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Nature Biotechnology 27, 1058 (2009). doi:10.1038/nbt1109-1058 (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Tags: Careers and Recruitment Source Type: journals

A third quarter improvement for biotech hiringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 1056 (2009). doi:10.1038/nbt1109-1056 Author: Michael Francisco (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Michael Francisco Tags: Careers and Recruitment Source Type: journals

Research highlightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Craig Mak (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Laura De FrancescoMarkus ElsnerPeter HareCraig Mak Tags: Research Highlights Source Type: journals

Mapping duplicated sequencesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
arroll Duplicated genomic regions are accurately resolved using an optimized algorithm for mapping reads from next-generation sequencers. (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Derek Y ChiangSteven A McCarroll Tags: News and Views Source Type: journals

A systems view of host defenseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aderem Large-scale perturbations unravel the complex networks of activated dendritic cells. (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Daniel E ZakAlan Aderem Tags: News and Views Source Type: journals

Targeted sequencing with microfluidicsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 998 (2009). doi:10.1038/nbt1109-998 Author: Ewen F Kirkness Combining microdroplet PCR with flow-cell technologies provides a novel approach for sequencing thousands of genomic targets. (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Ewen F Kirkness Tags: News and Views Source Type: journals

Watching reprogramming in real timeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
elloch As a differentiated cell proceeds toward the pluripotent state, markers turn on and off in an orderly fashion. (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Deepa SubramanyamRobert Blelloch Tags: News and Views Source Type: journals

Recent patent applications in biological imagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 996 (2009). doi:10.1038/nbt1109-996 (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Tags: Feature Source Type: journals

The role of patents in biodiversity conservationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 994 (2009). doi:10.1038/nbt1109-994 Author: Charles Lawson Patents may not establish clear property and use rights and this may promote biodiversity destruction and decline. What is needed are schemes for patents to suit conservation and sustainable-use objectives. (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Charles Lawson Tags: Feature Source Type: journals

What's fueling the biotech engine—2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
What's fueling the biotech engine—2008 Nature Biotechnology 27, 987 (2009). doi:10.1038/nbt1109-987 Author: Saurabh Aggarwal Despite the global economic slowdown, biologics managed single-digit growth in 2008, driven mainly by continued high growth in sales of antibodies and insulins. Novel biologics in development look promising, but crowding, pricing and reimbursement are emerging as longer-term concerns. (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Saurabh Aggarwal Tags: Feature Source Type: journals

How Tysabri survivedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 986 (2009). doi:10.1038/nbt1109-986 Author: Brady Huggett Most drugs withdrawn from the market because of serious toxicities never make it back. But Biogen Idec succeeded in getting its multiple sclerosis (MS) drug Tysabri reintroduced in less than 16 months. (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Brady Huggett Tags: Commentary Source Type: journals

Accreditation and attribution in data sharingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 984 (2009). doi:10.1038/nbt1109-984b Author: Gudmundur A Thorisson (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Gudmundur A Thorisson Tags: Opinion and Comment Source Type: journals

The market value of GM productsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 984 (2009). doi:10.1038/nbt1109-984a Author: Rob Carlson (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Rob Carlson Tags: Opinion and Comment Source Type: journals

The gold rush for induced pluripotent stem cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 977 (2009). doi:10.1038/nbt1109-977 Author: Sarah Webb As the first commercial ventures are formed around induced pluripotent stem (iPS) cell research, who will have the freedom to operate commercially remains a big unknown. Sarah Webb reports. (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Sarah Webb Tags: News Source Type: journals

Whatever happened to GM wheat?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 974 (2009). doi:10.1038/nbt1109-974 Author: Jeffrey L Fox Agribusiness is taking another run at transgenic wheat after shelving its programs five years ago because of concerns from farmers, trade organizations and even state governments about market acceptance. Will there be a market this time? Jeffrey Fox investigates. (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Jeffrey L Fox Tags: News Source Type: journals

Biotech strikes back in Q3Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 973 (2009). doi:10.1038/nbt1109-973 Author: Walter Yang (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Walter Yang Tags: News Source Type: journals

Steve ReedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 971 (2009). doi:10.1038/nbt1109-971 Author: Charlotte Schubert Steve Reed believes the organization he has founded has the potential to radically increase the developing world's access to vaccines for neglected diseases. The efforts of the Seattle-based Infectious Disease Research Institute (IDRI), which operates as a not-for-profit biotech company, may start to pay off during the H1N1 'swine' flu pandemic. IDRI developed an adjuvant to boost the effectiveness and supplies of flu vaccines and is making the technology available to vaccine manufacturers in developing nations. Charlotte Schubert ta...
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Charlotte Schubert Tags: News Source Type: journals

Courts upbraid USDA for 'lax review' of GM cropsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 970 (2009). doi:10.1038/nbt1109-970c Author: Emily Waltz (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Emily Waltz Tags: News Source Type: journals

Kick-start for Canada's agbioEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 970 (2009). doi:10.1038/nbt1109-970b Author: John Hodgson (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: John Hodgson Tags: News Source Type: journals

Puerto Rico GM crop havenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 970 (2009). doi:10.1038/nbt1109-970a Author: Veronica Guerrero (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Veronica Guerrero Tags: News Source Type: journals

Genentech obtains proof of concept for hedgehog inhibitionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 968 (2009). doi:10.1038/nbt1109-968 Author: Cormac Sheridan (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Cormac Sheridan Tags: News Source Type: journals

'GMO-free' logosEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 967 (2009). doi:10.1038/nbt1109-967b Author: Emily Waltz (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Emily Waltz Tags: News Source Type: journals

One shot at H1N1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 967 (2009). doi:10.1038/nbt1109-967a Author: Wendy Wolfson (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Wendy Wolfson Tags: News Source Type: journals

Genzyme backs Osiris, despite Prochymal flopEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 966 (2009). doi:10.1038/nbt1109-966 Author: Malorye Allison (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Malorye Allison Tags: News Source Type: journals

First-to-market loses gripEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 964 (2009). doi:10.1038/nbt1109-964b Author: Bob Carlson (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Bob Carlson Tags: News Source Type: journals

Variant predicts HCV responseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 964 (2009). doi:10.1038/nbt1109-964a Author: Mike May (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Mike May Tags: News Source Type: journals

WHO guidelines presage US biosimilars legislation?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 963 (2009). doi:10.1038/nbt1109-963a Author: John Hodgson (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: John Hodgson Tags: News Source Type: journals

Surprise ruling eases diagnostic makers' fearsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 963 (2009). doi:10.1038/nbt1109-963b Author: Emily Waltz (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Emily Waltz Tags: News Source Type: journals

Pfizer settles largest ever fraud suit for off-label promotionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 961 (2009). doi:10.1038/nbt1109-961 Author: Mark Ratner (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Authors: Mark Ratner Tags: News Source Type: journals

Joining forcesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 959 (2009). doi:10.1038/nbt1109-959 Similar to outsourcing in the corporate world, technology incubators are beginning to look beyond their own borders to find technology. (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 7, 2009 Category: Biotechnology Tags: Editorial Source Type: journals

The challenges of sequencing by synthesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
z & Dmitri V Vezenov (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 6, 2009 Category: Biotechnology Authors: Carl W FullerLyle R MiddendorfSteven A BennerGeorge M ChurchTimothy HarrisXiaohua HuangStevan B JovanovichJohn R NelsonJeffery A SchlossDavid C SchwartzDmitri V Vezenov Tags: Research Source Type: journals

The transcription unit architecture of the Escherichia coli genomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ernhard Ø Palsson (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 1, 2009 Category: Biotechnology Authors: Byung-Kwan ChoKarsten ZenglerYu QiuYoung Seoub ParkEric M KnightChristian L BarrettYuan GaoBernhard Ø Palsson Tags: Research Source Type: journals

Microdroplet-based PCR enrichment for large-scale targeted sequencingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Darren R Link & Kelly A Frazer (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 1, 2009 Category: Biotechnology Authors: Ryan TewheyJason B WarnerMasakazu NakanoBrian LibbyMartina MedkovaPatricia H DavidSteve K KotsopoulosMichael L SamuelsJ Brian HutchisonJonathan W LarsonEric J TopolMichael P WeinerOlivier HarismendyJeff OlsonDarren R LinkKelly A Frazer Tags: Research Source Type: journals

An integrative approach to reveal driver gene fusions from paired-end sequencing data in cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
rt S Omenn & Arul M Chinnaiyan (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 1, 2009 Category: Biotechnology Authors: Xiao-Song WangJohn R PrensnerGuoan ChenQi CaoBo HanSaravana M DhanasekaranRakesh PonnalaXuhong CaoSooryanarayana VaramballyDafydd G ThomasThomas J GiordanoDavid G BeerNallasivam PalanisamyMaureen A SartorGilbert S OmennArul M Chinnaiyan Tags: Computational Biology Source Type: journals

Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical librariesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
oyd & Douglas S Auld (Source: Nature Biotechnology)
Source: Nature Biotechnology - October 25, 2009 Category: Biotechnology Authors: Henrike VeithNoel SouthallRuili HuangTim JamesDarren FayneNatalia ArtemenkoMin ShenJames IngleseChristopher P AustinDavid G LloydDouglas S Auld Tags: Research Source Type: journals

Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& Klaus Pechhold Analyzing specialized cells in heterogeneous tissues is crucial for understanding organ function in health and disease. Thus far, however, there has been no convenient method for studying gene expression in cells purified by fluorescence-activated cell sorting (FACS) using intracellular markers. Here we show that the quantitative nuclease protection assay (qNPA) enables transcriptional analysis of intracytoplasmically stained cells sorted by FACS. Applying the method to mouse pancreatic islet–cell subsets, we detected both expected and unknown lineage-specific gene expression patterns. Some beta ...
Source: Nature Biotechnology - October 18, 2009 Category: Biotechnology Authors: Susanne PechholdMelissa StoufferGregory WalkerRalph MartelBruce SeligmannYan HangRoland SteinDavid M HarlanKlaus Pechhold Tags: Research Source Type: journals

Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& Thorsten M Schlaeger Somatic cells can be reprogrammed into induced pluripotent stem (iPS) cells by enforced expression of transcription factors. Using serial live imaging of human fibroblasts undergoing reprogramming, we identified distinct colony types that morphologically resemble embryonic stem (ES) cells yet differ in molecular phenotype and differentiation potential. By analyzing expression of pluripotency markers, methylation at the OCT4 and NANOG promoters and differentiation into teratomas, we determined that only one colony type represents true iPS cells, whereas the others represent reprogramming intermedi...
Source: Nature Biotechnology - October 11, 2009 Category: Biotechnology Authors: Elayne M ChanSutheera RatanasirintrawootIn-Hyun ParkPhilip D ManosYuin-Han LohHongguang HuoJustine D MillerOdelya HartungJunsung RhoTan A InceGeorge Q DaleyThorsten M Schlaeger Tags: Research Source Type: journals

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Nature Biotechnology 27, 958 (2009). doi:10.1038/nbt1009-958 (Source: Nature Biotechnology)
Source: Nature Biotechnology - October 9, 2009 Category: Biotechnology Tags: Careers and Recruitment Source Type: journals

Erratum: Novo awaits green light for diabetes drugEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 957 (2009). doi:10.1038/nbt1009-957c Author: Mike May (Source: Nature Biotechnology)
Source: Nature Biotechnology - October 9, 2009 Category: Biotechnology Authors: Mike May Tags: Erratum Source Type: journals

Erratum: Diagnostics firms face new patent claim worriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 957 (2009). doi:10.1038/nbt1009-957b Author: Malorye Allison (Source: Nature Biotechnology)
Source: Nature Biotechnology - October 9, 2009 Category: Biotechnology Authors: Malorye Allison Tags: Erratum Source Type: journals

Erratum: Sanofi Aventis grooms its ranks for biotech partneringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 957 (2009). doi:10.1038/nbt1009-957a Author: Nuala Moran (Source: Nature Biotechnology)
Source: Nature Biotechnology - October 9, 2009 Category: Biotechnology Authors: Nuala Moran Tags: Erratum Source Type: journals

How to visually interpret biological data using networksEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
D Bader Networks in biology can appear complex and difficult to decipher. We illustrate how to interpret biological networks with the help of frequently used visualization and analysis patterns. (Source: Nature Biotechnology)
Source: Nature Biotechnology - October 9, 2009 Category: Biotechnology Authors: Daniele MericoDavid GfellerGary D Bader Tags: Computational Biology Source Type: journals

Research highlightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Craig Mak (Source: Nature Biotechnology)
Source: Nature Biotechnology - October 9, 2009 Category: Biotechnology Authors: Kathy AschheimMarkus ElsnerPeter HareCraig Mak Tags: Research Highlights Source Type: journals

Introducing the acetylomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
orkman Mass spectrometry reveals protein acetylation to be as widespread as phosphorylation. (Source: Nature Biotechnology)
Source: Nature Biotechnology - October 9, 2009 Category: Biotechnology Authors: Karen T SmithJerry L Workman Tags: News and Views Source Type: journals

Cancer's insatiable appetiteEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
r Heiden Seemingly unrelated mutations that drive cancer share the ability to promote nutrient uptake and metabolism conducive to cell growth. (Source: Nature Biotechnology)
Source: Nature Biotechnology - October 9, 2009 Category: Biotechnology Authors: Jason W LocasaleLewis C CantleyMatthew G Vander Heiden Tags: News and Views Source Type: journals

Stem cell biology meets p53Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Levine Often called “the guardian of the genome,” p53 may also be the guardian of stable development. (Source: Nature Biotechnology)
Source: Nature Biotechnology - October 9, 2009 Category: Biotechnology Authors: Anna M Puzio-KuterArnold J Levine Tags: News and Views Source Type: journals

Snapshots of kinase activitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
t J R Heck A mass spectrometry–based strategy facilitates sensitive and rapid detection of kinase activities in small amounts of cell lysate. (Source: Nature Biotechnology)
Source: Nature Biotechnology - October 9, 2009 Category: Biotechnology Authors: Javier MuñozAlbert J R Heck Tags: News and Views Source Type: journals

siRNA delivery not Toll-freeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
lliams Activating the tumor-associated immune system with an siRNA conjugated to a Toll-like receptor 9 ligand is a promising anticancer strategy. (Source: Nature Biotechnology)
Source: Nature Biotechnology - October 9, 2009 Category: Biotechnology Authors: Michael P GantierBryan R G Williams Tags: News and Views Source Type: journals

Recent patent applications in RNA interferenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Biotechnology 27, 910 (2009). doi:10.1038/nbt1009-910 (Source: Nature Biotechnology)
Source: Nature Biotechnology - October 9, 2009 Category: Biotechnology Tags: Feature Source Type: journals

Legal uncertainty in the area of genetic diagnostic testingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Overwalle A patent landscape analysis of 22 common genetic diagnostic tests shows substantially fewer claims on genes per se than initially suggested but raises questions of legal uncertainty as to the claims' scope. (Source: Nature Biotechnology)
Source: Nature Biotechnology - October 9, 2009 Category: Biotechnology Authors: Isabelle HuysNele BerthelsGert MatthijsGeertrui Van Overwalle Tags: Feature Source Type: journals