Nanomedicine
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The future of theranostic nanoagents.
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PMID: 19839803 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - September 30, 2009 Category: Nanotechnology Authors: McCarthy JR Tags: Nanomed Source Type: journals
News & views in ... Nanomedicine.
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News & views in ... Nanomedicine.
Nanomed. 2009 Oct;4(7):697-700
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PMID: 19839804 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - September 30, 2009 Category: Nanotechnology Tags: Nanomed Source Type: journals
Research highlights.
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PMID: 19839805 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - September 30, 2009 Category: Nanotechnology Authors: Kim JS, Low V, Richards J Tags: Nanomed Source Type: journals
Conference scene: 2nd annual European conference for clinical nanomedicine.
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The 2nd European Conference for Clinical Nanomedicine (European CLINAM Conference) was held in April 2009 in Basel, Switzerland, and is the annual scientific conference of the European Foundation for Clinical Nanomedicine (European CLINAM Foundation) and the European Society for Nanomedicine. The meeting brings together clinicians and nanoscientists with the common vision of applying nanoscience methods, tools and materials for the benefit of the patient. This year's topics were unsolved medical problems in the fields of cardiology, oncology, neurology/neurosurgery, dermatology, orphan diseases, orthopedics and implant...
Source: Nanomedicine - September 30, 2009 Category: Nanotechnology Authors: Löffler B Tags: Nanomed Source Type: journals
Conference Scene: Innovative medical devices and nanotechnology: 1-day interactive workshop.
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The Institute of Nanotechnology, in collaboration with the University of Sheffield, organized this 1-day interactive workshop held at the Kroto Institute, Sheffield University North Campus, Sheffield, UK. The workshop provided a showcase of innovative and exciting new medical nanotechnologies. The topics addressed included diagnostics and imaging, tissue engineering, polymer therapeutics and drug delivery, and drug discovery and screening. The workshop was attended by clinicians, medical researchers, industry experts, healthcare managers, academics and students. The workshop was divided into four sessions: regenerative...
Source: Nanomedicine - September 30, 2009 Category: Nanotechnology Authors: Moore R, Battaglia G Tags: Nanomed Source Type: journals
Efficacy of niosomal formulation of diallyl sulfide against experimental candidiasis in Swiss albino mice.
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Conclusion: Incorporation of DAS in niosomes enhances its antifungal efficacy. Further studies are needed to optimize the current findings to develop an efficient nature-derived alternative antifungal therapeutic strategy.
PMID: 19839808 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - September 30, 2009 Category: Nanotechnology Authors: Alam M, Dwivedi V, Khan AA, Mohammad O Tags: Nanomed Source Type: journals
Biologic nanoparticles and platelet reactivity.
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Conclusion: Effects of bovine-derived and hydroxyapatite NPs on basal release of ATP were both time and concentration dependent. These results suggest that biologic NPs modulate both platelet aggregation and secretion. Biologically derived NPs could modify platelet responses within the vasculature, thereby reducing blood coagulability and the vascular response to injury.
PMID: 19839809 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - September 30, 2009 Category: Nanotechnology Authors: Miller VM, Hunter LW, Chu K, Kaul V, Squillace PD, Lieske JC, Jayachandran M Tags: Nanomed Source Type: journals
Platelet compatibility of PLGA, chitosan and PLGA-chitosan nanoparticles.
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Aim: The increasing interest in biodegradable nanoparticles containing biomaterials such as poly(D,L-lactide-co-glycolide) (PLGA) and chitosan for drug delivery raises issues regarding the blood compatibility of these nanoparticles, since some nanoparticles, including carbon nanoparticles, can affect human platelet aggregation and cause vascular thrombosis. Therefore, the aim of this work was to investigate the effect of polymeric nanoparticles on human platelet function by measuring aggregation and receptor expression in vitro. Materials & method: PLGA, chitosan-PLGA and a series of chitosan nanoparticles were pre...
Source: Nanomedicine - September 30, 2009 Category: Nanotechnology Authors: Li X, Radomski A, Corrigan OI, Tajber L, De Sousa Menezes F, Endter S, Medina C, Radomski MW Tags: Nanomed Source Type: journals
Imaging and organelle distribution of fluorescent InGaP/ZnS nanoparticles in glial cells.
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Conclusion: These results suggest that the availability of mono-unsaturated fatty acids, such as oleic acid, in different cells could significantly alter nanoparticle uptake and localization, which can in turn affect the functions of cells and tissues coexposed to nanoparticles.
PMID: 19839811 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - September 30, 2009 Category: Nanotechnology Authors: Behrendt M, Sandros MG, McKinney RA, McDonald K, Przybytkowski E, Tabrizian M, Maysinger D Tags: Nanomed Source Type: journals
Imaging the distribution of individual platinum-based anticancer drug molecules attached to single-wall carbon nanotubes.
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Conclusion: Z-contrast STEM imaging provides a means for direct visualization of heavy metal containing molecules (i.e., cisplatin) attached to surfaces of carbon SWNTs along with distribution and quantitation.
PMID: 19839812 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - September 30, 2009 Category: Nanotechnology Authors: Bhirde AA, Sousa AA, Patel V, Azari AA, Gutkind JS, Leapman RD, Rusling JF Tags: Nanomed Source Type: journals
Optimization of physicochemical parameters influencing the fabrication of protein-loaded chitosan nanoparticles.
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Conclusion: Among the various types of lyoprotectants (natural and synthetic) examined, sucrose proved to be very effective in reducing the size of freeze-dried nanoparticles on redispersion without significant change in surface charge of nanoparticles. Finally, the in vitro release kinetics of BSA from nanoparticles of different molecular weights of chitosan, with and without sucrose, was evaluated and found to depend upon the molecular weight of chitosan.
PMID: 19839813 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - September 30, 2009 Category: Nanotechnology Authors: Vandana M, Sahoo SK Tags: Nanomed Source Type: journals
High-strength metal nanomagnets for diagnostics and medicine: carbon shells allow long-term stability and reliable linker chemistry.
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The rapidly growing applications of nanomagnets in magnetic drug delivery and separation in clinical diagnostics require strong and reliable magnetic vehicles. Strength conveys rapid processing, high delivery/targeting yield and rapid results when used in clinics. Reliability enables recycling of nanomagnets, regulatory-conforming drug formulations and efficient use of (expensive) antibodies in diagnostics, combined with reduced leaching (reagent loss). The present work illustrates how metal-based nanomagnets provide a two-three-times stronger magnetic particle than conventional magnetite-based materials. Ligands, anti...
Source: Nanomedicine - September 30, 2009 Category: Nanotechnology Authors: Herrmann IK, Grass RN, Stark WJ Tags: Nanomed Source Type: journals
Magnetically modulated nanosystems: a unique drug-delivery platform.
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Magnetic nanoparticles are attractive targets owing to their unique characteristics that are not shared by bulk materials. Magnetic particles, ranging from nanometer-sized to 1 microm in size, are being used in an increasing number of medical applications. The important properties of magnetic particles for medical applications are nontoxicity, biocompatiblilty, injectability and high-level accumulation in the target tissue or organ. Magnetic nanoparticles modified with organic molecules have been widely used for biotechnological and biomedical applications as their properties can be magnetically controlled by applying ...
Source: Nanomedicine - September 30, 2009 Category: Nanotechnology Authors: Barakat NS Tags: Nanomed Source Type: journals
Plasmonic nanoparticle-generated photothermal bubbles and their biomedical applications.
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This article is focused on the optical generation and detection of photothermal vapor bubbles around plasmonic nanoparticles. We report physical properties of such plasmonic nanobubbles and their biomedical applications as cellular probes. Our experimental studies of gold nanoparticle-generated photothermal bubbles demonstrated the selectivity of photothermal bubble generation, amplification of optical scattering and thermal insulation effect, all realized at the nanoscale. The generation and imaging of photothermal bubbles in living cells (leukemia and carcinoma culture and primary cancerous cells), and tissues (atheroscl...
Source: Nanomedicine - September 30, 2009 Category: Nanotechnology Authors: Lapotko D Tags: Nanomed Source Type: journals
Acknowledgements.
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PMID: 19839817 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - September 30, 2009 Category: Nanotechnology Tags: Nanomed Source Type: journals
Delivering the goods: realizing the clinical potential of RNAi.
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PMID: 19663585 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - July 31, 2009 Category: Nanotechnology Authors: Howard KA Tags: Nanomed Source Type: journals
The promise of nanomedicine for ocular disease.
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PMID: 19663586 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - July 31, 2009 Category: Nanotechnology Authors: Thomson H, Lotery A Tags: Nanomed Source Type: journals
Testing strategies for the safety of nanoparticles used in medical applications.
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Worth A, Palosaari T, Burello E, Housiadas C, Pilou M, Volkovova K, Tulinska J, Kazimirova A, Barancokova M, Sebekova K, Hurbankova M, Kovacikova Z, Knudsen L, Poulsen M, Mose T, Vilà M, Gombau L, Fernandez B, Castell J, Marcomini A, Pojana G, Bilanicova D, Vallotto D
PMID: 19663587 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - July 31, 2009 Category: Nanotechnology Authors: Dusinska M, Dusinska M, Fjellsbø L, Magdolenova Z, Rinna A, Runden Pran E, Bartonova A, Heimstad E, Harju M, Tran L, Ross B, Juillerat L, Halamoda Kenzaui B, Marano F, Boland S, Guadaginini R, Saunders M, Cartwright L, Carreira S, Whelan M, Kelin Ch, Tags: Nanomed Source Type: journals
News & views in ... Nanomedicine.
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News & views in ... Nanomedicine.
Nanomed. 2009 Aug;4(6):609-11
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PMID: 19663588 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - July 31, 2009 Category: Nanotechnology Tags: Nanomed Source Type: journals
Research Highlights.
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PMID: 19663589 [PubMed - as supplied by publisher] (Source: Nanomedicine)
Source: Nanomedicine - July 31, 2009 Category: Nanotechnology Authors: Ross L, Riehle M, McNamara L, Burchmore R, Dalby M, McMurray R, Gadegaard N, Ahmed S, Tsimbouri P Tags: Nanomed Source Type: journals
Conference Scene: Nanotechnology and medicine: the next big thing is really small.
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Emerging trends from nanotechnology on a globalized scale have created the need for a platform to discuss advances and share developments in this fast growing field. A conference was held to attract a vast number of scientists, representatives from nanotechnology vendor companies, and a diverse array of investors, businessmen and industry participants. The scope of the meeting was to discuss and share developments, innovations and research in the growing, but still emerging science of nanotechnology. The thrust of nanotechnology towards the development of personalized medicine, along with the enforced partnership betwe...
Source: Nanomedicine - July 31, 2009 Category: Nanotechnology Authors: Tasciotti E, Sakamoto J, Ferrari M Tags: Nanomed Source Type: journals
Potential novel drug carriers for inner ear treatment: hyperbranched polylysine and lipid nanocapsules.
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This study examined HBPL and LNCs for their cellular uptake and possible toxicity in vitro and in vivo as the first step in developing novel nanosized multifunctional carriers. Method: Having incubated HBPL and LNCs with fibroblasts, nanoparticle uptake and cell viability were determined by confocal laser scanning microscopy, fluorescence measurements and neutral red staining. In vivo, electrophysiology, confocal laser scanning microscopy and cytocochleograms were performed for nanoparticle detection and also toxicity studies after intracochlear application. Results: Both nanoparticles were detectable in the fibroblasts' c...
Source: Nanomedicine - July 31, 2009 Category: Nanotechnology Authors: Cheper V, Wolf M, Scholl M, Kadlecova Z, Perrier T, Klok HA, Saulnier P, Lenarz T, Stöver T Tags: Nanomed Source Type: journals
Rapid and sensitive microplate assay for screening the effect of silver and gold nanoparticles on bacteria.
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Background & aim: Nanomaterials are the leading requirement of the rapidly developing field of nanomedicine and bionanotechnology, and in this respect, nanotoxicology research is gaining great importance. In the field of infections, nanoparticles are being utilized as therapeutic tools against microbes, thus understanding the properties of nanoparticles and their effect on microbes is essential prior to clinical application. The aim of this study was to evaluate a microplate-based assay for monitoring the toxicity of silver and gold nanoparticles on bacteria. Method: Escherichia coli, a Gram-negative bacteria, and ...
Source: Nanomedicine - July 31, 2009 Category: Nanotechnology Authors: Amin RM, Mohamed MB, Ramadan MA, Verwanger T, Krammer B Tags: Nanomed Source Type: journals
Nanoparticle strategies for enhancing the sensitivity of fluorescence-based biochips.
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This article describes strategies for achieving fluorescence enhancement in optical biochips. Two strategies are discussed: plasmonic enhancement, which is due to the localized surface plasmon resonance of metal nanostructures that are adjacent to the fluorescent labels in optical immunoassays; and the use of high-brightness silica nanoparticles as enhanced labels. We present a review of the state-of-the-art in both areas, including synthesis techniques for the metal and silica nanoparticles and the use of the nanoparticles in optical immunoassays. Data are presented that highlight the key design parameters which influence...
Source: Nanomedicine - July 31, 2009 Category: Nanotechnology Authors: McDonagh C, Stranik O, Nooney R, Maccraith BD Tags: Nanomed Source Type: journals
Stimulus-responsive targeted nanomicelles for effective cancer therapy.
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This article will focus on recent advancements in the design of stimulus-responsive targeted nanomicelles loaded with anticancer drugs to fulfill the challenges associated with cancer cells (e.g., multidrug resistance) for the effective treatment of cancer. The significant toxicity issues and a possible future perspective associated with nanomicelles are also discussed here.
PMID: 19663594 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - July 31, 2009 Category: Nanotechnology Authors: Muthu MS, Rajesh CV, Mishra A, Singh S Tags: Nanomed Source Type: journals
The status of in vitro toxicity studies in the risk assessment of nanomaterials.
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Nanotechnology applications already on the market or in development promise great benefits for humans as well as the environment. Simultaneously, the pressure to advance the development of fast methods for evaluating the potential risks of increased human exposure to nanomaterials is augmented. One way forward would be to enhance the role of in vitro toxicity studies in risk assessment procedures of nanomaterials. However, to maximize the use of in vitro assays for this purpose, their values and limitations need to be revealed. Even in risk assessment frameworks for regular chemicals, in vitro studies play a minor role...
Source: Nanomedicine - July 31, 2009 Category: Nanotechnology Authors: Park MV, Lankveld DP, van Loveren H, de Jong WH Tags: Nanomed Source Type: journals
Acknowledgements.
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PMID: 19663596 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - July 31, 2009 Category: Nanotechnology Tags: Nanomed Source Type: journals
Regulatory and scientific barriers to the safety evaluation of medical nanotechnologies.
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PMID: 19572812 [PubMed - as supplied by publisher] (Source: Nanomedicine)
Source: Nanomedicine - June 30, 2009 Category: Nanotechnology Authors: Bhogal N Tags: Nanomed Source Type: journals
Brain targeting PBCA nanoparticles and the blood-brain barrier.
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PMID: 19572813 [PubMed - as supplied by publisher] (Source: Nanomedicine)
Source: Nanomedicine - June 30, 2009 Category: Nanotechnology Authors: Wilson B Tags: Nanomed Source Type: journals
News & Views in ... Nanomedicine.
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News & Views in ... Nanomedicine.
Nanomed. 2009 Jul;4(5):503-505
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PMID: 19572814 [PubMed - as supplied by publisher] (Source: Nanomedicine)
Source: Nanomedicine - June 30, 2009 Category: Nanotechnology Tags: Nanomed Source Type: journals
Research Highlights.
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PMID: 19572815 [PubMed - as supplied by publisher] (Source: Nanomedicine)
Source: Nanomedicine - June 30, 2009 Category: Nanotechnology Authors: Chan WC Tags: Nanomed Source Type: journals
Conference Scene: New perspectives on nanoneuroscience, nanoneuropharmacology and nanoneurotoxicology.
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The 6th GCNN Annual meeting was held in the Hilton Hotel, Vienna, Austria, on 1-4 March, 2009. In this conference a special focus was given to 'Nanomedicine: Nanoneuropharmacology and Nanoneurotoxicity' on 2-3 March, 2009. The 'Nanomedicine Focus' was organized by M Robertson (London, UK) and H Shanker Sharma (Uppsala, Sweden) and was divided into three sessions on 2 March, followed by one session on 3 March. In total, 11 speakers participated in these sessions covering more than 5 h of intensive presentations intermingled with lively discussions from the audience.
PMID: 19572816 [PubMed - as supplied by publisher]...
Source: Nanomedicine - June 30, 2009 Category: Nanotechnology Authors: Sharma HS, Sharma A Tags: Nanomed Source Type: journals
Conference Scene: Wake-up call for the engineering and biomedical science communities in nanomedicine.
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The IEEE-NIH 4th Life Science Systems and Applications Workshop 2009 (LiSSA '09) was jointly organized by the IEEE LiSSA Technical Committee and the NIH Nano Task Force. It was endorsed by the NIH Biomedical Information Science and Technology Initiative (BISTI) and the National Library of Medicine. The workshop was held in the Natcher Conference Center on the NIH campus in Bethesda, MD, USA. It took place on the 9-10 April, 2009, during the NIH NanoWeek and had approximately 200 delegates from around the globe (including North America, Europe, Asia and Australia) from both engineering and biomedical science disciplines...
Source: Nanomedicine - June 30, 2009 Category: Nanotechnology Authors: Beck D, Wong ST Tags: Nanomed Source Type: journals
Sustained antibacterial activity of doxycycline-loaded poly(D,L-lactide-co-glycolide) and poly(epsilon-caprolactone) nanoparticles.
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Aim: To increase the entrapment efficiency of doxycycline (DXY)-loaded poly(D,L-lactide-co-glycolide) (PLGA):poly(epsilon-caprolactone) (PCL) nanoparticles by up to 70% by varying the different formulation parameters such as polymer ratio, amount of drug loading (w/w), solvent selection, electrolyte addition and pH in the formulation. Method: Biodegradable polymers PLGA and PCL are used in various ratios for nanoparticle preparation using the water-in-oil-in-water double emulsion technique for water-soluble DXY. The physicochemical characterization of nanoparticles included size and surface charge measurement, study of...
Source: Nanomedicine - June 30, 2009 Category: Nanotechnology Authors: Misra R, Acharya S, Dilnawaz F, Sahoo SK Tags: Nanomed Source Type: journals
Multiwalled carbon nanotube buckypaper: toxicology and biological effects in vitro and in vivo.
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Conclusion: These results show a low toxicity of BP both in vitro and in vivo.
PMID: 19572819 [PubMed - as supplied by publisher] (Source: Nanomedicine)
Source: Nanomedicine - June 30, 2009 Category: Nanotechnology Authors: Bellucci S, Chiaretti M, Cucina A, Carru G, Chiaretti A Tags: Nanomed Source Type: journals
Neurodegenerative disorders and nanoformulated drug development.
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This article focuses on the pathobiology of common neurodegenerative disorders with a view towards how nanomedicine may be used to improve the clinical course of neurodegenerative disorders.
PMID: 19572820 [PubMed - as supplied by publisher] (Source: Nanomedicine)
Source: Nanomedicine - June 30, 2009 Category: Nanotechnology Authors: Nowacek A, Kosloski LM, Gendelman HE Tags: Nanomed Source Type: journals
NanoART, neuroAIDS and CNS drug delivery.
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This article focuses on how nanotechnology can serve to improve the delivery of antiretroviral medicines, termed nanoART, across the BBB and affect the biodistribution and clinical benefit for HIV-1 disease.
PMID: 19572821 [PubMed - as supplied by publisher] (Source: Nanomedicine)
Source: Nanomedicine - June 30, 2009 Category: Nanotechnology Authors: Nowacek A, Gendelman HE Tags: Nanomed Source Type: journals
Targeting cancer with 'smart bombs': equipping plant virus nanoparticles for a 'seek and destroy' mission.
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This article discusses plant virus nanoparticles as a weapon in the war on cancer. The successes and failures of numerous nanoparticle strategies are discussed as a background to consideration of the plant virus nanoparticle approach. To have therapeutic benefit, the advantages of the targeted nanoparticle must outweigh the problems of colloidal stability, uptake by the reticuloendothelial system as well as the requirement for clearance from the body. Biodegradable nanoparticles are considered to have the most promise to address these complex phenomena. After justifying the choice of biodegradable particles, the article fo...
Source: Nanomedicine - June 30, 2009 Category: Nanotechnology Authors: Franzen S, Lommel SA Tags: Nanomed Source Type: journals
Acknowledgements.
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PMID: 19572823 [PubMed - as supplied by publisher] (Source: Nanomedicine)
Source: Nanomedicine - June 30, 2009 Category: Nanotechnology Tags: Nanomed Source Type: journals
The photonic nanomedicine revolution: let the human side of nanotechnology emerge.
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PMID: 19505237 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - May 31, 2009 Category: Nanotechnology Authors: Halas NJ Tags: Nanomed Source Type: journals
Update on carbon nanotube toxicity.
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PMID: 19505238 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - May 31, 2009 Category: Nanotechnology Authors: Simeonova PP Tags: Nanomed Source Type: journals
Conference scene - nanotoxicology: health and environmental impacts.
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The conference on Nanotoxicology: Health & Environmental Impacts was organized by Euroscicon (Welwyn Garden City, UK), a team of professionals working towards the continuous improvement of technical knowledge transfer for all scientists, and hosted by 'BioPark', a research and development center in Welwyn Garden City, UK, on the 27th February 2009. The 1-day conference was chaired by SH Doak, Senior Lecturer and Research Councils UK Academic Fellow in Nanomedicine at Swansea University (Wales, UK) and brought together eminent scientists from seven different countries to interact and discuss the latest developments ...
Source: Nanomedicine - May 31, 2009 Category: Nanotechnology Authors: Singh N Tags: Nanomed Source Type: journals
Determining molecular mass distributions and compositions of functionalized dendrimer nanoparticles.
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This study demonstrates that a combination of unconventional electron microscopy techniques provides a quantitative means of assessing the degree of monodispersity of gadolinium (Gd) diethylenetriamine pentaacetic acid-conjugated polyamidoamine (PAMAM) dendrimers, which are designed for diagnostic imaging and delivering chemotherapeutics. Specifically, analysis of images acquired in the scanning transmission electron microscopy mode yields the distribution of molecular weights of individual dendrimers, whereas analysis of images acquired in the energy-filtering transmission electron microscopy mode yields the distribution ...
Source: Nanomedicine - May 31, 2009 Category: Nanotechnology Authors: Sousa AA, Aronova MA, Wu H, Sarin H, Griffiths GL, Leapman RD Tags: Nanomed Source Type: journals
Biodistribution of TNF-alpha-coated gold nanoparticles in an in vivo model system.
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CONCLUSION: These data suggest that CYT-6091 delivers TNF-alpha preferentially to the tumor and that upon TNF-alpha degradation, the liver takes up Au, which is cleared slowly over time.
PMID: 19505243 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - May 31, 2009 Category: Nanotechnology Authors: Goel R, Shah N, Visaria R, Paciotti GF, Bischof JC Tags: Nanomed Source Type: journals
Multicolor imaging of lymphatic function with two nanomaterials: quantum dot-labeled cancer cells and dendrimer-based optical agents.
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CONCLUSION: This technique could enable better understanding of lymph node metastasis.
PMID: 19505244 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - May 31, 2009 Category: Nanotechnology Authors: Kobayashi H, Ogawa M, Kosaka N, Choyke PL, Urano Y Tags: Nanomed Source Type: journals
Hyaluronan- and heparin-reduced silver nanoparticles with antimicrobial properties.
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CONCLUSION: These results suggest that DAPHP and HA silver nanoparticles have potential in antimicrobial therapeutic applications.
PMID: 19505245 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - May 31, 2009 Category: Nanotechnology Authors: Kemp MM, Kumar A, Clement D, Ajayan P, Mousa S, Linhardt RJ Tags: Nanomed Source Type: journals
Trastuzumab-functionalized nanoparticles of biodegradable copolymers for targeted delivery of docetaxel.
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CONCLUSION: Trastuzumab conjugated onto the NP surface has two functions: one is to target HER2-overexpressing cancer cells and the other is to enhance the cytotoxicity of docetaxel through synergistic effects. The trastuzumab-functionalized, docetaxel-loaded NPs have great potential for targeted chemotherapy to treat HER2-overexpressing cancer.
PMID: 19505246 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - May 31, 2009 Category: Nanotechnology Authors: Sun B, Feng SS Tags: Nanomed Source Type: journals
Nanoscale labels: nanoparticles and liposomes in the development of high-performance biosensors.
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Technology for the detection of biological species has generated considerable interest in a variety of fields including healthcare, defense, food and environmental monitoring. In a biosensor, labeled specific binding partners are used to emit a detectable signal. Owing to their unique properties, nanomaterials have been proposed as a novel label category and have led to the development of new assays and new transduction mechanisms. In this article, the role of three major types of nanoscale labels (metallic, semiconductor and liposome nanoparticles) in the development of a new generation of optical, electrochemical or ...
Source: Nanomedicine - May 31, 2009 Category: Nanotechnology Authors: Bally M, Vörös J Tags: Nanomed Source Type: journals
A never-ending love story with elastin: a scientific autobiography.
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The author describes, in a quite unconventional way, the most important results achieved in the last 50 years in the field of elastin structure-elasticity relationships, beginning with the first invaluable findings of Partridge on desmosines and isodesmosines until the most recent theories on elastomeric proteins. The author also relates a scientific autobiography characterized by his greatest passion, elastin.
PMID: 19505248 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - May 31, 2009 Category: Nanotechnology Authors: Tamburro AM Tags: Nanomed Source Type: journals
Microwave-assisted synthesis of PHEA-oligoamine copolymers as potential gene delivery systems.
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CONCLUSION: Results support the use of these copolymers as gene delivery systems in the future. Finally, the use of microwaves makes the proposed synthetic method advantageous as time and solvents are saved.
PMID: 19331530 [PubMed - in process] (Source: Nanomedicine)
Source: Nanomedicine - March 1, 2009 Category: Nanotechnology Authors: Cavallaro G, Licciardi M, Scirè S, Giammona G Tags: Nanomed Source Type: journals
