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Research highlightsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Nature Genetics 41, 1167 (2009). doi:10.1038/ng1109-1167 (Source: Nature Genetics)
Source: Nature Genetics - October 28, 2009 Category: Genetics & Stem Cells Tags: Research Highlights Source Type: journals

DNA methylation is a guardian of stem cell self-renewal and multipotencyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
ikkola Epigenetic marks, such as DNA methylation and histone modifications, undergo dynamic changes during cellular differentiation and development. A new study demonstrates that DNA methylation by Dnmt1 protects essential stem cell properties in both hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs) by silencing differentiation programs that interfere with self-renewal and multipotency. (Source: Nature Genetics)
Source: Nature Genetics - October 28, 2009 Category: Genetics & Stem Cells Authors: Laurraine-Marcelle GereigeHanna K A Mikkola Tags: News and Views Source Type: journals

Not so lost in the genetic crowdemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Bansal Two new studies report improved statistics to predict whether an individual participated in a genome-wide association study based on aggregate allele or genotype frequency information. They demonstrate that it may be possible to release summary statistics for a subset of genetic markers in a study while maintaining individual privacy. (Source: Nature Genetics)
Source: Nature Genetics - October 28, 2009 Category: Genetics & Stem Cells Authors: Nicholas J SchorkVikas Bansal Tags: News and Views Source Type: journals

Genes determining blood cell traitsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Nature Genetics 41, 1161 (2009). doi:10.1038/ng1109-1161 Author: Nancy C Andrews Four genome-wide association studies report associations to a range of clinically relevant hematological traits. The candidate genes identified include many that are known to be important in iron homeostasis and red blood cell maturation. (Source: Nature Genetics)
Source: Nature Genetics - October 28, 2009 Category: Genetics & Stem Cells Authors: Nancy C Andrews Tags: News and Views Source Type: journals

Richard S. Spielman 1946–2009email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Richard S. Spielman 1946–2009 Nature Genetics 41, 1159 (2009). doi:10.1038/ng1109-1159 Author: Jurg Ott (Source: Nature Genetics)
Source: Nature Genetics - October 28, 2009 Category: Genetics & Stem Cells Authors: Jurg Ott Tags: Obituary Source Type: journals

Data divorceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Nature Genetics 41, 1157 (2009). doi:10.1038/ng1109-1157 The US Department of Health and Social Security's Public Health Service (PHS) ruled in 2005 that “Plagiarism is the appropriation of another person's ideas, processes, results, or words without giving appropriate credit.” Despite this, its Office of Research Integrity (ORI) risks giving the wrong impression that plagiarists have enduring conjugal rights to former collaborators' ideas. (Source: Nature Genetics)
Source: Nature Genetics - October 28, 2009 Category: Genetics & Stem Cells Tags: Editorial Source Type: journals

Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumorsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
amp; Andrew O M Wilkie (Source: Nature Genetics)
Source: Nature Genetics - October 25, 2009 Category: Genetics & Stem Cells Authors: Anne GorielyRuth M S HansenIndira B TaylorInge A OlesenGrete Krag JacobsenSimon J McGowanSusanne P PfeiferGilean A T McVeanEwa Rajpert-De MeytsAndrew O M Wilkie Tags: Letter Source Type: journals

Microduplications of 16p11.2 are associated with schizophreniaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Zackai, Paige Kaplan, Jaya Ganesh, Ian D Krantz, Nancy B Spinner, Patricia Roccanova, Abhishek Bhandari, Kevin Pavon, B Lakshmi, Anthony Leotta, Jude Kendall, Yoon-ha Lee, Vladimir Vacic, Sydney Gary, Lilia M Iakoucheva, Timothy J Crow, Susan L Christian, Jeffrey A Lieberman, T Scott Stroup, Terho Lehtimäki, Kaija Puura, Chad Haldeman-Englert, Justin Pearl, Meredith Goodell, Virginia L Willour, Pamela DeRosse, Jo Steele, Layla Kassem, Jessica Wolff, Nisha Chitkara, Francis J McMahon, Anil K Malhotra, James B Potash, Thomas G Schulze, Markus M Nöthen, Sven Cichon, Marcella Rietschel, Ellen Leibenluft, Vlad Kustano...
Source: Nature Genetics - October 25, 2009 Category: Genetics & Stem Cells Authors: Shane E McCarthyVladimir MakarovGeorge KirovAnjene M AddingtonJon McClellanSeungtai YoonDiana O PerkinsDiane E DickelMary KusendaOlga KrastoshevskyVerena KrauseRavinesh A KumarDetelina GrozevaDheeraj MalhotraTom WalshElaine H ZackaiPaige KaplanJaya Ganesh Tags: Letter Source Type: journals

Rearrangement of CRLF2 in B-progenitor– and Down syndrome–associated acute lymphoblastic leukemiaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Rearrangement of CRLF2 in B-progenitor– and Down syndrome–associated acute lymphoblastic leukemia Nature Genetics 41, 1243 (2009). doi:10.1038/ng.469 Authors: Charles G Mullighan, J Racquel Collins-Underwood, Letha A A Phillips, Michael G Loudin, Wei Liu, Jinghui Zhang, Jing Ma, Elaine Coustan-Smith, Richard C Harvey, Cheryl L Willman, Fady M Mikhail, Julia Meyer, Andrew J Carroll, Richard T Williams, Jinjun Cheng, Nyla A Heerema, Giuseppe Basso, Andrea Pession, Ching-Hon Pui, Susana C Raimondi, Stephen P Hunger, James R Downing, William L Carroll & Karen R Rabin (Source: Nature Genetics)
Source: Nature Genetics - October 18, 2009 Category: Genetics & Stem Cells Authors: Charles G MullighanJ Racquel Collins-UnderwoodLetha A A PhillipsMichael G LoudinWei LiuJinghui ZhangJing MaElaine Coustan-SmithRichard C HarveyCheryl L WillmanFady M MikhailJulia MeyerAndrew J CarrollRichard T WilliamsJinjun ChengNyla A HeeremaGiuseppe Ba Tags: Letter Source Type: journals

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosusemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Zhang, Qing-Wen Wang, Fei Hao, Li Ma, Xian-Bo Zuo, Fu-Sheng Zhou, Wen-Hui Du, Yi-Lin Cheng, Jian-Qiang Yang, Song-Ke Shen, Jian Li, Yu-Jun Sheng, Xiao-Xia Zuo, Wei-Fang Zhu, Fei Gao, Pei-Lian Zhang, Qing Guo, Bo Li, Min Gao, Feng-Li Xiao, Cheng Quan, Chi Zhang, Zheng Zhang, Kun-Ju Zhu, Yang Li, Da-Yan Hu, Wen-Sheng Lu, Jian-Lin Huang, Sheng-Xiu Liu, Hui Li, Yun-Qing Ren, Zai-Xing Wang, Chun-Jun Yang, Pei-Guang Wang, Wen-Ming Zhou, Yong-Mei Lv, An-Ping Zhang, Sheng-Quan Zhang, Da Lin, Yi Li, Hui Qi Low, Min Shen, Zhi-Fang Zhai, Ying Wang, Feng-Yu Zhang, Sen Yang, Jian-Jun Liu & Xue-Jun Zhang (Source: Nature Genetics)
Source: Nature Genetics - October 18, 2009 Category: Genetics & Stem Cells Authors: Jian-Wen HanHou-Feng ZhengYong CuiLiang-Dan SunDong-Qing YeZhi HuJin-Hua XuZhi-Ming CaiWei HuangGuo-Ping ZhaoHong-Fu XieHong FangQian-Jin LuJian-Hua XuXiang-Pei LiYun-Feng PanDan-Qi DengFan-Qin ZengZhi-Zhong YeXiao-Yan ZhangQing-Wen WangFei HaoLi MaXian-B Tags: Letter Source Type: journals

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosusemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Bengtsson, Solbritt Rantapää-Dahlqvist, Emily C Baechler, Elizabeth E Brown, Graciela S Alarcón, Jeffrey C Edberg, Rosalind Ramsey-Goldman, Gerald McGwin, John D Reveille, Luis M Vilá, Robert P Kimberly, Susan Manzi, Michelle A Petri, Annette Lee, Peter K Gregersen, Michael F Seldin, Lars Rönnblom, Lindsey A Criswell, Ann-Christine Syvänen, Timothy W Behrens & Robert R Graham (Source: Nature Genetics)
Source: Nature Genetics - October 18, 2009 Category: Genetics & Stem Cells Authors: Vesela GatevaJohanna K SandlingGeoff HomKimberly E TaylorSharon A ChungXin SunWard OrtmannRoman KosoyRicardo C FerreiraGunnel NordmarkIva GunnarssonElisabet SvenungssonLeonid PadyukovGunnar SturfeltAndreas JönsenAnders A BengtssonSolbritt Rantapää-Dahl Tags: Letter Source Type: journals

Global patterns of cis variation in human cells revealed by high-density allelic expression analysisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
ck Beaulieu, Robert Hamon, Alexandru Graziani, Ken Dewar, Eef Harmsen, Jacek Majewski, Harald H H Göring, Anna K Naumova, Mathieu Blanchette, Kevin L Gunderson & Tomi Pastinen (Source: Nature Genetics)
Source: Nature Genetics - October 18, 2009 Category: Genetics & Stem Cells Authors: Bing GeDmitry K PokholokTony KwanElin GrundbergLisanne MorcosDominique J VerlaanJennie LeVonda KokaKevin C L LamVincent GagnéJoana DiasRose HobermanAlexandre MontpetitMarie-Michele JolyEdward J HarveyDaniel SinnettPatrick BeaulieuRobert HamonAlexandru Gr Tags: Article Source Type: journals

Mutations in FAM134B, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
, Christoph Kaether, Vincent Timmerman & Christian A Hübner Hereditary sensory and autonomic neuropathy type II (HSAN II) leads to severe mutilations because of impaired nociception and autonomic dysfunction. Here we show that loss-of-function mutations in FAM134B, encoding a newly identified cis-Golgi protein, cause HSAN II. Fam134b knockdown results in structural alterations of the cis-Golgi compartment and induces apoptosis in some primary dorsal root ganglion neurons. This implicates FAM134B as critical in long-term survival of nociceptive and autonomic ganglion neurons. (Source: Nature Genetics)
Source: Nature Genetics - October 18, 2009 Category: Genetics & Stem Cells Authors: Ingo KurthTorsten PammingerJ Christopher HenningsDésirée SoehendraAntje K HuebnerAnnelies RotthierJonathan BaetsJan SenderekHaluk TopalogluSandra A FarrellGudrun NürnbergPeter NürnbergPeter De JongheAndreas GalChristoph KaetherVincent TimmermanChristi Tags: Brief Communication Source Type: journals

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortiumemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This study has identified new determinants of erythrocyte traits, offering insight into common variants underlying variation in erythrocyte measures. (Source: Nature Genetics)
Source: Nature Genetics - October 11, 2009 Category: Genetics & Stem Cells Authors: Santhi K GaneshNeil A ZakaiFrank J A van RooijNicole SoranzoAlbert V SmithMichael A NallsMing-Huei ChenAnna KottgenNicole L GlazerAbbas DehghanBrigitte KuhnelThor AspelundQiong YangToshiko TanakaAndrew JaffeJoshua C M BisGermaine C VerwoertAlexander Teume Tags: Article Source Type: journals

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortiumemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
David Altshuler, John R Bradley, Suzannah Bumpstead, Mary-Susan Burnett, Joseph Devaney, Angela Döring, Roberto Elosua, Stephen E Epstein, Wendy Erber, Mario Falchi, Stephen F Garner, Mohammed J R Ghori, Alison H Goodall, Rhian Gwilliam, Hakon H Hakonarson, Alistair S Hall, Naomi Hammond, Christian Hengstenberg, Thomas Illig, Inke R König, Christopher W Knouff, Ruth McPherson, Olle Melander, Vincent Mooser, Matthias Nauck, Markku S Nieminen, Christopher J O'Donnell, Leena Peltonen, Simon C Potter, Holger Prokisch, Daniel J Rader, Catherine M Rice, Robert Roberts, Veikko Salomaa, Jennifer Sambrook, Stefan Schreib...
Source: Nature Genetics - October 11, 2009 Category: Genetics & Stem Cells Authors: Nicole SoranzoTim D SpectorMassimo ManginoBrigitte KühnelAugusto RendonAlexander TeumerChristina WillenborgBenjamin WrightLi ChenMingyao LiPerttu SaloBenjamin F VoightPhilippa BurnsRoman A LaskowskiYali XueStephan MenzelDavid AltshulerJohn R BradleySuzan Tags: Article Source Type: journals

Common variants in TMPRSS6 are associated with iron status and erythrocyte volumeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5 × 10−20), transferrin saturation (combined P = 2.2 × 10−23) and erythrocyte mean cell volume (MCV, combined P = 1.1 × 10−10). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 × 10−7). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis. (Source: Nature Genetics)
Source: Nature Genetics - October 11, 2009 Category: Genetics & Stem Cells Authors: Beben BenyaminManuel A R FerreiraGonneke WillemsenScott GordonRita P S MiddelbergBrian P McEvoyJouke-Jan HottengaAnjali K HendersMegan J CampbellLeanne WallaceIan H FrazerAndrew C HeathEco J C de GeusDale R NyholtPeter M VisscherBrenda W PenninxDorret I B Tags: Brief Communication Source Type: journals

Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levelsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Marjo-Riitta Jarvelin, James Scott, Paul Elliott & Jaspal S Kooner We carried out a genome-wide association study of hemoglobin levels in 16,001 individuals of European and Indian Asian ancestry. The most closely associated SNP (rs855791) results in nonsynonymous (V736A) change in the serine protease domain of TMPRSS6 and a blood hemoglobin concentration 0.13 (95% CI 0.09–0.17) g/dl lower per copy of allele A (P = 1.6 × 10−13). Our findings suggest that TMPRSS6, a regulator of hepcidin synthesis and iron handling, is crucial in hemoglobin level maintenance. (Source: Nature Genetics)
Source: Nature Genetics - October 11, 2009 Category: Genetics & Stem Cells Authors: John C ChambersWeihua ZhangYun LiJoban SehmiMark N WassDelilah ZabanehClive HoggartHenry BayeleMark I McCarthyLeena PeltonenNelson B FreimerSurjit K SraiPatrick H MaxwellMichael J E SternbergAimo RuokonenGonçalo AbecasisMarjo-Riitta JarvelinJames ScottPa Tags: Brief Communication Source Type: journals

A new statistic and its power to infer membership in a genome-wide association study using genotype frequenciesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
ck & Nilanjan Chatterjee (Source: Nature Genetics)
Source: Nature Genetics - October 4, 2009 Category: Genetics & Stem Cells Authors: Kevin B JacobsMeredith YeagerSholom WacholderDavid CraigPeter KraftDavid J HunterJustin PaschalTeri A ManolioMargaret TuckerRobert N HooverGilles D ThomasStephen J ChanockNilanjan Chatterjee Tags: Letter Source Type: journals

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomasemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
nblatt-Rosen, Piotr Dziunycz, Justin Komisarof, Lucian R Chirieac, Christopher J LaFargue, Veit Scheble, Theresia Wilbertz, Changqing Ma, Shilpa Rao, Hiroshi Nakagawa, Douglas B Stairs, Lin Lin, Thomas J Giordano, Patrick Wagner, John D Minna, Adi F Gazdar, Chang Qi Zhu, Marcia S Brose, Ivan Cecconello, Ulysses Ribeiro Jr, Suely K Marie, Olav Dahl, Ramesh A Shivdasani, Ming-Sound Tsao, Mark A Rubin, Kwok K Wong, Aviv Regev, William C Hahn, David G Beer, Anil K Rustgi & Matthew Meyerson (Source: Nature Genetics)
Source: Nature Genetics - October 4, 2009 Category: Genetics & Stem Cells Authors: Adam J BassHideo WatanabeCraig H MermelSoyoung YuSven PernerRoel G VerhaakSo Young KimLeslie WardwellPablo TamayoIrit Gat-ViksAlex H RamosMichele S WooBarbara A WeirGad GetzRameen BeroukhimMichael O'KellyAmit DuttOrit Rozenblatt-RosenPiotr DziunyczJustin Tags: Letter Source Type: journals

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restrictionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
ik W Jacobsen & Frank Rosenbauer (Source: Nature Genetics)
Source: Nature Genetics - October 4, 2009 Category: Genetics & Stem Cells Authors: Ann-Marie BröskeLena VockentanzShabnam KharaziMatthew R HuskaElena ManciniMarina SchellerChristiane KuhlAndreas EnnsMarco PrinzRudolf JaenischClaus NerlovAchim LeutzMiguel A Andrade-NavarroSten Eirik W JacobsenFrank Rosenbauer Tags: Article Source Type: journals

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studiesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Authors: (Source: Nature Genetics)
Source: Nature Genetics - October 4, 2009 Category: Genetics & Stem Cells Tags: Article Source Type: journals

T (brachyury) gene duplication confers major susceptibility to familial chordomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
mp; Michael J Kelley Using high-resolution array-CGH, we identified unique duplications of a region on 6q27 in four multiplex families with at least three cases of chordoma, a cancer of presumed notochordal origin. The duplicated region contains only the T (brachyury) gene, which is important in notochord development and is expressed in most sporadic chordomas. Our findings highlight the value of screening for complex genomic rearrangements in searches for cancer-susceptibility genes. (Source: Nature Genetics)
Source: Nature Genetics - October 4, 2009 Category: Genetics & Stem Cells Authors: Xiaohong R YangDavid NgDavid A AlcortaNorbert J LiebschEamonn SheridanSufeng LiAlisa M GoldsteinDilys M ParryMichael J Kelley Tags: Brief Communication Source Type: journals

Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Nature Genetics 41, 1156 (2009). doi:10.1038/ng1009-1156d Author: Denise Harold, Richard Abraham, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Marian L Hamshere, Jaspreet Singh Pahwa, Valentina Moskvina, Kimberley Dowzell, Amy Williams, Nicola Jones, Charlene Thomas, Alexandra Stretton, Angharad R Morgan, Simon Lovestone, John Powell, Petroula Proitsi, Michelle K Lupton, Carol Brayne, David C Rubinsztein, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Kevin Morgan, Kristelle S Brown, Peter A Passmore, David Craig, Bernadette McGuinness, Stephen Todd, Clive Holmes, David Mann, A David Smith, Seth Love, Patrick G Kehoe, Joh...
Source: Nature Genetics - September 28, 2009 Category: Genetics & Stem Cells Authors: Denise HaroldRichard AbrahamPaul HollingworthRebecca SimsAmy GerrishMarian L HamshereJaspreet Singh PahwaValentina MoskvinaKimberley DowzellAmy WilliamsNicola JonesCharlene ThomasAlexandra StrettonAngharad R MorganSimon LovestoneJohn PowellPetroula Proits Tags: Erratum Source Type: journals

Erratum: Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemiaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Nature Genetics 41, 1156 (2009). doi:10.1038/ng1009-1156c Author: Johan Rung, Stéphane Cauchi, Anders Albrechtsen, Lishuang Shen, Ghislain Rocheleau, Christine Cavalcanti-Proença, François Bacot, Beverley Balkau, Alexandre Belisle, Knut Borch-Johnsen, Guillaume Charpentier, Christian Dina, Emmanuelle Durand, Paul Elliott, Samy Hadjadj, Marjo-Riitta Järvelin, Jaana Laitinen, Torsten Lauritzen, Michel Marre, Alexander Mazur, David Meyre, Alexandre Montpetit, Charlotta Pisinger, Barry Posner, Pernille Poulsen, Anneli Pouta, Marc Prentki, Rasmus Ribel-Madsen, Aimo Ruokonen, Anelli Sandbaek, David Serre, ...
Source: Nature Genetics - September 28, 2009 Category: Genetics & Stem Cells Authors: Johan RungStéphane CauchiAnders AlbrechtsenLishuang ShenGhislain RocheleauChristine Cavalcanti-ProençaFrançois BacotBeverley BalkauAlexandre BelisleKnut Borch-JohnsenGuillaume CharpentierChristian DinaEmmanuelle DurandPaul ElliottSamy HadjadjMarjo-Riit Tags: Erratum Source Type: journals

Erratum: Elucidating the role of 8q24 in colorectal canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Nature Genetics 41, 1156 (2009). doi:10.1038/ng1009-1156b Author: Olivier Harismendy & Kelly A Frazer (Source: Nature Genetics)
Source: Nature Genetics - September 28, 2009 Category: Genetics & Stem Cells Authors: Olivier HarismendyKelly A Frazer Tags: Erratum Source Type: journals

Corrigendum: Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Nature Genetics 41, 1156 (2009). doi:10.1038/ng1009-1156a Author: Xifeng Wu, Yuanqing Ye, Lambertus A Kiemeney, Patrick Sulem, Thorunn Rafnar, Giuseppe Matullo, Daniela Seminara, Teruhiko Yoshida, Norihisa Saeki, Angeline S Andrew, Colin P Dinney, Bogdan Czerniak, Zuo-feng Zhang, Anne E Kiltie, D Timothy Bishop, Paolo Vineis, Stefano Porru, Frank Buntinx, Eliane Kellen, Maurice P Zeegers, Rajiv Kumar, Peter Rudnai, Eugene Gurzau, Kvetoslava Koppova, Jose Ignacio Mayordomo, Manuel Sanchez, Berta Saez, Annika Lindblom, Petra de Verdier, Gunnar Steineck, Gordon B Mills, Alan Schned, Shen-Chih Chang, Jie Lin, David W Chang,...
Source: Nature Genetics - September 28, 2009 Category: Genetics & Stem Cells Authors: Xifeng WuYuanqing YeLambertus A KiemeneyPatrick SulemThorunn RafnarGiuseppe MatulloDaniela SeminaraTeruhiko YoshidaNorihisa SaekiAngeline S AndrewColin P DinneyBogdan CzerniakZuo-feng ZhangAnne E KiltieD Timothy BishopPaolo VineisStefano PorruFrank Buntin Tags: Corrigendum Source Type: journals

Research highlightsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Nature Genetics 41, 1052 (2009). doi:10.1038/ng1009-1052 (Source: Nature Genetics)
Source: Nature Genetics - September 28, 2009 Category: Genetics & Stem Cells Tags: Research Highlights Source Type: journals

Tcf proteins are deeply rooted in skinemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Nature Genetics 41, 1050 (2009). doi:10.1038/ng1009-1050 Author: David M Owens Adult mammalian tissues are maintained by multipotent stem cells, many of which are highly responsive to soluble Wnt proteins. A new study reports the requirement of two Tcf family members, Tcf3 and Tcf4, in the development and maintenance of epithelial stem cells in skin through Wnt-dependent and -independent processes. (Source: Nature Genetics)
Source: Nature Genetics - September 28, 2009 Category: Genetics & Stem Cells Authors: David M Owens Tags: News and Views Source Type: journals

Alzheimer’s disease beyond APOEemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Alzheimer’s disease beyond APOE Nature Genetics 41, 1047 (2009). doi:10.1038/ng1009-1047 Authors: Michael A van Es & Leonard H van den Berg Two genome-wide association studies together report three new susceptibility loci for late-onset Alzheimer’s disease. CLU, PICALM and CR1 may be involved in amyloid-β clearance from the brain. (Source: Nature Genetics)
Source: Nature Genetics - September 28, 2009 Category: Genetics & Stem Cells Authors: Michael A van EsLeonard H van den Berg Tags: News and Views Source Type: journals

Data producers deserve citation creditemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Nature Genetics 41, 1045 (2009). doi:10.1038/ng1009-1045 Datasets released to public databases in advance of (or with) research publications should be given digital object identifiers to allow databases and journals to give quantitative citation credit to the data producers and curators. (Source: Nature Genetics)
Source: Nature Genetics - September 28, 2009 Category: Genetics & Stem Cells Tags: Editorial Source Type: journals

In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progressionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
ael T Hemann Mouse models have markedly improved our understanding of cancer development and tumor biology. However, these models have shown limited efficacy as tractable systems for unbiased genetic experimentation. Here, we report the adaptation of loss-of-function screening to mouse models of cancer. Specifically, we have been able to introduce a library of shRNAs into individual mice using transplantable Eμ-myc lymphoma cells. This approach has allowed us to screen nearly 1,000 genetic alterations in the context of a single tumor-bearing mouse. These experiments have identified a central role for regulators of act...
Source: Nature Genetics - September 26, 2009 Category: Genetics & Stem Cells Authors: Corbin E MeachamEmily E HoEsther DubrovskyFrank B GertlerMichael T Hemann Tags: Letter Source Type: journals

Retraction: Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsiesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Nature Genetics 41, 1043 (2009). doi:10.1038/ng0909-1043 Author: Karsten Haug, Maike Warnstedt, Alexi K Alekov, Thomas Sander, Alfredo Ramírez, Barbara Poser, Snezana Maljevic, Simon Hebeisen, Christian Kubisch, Johannes Rebstock, Steve Horvath, Kerstin Hallmann, Joern S Dullinger, Birgit Rau, Fritz Haverkamp, Stefan Beyenburg, Herbert Schulz, Dieter Janz, Bernd Giese, Gerhard Müller-Newen, Peter Propping, Christian E Elger, Christoph Fahlke, Holger Lerche & Armin Heils (Source: Nature Genetics)
Source: Nature Genetics - September 22, 2009 Category: Genetics & Stem Cells Authors: Karsten HaugMaike WarnstedtAlexi K AlekovThomas SanderAlfredo RamírezBarbara PoserSnezana MaljevicSimon HebeisenChristian KubischJohannes RebstockSteve HorvathKerstin HallmannJoern S DullingerBirgit RauFritz HaverkampStefan BeyenburgHerbert SchulzDieter Tags: Retraction Source Type: journals

Research Highlightsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Nature Genetics 41, 962 (2009). doi:10.1038/ng0909-962 (Source: Nature Genetics)
Source: Nature Genetics - September 22, 2009 Category: Genetics & Stem Cells Tags: Research Highlights Source Type: journals

An uphill battle toward pluripotencyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Nature Genetics 41, 960 (2009). doi:10.1038/ng0909-960 Author: Thomas Graf The discovery that a cocktail of transcription factors can reprogram somatic cells into induced pluripotent stem (iPS) cells keeps revealing new secrets of cell fate specification. A new study with hematopoietic cells shows that progenitor cells are far more susceptible than differentiated cells to reprogramming. (Source: Nature Genetics)
Source: Nature Genetics - September 22, 2009 Category: Genetics & Stem Cells Authors: Thomas Graf Tags: News and Views Source Type: journals

Closing the gap between genotype and phenotypeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Nature Genetics 41, 958 (2009). doi:10.1038/ng0909-958 Author: Peter K. Gregersen Making causative connections between genotypic and phenotypic variation is a major challenge for geneticists engaged in the study of human disease. A study drawing this connection for a type 1 diabetes risk locus now demonstrates the importance of focusing on specific quantitative traits and studying them in normal subjects. (Source: Nature Genetics)
Source: Nature Genetics - September 22, 2009 Category: Genetics & Stem Cells Authors: Peter K. Gregersen Tags: News and Views Source Type: journals

Inherited susceptibility to pediatric acute lymphoblastic leukemiaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Nature Genetics 41, 957 (2009). doi:10.1038/ng0909-957 Author: Ross L Levine Although genome-wide analyses have identified somatic alterations contributing to the pathogenesis of pediatric acute lymphoblastic leukemia (ALL), few studies have identified germline variants conferring risk of this disease. Two reports now provide the first genome-wide glimpse into the role of inherited alleles in ALL pathogenesis. (Source: Nature Genetics)
Source: Nature Genetics - September 22, 2009 Category: Genetics & Stem Cells Authors: Ross L Levine Tags: News and Views Source Type: journals

CLCN2 variants in idiopathic generalized epilepsyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
46;rn S Dullinger, Birgit Rau, Fritz Haverkamp, Stefan Beyenburg, Herbert Schulz, Dieter Janz, Bernd Giese, Gerhard Müller-Newen, Peter Propping, Christian E Elger, Christoph Fahlke & Holger Lerche (Source: Nature Genetics)
Source: Nature Genetics - September 22, 2009 Category: Genetics & Stem Cells Authors: Ailing Kleefuß-LieWaltraut FriedlSven CichonKarsten HaugMaike WarnstedtAlexi AlekovThomas SanderAlfredo RamirezBarbara PoserSnezana MaljevicSimon HebeisenChristian KubischJohannes RebstockSteve HorvathKerstin HallmannJörn S DullingerBirgit RauFritz Have Tags: Correspondence Source Type: journals

Twelve lords a-leapingemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Nature Genetics 41, 953 (2009). doi:10.1038/ng0909-953 The UK House of Lords Science and Technology Committee reports that genomic medicine is already in practice but needs a coordinated set of infrastructural and training systems to allow the healthcare system to cope. (Source: Nature Genetics)
Source: Nature Genetics - September 22, 2009 Category: Genetics & Stem Cells Tags: Editorial Source Type: journals

Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibilityemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
ahlfors, Teuvo Tammela, Joan P Breyer, Kate M McReynolds, Kevin M Bradley, Berta Saez, Javier Godino, Sebastian Navarrete, Fernando Fuertes, Laura Murillo, Eduardo Polo, Katja K Aben, Inge M van Oort, Brian K Suarez, Brian T Helfand, Donghui Kan, Carlo Zanon, Michael L Frigge, Kristleifur Kristjansson, Jeffrey R Gulcher, Gudmundur V Einarsson, Eirikur Jonsson, William J Catalona, Jose I Mayordomo, Lambertus A Kiemeney, Jeffrey R Smith, Johanna Schleutker, Rosa B Barkardottir, Augustine Kong, Unnur Thorsteinsdottir, Thorunn Rafnar & Kari Stefansson (Source: Nature Genetics)
Source: Nature Genetics - September 19, 2009 Category: Genetics & Stem Cells Authors: Julius GudmundssonPatrick SulemDaniel F GudbjartssonThorarinn BlondalArnaldur GylfasonBjarni A AgnarssonKristrun R BenediktsdottirDroplaug N MagnusdottirGudbjorg OrlygsdottirMargret JakobsdottirSimon N StaceyAsgeir SigurdssonTiina WahlforsTeuvo TammelaJoa Tags: Letter Source Type: journals

Identification of seven new prostate cancer susceptibility loci through a genome-wide association studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
d, Elaine A Ostrander, Sue A Ingles, Esther M John, Stephen N Thibodeau, Daniel Schaid, Jong Y Park, Amanda Spurdle, Judith Clements, Joanne L Dickinson, Christiane Maier, Walther Vogel, Thilo Dörk, Timothy R Rebbeck, Kathleen A Cooney, Lisa Cannon-Albright, Pierre O Chappuis, Pierre Hutter, Maurice Zeegers, Radka Kaneva, Hong-Wei Zhang, Yong-Jie Lu, William D Foulkes, Dallas R English, Daniel A Leongamornlert, Malgorzata Tymrakiewicz, Jonathan Morrison, Audrey T Ardern-Jones, Amanda L Hall, Lynne T O'Brien, Rosemary A Wilkinson, Edward J Saunders, Elizabeth C Page, Emma J Sawyer, Stephen M Edwards, David P Dearnaley,...
Source: Nature Genetics - September 19, 2009 Category: Genetics & Stem Cells Authors: Rosalind A EelesZsofia Kote-JaraiAli Amin Al OlamaGraham G GilesMichelle GuyGianluca SeveriKenneth MuirJohn L HopperBrian E HendersonChristopher A HaimanJohanna SchleutkerFreddie C HamdyDavid E NealJenny L DonovanJanet L StanfordElaine A OstranderSue A In Tags: Letter Source Type: journals

Multiple loci on 8q24 associated with prostate cancer susceptibilityemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
P Dearnaley, Audrey T Ardern-Jones, Amanda L Hall, Lynne T O'Brien, Rosemary A Wilkinson, Emma Sawyer, Artitaya Lophatananon, Alan Horwich, Robert A Huddart, Vincent S Khoo, Christopher C Parker, Christopher J Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Colin Cooper, Jenny L Donovan, Freddie C Hamdy, David E Neal, Rosalind A Eeles & Douglas F Easton Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations a...
Source: Nature Genetics - September 19, 2009 Category: Genetics & Stem Cells Authors: Ali Amin Al OlamaZsofia Kote-JaraiGraham G GilesMichelle GuyJonathan MorrisonGianluca SeveriDaniel A LeongamornlertMalgorzata TymrakiewiczSameer JhavarEd SaundersJohn L HopperMelissa C SoutheyKenneth R MuirDallas R EnglishDavid P DearnaleyAudrey T Ardern- Tags: Brief Communication Source Type: journals

Identification of a new prostate cancer susceptibility locus on chromosome 8q24email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 × 10−10, heterozygote OR = 1.17, 95% CI 1.10–1.24; homozygote OR = 1.33, 95% CI 1.21–1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24. (Source: Nature Genetics)
Source: Nature Genetics - September 19, 2009 Category: Genetics & Stem Cells Authors: Meredith YeagerNilanjan ChatterjeeJulia CiampaKevin B JacobsJesus Gonzalez-BosquetRichard B HayesPeter KraftSholom WacholderNick OrrSonja BerndtKai YuAmy HutchinsonZhaoming WangLaufey AmundadottirHeather Spencer FeigelsonMichael J ThunW Ryan DiverDemetriu Tags: Brief Communication Source Type: journals

A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signalingemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
David Bilder A prevailing paradigm posits that Polycomb Group (PcG) proteins maintain stem cell identity by repressing differentiation genes, and abundant evidence points to an oncogenic role for PcG proteins in human cancer. Here we show using Drosophila melanogaster that a conventional PcG complex can also have a potent tumor suppressor activity. Mutations in any core PRC1 component cause pronounced hyperproliferation of eye imaginal tissue, accompanied by deregulation of epithelial architecture. The mitogenic JAK-STAT pathway is strongly and specifically activated in mutant tissue; activation is driven by transcriptiona...
Source: Nature Genetics - September 12, 2009 Category: Genetics & Stem Cells Authors: Anne-Kathrin ClassenBrandon D BunkerKieran F HarveyThomas VaccariDavid Bilder Tags: Letter Source Type: journals

Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis Cemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We report a genome-wide association study (GWAS) to null virological response (NVR) in the treatment of patients with hepatitis C virus (HCV) genotype 1 within a Japanese population. We found two SNPs near the gene IL28B on chromosome 19 to be strongly associated with NVR (rs12980275, P = 1.93 × 10−13, and rs8099917, 3.11 × 10−15). We replicated these associations in an independent cohort (combined P values, 2.84 × 10−27 (OR = 17.7; 95% CI = 10.0–31.3) and 2.68 × 10−32 (OR = 27.1; 95% CI = 14.6–50.3), respectively). Compared to NVR, these SNPs were also associated wit...
Source: Nature Genetics - September 12, 2009 Category: Genetics & Stem Cells Authors: Yasuhito TanakaNao NishidaMasaya SugiyamaMasayuki KurosakiKentaro MatsuuraNaoya SakamotoMina NakagawaMasaaki KorenagaKeisuke HinoShuhei HigeYoshito ItoEiji MitaEiji TanakaSatoshi MochidaYoshikazu MurawakiMasao HondaAkito SakaiYoichi HiasaShuhei Nishiguchi Tags: Letter Source Type: journals

IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We report an association to SVR within the gene region encoding interleukin 28B (IL28B, also called IFNλ3; rs8099917 combined P = 9.25 × 10−9, OR = 1.98, 95% CI = 1.57–2.52). IL28B contributes to viral resistance and is known to be upregulated by interferons and by RNA virus infection. These data suggest that host genetics may be useful for the prediction of drug response, and they also support the investigation of the role of IL28B in the treatment of HCV and in other diseases treated with IFN-α. (Source: Nature Genetics)
Source: Nature Genetics - September 12, 2009 Category: Genetics & Stem Cells Tags: Letter Source Type: journals

Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signalingemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
iacomo Cavalli (Source: Nature Genetics)
Source: Nature Genetics - September 12, 2009 Category: Genetics & Stem Cells Authors: Anne-Marie MartinezBernd SchuettengruberSamy SakrAna JanicCayetano GonzalezGiacomo Cavalli Tags: Article Source Type: journals

Interferon-alfa, interferon-λ and hepatitis Cemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Interferon-alfa, interferon-λ and hepatitis C Nature Genetics 41, 1048 (2009). doi:10.1038/ng.453 Author: Thomas R O'Brien Three new studies report genetic variants near IL28B, which encodes interferon-λ3 (interleukin 28B), are associated with response to treatment of chronic hepatitis C virus infection with interferon-alfa/ribavirin combination therapy. This renews interest in how interferons suppress viremia and could lead to improved clinical decisions for chronic HCV infection treatment based on individual genotype. (Source: Nature Genetics)
Source: Nature Genetics - September 12, 2009 Category: Genetics & Stem Cells Authors: Thomas R O'Brien Tags: News and Views Source Type: journals

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemiaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
d, Paul Elliott, Samy Hadjadj, Marjo-Riitta Järvelin, Jaana Laitinen, Torsten Lauritzen, Michel Marre, Alexander Mazur, David Meyre, Alexandre Montpetit, Charlotta Pisinger, Barry Posner, Pernille Poulsen, Anneli Pouta, Marc Prentki, Rasmus Ribel-Madsen, Aimo Ruokonen, Anelli Sandbaek, David Serre, Jean Tichet, Martine Vaxillaire, Jørgen F P Wojtaszewski, Allan Vaag, Torben Hansen, Constantin Polychronakos, Oluf Pedersen, Philippe Froguel & Robert Sladek Genome-wide association studies have identified common variants that only partially explain the genetic risk for type 2 diabetes (T2D). Using genome-wide ass...
Source: Nature Genetics - September 5, 2009 Category: Genetics & Stem Cells Authors: Johan RungStéphane CauchiAnders AlbrechtsenLishuang ShenGhislain RocheleauChristine Cavalcanti-ProençaFrançois BacotBeverley BalkauAlexandre BelisleKnut Borch-JohnsenGuillaume CharpentierChristian DinaEmmanuelle DurandPaul ElliottSamy HadjadjMarjo-Riit Tags: Letter Source Type: journals

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
33;vet, Pascale Barberger-Gateau, Sebastiaan Engelborghs, Peter De Deyn, Ignacio Mateo, Ana Franck, Seppo Helisalmi, Elisa Porcellini, Olivier Hanon, Marian M de Pancorbo, Corinne Lendon, Carole Dufouil, Céline Jaillard, Thierry Leveillard, Victoria Alvarez, Paolo Bosco, Michelangelo Mancuso, Francesco Panza, Benedetta Nacmias, Paola Bossù, Paola Piccardi, Giorgio Annoni, Davide Seripa, Daniela Galimberti, Didier Hannequin, Federico Licastro, Hilkka Soininen, Karen Ritchie, Hélène Blanché, Jean-François Dartigues, Christophe Tzourio, Ivo Gut, Christine Van Broeckhoven, Annick Alpérovitch,...
Source: Nature Genetics - September 5, 2009 Category: Genetics & Stem Cells Authors: Jean-Charles LambertSimon HeathGael EvenDominique CampionKristel SleegersMikko HiltunenOnofre CombarrosDiana ZelenikaMaria J BullidoBéatrice TavernierLuc LetenneurKarolien BettensClaudine BerrFlorence PasquierNathalie FiévetPascale Barberger-GateauSebas Tags: Letter Source Type: journals

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
e, John Powell, Petroula Proitsi, Michelle K Lupton, Carol Brayne, David C Rubinsztein, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Kevin Morgan, Kristelle S Brown, Peter A Passmore, David Craig, Bernadette McGuinness, Stephen Todd, Clive Holmes, David Mann, A David Smith, Seth Love, Patrick G Kehoe, John Hardy, Simon Mead, Nick Fox, Martin Rossor, John Collinge, Wolfgang Maier, Frank Jessen, Britta Schürmann, Hendrik van den Bussche, Isabella Heuser, Johannes Kornhuber, Jens Wiltfang, Martin Dichgans, Lutz Frölich, Harald Hampel, Michael Hüll, Dan Rujescu, Alison M Goate, John S K Kauwe, Carlos Cruchaga, Pe...
Source: Nature Genetics - September 5, 2009 Category: Genetics & Stem Cells Authors: Denise HaroldRichard AbrahamPaul HollingworthRebecca SimsAmy GerrishMarian L HamshereJaspreet Singh PahwaValentina MoskvinaKimberley DowzellAmy WilliamsNicola JonesCharlene ThomasAlexandra StrettonAngharad R MorganSimon LovestoneJohn PowellPetroula Proits Tags: Letter Source Type: journals