the RuleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Raymund J. Wellinger. Telomeres are bound and stabilized by two complexes—CST and shelterin—thought to be species specific and virtually unrelated. In this issue of Molecular Cell, Miyake et al. (2009) and Surov.... (Source: Molecular Cell)
Source: Molecular Cell - October 23, 2009 Category: Cytology Source Type: journals

How To Give a Good TalkEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Uri Alon. We depend on talks to communicate our work, and we spend much of our time as audience members in talks. However, few scientists are taught the well-established principles of giving good talks. Her.... (Source: Molecular Cell)
Source: Molecular Cell - October 23, 2009 Category: Cytology Source Type: journals

A Method for Genetically Installing Site-Specific Acetylation in Recombinant Histones Defines the Effects of H3 K56 AcetylationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Heinz Neumann, Susan M. Hancock, Ruth Buning, Andrew Routh, Lynda Chapman, Joanna Somers, Tom Owen-Hughes, John van Noort, Daniela Rhodes, Jason W. Chin. Lysine acetylation of histones defines the epigenetic status of human embryonic stem cells and orchestrates DNA replication, chromosome condensation, transcription, telomeric silencing, and DNA re.... (Source: Molecular Cell)
Source: Molecular Cell - October 9, 2009 Category: Cytology Source Type: journals

The eIF3 Interactome Reveals the Translasome, a Supercomplex Linking Protein Synthesis and Degradation MachineriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Zhe Sha, Laurence M. Brill, Rodrigo Cabrera, Oded Kleifeld, Judith S. Scheliga, Michael H. Glickman, Eric C. Chang, Dieter A. Wolf. eIF3 promotes translation initiation, but relatively little is known about its full range of activities in the cell. Here, we employed affinity purification and highly sensitive LC-MS/MS to deciph.... (Source: Molecular Cell)
Source: Molecular Cell - October 9, 2009 Category: Cytology Source Type: journals

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dung-Fang Lee, Hsu-Ping Kuo, Mo Liu, Chao-Kai Chou, Weiya Xia, Yi Du, Jia Shen, Chun-Te Chen, Longfei Huo, Ming-Chuan Hsu, Chia-Wei Li, Qingqing Ding, Tsai-Lien Liao, Chien-Chen Lai, Ann-Chi Lin, Ya-Hui Chang, Shih-Feng Tsai, Long-Yuan Li, Mien-Chie Hung. IκB kinase β (IKKβ) is involved in tumor development and progression through activation of the nuclear factor (NF)-κB pathway. However, the molecular mechanism that regulates IKKβ degradation rema.... (Source: Molecular Cell)
Source: Molecular Cell - October 9, 2009 Category: Cytology Source Type: journals

An SOS Inhibitor that Binds to Free RecA Protein: The PsiB ProteinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vessela Petrova, Sindhu Chitteni-Pattu, Julia C. Drees, Ross B. Inman, Michael M. Cox. The process of bacterial conjugation involves the transfer of a conjugative plasmid as a single strand. The potentially deleterious SOS response, which is normally triggered by the appearance of s.... (Source: Molecular Cell)
Source: Molecular Cell - October 9, 2009 Category: Cytology Source Type: journals

BBAP Monoubiquitylates Histone H4 at Lysine 91 and Selectively Modulates the DNA Damage ResponseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Qingsheng Yan, Shilpee Dutt, Rong Xu, Katherine Graves, Przemyslaw Juszczynski, John P. Manis, Margaret A. Shipp. Although the BBAP E3 ligase and its binding partner BAL are overexpressed in chemotherapy-resistant lymphomas, the role of these proteins in DNA damage responses remains undefined. Because BAL pro.... (Source: Molecular Cell)
Source: Molecular Cell - October 9, 2009 Category: Cytology Source Type: journals

Yeast RNase III Triggers Polyadenylation-Independent Transcription TerminationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ghada Ghazal, Jules Gagnon, Pierre-Étienne Jacques, Josette-Renée Landry, François Robert, Sherif Abou Elela. Transcription termination of messenger RNA (mRNA) is normally achieved by polyadenylation followed by Rat1p-dependent 5′-3′ exoribonuleolytic degradation of the downstream transcript. Here we show.... (Source: Molecular Cell)
Source: Molecular Cell - October 9, 2009 Category: Cytology Source Type: journals

Fail-Safe Transcriptional Termination for Protein-Coding Genes in S. cerevisiaeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ana G. Rondón, Hannah E. Mischo, Junya Kawauchi, Nick J. Proudfoot. Transcription termination of RNA polymerase II (Pol II) on protein-coding genes in S. cerevisiae relies on pA site recognition by 3′ end processing factors. Here we demonstrate the existenc.... (Source: Molecular Cell)
Source: Molecular Cell - October 9, 2009 Category: Cytology Source Type: journals

SKIP Interacts with c-Myc and Menin to Promote HIV-1 Tat TransactivationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vanessa Brès, Tomonori Yoshida, Loni Pickle, Katherine A. Jones. The Ski-interacting protein SKIP/SNW1 associates with the P-TEFb/CDK9 elongation factor and coactivates inducible genes, including HIV-1. We show here that SKIP also associates with c-Myc and Meni.... (Source: Molecular Cell)
Source: Molecular Cell - October 9, 2009 Category: Cytology Source Type: journals

Mir-214-Dependent Regulation of the Polycomb Protein Ezh2 in Skeletal Muscle and Embryonic Stem CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aster H. Juan, Roshan M. Kumar, Joseph G. Marx, Richard A. Young, Vittorio Sartorelli. Polycomb group (PcG) proteins exert essential functions in the most disparate biological processes. The contribution of PcG proteins to cell commitment and differentiation relates to their ability.... (Source: Molecular Cell)
Source: Molecular Cell - October 9, 2009 Category: Cytology Source Type: journals

α4 Is an Essential Regulator of PP2A Phosphatase ActivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mei Kong, Dara Ditsworth, Tullia Lindsten, Craig B. Thompson. The activity and specificity of serine/threonine phosphatases are governed largely by their associated proteins. α4 is an evolutionarily conserved noncatalytic subunit for PP2A-like phosphatases. .... (Source: Molecular Cell)
Source: Molecular Cell - October 9, 2009 Category: Cytology Source Type: journals

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin LigasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Min Zhuang, Matthew F. Calabrese, Jiang Liu, M. Brett Waddell, Amanda Nourse, Michal Hammel, Darcie J. Miller, Helen Walden, David M. Duda, Steven N. Seyedin, Timothy Hoggard, J. Wade Harper, Kevin P. White, Brenda A. Schulman. In the largest E3 ligase subfamily, Cul3 binds a BTB domain, and an associated protein-interaction domain such as MATH recruits substrates for ubiquitination. Here, we present biochemical and stru.... (Source: Molecular Cell)
Source: Molecular Cell - October 9, 2009 Category: Cytology Source Type: journals

The Otubain YOD1 Is a Deubiquitinating Enzyme that Associates with p97 to Facilitate Protein Dislocation from the EREmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Robert Ernst, Britta Mueller, Hidde L. Ploegh, Christian Schlieker. YOD1 is a highly conserved deubiquitinating enzyme of the ovarian tumor (otubain) family, whose function has yet to be assigned in mammalian cells. YOD1 is a constituent of a multiprotein complex .... (Source: Molecular Cell)
Source: Molecular Cell - October 9, 2009 Category: Cytology Source Type: journals

A Small Molecule Inhibitor of Inducible Heat Shock Protein 70Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
J. I-Ju Leu, Julia Pimkina, Amanda Frank, Maureen E. Murphy, Donna L. George. The multifunctional, stress-inducible molecular chaperone HSP70 has important roles in aiding protein folding and maintaining protein homeostasis. HSP70 expression is elevated in many cancers, con.... (Source: Molecular Cell)
Source: Molecular Cell - October 9, 2009 Category: Cytology Source Type: journals