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Predicting Side Effects and Repurposing DrugsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As a drug binds to a protein to lower cholesterol or inhibit the growth of breast cancer cells, it also brushes up against thousands of other molecules. These on- and off-target interactions determine a drug's beneficial effect as well as its side effects. Now, a team of pharmaceutical chemists has devised a method for predicting a drug's close contacts inside the body, providing a new way to identify unwanted interactions and novel therapeutic targets. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - November 16, 2009 Category: Biomedical Science Source Type: consumer

10 Reasons Biologists Should Know Some MathEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Drs. Jeremy Berg, Peter Lyster and Sarah Dunsmore talk about the role of math in studying biology. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - November 2, 2009 Category: Biomedical Science Source Type: consumer

Stretch Detectors: Modeling Contractile ForcesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers built a microscopic scaffold and developed a computer model to study how tissues stretch and contract in our bodies. Their findings—which show that contractile forces vary throughout a stretched tissue—could have a wide range of medical applications. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - October 15, 2009 Category: Biomedical Science Source Type: consumer

Modeling How Wounds HealEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers have built the first mathematical model of a type of chronic wound that can lead to amputation and even death. The new model will help researchers answer questions about wounds and how best to treat them. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - September 28, 2009 Category: Biomedical Science Source Type: consumer

Metabolic Network Takes ShapeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Like cartographers including mountain peaks or river channels to give dimension to a flat map, a research team has used computational modeling to add a third dimension--protein structures--to its map of a metabolic network. The new picture could lead to insights about basic biology and evolution. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - September 17, 2009 Category: Biomedical Science Source Type: consumer

Disease Modeling Efforts Gain New GroundEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Read about the new research groups that will help the nation—and the world—understand and prepare for contagious outbreaks. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - September 3, 2009 Category: Biomedical Science Source Type: consumer

Research on a Mission: Five Years with MIDASEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Why is it important to model the dynamics of infectious disease spread? What are the benefits and limitations of these models? How do computer modelers work together with public health officials? Director Irene Eckstrand answers these questions and more as the Models of Infectious Disease Agent Study, or MIDAS, celebrates its fifth anniversary. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - September 3, 2009 Category: Biomedical Science Source Type: consumer

First Look: Policy InformaticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the emerging field of policy informatics, computer scientists are giving public health planners the tools to model disease spread and control. By comparing possible intervention strategies in computer simulations, policymakers can arrive at better-informed decisions about how to combat the H1N1 outbreak. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - August 24, 2009 Category: Biomedical Science Source Type: consumer

What Is an Ontology?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Biomedical research has gotten messy. Scientists in different labs and disciplines use different terms for what they’re studying, and their results aren’t always consistently labeled. Other scientists trying to compare this information don’t necessarily know what they’re looking at. Computer programmers want to help clean up—and they're doing it by building virtual libraries called ontologies. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - August 10, 2009 Category: Biomedical Science Source Type: consumer

Of Cells and CircuitsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Where do biologists, physicists, chemists and computer scientists meet? Not just at interdepartmental parties, but in systems biology centers that are springing up across the country. Researchers combine experiments with computer simulation to better understand cell processes and organisms on a holistic level. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - July 28, 2009 Category: Biomedical Science Source Type: consumer

New Drugs: Getting More Out of NatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature is a prolific source of new medicines, but turning its products into drugs is labor-intensive and time-consuming. New computational tools could make it easier to study and rapidly determine whether natural compounds collected in oceans and forests are potential new candidates for drug development. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - July 16, 2009 Category: Biomedical Science Source Type: consumer

Disease-Spread Modeling Gets Help from FacebookEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The popular social networking site has given researchers a leg up on studying the spread of H1N1 and other potential infectious diseases. Researchers posted questions on Facebook and later developed a survey to capture people’s reactions to the actual outbreak. The results ultimately will help them model how changes in decision-making influence patterns of disease spread. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - June 11, 2009 Category: Biomedical Science Source Type: consumer

Comparing Genomes to Find What Makes Us HumanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As the recent flu outbreak continues to capture our attention, the seasonal flu season in the southern hemisphere is about to start. Read about a new technique for tracing the global spread of flu. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - May 21, 2009 Category: Biomedical Science Source Type: consumer

Following FluEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As the recent flu outbreak continues to capture our attention, the seasonal flu season in the southern hemisphere is about to start. Read about a new technique for tracing the global spread of flu. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - April 30, 2009 Category: Biomedical Science Source Type: consumer

'Fuzzy' Modeling Approach Sharpens View of Cellular Decision-MakingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Our cells are constantly bombarded with chemical messages. Inside the cells, complex signaling networks interpret the messages to make life-and-death decisions. To find out how these decisions are made, scientists turned to a technique developed in the 1960s and applied in auto-focusing cameras and cruise control in cars. It’s called fuzzy logic. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - April 16, 2009 Category: Biomedical Science Source Type: consumer

Ravi Iyengar on Molecular SystemsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ravi Iyengar says his favorite hobby is science. Good thing it’s also his full-time job. Trained as a biochemist, Iyengar has spent much of his career studying molecules and developing a list of all the parts that help a cell function. Now he is committed to figuring out how and why those parts work together. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - March 30, 2009 Category: Biomedical Science Source Type: consumer

Gene Teams Help Govern Sleep PatternsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
You've probably noticed how diverse peoples' sleep patterns are. There are night people and morning people, those who cat nap and those who can't stand the thought of a day time snooze. A new study in fruit flies suggests that an individual's sleep habits may be hardwired in their genes. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - March 18, 2009 Category: Biomedical Science Source Type: consumer

Math Gives BloodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Every year, two million Americans start taking a drug called warfarin. The amount each person needs varies greatly, and doctors typically use a trial and error approach to determine the appropriate dose for each patient. Thanks to mathematical modeling, researchers may have a gene-based approach that could quickly identify each person’s optimal dose. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - February 25, 2009 Category: Biomedical Science Source Type: consumer

Salvaging Signals for HealthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Automakers use steel scraps to build cars, construction companies repurpose tires to lay running tracks and now scientists are reusing previously discarded medical data to better understand our complex physiology. Through a Web site called PhysioNet, they can find important health information to shed light on the health of our hearts, minds and bodies. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - February 2, 2009 Category: Biomedical Science Source Type: consumer

Making a Microscopic MetropolisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
While you were busy making holiday shopping lists and checking them twice, we at Computing Life were busy compiling another list: reasons to develop computational or mathematical models. The list includes just 10 of the reasons expert Joshua Epstein gave to anthropologists, psychologists, neurobiologists, and others who met recently to talk about modeling social behavior. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - January 7, 2009 Category: Biomedical Science Source Type: consumer

Making a Microscopic MetropolisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Run your tongue across your teeth. Unless you've brushed recently, you probably feel a slimy residue. It’s a well-organized collection of bacteria called a biofilm. But how do these communities form? Watch a computer simulation developed by researchers at the University of California, San Diego that shows how a handful of bacteria can turn into a very orderly arrangement. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - December 22, 2008 Category: Biomedical Science Source Type: consumer

Tracking Bacteria in the BloodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Like a cannonball shooting through the air, bacteria follow similar mathematical rules as they shuttle through blood vessels. By using these rules to model where they go, emergency medicine researcher and doctor John Younger hopes to give us a better understanding of bacterial bloodstream infections--and teach his students that math is vital to understanding disease. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - November 26, 2008 Category: Biomedical Science Source Type: consumer

Virtual Screening Leads to Real Progress in Drug DesignEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Around 150,000 people per year get African sleeping sickness but the only medicines to treat it are either difficult to administer, expensive, or toxic. Now, a team of scientists has put computers to work to find a solution. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - October 28, 2008 Category: Biomedical Science Source Type: consumer

Teamwork Opens Evolutionary WindowEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two minds are often better than one, and the same goes for scientific techniques. Researchers who experiment in the lab are finding that computational methods can help them solve biological problems. Enzymologist Lizbeth Hedstrom and computational biochemist Wei Yang joined forces to open a window into the mysteries of evolution. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - October 22, 2008 Category: Biomedical Science Source Type: consumer

Now Open for Drug ChemistryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Penicillin was discovered by accident when mold drifted down on a petri dish and killed bacteria on it. Today, researchers can use computers to identify new therapeutic compounds, making drug discovery faster and cheaper. But as with most technologies, there's always room for improvement. By getting back to the basics, a new project plans to give computer-aided drug design a boost. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - October 9, 2008 Category: Biomedical Science Source Type: consumer

Modeling for New ResearchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers use models for many reasons, like predicting how a living system behaves or exploring questions nearly impossible to answer in the lab. Alissa Weaver uses them to generate new hypotheses--and results. Her latest work could explain why women with denser breast tissue typically have more aggressive tumors. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - September 24, 2008 Category: Biomedical Science Source Type: consumer

What's Your Science IQ?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Test your knowledge of computational biology by taking this fun and interactive quiz, which was originally developed as a learning tool for students who use free NIGMS publications like Computing Life to understand scientific concepts. You can find all the answers by reading the featured topics below. Need the accessible version? (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - September 10, 2008 Category: Biomedical Science Source Type: consumer

Walking the LineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
When we walk, muscles and nerves interact in intricate ways to let us take a step. This simulation, which is based on data from a 6-foot-tall man, shows what happens. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - August 27, 2008 Category: Biomedical Science Source Type: consumer

Q&A: Gus Rosania on Virtual Drug DevelopmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
When Colombian Gus Rosania came to the United States for college, he never thought he'd be a pharmaceutical scientist living in Michigan. Today he studies how small drug molecules make their way to the right cellular target and produce the desired effect. Read the Q&A to find out how he's using computational tools to help speed drug discovery. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - August 13, 2008 Category: Biomedical Science Source Type: consumer

Videocast: Geneticist Sarah Tishkoff on Human Genetic DiversityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Computer simulations allow researchers to study patterns of genetic variation in modern populations by making inferences about past events. Hear how one scientist is using this method to determine when some of us developed the ability to digest milk. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - July 23, 2008 Category: Biomedical Science Source Type: consumer

Engineering an EcosystemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New research is unveiling predator-prey interactions in a place much smaller than the Serengeti--a petri dish. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - July 9, 2008 Category: Biomedical Science Source Type: consumer

Protein PuzzlersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rather than chasing bad guys and monsters, gamers can now spend screen time helping scientists figure out protein folding. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - June 25, 2008 Category: Biomedical Science Source Type: consumer

Following FluEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers used computer modeling to map the spread of flu throughout the year. The method offers a new approach for detecting emerging strains of flu and making vaccines that protect us from seasonal flu. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - June 11, 2008 Category: Biomedical Science Source Type: consumer

Computing Evolutionary Trees Using Ancient MoleculesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Computational tools help prove dinosaurs and chickens are close relatives. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - May 28, 2008 Category: Biomedical Science Source Type: consumer

Interactive Crossword PuzzleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Solve the clues of computing life in this interactive crossword puzzle. Accessible version. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - April 7, 2008 Category: Biomedical Science Source Type: consumer