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Imaging of Gadolinium Spatial Distribution in Tumor Tissue by Laser Ablation Inductively Coupled Plasma Mass Spectrometryemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  We have demonstrated, in a novel manner, the use of LA–ICP–MS for the spatial detection of Gd in tumor tissue. LA–ICP–MS is valuable in providing spatio-specific information of MRI contrast agents and more importantly Gd in tumor tissue. Content Type Journal ArticleCategory Brief ArticleDOI 10.1007/s11307-009-0282-4Authors Nazila Kamaly, Hammersmith Hospital, Imperial College London Imaging Sciences Department, Metabolic and Molecular Imaging Group, MRC Clinical Sciences Center London W12 0NN UKJohn A. Pugh, University of Sheffield Department of Chemistry, Center for Analytical Scie...
Source: Molecular Imaging and Biology - November 17, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

High Impact of 18F-FDG-PET on Management and Prognostic Stratification of Newly Diagnosed Small Cell Lung Canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  PET had a major impact on stage classification, management, and prognostic stratification of newly diagnosed SCLC. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0295-zAuthors Arun Azad, Ludwig Institute Oncology Unit, Austin Health Heidelberg AustraliaFiona Chionh, Ludwig Institute Oncology Unit, Austin Health Heidelberg AustraliaAndrew M. Scott, Centre for Positron Emission Tomography, Austin Health Melbourne AustraliaSzeting T. Lee, Centre for Positron Emission Tomography, Austin Health Melbourne AustraliaSam U. Berlangieri, Centre for Positron Emission Tomogra...
Source: Molecular Imaging and Biology - November 17, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

High-Affinity αvβ3 Integrin Targeted Optical Probe as a New Imaging Biomarker for Early Atherosclerosis: Initial Studies in Watanabe Rabbitsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  This high-affinity ITOP identifies the site and extent of αvβ3 expression and correlates with adventitial thickness. Recent evidence associates αvβ3 expression with the inflammatory process in early vulnerable plaque, making this compound a promising potential biomarker for early atherosclerotic disease. Content Type Journal ArticleCategory Brief ArticleDOI 10.1007/s11307-009-0242-zAuthors Julie Heroux, National Institute of Diabetes Digestive and Kidney Diseases Laboratory of Integrative Cardiovascular Imaging Science Bethesda MD 20892 USAAhmed M. Gharib, National Institute of Diabete...
Source: Molecular Imaging and Biology - November 7, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Introduction to the Proceedings of the 2nd World Molecular Imaging Congressemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s11307-009-0253-9 Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - November 3, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Proceedings of the 2009 World Molecular Imaging Congress Montreal, Canada, September 23–26email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s11307-009-0251-y Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - November 3, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Author Indexemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s11307-009-0252-x Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - November 3, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

In Vivo Imaging of Sentinel Nodes Using Fluorescent Silica Nanoparticles in Living Miceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  Our data provide strong evidence that functionalized silica nanoparticles has a promising potential as organic lymphatic tracer in biomedical imaging such as pre- and intraoperative surgical guidance. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0262-8Authors Yong Hyun Jeon, Seoul National University College of Medicine Department of Nuclear Medicine 28 Yongon-dong, Jongno-gu Seoul 110-744 South KoreaYoung-Hwa Kim, Seoul National University Department of Laboratory of Molecular Imaging and Therapy of Cancer Research Institute Seoul South KoreaKihwan Choi, Seoul...
Source: Molecular Imaging and Biology - October 15, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Diagnostic Performance of FDG-PET, MRI, and Plain Film Radiography (PFR) for the Diagnosis of Osteomyelitis in the Diabetic Footemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  FDG-PET is a highly specific imaging modality for the diagnosis of osteomyelitis in diabetic foot and, therefore, should be considered to be a useful complimentary imaging modality with MRI. In the setting where MRI is contraindicated, the high sensitivity and specificity of FDG-PET justifies its use after a negative or inconclusive PFR to aid an accurate diagnosis. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0268-2Authors Asad Nawaz, Department of Radiology, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania Division of...
Source: Molecular Imaging and Biology - October 9, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

On the Added Value of Baseline FDG-PET in Malignant Lymphomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  Without any other clinical information, pretreatment PET facilitates changes the interpretation of a posttreatment PET in a third of the patients, resulting in both upgrading and downgrading of the posttreatment situation of a malignant lymphoma patient. If these results are confirmed for PET–computed tomography systems, they favor the addition of baseline PET to the current work-up of patients with malignant lymphoma. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0259-3Authors Henriette Quarles van Ufford, University Medical Center Utrecht Radiology Utrecht...
Source: Molecular Imaging and Biology - October 7, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Two-Step In Vivo Tumor Targeting by Biotin-Conjugated Antibodies and Superparamagnetic Nanoparticles Assessed by Magnetic Resonance Imaging at 1.5 Temail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  MRI at 1.5 T can detect tumors by a two-step in vivo biotin-based protocol, which may allow the targeting of any cell surface antigen. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0264-6Authors Gabriella Baio, National Cancer Institute Department of Diagnostic Imaging, IST Largo Rosanna Benzi 10 16132 Genoa ItalyMarina Fabbi, National Cancer Institute Unit of Immunological Therapy, IST Largo Rosanna Benzi 10 16132 Genoa ItalySandra Salvi, National Cancer Institute Department of Pathology, IST Largo Rosanna Benzi 10 16132 Genoa ItalyDaniela de Totero, Nation...
Source: Molecular Imaging and Biology - October 6, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Detection of Experimentally Induced Pulmonary Granuloma Inflammation in Monocyte Chemoattractant Protein-1 Reporter Miceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  By using a pulmonary granuloma model, we showed that EGFP transgene reporter expression in MCP-1-EGFP mouse was correlated to the endogenous MCP-1 induction. The establishment of this mouse model will provide a valuable tool for monitoring the activation of monocytes/macrophages and facilitate the studies on the roles of MCP-1 gene in various inflammatory diseases. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0261-9Authors Subbiah Rajasekaran, National Health Research Institutes Division of Medical Engineering Research Zhunan Town Miaoli County Taiwan Republi...
Source: Molecular Imaging and Biology - October 6, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Quantitative Assessment of the Hepatic Metabolic Volume Product in Patients with Diffuse Hepatic Steatosis and Normal Controls Through Use of FDG-PET and MR Imaging: A Novel Conceptemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  The increase in HMVP is the result of increased hepatic metabolic activity likely related to the diffuse hepatic steatosis. The active inflammatory process related to the diffuse hepatic steatosis is the probable explanation for the increase in hepatic metabolic activity on FDG-PET study. Content Type Journal ArticleCategory Brief ArticleDOI 10.1007/s11307-009-0258-4Authors Gonca G. Bural, Hospital of the University of Pennsylvania Division of Nuclear Medicine, Department of Radiology 3400 Spruce Street, 110 Donner Bldg. Philadelphia PA 19104 USADrew A. Torigian, Hospital of the University ...
Source: Molecular Imaging and Biology - October 6, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

A Novel Fluorescent Imaging Agent for Diffuse Optical Tomography of the Breast: First Clinical Experience in Patientsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Lowest doses of Omocianine performed best in lesion detection; DOT using a low-dose fluorescent agent is feasible and safe for breast cancer visualization in patients. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0269-1Authors Stephanie van de Ven, University Medical Center Utrecht Department of Radiology Utrecht The NetherlandsAndrea Wiethoff, Philips Healthcare Best The NetherlandsTim Nielsen, Philips Research Europe Eindhoven The NetherlandsBernhard Brendel, Philips Research Europe Eindhoven The NetherlandsMarjolein van der Voort, Philips Research Europe Ph...
Source: Molecular Imaging and Biology - October 2, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

68Ga-Chloride PET Reveals Human Pancreatic Adenocarcinoma Xenografts in Rats—Comparison with FDGemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions   68Ga-chloride delineated subcutaneously implanted pancreatic adenocarcinoma xenografts by PET, but the uptake was lower than FDG. Further studies to clarify the value of 68Ga-chloride for PET imaging of tumors are warranted. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0267-3Authors Tiina Ujula, Turku University Hospital Turku PET Centre 20521 Turku FinlandSatu Salomäki, Turku University Hospital Turku PET Centre 20521 Turku FinlandAnu Autio, Turku University Hospital Turku PET Centre 20521 Turku FinlandPauliina Luoto, Turku University Hospital Turku PET Ce...
Source: Molecular Imaging and Biology - October 2, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

COMT Val158Met Genotype Does Not Alter Cortical or Striatal Dopamine D2 Receptor Availability In Vivoemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  COMT genotype is not related with alterations in baseline D2 receptor availability in vivo in the cortex or the striatum. This information is useful for the interpretation of genetic studies on COMT in neuropsychiatry. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0257-5Authors Mika M. Hirvonen, University of Turku Department of Pharmacology, Drug Development and Therapeutics 20014 Turku FinlandKjell Någren, Turku University Hospital Turku PET Centre 20014 Turku FinlandJuha O. Rinne, Turku University Hospital Turku PET Centre 20014 Turku FinlandUllamari Pesonen...
Source: Molecular Imaging and Biology - September 30, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

In Vivo Fluorescence Imaging is Well-Suited for the Monitoring of Adenovirus Directed Transgene Expression in Living Organismsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  These findings demonstrate that in vivo fluorescence imaging provides functional data indicating the approximate location, magnitude, and duration of AdEGFP expression. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0260-xAuthors Sevim Kahraman, Akdeniz University Human Gene Therapy Division, Faculty of Medicine Antalya 07070 TurkeyErcument Dirice, Akdeniz University Human Gene Therapy Division, Faculty of Medicine Antalya 07070 TurkeyAhter Dilsad Sanlioglu, Akdeniz University Human Gene Therapy Division, Faculty of Medicine Antalya 07070 TurkeyBurcak Yoldas, Akd...
Source: Molecular Imaging and Biology - September 30, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

[11C]Gefitinib ([11C]Iressa): Radiosynthesis, In Vitro Uptake, and In Vivo Imaging of Intact Murine Fibrosarcomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  These results demonstrated the promising potential of [11C]gefitinib to serve as a PET ligand for in vivo imaging of NFSa-bearing mice. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0265-5Authors Ming-Rong Zhang, National Institute of Radiological Sciences Department of Molecular Probes, Molecular Imaging Center 4-9-1 Anagawa, Inage-ku Chiba JapanKatsushi Kumata, National Institute of Radiological Sciences Department of Molecular Probes, Molecular Imaging Center 4-9-1 Anagawa, Inage-ku Chiba JapanAkiko Hatori, National Institute of Radiological Sciences Departmen...
Source: Molecular Imaging and Biology - September 29, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Development and Validation of a Monte Carlo Simulation Tool for Multi-Pinhole SPECTemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  The new method is useful for studying MPH collimator designs, data acquisition protocols, image reconstructions, and compensation techniques. It also has great potential to be applied for modeling the collimator-detector response with penetration and scatter effects for MPH in the quantitative reconstruction method. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0263-7Authors Greta S. P. Mok, The Chinese University of Hong Kong Department of Diagnostic Radiology and Organ Imaging Shatin N.T. Hong KongYong Du, Johns Hopkins University Division of Medical Imaging...
Source: Molecular Imaging and Biology - September 25, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

64Cu-Labeled Affibody Molecules for Imaging of HER2 Expressing Tumorsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This study demonstrates that 64Cu-labeled ZHER2:477 is a promising targeted molecular probe for imaging HER2 receptor expression in living mice. Further work is needed to improve the excretion properties, hence dosimetry and imaging efficacy, of the radiometal-based probe. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0256-6Authors Zhen Cheng, Stanford University Molecular Imaging Program at Stanford (MIPS), Departments of Radiology and Bioengineering, Bio-X Program California CA 94305-5344 USAOmayra Padilla De Jesus, Global Research Center General Electric Company Niskayuna NY 12309...
Source: Molecular Imaging and Biology - September 25, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Predicting Early Chemotherapy Response with Technetium-99m Methoxyisobutylisonitrile SPECT/CT in Advanced Non-Small Cell Lung Canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Our series demonstrated solid, negative correlations between prechemotherapy 99mTc-MIBI uptake and tumor size change measured by CT for advanced NSCLC, particularly with C mean and 1D change. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0250-zAuthors Tzu-I J. Yang, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital Department of Radiotherapy Plesmanlaan 121 1066 CX Amsterdam The NetherlandsTjeerd S. Aukema, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital Department of Nuclear Medicine Amsterdam The NetherlandsHarm van Tintere...
Source: Molecular Imaging and Biology - September 15, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Letter to the Editoremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s11307-009-0254-8Authors Victor H. Gerbaudo, Harvard Medical School Division of Nuclear Medicine and Molecular Imaging, Brigham & Women’s Hospital Boston MA USAScott Britz-Cunningham, Harvard Medical School Division of Nuclear Medicine and Molecular Imaging, Brigham & Women’s Hospital Boston MA USA Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - September 3, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Letter to the Editoremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s11307-009-0255-7Authors Sze Ting Lee, Austin Hospital Nuclear Medicine Physician, Centre for PET, Austin Health Level 1, Harold Stokes Building, Burgundy Street Heidelberg Victoria 3084 Australia Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - August 26, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Surface Feature-Guided Mapping of Cerebral Metabolic Changes in Cognitively Normal and Mildly Impaired Elderlyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Using 3-D surface-based MR-guided FDG-PET mapping, significant metabolic changes were seen in five posterior and the left lateral frontal regions. The changes were more pronounced for the declining relative to the cognitively stable group. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0247-7Authors Liana G. Apostolova, David Geffen School of Medicine, UCLA Department of Neurology 10911 Weyburn Ave, 2nd floor Los Angeles CA 90095 USAPaul M. Thompson, David Geffen School of Medicine, UCLA Department of Neurology 10911 Weyburn Ave, 2nd floor Los Angeles CA 90095 U...
Source: Molecular Imaging and Biology - July 28, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Dynamic Contrast-Enhanced Folate-Receptor-Targeted MR Imaging Using a Gd-loaded PEG-Dendrimer–Folate Conjugate in a Mouse Xenograft Tumor Modelemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  We have demonstrated the targeting ability of PEG-G3-(Gd-DTPA)11-(folate)5 in vitro and in vivo. A 17% cut-off point for a 30-min washout percentage can be a useful parameter for the diagnosis of FR-positive tumors. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0248-6Authors Wei-Tsung Chen, Taipei City Hospital Department of Radiology Taipei TaiwanDhakshanamurthy Thirumalai, Industrial Technology Research Institute Union Chemical Laboratory Hsinchu TaiwanTiffany Ting-Fang Shih, National Taiwan University Department of Radiology, School of Medicine Taipei TaiwanR...
Source: Molecular Imaging and Biology - July 28, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Additional Value of FDG-PET/CT in Management of “Solitary” Liver Metastases: Preliminary Results of a Prospective Multicenter Studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  The addition of FDG-PET/CT to the routine assessment of patients with liver metastasis has a significant impact on disease staging and selection of suitable candidates for solitary liver metastasis resection and outcome. Content Type Journal ArticleCategory Brief ArticleDOI 10.1007/s11307-009-0249-5Authors Gaia Grassetto, ‘Santa Maria della Misericordia’ Hospital Department of Nuclear Medicine, Medical Physics, Radiology, PET Centre Viale Tre Martiri, 140 45100 Rovigo ItalyAdriano Fornasiero, General Hospital Department of Oncology Piove di Sacco Padua ItalyGiorgio Bonciarelli, General H...
Source: Molecular Imaging and Biology - July 24, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

The Use of F-18 Choline PET in the Assessment of Bone Metastases in Prostate Cancer: Correlation with Morphological Changes on CTemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  FCH-PET/CT showed promising results for the early detection of bone metastases in prostate cancer patients. We have found that a HU level of above 825 is associated with an absence of FCH uptake. Almost all of the FCH-negative sclerotic lesions were detected in patients who were under hormone therapy, which raises the possibility that these lesions might no longer be viable. However, clarification and the prognostic value of such lesions require further research. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0239-7Authors Mohsen Beheshti, St. Vincent’s Hospi...
Source: Molecular Imaging and Biology - July 9, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Modification of Aminosilanized Superparamagnetic Nanoparticles: Feasibility of Multimodal Detection Using 3T MRI, Small Animal PET, and Fluorescence Imagingemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  We conclude that our modified superparamagnetic nanoparticles are stable under in vitro and in vivo conditions and are therefore applicable for efficient cell labeling and subsequent multimodal molecular imaging. Moreover, their multiple free amino groups suggest the possibility for further modifications and might provide interesting opportunities for various research fields. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0237-9Authors Lars Stelter, Universitätsmedizin Berlin Klinik für Strahlenheilkunde, CC6, Charité Campus Virchow-Klinikum Augustenburger P...
Source: Molecular Imaging and Biology - July 7, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Evaluation of the Radiocobalt-Labeled [MMA-DOTA-Cys61]-ZHER2:2395-Cys Affibody Molecule for Targeting of HER2-Expressing Tumorsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Radiocobalt is a promising label for affibody molecules for future PET applications. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0238-8Authors Helena Wållberg, Affibody AB Bromma SwedenSara Ahlgren, Uppsala University Division of Nuclear Medicine, Department of Medical Sciences Uppsala SwedenCharles Widström, Uppsala University Hospital Hospital Physics, Department of Oncology Uppsala SwedenAnna Orlova, Affibody AB Bromma Sweden Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - June 26, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Comparison of Gene-Transfer Efficiency in Human Embryonic Stem Cellsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In this study, a bi-fusion construct with ubiquitin promoter driving enhanced green fluorescent protein reporter and the firefly luciferase (pUb-eGFP-Fluc) along with neomycin selection marker was used for in vitro and in vivo studies. In vitro studies examined the transfection efficiency and viability of each technique using two hES cell lines (male H1 and female H9 cells). Lentiviral transduction demonstrated the highest efficiency (H1: 25.3 ± 4.8%; H9: 22.4 ± 6.5%) with >95% cell viability. Nucleofection demonstrated transfection efficiency of 16.1 ± 3.6% (H1) and 5.8 ± 3.2% (H9). However, min...
Source: Molecular Imaging and Biology - June 24, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Involvement of Nigrostriatal Pathway in Japanese Encephalitis with Movement Disorders: Evidence from 99mTc-TRODAT-1 and 123I-IBZM SPECT Imagingsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  Data have suggested that presynaptic dopaminergic neurons in JE patients are more susceptible to JE virus than postsynaptic striatal neurons. The degree of movement impairment was more closely correlated to the degree of D2Rs disruption seen in 123I-IBZM SPECT imaging. Content Type Journal ArticleCategory Brief ArticleDOI 10.1007/s11307-009-0244-xAuthors Chang-Hsu Liao, Tri-Service General Hospital, National Defense Medical Center Department of Neurology Cheng-Kung Rd Section 2 Taipei 114 Taiwan Republic of ChinaZaodung Ling, National Health Research Institutes Division of Mental Health and...
Source: Molecular Imaging and Biology - June 23, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Bioluminescence Imaging in Mouse Models Quantifies β Cell Mass in the Pancreas and After Islet Transplantationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Bioluminescence in the MIP-Luc-VU mouse model is proportional to β cell mass in the setting of increased and decreased β cell mass and after transplantation. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0240-1Authors John Virostko, Vanderbilt University Institute of Imaging Science Nashville TN USAAramandla Radhika, Vanderbilt University Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism Nashville TN USAGreg Poffenberger, Vanderbilt University Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism Nashville TN US...
Source: Molecular Imaging and Biology - June 23, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

131I-Tositumomab (Bexxar®) vs.90Y-Ibritumomab (Zevalin®) Therapy of Low-Grade Refractory/Relapsed Non-Hodgkin Lymphomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  Our study suggests that clinical practice of Bexxar® and Zevalin® radioimmunotherapy is an effective and safe adjunctive treatment for patients with NHL refractory/relapsed to conventional treatment. However, due to the small number of subjects, it was not possible to determine whether differences in the outcomes or toxicities from the two agents were statistically significant. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0245-9Authors Andrei Iagaru, Stanford University Medical Center Division of Nuclear Medicine 300 Pasteur Dr, Room H-0101 Stanford CA 94305...
Source: Molecular Imaging and Biology - June 20, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Incremental Value of Integrated FDG-PET/CT in Evaluating Indeterminate Solitary Pulmonary Nodule for Malignancyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Although the benefit attributable to the CT component was limited when integrated PET/CT was used, PET and CT acted synergistically to significantly increase the diagnostic veracity for PET-indeterminate nodules. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0241-0Authors Chih-Yung Chang, Tri-Service General Hospital Department of Nuclear Medicine National Defense Medical Center, 325, Section 2, Cheng-Kung Road Taipei 114 TaiwanChing Tzao, Tri-Service General Hospital Department of Thoracic Surgery Taipei TaiwanShih-Chun Lee, Tri-Service General Hospital Depar...
Source: Molecular Imaging and Biology - June 20, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Dual Tracer 11C-Choline and FDG-PET in the Diagnosis of Biochemical Prostate Cancer Relapse After Radical Treatmentemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions   A PSA value higher than 1.9 ng/ml determines a significant increase in the diagnostic yield. Adjuvant hormonotherapy has no influence on the PET results. FDG has a better correlation with the Gleason score than 11C-choline. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0243-yAuthors José A. Richter, Universidad de Navarra Nuclear Medicine Department, Clínica Universitaria Avda, Pío XII 36 31008 Pamplona SpainMacarena Rodríguez, Universidad de Navarra Nuclear Medicine Department, Clínica Universitaria Avda, Pío XII 36 31008 Pamplona SpainJorge Rioja...
Source: Molecular Imaging and Biology - June 19, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Intravital Imaging of Tumor Apoptosis with FRET Probes During Tumor Therapyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  FRET could be used effectively to monitor activation of caspase-3 in living organism. This method could be used to provide rapid assessment of apoptosis induced by anti-tumor therapies for improvement of treatment efficacy. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0235-yAuthors Feifan Zhou, South China Normal University MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science Guangzhou 510631 ChinaDa Xing, South China Normal University MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science Guangzhou 510631 ChinaShe...
Source: Molecular Imaging and Biology - June 19, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Comparison of [18F]-Tracers in Various Experimental Tumor Models by PET Imaging and Identification of an Early Response Biomarker for the Novel Microtubule Stabilizer Patupiloneemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory ErratumDOI 10.1007/s11307-009-0246-8Authors T. Ebenhan, Novartis Institute of Biomedical Research Global Imaging Group 4002 Basel SwitzerlandM. Honer, Eidgenoessische Technische Hochschule (ETH) Zurich Animal Imaging Center-PET, Center for Radiopharmaceutical Science Wolfgang-Pauli-Strasse 10 8093 Zurich SwitzerlandS. M. Ametamey, Eidgenoessische Technische Hochschule (ETH) Zurich Animal Imaging Center-PET, Center for Radiopharmaceutical Science Wolfgang-Pauli-Strasse 10 8093 Zurich SwitzerlandP. A. Schubiger, Eidgenoessische Technische Hochschule (ETH) Zurich Animal Imaging Center-...
Source: Molecular Imaging and Biology - June 18, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Feasibility of Whole-Body Functional Mouse Imaging Using Helical Pinhole SPECTemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Helical paths can provide complete sampling data and large effective FOV, yielding 3D full-body in vivo biodistributions while still maintaining a small distance from the aperture to the object for good sensitivity and resolution. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0234-zAuthors Scott D. Metzler, University of Pennsylvania Department of Radiology 3400 Spruce St. Philadelphia PA 19104 USASreekanth Vemulapalli, Duke University Medical Center School of Medicine Durham NC 27710 USARonald J. Jaszczak, Duke University Medical Center Department of Radiology ...
Source: Molecular Imaging and Biology - June 12, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Potential of Dual Time Point FDG-PET Imaging in Differentiating Malignant from Benign Pleural Diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  There is an increasing uptake of 18F-FDG over time in pleural malignancies, whereas the uptake in benign pleural disease generally stays stable or decreases over time. Therefore, dual time point imaging appears to be an effective approach in differentiating benign from malignant pleural disease, which increases the sensitivity and is also helpful in guiding the biopsy site for a successful diagnosis. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0212-5Authors Ayse Mavi, Hospital of the University of Pennsylvania Division of Nuclear Medicine 3400 Spruce Street,...
Source: Molecular Imaging and Biology - May 27, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Comparison of [18F]-Tracers in Various Experimental Tumor Models by PET Imaging and Identification of an Early Response Biomarker for the Novel Microtubule Stabilizer Patupiloneemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  [18F]FLT PET of experimental tumors is a viable complement to [18F]FDG for preclinical drug development. [18F]FLT may be an excellent biomarker for patupilone-induced apoptosis. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0216-1Authors T. Ebenhan, Novartis Institute of Biomedical Research Global Imaging Group 4002 Basel SwitzerlandM. Honer, Eidgenoessische Technische Hochschule (ETH) Zurich Animal Imaging Center-PET, Center for Radiopharmaceutical Science Wolfgang-Pauli-Strasse 10 CH-8093 Zurich SwitzerlandS.M. Ametamey, Eidgenoessische Technische Hochschule (E...
Source: Molecular Imaging and Biology - May 22, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Death and Proliferation Time Course of Stem Cells Transplanted in the Myocardiumemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  The time course of transplanted stem cells surviving in the heart reveals a process of substantial cell loss within 24 h of injection and subsequent recovery of cell number through proliferation. Such proliferation can be noninvasively monitored by reporter gene imaging. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0222-3Authors Hui Qiao, University of Pennsylvania Department of Radiology Philadelphia PA 19104 USASuleman Surti, University of Pennsylvania Department of Radiology Philadelphia PA 19104 USASeok Rye Choi, University of Pennsylvania Department...
Source: Molecular Imaging and Biology - May 21, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Initial Experience with the Radiotracer Anti-1-amino-3-[18F]Fluorocyclobutane-1-Carboxylic Acid (Anti-[18F]FACBC) with PET in Renal Carcinomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  In this small patient sample, relative amino acid transport compared with renal cortex is elevated in renal papillary cell carcinoma but not in clear cell carcinoma. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0220-5Authors David M. Schuster, Emory University Department of Radiology, Division of Nuclear Medicine Atlanta GA USAJonathon A. Nye, Emory University Department of Radiology, Division of Nuclear Medicine Atlanta GA USAPeter T. Nieh, Emory University Department of Urology Atlanta GA USAJohn R. Votaw, Emory University Department of Radiology, Division o...
Source: Molecular Imaging and Biology - May 16, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

A Convenient Thiazole Orange Fluorescence Assay for the Evaluation of DNA Duplex Hybridization Stabilityemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  When study duplexes shown to be stable in serum were incubated with their target cells, the assay successfully detected evidence of dissociation, most likely by an antisense mechanism. Thus, a TO fluorescence assay has been developed that is capable of detecting the dissociation of DNA duplexes. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0221-4Authors Minmin Liang, University of Massachusetts Medical School Department of Radiology Worcester MA 01655 USAXinrong Liu, University of Massachusetts Medical School Department of Radiology Worcester MA 01655 USAKayo...
Source: Molecular Imaging and Biology - May 15, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Imaging Correlates of Differential Expression of Indoleamine 2,3-Dioxygenase in Human Brain Tumorsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  Low-grade tumors show widespread IDO expression, while IDO expression in high-grade brain tumors can be absent or largely confined to endothelial cells. AMT PET can be useful to identify brain tumors with different profiles of IDO expression, thus providing a useful imaging marker for emerging treatments targeting tumor IDO activity. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0225-0Authors Carlos E. A. Batista, Wayne State University Carman and Ann Adams Department of Pediatrics, School of Medicine Detroit MI USACsaba Juhász, Wayne State University Carman a...
Source: Molecular Imaging and Biology - May 12, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Early Assessment of Therapeutic Response using FDG PET in Small Cell Lung Canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  FDG PET has the potential to identify the therapeutic response in patients with SCLC as early as after the first cycle of chemotherapy. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0227-yAuthors Y. Yamamoto, Kagawa University Department of Radiology, Faculty of Medicine Kita-gun Kagawa JapanR. Kameyama, Kagawa University Department of Radiology, Faculty of Medicine Kita-gun Kagawa JapanM. Murota, Kagawa University Department of Radiology, Faculty of Medicine Kita-gun Kagawa JapanS. Bandoh, Kagawa University Department of First Internal Medicine, Faculty of Med...
Source: Molecular Imaging and Biology - May 12, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Simulations of Virtual PET/CT 3-D Bronchoscopy Imaging Using a Physical Porcine Lung–Heart Phantomemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  We have demonstrated a phantom model for studies of PET/CT 3-D virtual fly-through bronchoscopy and have applied this model for understanding the effect of PET thresholding on the visualization and detection of lesions. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0201-8Authors David Yerushalmi, Stanford University Department of Bioengineering The James H. Clark Center, 318 Campus Drive, E150 Stanford CA 94305 USARakesh Mullick, John F. Welch Technology Center, GE Global Research Imaging Technologies Lab Bangalore IndiaAndrew Quon, Stanford University Departmen...
Source: Molecular Imaging and Biology - May 12, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Imaging Uterine Cervical Cancer with FDG-PET/CT: Direct Comparison with PETemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  PET/CT was demonstrated to be useful in the definite localization and characterization of foci of increased FDG uptake, which provided its higher diagnostic accuracy than PET alone. PET/CT appears preferable to PET in the evaluation of cervical cancer, although additional study is needed. Content Type Journal ArticleCategory Brief ArticleDOI 10.1007/s11307-008-0180-1Authors Mitsuaki Tatsumi, Johns Hopkins Medical Institutions Division of Nuclear Medicine, Department of Radiology 601 North Caroline Street, Room 3223A Baltimore MD 21287-0817 USAChristian Cohade, Johns Hopkins Medical Institut...
Source: Molecular Imaging and Biology - May 12, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

64Cu-Labeled PEGylated Polyethylenimine for Cell Trafficking and Tumor Imagingemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion   64Cu-labeled polyethylenimine can be used for both cell trafficking and tumor imaging. PEGylation reduces the toxicity of 64Cu-PEI and improves the tumor imaging ability. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0228-xAuthors Zi-Bo Li, Stanford University School of Medicine The Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program Stanford CA USAKai Chen, Stanford University School of Medicine The Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program Stanford CA USAZhanhong Wu, Stanford Un...
Source: Molecular Imaging and Biology - May 9, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Impact of Nonhybrid 99mTc-MDP-SPECT/CT Image Fusion in Diagnostic and Treatment of Oromaxillofacial Malignanciesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  Manual image fusion of CT and SPECT does not improve identification of bone infiltration compared to simultaneous evaluation. Though particularly in complex anatomical regions, a fixed preoperative diagnostic algorithm in image registration lead to a more precise evaluation and treatment of head and neck malignancies. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0231-2Authors Denys John Loeffelbein, Technische Universität München Department of Oral and Maxillofacial Surgery Ismaninger Str.22 81675 München GermanyEckhart Mielke, Ruhr-University Bochum Depart...
Source: Molecular Imaging and Biology - May 9, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Correlating Metabolic Activity with Cellular Proliferation in Follicular Lymphomasemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  The increasing trend of metabolic activity across follicular lymphoma grades correlates with cellular proliferation. The metabolic information from positron emission tomography–computed tomography may offer another useful parameter in the management of follicular lymphomas. Content Type Journal ArticleCategory Rapid CommunicationDOI 10.1007/s11307-009-0226-zAuthors Bingfeng Tang, William Beaumont Hospital Positron Diagnostic Center and Medical Cyclotron, Department of Nuclear Medicine Royal Oak MI USAJozef Malysz, William Beaumont Hospital Department of Pathology Royal Oak MI USAVonda Dou...
Source: Molecular Imaging and Biology - May 9, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

PET/CT in the Evaluation of Inflammatory Bowel Disease: Studies in Patients Before and After Treatmentemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  Appropriate FDG-PET determination decreases with successful treatment of inflammation in active IBD and correlates with symptom improvement. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0232-1Authors Bret J. Spier, University of Wisconsin Hospital and Clinics in Madison Department of Gastroenterology and Hepatology Madison WI USAScott B. Perlman, University of Wisconsin Hospital and Clinics in Madison Department of Radiology Madison WI USAChristine J. Jaskowiak, University of Wisconsin Hospital and Clinics in Madison Department of Radiology Madison WI USAMark R...
Source: Molecular Imaging and Biology - May 9, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals