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Subacute dopa-responsive parkinsonism after successful surgical treatment of aqueductal stenosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Movement Disorders)
Source: Movement Disorders - November 13, 2009 Category: Neurology Authors: Kiyoka Kinugawa, Emmanuel Itti, Jean-Francois Lepeintre, Ivan Mari, Virginie Czernecki, Francoise Heran, Stephane Clemenceau, Marie Vidailhet, Roze Emmanuel Source Type: journals

Levodopa response in early Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To further characterize the short-term levodopa response in early PD, we performed a retrospective analysis of the ELLDOPA study which randomized 361 early PD subjects to placebo, levodopa 150, 300, or 600 mg/day. We evaluated change in UPDRS motor scores (UPDRSm) from baseline to weeks 9 and 24, and identified changes in UPDRSm that best discriminated treatment with levodopa from placebo. Linear regressions were used to determine associations between baseline characteristics and changes in UPDRSm. Mean percent improvement in UPDRSm in levodopa-treated subjects was greater than that for placebo-treated subjects (27.4% vs. ...
Source: Movement Disorders - November 11, 2009 Category: Neurology Authors: Robert A. Hauser, Peggy Auinger, David Oakes, on behalf of the Parkinson Study Group Source Type: journals

Role of LINGO1 polymorphisms in Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study on LINGO1-variants in PD argues against a major role of LINGO1 gene variations for PD. © 2009 Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 11, 2009 Category: Neurology Authors: Dietrich Haubenberger, Christoph Hotzy, Walter Pirker, Regina Katzenschlager, Thomas Brücke, Fritz Zimprich, Eduard Auff, Alexander Zimprich Source Type: journals

Idiopathic spinal myoclonus: A clinical and neurophysiological assessment of a movement disorder of uncertain originEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we looked for evidence of a BP in a cohort of patients with idiopathic SM. A clinical and neurophysiological assessment of 20 patients affected by idiopathic SM was performed. A video EEG-EMG multichannel recording was performed in each patient to detect BP. An expert neurophysiologist (PB) reviewed the BP recordings and divided them into those showing a definite, possible, and no BP. A clinical assessment of the videoed movements was performed by two neurologists expert in movement disorders (KB and MJE) who indicated if the movements were compatible with organic or psychogenic myoclonus. A definite or poss...
Source: Movement Disorders - November 11, 2009 Category: Neurology Authors: Marcello Esposito, Mark J. Edwards, Kailash P. Bhatia, Peter Brown, Carla Cordivari Source Type: journals

Theory of mind in Parkinson's disease and related basal ganglia disorders: A systematic reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Theory of mind (ToM), defined as the ability to infer other people's mental states, is a crucial prerequisite of human social interaction and a major topic of interest in the recent neuroscientific research. It has been proposed that ToM is mediated by a complex neuroanatomical network that includes the medial prefrontal cortex, the anterior gyrus cinguli, the sulcus temporalis superior, the temporal poles, and the amygdala. Various neurological and psychiatric diseases are accompanied by aspects of dysfunctional ToM processing. In this review, the association between basal ganglia, involved in the organization of complex ...
Source: Movement Disorders - November 11, 2009 Category: Neurology Authors: Maren Elisabeth Bodden, Richard Dodel, Elke Kalbe Source Type: journals

Clinical follow up of pathological gambling in Parkinson's disease in the West Scotland studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Movement Disorders)
Source: Movement Disorders - November 11, 2009 Category: Neurology Authors: Graeme J.A. Macphee, Claire Copeland, David Stewart, Katherine Grosset, Donald G. Grosset Source Type: journals

Interruption of deep brain stimulation of the globus pallidus in primary generalized dystoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study describes the course of dystonia during a 48 hours period without stimulation followed by a 24 hours period after turning ON the stimulator. 14 patients with generalized dystonia treated with bilateral GP DBS for 3 years or more were recruited. Blinded video-based analysis was performed using Burke-Fahn-Marsden scale at (1) baseline (ON stimulation), (2) up to 48 hours after the stimulator was turned OFF, and (3) 24 hours after the stimulator was turned ON. 13 patients completed the 48 hours OFF-stimulation period. The dystonia movement score progressively worsened from 24.3 ± 13.9 at baseline to 48.9 ± 19.8 a...
Source: Movement Disorders - November 11, 2009 Category: Neurology Authors: David Grabli, Claire Ewenczyk, Maria-Clara Coelho-Braga, Christelle Lagrange, Valerie Fraix, Philippe Cornu, Alim-Louis Benabid, Marie Vidailhet, Pierre Pollak Source Type: journals

A comparison of treatment thresholds in two large Parkinson's disease clinical trial cohortsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism (DATATOP) and Parkinson Research Examination of CEP-1347 Trial (PRECEPT) were two clinical trials of potential disease-modifying agents for Parkinson's disease that used the time to reaching disability sufficient to require dopaminergic therapy as the primary endpoint. To compare the thresholds for initiating dopaminergic treatment for Parkinson's disease between the two studies, conducted fifteen years apart. Baseline and 12-month endpoint characteristics for subjects in the placebo arms of the two studies were compared. DATATOP placebo subjects had slightly hi...
Source: Movement Disorders - November 11, 2009 Category: Neurology Authors: Connie Marras, Anthony E. Lang, Shirley W. Eberly, David Oakes, Stanley Fahn, Steven R. Schwid, Christopher Hyson, Ira Shoulson, of the Parkinson Study Group DATATOP and PRECEPT investigators Source Type: journals

Cognitive impulsivity in Parkinson's disease patients: Assessment and pathophysiologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Impulsivity may be induced by therapeutic interventions (dopamine replacement therapies and sub-thalamic nucleus (STN) stimulation) in patients with Parkinson's disease (PD). The present review has two goals. First, to describe the most frequently encountered facets of cognitive impulsivity and to stress the links between cognitive impulsivity and aspects such as reward-related decision making, risk-taking, and time-processing in healthy population. The most widely used related cognitive impulsivity paradigms are presented. Second, to review the results of studies on cognitive impulsivity in healthy volunteers and in patie...
Source: Movement Disorders - November 11, 2009 Category: Neurology Authors: Gabriel Robert, Dominique Drapier, Marc Verin, Bruno Millet, Jean-Philippe Azulay, Olivier Blin Source Type: journals

Validation of self-report depression rating scales in Huntington's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to assess the criterion validity of three self-report measures of depression in a sample of patients with Huntington's disease (HD). Fifty patients with HD completed the Beck Depression Inventory-II (BDI-II), the Hospital Anxiety and Depression Scale (HADS), and the Depression Intensity Scale Circles (DISCs). Current psychiatric status was assessed using the schedules for clinical assessment in neuropsychiatry (SCAN), and ICD-10 diagnosis was used as the gold standard. Receiver operating characteristics (ROC) curves were obtained and the sensitivity, specificity, positive, and negative predictive ...
Source: Movement Disorders - November 11, 2009 Category: Neurology Authors: Jennifer De Souza, Lisa A. Jones, Hugh Rickards Source Type: journals

Comparing bromocriptine effects with levodopa effects on bladder function in Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To evaluate the effects of bromocriptine on bladder function in Parkinson's disease (PD) patients and compare these effects with those of (L-dopa). We recruited 8 patients with PD. Urodynamic study (UDS) was performed before and 1 hour after administering 100 mg L-dopa/decarboxylase inhibitor (DCI) and 2.5 hours after administering 7.5 mg bromocriptine. After the bromocriptine administration, urinary urgency aggravated. UDS revealed a decreased bladder volume at which detrusor overactivity (DO) was initiated, a decreased bladder volume at first sensation of bladder filling (FSV) (P < 0.05), an increased maximum Watts Facto...
Source: Movement Disorders - November 11, 2009 Category: Neurology Authors: Tomoyuki Uchiyama, Ryuji Sakakibara, Tatsuya Yamamoto, Takashi Ito, M Chiharu Yamaguchi, Yusuke Awa, Masashi Yano, Mitsuru Yanagisawa, Makoto Kobayashi, Yoshinori Higuchi, Tomohiko Ichikawa, Tomonori Yamanishi, Takamichi Hattori, Satoshi Kuwabara Source Type: journals

Apathy may herald cognitive decline and dementia in Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Apathy is usually defined as a lack of motivation. It may occur as part of another disorder (notably depression and dementia) or as an isolated syndrome. In Parkinson's disease (PD), apathy is common and several studies have reported an association between this condition and more severe cognitive symptoms, such as executive dysfunction. However, this association has not been thoroughly investigated. The aim of this study (in nondepressed, nondemented PD patients) was to examine whether or not cognitive decline and/or dementia occurred more frequently in apathetic subjects than in nonapathetic subjects. Forty consecutive PD...
Source: Movement Disorders - November 11, 2009 Category: Neurology Authors: Kathy Dujardin, Pascal Sockeel, Marie Delliaux, Alain Destée, Luc Defebvre Source Type: journals

Identification of a novel THAP1 mutation at R29 amino-acid residue in sporadic patients with early-onset dystoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Movement Disorders)
Source: Movement Disorders - November 11, 2009 Category: Neurology Authors: Coro Paisán-Ruiz, Javier Ruiz-Martinez, Marta Ruibal, Kin Y. Mok, Begona Indakoetxea, Ana Gorostidi, José F. Martí Massó Source Type: journals

Stereotypical hand movements in 144 subjects with Rett syndrome from the population-based Australian databaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Stereotypic hand movements are a feature of Rett Syndrome but few studies have observed their nature systematically. Video data in familiar settings were obtained on subjects (n = 144) identified from an Australian population-based database. Hand stereotypies were demonstrated by most subjects (94.4%), 15 categories were observed and midline wringing was seen in approximately 60% of subjects. There was a median of two stereotypies per subject but this number decreased with age. Clapping and mouthing of hands were more prevalent in girls younger than 8 years and wringing was more prevalent in women 19 years or older. Clappi...
Source: Movement Disorders - November 11, 2009 Category: Neurology Authors: Philippa Carter, Jenny Downs, Ami Bebbington, Simon Williams, Peter Jacoby, Walter E. Kaufmann, Helen Leonard Source Type: journals

A comparison of gray and white matter density in patients with Parkinson's disease dementia and dementia with Lewy bodies using voxel-based morphometryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite clinical and neuropsychological similarities between Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB), recent studies have demonstrated that structural and pathological changes are more severe in DLB than in PDD. We used voxel-based morphometry using a 3-T MRI scanner to compare gray and white matter densities in 20 patients with probable PDD and 18 patients with probable DLB, who had similar overall severity of dementia and similar demographic characteristics. The gray matter density was significantly decreased in the left occipital, parietal, and striatal areas in patients with DLB compared ...
Source: Movement Disorders - November 11, 2009 Category: Neurology Authors: Ji E. Lee, Bosuk Park, Sook K. Song, Young H. Sohn, Hae-Jeong Park, Phil Hyu Lee Source Type: journals

HIV-associated parkinsonism with levodopa-induced dyskinesia and response to highly-active antiretroviral therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Movement Disorders)
Source: Movement Disorders - November 11, 2009 Category: Neurology Authors: Christopher Kobylecki, Monty A. Silverdale, Anoop Varma, Jeremy P.R. Dick, Mark W. Kellett Source Type: journals

Mutation screening of the DYT6/THAP1 gene in ItalyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mutations in the THAP1 gene on chromosome 8p21-p22 (DYT6 locus) have been recently reported as causative of autosomal dominant primary torsion dystonia (PTD) in four Amish-Mennonite families and in 12 additional probands of different ancestry. We sequenced the THAP1 gene in 158 patients with DYT1-negative PTD who had onset of symptoms below 30 years and/or positive family history. One sporadic Greek male patient, aged 57 years, was found to carry a novel heterozygous missense variant in THAP1 exon 3 (p.Cys170Arg), of likely pathogenic significance. This subject first presented with right writer's cramp at age of 10 years a...
Source: Movement Disorders - November 11, 2009 Category: Neurology Authors: Monica Bonetti, Chiara Barzaghi, Francesco Brancati, Alessandro Ferraris, Emanuele Bellacchio, Alessandro Giovanetti, Tamara Ialongo, Giovanna Zorzi, Carla Piano, Martina Petracca, Alberto Albanese, Nardo Nardocci, Bruno Dallapiccola, Anna Rita Bentivogli Source Type: journals

Dopamine dysregulation syndrome in a patient with early onset Parkinsonism and Parkin gene mutationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Movement Disorders)
Source: Movement Disorders - November 5, 2009 Category: Neurology Authors: Esther M. Sammler, Robert J. Swingler, Arlene Stuart, Miratul Muqit Source Type: journals

Dopamine agonist-induced antecollis in Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Few cases of dopamine agonist-induced antecollis in Parkinson's disease (PD) have been reported. Literature review of 16 PD patients including our 3 cases with dopamine agonist-induced antecollis showed predominance of (1) Japanese, (2) women, and (3) Hoehn-Yahr stage of [ge]3. We experienced three Japanese PD patients who subacutely exhibited antecollis following increased dopamine agonist dose that improved just after withdrawal of the agonist. One patient developed antecollis during increasing pramipexole dose in combination with cabergoline. Antecollis in another patient appeared during increasing pramipexole dose; it ...
Source: Movement Disorders - November 4, 2009 Category: Neurology Authors: Akiyuki Uzawa, Masahiro Mori, Shigeyuki Kojima, Satsuki Mitsuma, Yukari Sekiguchi, Toshihide Kanesaka, Satoshi Kuwabara Source Type: journals

Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a study of SNCA genetic variation in 452 idiopathic PD cases and 245 controls. SNCA copy number mutations were not associated with early-onset disease in this population. The minor allele "G" at rs356165 was associated with increased odds of PD (P = 0.013) and genetic variation in D4S3481 (Rep1) was associated with age of disease onset (P = 0.007). There was a trend toward association between variation at rs2583988 and rapid PD progression. © 2009 Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 4, 2009 Category: Neurology Authors: Alex Rajput, Carles Vilariño-Güell, Michele L. Rajput, Owen A. Ross, Alexandra I. Soto-Ortolaza, Sarah J. Lincoln, Stephanie A. Cobb, Michael G. Heckman, Matthew J. Farrer, Ali Rajput Source Type: journals

Longitudinal study of the levodopa motor response in Parkinson's disease: Relationship between cognitive decline and motor functionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this prospective study of 34 patients with Parkinson's disease (PD), measurements of the short duration levodopa motor response have been performed every 3 years in defined off states. The mean time from initiation of levodopa treatment was 14.8 years, and 17 patients survived to the latest assessment stage. Off phase motor function worsened at a yearly rate of 2.2% of the maximum disability score. The magnitude of the levodopa response is well preserved as the disease progresses, and patients who developed motor fluctuations maintained better on phase motor function than nonfluctuators (P = 0.01). Ten patients, of whom...
Source: Movement Disorders - November 4, 2009 Category: Neurology Authors: Jane E. Alty, Benjamin G. Clissold, Craig D. McColl, Katrina A. Reardon, Mark Shiff, Peter A. Kempster Source Type: journals

Olfactory dysfunction in Parkinsonism caused by PINK1 mutationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hyposmia is a common nonmotor feature of Parkinson's disease (PD) and has been variably detected in monogenic Parkinsonisms. To assess olfactory dysfunction in PINK1-related Parkinsonism, we evaluated olfactory detection threshold, odor discrimination, and odor identification in five groups of subjects: sporadic PD (n = 19), PINK1 homozygous (n = 7), and heterozygous (n = 6) parkinsonian patients, asymptomatic PINK1 heterozygous carriers (n = 12), and Italian healthy subjects (n = 67). All affected subjects and all healthy heterozygotes but one resulted hyposmic, with most patients in the range of functional anosmia or sev...
Source: Movement Disorders - November 4, 2009 Category: Neurology Authors: Alessandro Ferraris, Tamara Ialongo, Giulio Cesare Passali, Maria Teresa Pellecchia, Livia Brusa, Marianna Laruffa, Arianna Guidubaldi, Gaetano Paludetti, Alberto Albanese, Paolo Barone, Bruno Dallapiccola, Enza Maria Valente, Anna Rita Bentivoglio Source Type: journals

Validity of a self-rated method to identify a lifetime history of depression in Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Movement Disorders)
Source: Movement Disorders - November 4, 2009 Category: Neurology Authors: Nadeeka N. W. Dissanayaka, Annabelle N. Sellebach, Sally Matheson, Rodney Marsh, John D. O'Sullivan, Peter A. Silburn, Gerard J. Byrne, George D. Mellick Source Type: journals

Accuracy of Parkinson's disease diagnosis in 610 general practice patients in the West of ScotlandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
UK-based community studies have found high rates of misdiagnosis in Parkinson's disease (PD). Searches of prescription databases and case records identified 610 patients taking antiparkinson therapy for a PD diagnosis in 92 West of Scotland General Practices. Patients with no documented progression of parkinsonism and/or no increase in antiparkinson medication for 3 years were assessed by two movement disorder specialists. FP-CIT SPECT scanning was performed in clinically uncertain cases. Those considered unlikely to have PD had antiparkinson drugs tapered then stopped, with a minimum of 6 months follow-up. Age, sex and di...
Source: Movement Disorders - November 4, 2009 Category: Neurology Authors: Edward J. Newman, Kieran Breen, Jim Patterson, Donald M. Hadley, Katherine A. Grosset, Donald G. Grosset Source Type: journals

Do autonomic function tests in people with Parkinson's disease predict survival rates at 7 years follow-up?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Movement Disorders)
Source: Movement Disorders - November 4, 2009 Category: Neurology Authors: William K. Gray, Brian H. Wood, Richard W. Walker Source Type: journals

A family with a hereditary form of torsion dystonia from Northern Sweden treated with bilateral pallidal deep brain stimulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the results of pallidal DBS in a family with non-DYT1 dystonia where DYT5 to 17 was excluded. The dystonia is following an autosomal dominant pattern. Ten members had definite dystonia and five had dystonia with minor symptoms. Four patients received bilateral pallidal DBS. Mean age was 47 years. The patients were evaluated before surgery, and "on" stimulation after a mean of 2.5 years (range 1-3) using the Burke-Fahn-Marsden scale (BFM). Mean BFM score decreased by 79 % on stimulation, from 42.5 ± 24 to 9 ± 6.5 at the last evaluation. Cervical involvement improved by 89%. The 2 patients with oromandibular dys...
Source: Movement Disorders - November 4, 2009 Category: Neurology Authors: Patric Blomstedt, Marwan I. Hariz, Stephen Tisch, Monica Holmberg, Tommy A. Bergenheim, Lars Forsgren Source Type: journals

Remission of acute psychotic anxious depression in a patient with Parkinson's disease after treatment with quetiapineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Movement Disorders)
Source: Movement Disorders - November 4, 2009 Category: Neurology Authors: Silva Link, Walter Paulus, Borwin Bandelow Source Type: journals

No brain structure abnormalities in boys with Tourette's syndrome: A voxel-based morphometry studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Morphometric findings in Tourette's syndrome (TS) are still inconsistent probably due to differences in analysis approaches as well as several confounders (coexisting psychiatric conditions, medication status, etc.). Our aim was to identify possible morphometric changes in a well-defined sample of drug-naïve boys with "pure" TS. High-resolution structural magnetic resonance images of 38 boys with TS were compared with those of 38 healthy boys matched for age and IQ using voxel-based morphometry (VBM). Coexisting psychiatric conditions and previous medication were excluded. The inclusion of 10- to 15-year-old boys minimize...
Source: Movement Disorders - November 4, 2009 Category: Neurology Authors: Veit Roessner, Sebastian Overlack, Juergen Baudewig, Peter Dechent, Aribert Rothenberger, Gunther Helms Source Type: journals

Pramipexole and gender identity disorder: Expanding the phenotype of hypersexuality in Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Movement Disorders)
Source: Movement Disorders - November 4, 2009 Category: Neurology Authors: Mahesh Odiyoor, Christopher Kobylecki, Richard J. Hackett, Monty A. Silverdale, Mark W. Kellett Source Type: journals

Periodic leg movements and REM sleep without atonia in Parkinson's disease with camptocormiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Camptocormia (a flexion of the trunk that only appears when standing or walking) affects a minority of patients with Parkinson's disease (PD). As it responds poorly to levodopa and is associated with reduced midbrain and pons volume, it may result from non-dopaminergic, brainstem lesions. As several sleep abnormalities in PD also result from non-dopaminergic brainstem lesions, we monitored sleep in 24 non-demented PD patients with (n = 12) and without (n = 12) camptocormia and in 12 controls. Nearly half (42%) patients with camptocormia had abnormal periodic leg movement indices (>15/h), versus 17% patients without camptoc...
Source: Movement Disorders - November 4, 2009 Category: Neurology Authors: Sophie Lavault, Frederic Bloch, Jean-Luc Houeto, Eric Konofal, Marie-Laure Welter, Yves Agid, Isabelle Arnulf Source Type: journals

Opsoclonus myoclonus syndrome in the context of SalmonellosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Movement Disorders)
Source: Movement Disorders - October 20, 2009 Category: Neurology Authors: Olivier Flabeau, Wassilios Meissner, Alexandra Foubert-Samier, Dominique Guehl, Patrice Desbordes, François Tison Source Type: journals

Gene expression changes in blood as a putative biomarker for Huntington's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several studies demonstrated alterations of gene expression in blood in various neurological disorders including Huntington's disease (HD). Using microarray technology, a recent study identified a large number of significantly altered mRNAs in HD blood, from which a 12-gene set was selected as classifier for discriminating controls and HD patients. The aim of our study was to validate expression changes of these 12 genes in an independent cohort of HD patients and evaluate their sensitivity and specificity. Four different subject groups were included - patients with HD, Parkinson's disease (PD), acute ischemic stroke (AS) ...
Source: Movement Disorders - October 19, 2009 Category: Neurology Authors: Luca Lovrecic, Andrej Kastrin, Jan Kobal, Zvezdan Pirtosek, Dimitri Krainc, Borut Peterlin Source Type: journals

Plasma phenylalanine level in dopa-responsive dystoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Movement Disorders)
Source: Movement Disorders - October 19, 2009 Category: Neurology Authors: Hiroki Fujioka, Haruo Shintaku, Satoshi Kudo, Tsunekazu Yamano, Hiroki Fujioka Source Type: journals

A pilot study using nabilone for symptomatic treatment in Huntington's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pilot study of nabilone in Huntington's disease (HD). Double-blind, placebo-controlled, cross-over study of nabilone versus placebo. Primary outcome, Unified Huntington's Disease Rating Scale (UHDRS) total motor score. Secondary measures: UHDRS subsections for chorea, cognition and behavior, and neuropsychiatric inventory (NPI). 44 randomized patients received either nabilone (1 or 2 mg) followed by placebo (n = 22), or placebo followed by nabilone (n = 22). Recruiting was straightforward. Nabilone safe and well tolerated, no psychotic episodes. Assessment of either dose of nabilone versus placebo showed a treatment differ...
Source: Movement Disorders - October 19, 2009 Category: Neurology Authors: Adrienne Curtis, Ian Mitchell, Smitaa Patel, Natalie Ives, Hugh Rickards Source Type: journals

Eating dystoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Movement Disorders)
Source: Movement Disorders - October 19, 2009 Category: Neurology Authors: Yasar Kutukçu, Semai Bek, Tayfun Kasikçi, Gençer Genç, Zeki Odabasi Source Type: journals

Nigrostriatal dysfunction in homozygous and heterozygous parkin gene carriers: An 18F-dopa PET progression studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Little is known about the rate of progression of striatal dysfunction in subjects with parkin-linked parkinsonism. Being a heterozygous parkin gene carrier may confer susceptibility to Parkinson's disease (PD). In a previous 18F-dopa PET study, we reported that 69% of carriers of a single parkin mutation showed subclinical loss of putamen dopaminergic function. Using serial 18F-dopa PET, the present longitudinal study addresses rates of progression of nigrostriatal dysfunction in both compound heterozygous (parkin-linked parkinsonism) and single heterozygous parkin gene carriers. Three symptomatic patients who were compoun...
Source: Movement Disorders - October 19, 2009 Category: Neurology Authors: Nicola Pavese, Naheed L. Khan, Christoph Scherfler, Lisa Cohen, David J. Brooks, Nicholas W. Wood, Kailash P. Bhatia, Niall P. Quinn, Andrew J. Lees, Paola Piccini Source Type: journals

Giant somatosensory evoked potential in a patient with shaking TIAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Movement Disorders)
Source: Movement Disorders - October 19, 2009 Category: Neurology Authors: Myung Sik Lee, Won Joo Kim, Chul Hyoung Lyoo, Seon Jeong Kim, Gyoungim Suh Source Type: journals

Neurological symptoms in patients with biopsy proven celiac diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In celiac disease (CD), the gut is the typical manifestation site but atypical neurological presentations are thought to occur in 6 to 10% with cerebellar ataxia being the most frequent symptom. Most studies in this field are focused on patients under primary neurological care. To exclude such an observation bias, patients with biopsy proven celiac disease were screened for neurological disease. A total of 72 patients with biopsy proven celiac disease (CD) (mean age 51 ± 15 years, mean disease duration 8 ± 11 years) were recruited through advertisements. All participants adhered to a gluten-free diet. Patients were inter...
Source: Movement Disorders - October 19, 2009 Category: Neurology Authors: Katrin Bürk, Marie-Louise Farecki, Georg Lamprecht, Guenter Roth, Patrice Decker, Michael Weller, Hans-Georg Rammensee, Wolfang Oertel Source Type: journals

Unilateral periodic limb movements: Is this a pointer for atypical presentation of corticobasal degeneration syndrome? - A case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Movement Disorders)
Source: Movement Disorders - October 19, 2009 Category: Neurology Authors: Lorenzo Kiferle, Gloria Tognoni, Michelangelo Maestri, Carlo Rossi, Elisa Unti, Elisa Di Coscio, Enrica Bonanni, Roberto Ceravolo Source Type: journals

Paraneoplastic chorea associated with breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Movement Disorders)
Source: Movement Disorders - October 19, 2009 Category: Neurology Authors: Jana Martinková, Peter Valkovi[ccaron], Ján Benetin Source Type: journals

A validation exercise on the new consensus criteria for multiple system atrophyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The revised (new) consensus clinical diagnostic criteria for multiple system atrophy (MSA) were published in 2008. To validate these criteria, we utilized the same cohort that we reported previously, which included 59 patients with a clinical diagnosis of MSA that was confirmed neuropathologically in 51 of them at the Queen Square Brain Bank for Neurological Disorders. At the first clinic visit, sensitivity with new consensus possible category was higher, and PPV marginally higher, than for clinical diagnosis and old consensus possible category. New consensus probable category showed marginally higher sensitivity than, and...
Source: Movement Disorders - October 19, 2009 Category: Neurology Authors: Yasushi Osaki, Yoav Ben-Shlomo, Andrew J. Lees, Gregor K. Wenning, Niall P. Quinn Source Type: journals

Neck movement speed in cervical dystoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical scales of patients with cervical dystonia do not rate neck movement velocity. We prospectively measured range of neck movements and movement velocities in 35 consecutive patients with cervical dystonia (CD) and 29 normal controls. Reduction of peak velocities in patients with CD was the most robust abnormality and was correlated to TWSTRS. Coupled movements out of attempted movement plane were increased in the patient group. Movement range was moderately though significantly reduced. We conclude that slowing of voluntary neck movements is a frequent and hitherto unrecognized feature in CD. © 2009 Movement Disorde...
Source: Movement Disorders - October 19, 2009 Category: Neurology Authors: Diederik Zegers De Beyl, Patrick Salvia Source Type: journals

Complex movement disorders in a sporadic Boucher-Neuhäuser Syndrome: Phenotypic manifestations beyond the triadEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Movement Disorders)
Source: Movement Disorders - October 19, 2009 Category: Neurology Authors: Helen Ling, Kanjana Unnwongse, Roongroj Bhidayasiri Source Type: journals

Paramedical treatment in primary dystonia: A systematic reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dystonia is a disabling movement disorder with a significant impact on quality of life. The current therapeutic armamentarium includes various drugs, botulinum toxin injections, and occasionally (neuro)surgery. In addition, many patients are referred for paramedical (including allied health care) interventions. An enormous variation in the paramedical treatment is provided, largely because evidence-based, accepted treatment regimes are not available. We have conducted a systematic review of studies that explored the effect of various paramedical interventions in primary dystonia. Only studies that have used clinical outcom...
Source: Movement Disorders - October 15, 2009 Category: Neurology Authors: Cathérine C.S. Delnooz, Martin W.I.M. Horstink, Marina A. Tijssen, Bart P.C. van de Warrenburg Source Type: journals

Reversible encephalopathy and axonal neuropathy in Parkinson's disease during duodopa therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Movement Disorders)
Source: Movement Disorders - September 30, 2009 Category: Neurology Authors: Davide Manca, Giovanni Cossu, Daniela Murgia, Andrea Molari, Paola Ferrigno, Emanuele Marcia, Maurizio Melis Source Type: journals

Botulinum toxin in the treatment of lingual movement disordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lingual movement disorders are a rare but serious manifestation of neurologic disease, which have the potential to cause significant morbidity. Traditionally, these disorders were treated with pharmacotherapy achieving only limited results. Several case series have demonstrated the effectiveness of Botulinum toxin injection for the management of focal lingual movement disorders; however, apprehension persists regarding intralingual injections due to the risk of dysphagia. Here, we report seven patients with lingual movement disorders treated with intralingual BotoxTM (Allergan product) injections via a novel superior appro...
Source: Movement Disorders - September 29, 2009 Category: Neurology Authors: Neema Kasravi, Mandar S. Jog Source Type: journals

Cerebrospinal tau, phospho-tau, and beta-amyloid and neuropsychological functions in Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Alzheimer's disease (AD)-pathology may play a role in Parkinson's disease (PD)-related dementia (PDD). The aim of this study was to assess cerebrospinal fluid (CSF) levels of tau, phospho-tau, and beta-amyloid, proposed AD biomarkers, and their relationship with cognitive function in PD. Forty PD patients [20 nondemented (PDND); 20 PDD] and 30 controls underwent CSF tau, phospho-tau, and beta-amyloid analysis using specific ELISA techniques. All PD patients and 15 controls underwent neuropsychological testing of fronto-subcortical (attention, fluency) and neocortical (memory, naming, visuoperceptive) functions. CSF markers...
Source: Movement Disorders - September 29, 2009 Category: Neurology Authors: Yaroslau Compta, María J. Martí, Naroa Ibarretxe-Bilbao, Carme Junqué, Francesc Valldeoriola, Esteban Muñoz, Mario Ezquerra, Jose Ríos, Eduardo Tolosa Source Type: journals

Mirror movements in patients with essential tremorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this work is to study the prevalence and clinical correlates of MM in ET cases and controls. In a clinical-epidemiological study in New York, participants performed repetitive motor tasks; MM (hands and feet) were rated. MM occurred in 35/107 (32.7%) ET cases versus 23/97 (23.7%) controls (OR 1.56, P = 0.16). Total MM score was 2× higher in cases (3.9 ± 7.7 vs. 1.9 ± 3.9, P = 0.02). MM (hands) occurred in 16 (15.0%) cases versus 5 (5.2%) controls (OR 3.24, P = 0.03) and total hand MM score was three to four times higher in ET cases (1.4 ± 4.5 vs. 0.4 ± 2.0, P = 0.03). MMs were not correlated with age,...
Source: Movement Disorders - September 29, 2009 Category: Neurology Authors: Elan D. Louis, Eileen Rios, Claire Henchcliffe Source Type: journals

Combined use of DAT-SPECT and cardiac MIBG scintigraphy in mixed tremorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The cooccurrence of rest and postural tremor (mixed tremor) as the predominant clinical manifestation in patients who do not fulfill diagnostic established criteria for essential tremor (ET) or Parkinson's disease (PD) poses a clinical diagnostic challenge. Twenty-two patients with mixed tremor and additional mild extrapyramidal features, such as bradykinesia and rigidity, 20 patients with probable PD, 10 patients with probable ET, and 18 controls were investigated through the combined use of dopamine transporter 123I-FP-CIT-single-photon emission tomography (DAT-SPECT) and cardiac 123metaiodobenzylguanidine (MIGB) scintig...
Source: Movement Disorders - September 29, 2009 Category: Neurology Authors: Fabiana Novellino, Gennarina Arabia, Antonio Bagnato, Giuseppe Lucio Cascini, Maria Salsone, Giuseppe Nicoletti, Demetrio Messina, Maurizio Morelli, Sandra Paglionico, Laura Giofrè, Antonino Restuccia, Giusi Torchia, Francesca Condino, Aldo Quattrone Source Type: journals

Positive family history of essential tremor influences the motor phenotype of Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Previous reports have suggested that essential tremor (ET) represents a risk factor for the development of Parkinson's disease (PD). Patients with long-standing ET who develop PD tend to have a tremor-dominant subtype. To further clarify this association, we examined patients from kindreds with autosomal dominant ET who had signs of isolated PD but did not meet criteria for overlapping ET. We identified 22 patients with PD meeting these diagnostic criteria, and 90% (20 of 22) had tremor-predominant subtype of PD. Unilateral rest tremor was the presenting symptom in 15 of 22 patients, bradykinesia or rigidity in 5 of 22, an...
Source: Movement Disorders - September 29, 2009 Category: Neurology Authors: Peter Hedera, John Y. Fang, Fenna Phibbs, Michael K. Cooper, P. David Charles, Thomas L. Davis Source Type: journals