Nature Cell BiologyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest items in this publication.

Pages: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17

834 records returned

MyosinV controls PTEN function and neuronal cell sizeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Cell Biology 11, 1387 (2009). doi:10.1038/ncb1109-1387c Author: Michiel T. van Diepen, Maddy Parsons, C. Peter Downes, Nicholas R. Leslie, Robert Hindges & Britta J Eickholt (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 2, 2009 Category: Cytology Authors: Michiel T. van DiepenMaddy ParsonsC. Peter DownesNicholas R. LeslieRobert HindgesBritta J Eickholt Tags: Erratum Source Type: journals

Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Cell Biology 11, 1387 (2009). doi:10.1038/ncb1109-1387b Author: Fábio Klamt, Stéphanie Zdanov, Rodney L. Levine, Ashley Pariser, Yaqin Zhang, Baolin Zhang, Li-Rong Yu, Timothy D. Veenstra & Emily Shacter (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 2, 2009 Category: Cytology Authors: Fábio KlamtStéphanie ZdanovRodney L. LevineAshley PariserYaqin ZhangBaolin ZhangLi-Rong YuTimothy D. VeenstraEmily Shacter Tags: Corrigendum Source Type: journals

Functional interaction between FOXO3a and ATM regulates DNA damage responseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Cell Biology 11, 1387 (2009). doi:10.1038/ncb1109-1387a Author: Wen-Bin Tsai, Young Min Chung, Yoko Takahashi, Zhaohui Xu & Mickey C-T. Hu (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 2, 2009 Category: Cytology Authors: Wen-Bin TsaiYoung Min ChungYoko TakahashiZhaohui XuMickey C-T. Hu Tags: Corrigendum Source Type: journals

Research highlightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Cell Biology 11, 1285 (2009). doi:10.1038/ncb1109-1285 Author: Nathalie Le Bot, Silvia Grisendi, Christina Karlsson Rosenthal & Sowmya Swaminathan (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 2, 2009 Category: Cytology Authors: Nathalie Le BotSilvia GrisendiChristina Karlsson RosenthalSowmya Swaminathan Tags: Research Highlights Source Type: journals

Tip60-ing the balance in DSB repairEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Cell Biology 11, 1279 (2009). doi:10.1038/ncb1109-1279 Author: Wolfgang Fischle The tumour suppressor Tip60 is a histone acetyltransferase implicated in transcriptional control and DNA double-strand break repair. Tip60 binds to the heterochromatic histone mark H3K9me3, triggering acetylation and activation of DNA double-strand break repair factors. (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 2, 2009 Category: Cytology Authors: Wolfgang Fischle Tags: News and Views Source Type: journals

Spermidine surprise for a long lifeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Cell Biology 11, 1277 (2009). doi:10.1038/ncb1109-1277 Author: Matt Kaeberlein Identifying therapies to slow down ageing and delay age-associated diseases is a primary goal of ageing-related research. Resveratrol and rapamycin were first found to promote longevity in yeast, and their effects were then extended to several organisms. Spermidine is a new longevity drug that can increase life span in yeast, nematodes and flies, possibly through an effect on chromatin-mediated regulation of gene expression. (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 2, 2009 Category: Cytology Authors: Matt Kaeberlein Tags: News and Views Source Type: journals

Cyclin-dependent kinases: a family portraitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
; Debra J. Wolgemuth (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 2, 2009 Category: Cytology Authors: Marcos MalumbresEdward HarlowTim HuntTony HunterJill M. LahtiGerard ManningDavid O. MorganLi-Huei TsaiDebra J. Wolgemuth Tags: Correspondence Source Type: journals

Change is good: life outside the nucleusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Cell Biology 11, 1274 (2009). doi:10.1038/ncb1109-1274 Author: Randy Schekman (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 2, 2009 Category: Cytology Authors: Randy Schekman Tags: Turning Points Source Type: journals

Funding pain in SpainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Cell Biology 11, 1273 (2009). doi:10.1038/ncb1109-1273b On the eve of budget decisions, the scale of cuts to basic research funding remains ill-defined. (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 2, 2009 Category: Cytology Tags: Editorial Source Type: journals

Sharing dataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Cell Biology 11, 1273 (2009). doi:10.1038/ncb1109-1273a Reference datasets should be accessible independently of scientific papers in a citable form, allowing attribution. (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 2, 2009 Category: Cytology Tags: Editorial Source Type: journals

Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cosima T. Baldari Most eukaryotic cells have a primary cilium which functions as a sensory organelle. Cilia are assembled by intraflagellar transport (IFT), a process mediated by multimeric IFT particles and molecular motors. Here we show that lymphoid and myeloid cells, which lack primary cilia, express IFT proteins. IFT20, an IFT component essential for ciliary assembly, was found to colocalize with both the microtubule organizing centre (MTOC) and Golgi and post-Golgi compartments in T-lymphocytes. In antigen-specific conjugates, IFT20 translocated to the immune synapse. IFT20 knockdown resulted in impaired T-cell rece...
Source: Nature Cell Biology - October 25, 2009 Category: Cytology Authors: Francesca FinettiSilvia Rossi PaccaniMaria Giovanna RiparbelliEmiliana GiacomelloGiuseppe PerinettiGregory J. PazourJoel L. RosenbaumCosima T. Baldari Tags: Letter Source Type: journals

DNA damage signalling prevents deleterious telomere addition at DNA breaksEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ckburn (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 18, 2009 Category: Cytology Authors: Svetlana MakovetsElizabeth H. Blackburn Tags: Brief Communication Source Type: journals

FLIP-mediated autophagy regulation in cell death controlEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Liang & Jae U. Jung Autophagy is an active homeostatic degradation process for the removal or turnover of cytoplasmic components wherein the LC3 ubiquitin-like protein undergoes an Atg7 E1-like enzyme/Atg3 E2-like enzyme-mediated conjugation process to induce autophagosome biogenesis. Besides its cytoprotecive role, autophagy acts on cell death when it is abnormally upregulated. Thus, the autophagy pathway requires tight regulation to ensure that this degradative process is well balanced. Two death effector domains (DED1/2) containing cellular FLICE-like inhibitor protein (cFLIP) and viral FLIP (vFLIP) of Kaposi's sar...
Source: Nature Cell Biology - October 18, 2009 Category: Cytology Authors: Jong-Soo LeeQinglin LiJune-Yong LeeSun-Hwa LeeJoseph H. JeongHye-Ra LeeHeesoon ChangFu-Chun ZhouShou-Jiang GaoChengyu LiangJae U. Jung Tags: Letter Source Type: journals

Analysis of the γ-secretase interactome and validation of its association with tetraspanin-enriched microdomainsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Analysis of the γ-secretase interactome and validation of its association with tetraspanin-enriched microdomains Nature Cell Biology 11, 1340 (2009). doi:10.1038/ncb1978 Authors: Tomoko Wakabayashi, Katleen Craessaerts, Leen Bammens, Mostafa Bentahir, Filip Borgions, Piet Herdewijn, An Staes, Evy Timmerman, Joël Vandekerckhove, Eric Rubinstein, Claude Boucheix, Kris Gevaert & Bart De Strooper γ-Secretase, an aspartyl protease that belongs to the iCLiPs (intramembrane cleaving proteases) family, is a multiprotein complex that consists of presenilin (PS), nicastrin (NCT), Aph-1 and Pen-2 (ref. 1). It is ...
Source: Nature Cell Biology - October 18, 2009 Category: Cytology Authors: Tomoko WakabayashiKatleen CraessaertsLeen BammensMostafa BentahirFilip BorgionsPiet HerdewijnAn StaesEvy TimmermanJoël VandekerckhoveEric RubinsteinClaude BoucheixKris GevaertBart De Strooper Tags: Letter Source Type: journals

Slit2–Robo4 signalling promotes vascular stability by blocking Arf6 activityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we used cell biological and biochemical techniques to elucidate the molecular mechanism underlying the maintenance of vascular stability by Robo4. Here, we demonstrate that Robo4 mediates Slit2-dependent suppression of cellular protrusive activity through direct interaction with the intracellular adaptor protein paxillin and its paralogue, Hic-5. Formation of a Robo4–paxillin complex at the cell surface blocks activation of the small GTPase Arf6 and, consequently, Rac by recruitment of Arf-GAPs (ADP-ribosylation factor- directed GTPase-activating proteins) such as GIT1. Consistent with these in vitro s...
Source: Nature Cell Biology - October 18, 2009 Category: Cytology Authors: Christopher A. JonesNaoyuki NishiyaNyall R. LondonWeiquan ZhuLise K. SorensenAubrey C. ChanChinten J. LimHaoyu ChenQisheng ZhangPeter G. SchultzAlaa M. HayallahKirk R. ThomasMichael FamulokKang ZhangMark H. GinsbergDean Y. Li Tags: Letter Source Type: journals

Topoisomerase I suppresses genomic instability by preventing interference between replication and transcriptionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Jamal Tazi, Arnaud Coquelle & Philippe Pasero (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 18, 2009 Category: Cytology Authors: Sandie TuduriLaure CrabbéChiara ContiHélène TourrièreHeidi Holtgreve-GrezAnna JauchVéronique PantescoJohn De VosAubin ThomasCharles TheilletYves PommierJamal TaziArnaud CoquellePhilippe Pasero Tags: Article Source Type: journals

Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility Nature Cell Biology 11, 1287 (2009). doi:10.1038/ncb1973 Authors: Silvia Giampieri, Cerys Manning, Steven Hooper, Louise Jones, Caroline S. Hill & Erik Sahai (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 18, 2009 Category: Cytology Authors: Silvia GiampieriCerys ManningSteven HooperLouise JonesCaroline S. HillErik Sahai Tags: Article Source Type: journals

TGF-β helps cells fly soloEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
TGF-β helps cells fly solo Nature Cell Biology 11, 1281 (2009). doi:10.1038/ncb1109-1281 Authors: Lauren A. Matise, Michael W. Pickup & Harold L. Moses Intravital imaging demonstrates that TGF-β signalling regulates the mode of cancer cell motility. Cells with active TGF-β signalling migrate as single cells and are capable of hematogenous and lymphatic spread, whereas cells lacking TGF-β signalling invade lymphatics collectively. (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 18, 2009 Category: Cytology Authors: Lauren A. MatiseMichael W. PickupHarold L. Moses Tags: News and Views Source Type: journals

UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ashok R. Venkitaraman The anaphase-promoting complex (APC/C), a ubiquitin ligase, is the target of the spindle-assembly checkpoint (SAC), and it ubiquitylates protein substrates whose degradation regulates progress through mitosis. The identity of the ubiquitin-conjugating (E2) enzymes that work with the APC/C is unclear. In an RNA interference (RNAi) screen for factors that modify release from drug-induced SAC activation, we identified the E2 enzyme UBE2S as an APC/C auxiliary factor that promotes mitotic exit. UBE2S is dispensable in a normal mitosis, but its depletion prolongs drug-induced mitotic arrest and suppresses...
Source: Nature Cell Biology - October 11, 2009 Category: Cytology Authors: Mathew J. GarnettJörg MansfeldColin GodwinTakahiro MatsusakaJiahua WuPaul RussellJonathon PinesAshok R. Venkitaraman Tags: Letter Source Type: journals

Tudor staphylococcal nuclease is an evolutionarily conserved component of the programmed cell death degradomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
vialov, Ulf Ståhl, Patrick J. Hussey, Olli Silvennoinen, Eva Sundberg, Boris Zhivotovsky & Peter V. Bozhkov Programmed cell death (PCD) is executed by proteases, which cleave diverse proteins thus modulating their biochemical and cellular functions. Proteases of the caspase family and hundreds of caspase substrates constitute a major part of the PCD degradome in animals. Plants lack close homologues of caspases, but instead possess an ancestral family of cysteine proteases, metacaspases. Although metacaspases are essential for PCD, their natural substrates remain unknown. Here we show that metacaspase mcII-Pa clea...
Source: Nature Cell Biology - October 11, 2009 Category: Cytology Authors: Jens F. SundströmAlena VaculovaAndrei P. SmertenkoEugene I. SavenkovAnna GolovkoElena MininaBudhi S. TiwariSalvador Rodriguez-NietoAndrey A. ZamyatninTuuli VälinevaJuha SaarikettuMikko J. FrilanderMaria F. SuarezAnton ZavialovUlf StåhlPatrick J. Hussey Tags: Letter Source Type: journals

Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study reveals a ubiquitin ligase-independent function of parkin in the control of transcription and a functional link between parkin and p53 that is altered by AR-JP mutations. (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 4, 2009 Category: Cytology Authors: Cristine Alves da CostaClaire SunyachEmilie GiaimeAndrew WestOlga CortiAlexis BriceStephen SafePatrick M. Abou-SleimanNicholas W. WoodHitoshi TakahashiMathew S. GoldbergJie ShenFrédéric Checler Tags: Letter Source Type: journals

Induction of autophagy by spermidine promotes longevityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
riollo, Evgenia Megalou, Daniela Weiskopf, Peter Laun, Gino Heeren, Michael Breitenbach, Beatrix Grubeck-Loebenstein, Eva Herker, Birthe Fahrenkrog, Kai-Uwe Fröhlich, Frank Sinner, Nektarios Tavernarakis, Nadege Minois, Guido Kroemer & Frank Madeo (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 4, 2009 Category: Cytology Authors: Tobias EisenbergHeide KnauerAlexandra SchauerSabrina BüttnerChristoph RuckenstuhlDidac Carmona-GutierrezJulia RingSabrina SchroederChristoph MagnesLucia AntonacciHeike FussiLuiza DeszczRegina HartlElisabeth SchramlAlfredo CriolloEvgenia MegalouDaniela We Tags: Article Source Type: journals

KLF17 is a negative regulator of epithelial–mesenchymal transition and metastasis in breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
KLF17 is a negative regulator of epithelial–mesenchymal transition and metastasis in breast cancer Nature Cell Biology 11, 1297 (2009). doi:10.1038/ncb1974 Authors: Kiranmai Gumireddy, Anping Li, Phyllis A. Gimotty, Andres J. Klein-Szanto, Louise C. Showe, Dionyssios Katsaros, George Coukos, Lin Zhang & Qihong Huang (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 4, 2009 Category: Cytology Authors: Kiranmai GumireddyAnping LiPhyllis A. GimottyAndres J. Klein-SzantoLouise C. ShoweDionyssios KatsarosGeorge CoukosLin ZhangQihong Huang Tags: Article Source Type: journals

mRNA decay turns on apoptosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Cell Biology 11, 1272 (2009). doi:10.1038/ncb1009-1272d (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 1, 2009 Category: Cytology Tags: Corrigendum Source Type: journals

Axin determines cell fate by controlling the p53 activation threshold after DNA damageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Cell Biology 11, 1272 (2009). doi:10.1038/ncb1009-1272c Author: Qinxi Li, Shuyong Lin, Xuan Wang, Guili Lian, Zailian Lu, Huiling Guo, Ka Ruan, Yanhai Wang, Zhiyun Ye, Jiahuai Han & Sheng-Cai Lin (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 1, 2009 Category: Cytology Authors: Qinxi LiShuyong LinXuan WangGuili LianZailian LuHuiling GuoKa RuanYanhai WangZhiyun YeJiahuai HanSheng-Cai Lin Tags: Corrigendum Source Type: journals

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Cell Biology 11, 1272 (2009). doi:10.1038/ncb1009-1272b Author: Derrick J. Gibbings, Constance Ciaudo, Mathieu Erhardt & Olivier Voinnet (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 1, 2009 Category: Cytology Authors: Derrick J. GibbingsConstance CiaudoMathieu ErhardtOlivier Voinnet Tags: Erratum Source Type: journals

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Cell Biology 11, 1272 (2009). doi:10.1038/ncb1009-1272a Author: Francis Rodier, Jean-Philippe Coppé, Christopher K. Patil, Wieteke A. M. Hoeijmakers, Denise P. Muñoz, Saba R. Raza, Adam Freund, Eric Campeau, Albert R. Davalos & Judith Campisi (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 1, 2009 Category: Cytology Authors: Francis RodierJean-Philippe CoppéChristopher K. PatilWieteke A. M. HoeijmakersDenise P. MuñozSaba R. RazaAdam FreundEric CampeauAlbert R. DavalosJudith Campisi Tags: Erratum Source Type: journals

Research highlightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Cell Biology 11, 1180 (2009). doi:10.1038/ncb1009-1180 Author: Bernd Pulverer, Christina Karlsson Rosenthal, Alison Schuldt & Sowmya Swaminathan (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 1, 2009 Category: Cytology Authors: Bernd PulvererChristina Karlsson RosenthalAlison SchuldtSowmya Swaminathan Tags: Research Highlights Source Type: journals

A motor driving PTENEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Parada To fulfil its lipid phosphatase function, PTEN must be in close proximity to the plasma membrane where its substrates reside. PTEN translocation to the plasma membrane is an active process that is mediated by the myosin-based transport machinery. MyosinV controls PTEN membrane association and thus, PTEN-mediated cell growth in neurons. (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 1, 2009 Category: Cytology Authors: Jing ZhouLuis F. Parada Tags: News and Views Source Type: journals

NURD keeps chromatin youngEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
enbaum Progerin, a mutated form of lamin A, causes the premature ageing disease Hutchinson-Gilford progeria syndrome and is also involved in normal ageing. Progerin accumulation leads to distinct chromatin-related defects and the NURD complex appears to affect ageing-related chromatin defects. (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 1, 2009 Category: Cytology Authors: Eran MeshorerYosef Gruenbaum Tags: News and Views Source Type: journals

A bacterial virulence factor that dissipates tensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Van Nhieu Various microbes harness the actin polymerization machinery through their surface proteins to allow intracellular motility within host cells, but other virulence factors regulate dissemination. The cortical actin tension of polarized cells may represent a physical barrier that hinders the formation of microbial protrusions during cell-to-cell spreading. (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 1, 2009 Category: Cytology Authors: Stéphane RomeroGuy Tran Van Nhieu Tags: News and Views Source Type: journals

Receptor-like kinases shape the plantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& Tom Beeckman (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 1, 2009 Category: Cytology Authors: Ive De SmetUte VoßGerd JürgensTom Beeckman Tags: Review Source Type: journals

Milestones in light microscopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Cell Biology 11, 1165 (2009). doi:10.1038/ncb1009-1165 A supplement contextualizes key advances in light microscopy over 400 years, while the Tara expedition sets sail to explore oceanic ecosystems at the microscopic level. (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 1, 2009 Category: Cytology Tags: Editorial Source Type: journals

Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Brendan D. Price DNA double-strand break (DSB) repair involves complex interactions between chromatin and repair proteins, including Tip60, a tumour suppressor. Tip60 is an acetyltransferase that acetylates both histones and ATM (ataxia telangiectasia mutated) kinase. Inactivation of Tip60 leads to defective DNA repair and increased cancer risk. However, how DNA damage activates the acetyltransferase activity of Tip60 is not known. Here, we show that direct interaction between the chromodomain of Tip60 and histone H3 trimethylated on lysine 9 (H3K9me3) at DSBs activates the acetyltransferase activity of Tip60. Depletion of...
Source: Nature Cell Biology - September 27, 2009 Category: Cytology Authors: Yingli SunXiaofeng JiangYe XuMarina K. AyrapetovLisa A. MoreauJohnathan R. WhetstineBrendan D. Price Tags: Letter Source Type: journals

Identification of chromosome sequence motifs that mediate meiotic pairing and synapsis in C. elegansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Cell Biology 11, 1163 (2009). doi:10.1038/ncb0909-1163 Author: Carolyn M. Phillips, Xiangdong Meng, Lei Zhang, Jacqueline H. Chretien, Fyodor D. Urnov & Abby F. Dernburg (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 22, 2009 Category: Cytology Authors: Carolyn M. PhillipsXiangdong MengLei ZhangJacqueline H. ChretienFyodor D. UrnovAbby F. Dernburg Tags: Erratum Source Type: journals

Research highlightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Cell Biology 11, 1055 (2009). doi:10.1038/ncb0909-1055 Author: Silvia Grisendi, Nathalie Le Bot, Alison Schuldt & Sowmya Swaminathan (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 22, 2009 Category: Cytology Authors: Silvia GrisendiNathalie Le BotAlison SchuldtSowmya Swaminathan Tags: Research Highlights Source Type: journals

Aurora A moonlights in neurite extensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
leeson Aurora A, an integral mitotic kinase, is essential for microtubule dynamics of post-mitotic neurons. PKCζ activates Aurora A, which in turn phosphorylates NDEL1 to promote neurite extension. This raises the possibility that Aurora A may also be involved in establishing cell polarity and axon/dendrite elaboration in young neurons. (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 22, 2009 Category: Cytology Authors: Gloria Kuo LefkowitzJoseph G. Gleeson Tags: News and Views Source Type: journals

Steroid hormone pulsing drives cyclic gene expressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
e Héligon Transcriptional cycling of activated glucocorticoid receptor (GR) and ultradian glucocorticoid secretion are well established processes. Ultradian hormone release is now shown to result in pulsatile gene transcription through dynamic exchange of GR with the target-gene promoter and GR cycling through the chaperone machinery. (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 22, 2009 Category: Cytology Authors: Béatrice DesvergneChristophe Héligon Tags: News and Views Source Type: journals

RISC hitches onto endosome traffickingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Siomi The RNA-induced silencing complex (RISC) downregulates expression of the genes targeted by RNA-silencing pathways. But formation and turnover of the RISC complex itself is tightly regulated and requires endosomal membranes. (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 22, 2009 Category: Cytology Authors: Haruhiko SiomiMikiko C Siomi Tags: News and Views Source Type: journals

SAD kinase keeps centrosomes lonelyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vogel Centrosome duplication is under strict control such that it occurs only once per cell cycle. New insights into the molecular mechanisms that control centrosome number come from the discovery of a role for SADB kinase in centrosome biogenesis. (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 22, 2009 Category: Cytology Authors: Daici ChenJackie Vogel Tags: News and Views Source Type: journals

Ambition, surprise and delight: necessary lessonsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Cell Biology 11, 1046 (2009). doi:10.1038/ncb0909-1046 Author: Henry R. Bourne (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 22, 2009 Category: Cytology Authors: Henry R. Bourne Tags: Turning Points Source Type: journals

Accurately reporting researchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Cell Biology 11, 1045 (2009). doi:10.1038/ncb0909-1045 The cell biology literature contains manipulated data that distort findings, usually in an attempt to 'beautify' and, rarely, to commit fraud. A new National Academy of Sciences (NAS) report considers data integrity, as well as accessibility and archiving. However, the scientific record can also be distorted through miscitation. (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 22, 2009 Category: Cytology Tags: Editorial Source Type: journals

The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic developmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report here that Fuz mutant mice show neural tube defects, skeletal dysmorphologies and Hedgehog signalling defects stemming from disrupted ciliogenesis. Using bioinformatics and imaging of an in vivo mucociliary epithelium, we established a central role for Fuz in membrane trafficking, showing that Fuz is essential for trafficking of cargo to basal bodies and to the apical tips of cilia. Fuz is also essential for exocytosis in secretory cells. Finally, we identified a Rab-related small GTPase as a Fuz interaction partner that is also essential for ciliogenesis and secretion. These results are significant because they p...
Source: Nature Cell Biology - September 19, 2009 Category: Cytology Authors: Ryan S. GrayPhilip B. AbituaBogdan J. WlodarczykHeather L. Szabo-RogersOtis BlanchardInsuk LeeGreg S. WeissKaren J. LiuEdward M. MarcotteJohn B. WallingfordRichard H. Finnell Tags: Letter Source Type: journals

Intracellular fluid flow in rapidly moving cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a physical model for fluid pressure and flow in moving cells that quantitatively accounts for our experimental data. (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 19, 2009 Category: Cytology Authors: Kinneret KerenPatricia T. YamAnika KinkhabwalaAlex MogilnerJulie A. Theriot Tags: Letter Source Type: journals

The bacterial virulence factor InlC perturbs apical cell junctions and promotes cell-to-cell spread of ListeriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
n & Keith Ireton Several pathogenic bacteria, including Listeria monocytogenes, use an F-actin motility process to spread between mammalian cells. Actin 'comet tails' propel Listeria through the cytoplasm, resulting in bacteria-containing membrane protrusions that are internalized by neighbouring cells. The mechanism by which Listeria overcomes cortical tension to generate protrusions is unknown. Here, we identify bacterial and host proteins that directly regulate protrusions. We show that efficient spreading between polarized epithelial cells requires the secreted Listeria virulence protein InlC (internalin C). We nex...
Source: Nature Cell Biology - September 19, 2009 Category: Cytology Authors: Tina RajabianBalramakrishna GavicherlaMartin HeisigStefanie Müller-AltrockWerner GoebelScott D. Gray-OwenKeith Ireton Tags: Letter Source Type: journals

Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
egawa, Masahito Ikawa, Masaru Okabe, Akio Wanaka & Kazunori Imaizumi Eukaryotic cells have signalling pathways from the endoplasmic reticulum (ER) to cytosol and nuclei, to avoid excess accumulation of unfolded proteins in the ER. We previously identified a new type of ER stress transducer, OASIS, a bZIP (basic leucine zipper) transcription factor, which is a member of the CREB/ATF family and has a transmembrane domain. OASIS is processed by regulated intramembrane proteolysis (RIP) in response to ER stress, and is highly expressed in osteoblasts. OASIS−/− mice exhibited severe osteopenia, involving a decre...
Source: Nature Cell Biology - September 19, 2009 Category: Cytology Authors: Tomohiko MurakamiAtsushi SaitoShin-ichiro HinoShinichi KondoSoshi KanemotoKazuyasu ChiharaHiroshi SekiyaKenji TsumagariKimiko OchiaiKazuya YoshinagaMasahiro SaitohRiko NishimuraToshiyuki YonedaIkuyo KouTatsuya FuruichiShiro IkegawaMasahito IkawaMasaru Oka Tags: Letter Source Type: journals

Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we generated Bbf2h7−/− mice to assess the in vivo function of BBF2H7. The mice showed severe chondrodysplasia and died by suffocation shortly after birth because of an immature chest cavity. The cartilage showed a lack of typical columnar structure in the proliferating zone and a decrease in the size of the hypertrophic zone, resulting in a significant reduction of extracellular matrix proteins. Interestingly, proliferating chondrocytes showed abnormally expanded ER, containing aggregated type II collagen (Col2) and cartilage oligomeric matrix protein (COMP). We identified Sec23a, which encodes a...
Source: Nature Cell Biology - September 19, 2009 Category: Cytology Authors: Atsushi SaitoShin-ichiro HinoTomohiko MurakamiSoshi KanemotoShinichi KondoMasahiro SaitohRiko NishimuraToshiyuki YonedaTatsuya FuruichiShiro IkegawaMasahito IkawaMasaru OkabeKazunori Imaizumi Tags: Letter Source Type: journals

MyosinV controls PTEN function and neuronal cell sizeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
tta J Eickholt The tumour suppressor PTEN can inhibit cell proliferation and migration as well as control cell growth, in different cell types. PTEN functions predominately as a lipid phosphatase, converting PtdIns(3,4,5)P3 to PtdIns(4,5)P2, thereby antagonizing PI(3)K (phosphoinositide 3-kinase) and its established downstream effector pathways. However, much is unclear concerning the mechanisms that regulate PTEN movement to the cell membrane, which is necessary for its activity towards PtdIns(3,4,5)P3 (Refs 3, 4, 5). Here we show a requirement for functional motor proteins in the control of PI3K signalling, involving a p...
Source: Nature Cell Biology - September 19, 2009 Category: Cytology Authors: Michiel T. van DiepenMaddy ParsonsC. Peter DownesNicholas R. LeslieRobert HindgesBritta J Eickholt Tags: Letter Source Type: journals

The non-coding RNA of the multidrug resistance-linked vault particle encodes multiple regulatory small RNAsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
amp; Carlos Rovira (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 12, 2009 Category: Cytology Authors: Helena PerssonAnders KvistJohan Vallon-ChristerssonPatrik MedstrandÅke BorgCarlos Rovira Tags: Brief Communication Source Type: journals

Listeria monocytogenes ActA-mediated escape from autophagic recognitionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
raborty & Chihiro Sasakawa Autophagy degrades unnecessary organelles and misfolded protein aggregates, as well as cytoplasm-invading bacteria. Nevertheless, the bacteria Listeria monocytogenes efficiently escapes autophagy. We show here that recruitment of the Arp2/3 complex and Ena/VASP, via the bacterial ActA protein, to the bacterial surface disguises the bacteria from autophagic recognition, an activity that is independent of the ability to mediate bacterial motility. L. monocytogenes expressing ActA mutants that lack the ability to recruit the host proteins initially underwent ubiquitylation, followed by recruitme...
Source: Nature Cell Biology - September 12, 2009 Category: Cytology Authors: Yuko YoshikawaMichinaga OgawaTorsten HainMitsutaka YoshidaMakoto FukumatsuMinsoo KimHitomi MimuroIchiro NakagawaToru YanagawaTetsuro IshiiAkira KakizukaElizabeth SztulTrinad ChakrabortyChihiro Sasakawa Tags: Letter Source Type: journals