Molecular Imaging of Fibroblast Activation in Rabbit Atherosclerotic Plaques: a Preclinical PET/CT Study
ConclusionsWe successfully achieve molecular imaging of fibroblast activation in atherosclerotic lesions of rabbits, suggesting Al18F-NOTA-FAPI-04 PET/CT may be a potentially valuable tool to identify plaques. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - April 25, 2024 Category: Molecular Biology Source Type: research
PDX Models in Theranostic Applications: Generation and Screening for B Cell Lymphoma of Human Origin
AbstractThis MIB guide briefly summarizes the generation of patient-derived xenografts (PDXs) and highlights the importance of validating PDX models for the presence of B cell lymphoma of human origin before their use in radiotheranostic applications. The use of this protocol will allow researchers to learn different methods for screening PDX models for Epstein-Barr virus (EBV)-infected B cell lymphoma. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - April 22, 2024 Category: Molecular Biology Source Type: research
Left Ventricular Remodelling Associated with the Transient Elevated [68Ga]Ga-Pentixafor Activity in the Remote Myocardium Following Acute Myocardial Infarction
ConclusionsCorresponding with the peaked [68Ga]Ga-Pentixafor activity in the infarcted myocardium, the activity in the remote region elevated accordingly and led to contemporaneous left ventricular remodelling early after AMI. Further studies are warranted to clarify its clinical application potential. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - April 19, 2024 Category: Molecular Biology Source Type: research
Comparison of [18F]FDG and [68 Ga]pentixafor PET/CT in Nasopharyngeal Carcinoma
Conclusions[68 Ga]pentixafor is a promising imaging tracer for detecting primary and metastatic NPC. [68 Ga]pentixafor PET/CT is comparable to [18F]FDG PET/CT in the detection rate of primary tumors and metastatic cervical lymph nodes in nasopharyngeal carcinoma, but [68 Ga]pentixafor uptake was heterogeneous. [68 Ga]pentixafor PET/CT may help select patients most likely to benefit from CXCR4-directed endoradiotherapy.Clinical trial registration No.: ChiCTR2200065902 (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - April 16, 2024 Category: Molecular Biology Source Type: research
In Vivo Labeling and Detection of Circulating Tumor Cells in Mice Using OTL38
ConclusionsThis work shows the feasibility of labeling CTCsin vivo with OTL38 and detection with DiFC. Although further refinement of the DiFC instrument and signal processing algorithms and testing with other animal models is needed, this work may eventually pave the way for human use of DiFC. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - April 9, 2024 Category: Molecular Biology Source Type: research
Correction: Sub-Chronic Ketamine Administration Increases Dopamine Synthesis Capacity in the Mouse Midbrain: a Preclinical In Vivo PET Study
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - April 3, 2024 Category: Molecular Biology Source Type: research
Sensing and Imaging Molecular Oxygen in Mammals with Spin Lattice Relaxation Electron Paramagnetic Resonance
AbstractMolecular oxygen and its thermodynamic transformation drive nearly all life processes. Quantitative measurement and imaging of oxygen in living systems is of fundamental importance for the study of life processes and their aberrations —disease– many of which are affected by hypoxia, or low levels of oxygen. Cancer is among the disease processes profoundly affected by hypoxia. Electron paramagnetic resonance has been shown to provide remarkably accurate images of normal and cancerous tissue. In this review, we emphasize the re activity of molecular oxygen particularly highlighting the metabolic processes of livi...
Source: Molecular Imaging and Biology - March 28, 2024 Category: Molecular Biology Source Type: research
Highly Sensitive Detection of Melanin in Melanomas Using Multi-harmonic Low Frequency EPR
ConclusionsOverall, our results are paving the way for new clinical trials that will use MH clinical EPR for the characterization of pigmented skin lesions. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - March 22, 2024 Category: Molecular Biology Source Type: research
Passing the Molecular Imaging and Biology Torch
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - March 21, 2024 Category: Molecular Biology Source Type: research
Hybrid Molecular and Functional Micro-CT Imaging Reveals Increased Myocardial Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice
ConclusionsThis study highlights the utility of combined functional micro-CT and FMT imaging in assessing cardiac function and detecting apoptosis, providing valuable insights into the potential of apoptosis as an early biomarker for cardiac failure. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - March 18, 2024 Category: Molecular Biology Source Type: research
Development of New CD38 Targeted Peptides for Cancer Imaging
ConclusionsThe novel CD38-targeted, radiolabeled bioconjugates were specific and allowed visualization of MM, providing a starting point for the clinical translation of such tracers for the detection of MM. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - March 13, 2024 Category: Molecular Biology Source Type: research
Test –Retest Repeatability of Patlak Slopes versus Standardized Uptake Values for Hypermetabolic Lesions and Normal Organs in an Oncologic PET/CT Population
ConclusionsAmong [18F]FDG-avid lesions, the repeatability of PS-based metrics is similar to equivalent SUV-based metrics at late post-injection time points, indicating that PS-based metrics may be suitable for tracking response to oncologic therapies. However, further validation is required in light of our study ’s limitations, including small sample size and bias toward higher retest values for some metrics. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - March 11, 2024 Category: Molecular Biology Source Type: research
MRI-Based Cell Tracking of OATP-Expressing Cell Transplants by Pre-Labeling with Gd-EOB-DTPA
ConclusionsOATP1B3-expressing cells can be pre-labeled with Gd-EOB-DTPA prior to injection into tissue, affording the use of clinically familiar T1-weighted MRI to robustly detect cell transplants immediately after transplant. This procedure is easily generalizable and has potential advantages over the use of iron oxide based cell labeling agents and imaging procedures. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - March 6, 2024 Category: Molecular Biology Source Type: research
MIB Guides: Measuring the Immunoreactivity of Radioimmunoconjugates
AbstractImmunoglobulins, both full-length antibodies and smaller antibody fragments, have long been regarded as effective platforms for diagnostic and therapeutic radiopharmaceuticals. The construction of radiolabeled immunoglobulins (i.e., radioimmunoconjugates) requires the manipulation of the biomolecule through the attachment of a radiohalogenor the bioconjugation of a chelator that is subsequently used to coordinate a radiometal. Both synthetic approaches have historically relied upon the stochastic modification of amino acids within the immunoglobulin, a process which poses a risk to the structural and functional int...
Source: Molecular Imaging and Biology - March 6, 2024 Category: Molecular Biology Source Type: research
Use of Indocyanine Green Near-Infrared Imaging for Sentinel Lymph Node Biopsy in Early Oral Squamous Cell Carcinoma: A Pilot Study
ConclusionsOur study shows that ICG-guided SLN biopsy is a feasible technique, especially in combination with conventional radioisotope method and may help for intraoperative localization of SLN. Validation studies with bigger patient cohorts are needed to prove our results. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - March 5, 2024 Category: Molecular Biology Source Type: research
