Melatonin: a ferroptosis inhibitor with potential therapeutic efficacy for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration
The unprecedented pandemic of COVID-19 swept millions of lives in a short period, yet its menace continues among its survivors in the form of post-COVID syndrome. An exponentially growing number of COVID-19 su... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 19, 2024 Category: Neurology Authors: Asmaa Yehia and Osama A. Abulseoud Tags: Review Source Type: research
Gut microbiota-host lipid crosstalk in Alzheimer ’s disease: implications for disease progression and therapeutics
Trillions of intestinal bacteria in the human body undergo dynamic transformations in response to physiological and pathological changes. Alterations in their composition and metabolites collectively contribut... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 16, 2024 Category: Neurology Authors: Ya-Xi Luo, Ling-Ling Yang and Xiu-Qing Yao Tags: Review Source Type: research
Mitovesicles secreted into the extracellular space of brains with mitochondrial dysfunction impair synaptic plasticity
Hypometabolism tied to mitochondrial dysfunction occurs in the aging brain and in neurodegenerative disorders, including in Alzheimer ’s disease, in Down syndrome, and in mouse models of these conditions. We ha... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 14, 2024 Category: Neurology Authors: Pasquale D ’Acunzo, Elentina K. Argyrousi, Jonathan M. Ungania, Yohan Kim, Steven DeRosa, Monika Pawlik, Chris N. Goulbourne, Ottavio Arancio and Efrat Levy Tags: Research article Source Type: research
The concept of resilience to Alzheimer ’s Disease: current definitions and cellular and molecular mechanisms
Some individuals are able to maintain their cognitive abilities despite the presence of significant Alzheimer ’s Disease (AD) neuropathological changes. This discrepancy between cognition and pathology has been... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 8, 2024 Category: Neurology Authors: Luuk E. de Vries, Inge Huitinga, Helmut W. Kessels, Dick F. Swaab and Joost Verhaagen Tags: Review Source Type: research
An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders
Induced pluripotent stem cell-derived microglia (iMGL) represent an excellent tool in studying microglial function in health and disease. Yet, since differentiation and survival of iMGL are highly reliant on c... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 5, 2024 Category: Neurology Authors: Marie-France Dorion, Diana Casas, Irina Shlaifer, Moein Yaqubi, Peter Fleming, Nathan Karpilovsky, Carol X.-Q. Chen, Michael Nicouleau, Valerio E. C. Piscopo, Emma J. MacDougall, Aeshah Alluli, Taylor M. Goldsmith, Alexandria Schneider, Samuel Dorion, Nat Tags: Research article Source Type: research
Regulatory T cells limit age-associated retinal inflammation and neurodegeneration
Ageing is the principal risk factor for retinal degenerative diseases, which are the commonest cause of blindness in the developed countries. These conditions include age-related macular degeneration or diabet... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 5, 2024 Category: Neurology Authors: Mar ía Llorián-Salvador, Alerie G. de Fuente, Christopher E. McMurran, Amy Dashwood, James Dooley, Adrian Liston, Rosana Penalva, Yvonne Dombrowski, Alan W. Stitt and Denise C. Fitzgerald Tags: Research article Source Type: research
The endotoxin hypothesis of Alzheimer ’s disease
Lipopolysaccharide (LPS) constitutes much of the surface of Gram-negative bacteria, and if LPS enters the human body or brain can induce inflammation and act as an endotoxin. We outline the hypothesis here tha... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 1, 2024 Category: Neurology Authors: Guy C. Brown and Michael T. Heneka Tags: Review Source Type: research
HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases
This letter demonstrates the potential of novel cryptic proteins resulting from TAR DNA-binding protein 43 (TDP-43) dysfunction as markers of TDP-43 pathology in neurodegenerative diseases. (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 27, 2024 Category: Neurology Authors: Anna Calliari, Lillian M. Daughrity, Ellen A. Albagli, Paula Castellanos Otero, Mei Yue, Karen Jansen-West, Naeyma N. Islam, Thomas Caulfield, Bailey Rawlinson, Michael DeTure, Casey Cook, Neill R. Graff-Radford, Gregory S. Day, Bradley F. Boeve, David S. Tags: Letter to the Editor Source Type: research
Correction: Unravelling cell type-specific responses to Parkinson ’s Disease at single cell resolution
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 25, 2024 Category: Neurology Authors: Araks Martirosyan, Rizwan Ansari, Francisco Pestana, Katja Hebestreit, Hayk Gasparyan, Razmik Aleksanyan, Silvia Hnatova, Suresh Poovathingal, Catherine Marneffe, Dietmar R. Thal, Andrew Kottick, Victor J. Hanson-Smith, Sebastian Guelfi, William Plumbly, Tags: Correction Source Type: research
Correction: Blood –brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 22, 2024 Category: Neurology Authors: Qingyi Ma, Zhen Zhao, Abhay P. Sagare, Yingxi Wu, Min Wang, Nelly Chuqui Owens, Philip B. Verghese, Joachim Herz, David M. Holtzman and Berislav V. Zlokovic Tags: Correction Source Type: research
A partial Drp1 knockout improves autophagy flux independent of mitochondrial function
Dynamin-related protein 1 (Drp1) plays a critical role in mitochondrial dynamics. Partial inhibition of this protein is protective in experimental models of neurological disorders such as Parkinson ’s disease a... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 19, 2024 Category: Neurology Authors: Rebecca Z. Fan, Carolina Sportelli, Yanhao Lai, Said S. Salehe, Jennifer R. Pinnell, Harry J. Brown, Jason R. Richardson, Shouqing Luo and Kim Tieu Tags: Research article Source Type: research
Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid- β clearance in animal models of Alzheimer’s disease
Age-dependent accumulation of amyloid plaques in patients with sporadic Alzheimer ’s disease (AD) is associated with reduced amyloid clearance. Older microglia have a reduced ability to phagocytose amyloid, so ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 16, 2024 Category: Neurology Authors: Hyo Jung Shin, In Soo Kim, Seung Gyu Choi, Kayoung Lee, Hyewon Park, Juhee Shin, Dayoung Kim, Jaewon Beom, Yoon Young Yi, Deepak Prasad Gupta, Gyun Jee Song, Won-Suk Chung, C. Justin Lee and Dong Woon Kim Tags: Research article Source Type: research
APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward A β, through P2RY12
Microglia are highly dynamic cells that play a critical role in tissue homeostasis through the surveillance of brain parenchyma and response to cues associated with damage. Aging and APOE4 genotype are the strong... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 11, 2024 Category: Neurology Authors: Jordy Sepulveda, Jennifer Yejean Kim, Joseph Binder, Stefano Vicini and G. William Rebeck Tags: Research article Source Type: research
Updates on mouse models of Alzheimer ’s disease
Alzheimer ’s disease (AD) is the most common neurodegenerative disease in the United States (US). Animal models, specifically mouse models have been developed to better elucidate disease mechanisms and test the... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 11, 2024 Category: Neurology Authors: Michael Z. Zhong, Thomas Peng, Mariana Lemos Duarte, Minghui Wang and Dongming Cai Tags: Review Source Type: research
GBA1 inactivation in oligodendrocytes affects myelination and induces neurodegenerative hallmarks and lipid dyshomeostasis in mice
Mutations in the β-glucocerebrosidase (GBA1) gene do cause the lysosomal storage Gaucher disease (GD) and are among the most frequent genetic risk factors for Parkinson’s disease (PD). So far, studies on both neu... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 7, 2024 Category: Neurology Authors: Ilaria Gregorio, Loris Russo, Enrica Torretta, Pietro Barbacini, Gabriella Contarini, Giada Pacinelli, Dario Bizzotto, Manuela Moriggi, Paola Braghetta, Francesco Papaleo, Cecilia Gelfi, Enrico Moro and Matilde Cescon Tags: Research article Source Type: research
