National Institutes of Health (NIH)
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366971 records returned
Impairment of mitochondrial respiration in mouse fibroblasts by oncogenic H-RAS(Q61L).
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A common metabolic change in cancer is the acquisition of glycolytic phenotypes. Increased expression of glycolytic enzymes is considered as one contributing factor. The role of mitochondrial defects in acquisition of glycolytic phenotypes has been postulated but remains controversial. Here we show that functional defects in mitochondrial respiration could be induced by oncogenic H-Ras(Q61L) transformation, even though the mitochondrial contents or mass was not reduced in the transformed cells. First, mitochondrial respiration, as measured by mitochondrial oxygen consumption, was suppressed in NIH-3T3 cells transformed...
Source: Cancer Biology and Therapy - November 20, 2009 Category: Cancer & Oncology Authors: Yang D, Wang MT, Tang Y, Chen Y, Jiang H, Jones TT, Rao K, Brewer GJ, Singh KK, Nie D Tags: Cancer Biol Ther Source Type: journals
The Next Generation of Colloids: Ready for "Prime Time"?Email this article to a colleague.
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PMID: 19923493 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Nussmeier NA, Searles BE Tags: Anesth Analg Source Type: journals
Intravenous Lidocaine for Ambulatory Anesthesia: Good to Go or Not So Fast?Email this article to a colleague.
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PMID: 19923494 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Wu CL, Liu SS Tags: Anesth Analg Source Type: journals
Difficult Mask Ventilation: What Needs Improvement?Email this article to a colleague.
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PMID: 19923495 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Salem MR, Ovassapian A Tags: Anesth Analg Source Type: journals
The Ultimate Difficult Airway: Minimizing Emergency Surgical Access.Email this article to a colleague.
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PMID: 19923496 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Fisher QA Tags: Anesth Analg Source Type: journals
Intracranial Pressure, Brain Vessels, and Consciousness Recovery in Traumatic Brain Injury.Email this article to a colleague.
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PMID: 19923497 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Stocchetti N Tags: Anesth Analg Source Type: journals
CON: Temperature Regimens and Neuroprotection During Cardiopulmonary Bypass: Does Rewarming Rate Matter?Email this article to a colleague.
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PMID: 19923498 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Cook DJ Tags: Anesth Analg Source Type: journals
PRO: Temperature Regimens and Neuroprotection During Cardiopulmonary Bypass: Does Rewarming Rate Matter?Email this article to a colleague.
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PMID: 19923499 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Grocott HP Tags: Anesth Analg Source Type: journals
A Core Review of Temperature Regimens and Neuroprotection During Cardiopulmonary Bypass: Does Rewarming Rate Matter?Email this article to a colleague.
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Despite a half century of research and the implementation of various risk-reduction strategies among clinicians and basic scientists, patients continue to experience strokes and cognitive dysfunction related to the use of cardiopulmonary bypass (CPB) for cardiac surgery. One strategy to reduce these detrimental effects has been the use of hypothermia. Although numerous studies have addressed the issue, the question of whether the use of hypothermia during CPB attenuates the impact of central nervous system consequences remains unresolved. However, data clearly demonstrate that hyperthermia is to be avoided in the perio...
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Grigore AM, Murray CF, Ramakrishna H, Djaiani G Tags: Anesth Analg Source Type: journals
Radial Artery Cannulation: A Comprehensive Review of Recent Anatomic and Physiologic Investigations.Email this article to a colleague.
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Consistent anatomic accessibility, ease of cannulation, and a low rate of complications have made the radial artery the preferred site for arterial cannulation. Radial artery catheterization is a relatively safe procedure with an incidence of permanent ischemic complications of 0.09%. Although its anatomy in the forearm and the hand is variable, adequate collateral flow in the event of radial artery thrombosis is present in most patients. Harvesting of the radial artery as a conduit for coronary artery bypass grafting, advances in plastic and reconstructive surgery of the hand, and its use as an entry site for cardiac ...
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Brzezinski M, Luisetti T, London MJ Tags: Anesth Analg Source Type: journals
Cardiac Anesthesia: Thirty Years Later--The Second Annual Arthur E. Weyman Lecture.Email this article to a colleague.
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Cardiac anesthesiology has evolved spectacularly over the past 30 yr, changing from a practice focused on the anesthetic management of patients with cardiovascular diseases to a practice of cardiovascular medicine that contributes to the medical and surgical management of cardiovascular patients. The second Weyman lecture reviews this history, the critical role of the Society of Cardiovascular Anesthesiologists in the evolution of the specialty, and the prospects for continued development for the specialty, the society, and the patients they care for.
PMID: 19923503 [PubMed - as supplied by publisher] (Source: Anes...
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Thys DM Tags: Anesth Analg Source Type: journals
Difficult Mask Ventilation.Email this article to a colleague.
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Mask ventilation is the most fundamental skill in airway management. In this review, we summarize the current knowledge about difficult mask ventilation (DMV) situations. Various definitions for DMV have been used in the literature. The lack of a precise standard definition creates a problem for studies on DMV and causes confusion in data communication and comparisons. DMV develops because of multiple factors that are technique related and/or airway related. Frequently, the pathogenesis involves a combination of these factors interacting to cause the final clinical picture. The reported incidence of DMV varies widely (...
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: El-Orbany M, Woehlck HJ Tags: Anesth Analg Source Type: journals
Systemic Remifentanil for Labor Analgesia.Email this article to a colleague.
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There is a need for safe, effective, and easy-to-administer systemic analgesia that ideally has rapid onset and offset, matches the time course of uterine contractions, and does not compromise the fetus. Although neuraxial blockade is the "gold standard" for labor analgesia, systemic analgesia is useful in those cases in which neuraxial analgesia is contraindicated, refused or simply not needed by the parturient, or when skilled anesthesia providers are not available. Because of its unique pharmacologic properties, remifentanil has been investigated, and is used clinically, to provide IV labor analgesia. In this focuse...
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Hinova A, Fernando R Tags: Anesth Analg Source Type: journals
Clinical Implications of Neuraxial Anesthesia in the Parturient with Scoliosis.Email this article to a colleague.
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Scoliosis can pose challenges to the initiation and function of neuraxial anesthetics. We reviewed the available literature exploring neuraxial techniques in parturients with uncorrected or corrected (i.e., surgically instrumented) scoliosis. The 22 articles reported 117 attempted neuraxial procedures (uncorrected n = 24 and corrected n = 93). Of these procedures, 79% of uncorrected patients and 69% of corrected patients were successfully managed with neuraxial anesthesia. Procedures were typically more challenging in corrected patients; 90% of all reported difficulties in this subgroup involved epidural anesthetics. C...
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Ko JY, Leffert LR Tags: Anesth Analg Source Type: journals
Perioperative Management of the Adult with Cystic Fibrosis.Email this article to a colleague.
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Since cystic fibrosis (CF) was first differentiated from celiac disease in 1938, the medical care of patients with CF has substantially improved. These improvements have resulted in a significant increase in median survival and the quality of life experienced by patients. The resultant increase in survival has caused the "average" CF patient to be a young adult and not a child. The gene that causes CF was first identified in 1989 and is the first gene discovered by positional cloning. Unfortunately, gene therapy for CF has not been successful, although it continues to hold great promise for future patient care. Althoug...
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Huffmyer JL, Littlewood KE, Nemergut EC Tags: Anesth Analg Source Type: journals
Primum Non Nocere.Email this article to a colleague.
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PMID: 19923537 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Ellison N, Jobes DR, Schwartz AJ Tags: Anesth Analg Source Type: journals
Clarification of Issues Regarding Manometry for Central Venous Catheterization.Email this article to a colleague.
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PMID: 19923538 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Ibinson JW, Oravitz TM, Ezaru CS, Mangione MP Tags: Anesth Analg Source Type: journals
Ultrasound-Guided Central Venous Cannulation: False Sense of Security.Email this article to a colleague.
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PMID: 19923540 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Mittnacht AJ Tags: Anesth Analg Source Type: journals
Pressure Waveform Monitoring During Central Venous Catheterization.Email this article to a colleague.
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PMID: 19923541 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Bowdle A, Kharasch E, Schwid H Tags: Anesth Analg Source Type: journals
Is a Different Dose of Anesthesia the Real Problem?Email this article to a colleague.
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PMID: 19923542 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Royse CF Tags: Anesth Analg Source Type: journals
Communication Between Two Channels of Central Venous Catheter: A Rare Manufacturing Defect.Email this article to a colleague.
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PMID: 19923543 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Hegde HV, Sachidananda R, Rao RP, Deshapande SS Tags: Anesth Analg Source Type: journals
Resistive Index May Not Accurately Reflect Renal Flow Resistance in the Presence of Significant Aortic Insufficiency.Email this article to a colleague.
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PMID: 19923544 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Yang PL, Wong DT Tags: Anesth Analg Source Type: journals
Board Stiff Three: Preparation for Anesthesia Orals, with DVD, 3rd ed.Email this article to a colleague.
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PMID: 19923545 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Yumul R, Wender RH Tags: Anesth Analg Source Type: journals
Pain Review.Email this article to a colleague.
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PMID: 19923546 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: McKay WR Tags: Anesth Analg Source Type: journals
Society for Obstetric Anesthesia and Perinatology, 2009 Annual Meeting Summary: Washington, DC, April 29 to May 3, 2009.Email this article to a colleague.
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PMID: 19923547 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Ellinas EH Tags: Anesth Analg Source Type: journals
GUEST REVIEWERS: APRIL 1, 2009-September 30, 2009.Email this article to a colleague.
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Authors:
PMID: 19923548 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Tags: Anesth Analg Source Type: journals
Comment on "TLR9-Dependent Activation of Dendritic Cells by DNA from Leishmania major Favors Th1 Cell Development and the Resolution of Lesions"Email this article to a colleague.
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PMID: 19923471 [PubMed - as supplied by publisher] (Source: Journal of Immunology)
Source: Journal of Immunology - November 20, 2009 Category: Allergy & Immunology Authors: Bogdan C, Schleicher U Tags: J Immunol Source Type: journals
A Crucial Door to the Mast Cell Mystery Knocked In.Email this article to a colleague.
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PMID: 19923472 [PubMed - as supplied by publisher] (Source: Journal of Immunology)
Source: Journal of Immunology - November 20, 2009 Category: Allergy & Immunology Authors: Kawakami T Tags: J Immunol Source Type: journals
Pillars Article: Fate of Bone Marrow-Derived Cultured Mast Cells After Intracutaneous, Intraperitoneal, And Intravenous Transfer Into Genetically Mast Cell-Deficient W/Wv Mice. Evidence That Cultured Mast Cells Can Give Rise To Both Connective Tissue Type And Mucosal Mast Cells. The Journal of Experimental Medicine. 1985. 162: 1025-1043.Email this article to a colleague.
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PMID: 19923473 [PubMed - as supplied by publisher] (Source: Journal of Immunology)
Source: Journal of Immunology - November 20, 2009 Category: Allergy & Immunology Authors: Nakano T, Sonoda T, Hayashi C, Yamatodani A, Kanayama Y, Yamamura TI, Asai H, Yonezawa T, Kitamura Y, Galli SJ Tags: J Immunol Source Type: journals
What Role Does the Route of Immunization Play in the Generation of Protective Immunity against Mucosal Pathogens?Email this article to a colleague.
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The route of vaccination is important in influencing immune responses at the initial site of pathogen invasion where protection is most effective. Immune responses required for mucosal protection can differ vastly depending on the individual pathogen. For some mucosal pathogens, including acute self-limiting infections, high-titer neutralizing Abs that enter tissue parenchyma or transude into the mucosal lumen are sufficient for clearing cell-free virus. However, for pathogens causing chronic infections such as HIV, hepatitis C virus, herpes viruses, mycobacteria, and fungal and parasitic infections, a single arm of th...
Source: Journal of Immunology - November 20, 2009 Category: Allergy & Immunology Authors: Belyakov IM, Ahlers JD Tags: J Immunol Source Type: journals
The rate of consanguineous marriages among parents of schizophrenic patients in the Arab Bedouin population in Southern Israel.Email this article to a colleague.
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Consanguinity may contribute to the incidence of schizophrenia in offspring despite the usually accepted polygenic model of schizophrenia inheritance. Bedouin Arab families in southern Israel have a high rate of cousin marriages as do families throughout most Arab societies. We studied consanguinity in the parents of schizophrenic patients admitted in a defined catchment area of southern Israel, compared to a control group of parents of all infants born to Bedouin mothers in this catchment area. There was a small but significant increase in the rate of cousin marriages among the parents of schizophrenia patients compar...
Source: The World Journal of Biological Psychiatry - November 20, 2009 Category: Psychiatry Authors: Dobrusin M, Weitzman D, Levine J, Kremer I, Rietschel M, Maier W, Belmaker RH Tags: World J Biol Psychiatry Source Type: journals
Association between the ionotropic glutamate receptor kainate3 (GRIK3) Ser310Ala polymorphism and schizophrenia in the Indian population.Email this article to a colleague.
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Various studies have been done to check the status of glutamate receptor gene in the pathogenesis of schizophrenia. The T928G (Ser310Ala) polymorphism of ionotropic glutamate receptor kainate 3 gene (GRIK3) and its positive association with schizophrenia was reported in Caucasians, whereas no association of this polymorphism with schizophrenia was shown in two other populations, Chinese and Japanese. However, no literature is available regarding the prevalence of this polymorphism and its association with schizophrenia in the Indian population. As genetic susceptibility profiles in India are often different from those ...
Source: The World Journal of Biological Psychiatry - November 20, 2009 Category: Psychiatry Authors: Ahmad Y, Bhatia MS, Mediratta PK, Sharma KK, Negi H, Chosdol K, Sinha S Tags: World J Biol Psychiatry Source Type: journals
Pro-inflammatory biomakers in depression: Treatment with venlafaxine.Email this article to a colleague.
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High levels of pro-inflammatory biomarkers have been reported in depression. In the present study, five pro-inflammatory biomarkers were measured in the blood of patients with major depressive disorder (MDD). Biomarker levels were compared to age- and sex-matched healthy subjects. Patients with MDD had significantly higher baseline levels of tumour necrosis factor-alpha (TNFalpha, P=0.04), interleukin-1beta (IL1beta, P=0.03), and monocyte chemotactic protein-1 (MCP-1; P=0.02) compared to controls. There were no differences between groups in levels of cell determinant-40 ligand (CD40L) and C-reactive protein (CRP). A su...
Source: The World Journal of Biological Psychiatry - November 20, 2009 Category: Psychiatry Authors: Piletz JE, Halaris A, Iqbal O, Hoppensteadt D, Fareed J, Zhu H, Sinacore J, Devane CL Tags: World J Biol Psychiatry Source Type: journals
Self-poisonings with tricyclic antidepressants and selective serotonin reuptake inhibitors in Tehran, Iran.Email this article to a colleague.
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This study suggests that an overdose with SSRIs results in a more favourable clinical outcome than an overdose with TCAs.
PMID: 19921972 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - November 20, 2009 Category: Psychiatry Authors: Naderi-Heiden A, Shadnia S, Salimi AR, Naderi A, Naderi MM, Schmid D, Gleiss A, Kasper S, Frey R Tags: World J Biol Psychiatry Source Type: journals
Neurotrophic factors in serum following ECT: A pilot study.Email this article to a colleague.
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We examined changes in serum levels of a selection of neurotrophic factors, TSH, HGH and cortisol in conjunction with ECT treatment. Fifteen patients suffering from affective disorders were included, all were treated with antidepressants and psychotherapy and 10 also with ECT. The patients were examined clinically and with blood samples during treatment. Serum levels of cortisol, thyroid stimulating hormone (TSH), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3), neuropetide Y (NPY) and human growth hormone (HGH) were studied. No significant changes were found in levels of NGF, BDNF...
Source: The World Journal of Biological Psychiatry - November 20, 2009 Category: Psychiatry Authors: Grønli O, Stensland GO, Wynn R, Olstad R Tags: World J Biol Psychiatry Source Type: journals
Longitudinal changes of day-time and night-time gross motor activity in clinical responders and non-responders of major depression.Email this article to a colleague.
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This study investigates the development of day- and night-time as well as intensity and quantity of circadian motor activity during a 4-week course of treatment among 27 patients with depression compared to 27 healthy controls. A diagnosis of major depression was made using SCID. Motor activity was continuously measured with an actigraph during the study and clinical course of depression with HAM-D-21. Motor activity was described as the quantity and intensity of movements during day- and night- time. Clinically improved patients had significantly intensified movements after 4 weeks, compared to subjects with <50% impro...
Source: The World Journal of Biological Psychiatry - November 20, 2009 Category: Psychiatry Authors: Todder D, Caliskan S, Baune BT Tags: World J Biol Psychiatry Source Type: journals
Sleep disturbances: Core symptoms of major depressive disorder rather than associated or comorbid disorders.Email this article to a colleague.
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Depression is increasingly prevalent in Western countries. It has severe consequences and is associated with increased rates of disability, morbidity, and mortality. Despite numerous therapeutic options, a great number of depressed patients do not achieve full remission. In addition, despite good short-term outcomes, long-term therapeutic results remain disappointing and associated with a poor prognosis, raising significant concern in terms of public health. Impaired sleep - especially insomnia - may be at least partly responsible for this problem. Very close relationships between major depressive disorder (MDD) and sl...
Source: The World Journal of Biological Psychiatry - November 20, 2009 Category: Psychiatry Authors: Mendlewicz J Tags: World J Biol Psychiatry Source Type: journals
Tryptophan as an evolutionarily conserved signal to brain serotonin: Molecular evidence and psychiatric implications.Email this article to a colleague.
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The role of serotonin (5-HT) in psychopathology has been investigated for decades. Among others, symptoms of depression, panic, aggression and suicidality have been associated with serotonergic dysfunction. Here we summarize the evidence that low brain 5-HT signals a metabolic imbalance that is evolutionarily conserved and not specific for any specific psychiatric diagnosis. The synthesis and neuronal release of brain 5-HT depends on the concentration of free tryptophan in blood and brain because the affinity constant of neuronal tryptophan hydroxylase is in that concentration range. This relationship is evolutionarily...
Source: The World Journal of Biological Psychiatry - November 20, 2009 Category: Psychiatry Authors: Russo S, Kema IP, Bosker F, Haavik J, Korf J Tags: World J Biol Psychiatry Source Type: journals
The World Journal of Biological Psychiatry.Email this article to a colleague.
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PMID: 19921966 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - November 20, 2009 Category: Psychiatry Authors: Kasper S Tags: World J Biol Psychiatry Source Type: journals
DDM - An Attitude of Excellence: How to Succeed at Work and at Home (NIH Only)Email this article to a colleague.
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2008-2009 Deputy Director for Management (DDM) Seminar Series
The DDM Seminar Series is open to all NIH employees and there is no need to pre-register for the event.
http://www.ddmseries.od.nih.govAir date: 12/3/2009 11:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - November 20, 2009 Category: Journals (General) Tags: Upcoming Events Source Type: events
Self-killing of melanoma cells by cytosolic delivery of dsRNA: Wiring innate immunity for a coordinated mobilization of endosomes, autophagosomes and the apoptotic machinery in tumor cells.Email this article to a colleague.
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Patients with metastatic melanoma have a poor prognosis, primarily due to a generalized inefficacy of current anticancer treatments. Therefore, the identification of novel death inducers with good bioavailability and safety profiles is a main priority in this disease. Here we summarize recent work from our group uncovering an unexpected ability of the dsRNA mimic polyinosine-polycytidylic acid (pIC) to engage the endo/lysosomal machinery of melanoma cells and induce their self degradation by autophagy and apoptosis, without noticeable secondary effects in vivo. However the antimelanoma activity of pIC strictly required...
Source: Autophagy - November 20, 2009 Category: Cytology Authors: Alonso-Curbelo D, Soengas MS Tags: Autophagy Source Type: journals
The cysteine protease MoAtg4 interacts with MoAtg8 and is required for differentiation and pathogenesis in Magnaporthe oryzae.Email this article to a colleague.
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Atg4 is a unique cysteine protease responsible for the cleavage of the carboxyl terminus of Atg8 during the formation of autophagosomes in yeast. Here we report that MoAtg4, an Atg4 homologue in Magnaporthe oryzae, controls cell differentiation and pathogenicity by interacting with MoAtg8, an autophagic protein essential for autophagic cell death and pathogenicity. Yeast complementation assay revealed that MoATG4 can functionally complement the defects of the yeast ATG4 deletion mutant. The direct interaction between MoAtg4 and MoAtg8 was detected in both yeast two hybrid and bimolecular fluorescence complementation (B...
Source: Autophagy - November 20, 2009 Category: Cytology Authors: Liu TB, Liu XH, Lu JP, Zhang L, Min H, Lin FC Tags: Autophagy Source Type: journals
Investigating autophagy: Quantitative morphometric analysis using electron microscopy.Email this article to a colleague.
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Autophagy is a compensatory pathway involving isolation and subsequent degradation of cytosolic material and organelles in eukaryotic cells.(1) The autophagic process can provide a "housekeeping" function by removing damaged proteins and organelles in a selective or nonselective fashion in order to exert a protective effect following stress.(2) Remarkably, after being discovered to be much more of a targeted process than a random one, the role of autophagy became implicated in many normal cellular and disease processes.(3) Several methodologies are routinely employed to monitor the entire autophagic process.(4) Microtu...
Source: Autophagy - November 20, 2009 Category: Cytology Authors: Swanlund JM, Kregel KC, Oberley TD Tags: Autophagy Source Type: journals
Autophagy augmented by troglitazone is independent of EGFR transactivation and correlated with AMP-activated protein kinase signaling.Email this article to a colleague.
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We report here that troglitazone augments AMP-activated protein kinase-alpha (AMPKalpha) phosphorylation, reduces p70S6 kinase phosphorylation and stimulates autophagy that is independent of EGFR expression and transactivation. Troglitazone stimulus reduced neither lysosomal staining nor GFP-LC3 dots of HeLa cells, when the cells pretreated with AG1478, a specific EGFR kinase inhibitor. Furthermore, AG1478 additively enhanced the troglitazone-induced degradation of sequestosome 1 (SQSTM1/p62), which is a selective substrate of autophagy. Inhibition of AMPKalpha activity either by compound C or by RNA interference markedly ...
Source: Autophagy - November 20, 2009 Category: Cytology Authors: Yan J, Yang H, Wang G, Sun L, Zhou Y, Guo Y, Xi Z, Jiang X Tags: Autophagy Source Type: journals
The Polyhomeotic protein induces hyperplastic tissue overgrowth through the activation of the JAK/STAT pathway.Email this article to a colleague.
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Epigenetic mechanisms controlling cellular proliferation are essential to animal development. Moreover, altered levels of expression of the epigenetic regulator proteins are associated with the development and progression of human diseases like cancer. We have studied the effects of high levels of Polyhomeotic (PH) protein, a member of the Polycomb Group (PcG), during the proliferation of the imaginal discs in Drosophila. Overexpression of PH protein causes induction of proliferation, accompanied with induction of JNK-dependent apoptosis. As a result, massive hyperplastic overgrowth is produced and the corresponding di...
Source: Cell Cycle - November 20, 2009 Category: Cytology Authors: González I, Simón R, Busturia A Tags: Cell Cycle Source Type: journals
My family’s story: surviving swine fluEmail this article to a colleague.
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Thanks to H1N1, Halloween came on November 15 for the Lord and Ladies of the Cyr household
My wife, Sara, and I are the proud parents of newly minted 4-year-old triplets, and this fall we just haven’t been able to get healthy in our house. We get over one illness and another one crops up a week later. Fevers come and go. Coughs are incessant. Headaches bloom and recede. It’s been never-ending.
So none of us was feeling particularly well on the Thursday before Halloween when Sara called me at work and told me she had spiked a fever. We weren’t sure it was H1N1, but working in the Public Affairs Department here at Ch...
Source: Thrive, Children's Hospital Boston - November 20, 2009 Category: Pediatrics Authors: Matt Cyr Tags: H1N1 (swine flu) One parent's story Flu vaccine seasonal flu swine flu vaccine Vaccines Source Type: organizations
Genetic ablation of caveolin-1 increases neural stem cell proliferation in the subventricular zone (SVZ) of the adult mouse brain.Email this article to a colleague.
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In this study, dual-label immunofluorescence analysis of the proliferation marker, Ki67, and the stem cell markers, nestin and Sox2, was performed on brains of 8 week-old wild-type (WT) and Cav-1 knockout (KO) mice. Our results demonstrate an increased number of Ki67-positive nuclei in the subventricular zone (SVZ) of Cav-1 KO brains. Importantly, our dual-label immunofluorescence analyses demonstrate increased co-localization of Ki67 with both nestin and Sox2 in the SVZ of Cav-1 KO brains. Remarkably similar results were also obtained with Cav-2 and Cav-3 KO mouse brains as well, with increased proliferation of adult neur...
Source: Cell Cycle - November 20, 2009 Category: Cytology Authors: Jasmin JF, Yang M, Iacovitti L, Lisanti MP Tags: Cell Cycle Source Type: journals
Potential Strategy To Help Generate HIV-Neutralizing AntibodiesEmail this article to a colleague.
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WHAT: New discoveries about anti-HIV antibodies may bring researchers a step closer to creating an effective HIV vaccine, according to a new paper co-authored by scientists at the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: HIV / AIDS Source Type: news
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PMID: 19919757 [PubMed - as supplied by publisher] (Source: Clio Medica)
Source: Clio Medica - November 20, 2009 Category: History of Medicine Authors: Kichigina G Tags: Clio Med Source Type: journals
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PMID: 19919756 [PubMed - as supplied by publisher] (Source: Clio Medica)
Source: Clio Medica - November 20, 2009 Category: History of Medicine Authors: Kichigina G Tags: Clio Med Source Type: journals
