Nature Immunology
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Research Highlights
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Nature Immunology 10, 1236 (2009). doi:10.1038/ni1209-1236 (Source: Nature Immunology)
Source: Nature Immunology - November 16, 2009 Category: Allergy & Immunology Tags: Research Highlights Source Type: journals
B cell memory: how to start and when to end
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lliams
Antigen-driven selection in germinal centers lays the foundation of effective B cell memory. Two reports in this issue reveal novel mechanisms that control effective formation of germinal centers and their long-term persistence in vivo. (Source: Nature Immunology)
Source: Nature Immunology - November 16, 2009 Category: Allergy & Immunology Authors: Nadege PelletierMichael G McHeyzer-Williams Tags: News and Views Source Type: journals
T cells need Nod too?
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Croft
Nucleotide-binding oligomerization domain 2 (Nod2) is required for sensing of intracellular bacteria and subsequent inflammatory responses. Unexpectedly, new evidence suggests that Nod2 influences T helper cell signaling, proliferation and differentiation and effector responses against Toxoplasma gondii. (Source: Nature Immunology)
Source: Nature Immunology - November 16, 2009 Category: Allergy & Immunology Authors: Shahram Salek-ArdakaniMichael Croft Tags: News and Views Source Type: journals
MicroRNA-managing the TH-17 inflammatory response
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D Miller
The differentiation of interleukin 17–producing helper T cells is controlled by a complex network of cytokines, signaling pathways and transcription factors. Regulation by microRNA particles can now be added to this list. (Source: Nature Immunology)
Source: Nature Immunology - November 16, 2009 Category: Allergy & Immunology Authors: Aaron J MartinLiang ZhouStephen D Miller Tags: News and Views Source Type: journals
Data management: it starts at the bench
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rles Quinn
Data management has been neglected but should be made an integral activity in all research laboratories. Chaussabel and colleagues discuss how to implement this at the bench. (Source: Nature Immunology)
Source: Nature Immunology - November 16, 2009 Category: Allergy & Immunology Authors: Damien ChaussabelHideki UenoJacques BanchereauCharles Quinn Tags: Commentary Source Type: journals
Science: a common language
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Nature Immunology 10, 1223 (2009). doi:10.1038/ni1209-1223
Science and technology can be used to build relations between countries. Thus, scientific diplomacy is becoming increasingly important. (Source: Nature Immunology)
Source: Nature Immunology - November 16, 2009 Category: Allergy & Immunology Tags: Editorial Source Type: journals
Dendritic cell subsets in primary and secondary T cell responses at body surfaces
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arbone (Source: Nature Immunology)
Source: Nature Immunology - November 16, 2009 Category: Allergy & Immunology Authors: William R HeathFrancis R Carbone Tags: Review Source Type: journals
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production
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lissa K Deenick, Stuart G Tangye, Tyani D Chan, Tahra Camidge, Robert Brink, Carola G Vinuesa, Facundo D Batista, Richard J Cornall & Christopher C Goodnow (Source: Nature Immunology)
Source: Nature Immunology - November 8, 2009 Category: Allergy & Immunology Authors: Katrina L RandallTeresa LambeAndy JohnsonBebhinn TreanorEdyta KucharskaHeather DomaschenzBelinda WhittleLina E TzeAnselm EndersTanya L CrockfordTiphaine Bouriez-JonesDuncan AlstonJason G CysterMichael J LenardoFabienne MackayElissa K DeenickStuart G Tangy Tags: Article Source Type: journals
PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4
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; Zhengfan Jiang (Source: Nature Immunology)
Source: Nature Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Fuping YouHui SunXiang ZhouWenxiang SunShimin LiangZhonghe ZhaiZhengfan Jiang Tags: Article Source Type: journals
T cell–intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii
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T cell–intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii
Nature Immunology 10, 1267 (2009). doi:10.1038/ni.1816
Authors: Michael H Shaw, Thornik Reimer, Carmen Sánchez-Valdepeñas, Neil Warner, Yun-Gi Kim, Manuel Fresno & Gabriel Nuñez (Source: Nature Immunology)
Source: Nature Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Michael H ShawThornik ReimerCarmen Sánchez-ValdepeñasNeil WarnerYun-Gi KimManuel FresnoGabriel Nuñez Tags: Article Source Type: journals
Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment
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Bing Sun & Chen Dong (Source: Nature Immunology)
Source: Nature Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Xuexian O YangPornpimon AngkasekwinaiJinfang ZhuJuan PengZhiduo LiuRoza NurievaXikui LiuYeonseok ChungSeon Hee ChangBing SunChen Dong Tags: Article Source Type: journals
Multiple layers of B cell memory with different effector functions
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ude-Agnès Reynaud & Jean-Claude Weill (Source: Nature Immunology)
Source: Nature Immunology - October 25, 2009 Category: Allergy & Immunology Authors: Ismail DoganBarbara BertocciValérie VilmontFrédéric DelbosJérome MégretSébastien StorckClaude-Agnès ReynaudJean-Claude Weill Tags: Article Source Type: journals
Research Highlights
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Nature Immunology 10, 1145 (2009). doi:10.1038/ni1109-1145 (Source: Nature Immunology)
Source: Nature Immunology - October 20, 2009 Category: Allergy & Immunology Tags: Research Highlights Source Type: journals
Positively selecting peptides: their job does not end in the thymus
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Gagnon
Peptides able to positively select major histocompatibility complex class II–restricted thymocytes have not yet been defined. Two new reports identify and ascribe important extrathymic functions to several positively selecting peptides for CD4+ T cells. (Source: Nature Immunology)
Source: Nature Immunology - October 20, 2009 Category: Allergy & Immunology Authors: Kai W WucherpfennigEtienne Gagnon Tags: News and Views Source Type: journals
The gut feeling of Treg cells: IL-10 is the silver lining during colitis
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endran
Regulatory T cells that express the transcription factor Foxp3 are pivotal in suppressing autoimmune responses. A report in this issue describes a key role for interleukin 10 produced by lamina propria macrophages in maintaining Foxp3 expression during inflammatory responses in the intestine. (Source: Nature Immunology)
Source: Nature Immunology - October 20, 2009 Category: Allergy & Immunology Authors: Derya UnutmazBali Pulendran Tags: News and Views Source Type: journals
TLR2 joins the interferon gang
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ornung
The induction of type I interferon is a critical checkpoint in antiviral immunity. Toll-like receptor 2 can unexpectedly induce type I interferon in the subset of inflammatory monocytes during infection with vaccinia virus. (Source: Nature Immunology)
Source: Nature Immunology - October 20, 2009 Category: Allergy & Immunology Authors: Franz BauernfeindVeit Hornung Tags: News and Views Source Type: journals
NDP52: the missing link between ubiquitinated bacteria and autophagy
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R Roy
Mammalian cells ubiquitinate bacteria that erroneously enter the cytosol and target these intruding microbes for destruction by autophagy. New work shows that the protein NDP52 directly binds to ubiquitinated bacteria and facilitates the assembly of an autophagic membrane that surrounds these invaders. (Source: Nature Immunology)
Source: Nature Immunology - October 20, 2009 Category: Allergy & Immunology Authors: Stanimir IvanovCraig R Roy Tags: News and Views Source Type: journals
Navigating the leukocyte signaling maze guided by Ariadne's thread
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Tsoukas
Ariadne is the legendary Minoan goddess of the Labyrinth. The term 'Ariadne's thread' is used to describe the understanding of complex issues. Immunologists attending the 5th Leukocyte Signal Transduction Workshop discussed the Ariadne's thread woven about intracellular signaling pathways. (Source: Nature Immunology)
Source: Nature Immunology - October 20, 2009 Category: Allergy & Immunology Authors: Amnon AltmanGary A KoretzkyConstantine D Tsoukas Tags: Meeting Report Source Type: journals
Lessons learned
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Nature Immunology 10, 1133 (2009). doi:10.1038/ni1109-1133
Additional work is needed to prepare for the next pandemic viral outbreak. (Source: Nature Immunology)
Source: Nature Immunology - October 20, 2009 Category: Allergy & Immunology Tags: Editorial Source Type: journals
A coming-of-age story: activation-induced cytidine deaminase turns 10
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vasiliou (Source: Nature Immunology)
Source: Nature Immunology - October 19, 2009 Category: Allergy & Immunology Authors: Rebecca K DelkerSebastian D FugmannF Nina Papavasiliou Tags: Review Source Type: journals
Defective survival of naive CD8+ T lymphocytes in the absence of the β3 regulatory subunit of voltage-gated calcium channels
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Defective survival of naive CD8+ T lymphocytes in the absence of the β3 regulatory subunit of voltage-gated calcium channels
Nature Immunology 10, 1275 (2009). doi:10.1038/ni.1793
Authors: Mithilesh K Jha, Abdallah Badou, Marcel Meissner, John E McRory, Marc Freichel, Veit Flockerzi & Richard A Flavell (Source: Nature Immunology)
Source: Nature Immunology - October 18, 2009 Category: Allergy & Immunology Authors: Mithilesh K JhaAbdallah BadouMarcel MeissnerJohn E McRoryMarc FreichelVeit FlockerziRichard A Flavell Tags: Article Source Type: journals
MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis
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ng Wu & Gang Pei (Source: Nature Immunology)
Source: Nature Immunology - October 18, 2009 Category: Allergy & Immunology Authors: Changsheng DuChang LiuJiuhong KangGuixian ZhaoZhiqiang YeShichao HuangZhenxin LiZhiying WuGang Pei Tags: Article Source Type: journals
Structural basis of receptor sharing by interleukin 17 cytokines
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r Garcia (Source: Nature Immunology)
Source: Nature Immunology - October 18, 2009 Category: Allergy & Immunology Authors: Lauren K ElySuzanne FischerK Christopher Garcia Tags: Article Source Type: journals
The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria
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Felix Randow (Source: Nature Immunology)
Source: Nature Immunology - October 10, 2009 Category: Allergy & Immunology Authors: Teresa L M ThurstonGrigory RyzhakovStuart BloorNatalia von MuhlinenFelix Randow Tags: Article Source Type: journals
Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands
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y M Barton (Source: Nature Immunology)
Source: Nature Immunology - October 3, 2009 Category: Allergy & Immunology Authors: Roman BarbalatLaura LauRichard M LocksleyGregory M Barton Tags: Article Source Type: journals
An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a
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Mark M Davis (Source: Nature Immunology)
Source: Nature Immunology - October 3, 2009 Category: Allergy & Immunology Authors: Peter J R EbertShan JiangJianming XieQi-Jing LiMark M Davis Tags: Article Source Type: journals
An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells
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; Paul M Allen (Source: Nature Immunology)
Source: Nature Immunology - October 3, 2009 Category: Allergy & Immunology Authors: Wan-Lin LoNathan J FelixJames J WaltersHenry RohrsMichael L GrossPaul M Allen Tags: Article Source Type: journals
Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation
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Wouter J de Jonge & Reina E Mebius (Source: Nature Immunology)
Source: Nature Immunology - September 26, 2009 Category: Allergy & Immunology Authors: Serge A van de PavertBrenda J OlivierGera GoverseMark F VondenhoffMascha GreuterPatrick BekeKim KusserUta E HöpkenMartin LippKaren NiederreitherRune BlomhoffKasia SitnikWilliam W AgaceTroy D RandallWouter J de JongeReina E Mebius Tags: Article Source Type: journals
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal
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Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal
Nature Immunology 10, 1185 (2009). doi:10.1038/ni.1790
Authors: Brian T Fife, Kristen E Pauken, Todd N Eagar, Takashi Obu, Jenny Wu, Qizhi Tang, Miyuki Azuma, Matthew F Krummel & Jeffrey A Bluestone (Source: Nature Immunology)
Source: Nature Immunology - September 26, 2009 Category: Allergy & Immunology Authors: Brian T FifeKristen E PaukenTodd N EagarTakashi ObuJenny WuQizhi TangMiyuki AzumaMatthew F KrummelJeffrey A Bluestone Tags: Article Source Type: journals
Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
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chell Kronenberg (Source: Nature Immunology)
Source: Nature Immunology - September 26, 2009 Category: Allergy & Immunology Authors: Masako MuraiOlga TurovskayaGisen KimRajat MadanChristopher L KarpHilde CheroutreMitchell Kronenberg Tags: Article Source Type: journals
Research Highlights
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Nature Immunology 10, 1055 (2009). doi:10.1038/ni1009-1055 (Source: Nature Immunology)
Source: Nature Immunology - September 24, 2009 Category: Allergy & Immunology Tags: Research Highlights Source Type: journals
Beyond peptidoglycan for Nod2
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Nature Immunology 10, 1053 (2009). doi:10.1038/ni1009-1053
Author: Peter J Murray
Nod2 is a cytoplasmic Nod-like receptor protein that detects the peptidoglycan subfragment muramyl dipeptide. New work shows that Nod2 also has an important role in recognizing viruses and in triggering interferon production during viral infection. (Source: Nature Immunology)
Source: Nature Immunology - September 24, 2009 Category: Allergy & Immunology Authors: Peter J Murray Tags: News and Views Source Type: journals
A defining factor for natural killer cell development
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Nature Immunology 10, 1051 (2009). doi:10.1038/ni1009-1051
Author: James P Di Santo
Transcription factors are critical regulators of cell fate in the hemato-lymphoid system. New evidence indicates that the basic leucine zipper transcription factor E4BP4 (also known as NFIL3) is essential for natural killer cell specification. (Source: Nature Immunology)
Source: Nature Immunology - September 24, 2009 Category: Allergy & Immunology Authors: James P Di Santo Tags: News and Views Source Type: journals
New DNA-sensing pathway feeds RIG-I with RNA
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Nature Immunology 10, 1049 (2009). doi:10.1038/ni1009-1049
Author: Xuetao Cao
Cytosolic DNA sensors have remained poorly defined so far. Two recent studies identify a previously undefined cytosolic DNA-sensing pathway that depends on the RNA polymerase III–mediated conversion of microbial DNA into 5′-triphosphate double-stranded RNA that activates the RNA helicase RIG-I. (Source: Nature Immunology)
Source: Nature Immunology - September 24, 2009 Category: Allergy & Immunology Authors: Xuetao Cao Tags: News and Views Source Type: journals
The importance of being earnestly selfish
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Lambolez
Agonist encounter can divert thymocytes into several unconventional T cell subsets, many of which exhibit regulatory properties. Unexpected findings indicate that agonist selection can drive the differentiation of interleukin 17–producing cells in the thymus. (Source: Nature Immunology)
Source: Nature Immunology - September 24, 2009 Category: Allergy & Immunology Authors: Hilde CheroutreDaniel MucidaFlorence Lambolez Tags: News and Views Source Type: journals
The immune system as an invisible, silent Grand Fugue
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rrelly
The Science Gallery, Trinity College Dublin, recently held an exhibition called “INFECTIOUS: STAY AWAY” that used art to illustrate infection and immunity. Luke O'Neill talks to one of the artists, Gordana Novakovic, about her involvement in this project. (Source: Nature Immunology)
Source: Nature Immunology - September 24, 2009 Category: Allergy & Immunology Authors: Luke A J O'NeillCliona O'Farrelly Tags: Commentary Source Type: journals
Renaissance for mouse models of human hematopoiesis and immunobiology
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Santo
More than 20 years after the first successful engraftment of human leukocytes and hematopoietic organs in mice, scientists met for the 2nd International Workshop on Humanized Mice to discuss progress and to highlight expectations in this dynamic field. (Source: Nature Immunology)
Source: Nature Immunology - September 24, 2009 Category: Allergy & Immunology Authors: Markus G ManzJames P Di Santo Tags: Meeting Report Source Type: journals
Knighting immunology
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Nature Immunology 10, 1037 (2009). doi:10.1038/ni1009-1037
Author: Stefan H E Kaufmann (Source: Nature Immunology)
Source: Nature Immunology - September 24, 2009 Category: Allergy & Immunology Authors: Stefan H E Kaufmann Tags: Correspondence Source Type: journals
A long way to go...
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Nature Immunology 10, 1035 (2009). doi:10.1038/ni1009-1035
Federal policy on human embryonic stem cell research must become bolder to truly support progress in the field. (Source: Nature Immunology)
Source: Nature Immunology - September 24, 2009 Category: Allergy & Immunology Tags: Editorial Source Type: journals
Corrigendum: RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci
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Nature Immunology 10, 1034 (2009). doi:10.1038/ni0909-1034
Author: Susannah L Hewitt, Bu Yin, Yanhong Ji, Julie Chaumeil, Katarzyna Marszalek, Jeannette Tenthorey, Giorgia Salvagiotto, Natalie Steinel, Laura B Ramsey, Jacques Ghysdael, Michael A Farrar, Barry P Sleckman, David G Schatz, Meinrad Busslinger, Craig H Bassing & Jane A Skok (Source: Nature Immunology)
Source: Nature Immunology - September 22, 2009 Category: Allergy & Immunology Authors: Susannah L HewittBu YinYanhong JiJulie ChaumeilKatarzyna MarszalekJeannette TenthoreyGiorgia SalvagiottoNatalie SteinelLaura B RamseyJacques GhysdaelMichael A FarrarBarry P SleckmanDavid G SchatzMeinrad BusslingerCraig H BassingJane A Skok Tags: Corrigendum Source Type: journals
Research Highlights
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Nature Immunology 10, 941 (2009). doi:10.1038/ni0909-941 (Source: Nature Immunology)
Source: Nature Immunology - September 22, 2009 Category: Allergy & Immunology Tags: Research Highlights Source Type: journals
Regulatory T cells that become autoaggressive
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lavell
Foxp3 expression is not stable and may be extinguished both in vitro and in vivo in regulatory T cells that convert into proinflammatory effector T cells. The loss of Foxp3 in regulatory T cells under autoimmune conditions may result in the conversion of suppressor T cells into highly autoaggressive lymphocytes. (Source: Nature Immunology)
Source: Nature Immunology - September 22, 2009 Category: Allergy & Immunology Authors: Daniel HawigerRichard A Flavell Tags: News and Views Source Type: journals
Maintaining immune homeostasis in fly gut
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lien Royet
Like every metazoan species hosting a gut flora, drosophila tolerate commensal microbiota yet remain able to mount an efficient immune response to food-borne pathogens. New findings explain how the quantity of reactive oxygen species in the gut is 'tuned' to microbial burden and how intestinal immune homeostasis is thereby maintained. (Source: Nature Immunology)
Source: Nature Immunology - September 22, 2009 Category: Allergy & Immunology Authors: François LeulierJulien Royet Tags: News and Views Source Type: journals
The sickness unto Deaf
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derson
While promiscuous expression of tissue-specific antigens (TSAs) in the thymus is essential for self-tolerance, immunologically relevant TSA expression may also occur in the secondary lymphoid organs. A new study links the transcriptional regulator Deaf1 with altered TSA expression in the secondary lymphoid organs and autoimmune diabetes. (Source: Nature Immunology)
Source: Nature Immunology - September 22, 2009 Category: Allergy & Immunology Authors: James M GardnerMark S Anderson Tags: News and Views Source Type: journals
Intrusive HIV-1-infected cells
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hwartz
Macrophages infected with human immunodeficiency virus type 1 emit long intercellular conduits that shuttle the viral protein Nef to bystander B cells, where it impairs cellular function and immunoglobulin class switching. (Source: Nature Immunology)
Source: Nature Immunology - September 22, 2009 Category: Allergy & Immunology Authors: Dominika RudnickaOlivier Schwartz Tags: News and Views Source Type: journals
From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce TH1 development
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Murphy (Source: Nature Immunology)
Source: Nature Immunology - September 22, 2009 Category: Allergy & Immunology Authors: Anne O'GarraKenneth M Murphy Tags: Essay Source Type: journals
Encouraging minority scientists
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Nature Immunology 10, 927 (2009). doi:10.1038/ni0909-927
The research community needs to increase the number of minority students who choose scientific research careers. (Source: Nature Immunology)
Source: Nature Immunology - September 22, 2009 Category: Allergy & Immunology Tags: Editorial Source Type: journals
CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex
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amp; Xin Lin (Source: Nature Immunology)
Source: Nature Immunology - September 19, 2009 Category: Allergy & Immunology Authors: Weihui WuYen-Michael S HsuLiangkuan BiZhou SongyangXin Lin Tags: Article Source Type: journals
Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells
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Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells
Nature Immunology 10, 1170 (2009). doi:10.1038/ni.1795
Authors: Dipayan Rudra, Takeshi Egawa, Mark M W Chong, Piper Treuting, Dan R Littman & Alexander Y Rudensky (Source: Nature Immunology)
Source: Nature Immunology - September 19, 2009 Category: Allergy & Immunology Authors: Dipayan RudraTakeshi EgawaMark M W ChongPiper TreutingDan R LittmanAlexander Y Rudensky Tags: Article Source Type: journals
Research Highlights
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Nature Immunology 10, 1055 (2009). doi:10.1038/ni1009-1055 (Source: Nature Immunology)
Source: Nature Immunology - September 18, 2009 Category: Allergy & Immunology Tags: Research Highlights Source Type: journals
