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Contents of Molecular Oncology Volume 3Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Oncology)
Source: Molecular Oncology - November 5, 2009 Category: Cancer & Oncology Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Oncology)
Source: Molecular Oncology - November 5, 2009 Category: Cancer & Oncology Source Type: journals

Immunotherapy in the landscape of new targeted treatments for non-small cell lung cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Active immunotherapies and molecules targeting tyrosine kinase receptors both offer new avenues for the treatment of NSCLC. Furthermore, their combinations or their administration along with standard treatments enlarges the potential for clinical benefit. Moreover, the discovery of biomarkers predicting the response to these new therapies should allow a better selection of patients susceptible to optimally benefit from these treatments. In this paper, we review the most promising active immunotherapies, antibodies and small...
Source: Molecular Oncology - September 22, 2009 Category: Cancer & Oncology Authors: Catherine Gérard, Channa Debruyne Tags: Reviews Source Type: journals

Tailoring cancer therapy – Validating basic science with the ‘supertrial’Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A paradigm shift in research culture is needed in order to set up the large ambitious trials needed to make personalised medicine a reality. Emma Wilkinson talks to the experts about the hurdles they face and what needs to change. (Source: Molecular Oncology)
Source: Molecular Oncology - August 28, 2009 Category: Cancer & Oncology Authors: Emma Wilkinson Tags: News & Views Source Type: journals

Personal ProfilesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An overview of Personal Profiles can be found at http://www.moloncol.org. Anton Berns Director of Research, The Netherlands Cancer Institute. Professor of Experimental Genetics of Inherited Diseases, University of Amsterdam. (Source: Molecular Oncology)
Source: Molecular Oncology - August 7, 2009 Category: Cancer & Oncology Source Type: journals

Molecular profiling and characterization of luminal-like and basal-like in vivo breast cancer xenograft modelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The number of relevant and well-characterized cell lines and xenograft models for studying human breast cancer are few, and may represent a limitation for this field of research. With the aim of developing new breast cancer model systems for in vivo studies of hormone dependent and independent tumor growth, progression and invasion, and for in vivo experimental therapy studies, we collected primary mammary tumor specimens from patients, and implanted them in immunodeficient mice. Primary tumor tissue from 29 patients with breast cancer was implanted subcutaneously with matrigel in SCID mice, in the presence of co...
Source: Molecular Oncology - August 6, 2009 Category: Cancer & Oncology Authors: Anna Bergamaschi, Geir Olav Hjortland, Tiziana Triulzi, Therese Sørlie, Hilde Johnsen, Anne Hansen Ree, Hege Giercksky Russnes, Sigurd Tronnes, Gunhild M. Mælandsmo, Oystein Fodstad, Anne-Lise Borresen-Dale, Olav Engebraaten Tags: Papers Source Type: journals

Transcription factors down-stream of Ras as molecular indicators for targeting malignancies with oncolytic herpes virusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study, therefore, for the first time documents permissiveness of lymphoma cells to oncolytic herpes viruses and introduces ELK as a suitable factor for predicting tumor susceptibility to these novel anticancer agents. (Source: Molecular Oncology)
Source: Molecular Oncology - August 5, 2009 Category: Cancer & Oncology Authors: Tuba Esfandyari, Ayalew Tefferi, Anna Szmidt, Tommy Alain, Pawel Zwolak, Terra Lasho, Patrick W. Lee, Faris Farassati Tags: Papers Source Type: journals

Transforming growth-interacting factor (TGIF) regulates proliferation and differentiation of human myeloid leukemia cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Transforming growth-interacting factor (TGIF) is a homeobox transcriptional repressor that has been implicated in holoprosencephaly and various types of cancer. TGIF is expressed in hematopoietic stem cells and modulates TGF-β and retinoic acid (RA) signaling, both of which play an important role in hematopoiesis. We recently reported that TGIF's levels correlate inversely with survival in patients with acute myelogenous leukemia. Here we present the first direct evidence of a role for TGIF in myelopoiesis. We used short hairpin RNA interference to define the effects of TGIF knockdown on proliferation and differ...
Source: Molecular Oncology - August 5, 2009 Category: Cancer & Oncology Authors: Rizwan Hamid, Stephen J. Brandt Tags: Papers Source Type: journals

Contents of Molecular Oncology Volume 3Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Oncology)
Source: Molecular Oncology - July 31, 2009 Category: Cancer & Oncology Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Oncology)
Source: Molecular Oncology - July 31, 2009 Category: Cancer & Oncology Source Type: journals

Identification of c-Src tyrosine kinase substrates in platelet-derived growth factor receptor signalingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: c-Src non-receptor tyrosine kinase is an important component of the platelet-derived growth factor (PDGF) receptor signaling pathway. c-Src has been shown to mediate the mitogenic response to PDGF in fibroblasts. However, the exact components of PDGF receptor signaling pathway mediated by c-Src remain unclear. Here, we used stable isotope labeling with amino acids in cell culture (SILAC) coupled with mass spectrometry to identify Src-family kinase substrates involved in PDGF signaling. Using SILAC, we were able to detect changes in tyrosine phosphorylation patterns of 43 potential c-Src kinase substrates in PDGF ...
Source: Molecular Oncology - July 17, 2009 Category: Cancer & Oncology Authors: Ramars Amanchy, Jun Zhong, Rosa Hong, James H. Kim, Marjan Gucek, Robert N. Cole, Henrik Molina, Akhilesh Pandey Tags: Papers Source Type: journals

Putting Europe on the scientific mapEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The pursuit of excellence has been a dominant theme in the career of Fotis Kafatos, a distinguished malaria researcher, who is now taking his high standards forward in providing support for the very brightest young scientists in Europe, as part of his presidency of The European Research Council. (Source: Molecular Oncology)
Source: Molecular Oncology - July 13, 2009 Category: Cancer & Oncology Authors: Janet Fricker Tags: News & Views Source Type: journals

Re: Sam Loewenberg's article, “Cancer policy in the Obama administration”Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In order to make progress in cancer research in the coming years, it's important first to understand the greatest hurdles standing in the way of federal funding for cancer research. From a patient's perspective, the media, for one thing, does a very poor job of educating and serving the public about cancer issues. The media tends to cover cancer when it strikes a celebrity. The problem is that the coverage is all human interest, and sometimes assumes the character of a death watch. I heard a cable news anchor, who lost a sister-in-law to breast cancer, explains how her producers almost never wanted to do stories related to...
Source: Molecular Oncology - July 6, 2009 Category: Cancer & Oncology Authors: Matthew Dallek Tags: Letter to the Editor Source Type: journals

Ras/MAPK signaling from endomembranesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Signal transduction along the Ras/MAPK pathway has been generally thought to take place at the plasma membrane. It is now evident that the plasma membrane is not the only platform capable of Ras/MAPK signal induction. Fusion of Ras with green fluorescent protein and the development of genetically encoded fluorescent probes for Ras activation have revealed signaling events on a variety of intracellular membranes including endosomes, the Golgi apparatus and the endoplasmic reticulum. Thus, the Ras/MAPK pathway is spatially compartmentalized within cells and this may afford greater complexity of signal output. (Sour...
Source: Molecular Oncology - July 1, 2009 Category: Cancer & Oncology Authors: Nicole Fehrenbacher, Dafna Bar-Sagi, Mark Philips Tags: Reviews Source Type: journals

Endocytosis, signaling and cancer, much more than meets the eyeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Any encyclopedia definition of “Endocytosis” will include statements such as “eukaryotic cells use endocytosis to internalize plasma membrane, surface receptors and their bound ligands, nutrients, bacterial toxins, immunoglobulins, viruses, and various extracellular soluble molecules” (). In other words, the canonical view of endocytosis has, for a long time, been that of a process designed to bring nutrients and/or other types of molecules inside the cell and, at the same time, to regulate the composition of the plasma membrane. Of course, endocytosis does all of this, and more… much more. The approaches that ar...
Source: Molecular Oncology - July 1, 2009 Category: Cancer & Oncology Authors: Pier Paolo Di Fiore Tags: Preface Source Type: journals

Endocytosis and signalling: A meeting with mathematicsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Although endocytosis has traditionally been understood as a signal attenuation mechanism, an emerging view considers endocytosis as an integral part of signal propagation and processing. On the short time scale, trafficking of endocytic vesicles contributes to signal propagation from the surface to distant targets, with bi-directional communication between signalling and trafficking. Mathematical modelling helps combine the mechanistic, molecular knowledge with rigorous analysis of the complex output dynamics of endocytosis in time and space. Simulations reveal novel roles for endocytosis, including the control o...
Source: Molecular Oncology - June 28, 2009 Category: Cancer & Oncology Authors: Marc R. Birtwistle, Boris N. Kholodenko Tags: Reviews Source Type: journals

Endocytic proteins in the regulation of nuclear signaling, transcription and tumorigenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Accumulating evidence argues that many proteins governing membrane sorting during endocytosis participate also in nuclear signaling and transcriptional regulation, mostly by modulating the activity of various nuclear factors. Some adaptors and accessory proteins acting in clathrin-mediated internalization, as well as endosomal sorting proteins can undergo nuclear translocation and affect gene expression directly, while for others the effects may be more indirect. Although it is often unclear to what extent the endocytic and nuclear functions are interrelated, several of such proteins are implicated in the regulat...
Source: Molecular Oncology - June 21, 2009 Category: Cancer & Oncology Authors: Beata Pyrzynska, Iwona Pilecka, Marta Miaczynska Tags: Reviews Source Type: journals

Endocytosis and spatial restriction of cell signalingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Endocytosis and recycling are essential components of the wiring enabling cells to perceive extracellular signals and transduce them in a temporally and spatially controlled fashion, directly influencing not only the duration and intensity of the signaling output, but also their correct location. Here, we will discuss key experimental evidence that support how different internalization routes, the generation of diverse endomembrane platforms, and cycles of internalization and recycling ensure polarized compartmentalization of signals, regulating a number of physiological and pathologically-relevant processes in w...
Source: Molecular Oncology - June 18, 2009 Category: Cancer & Oncology Authors: Andrea Disanza, Emanuela Frittoli, Andrea Palamidessi, Giorgio Scita Tags: Reviews Source Type: journals

Autophagy in tumour suppression and promotionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Autophagy, a well-described cellular mechanism for lysosomal degradation of cytoplasmic content, has emerged as a tumour suppression pathway. Recent evidence indicates that the tumour suppressor function of autophagy is mediated by scavenging of damaged oxidative organelles, thereby preventing accumulation of toxic oxygen radicals that would cause genome instability. Paradoxically, however, in some cases autophagy can also promote the survival of cancer cells once tumours have developed. This is attributed to the ability of autophagy to promote cell survival under conditions of poor nutrient supply, as often face...
Source: Molecular Oncology - June 17, 2009 Category: Cancer & Oncology Authors: Andreas Brech, Terje Ahlquist, Ragnhild A. Lothe, Harald Stenmark Tags: Reviews Source Type: journals

At the crossroads of polarity, proliferation and apoptosis: The use of Drosophila to unravel the multifaceted role of endocytosis in tumor suppressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Endocytosis is an important regulator of cell–cell signaling and endocytic trafficking has been increasingly implicated in control of tumor suppression. Recent insights from Drosophila indicate that impairment of multiple trafficking steps which lead to receptor degradation can cause tumor formation in epithelial organs. These tumors are characterized by sustained activation of a number of mitogenic signaling pathways, and by subversion of epithelial polarity and the apoptotic response. Cooperation between such alterations, as well as tumor–host interactions, is also observed. The recapitulation of several ha...
Source: Molecular Oncology - June 17, 2009 Category: Cancer & Oncology Authors: Thomas Vaccari, David Bilder Tags: Reviews Source Type: journals

Endocytosis, asymmetric cell division, stem cells and cancer: Unus pro omnibus, omnes pro unoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Carcinogenesis can be initiated in adult stem cells, suggesting that tumours arise as a consequence of stem-cell dysfunction. In the fruitfly, cancer arises in stem cells that fail to undergo asymmetric cell division. In flies and mammals, a specific regulation of the endocytic trafficking machinery allows stem cells to self-renew and generate the differentiating cells required to form and maintain mature organs. We review recent findings suggesting that an understanding of the relationship between endocytosis, asymmetric cell division, stem cells and cancer will be crucial to unravel the cell biological basis of...
Source: Molecular Oncology - June 17, 2009 Category: Cancer & Oncology Authors: Maximilian Fürthauer, Marcos González-Gaitán Tags: Reviews Source Type: journals

Cancer policy in the Obama administrationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In his first address to a joint session of Congress, President Barack Obama said he would devote resources to find “a cure for cancer in our time.” While that may be political rhetoric, it signals a commitment, and specifically a dollar commitment, to research funding that had been missing in the Bush administration, where research budgets languished. Obama has promised to double research funding for cancer during his term. In his first budget, he proposed increasing cancer research funding to $6 billion, which is about a 15 percent increase over existing levels. It is unclear what will happen by the time Congress gets...
Source: Molecular Oncology - June 15, 2009 Category: Cancer & Oncology Authors: Samuel Loewenberg Tags: News & Views Source Type: journals

The role of protein synthesis in cell cycling and cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Cell cycling and protein synthesis are both key physiological tasks for cancer cells. Here we present a model for how the elongation phase of protein synthesis, governed by elongation factor 2 and elongation factor 2 kinase, both modulates and responds to cell cycling. Within this framework we also discuss survivin, a protein with both pro-mitotic and anti-apoptotic roles whose persistence in the cell is tied to protein synthesis due to its short half-life. Finally, we provide a brief overview of efforts of cancer researchers to target EF2 and EF2 kinase. (Source: Molecular Oncology)
Source: Molecular Oncology - June 12, 2009 Category: Cancer & Oncology Authors: Shai White-Gilbertson, David T. Kurtz, Christina Voelkel-Johnson Tags: Reviews Source Type: journals

Corrigendum to “Has the US Cancer Centre model been ‘successful’? Lessons for the European cancer community” [Mol. Oncol. 3 (2009) 192–203]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An unfortunate error occurred in the acknowledgement given in the footnote on page 192. The correct acknowledgement should read: This work was supported by European Cancer Research Managers Foundation and funded by a grant from WHO International Agency for Research into Cancer (IARC). The MS Excel macros used to perform the geographical analysis of the papers were written by Dr. Philip Roe. Prof. Grant Lewison, Evalumetrics and University College London, UK provided the analysis for Figures 2, 3 and 4. Part of this research was conducted whilst RS was at Cancer Research UK. (Source: Molecular Oncology)
Source: Molecular Oncology - June 8, 2009 Category: Cancer & Oncology Authors: Richard Sullivan Tags: Corrigendum Source Type: journals

Review on early technology assessments of nanotechnologies in oncologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Nanotechnology is expected to play an increasingly important role in the diagnostics, prognostics, and management of targeted cancer treatments. While papers have described promising results for nanotechnology in experimental settings, the translation of fundamental research into clinical applications has yet to be widely adopted. In future, policy makers will need to anticipate new developments for clinical implementation and introduce technology assessments. Here we present an overview of the literature on the technology assessments that have already been undertaken on early stage nanotechnology in cancer care,...
Source: Molecular Oncology - June 8, 2009 Category: Cancer & Oncology Authors: Valesca P. Retèl, Marjan J.M. Hummel, Wim H. van Harten Tags: Reviews Source Type: journals

Contents of Molecular Oncology Volume 3Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Oncology)
Source: Molecular Oncology - May 19, 2009 Category: Cancer & Oncology Source Type: journals

Conference calendarEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Oncology)
Source: Molecular Oncology - May 19, 2009 Category: Cancer & Oncology Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Oncology)
Source: Molecular Oncology - May 19, 2009 Category: Cancer & Oncology Source Type: journals

Characterizing DNA methylation patterns in pancreatic cancer genomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We performed a global methylation profiling assay on 1505 CpG sites across 807 genes to characterize DNA methylation patterns in pancreatic cancer genome. We found 289 CpG sites that were differentially methylated in normal pancreas, pancreatic tumors and cancer cell lines. We identified 23 and 35 candidate genes that are regulated by hypermethylation and hypomethylation in pancreatic cancer, respectively. We also identified candidate methylation markers that alter the expression of genes critical to gemcitabine susceptibility in pancreatic cancer. These results indicate that aberrant DNA methylation is a frequen...
Source: Molecular Oncology - May 8, 2009 Category: Cancer & Oncology Authors: Aik Choon Tan, Antonio Jimeno, Steven H. Lin, Jenna Wheelhouse, Fonda Chan, Anna Solomon, N.V. Rajeshkumar, Belen Rubio-Viqueira, Manuel Hidalgo Tags: Papers Source Type: journals

Personal ProfilesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An overview of Personal Profiles can be found at http://www.moloncol.org. Jiri Bartek (Source: Molecular Oncology)
Source: Molecular Oncology - April 22, 2009 Category: Cancer & Oncology Source Type: journals

An interview with Alexander EggermontEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Taking a “helicopter view of oncology” has become the main role of Alexander Eggermont, the first president of the newly reformed European CanCer Organisation (ECCO), who is the driving force behind a new initiative to provide European governments with a “rationale” voice on oncology. (Source: Molecular Oncology)
Source: Molecular Oncology - April 20, 2009 Category: Cancer & Oncology Authors: Janet Fricker Tags: News & Views Source Type: journals

Full sequencing of TP53 identifies identical mutations within in situ and invasive components in breast cancer suggesting clonal evolutionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In breast cancer, previous studies have suggested that somatic TP53 mutations are likely to be an early event. However, there are controversies regarding the cellular origin and linear course of breast cancer. The purpose of this study was to investigate tumor evolution in breast cancer by analyzing TP53 mutation status in tumors from various stages of the disease. The entire coding sequence of TP53 was sequenced in a cohort of pure ductal carcinoma in situ (DCIS), pure invasive cancer (≤15mm) and mixed lesions (i.e. invasive cancer with an in situ component). Of 118 tumor samples, 19 were found to harbor a TP5...
Source: Molecular Oncology - April 17, 2009 Category: Cancer & Oncology Authors: Wenjing Zhou, Aslaug A. Muggerud, Phuong Vu, Eldri U. Due, Therese Sørlie, Anne-Lise Børresen-Dale, Fredrik Wärnberg, Anita Langerød Tags: Papers Source Type: journals

Has the US Cancer Centre model been ‘successful’? Lessons for the European cancer communityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The US model of Cancer Centres created by the National Cancer Act in 1971 has been one of the most tried and tested models of organised disease-specific scientific endeavors in the world. With many countries, particularly those in Europe now looking to develop the research arms of their National Cancer Control Programmes through the development of similar Cancer Centres the time is correct to consider the success and limitations of the US effort to date. Here we described the salient features of both US Cancer Centres and Networks, including their funding and evaluation with socio-political analysis on the learni...
Source: Molecular Oncology - April 6, 2009 Category: Cancer & Oncology Authors: Richard Sullivan Tags: Science Policy Source Type: journals

Contents of Molecular Oncology Volume 3Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Oncology)
Source: Molecular Oncology - April 1, 2009 Category: Cancer & Oncology Source Type: journals

Conference calendarEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Oncology)
Source: Molecular Oncology - April 1, 2009 Category: Cancer & Oncology Source Type: journals

Role of genetic polymorphisms and ovarian cancer susceptibilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The value of identifying women with an inherited predisposition to epithelial ovarian cancer has become readily apparent with the identification of the BRCA1, and BRCA2 genes. Women who inherit a deleterious mutation in either of these genes have a very high lifetime risk of ovarian cancer (10–60%) and to some extent, increased risks of fallopian tube and peritoneal cancer. These highly lethal cancers are almost completely prevented by prophylactic salpingoophorectomy. BRCA1/2 mutation testing has become the accepted standard of care in families with a strong history of breast and/or ovarian cancer. This approa...
Source: Molecular Oncology - April 1, 2009 Category: Cancer & Oncology Authors: Peter A. Fasching, Simon Gayther, Leigh Pearce, Joellen M. Schildkraut, Ellen Goode, Falk Thiel, Georgia Chenevix-Trench, Jenny Chang-Claude, Shan Wang-Gohrke, Susan Ramus, Paul Pharoah, Andrew Berchuck, for the OCAC (Ovarian Cancer Association Consortium Tags: Thematic Issue Reviews Source Type: journals

Intercepting pelvic cancer in the distal fallopian tube: Theories and realitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The pathogenesis of high-grade serous carcinoma of the ovary has come into sharper focus as closer attention has been paid to the earlier phases of this disease. The study of patients with BRCA mutation has been of particular value, in as much as the examination of prophylactic salpingo-oophorectomies will reveal an early cancer in approximately 5% of individuals. Recently studies have shown that about 80% of these early carcinomas originate in the distal fallopian tube. This review summarizes the recent data supporting the distal fallopian tube as an important site for serous carcinogenesis, stressing both the p...
Source: Molecular Oncology - April 1, 2009 Category: Cancer & Oncology Authors: Christopher P. Crum Tags: Thematic Issue Reviews Source Type: journals

Large-scale genomic analysis of ovarian carcinomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Epithelial ovarian cancers are typified by frequent genomic aberrations that have been difficult to unravel. Recently, high-resolution array technologies have provided the first glimpse of the remarkable complexity of these aberrations with some ovarian cancers containing hundreds of copy number breakpoints, micro-deletions and amplifications. Many of these alterations contain cancer-related genes suggesting that the majority is disease-associated and not just the product of random genomic instability. Future developments such as next-generation sequencing and integrated analysis of data from multiple array platf...
Source: Molecular Oncology - April 1, 2009 Category: Cancer & Oncology Authors: Kylie L. Gorringe, Ian G. Campbell Tags: Thematic Issue Reviews Source Type: journals

Molecular profiles of hereditary epithelial ovarian cancers and their implications for the biology of this diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: BRCA1 and BRCA2 germline mutations account for the majority of hereditary ovarian cancers and comprise 10% of total cases. Ovarian cancers arising from these mutations exhibit both overlapping and distinct clinical and molecular features. The expression profiles of sporadic ovarian cancers show similarities to those of BRCA1 and BRCA2-related tumors suggesting that BRCA-related pathways may be involved in their development as well. The purpose of this review is to consider the available data on ovarian cancers in the context of other investigations of BRCA-related transcriptional alterations, and highlight areas ...
Source: Molecular Oncology - April 1, 2009 Category: Cancer & Oncology Authors: Amir A. Jazaeri Tags: Thematic Issue Reviews Source Type: journals

The Contribution of BRCA1 and BRCA2 to Ovarian CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Germline mutations of the BRCA1 and BRCA2 genes confer a high life-time risk of ovarian cancer. They represent the most significant and well characterised genetic risk factors so far identified for the disease. The frequency with which BRCA1/2 mutations occur in families containing multiple cases of ovarian cancer or breast and ovarian cancer, and in population-based ovarian cancer series varies geographically and between different ethnic groups. There are differences in the frequency of common mutations and in the presence of specific founder mutations in different populations. BRCA1 and BRCA2 are responsible fo...
Source: Molecular Oncology - April 1, 2009 Category: Cancer & Oncology Authors: Susan J. Ramus, Simon A. Gayther Tags: Thematic Issue Reviews Source Type: journals

Hereditary ovarian carcinoma: Heterogeneity, molecular genetics, pathology, and managementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Hereditary ovarian cancer accounts for at least 5% of the estimated 22,000 new cases of this disease during 2009. During this same time, over 15,000 will die from malignancy ascribed to ovarian origin. The bulk of these hereditary cases fits the hereditary breast–ovarian cancer syndrome, while virtually all of the remainder will be consonant with the Lynch syndrome, disorders which are autosomal dominantly inherited. Advances in molecular genetics have led to the identification of BRCA1 and BRCA2 gene mutations which predispose to the hereditary breast–ovarian cancer syndrome, and mutations in mismatch repair...
Source: Molecular Oncology - April 1, 2009 Category: Cancer & Oncology Authors: Henry T. Lynch, Murray Joseph Casey, Carrie L. Snyder, Chhanda Bewtra, Jane F. Lynch, Matthew Butts, Andrew K. Godwin Tags: Thematic Issue Reviews Source Type: journals

Thematic issue on the molecular biology of hereditary ovarian cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ovarian cancer is a complex heterogeneous disease defined by histopathology, somatic molecular genetic attributes, and hereditary context. About 90% of ovarian cancers are of the epithelial type and within this group an estimated 5% are attributed to the inheritance of a highly penetrant allele that confers a significant life-time risk for developing ovarian cancer. In most developed countries, epithelial ovarian cancer is the fifth most common cause of death and is the most lethal form of gynecologic malignancy. Regardless of hereditary context, most cases are diagnosed at an advanced disease stage, where it has spread to...
Source: Molecular Oncology - April 1, 2009 Category: Cancer & Oncology Authors: Patricia N. Tonin Tags: Preface Source Type: journals

The Bayh–Dole Act: A model for promoting research translation?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The Bayh-Dole Act of 1980 was passed with the intention of promoting research into cancer and other diseases by providing institutions and researchers with a commercial incentive, even though much of their work was publicly funded. Now, many are questioning whether the system has worked as promised and some warn it may be jeopardizing the pursuit of science with no direct market relevance. (Source: Molecular Oncology)
Source: Molecular Oncology - April 1, 2009 Category: Cancer & Oncology Authors: Samuel Loewenberg Tags: News & Views Source Type: journals

Profile: Professor John MendelsohnEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lessons learnt from Hurricane Ike last autumn are now guiding John Mendelsohn in his management of the largest US cancer institute in the current financial down turn. “We face critical financial pressures due to decreasing federal research support, cutbacks in Medicaid and Medicare, reduced philanthropic gifts, and increases in expenses for medically indigent patients,” says Mendelsohn, president of the University of Texas M. D. Anderson Cancer Center. “We weathered the hurricane well, based on careful preparation and a spirit of dedication and teamwork when the storm arrived. It's in the same spirit we're planning t...
Source: Molecular Oncology - April 1, 2009 Category: Cancer & Oncology Authors: Janet Fricker Tags: News & Views Source Type: journals

Thematic IssuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Beginning with this issue Molecular Oncology introduces a new type of publication – Thematic Issues – that are intended to highlight a particular area of cancer research and to give an overview of where that specific field stands today and where it is heading to in the near future. The rational for introducing this new type of publication was prompted largely by the staggering expansion both in knowledge and technology in various areas of cancer research. These developments call for a forum in which new discoveries and future perspectives are integrated and presented in a timely manner. (Source: Molecular Oncology)
Source: Molecular Oncology - April 1, 2009 Category: Cancer & Oncology Authors: Julio E. Celis Tags: Editorial Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Oncology)
Source: Molecular Oncology - April 1, 2009 Category: Cancer & Oncology Source Type: journals

Ectopic expression of plasma membrane targeted subunits of the Ndc80-complex as a tool to study kinetochore biochemistryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Genomic stability depends on the normal function of the kinetochore, a multi-protein assemblage, which consists of over 80 molecules including both constitutive and transiently binding components. Information regarding the spatial–temporal assembly of kinetochore subcomplexes is often limited by technical difficulties in their isolation. To study kinetochore subcomplex formation, we targeted separately Hec1 and Spc24, two subunits of the Ndc80 kinetochore compilation, to the plasma membrane by fusing them with the amino-terminal palmitoylation and myristoylation (pm) sequence of the receptor tyrosine kinase Fyn...
Source: Molecular Oncology - March 5, 2009 Category: Cancer & Oncology Authors: Tim H. Holmström, Jonathan Rehnberg, Leena J. Ahonen, Marko J. Kallio Tags: Technical Note Source Type: journals

Discovery of epitopes for targeting the human epidermal growth factor receptor 2 (HER2) with antibodiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Antibodies have become valuable therapeutic agents for targeting of extracellular proteins in various diseases, including cancer, autoimmunity and cardiovascular disorders. For breast cancer, antibodies targeting the human HER2 have been shown to result in cell growth inhibition both in vitro and in patients with breast tumors. There is evidence to suggest that targeting multiple HER2 epitopes may result in increased growth inhibition making it interesting to find antibodies targeting new epitopes. Here, we report on a new scheme to discover antibodies directed to new epitopes using the extracellular domain of th...
Source: Molecular Oncology - February 13, 2009 Category: Cancer & Oncology Authors: Johan Rockberg, Jochen M. Schwenk, Mathias Uhlén Tags: Papers Source Type: journals

Molecular characterization of apocrine carcinoma of the breast: Validation of an apocrine protein signature in a well-defined cohortEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Invasive apocrine carcinomas (IACs), as defined by morphological features, correspond to 0.3–4% of all invasive ductal carcinomas (IDC), and despite the fact that they are histologically distinct from other breast lesions there are currently no standard molecular criteria available for their diagnosis and no unequivocal information as to their prognosis. In an effort to address these concerns we have been using protein expression profiling technologies in combination with mass spectrometry and immunohistochemistry (IHC) to discover specific biomarkers that could allow us to molecularly characterize these lesion...
Source: Molecular Oncology - February 13, 2009 Category: Cancer & Oncology Authors: Julio E. Celis, Teresa Cabezón, José M.A. Moreira, Pavel Gromov, Irina Gromova, Vera Timmermans-Wielenga, Takuji Iwase, Futoshi Akiyama, Naoko Honma, Fritz Rank Tags: Papers Source Type: journals

Neurotensin signaling induces intracellular alkalinization and interleukin-8 expression in human pancreatic cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Pancreatic adenocarcinomas express neurotensin receptors in up to 90% of cases, however, their role in tumor biology and as a drug target is not clear. In the present study, a stable neurotensin (NT) analog induced intracellular calcium release and intracellular alkalinization in BxPC-3 and PANC-1 pancreatic cancer cells that was abolished by inhibitors of NT receptor (NTR) and sodium–proton exchanger 1 (NHE1), amiloride and SR 142948, respectively. Activation of NHE1 involved increased phosphorylation of dimethylfumarate-sensitive mitogen- and stress-activated kinase 1/2 (MSK1/2). NTR signaling appears to prom...
Source: Molecular Oncology - February 12, 2009 Category: Cancer & Oncology Authors: Ulrike Olszewski, Gerhard Hamilton Tags: Papers Source Type: journals