Nature Neuroscience
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Amongst equals
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Nature Neuroscience 13, 151 (2010). doi:10.1038/nn0210-151
Author: Charvy Narain (Source: Nature Neuroscience)
Source: Nature Neuroscience - January 28, 2010 Category: Neuroscience Authors: Charvy Narain Tags: News and Views Source Type: journals
Shining a spotlight on headaches
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emy S H Taylor
Many headaches are worsened by light exposure. A new study uses a combination of human and rat experiments to suggest that a previously unknown retinal input to the thalamus may be important in such photophobia. (Source: Nature Neuroscience)
Source: Nature Neuroscience - January 28, 2010 Category: Neuroscience Authors: Zoltán MolnárJeremy S H Taylor Tags: News and Views Source Type: journals
Multisensory integration: an inner tongue puts an outer nose in context
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Sobel
By demonstrating that inactivation of gustatory cortex influences olfactory recognition, a new study finds that the interaction between taste and smell is bidirectional. (Source: Nature Neuroscience)
Source: Nature Neuroscience - January 28, 2010 Category: Neuroscience Authors: Yaara YeshurunNoam Sobel Tags: News and Views Source Type: journals
A 'sustain pedal' in the hippocampus?
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Kullmann
A study reveals that a largely ignored cell type in the dentate gyrus, semilunar granule cells, are persistently depolarized after a transient input and recruit interneurons to regulate the gating of information into the hippocampus. (Source: Nature Neuroscience)
Source: Nature Neuroscience - January 28, 2010 Category: Neuroscience Authors: Matthew C WalkerIvan PavlovDimitri M Kullmann Tags: News and Views Source Type: journals
A silver lining to stroke: does ischemia generate new cortical interneurons?
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oldman
New work identifies a latent population of neuronal progenitor cells in neocortical layer 1 of adult rats. These cells proliferate in response to forebrain ischemia, then integrate into the cortical network as interneurons. (Source: Nature Neuroscience)
Source: Nature Neuroscience - January 28, 2010 Category: Neuroscience Authors: Gord FishellJames E Goldman Tags: News and Views Source Type: journals
Renegade nuclear enzymes disrupt axonal integrity
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Nature Neuroscience 13, 143 (2010). doi:10.1038/nn0210-143
Author: Robert H Miller
How does axonal loss, a hallmark of multiple sclerosis, occur? A study in this issue implicates histone deacetylase 1 (HDAC1), better known for regulating DNA transcription, in such axon degeneration. HDAC1 is exported from the nucleus and interacts with motor proteins, blocking axonal transport and leading to axon loss. (Source: Nature Neuroscience)
Source: Nature Neuroscience - January 28, 2010 Category: Neuroscience Authors: Robert H Miller Tags: News and Views Source Type: journals
Ethical neuroscience
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Nature Neuroscience 13, 141 (2010). doi:10.1038/nn0210-141
Although institutional review boards are important ethical gatekeepers of human patient research, there is little data to evaluate their effectiveness. More coordination and a more transparent decision-making process is critical if review boards are to make appropriate and consistent decisions. (Source: Nature Neuroscience)
Source: Nature Neuroscience - January 28, 2010 Category: Neuroscience Tags: Editorial Source Type: journals
Activation of groups of excitatory neurons in the mammalian spinal cord or hindbrain evokes locomotion
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amp; Ole Kiehn (Source: Nature Neuroscience)
Source: Nature Neuroscience - January 17, 2010 Category: Neuroscience Authors: Martin HägglundLotta BorgiusKimberly J DoughertyOle Kiehn Tags: Article Source Type: journals
Glutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory map
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Karl Kandler (Source: Nature Neuroscience)
Source: Nature Neuroscience - January 17, 2010 Category: Neuroscience Authors: Jihyun NohRebecca P SealJessica A GarverRobert H EdwardsKarl Kandler Tags: Article Source Type: journals
Synaptic activation of kainate receptors gates presynaptic CB1 signaling at GABAergic synapses
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mp; Giovanni Marsicano (Source: Nature Neuroscience)
Source: Nature Neuroscience - January 17, 2010 Category: Neuroscience Authors: Joana LourençoAstrid CannichMario CartaFrançoise CoussenChristophe MulleGiovanni Marsicano Tags: Article Source Type: journals
A neural mechanism for exacerbation of headache by light
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p; Rami Burstein (Source: Nature Neuroscience)
Source: Nature Neuroscience - January 10, 2010 Category: Neuroscience Authors: Rodrigo NosedaVanessa KainzMoshe JakubowskiJoshua J GooleyClifford B SaperKathleen DigreRami Burstein Tags: Article Source Type: journals
Tsc2-Rheb signaling regulates EphA-mediated axon guidance
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uale & Mustafa Sahin (Source: Nature Neuroscience)
Source: Nature Neuroscience - January 10, 2010 Category: Neuroscience Authors: Duyu NieAlessia Di NardoJuliette M HanHasani BaharanyiIoannis KramvisThanhThao HuynhSandra DaboraSimone CodeluppiPier Paolo PandolfiElena B PasqualeMustafa Sahin Tags: Article Source Type: journals
The descending corticocollicular pathway mediates learning-induced auditory plasticity
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rew J King (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 27, 2009 Category: Neuroscience Authors: Victoria M BajoFernando R NodalDavid R MooreAndrew J King Tags: Article Source Type: journals
A single fear-inducing stimulus induces a transcription-dependent switch in synaptic AMPAR phenotype
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n & Siqiong June Liu (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 27, 2009 Category: Neuroscience Authors: Yu LiuLuigi FormisanoIaroslav SavtchoukYukihiro TakayasuGábor SzabóR Suzanne ZukinSiqiong June Liu Tags: Article Source Type: journals
Representing information in cell assemblies: persistent activity mediated by semilunar granule cells
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bridge (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 27, 2009 Category: Neuroscience Authors: Phillip LarimerBen W Strowbridge Tags: Article Source Type: journals
Amyloid beta from axons and dendrites reduces local spine number and plasticity
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oberto Malinow (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 27, 2009 Category: Neuroscience Authors: Wei WeiLouis N NguyenHelmut W KesselsHiroaki HagiwaraSangram SisodiaRoberto Malinow Tags: Article Source Type: journals
HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage
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atrizia Casaccia (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 27, 2009 Category: Neuroscience Authors: Jin Young KimSiming ShenKaren DietzYe HeOwain HowellRichard ReynoldsPatrizia Casaccia Tags: Article Source Type: journals
Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells
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i Kaneko & Shun Nakamura (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 27, 2009 Category: Neuroscience Authors: Koji OhiraTakahiro FurutaHiroyuki HiokiKouichi C NakamuraEriko KuramotoYasuyo TanakaNobuo FunatsuKeiko ShimizuTakao OishiMotoharu HayashiTsuyoshi MiyakawaTakeshi KanekoShun Nakamura Tags: Article Source Type: journals
Polar exploration
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Nature Neuroscience 13, 7 (2010). doi:10.1038/nn0110-7
Author: Jonathan D Wallis
The frontal pole cortex is thought to be the most complex of all frontal cortex areas. Overcoming technical obstacles to direct recordings, a study in this issue finds that neurons in this area have unexpectedly simple response properties. (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 24, 2009 Category: Neuroscience Authors: Jonathan D Wallis Tags: News and Views Source Type: journals
Sonic Hedgehog gets another role
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Nature Neuroscience 13, 6 (2010). doi:10.1038/nn0110-6
Author: Catherine E Krull
A study in this issue finds that the chemoattractant cue, Sonic Hedgehog, can activate a repulsive response of commissural axonal pathfinding to Semaphorins, thereby acting as a 'switch' in axon guidance. (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 24, 2009 Category: Neuroscience Authors: Catherine E Krull Tags: News and Views Source Type: journals
Ion pumps get more glamorous
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Nature Neuroscience 13, 4 (2010). doi:10.1038/nn0110-4
Author: David L Glanzman
A new study shows that the Na+/K+ ATPase can function as an integrator of spike activity and interacts with a K+ conductance to provide a cellular short-term memory of locomotion in the Drosophila larval motor circuit. (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 24, 2009 Category: Neuroscience Authors: David L Glanzman Tags: News and Views Source Type: journals
Testing the glutamate hypothesis of schizophrenia
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Nature Neuroscience 13, 2 (2010). doi:10.1038/nn0110-2
Author: Joshua A Gordon
A study in this issue presents a new mouse model that directly tests the glutamate hypothesis of schizophrenia. The study reports that a decrease in NMDA receptor signaling during a particular developmental window in interneurons can induce cellular and behavioral changes similar to those seen in schizophrenia. (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 24, 2009 Category: Neuroscience Authors: Joshua A Gordon Tags: News and Views Source Type: journals
Lagging laws
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Nature Neuroscience 13, 1 (2010). doi:10.1038/nn0110-01
The validity of a 1999 German patent on the derivation of neural precursors from human embryonic stem cells remains undecided, highlighting the inadequacy of European law for dealing with stem cell technology. (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 24, 2009 Category: Neuroscience Tags: Editorial Source Type: journals
Inactivation of primate superior colliculus impairs covert selection of signals for perceptual judgments
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auzlis (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 20, 2009 Category: Neuroscience Authors: Lee P LovejoyRichard J Krauzlis Tags: Article Source Type: journals
Control of hippocampal gamma oscillation frequency by tonic inhibition and excitation of interneurons
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n Mody (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 20, 2009 Category: Neuroscience Authors: Edward O MannIstvan Mody Tags: Article Source Type: journals
Activity in the amygdala elicited by unfair divisions predicts social value orientation
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Frith
'Social value orientation' characterizes individual differences in anchoring attitudes toward the division of resources. Here, by contrasting people with prosocial and individualistic orientations using functional magnetic resonance imaging, we demonstrate that degree of inequity aversion in prosocials is predictable from amygdala activity and unaffected by cognitive load. This result suggests that automatic emotional processing in the amygdala lies at the core of prosocial value orientation. (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 20, 2009 Category: Neuroscience Authors: Masahiko HarunoChristopher D Frith Tags: Brief Communication Source Type: journals
State dependence of olfactory perception as a function of taste cortical inactivation
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onald B Katz
As anyone who has suffered through a head cold knows, food eaten when the olfactory system is impaired tastes 'wrong', an experience that leads many to conclude that taste stimuli are processed normally only when the olfactory system is unimpaired. Evidence that the taste system influences olfactory perception, however, has been vanishingly rare. We found just such an influence; if taste cortex was inactivated when an odor was first presented, later presentations were properly appreciated only if taste cortex was again inactivated. (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 20, 2009 Category: Neuroscience Authors: Yaihara Fortis-SantiagoBenjamin A RodwinSelin NeselilerCaitlin E PietteDonald B Katz Tags: Brief Communication Source Type: journals
The relationship between visual resolution and cone spacing in the human fovea
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Roorda
Visual resolution decreases rapidly outside of the foveal center. The anatomical and physiological basis for this reduction is unclear. We used simultaneous adaptive optics imaging and psychophysical testing to measure cone spacing and resolution across the fovea, and found that resolution was limited by cone spacing only at the foveal center. Immediately outside of the center, resolution was worse than cone spacing predicted and better matched the sampling limit of midget retinal ganglion cells. (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 20, 2009 Category: Neuroscience Authors: Ethan A RossiAustin Roorda Tags: Brief Communication Source Type: journals
Parallel pathways for vocal learning in basal ganglia of songbirds
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ltenau
The cortical nucleus LMAN (lateral magnocellular nucleus of the anterior nidopallium) provides the output of a basal ganglia pathway that is necessary for vocal learning in juvenile songbirds. The shell subregion of LMAN (LMANshell) gives rise to recurrent loops that may subserve specific learning-related functions. We found that lesions in the LMANshell pathway caused no immediate disruption of vocal behavior, but prevented the development of stable vocal sequences and the ability to imitate vocal sounds. (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 20, 2009 Category: Neuroscience Authors: Sarah W BottjerBrie Altenau Tags: Brief Communication Source Type: journals
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
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S Lein & Hongkui Zeng (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 20, 2009 Category: Neuroscience Authors: Linda MadisenTheresa A ZwingmanSusan M SunkinSeung Wook OhHatim A ZariwalaHong GuLydia L NgRichard D PalmiterMichael J HawrylyczAllan R JonesEd S LeinHongkui Zeng Tags: Resource Source Type: journals
An in vivo biosensor for neurotransmitter release and in situ receptor activity
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David Kleinfeld (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 13, 2009 Category: Neuroscience Authors: Quoc-Thang NguyenLee F SchroederMarco MankArnaud MullerPalmer TaylorOliver GriesbeckDavid Kleinfeld Tags: Technical Report Source Type: journals
Synaptic computation underlying probabilistic inference
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g Wang (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 13, 2009 Category: Neuroscience Authors: Alireza SoltaniXiao-Jing Wang Tags: Article Source Type: journals
Rewiring of hindlimb corticospinal neurons after spinal cord injury
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er & Martin E Schwab (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 13, 2009 Category: Neuroscience Authors: Arko GhoshFlorent HaissEsther SydekumRegula SchneiderMiriam GulloMatthias T WyssThomas MuegglerChristof BaltesMarkus RudinBruno WeberMartin E Schwab Tags: Article Source Type: journals
SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker
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l & Kyunghee Koh (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 13, 2009 Category: Neuroscience Authors: Mark N WuWilliam J JoinerTerry DeanZhifeng YueCorinne J SmithDechun ChenToshinori HoshiAmita SehgalKyunghee Koh Tags: Article Source Type: journals
Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses
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lies Knipper & Walter Marcotti (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 13, 2009 Category: Neuroscience Authors: Stuart L JohnsonChristoph FranzStephanie KuhnDavid N FurnessLukas RüttigerStefan MünknerMarcelo N RivoltaElizabeth P SewardHarvey R HerschmanJutta EngelMarlies KnipperWalter Marcotti Tags: Article Source Type: journals
PIP3 controls synaptic function by maintaining AMPA receptor clustering at the postsynaptic membrane
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artens & José A Esteban (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 13, 2009 Category: Neuroscience Authors: Kristin L ArendtMaría RoyoMónica Fernández-MonrealShira KnafoCortney N PetrokJeffrey R MartensJosé A Esteban Tags: Article Source Type: journals
A small number of open Ca2+ channels trigger transmitter release at a central GABAergic synapse
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er Jonas
To determine the number of open Ca2+ channels necessary for transmitter release at the inhibitory basket cell–granule cell synapse in rat hippocampus, we combined presynaptic Ca2+ imaging, recording of postsynaptic currents and modeling. We found that that the opening of three or fewer Ca2+ channels triggered transmitter release. Furthermore, a small number of Ca2+ channels were able to evoke release with high temporal precision, despite stochastic Ca2+ channel opening. (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 13, 2009 Category: Neuroscience Authors: Iancu BucurenciuJosef BischofbergerPeter Jonas Tags: Brief Communication Source Type: journals
Evaluating self-generated decisions in frontal pole cortex of monkeys
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n P Wise (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 6, 2009 Category: Neuroscience Authors: Satoshi TsujimotoAldo GenovesioSteven P Wise Tags: Article Source Type: journals
Collective dynamics in human and monkey sensorimotor cortex: predicting single neuron spikes
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Donoghue (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 6, 2009 Category: Neuroscience Authors: Wilson TruccoloLeigh R HochbergJohn P Donoghue Tags: Article Source Type: journals
The corticothalamocortical circuit drives higher-order cortex in the mouse
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Sherman (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 6, 2009 Category: Neuroscience Authors: Brian B TheyelDaniel A LlanoS Murray Sherman Tags: Article Source Type: journals
Dissecting differential gene expression within the circadian neuronal circuit of Drosophila
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Michael Rosbash (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 6, 2009 Category: Neuroscience Authors: Emi NagoshiKen SuginoEla KulaEtsuko OkazakiTaro TachibanaSacha NelsonMichael Rosbash Tags: Article Source Type: journals
Spike integration and cellular memory in a rhythmic network from Na+/K+ pump current dynamics
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iffith (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 6, 2009 Category: Neuroscience Authors: Stefan R PulverLeslie C Griffith Tags: Article Source Type: journals
The slow (
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Hughes (Source: Nature Neuroscience)
Source: Nature Neuroscience - December 6, 2009 Category: Neuroscience Authors: Vincenzo CrunelliStuart W Hughes Tags: Review Source Type: journals
Intervening inhibition underlies simple-cell receptive field structure in visual cortex
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zhong Whit Tao (Source: Nature Neuroscience)
Source: Nature Neuroscience - November 29, 2009 Category: Neuroscience Authors: Bao-hua LiuPingyang LiYujiao J SunYa-tang LiLi I ZhangHuizhong Whit Tao Tags: Article Source Type: journals
Sonic hedgehog induces response of commissural axons to Semaphorin repulsion during midline crossing
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in Zou (Source: Nature Neuroscience)
Source: Nature Neuroscience - November 29, 2009 Category: Neuroscience Authors: Liseth M ParraYimin Zou Tags: Article Source Type: journals
Hippocampal theta rhythms follow the beat of their own drum
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Moser
The firing of most hippocampal neurons is modulated by the theta rhythm, but it's not clear how and where the rhythm is generated. A study now shows that the required machinery for theta generation lies in local circuits of the hippocampus. (Source: Nature Neuroscience)
Source: Nature Neuroscience - November 23, 2009 Category: Neuroscience Authors: Laura Lee ColginEdvard I Moser Tags: News and Views Source Type: journals
Pigment epithelium-derived growth factor: modulating adult neural stem cell self-renewal
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Weiss
The vascular niche-derived factor PEDF enhances Notch signaling in adult neural stem cells via an unexpected mechanism involving nuclear export of a transcriptional repressor, to promote both proliferation and multipotentiality. (Source: Nature Neuroscience)
Source: Nature Neuroscience - November 23, 2009 Category: Neuroscience Authors: Andrew ChojnackiSamuel Weiss Tags: News and Views Source Type: journals
Neuronal death or dismemberment mediated by Sox14
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reeman
The pruning of unneeded axons and dendrites is crucial for circuitry maturation, but poorly understood on the molecular level. During Drosophila metamorphosis, the transcription factor Sox14 acts as a context-dependent mediator of death, axonal or dendritic pruning. Its transcriptional target Mical acts specifically in dendrite pruning. (Source: Nature Neuroscience)
Source: Nature Neuroscience - November 23, 2009 Category: Neuroscience Authors: Jeannette M OsterlohMarc R Freeman Tags: News and Views Source Type: journals
Scientists talking to the public: is there anyone out there?
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Nature Neuroscience 12, 1477 (2009). doi:10.1038/nn1209-1477
Author: Dario L Ringach (Source: Nature Neuroscience)
Source: Nature Neuroscience - November 23, 2009 Category: Neuroscience Authors: Dario L Ringach Tags: Book Review Source Type: journals
Butting heads
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Nature Neuroscience 12, 1475 (2009). doi:10.1038/nn1209-1475
A recent controversy on sport-related dementia underscores the need for comprehensive epidemiology studies. (Source: Nature Neuroscience)
Source: Nature Neuroscience - November 23, 2009 Category: Neuroscience Tags: Editorial Source Type: journals
