Molecular and Cellular Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Valproate decreases transgenerationally blood pressure by affecting thyrotropin-releasing hormone promoter DNA methylation and gene expression in spontaneously hypertensive rat
Mol Cell Biochem. 2024 Apr 17. doi: 10.1007/s11010-024-05001-4. Online ahead of print.ABSTRACTCentral TRH, a neuropeptide, is involved in cardiovascular regulation. We demonstrated that the overexpression of diencephalic TRH (dTRH) in SHR rats can be prevented by antisense treatment, normalizing blood pressure (BP). Valproate (VPA) is an inhibitor of histone deacetylases (HDAC) which modulates gene expression through epigenetic modifications such as DNA methylation.AIMS: Study the role of HDAC inhibition in the regulation of dTRH gene expression and its effect on the pathogenesis of hypertension.MAIN METHODS: We treated 7-...
Source: Molecular and Cellular Biochemistry - April 17, 2024 Category: Biochemistry Authors: Mar ía S Landa Mariano L Schuman Maia Aisicovich Ludmila S Peres Diaz Mariela M Gironacci Silvia I Garc ía Carlos J Pirola Source Type: research

The mechanisms of exercise improving cardiovascular function by stimulating Piezo1 and TRP ion channels: a systemic review
Mol Cell Biochem. 2024 Apr 16. doi: 10.1007/s11010-024-05000-5. Online ahead of print.ABSTRACTMechanosensitive ion channels are widely distributed in the heart, lung, bladder and other tissues, and plays an important role in exercise-induced cardiovascular function promotion. By reviewing the PubMed databases, the results were summarized using the terms "Exercise/Sport", "Piezo1", "Transient receptor potential (TRP)" and "Cardiovascular" as the keywords, 124-related papers screened were sorted and reviewed. The results showed that: (1) Piezo1 and TRP channels play an important role in regulating blood pressure and the deve...
Source: Molecular and Cellular Biochemistry - April 16, 2024 Category: Biochemistry Authors: Xinyan Duan Renhan Liu Yue Xi Zhenjun Tian Source Type: research

STAT3 mediates ECM stiffness-dependent progression in ovarian cancer
Mol Cell Biochem. 2024 Apr 16. doi: 10.1007/s11010-024-04991-5. Online ahead of print.ABSTRACTThe treatment of ovarian cancer remains a medical challenge and its malignant progression is connected with obvious changes in both tissue and cell stiffness. However, the accurate mechanical-responsive molecules and mechanism remains unclear in ovarian cancer. Based on our previous results combined with the crucial regulatory role of STAT3 in the malignant progression of various cancer types, we want to investigate the relationship between STAT3 and matrix stiffness in ovarian cancer and further explore the potential mechanisms. ...
Source: Molecular and Cellular Biochemistry - April 16, 2024 Category: Biochemistry Authors: Sun Chenchen Qian Xueqian Lu Yahui Yuan Yi Zhang Hui Bai Lanning Cheng Min Han Yangyang Source Type: research

A crazy trio in Parkinson's disease: metabolism alteration, α-synuclein aggregation, and oxidative stress
Mol Cell Biochem. 2024 Apr 16. doi: 10.1007/s11010-024-04985-3. Online ahead of print.ABSTRACTParkinson's disease (PD) is an aging-associated neurodegenerative disorder, characterized by the progressive loss of dopaminergic neurons in the pars compacta of the substantia nigra and the presence of Lewy bodies containing α-synuclein within these neurons. Oligomeric α-synuclein exerts neurotoxic effects through mitochondrial dysfunction, glial cell inflammatory response, lysosomal dysfunction and so on. α-synuclein aggregation, often accompanied by oxidative stress, is generally considered to be a key factor in PD pathology...
Source: Molecular and Cellular Biochemistry - April 16, 2024 Category: Biochemistry Authors: Sheng Li Yanbing Liu Sen Lu Jiayi Xu Xiaokun Liu Di Yang Yuxuan Yang Lin Hou Ning Li Source Type: research

Retraction Note to: Expression patterns of AMP-deaminase isozymes in human hepatocellular carcinoma (HCC)
Mol Cell Biochem. 2024 Apr 16. doi: 10.1007/s11010-024-05011-2. Online ahead of print.NO ABSTRACTPMID:38625516 | DOI:10.1007/s11010-024-05011-2 (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - April 16, 2024 Category: Biochemistry Authors: Magdalena Szyd łowska Anna Roszkowska Source Type: research

Crosstalk between lipid metabolism and EMT: emerging mechanisms and cancer therapy
Mol Cell Biochem. 2024 Apr 15. doi: 10.1007/s11010-024-04995-1. Online ahead of print.ABSTRACTLipids are the key component of all membranes composed of a variety of molecules that transduce intracellular signaling and provide energy to the cells in the absence of nutrients. Alteration in lipid metabolism is a major factor for cancer heterogeneity and a newly identified cancer hallmark. Reprogramming of lipid metabolism affects the diverse cancer phenotypes, especially epithelial-mesenchymal transition (EMT). EMT activation is considered to be an essential step for tumor metastasis, which exhibits a crucial role in the biol...
Source: Molecular and Cellular Biochemistry - April 15, 2024 Category: Biochemistry Authors: Zaheer Ud Din Bai Cui Cenxin Wang Xiaoyu Zhang Arshad Mehmood Fei Peng Quentin Liu Source Type: research

Retraction Note: The importance of vitamin D in the diagnosis and treatment of adenomyosis
Mol Cell Biochem. 2024 Apr 13. doi: 10.1007/s11010-024-05007-y. Online ahead of print.NO ABSTRACTPMID:38613639 | DOI:10.1007/s11010-024-05007-y (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - April 13, 2024 Category: Biochemistry Authors: Rymgul S Moldassarina Gulshat K Manabayeva Zhansulu Ye Akylzhanova Azima M Rashidova Source Type: research

STING agonist, SMA-2, inhibits clear cell renal cell carcinoma through improving tumor microenvironment
Mol Cell Biochem. 2024 Apr 9. doi: 10.1007/s11010-024-04970-w. Online ahead of print.ABSTRACTClear cell renal cell carcinoma (ccRCC) is the most prevalent and lethal subtype of kidney cancer, patients with ccRCC usually have very poor prognosis and short survival. Therefore, it is urgent to develop more effective therapeutics or medications to suppress ccRCC progression. Here, we demonstrated that STING agonist, MSA-2 significantly inhibits tumor progress and prolongs the survival of ccRCC mice by promoting cytokines secretion. Moreover, MSA-2 triggered the trafficking and infiltration of CD8+ T cells, supported by the gen...
Source: Molecular and Cellular Biochemistry - April 9, 2024 Category: Biochemistry Authors: Wei Wang Fengqing Zhang Yan Hu Guangming Liu Source Type: research

Autosis: a new form of cell death in myocardial ischemia-reperfusion injury
This article describes the characteristics of autosis, autophagic cell death, and the relationship between autophagic cell death and autosis; reviews the mechanism of autosis in MIRI; and discusses its clinical significance.PMID:38594455 | DOI:10.1007/s11010-024-04988-0 (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - April 9, 2024 Category: Biochemistry Authors: Xiaoting Yang Hui Wu Gang Zhou Dong Zhang Qingzhuo Yang Yanfang Liu Yi Li Source Type: research