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Erratum: The role of dynamic conformational ensembles in biomolecular recognitionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, 954 (2009). doi:10.1038/nchembio1209-954d Author: David D Boehr, Ruth Nussinov & Peter E Wright (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - November 14, 2009 Category: Biology Authors: David D BoehrRuth NussinovPeter E Wright Tags: Erratum Source Type: journals

Erratum: Targeting proteins for degradationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, 954 (2009). doi:10.1038/nchembio1209-954c Author: Erin K Schrader, Kristine G Harstad & Andreas Matouschek (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - November 14, 2009 Category: Biology Authors: Erin K SchraderKristine G HarstadAndreas Matouschek Tags: Erratum Source Type: journals

Erratum: S1P1 signaling just keeps going and going and going...Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, 954 (2009). doi:10.1038/nchembio1209-954b Author: Stuart Cahalan & Hugh Rosen (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - November 14, 2009 Category: Biology Authors: Stuart CahalanHugh Rosen Tags: Erratum Source Type: journals

Corrigendum: Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, 954 (2009). doi:10.1038/nchembio1209-954a Author: Florian Mullershausen, Frédéric Zecri, Cihan Cetin, Andreas Billich, Danilo Guerini & Klaus Seuwen (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - November 14, 2009 Category: Biology Authors: Florian MullershausenFrédéric ZecriCihan CetinAndreas BillichDanilo GueriniKlaus Seuwen Tags: Corrigendum Source Type: journals

Research highlightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, 876 (2009). doi:10.1038/nchembio.270 (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - November 14, 2009 Category: Biology Tags: News and Views Source Type: journals

On the mechanism of iron sensing by IRP2: new players, new paradigmsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
y Kaplan Two iron regulatory proteins (IRP1 and IRP2) regulate translation and/or stability of mRNAs encoding proteins required for iron storage, acquisition and utilization. Rather than IRP2 directly sensing iron concentrations, iron has been shown to regulate the level of the SKP1-CUL1-FBXL5 E3 ubiquitin ligase protein complex, which is responsible for IRP2 degradation. (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - November 14, 2009 Category: Biology Authors: Naoko Takahashi-MakiseDiane McVey WardJerry Kaplan Tags: News and Views Source Type: journals

PKR and the ribosome compete for mRNAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
lacqua The RNA-activated protein kinase PKR inhibits translation initiation by sensing long viral double-stranded RNA. A new report indicates that PKR is also activated by a cellular mRNA, but only when ribosomes are not initiating translation. (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - November 14, 2009 Category: Biology Authors: Rebecca ToroneyPhilip C Bevilacqua Tags: News and Views Source Type: journals

Genomic variations on a CoA biosynthetic themeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, 871 (2009). doi:10.1038/nchembio.267 Author: Andrei L Osterman A unique heterotrimeric assembly of individually inactive paralogs, two of which are also involved in regulating phosphatase activity, creates one of the key enzymes of coenzyme A biosynthesis in yeast, pointing to the possibility of a previously undescribed cross-talk between metabolic and signaling pathways. (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - November 14, 2009 Category: Biology Authors: Andrei L Osterman Tags: News and Views Source Type: journals

Deciphering bacterial languageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, 870 (2009). doi:10.1038/nchembio.263 Author: Vanessa Sperandio Vibrio cholerae produces cholera autoinducer-1 (CAI-1), a signaling molecule previously believed to be synthesized by the CqsA enzyme. Here it is shown that CqsA does not directly synthesize CAI-1; instead, it synthesizes amino-CAI-1, which is then converted into CAI-1 in a CqsA-independent manner. (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - November 14, 2009 Category: Biology Authors: Vanessa Sperandio Tags: News and Views Source Type: journals

Nitrate and nitrite in biology, nutrition and therapeuticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
hapiro, Andrey V Kozlov, Jack R Lancaster, David J Lefer, Kenneth McColl, Kenneth McCurry, Rakesh P Patel, Joel Petersson, Tienush Rassaf, Valentin P Reutov, George B Richter-Addo, Alan Schechter, Sruti Shiva, Koichiro Tsuchiya, Ernst E van Faassen, Andrew J Webb, Brian S Zuckerbraun, Jay L Zweier & Eddie Weitzberg Inorganic nitrate and nitrite from endogenous or dietary sources are metabolized in vivo to nitric oxide (NO) and other bioactive nitrogen oxides. The nitrate-nitrite-NO pathway is emerging as an important mediator of blood flow regulation, cell signaling, energetics and tissue responses to hypoxia. The late...
Source: Nature Chemical Biology - November 14, 2009 Category: Biology Authors: Jon O LundbergMark T GladwinAmrita AhluwaliaNigel BenjaminNathan S BryanAnthony ButlerPedro CabralesAngela FagoMartin FeelischPeter C FordBruce A FreemanMichael FrenneauxJoel FriedmanMalte KelmChristopher G KevilDaniel B Kim-ShapiroAndrey V KozlovJack R L Tags: Meeting Report Source Type: journals

Come togetherEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, 863 (2009). doi:10.1038/nchembio.272 The third Nature Chemical Biology symposium brought together nearly 200 scientists to explore the frontiers of chemical biology and drug discovery. (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - November 14, 2009 Category: Biology Tags: Editorial Source Type: journals

In this issueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, v (2009). doi:10.1038/nchembio.269 (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - November 14, 2009 Category: Biology Tags: In This Issue Source Type: journals

Translating metabolic exchange with imaging mass spectrometryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dorrestein Metabolic exchange between an organism and the environment, including interactions with neighboring organisms, is important for processes of organismal development. Here we develop and use thin-layer agar natural product MALDI-TOF imaging mass spectrometry of intact bacterial colonies grown on top of the MALDI target plate to study an interaction between two species of bacteria and provide direct evidence that Bacillus subtilis silences the defensive arsenal of Streptomyces coelicolor. (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - November 8, 2009 Category: Biology Authors: Yu-Liang YangYuquan XuPaul StraightPieter C Dorrestein Tags: Brief Communication Source Type: journals

An artificial di-iron oxo-protein with phenol oxidase activityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
p; Angela Lombardi Here we report the de novo design and NMR structure of a four-helical bundle di-iron protein with phenol oxidase activity. The introduction of the cofactor-binding and phenol-binding sites required the incorporation of residues that were detrimental to the free energy of folding of the protein. Sufficient stability was, however, obtained by optimizing the sequence of a loop distant from the active site. (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - November 8, 2009 Category: Biology Authors: Marina FaiellaConcetta AndreozziRafael Torres Martin de RosalesVincenzo PavoneOrnella MaglioFlavia NastriWilliam F DeGradoAngela Lombardi Tags: Brief Communication Source Type: journals

A synergistic small-molecule combination directly eradicates diverse prion strain structuresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
amp; James Shorter (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - November 1, 2009 Category: Biology Authors: Blake E RobertsMartin L DuennwaldHuan WangChan ChungNicholas P LopreiatoElizabeth A SweenyM Noelle KnightJames Shorter Tags: Article Source Type: journals

Spatiotemporal modulation of biodiversity in a synthetic chemical-mediated ecosystemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
gchong You (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - November 1, 2009 Category: Biology Authors: Hao SongStephen PayneMeagan GrayLingchong You Tags: Article Source Type: journals

Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Joaquín Ariño (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - November 1, 2009 Category: Biology Authors: Amparo RuizAsier GonzálezIvan MuñozRaquel SerranoJ Albert AbrieErick StraussJoaquín Ariño Tags: Article Source Type: journals

Natural amino acids do not require their native tRNAs for efficient selection by the ribosomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
rginia W Cornish (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - October 25, 2009 Category: Biology Authors: Philip R EffraimJiangning WangMichael T EnglanderJosh AvinsThomas S LeyhRuben L GonzalezVirginia W Cornish Tags: Article Source Type: journals

Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
man & Scott J Hultgren (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - October 25, 2009 Category: Biology Authors: Lynette CegelskiJerome S PinknerNeal D HammerCorinne K CusumanoChia S HungErik ChorellVeronica ÅbergJennifer N WalkerPatrick C SeedFredrik AlmqvistMatthew R ChapmanScott J Hultgren Tags: Article Source Type: journals

Diverse backbone-cyclized peptides via codon reprogrammingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a methodology for the ribosomal synthesis of backbone-cyclized peptides involving genetic code reprogramming to introduce one or more nonproteinogenic amino acids. Expression of linear peptides bearing a cysteine-proline dipeptide sequence followed by glycolic acid results in self-rearrangement to a C-terminal diketopiperadine-thioester, which non-enzymatically generates a cyclized peptide. We demonstrate the ribosomal synthesis of several naturally occurring backbone-cyclized peptides and a library based on a bicyclic scaffold, and we identify bioactive sequences by screening and deconvolution. (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - October 25, 2009 Category: Biology Authors: Takashi KawakamiAtsushi OhtaMasaki OhuchiHiroshi AshigaiHiroshi MurakamiHiroaki Suga Tags: Brief Communication Source Type: journals

Research highlightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, 786 (2009). doi:10.1038/nchembio.253 (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - October 20, 2009 Category: Biology Tags: News and Views Source Type: journals

Slow growth leads to a switchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, 784 (2009). doi:10.1038/nchembio.248 Author: Keith Shearwin Synthetic biologists aim to rationally design and construct useful biological circuits. However, perturbation of host cell physiology, through the very process of turning on an artificial circuit, can give rise to unexpected emergent behaviors, such as bistability. (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - October 20, 2009 Category: Biology Authors: Keith Shearwin Tags: News and Views Source Type: journals

The physical chemistry of membrane curvatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, 783 (2009). doi:10.1038/nchembio.247 Author: Jay T Groves Membrane curvature sensing by amphipathic helices is an emergent property of the ensemble of molecules and membrane sites. New data suggest that individual molecules do not experience stronger binding to curved membranes. (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - October 20, 2009 Category: Biology Authors: Jay T Groves Tags: News and Views Source Type: journals

Locking out viral replicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Varani Few antimicrobial drugs function by directly targeting RNA. A small molecule that binds the hepatitis C viral genome by 'locking' in a particular RNA conformation to inhibit viral protein production suggests a new paradigm for drug design. (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - October 20, 2009 Category: Biology Authors: Darren W BegleyGabriele Varani Tags: News and Views Source Type: journals

The nanny model for IDPsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe here a model wherein a group of 'nanny' proteins function to protect newly synthesized IDPs from degradation by default, thereby insuring their maturation into important regulatory molecules. (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - October 20, 2009 Category: Biology Authors: Peter TsvetkovNina ReuvenYosef Shaul Tags: Commentary Source Type: journals

Post-reductionist protein science, or putting Humpty Dumpty back together againEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
henson In their native environments, proteins perform their biological roles in highly concentrated viscous solutions and in complex networks with numerous partners. Yet for many years, the normal practice has been to purify a protein of interest in order to characterize its structural and functional properties. In this Commentary, we discuss how protein scientists are now tackling the theoretical and methodological challenges of studying proteins in their physiological context. (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - October 20, 2009 Category: Biology Authors: Lila M GieraschAnne Gershenson Tags: Commentary Source Type: journals

Eyes wide openEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, 773 (2009). doi:10.1038/nchembio.258 Understanding how proteins function in isolation and in their native context requires a merging of molecular-level techniques that explore the interplay of protein structure and dynamics. (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - October 20, 2009 Category: Biology Tags: Editorial Source Type: journals

In this issueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, v (2009). doi:10.1038/nchembio.254 (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - October 20, 2009 Category: Biology Tags: In This Issue Source Type: journals

Targeting proteins for degradationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
touschek (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - October 18, 2009 Category: Biology Authors: Erin K SchraderKristine G HarstadAndreas Matouschek Tags: Review Source Type: journals

NMR spectroscopy brings invisible protein states into focusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
E Kay (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - October 18, 2009 Category: Biology Authors: Andrew J BaldwinLewis E Kay Tags: Review Source Type: journals

Computer-aided design of functional protein interactionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
rtemme (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - October 18, 2009 Category: Biology Authors: Daniel J MandellTanja Kortemme Tags: Review Source Type: journals

Coupling DNA unwinding activity with primer synthesis in the bacteriophage T4 primosomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
nt Croquette (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - October 18, 2009 Category: Biology Authors: Maria ManosasMichelle M SpieringZhihao ZhuangStephen J BenkovicVincent Croquette Tags: Article Source Type: journals

The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& Bonnie L Bassler (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - October 18, 2009 Category: Biology Authors: Robert C KellyMegan E BolithoDouglas A HigginsWenyun LuWai-Leung NgPhilip D JeffreyJoshua D RabinowitzMartin F SemmelhackFrederick M HughsonBonnie L Bassler Tags: Article Source Type: journals

LC/MS analysis of cellular RNA reveals NAD-linked RNAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
David R Liu We developed a general method to detect cellular small molecule–RNA conjugates that does not rely on the reactivity of the small molecule. This technique revealed NAD-linked RNA in Escherichia coli and Streptomyces venezuelae. Subsequent characterization showed that NAD is a 5′ modification of RNA, cannot be installed in vitro through aberrant transcriptional initiation, is only found among smaller cellular RNAs and is present at a surprisingly high abundance of ∼3,000 copies per cell. (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - October 11, 2009 Category: Biology Authors: Y Grace ChenWalter E KowtoniukIsha AgarwalYinghua ShenDavid R Liu Tags: Brief Communication Source Type: journals

The role of dynamic conformational ensembles in biomolecular recognitionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
E Wright (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - October 9, 2009 Category: Biology Authors: David D BoehrRuth NussinovPeter E Wright Tags: Perspective Source Type: journals

Dynamic refolding of IFN-γ mRNA enables it to function as PKR activator and translation templateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dynamic refolding of IFN-γ mRNA enables it to function as PKR activator and translation template Nature Chemical Biology 5, 896 (2009). doi:10.1038/nchembio.234 Authors: Smadar Cohen-Chalamish, Anat Hasson, Dahlia Weinberg, Lise Sarah Namer, Yona Banai, Farhat Osman & Raymond Kaempfer (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - October 4, 2009 Category: Biology Authors: Smadar Cohen-ChalamishAnat HassonDahlia WeinbergLise Sarah NamerYona BanaiFarhat OsmanRaymond Kaempfer Tags: Article Source Type: journals

Emergent bistability by a growth-modulating positive feedback circuitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
hong You (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - October 3, 2009 Category: Biology Authors: Cheemeng TanPhilippe MarguetLingchong You Tags: Article Source Type: journals

Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targetingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
tta & Eric D Brown (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - September 26, 2009 Category: Biology Authors: Ranjana PathaniaSoumaya ZlitniCourtney BarkerRahul DasDavid A GerritsmaJulie LebertEmilia AwuahGiuseppe MelaciniFred A CaprettaEric D Brown Tags: Article Source Type: journals

Erratum: Design, synthesis and selection of DNA-encoded small-molecule librariesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, 772 (2009). doi:10.1038/nchembio1009-772 Author: Matthew A Clark, Raksha A Acharya, Christopher C Arico-Muendel, Svetlana L Belyanskaya, Dennis R Benjamin, Neil R Carlson, Paolo A Centrella, Cynthia H Chiu, Steffen P Creaser, John W Cuozzo, Christopher P Davie, Yun Ding, G Joseph Franklin, Kurt D Franzen, Malcolm L Gefter, Steven P Hale, Nils J V Hansen, David I Israel, Jinwei Jiang, Malcolm J Kavarana, Michael S Kelley, Christopher S Kollmann, Fan Li, Kenneth Lind, Sibongile Mataruse, Patricia F Medeiros, Jeffrey A Messer, Paul Myers, Heather O'Keefe, Matthew C Oliff, Cecil E Rise, Alexander ...
Source: Nature Chemical Biology - September 24, 2009 Category: Biology Authors: Matthew A ClarkRaksha A AcharyaChristopher C Arico-MuendelSvetlana L BelyanskayaDennis R BenjaminNeil R CarlsonPaolo A CentrellaCynthia H ChiuSteffen P CreaserJohn W CuozzoChristopher P DavieYun DingG Joseph FranklinKurt D FranzenMalcolm L GefterSteven P Tags: Erratum Source Type: journals

Research highlightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, 712 (2009). doi:10.1038/nchembio.230 (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - September 24, 2009 Category: Biology Tags: News and Views Source Type: journals

DNA-catalyzed hydrolysis of DNA phosphodiestersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gates Hydrolysis of the phosphodiester linkages in DNA is a notoriously difficult reaction. Deoxyribozymes that use Zn2+ and Mn2+ ions to accelerate this reaction by a factor of one hundred million (or more) have been identified and characterized. (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - September 24, 2009 Category: Biology Authors: Mostafa I FekryKent S Gates Tags: News and Views Source Type: journals

Chemo-metabolic regulation of immune responses by TregsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sitia Chemo-metabolic processes such as redox remodeling and amino acid availability act as immunity rheostats, revealing a new mechanism regulating intercellular cross-talk between dendritic cells, regulatory T lymphocytes and effector T lymphocytes. (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - September 24, 2009 Category: Biology Authors: Anna RubartelliRoberto Sitia Tags: News and Views Source Type: journals

When two keys fit one lock, surprises followEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, 707 (2009). doi:10.1038/nchembio.225 Author: Michael Rosenblatt Parathyroid hormone (PTH) and PTH-related protein activate the same receptor but can produce divergent effects. Reports now describe two active conformations for the PTH receptor, one of which moves intracellularly—complexed with hormone and G protein—to produce a continued cAMP signal. (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - September 24, 2009 Category: Biology Authors: Michael Rosenblatt Tags: News and Views Source Type: journals

Cells' senses and sensibilitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ulsson (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - September 24, 2009 Category: Biology Authors: Shay TalJohan Paulsson Tags: Book Review Source Type: journals

Not all quiet on the noise frontEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
nter & Hana El-Samad (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - September 24, 2009 Category: Biology Authors: Emma McCullaghJustin FarlowChristopher FullerJuliet GirardJoanna Lipinski-KruszkaDan LuThomas NoriegaGeoffrey RollinsRussell SpitzerMichael TodhunterHana El-Samad Tags: Commentary Source Type: journals

Assigning responsibility and creditEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, 697 (2009). doi:10.1038/nchembio.f.13 New policies refine the responsibilities of authors and require author contribution statements in Nature Chemical Biology research papers. (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - September 24, 2009 Category: Biology Tags: Editorial Source Type: journals

In this issueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, v (2009). doi:10.1038/nchembio.231 (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - September 24, 2009 Category: Biology Tags: In This Issue Source Type: journals

Corrigendum: A 21st century revisionist's view at a turning point in enzymologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, 696 (2009). doi:10.1038/nchembio0909-696c Author: Zachary D Nagel & Judith P Klinman (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - September 22, 2009 Category: Biology Authors: Zachary D NagelJudith P Klinman Tags: Corrigendum Source Type: journals

Corrigendum: Interactive exploration of chemical space with Scaffold HunterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, 696 (2009). doi:10.1038/nchembio0909-696b Author: Stefan Wetzel, Karsten Klein, Steffen Renner, Daniel Rauh, Tudor I Oprea, Petra Mutzel & Herbert Waldmann (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - September 22, 2009 Category: Biology Authors: Stefan WetzelKarsten KleinSteffen RennerDaniel RauhTudor I OpreaPetra MutzelHerbert Waldmann Tags: Corrigendum Source Type: journals

Corrigendum: Chromatin-level regulation of biosynthetic gene clustersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Chemical Biology 5, 696 (2009). doi:10.1038/nchembio0909-696a Author: Jin Woo Bok, Yi-Ming Chiang, Edyta Szewczyk, Yazmid Reyes-Dominguez, Ashley D Davidson, James F Sanchez, Hsien-Chun Lo, Kenji Watanabe, Joseph Strauss, Berl R Oakley, Clay C C Wang & Nancy P Keller (Source: Nature Chemical Biology)
Source: Nature Chemical Biology - September 22, 2009 Category: Biology Authors: Jin Woo BokYi-Ming ChiangEdyta SzewczykYazmid Reyes-DominguezAshley D DavidsonJames F SanchezHsien-Chun LoKenji WatanabeJoseph StraussBerl R OakleyClay C C WangNancy P Keller Tags: Corrigendum Source Type: journals