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2009 ACTRIMS ABSTRACTS: Poster PresentationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Tags: Articles Source Type: journals

2009 ACTRIMS ABSTRACTS: Oral PresentationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Tags: Articles Source Type: journals

Severe liver dysfunction in a patient with multiple sclerosis: the guilty party is not always the disease-modifying therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Hotermans, C., Belachew, S., Moonen, G., Delwaide, J. Tags: Articles Source Type: journals

Multiple sclerosis patients with bladder dysfunction have decreased symptoms after electro-acupunctureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Tjon Eng Soe, S., Kopsky, D., Jongen, P., de Vet, H., Oei-Tan, C. Tags: Articles Source Type: journals

Matrix metalloproteinase-9 and matrix metalloproteinase-2 as biomarkers of various courses in multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Benesova, Y. Tags: Articles Source Type: journals

Consideration of preanalytical impact of blood sampling on measurement of matrix metalloproteinases and their inhibitors as precondition to evaluate their relationship to clinical dataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Jung, K. Tags: Articles Source Type: journals

Celiac disease, Behcet, and idiopathic thrombocytopenic purpura in siblings of a patient with multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a 30-year-old woman with MS, the product of consanguineous marriage, and three siblings with three different autoimmune diseases: idiopathic thrombocytopenic purpura, celiac disease, and Behçet’s disease. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Yamout, B., Usta, J., Itani, S., Yaghi, S. Tags: Articles Source Type: journals

Cigarette smoking and risk of MS in multiplex familiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent studies suggest that a history of cigarette smoking is a risk factor for multiple sclerosis (MS). We aimed to test the smoking effect in multiplex families, matching for both environmental and genetic factors. In a matched case-control study, 136 MS patients from 106 multiplex MS families were compared with their 204 healthy siblings as controls. Participants completed self-report questionnaires. Conditional logistic regression was used to analyse smoking and MS risk association while controlling for confounding by age and sex. Smoking history was classified in different variables. Within our survey the smoking hist...
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Jafari, N., Hoppenbrouwers, I. A, Hop, W. C., Breteler, M. M., Hintzen, R. Q Tags: Articles Source Type: journals

Severe relapses after the first infusion of natalizumab in active relapsing--remitting multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe three patients suffering from a very active form of relapsing—remitting multiple sclerosis (MS), who experienced severe disease worsening, associated with a marked increase in brain inflammation, a few days after the first administration of natalizumab. In line with preclinical studies, our observations suggest that natalizumab, when administered during active disease phases, may worsen disease evolution possibly by modifying the regulatory network in the brain. We suggest that relapsing—remitting MS patients having had a recent relapse should be treated with natalizumab only after achieving complet...
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Rinaldi, F., Perini, P., Calabrese, M., Rinaldi, L., Gallo, P. Tags: Articles Source Type: journals

First trimester interleukin 8 levels are associated with postpartum relapse in multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pregnancy has an ameliorating effect on multiple sclerosis (MS), but directly after delivery the risk of a relapse is increased. The pro-inflammatory chemokine interleukin 8 is associated with disease activity. We aimed to investigate whether pregnancy-induced fluctuations of interleukin 8 correlate with periods of enhanced and diminished disease activity. Thirty-six women with MS were prospectively studied before, during and after pregnancy. Serum levels of interleukin 8 were significantly decreased during the third trimester (p = 0.03). High first trimester serum levels of interleukin 8 were associated with a high risk o...
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Neuteboom, R. F, Verbraak, E., Voerman, J. S., van Meurs, M., Steegers, E. A., de Groot, C. J., Laman, J. D, Hintzen, R. Q Tags: Articles Source Type: journals

Burden and health-related quality of life of Spanish caregivers of persons with multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Little information exists about caregivers of persons with multiple sclerosis (MS). Our aims were to describe the characteristics of a sample of caregivers of persons with MS, assess their perceived burden, health-related quality of life, and investigate factors influencing this burden. We studied 278 caregivers of persons with MS, recruited from a Spanish cross-sectional survey, measuring health-related quality of life by the 36-Item Short-Form Health Survey (SF-36) and burden by the Zarit Caregiver Burden Interview. Of the caregivers, 56.8% were female and their mean age was 50.1 ± 12.6 years. Their main relations...
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Rivera-Navarro, J., Benito-Leon, J., Oreja-Guevara, C., Pardo, J., Bowakim Dib, W., Orts, E., Bello, M., Caregiver Quality of Life in Multiple Sclerosis (CAREQOL-MS) Study Group Tags: Articles Source Type: journals

Gender differences in health-related quality of life in multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Women have about twice the risk of developing multiple sclerosis (MS) compared with men, a ratio that seems to be increasing. Most studies show that female patients seem to have a more favourable outcome of the disease. We studied the gender-specific impact of MS on health-related quality of life. We surveyed the population prevalence of MS patients in Ferrara, Italy. Data were extracted from the MS registry of the study area. Health-related quality of life was assessed using the MSQOL54 questionnaire. We analysed 370 patients (105 men and 265 women). They had worse scores than the general population in all health-related ...
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Casetta, I., Riise, T., Wamme Nortvedt, M., Economou, N. T., De Gennaro, R., Fazio, P., Cesnik, E., Govoni, V., Granieri, E. Tags: Articles Source Type: journals

Reflexology for the treatment of pain in people with multiple sclerosis: a double-blind randomised sham-controlled clinical trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, precision reflexology was not superior to sham, however, both treatments offer clinically significant improvements for MS symptoms via a possible placebo effect or stimulation of reflex points in the feet using non-specific massage. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Hughes, C., Smyth, S., Lowe-Strong, A. Tags: Articles Source Type: journals

Hypothalamic stimulation for trigeminal neuralgia in multiple sclerosis patients: efficacy on the paroxysmal ophthalmic painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, deep brain stimulation may be considered as an adjunctive procedure for treating refractory paroxysmal pain within the first trigeminal division so as to avoid the complication of corneal reflex impairment that is known to follow ablative procedures. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Cordella, R., Franzini, A., La Mantia, L., Marras, C., Erbetta, A., Broggi, G. Tags: Articles Source Type: journals

Thalamic stimulation in multiple sclerosis: evidence for a 'demyelinative thalamotomy'Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The mechanism of action of deep brain stimulation (DBS) in the alleviation of tremor in multiple sclerosis (MS) and other neurological disorders is unknown. Moreover, whether the trauma accompanying this surgery is responsible for the induction of new MS plaques is controversial. Here we report the first description of the post-mortem imaging and pathologic findings in the brain of a MS patient who underwent thalamic DBS for the treatment of MS-induced tremor. MR imaging of formalin-fixed brain slices was carried out at 1.5, 3 and 7 Tesla and correlated with the histopathology. There were numerous demyelinative plaques in ...
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Moore, G. W., Vitali, A. M, Leung, E., Laule, C., Kozlowski, P., MacKay, A. L, Honey, C. R Tags: Articles Source Type: journals

Revision of the risk of secondary leukaemia after mitoxantrone in multiple sclerosis populations is requiredEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective in this paper is to compare the cumulative incidence and incidence density of therapy-related acute myeloid leukaemia in two cohorts of patients with multiple sclerosis treated with mitoxantrone, and with previously reported data in the literature. Six new cases of acute myeloid leukaemia were observed by prospectively following two Spanish series of 142 and 88 patients with worsening relapsing multiple sclerosis and secondary-progressive disease treated with mitoxantrone. A literature review shows 32 further cases of acute myeloid leukaemia reported, 65.6% of which are therapy-related acute promyelocytic leu...
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Pascual, A. M, Tellez, N., Bosca, I., Mallada, J., Belenguer, A., Abellan, I., Sempere, A. P, Fernandez, P., Magraner, M. J., Coret, F., Sanz, M. A, Montalban, X., Casanova, B. Tags: Articles Source Type: journals

Clinically isolated acute transverse myelitis: prognostic features and incidenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Demyelinating acute transverse myelitis may be the first presentation of multiple sclerosis or remain a clinically isolated syndrome. North Canterbury, New Zealand provides a well circumscribed population to study acute transverse myelitis. Objective: to identify prognostic features, clinical outcomes and incidence of ATM in North Canterbury, New Zealand. All patients with acute transverse myelitis as a first neurological presentation diagnosed from January 2001 to December 2005 at a single institution providing all neurological care for North Canterbury were assessed for clinical data, MRI findings, cerebrospinal fluid re...
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Young, J., Quinn, S., Hurrell, M., Taylor, B. Tags: Articles Source Type: journals

Disease progression among multiple sclerosis patients before and during a disease-modifying drug program: a longitudinal population-based evaluationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Randomized controlled trials have demonstrated the efficacy of disease-modifying drugs (DMDs) in persons with relapsing—remitting multiple sclerosis (MS) and secondary progressive MS with superimposed relapses. However, these brief studies of selected patients have focused mainly on reducing attacks and must be complemented by evaluations in ‘realworld’ clinical settings to establish the effectiveness of DMD programs in slowing disease progression and to inform health policy and program decision-making. We assessed the effectiveness of DMDs as administered in a comprehensive publicly funded drug insurance...
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Veugelers, P., Fisk, J., Brown, M., Stadnyk, K., Sketris, I., Murray, T., Bhan, V. Tags: Articles Source Type: journals

25-Hydroxyvitamin D in cerebrospinal fluid during relapse and remission of multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hypovitaminosis D may play a role in multiple sclerosis (MS), but little is known about intrathecal vitamin D. 25-Hydroxyvitamin D was measured in cerebrospinal fluid and sera from 36 patients with relapsing-remitting MS, 20 patients with other inflammatory neurological diseases and 18 patients with non-inflammatory neurological diseases with liquid chromatography-mass spectrometry. There were no significant differences in cerebrospinal fluid concentrations of 25-hydroxyvitamin D, but the cerebrospinal fluid:serum ratio was significantly lower in MS compared with other inflammatory neurological diseases (p=0.0012) and non-...
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Holmoy, T., Moen, S. M., Gundersen, T. A, Holick, M. F, Fainardi, E., Castellazzi, M., Casetta, I. Tags: Articles Source Type: journals

Serum levels of CXCL13 are elevated in active multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There is increasing recognition of the important role that B cells play in the pathogenesis of multiple sclerosis (MS). Recently it was reported that the B cell chemokine CXCL13 is elevated in MS serum and cerebrospinal fluid. Here we study whether serum levels of CXCL13 are associated with active MS. We measured serum levels of CXCL13 by enzyme-linked immunosorbent assay in 74 patients with relapsing MS randomized to interferon beta 1b or glatiramer acetate and examined with monthly 3 T brain MRI scans optimized for detection of gadolinium-enhancement for up to 2 years. The median (range) serum levels of CXCL13 pre-treatm...
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Festa, E. D, Hankiewicz, K., Kim, S., Skurnick, J., Wolansky, L. J, Cook, S. D, Cadavid, D. Tags: Articles Source Type: journals

Excess mortality and cause of death in a cohort of Norwegian multiple sclerosis patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There are few studies of long-term, cause-specific mortality in multiple sclerosis (MS) relating to population mortality. Our objective was to study survival, excess mortality and causes of death in a cohort of patients with a long history of MS. Patients living in Oslo with definite MS and onset during 1940—80 were included in 2006. Causes of death and mortality in the general population were obtained from the Cause of Death Registry of Statistics Norway. Of the 386 patients included in the study, 263 (68%) had died at inclusion. Median survival from onset was 35 years (Kaplan—Meier: 95% confidence interval 33...
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Smestad, C., Sandvik, L., Celius, E. Tags: Articles Source Type: journals

High prevalence of multiple sclerosis in the Swedish county of VarmlandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this study supports previous reports indicating that Värmland continues to be a high-risk zone for MS and shares in the diffusion of the disease at the county level which we had presented for the country as a whole. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Bostrom, I., Callander, M., Kurtzke, J. F, Landtblom, A.-M. Tags: Articles Source Type: journals

Evidence of treatment benefit: is seeing believing or obfuscation by statistics?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Cutter, G. Tags: Articles Source Type: journals

Early treatment of multiple sclerosis: a Latin American Experts MeetingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, patients with CIS are usually young, with often-limited symptomatic manifestations, and must be adequately prepared to receive preventive treatment. This consensus review should contribute to the dialogue between physicians and patients. Multiple Sclerosis 2009; 15: S1—S12. http://msj.sagepub.com (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 21, 2009 Category: Neurology Authors: Garcea, O., Villa, A., Caceres, F., Adoni, T., Alegria, M., Barbosa Thomaz, R., Buzo, R., Llamas Lopez, L., Rivera Kindel, M. Tags: Articles Source Type: journals

The functional index for living with multiple sclerosis: development and validation of a new quality of life questionnaireEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Addressing health-related quality of life is considered a desirable component of routine care for patients with multiple sclerosis. However, use of available health-related quality of life surveys is not part of routine multiple sclerosis care, possibly due to administration, scoring, and interpretation challenges presented by available questionnaires. The 25-item Functional Index for Living with Multiple Sclerosis (FILMS) questionnaire was developed and validated to allow providers to monitor and easily apply health-related quality of life information to the patient encounter. The development and pilot test processes and ...
Source: Multiple Sclerosis - October 16, 2009 Category: Neurology Authors: Wesson, J., Cooper, J., Jehle, L., Lockhart, S., Draney, K., Barber, J. Tags: Articles Source Type: journals

The development and validation of the Unidimensional Fatigue Impact Scale (U-FIS)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: It is valid to conceptualize the functional impact of fatigue as unidimensional. The U-FIS is a reliable and valid questionnaire that will allow the measurement of this construct in clinical studies. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 16, 2009 Category: Neurology Authors: Meads, D., Doward, L., McKenna, S., Fisk, J., Twiss, J., Eckert, B. Tags: Articles Source Type: journals

Walking and talking: an investigation of cognitive--motor dual tasking in multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Difficulty with walking and talking in MS may be a result of a divided attention deficit or of overloading of the working memory system, and further investigation is needed. We suggest that difficulty with walking and talking in MS may lead to practical problems in everyday life, including potentially increasing the risk of falls. Clinical tools to assess cognitive—motor dual-tasking ability are needed. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 16, 2009 Category: Neurology Authors: Hamilton, F., Rochester, L., Paul, L., Rafferty, D., O'Leary, C., Evans, J. Tags: Articles Source Type: journals

Treatment with the phosphodiesterase type-4 inhibitor rolipram fails to inhibit blood--brain barrier disruption in multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rolipram, a prototypic phosphodiesterase-4 inhibitor, is highly effective in suppressing Th1 autoimmunity in multiple animal models, including experimental autoimmune encephalomyelitis. In addition, rolipram has been extensively studied as a potential neuroprotective agent. Based on its anti-inflammatory activity, we tested the efficacy of rolipram in suppressing inflammatory disease activity in multiple sclerosis in a proof-of-principle phase I/II open-label clinical trial. Enrolled MS patients were evaluated by monthly MRI and clinical examinations during 3 months (four MRIs) of pretreatment baseline and 8 months of roli...
Source: Multiple Sclerosis - October 16, 2009 Category: Neurology Authors: Bielekova, B., Richert, N., Howard, T., Packer, A. N, Blevins, G., Ohayon, J., McFarland, H. F, Sturzebecher, C.-S., Martin, R. Tags: Articles Source Type: journals

A single-center, randomized, double-blind, placebo-controlled study of interferon beta-1b on primary progressive and transitional multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inflammation and neurodegeneration may have differential impacts on disease evolution in the different forms of multiple sclerosis. However, a beneficial effect of immunomodulatory drugs should not be ruled out in primary progressive multiple sclerosis. Our aim is to investigate the safety and efficacy of interferon beta-1b in primary progressive multiple sclerosis. We conducted a double-blind, stratified, randomized, parallel group, phase II pilot study where patients with primary progressive multiple sclerosis or ‘transitional’ forms of multiple sclerosis received interferon beta-1b at doses of 8 MIU or place...
Source: Multiple Sclerosis - October 16, 2009 Category: Neurology Authors: Montalban, X., Sastre-Garriga, J., Tintore, M., Brieva, L., Aymerich, F., Rio, J., Porcel, J., Borras, C., Nos, C., Rovira, A. Tags: Articles Source Type: journals

Glatiramer acetate in combination with minocycline in patients with relapsing--remitting multiple sclerosis: results of a Canadian, multicenter, double-blind, placebo-controlled trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Minocycline is proposed as an add-on therapy to improve the efficacy of glatiramer acetate in relapsing—remitting multiple sclerosis. The effect of minocycline plus glatiramer acetate was evaluated in this double-blind, placebo-controlled study by determining the total number of T1 gadolinium-enhanced lesions at months 8 and 9 in patients who were starting glatiramer acetate and had at least one T1 gadolinium-enhanced lesion on screening magnetic resonance imaging. Forty-four participants were randomized to either minocycline 100 mg twice daily or matching placebo for 9 months as add-on therapy. They were assessed at...
Source: Multiple Sclerosis - October 16, 2009 Category: Neurology Authors: Metz, L., Li, D., Traboulsee, A., Myles, M., Duquette, P., Godin, J., Constantin, M., Yong, V. Tags: Articles Source Type: journals

Review: Treatment of early multiple sclerosis: the value of treatment initiation after a first clinical episodeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Multiple sclerosis is a chronic, demyelinating disorder of the central nervous system. It is characterised by progressive neurological disability, which is likely to occur as a result of permanent axonal damage. Such damage may be reflected by brain atrophy, which can be identified early in the course of the disease. Patients who present with an initial episode of inflammatory demyelination, commonly referred to as a clinically isolated syndrome, are at high risk of developing clinically definite multiple sclerosis, especially if their magnetic resonance imaging studies suggest the presence of multi-focal disease. Treatmen...
Source: Multiple Sclerosis - October 16, 2009 Category: Neurology Authors: Goodin, D., Bates, D. Tags: Articles Source Type: journals

Cognitive decline in multiple sclerosis: impact of topographic lesion distribution on differential cognitive deficit patternsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Third ventricle width as a straight-forward measure of central atrophy proved to be of substantial predictive value for cognitive dysfunction, whereas total lesion load played only a minor role. Periventricular located lesions were significantly related to decreased psychomotor speed, whereas equally distributed cerebral lesion load did not. These findings support the idea that periventricular lesions have a determinant impact on cognition in patients with MS. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 16, 2009 Category: Neurology Authors: Tiemann, L., Penner, I., Haupts, M., Schlegel, U., Calabrese, P. Tags: Articles Source Type: journals

Antiacquaporin 4 antibodies detection by different techniques in neuromyelitis optica patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Detection of NMO-IgG or anti-AQP4 antibodies may represent a valuable tool to assist neurologists in the differential diagnosis between patients with NMO, hrNMO, APTM, or MS. The current lack of a gold standard to detect anti-AQP4 antibodies implies the necessity to standardize the detection of these antibodies. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 16, 2009 Category: Neurology Authors: Fazio, R., Malosio, M., Lampasona, V., De Feo, D., Privitera, D., Marnetto, F., Centonze, D., Ghezzi, A., Comi, G., Furlan, R., Martino, G. Tags: Articles Source Type: journals

Season of birth and not vitamin D receptor promoter polymorphisms is a risk factor for multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our data suggest that high levels of vitamin D during the third trimester of pregnancy could be a protective factor for multiple sclerosis. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 16, 2009 Category: Neurology Authors: de Abreu, D. F., Babron I, M., Rebeix, C., Fontenille, J., Yaouanq, D., Brassat, B., Fontaine, F., Clerget-Darpoux, F., Jehan, F., Feron, Tags: Articles Source Type: journals

Experimental autoimmune encephalomyelitis-induced upregulation of tumor necrosis factor-alpha in the dorsal root gangliaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Antigen-induced production of inflammatory cytokines such as TNF within the DRG identifies a potential novel mechanism for MS-induced NPP. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 16, 2009 Category: Neurology Authors: Melanson, M., Miao, P., Eisenstat, D., Gong, Y., Gu, X., Au, K., Zhu, W., Begum, F., Frost, E., Namaka, M. Tags: Articles Source Type: journals

'Time is brain' also in multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 16, 2009 Category: Neurology Authors: Freedman, M. S. Tags: Articles Source Type: journals

Parallel Session 13 -- Late Breaking NewsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - September 8, 2009 Category: Neurology Tags: Article Source Type: journals

Posters II: MS Variants - 2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - September 8, 2009 Category: Neurology Tags: Article Source Type: journals

Posters I: Diagnosis and differential diagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - September 8, 2009 Category: Neurology Tags: Article Source Type: journals

Abstracts: Oral PresentationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - September 8, 2009 Category: Neurology Tags: Article Source Type: journals

Dose-dependent melanonychia by mitoxantroneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an unusual case of a 43-year old female patient suffering from multiple sclerosis, who was treated with mitoxantrone. Few weeks after treatment initiation a hyperpigmentation of the patient’s left thumb and index was noted. Following dose-reduction (from 12 to 10 mg/m2) and over the further course of mitoxantrone treatment the discoloration slightly faded. Although mitoxantrone is known to cause hyperpigmentation of various tissues this is the first report of melanonychia without hyperpigmentation of other tissue. Albeit speculative, pathogenesis of selective melanonychia by mitoxantrone could involve ...
Source: Multiple Sclerosis - August 18, 2009 Category: Neurology Authors: Reinsberger, C, Meuth, S., Wiendl, H Tags: Article Source Type: journals

Multiple sclerosis and neurofibromatosis type 1: report of seven patients from IranEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ConclusionThe findings of this study suggest a possible casual relationship between MS and NF1, indicating higher risk of MS among patients with NF1. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - August 18, 2009 Category: Neurology Authors: Etemadifar, M, Fatehi, F, Sahraian, M., Borhanihaghighi, A, Ardestani, P., Kaji-Esfahani, M, Maghzi, A. Tags: Article Source Type: journals

Foreign accent syndrome as a first sign of multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ConclusionFAS may be the first symptom of MS. It could result from extensive disturbances of brain function involving the right hemisphere. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - August 18, 2009 Category: Neurology Authors: Chanson, J., Kremer, S, Blanc, F, Marescaux, C, Namer, I., de Seze, J Tags: Article Source Type: journals

Lower urinary tract dysfunction in acute disseminated encephalomyelitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ConclusionLUTD is common in ADEM, especially in patients with lower limb pyramidal involvement and its causes multifactorial. Presence of LUTD does not influence the functional outcome of patients with ADEM. Recovery may be incomplete and symptoms may persist even after recovery of other neurological deficits. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - August 18, 2009 Category: Neurology Authors: Panicker, J., Nagaraja, D, Kovoor, J., Nair, K., Subbakrishna, D. Tags: Article Source Type: journals

Extensive vasogenic edema of anti-aquaporin-4 antibody-related brain lesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ConclusionAnti-AQP4 antibody is considered to be associated with the neuroimaging appearances of vasogenic edema. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - August 18, 2009 Category: Neurology Authors: Matsushita, T, Isobe, N, Matsuoka, T, Ishizu, T, Kawano, Y, Yoshiura, T, Ohyagi, Y, Kira, J Tags: Article Source Type: journals

Suspected multiple sclerosis - what to do? Evaluation of a patient information leafletEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ConclusionTaken together, our findings demonstrate that early information about possible MS is warranted by patients and does not show negative side effects. Further studies on evidence-based patient information in early MS seem necessary. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - August 18, 2009 Category: Neurology Authors: Heesen, C, Schaffler, N, Kasper, J, Muhlhauser, I, Kopke, S Tags: Article Source Type: journals

The development of patient-reported outcome indices for multiple sclerosis (PRIMUS)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ConclusionsClinicians and researchers can have confidence in scores obtained by respondents on the PRIMUS. The PRIMUS will aid the assessment of the impact of MS from the patient’s perspective. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - August 18, 2009 Category: Neurology Authors: Doward, L., McKenna, S., Meads, D., Twiss, J, Eckert, B. Tags: Article Source Type: journals

Home administration of intravenous methylprednisolone for multiple sclerosis relapses: the experience of French multiple sclerosis networksEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ConclusionSafety data, patient satisfaction, and economic considerations support home-based treatment of MS relapses with intravenous methylprednisolone, provided strict patient selection criteria are observed and the process is coordinated and closely monitored by an MS network. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - August 18, 2009 Category: Neurology Authors: Creange, A, Debouverie, M, Jaillon-Riviere, V, Taithe, F, Liban, D, Moutereau, A, Clavelou, P, Defer, G Tags: Article Source Type: journals

Sensitivity of conventional memory tests in multiple sclerosis: comparing the Rao Brief Repeatable Neuropsychological Battery and the Minimal Assessment of Cognitive Function in MSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ConclusionsWe conclude that the BRNB and MACFIMS have comparable sensitivity among patients with MS. The sensitivity of the auditory/verbal memory tests from these batteries is similar, but the BVMTR appears to be more sensitive than the 10/36. Clinical implications are discussed. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - August 18, 2009 Category: Neurology Authors: Strober, L, Englert, J, Munschauer, F, Weinstock-Guttman, B, Rao, S, Benedict, R. Tags: Article Source Type: journals

Brain abnormalities in Sjogren syndrome with recurrent CNS manifestations: association with neuromyelitis opticaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ConclusionsThis study demonstrates that SS patients with recurrent CNS involvement have brain abnormalities characteristic of NMO and AQP4-Ab in Korea. The presence of AQP4-Ab in one SS patient with only brain involvement may suggest that the coexistence of NMO should be explored in SS patients with recurrent CNS manifestations, even without optic neuritis or myelitis. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - August 18, 2009 Category: Neurology Authors: Min, J., Kim, H., Kim, B., Lee, K., Sunwoo, I., Kim, S., Kim, B., Kim, S., Park, M., Waters, P, Vincent, A, Sung, J., Lee, K. Tags: Article Source Type: journals