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Corrigendum: Baseline Ad5 serostatus does not predict Ad5 HIV vaccine–induced expansion of adenovirus-specific CD4+ T cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Corrigendum: Baseline Ad5 serostatus does not predict Ad5 HIV vaccine–induced expansion of adenovirus-specific CD4+ T cells Nature Medicine 15, 1333 (2009). doi:10.1038/nm1109-1333b Authors: Natalie A Hutnick, Diane G Carnathan, Sheri A Dubey, George Makedonas, Kara S Cox, Lisa Kierstead, Sarah J Ratcliffe, Michael N Robertson, Danilo R Casimiro, Hildegund C J Ertl & Michael R Betts (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Natalie A HutnickDiane G CarnathanSheri A DubeyGeorge MakedonasKara S CoxLisa KiersteadSarah J RatcliffeMichael N RobertsonDanilo R CasimiroHildegund C J ErtlMichael R Betts Tags: Corrigendum Source Type: journals

Erratum: A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
pher J Kirk & Marcus Groettrup (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Tony MuchamuelMichael BaslerMonette A AujayErika SuzukiKhalid W KalimChristoph LauerCatherine SylvainEileen R RingJamie ShieldsJing JiangPeter ShwonekFrancesco ParlatiSusan D DemoMark K BennettChristopher J KirkMarcus Groettrup Tags: Erratum Source Type: journals

Research HighlightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1256 (2009). doi:10.1038/nm1109-1256 (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Tags: Research Highlights Source Type: journals

Attacking the flu: New prospects for the rational design of antiviralsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ía-Sastre (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Estanislao Nistal-VillánAdolfo García-Sastre Tags: Between Bedside and Bench Source Type: journals

Attacking the flu: Neutralizing antibodies may lead to 'universal' vaccineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
bbarao Flu remains a major killer because of imperfect vaccines and widespread resistance to existing antivirals—problems particularly acute during a pandemic. New findings at the bedside and at the bench could lead to improvements on both fronts. Grace Chen and Kanta Subbarao discuss the implications of research identifying human antibodies than can neutralize a range of viral subtypes. The findings may help lead to a 'universal' vaccine against these diverse and rapidly evolving viruses. Estanislao Nistal-Villán and Adolfo García-Sastre examine two recent studies that reveal the crystal structure of a pro...
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Grace L ChenKanta Subbarao Tags: Between Bedside and Bench Source Type: journals

Drug may put brakes on Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1250 (2009). doi:10.1038/nm1109-1250 (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Tags: Community Corner Source Type: journals

Eye vessels saved by rescuing their pericyte partnersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1248 (2009). doi:10.1038/nm1109-1248 Author: David Antonetti High blood sugar can lead to diabetic retinopathy and subsequent blindness. Glucose is now found to quench a growth factor that keeps pericytes alive. Without these key support cells, the retinal vasculature degenerates (pages 1298–1306). (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: David Antonetti Tags: News and Views Source Type: journals

Autoimmunity: apoptotic fats grease transcriptionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1246 (2009). doi:10.1038/nm1109-1246 Author: Keith B Elkon Transcription factors known for handling the body's response to lipids promote clearance of apoptotic cells by macrophages, according to new research (pages 1266–1272). When this process goes awry, autoimmunity can result. (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Keith B Elkon Tags: News and Views Source Type: journals

Sepsis: the dark side of histonesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
linsky Injection of activated protein C (APC) is the last resort to rescue a patient with severe sepsis. Research into how APC works reveals that the drug inactivates histones (pages 1318–1321), which are toxic during severe sepsis. (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Catherine ChaputArturo Zychlinsky Tags: News and Views Source Type: journals

Rock the cradleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1244 (2009). doi:10.1038/nm1109-1244 Author: Teresa K Woodruff (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Teresa K Woodruff Tags: Book Review Source Type: journals

Prometheus v. Mayo case in the spotlightEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1243 (2009). doi:10.1038/nm1109-1243b Author: Lauren Cahoon (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Lauren Cahoon Tags: News Source Type: journals

Pharma positions to survive the impending patent cliffEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1243 (2009). doi:10.1038/nm1109-1243a Author: Mike May (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Mike May Tags: News Source Type: journals

Online resource aims to smooth the biomed patent searchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1242 (2009). doi:10.1038/nm1109-1242b Author: Simon Grose (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Simon Grose Tags: News Source Type: journals

Biosimilars legislation awakens data exclusivity debateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1242 (2009). doi:10.1038/nm1109-1242a Author: Stu Hutson (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Stu Hutson Tags: News Source Type: journals

'Machine or transformation test' put to the test itselfEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1241 (2009). doi:10.1038/nm1109-1241 Author: Mike May (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Mike May Tags: News Source Type: journals

Researchers ponder a patent-free worldEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1240 (2009). doi:10.1038/nm1109-1240b Author: Lauren Cahoon (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Lauren Cahoon Tags: News Source Type: journals

Pharma 'patent trolls' remain mostly the stuff of mythEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1240 (2009). doi:10.1038/nm1109-1240a Author: Stu Hutson (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Stu Hutson Tags: News Source Type: journals

Sluggish generics entry prompts calls for European patent reformEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1239 (2009). doi:10.1038/nm1109-1239b Author: Lucas Laursen (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Lucas Laursen Tags: News Source Type: journals

Biomedical patents: Overturning preconceptionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1239 (2009). doi:10.1038/nm1109-1239a (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Tags: News Source Type: journals

In debate over AIDS vaccine success, every detail countsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1238 (2009). doi:10.1038/nm1109-1238b Author: Roxanne Khamsi (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Roxanne Khamsi Tags: News Source Type: journals

Australian committees set to advise on translational medicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1238 (2009). doi:10.1038/nm1109-1238a Author: Simon Grose (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Simon Grose Tags: News Source Type: journals

Straight talk with...Joan ScottEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1236 (2009). doi:10.1038/nm1109-1236 Author: Genevive Bjorn (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Genevive Bjorn Tags: News Source Type: journals

News in briefEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1234 (2009). doi:10.1038/nm1109-1234 (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Tags: News Source Type: journals

Researchers come together to study natural HIV resistanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1233 (2009). doi:10.1038/nm1109-1233 Author: Cassandra Willyard (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Cassandra Willyard Tags: News Source Type: journals

Efforts to improve vaccine stabilization heat upEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1232 (2009). doi:10.1038/nm1109-1232 Author: Meredith Wadman (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Meredith Wadman Tags: News Source Type: journals

Wireless medical devices advance, weather balloons asideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1231 (2009). doi:10.1038/nm1109-1231 Author: Jon Evans (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Jon Evans Tags: News Source Type: journals

Patently naiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1229 (2009). doi:10.1038/nm1109-1229 Intellectual-property protection is a key driver of innovation, and researchers are always keen to file patents to shield their discoveries. Yet scientists often have an uninformed view of the value of their intellectual property. This naiveté slows down translational research. (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Tags: Editorial Source Type: journals

Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy Nature Medicine 15, 1298 (2009). doi:10.1038/nm.2052 Authors: Pedro Geraldes, Junko Hiraoka-Yamamoto, Motonobu Matsumoto, Allen Clermont, Michael Leitges, Andre Marette, Lloyd P Aiello, Timothy S Kern & George L King (Source: Nature Medicine)
Source: Nature Medicine - November 1, 2009 Category: Journals (General) Authors: Pedro GeraldesJunko Hiraoka-YamamotoMotonobu MatsumotoAllen ClermontMichael LeitgesAndre MaretteLloyd P AielloTimothy S KernGeorge L King Tags: Article Source Type: journals

Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nürnberg, Heribert Schunkert, Hugo A Katus & Wolfgang Rottbauer (Source: Nature Medicine)
Source: Nature Medicine - November 1, 2009 Category: Journals (General) Authors: David HasselTillman DahmeJeanette ErdmannBenjamin MederAndreas HugeMonika StollSteffen JustAlexander HessPhilipp EhlermannDieter WeichenhanMatthias GrimmlerHenrike LiptauRoland HetzerVera Regitz-ZagrosekChristine FischerPeter NürnbergHeribert SchunkertHu Tags: Article Source Type: journals

Extracellular histones are major mediators of death in sepsisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& Charles T Esmon (Source: Nature Medicine)
Source: Nature Medicine - October 25, 2009 Category: Journals (General) Authors: Jun XuXiaomei ZhangRosana PelayoMarc MonestierConcetta T AmmolloFabrizio SemeraroFletcher B TaylorNaomi L EsmonFlorea LupuCharles T Esmon Tags: Letter Source Type: journals

Inhibition of the histone demethylase LSD1 blocks α-herpesvirus lytic replication and reactivation from latencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inhibition of the histone demethylase LSD1 blocks α-herpesvirus lytic replication and reactivation from latency Nature Medicine 15, 1312 (2009). doi:10.1038/nm.2051 Authors: Yu Liang, Jodi L Vogel, Aarthi Narayanan, Hua Peng & Thomas M Kristie (Source: Nature Medicine)
Source: Nature Medicine - October 25, 2009 Category: Journals (General) Authors: Yu LiangJodi L VogelAarthi NarayananHua PengThomas M Kristie Tags: Letter Source Type: journals

Notch3 signaling promotes the development of pulmonary arterial hypertensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ricia A Thistlethwaite (Source: Nature Medicine)
Source: Nature Medicine - October 25, 2009 Category: Journals (General) Authors: Xiaodong LiXiaoxue ZhangRobin LeathersAyako MakinoChengqun HuangPouria ParsaJesus MaciasJason X-J YuanStuart W JamiesonPatricia A Thistlethwaite Tags: Article Source Type: journals

Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
braham (Source: Nature Medicine)
Source: Nature Medicine - October 25, 2009 Category: Journals (General) Authors: Ashley L St JohnSoman N Abraham Tags: Article Source Type: journals

Foxo1 integrates insulin signaling with mitochondrial function in the liverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& Morris F White (Source: Nature Medicine)
Source: Nature Medicine - October 18, 2009 Category: Journals (General) Authors: Zhiyong ChengShaodong GuoKyle CoppsXiaochen DongRamya KolliparaJoseph T RodgersRonald A DepinhoPere PuigserverMorris F White Tags: Letter Source Type: journals

PPAR-δ senses and orchestrates clearance of apoptotic cells to promote toleranceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance Nature Medicine 15, 1266 (2009). doi:10.1038/nm.2048 Authors: Lata Mukundan, Justin I Odegaard, Christine R Morel, Jose E Heredia, Julia W Mwangi, Roberto R Ricardo-Gonzalez, Y P Sharon Goh, Alex Red Eagle, Shannon E Dunn, Jennifer U H Awakuni, Khoa D Nguyen, Lawrence Steinman, Sara A Michie & Ajay Chawla (Source: Nature Medicine)
Source: Nature Medicine - October 18, 2009 Category: Journals (General) Authors: Lata MukundanJustin I OdegaardChristine R MorelJose E HerediaJulia W MwangiRoberto R Ricardo-GonzalezY P Sharon GohAlex Red EagleShannon E DunnJennifer U H AwakuniKhoa D NguyenLawrence SteinmanSara A MichieAjay Chawla Tags: Article Source Type: journals

Matrix-insensitive protein assays push the limits of biosensors in medicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ambhir & Shan X Wang (Source: Nature Medicine)
Source: Nature Medicine - October 11, 2009 Category: Journals (General) Authors: Richard S GasterDrew A HallCarsten H NielsenSebastian J OsterfeldHeng YuKathleen E MachRobert J WilsonBoris MurmannJoseph C LiaoSanjiv S GambhirShan X Wang Tags: Technical Report Source Type: journals

Major histocompatibility complex genotyping with massively parallel pyrosequencingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Harkins & David H O'Connor (Source: Nature Medicine)
Source: Nature Medicine - October 11, 2009 Category: Journals (General) Authors: Roger W WisemanJulie A KarlBenjamin N BimberClaire E O'LearySimon M LankJennifer J TuscherAnn M DetmerPascal BouffardNatalya LevenkovaCynthia L TurcotteEdward SzekeresChris WrightTimothy HarkinsDavid H O'Connor Tags: Technical Report Source Type: journals

Shifting paradigms: the seeds of oncogene addictionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1158 (2009). doi:10.1038/nm1009-1158 Author: Charles L Sawyers (Source: Nature Medicine)
Source: Nature Medicine - October 8, 2009 Category: Journals (General) Authors: Charles L Sawyers Tags: Commentary Source Type: journals

Attacking cancer at its foundationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1153 (2009). doi:10.1038/nm1009-1153 Author: Nicholas Lydon (Source: Nature Medicine)
Source: Nature Medicine - October 8, 2009 Category: Journals (General) Authors: Nicholas Lydon Tags: Commentary Source Type: journals

Perspectives on the development of imatinib and the future of cancer researchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1149 (2009). doi:10.1038/nm1009-1149 Author: Brian J Druker (Source: Nature Medicine)
Source: Nature Medicine - October 8, 2009 Category: Journals (General) Authors: Brian J Druker Tags: Commentary Source Type: journals

Ekiden to iPS CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1145 (2009). doi:10.1038/nm1009-1145 Author: Shinya Yamanaka (Source: Nature Medicine)
Source: Nature Medicine - October 8, 2009 Category: Journals (General) Authors: Shinya Yamanaka Tags: Commentary Source Type: journals

Nuclear reprogramming in eggsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1141 (2009). doi:10.1038/nm1009-1141 Author: John Gurdon (Source: Nature Medicine)
Source: Nature Medicine - October 8, 2009 Category: Journals (General) Authors: John Gurdon Tags: Commentary Source Type: journals

Lasker Awards and papal portraiture: turning fields upside downEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1137 (2009). doi:10.1038/nm1009-1137 Author: Joseph L Goldstein (Source: Nature Medicine)
Source: Nature Medicine - October 8, 2009 Category: Journals (General) Authors: Joseph L Goldstein Tags: Commentary Source Type: journals

Research HighlightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1134 (2009). doi:10.1038/nm1009-1134 (Source: Nature Medicine)
Source: Nature Medicine - October 8, 2009 Category: Journals (General) Tags: Research Highlights Source Type: journals

Bleeding in the brain: Amyloid-β may keep clots awayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bleeding in the brain: Amyloid-β may keep clots away Nature Medicine 15, 1132 (2009). doi:10.1038/nm1009-1132 Author: Gregory J del Zoppo (Source: Nature Medicine)
Source: Nature Medicine - October 8, 2009 Category: Journals (General) Authors: Gregory J del Zoppo Tags: Between Bedside and Bench Source Type: journals

Bleeding in the brain: Killer waves of depolarization in subarachnoid bleedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1131 (2009). doi:10.1038/nm1009-1131 Author: Costantino Iadecola Hemorrhages in the brain are responsible for about 15% of strokes and are particularly difficult to treat. Costantino Iadecola assesses a new clinical study that may change the view of why a common form of hemorrhage, subarachnoid hemorrhage, often leads to death. Massive brain lesions often develop days after the initial event, a dangerous complication previously attributed to vasospasm, narrowing of the arteries. The study suggests that these lesions may instead by caused by neuronal depolarization, extending in waves across the brain...
Source: Nature Medicine - October 8, 2009 Category: Journals (General) Authors: Costantino Iadecola Tags: Between Bedside and Bench Source Type: journals

Biomarkers for Alzheimer's disease: the dilemma of silent diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1130 (2009). doi:10.1038/nm1009-1130 (Source: Nature Medicine)
Source: Nature Medicine - October 8, 2009 Category: Journals (General) Tags: Community Corner Source Type: journals

Gene copy number: learning to count past twoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A Kaslow The number of copies of the gene encoding a ligand for an HIV co-receptor have been found to influence the susceptibility to HIV infection and AIDS progression. New studies dispute this conclusion. The studies are contested by the authors of the original findings, and highlight the inherent difficulties in accurately measuring gene copy numbers (pages 1110–1112, 1112–1115, 1115–1117 and 1117–1120). (Source: Nature Medicine)
Source: Nature Medicine - October 8, 2009 Category: Journals (General) Authors: Sadeep ShresthaJianming TangRichard A Kaslow Tags: News and Views Source Type: journals

Epilepsy: synapses stuck in childhoodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1126 (2009). doi:10.1038/nm1009-1126 Author: Matteo Caleo Mouse experiments show how mutation of a gene involved in human epilepsy causes hyperexcitability of the neuronal network (pages 1208–1214). The mutations interfere with the maturation of excitatory synapses during postnatal development. (Source: Nature Medicine)
Source: Nature Medicine - October 8, 2009 Category: Journals (General) Authors: Matteo Caleo Tags: News and Views Source Type: journals

Preserving fertility during cancer treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Medicine 15, 1124 (2009). doi:10.1038/nm1009-1124 Author: Teresa K Woodruff Imatinib (trade name Gleevec) preserves fertility in female mice treated with the common chemotherapeutic agent cisplatin. Imatinib seems to block an apoptotic pathway activated by cisplatin in ovarian germ cells (pages 1179–1185). The findings could lead to new ways to protect germ cells from the damaging effects of cancer treatment. (Source: Nature Medicine)
Source: Nature Medicine - October 8, 2009 Category: Journals (General) Authors: Teresa K Woodruff Tags: News and Views Source Type: journals