Advances in microRNA regulation of deep vein thrombosis through venous vascular endothelial cells (Review)
Mol Med Rep. 2024 Jun;29(6):96. doi: 10.3892/mmr.2024.13220. Epub 2024 Apr 12.ABSTRACTDeep vein thrombosis (DVT) is a prevalent clinical venous thrombotic condition that often manifests independently or in conjunction with other ailments. Thrombi have the propensity to dislodge into the circulatory system, giving rise to complications such as pulmonary embolism, thereby posing a significant risk to the patient. Virchow proposed that blood stagnation, alterations in the vessel wall and hypercoagulation are primary factors contributing to the development of venous thrombosis. Vascular endothelial cells (VECs) constitute the ...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Chucun Fang Feng Huang Mengting Yao Zilong Wang Jiacheng Ma Dongwen Wu Tianting Guo Fei Zhang Jianwen Mo Source Type: research
Protective effect of quercetin on lipopolysaccharide ‑induced miscarriage based on animal experiments and network pharmacology
Mol Med Rep. 2024 Jun;29(6):99. doi: 10.3892/mmr.2024.13223. Epub 2024 Apr 12.ABSTRACTSpontaneous abortion (SA) occurs in woman of child‑bearing age, jeopardizing their physical and mental health. Quercetin is a natural flavonoid, which exhibits a variety of pharmacological activities. However, the role and mechanisms of quercetin in SA still need to be further explored. Animal experiments were performed to examine the effect of quercetin in treating SA. Institute of Cancer Research mice were injected with lipopolysaccharide into the tail vein on the 7th day of gestation to establish a SA model. Gavage was performed duri...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Shuangyu Wu Ye Tian Qiying Zhang Zhujing Fu Huizhen Lan Xuanle Zhou Ling Ma Yiyun Lou Source Type: research
Chromatin looping links gene expression to the assembly of transcription factories (Review)
Mol Med Rep. 2024 Jun;29(6):97. doi: 10.3892/mmr.2024.13221. Epub 2024 Apr 12.ABSTRACTGenes are not randomly dispersed within the nuclear space, instead they occupy precise sites either with respect to the nuclear lamina as well as to each other. This observation stands at the basis of the today well accepted concept of nuclear territories where any chromosome shows reproducible spatial connections with a selection of others in a general picture that meets a functional criterion where genes that answer the same stimuli are grouped in the same sites. In fact, transcription is not visible widely dispersed throughout the nucl...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Bruno Perillo Antimo Migliaccio Gabriella Castoria Source Type: research
MicroRNA ‑mediated regulation of muscular atrophy: Exploring molecular pathways and therapeutics (Review)
In conclusion, the present review lays a foundation for the development of novel treatment options for individuals affected by muscular atrophy, and explores other regulatory pathways, such as autophagy and inflammatory signaling, to ensure a comprehensive overview of the multifarious nature of muscular atrophy. The objective of the present review was to elucidate the complex molecular pathways involved in muscular atrophy, and to facilitate the development of innovative and specific therapeutic strategies for the prevention or reversal of muscular atrophy in diverse clinical scenarios.PMID:38606516 | DOI:10.3892/mmr.2024....
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Woohyeong Jung Uijin Juang Suhwan Gwon Hounggiang Nguyen Qingzhi Huang Soohyeon Lee Beomwoo Lee So-Hee Kwon Seon-Hwan Kim Jongsun Park Source Type: research
[Retracted] Propofol modulates the proliferation, invasion and migration of bladder cancer cells through the miR ‑145‑5p/TOP2A axis
Mol Med Rep. 2024 Jun;29(6):94. doi: 10.3892/mmr.2024.13218. Epub 2024 Apr 12.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the tumour images shown in Fig. 6B on p. 8 were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes, which had either already been published or were under consideration for publication at around the same time. Owing to the fact that the contentious data in the above article were already under consideration for publication prior to its submission to Mol...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Yi Du Xudong Zhang Hongwei Zhang Yiding Chen Shuying Zhu Jinjun Shu Hui Pan Source Type: research
Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation ‑mediating treatment options (Review)
Mol Med Rep. 2024 Jun;29(6):95. doi: 10.3892/mmr.2024.13219. Epub 2024 Apr 12.ABSTRACTObesity reaches up to epidemic proportions globally and increases the risk for a wide spectrum of co‑morbidities, including type‑2 diabetes mellitus (T2DM), hypertension, dyslipidemia, cardiovascular diseases, non‑alcoholic fatty liver disease, kidney diseases, respiratory disorders, sleep apnea, musculoskeletal disorders and osteoarthritis, subfertility, psychosocial problems and certain types of cancers. The underlying inflammatory mechanisms interconnecting obesity with metabolic dysfunction are not completely understood. Increas...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Fani-Niki Varra Michail Varras Viktoria-Konstantina Varra Panagiotis Theodosis-Nobelos Source Type: research
Advances in microRNA regulation of deep vein thrombosis through venous vascular endothelial cells (Review)
Mol Med Rep. 2024 Jun;29(6):96. doi: 10.3892/mmr.2024.13220. Epub 2024 Apr 12.ABSTRACTDeep vein thrombosis (DVT) is a prevalent clinical venous thrombotic condition that often manifests independently or in conjunction with other ailments. Thrombi have the propensity to dislodge into the circulatory system, giving rise to complications such as pulmonary embolism, thereby posing a significant risk to the patient. Virchow proposed that blood stagnation, alterations in the vessel wall and hypercoagulation are primary factors contributing to the development of venous thrombosis. Vascular endothelial cells (VECs) constitute the ...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Chucun Fang Feng Huang Mengting Yao Zilong Wang Jiacheng Ma Dongwen Wu Tianting Guo Fei Zhang Jianwen Mo Source Type: research
Protective effect of quercetin on lipopolysaccharide ‑induced miscarriage based on animal experiments and network pharmacology
Mol Med Rep. 2024 Jun;29(6):99. doi: 10.3892/mmr.2024.13223. Epub 2024 Apr 12.ABSTRACTSpontaneous abortion (SA) occurs in woman of child‑bearing age, jeopardizing their physical and mental health. Quercetin is a natural flavonoid, which exhibits a variety of pharmacological activities. However, the role and mechanisms of quercetin in SA still need to be further explored. Animal experiments were performed to examine the effect of quercetin in treating SA. Institute of Cancer Research mice were injected with lipopolysaccharide into the tail vein on the 7th day of gestation to establish a SA model. Gavage was performed duri...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Shuangyu Wu Ye Tian Qiying Zhang Zhujing Fu Huizhen Lan Xuanle Zhou Ling Ma Yiyun Lou Source Type: research
Chromatin looping links gene expression to the assembly of transcription factories (Review)
Mol Med Rep. 2024 Jun;29(6):97. doi: 10.3892/mmr.2024.13221. Epub 2024 Apr 12.ABSTRACTGenes are not randomly dispersed within the nuclear space, instead they occupy precise sites either with respect to the nuclear lamina as well as to each other. This observation stands at the basis of the today well accepted concept of nuclear territories where any chromosome shows reproducible spatial connections with a selection of others in a general picture that meets a functional criterion where genes that answer the same stimuli are grouped in the same sites. In fact, transcription is not visible widely dispersed throughout the nucl...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Bruno Perillo Antimo Migliaccio Gabriella Castoria Source Type: research
MicroRNA ‑mediated regulation of muscular atrophy: Exploring molecular pathways and therapeutics (Review)
In conclusion, the present review lays a foundation for the development of novel treatment options for individuals affected by muscular atrophy, and explores other regulatory pathways, such as autophagy and inflammatory signaling, to ensure a comprehensive overview of the multifarious nature of muscular atrophy. The objective of the present review was to elucidate the complex molecular pathways involved in muscular atrophy, and to facilitate the development of innovative and specific therapeutic strategies for the prevention or reversal of muscular atrophy in diverse clinical scenarios.PMID:38606516 | DOI:10.3892/mmr.2024....
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Woohyeong Jung Uijin Juang Suhwan Gwon Hounggiang Nguyen Qingzhi Huang Soohyeon Lee Beomwoo Lee So-Hee Kwon Seon-Hwan Kim Jongsun Park Source Type: research
[Retracted] Propofol modulates the proliferation, invasion and migration of bladder cancer cells through the miR ‑145‑5p/TOP2A axis
Mol Med Rep. 2024 Jun;29(6):94. doi: 10.3892/mmr.2024.13218. Epub 2024 Apr 12.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the tumour images shown in Fig. 6B on p. 8 were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes, which had either already been published or were under consideration for publication at around the same time. Owing to the fact that the contentious data in the above article were already under consideration for publication prior to its submission to Mol...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Yi Du Xudong Zhang Hongwei Zhang Yiding Chen Shuying Zhu Jinjun Shu Hui Pan Source Type: research
Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation ‑mediating treatment options (Review)
Mol Med Rep. 2024 Jun;29(6):95. doi: 10.3892/mmr.2024.13219. Epub 2024 Apr 12.ABSTRACTObesity reaches up to epidemic proportions globally and increases the risk for a wide spectrum of co‑morbidities, including type‑2 diabetes mellitus (T2DM), hypertension, dyslipidemia, cardiovascular diseases, non‑alcoholic fatty liver disease, kidney diseases, respiratory disorders, sleep apnea, musculoskeletal disorders and osteoarthritis, subfertility, psychosocial problems and certain types of cancers. The underlying inflammatory mechanisms interconnecting obesity with metabolic dysfunction are not completely understood. Increas...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Fani-Niki Varra Michail Varras Viktoria-Konstantina Varra Panagiotis Theodosis-Nobelos Source Type: research
Advances in microRNA regulation of deep vein thrombosis through venous vascular endothelial cells (Review)
Mol Med Rep. 2024 Jun;29(6):96. doi: 10.3892/mmr.2024.13220. Epub 2024 Apr 12.ABSTRACTDeep vein thrombosis (DVT) is a prevalent clinical venous thrombotic condition that often manifests independently or in conjunction with other ailments. Thrombi have the propensity to dislodge into the circulatory system, giving rise to complications such as pulmonary embolism, thereby posing a significant risk to the patient. Virchow proposed that blood stagnation, alterations in the vessel wall and hypercoagulation are primary factors contributing to the development of venous thrombosis. Vascular endothelial cells (VECs) constitute the ...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Chucun Fang Feng Huang Mengting Yao Zilong Wang Jiacheng Ma Dongwen Wu Tianting Guo Fei Zhang Jianwen Mo Source Type: research
Protective effect of quercetin on lipopolysaccharide ‑induced miscarriage based on animal experiments and network pharmacology
Mol Med Rep. 2024 Jun;29(6):99. doi: 10.3892/mmr.2024.13223. Epub 2024 Apr 12.ABSTRACTSpontaneous abortion (SA) occurs in woman of child‑bearing age, jeopardizing their physical and mental health. Quercetin is a natural flavonoid, which exhibits a variety of pharmacological activities. However, the role and mechanisms of quercetin in SA still need to be further explored. Animal experiments were performed to examine the effect of quercetin in treating SA. Institute of Cancer Research mice were injected with lipopolysaccharide into the tail vein on the 7th day of gestation to establish a SA model. Gavage was performed duri...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Shuangyu Wu Ye Tian Qiying Zhang Zhujing Fu Huizhen Lan Xuanle Zhou Ling Ma Yiyun Lou Source Type: research
Chromatin looping links gene expression to the assembly of transcription factories (Review)
Mol Med Rep. 2024 Jun;29(6):97. doi: 10.3892/mmr.2024.13221. Epub 2024 Apr 12.ABSTRACTGenes are not randomly dispersed within the nuclear space, instead they occupy precise sites either with respect to the nuclear lamina as well as to each other. This observation stands at the basis of the today well accepted concept of nuclear territories where any chromosome shows reproducible spatial connections with a selection of others in a general picture that meets a functional criterion where genes that answer the same stimuli are grouped in the same sites. In fact, transcription is not visible widely dispersed throughout the nucl...
Source: Molecular Medicine Reports - April 12, 2024 Category: Molecular Biology Authors: Bruno Perillo Antimo Migliaccio Gabriella Castoria Source Type: research
