Ischemic stroke and diabetes: a TLR4-mediated neuroinflammatory perspective
J Mol Med (Berl). 2024 Mar 28. doi: 10.1007/s00109-024-02441-9. Online ahead of print.ABSTRACTIschemic stroke is the major contributor to morbidity and mortality in people with diabetes mellitus. In ischemic stroke patients, neuroinflammation is now understood to be one of the main underlying mechanisms for cerebral damage and recovery delay. It has been well-established that toll-like receptor 4 (TLR4) signaling pathway plays a key role in neuroinflammation. Emerging research over the last decade has revealed that, compared to ischemic stroke without diabetes mellitus, ischemic stroke with diabetes mellitus significantly ...
Source: Molecular Medicine - March 28, 2024 Category: Molecular Biology Authors: Thura Tun Oo Source Type: research

Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose
CONCLUSIONS: T-614 is an allosteric inhibitor of MIF that prevented death and decreased hepatic hydrogen peroxide concentrations when given prophylactically in a murine model of acetaminophen overdose. Further studies are needed to elucidate the mechanistic role of MIF in APAP toxicity.PMID:38539088 | DOI:10.1186/s10020-024-00803-0 (Source: Molecular Medicine)
Source: Molecular Medicine - March 28, 2024 Category: Molecular Biology Authors: Joshua Bloom Georgios Pantouris Mingzhu He Bayan Aljabari Lopa Mishra Ramu Manjula Andrew Parkins Elias J Lolis Yousef Al-Abed Source Type: research

Early HbA1c Levels as a Predictor of Adverse Obstetric Outcomes: A Systematic Review and Meta-Analysis
Conclusions: Women with high early HbA1c levels below the range of diabetes presented an increased risk of pregnancy complications such as macrosomia, LGA, and pre-eclampsia. An early HbA1c threshold of >39 mmol/mol (5.7%) showed the strongest association with pregnancy complications.PMID:38541957 | DOI:10.3390/jcm13061732 (Source: Molecular Medicine)
Source: Molecular Medicine - March 28, 2024 Category: Molecular Biology Authors: Laura Ma ñé Humberto Navarro Juan Pedro-Botet Juan Jos é Chillarón Silvia Ballesta Antonio Pay à Ver ónica Amador Juana Antonia Flores-Le Roux David Benaiges Source Type: research

< em > Nocardia cyriacigeorgica < /em > Elicits Gut Disturbances in a Leaky Gut Model of Colitis, but Not the Harmful Cascade Leading to Gut-First Parkinson's Disease
This study indicates that aSyn aggregation plus mitochondrial dysfunction without intestinal barrier leakage are not sufficient to trigger gut-first PD.PMID:38542396 | DOI:10.3390/ijms25063423 (Source: Molecular Medicine)
Source: Molecular Medicine - March 28, 2024 Category: Molecular Biology Authors: Jo ão Duarte Magalhães Emanuel Candeias In ês Melo-Marques Ant ónio E Abreu Ana Raquel Pereira-Santos Ana Raquel Esteves Sandra Morais Cardoso Nuno Empadinhas Source Type: research

Phosphoserine aminotransferase deficiency diagnosed by whole-exome sequencing and LC-MS/MS reanalysis: A case report and review of literature
CONCLUSIONS: Our findings demonstrate the importance of WES combined with LC-MS/MS reanalysis in the diagnosis of genetic diseases and expand the PSAT1 variant spectrum in PSATD. Moreover, we summarize all the cases caused by PSAT1 variants in the literature. This case provides a vital reference for the diagnosis of future cases.PMID:38546032 | DOI:10.1002/mgg3.2400 (Source: Molecular Medicine)
Source: Molecular Medicine - March 28, 2024 Category: Molecular Biology Authors: Jiaci Li Xinping Wei Yuchen Sun Xiaofang Chen Ying Zhang Xiaoyu Cui Jianbo Shu Dong Li Chunquan Cai Source Type: research

A novel variant in ASNS gene responsible for syndromic intellectual disability and microcephaly: Case report and literature review
CONCLUSION: In the present study, a novel homozygous variant was recognized in the ASNS gene in an Iranian-Azeri girl manifesting typical ASNSD symptoms, particularly intellectual disability and microcephaly. This study expands the mutation spectrum of ASNSD and reviews previously reported patients.PMID:38546112 | DOI:10.1002/mgg3.2424 (Source: Molecular Medicine)
Source: Molecular Medicine - March 28, 2024 Category: Molecular Biology Authors: Mohammad Jahanpanah Diana Mokhtari Haleh Mokaber Sara Arish Farzad Ahmadabadi Behzad Davarnia Source Type: research

Role of the gut microbiota and innate immunity in polycystic ovary syndrome: Current updates and future prospects
This study reviewed recent research advances about the role of gut microbiota in PCOS. In order to provide basis for prevention and treatment of PCOS based on gut microbiota.PMID:38546608 | DOI:10.1111/jcmm.18258 (Source: Molecular Medicine)
Source: Molecular Medicine - March 28, 2024 Category: Molecular Biology Authors: Min Zhou Jing Yu Xuewei Li Zheng Ruan Shaohui Yu Source Type: research

KLF transcription factors in bone diseases
J Cell Mol Med. 2024 Apr;28(8):e18278. doi: 10.1111/jcmm.18278.ABSTRACTKrüppel-like factors (KLFs) are crucial in the development of bone disease. They are a family of zinc finger transcription factors that are unusual in containing three highly conserved zinc finger structural domains interacting with DNA. It has been discovered that it engages in various cell functions, including proliferation, apoptosis, autophagy, stemness, invasion and migration, and is crucial for the development of human tissues. In recent years, the role of KLFs in bone physiology and pathology has received adequate attention. In addition to regul...
Source: Molecular Medicine - March 28, 2024 Category: Molecular Biology Authors: Haixia Wang Juanjuan Han Gorbachev Dmitrii Ke Ning Xin-An Zhang Source Type: research

HINT2 protects against pressure overload-induced cardiac remodelling through mitochondrial pathways
J Cell Mol Med. 2024 Apr;28(8):e18276. doi: 10.1111/jcmm.18276.ABSTRACTHistidine triad nucleotide-binding protein 2 (HINT2) is an enzyme found in mitochondria that functions as a nucleotide hydrolase and transferase. Prior studies have demonstrated that HINT2 plays a crucial role in ischemic heart disease, but its importance in cardiac remodelling remains unknown. Therefore, the current study intends to determine the role of HINT2 in cardiac remodelling. HINT2 expression levels were found to be lower in failing hearts and hypertrophy cardiomyocytes. The mice that overexpressed HINT2 exhibited reduced myocyte hypertrophy an...
Source: Molecular Medicine - March 28, 2024 Category: Molecular Biology Authors: Nan Zhang Zi-Ying Zhou Yan-Yan Meng Hai-Han Liao Shan-Qi Mou Zheng Lin Han Yan Si Chen Qi-Zhu Tang Source Type: research

Research progress of the netrins and their receptors in cancer
J Cell Mol Med. 2024 Apr;28(8):e18241. doi: 10.1111/jcmm.18241.ABSTRACTNetrins, a family of secreted and membrane-associated proteins, can regulate axonal guidance, morphogenesis, angiogenesis, cell migration, cell survival, and tumorigenesis. Four secreted netrins (netrin 1, 3, 4 and 5) and two glycosylphosphatidylinositols-anchored membrane proteins, netrin-G1 and G2, have been identified in mammals. Netrins and their receptors can serve as a biomarker and molecular therapeutic target for pathological differentiation, diagnosis and prognosis of malignant cancers. We review here the potential roles of the netrins family a...
Source: Molecular Medicine - March 28, 2024 Category: Molecular Biology Authors: Xing Gao Jiazhou Ye Xi Huang Shilin Huang Wenfeng Luo Dandan Zeng Shizhou Li Minchao Tang Rongyun Mai Yongqiang Li Yan Lin Rong Liang Source Type: research

Involvement of DJ-1 in the pathogenesis of intervertebral disc degeneration via hexokinase 2-mediated mitophagy
This study aimed to clarify the role of DJ-1 in regulating mitophagy during IDD pathogenesis. Here, we showed that the mitochondrial localization of DJ-1 in nucleus pulposus cells (NPCs) first increased and then decreased in response to oxidative stress. Subsequently, loss- and gain-of-function experiments revealed that overexpression of DJ-1 in NPCs inhibited oxidative stress-induced mitochondrial dysfunction and mitochondria-dependent apoptosis, whereas knockdown of DJ-1 had the opposite effect. Mechanistically, mitochondrial translocation of DJ-1 promoted the recruitment of hexokinase 2 (HK2) to damaged mitochondria by ...
Source: Molecular Medicine - March 27, 2024 Category: Molecular Biology Authors: Jialiang Lin Longjie Wang Yuhao Wu Qian Xiang Yongzhao Zhao Xuanqi Zheng Shuai Jiang Zhuoran Sun Dongwei Fan Weishi Li Source Type: research

Extracellular vesicle-mediated transfer of miRNA-1 from primary tumors represses the growth of distant metastases
Exp Mol Med. 2024 Mar 27. doi: 10.1038/s12276-024-01181-7. Online ahead of print.ABSTRACTMetastases originate from primary tumors and reach distant organs. Growing evidence suggests that metastases are under the control of primary tumors even outside the primary site; however, the mechanisms by which primary tumors remotely control metastases remain unclear. Here, we discovered a molecular mechanism by which primary tumors suppress metastatic growth. Interestingly, we found that extracellular vesicles (EVs) derived from the primary tumor can inhibit the growth of metastases both in vitro and in vivo. miR-1 was particularly...
Source: Molecular Medicine - March 27, 2024 Category: Molecular Biology Authors: Chae-Yi Kim Kang-Hoon Lee Keun Hong Son Tae-Jin Shin Je-Yoel Cho Source Type: research

Macrophage mannose receptor CD206 targeting of fluoride-18 labeled mannosylated dextran: A validation study in mice
CONCLUSION: The uptake of mannosylated dextran derivative Al[18F]F-NOTA-D10CM correlated with CD206 expression and the tracer appears promising for inflammation imaging.PMID:38532026 | DOI:10.1007/s00259-024-06686-x (Source: Molecular Medicine)
Source: Molecular Medicine - March 27, 2024 Category: Molecular Biology Authors: Putri Andriana Ruth Fair-M äkelä Heidi Liljenb äck Salli K ärnä Imran Iqbal Konstantina Makrypidi Johan Rajander Ioannis Pirmettis Xiang-Guo Li Sirpa Jalkanen Antti Saraste Marko Salmi Anne Roivainen Source Type: research

Diagnostic imaging of the diabetic foot: an EANM evidence-based guidance
CONCLUSION: These practical recommendations highlight, and should assist clinicians in understanding, the role of imaging in the diagnostic workup of diabetic foot complications.PMID:38532027 | DOI:10.1007/s00259-024-06693-y (Source: Molecular Medicine)
Source: Molecular Medicine - March 27, 2024 Category: Molecular Biology Authors: Chiara Lauri Edel Noriega- Álvarez Riddhika M Chakravartty Olivier Gheysens Andor W J M Glaudemans Riemer H J A Slart Thomas C Kwee Fr édéric Lecouvet Emmanouil Panagiotidis Jules Zhang-Yin Jose Luis Lazaro Martinez Benjamin A Lipsky Luigi Uccioli Albe Source Type: research

Integration of single-cell and RNA-seq data to explore the role of focal adhesion-related genes in osteoporosis
In conclusion, two hub genes related to focal adhesion were identified by combined scRNA-seq and RNA-seq analyses, which might supply a new insight for the treatment and evaluation of OP.PMID:38534087 | PMC:PMC10967139 | DOI:10.1111/jcmm.18271 (Source: Molecular Medicine)
Source: Molecular Medicine - March 27, 2024 Category: Molecular Biology Authors: Xiaojian Shi Qiang Fu Jianyu Mao Jiajie Yang Ye Chen Jiajia Lu Aimin Chen Nan Lu Source Type: research