Response to: Tocilizumab, neuromyelitis optica (NMO), and multiple sclerosis
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Authors: Beauchemin, P., Carruthers, R. Tags: Letters Source Type: research
Tocilizumab, MS, and NMOSD
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Authors: Kleiter, I., Ayzenberg, I., Araki, M., Yamamura, T., Gold, R. Tags: Letters Source Type: research
Development of a primary cutaneous CD30(+) anaplastic large-cell T-cell lymphoma during treatment of multiple sclerosis with fingolimod
Conclusion:
Causality of fingolimod is indicated by the fact that the skin lesions appeared after commencement of treatment and resolved after discontinuation of therapy. This case serves as a reminder of the potential side effects of fingolimod. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Authors: Papathemeli, D., Gräfe, R., Hildebrandt, U., Zettl, U. K., Ulrich, J. Tags: Case Report Source Type: research
Plasma levels of endothelial and B-cell-derived microparticles are restored by fingolimod treatment in multiple sclerosis patients
Conclusion:
Fingolimod restored dysregulated endothelial and B-cell-microparticle numbers, which could serve as a biomarker in MS. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Authors: Zinger, A., Latham, S. L., Combes, V., Byrne, S., Barnett, M. H., Hawke, S., Grau, G. E. Tags: Short Report Source Type: research
Benchmarks of meaningful impairment on the MSFC and BICAMS
Conclusion:
We have established benchmark scores for popular motor and cognitive tests that are associated with specific degrees of impairment in work status. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Authors: Benedict, R. H., Drake, A. S., Irwin, L. N., Frndak, S. E., Kunker, K. A., Khan, A. L., Kordovski, V. M., Motl, R. W., Weinstock-Guttman, B. Tags: Original Research Papers Source Type: research
Evaluation of the Multiple Sclerosis Walking Scale-12 (MSWS-12) in a Dutch sample: Application of item response theory
Conclusion:
Our results confirm the good quality of the MSWS-12. The trait level () scores and item parameters of both the 12- and 11-item versions were highly comparable, although we do not suggest to change the content of the MSWS-12. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Authors: Mokkink, L. B., Galindo-Garre, F., Uitdehaag, B. M. Tags: Original Research Papers Source Type: research
Sick leave and disability pension before and after diagnosis of multiple sclerosis
Conclusion:
Patients with MS in Sweden have elevated levels of sick leave and disability pension up to 15 years before disease diagnosis. Our results highlight the burden of disease on affected patients and society and underscore the substantial unmet medical need. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Authors: Landfeldt, E., Castelo-Branco, A., Svedbom, A., Löfroth, E., Kavaliunas, A., Hillert, J. Tags: Original Research Papers Source Type: research
Cognitive impairment differs between neuromyelitis optica spectrum disorder and multiple sclerosis
Conclusion:
CI in patients with NMOSD may be not as common as in patients with MS. MS patients exhibited severe impairment, particularly on learning and memory tests, compared with NMOSD patients. Differential prevalence and patterns of CI between NMOSD and MS patients suggest that the two diseases have different mechanisms of brain injury. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Authors: Kim, S.-H., Kwak, K., Jeong, I. H., Hyun, J.-W., Jo, H.-J., Joung, A., Yu, E.-S., Kim, J.-H., Lee, S. H., Yun, S., Joo, J., Lee, D.-k., Lee, J.-M., Kim, H. J. Tags: Original Research Papers Source Type: research
Fatigue predicts disease worsening in relapsing-remitting multiple sclerosis patients
Conclusion:
Fatigue is a promising indicator of risk for conversion to confirmed moderate–severe disability in RRMS patients. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Authors: Cavallari, M., Palotai, M., Glanz, B. I., Egorova, S., Prieto, J. C., Healy, B. C., Chitnis, T., Guttmann, C. R. Tags: Original Research Papers Source Type: research
Peripartum depression in parents with multiple sclerosis and psychiatric disorders in children
Conclusion:
Parental MS is associated with a higher risk of peripartum depression and increases the risk of psychiatric disorders in children. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Authors: Razaz, N., Tremlett, H., Marrie, R. A., Joseph, K. S. Tags: Original Research Papers Source Type: research
Children with multiphasic disseminated encephalomyelitis and antibodies to the myelin oligodendrocyte glycoprotein (MOG): Extending the spectrum of MOG antibody positive diseases
Conclusion:
Children with MDEM and persisting MOG antibodies constitute a distinct entity of relapsing demyelinating events and extend the spectrum of MOG antibody–associated diseases. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Authors: Baumann, M., Hennes, E.-M., Schanda, K., Karenfort, M., Kornek, B., Seidl, R., Diepold, K., Lauffer, H., Marquardt, I., Strautmanis, J., Syrbe, S., Vieker, S., Höftberger, R., Reindl, M., Rostasy, K. Tags: Original Research Papers Source Type: research
Impaired retinal microcirculation in multiple sclerosis
Conclusion:
The impaired retinal microcirculation in RRMS patients indicates microvascular dysfunction in MS. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Authors: Jiang, H., Delgado, S., Tan, J., Liu, C., Rammohan, K. W., DeBuc, D. C., Lam, B. L., Feuer, W. J., Wang, J. Tags: Original Research Papers Source Type: research
The substrate of increased cortical FA in MS: A 7T post-mortem MRI and histopathology study
Conclusion:
FA increase was not due to lesional and non-lesional differences in microglia activation and/or proliferation. We found an increase in general cellular density without a notable difference in cellular size, that is, tissue compaction, as a possible alternative explanation. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Authors: Jonkman, L. E., Klaver, R., Fleysher, L., Inglese, M., Geurts, J. J. Tags: Original Research Papers Source Type: research
Abnormal galactosylation of immunoglobulin G in cerebrospinal fluid of multiple sclerosis patients
Background:
Glycosylation alterations have been associated with the development of several human diseases and their animal models, including multiple sclerosis.
Objectives:
We aimed to determine whether immunoglobulin G galactosylation might be changed in multiple sclerosis.
Methods:
Immunoglobulin G was isolated from serum and cerebrospinal fluid of patients with multiple sclerosis or viral meningitis and control patients without history of inflammatory or autoimmune disease. A lectin-based assay was used to investigate potential galactosylation modifications of immunoglobulin G.
Results and conclusion:
Galactosylation...
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Authors: Decker, Y., Schomburg, R., Nemeth, E., Vitkin, A., Fousse, M., Liu, Y., Fassbender, K. Tags: Original Research Papers Source Type: research
Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors
Background:
Epidemiological findings suggest a relationship between multiple sclerosis (MS) and cardiovascular disease (CVD) risk factors, although the nature of this relationship is not well understood.
Objective:
We used genome-wide association study (GWAS) data to identify shared genetic factors (pleiotropy) between MS and CVD risk factors.
Methods:
Using summary statistics from a large, recent GWAS (total n > 250,000 individuals), we investigated overlap in single nucleotide polymorphisms (SNPs) associated with MS and a number of CVD risk factors including triglycerides (TG), low-density lipoprotein (LDL) choleste...
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Authors: Wang, Y., Bos, S. D., Harbo, H. F., Thompson, W. K., Schork, A. J., Bettella, F., Witoelar, A., Lie, B. A., Li, W., McEvoy, L. K., Djurovic, S., Desikan, R. S., Dale, A. M., Andreassen, O. A. Tags: Original Research Papers Source Type: research
