Breast cancer: Obesity — tipping the scales of resistance
Nature Reviews Cancer 18, 265 (2018).
doi:10.1038/nrc.2018.31
Author: Conor A. Bradley
Using clinical tissue specimens and mouse models of breast cancer, Incio et al. show that obesity promotes the upregulation of interleukin-6 and fibroblast growth factor 2 in the tumour microenvironment, which confer resistance to anti-vascular endothelial growth factor therapy. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - April 6, 2018 Category: Cancer & Oncology Authors: Conor A. Bradley Tags: Research Highlight Source Type: research
Pancreatic cancer: The COMPASS shows the way
Nature Reviews Cancer 18, 373 (2018).
doi:10.1038/nrc.2018.29
Author: Sarah Seton-Rogers
Deregulation of the COMPASS-like complex, via loss of KDM6A in females and loss of both KDM6A and its Y chromosome homologue UTY in males, is important for activation of oncogene-associated super-enhancers and the development of pancreatic adenocarcinoma of the squamous subtype. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - April 3, 2018 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Breast cancer: External communication
Nature Reviews Cancer 18, 372 (2018).
doi:10.1038/nrc.2018.30
Author: Ulrike Harjes
In a new study, researchers show that basal-like breast cancer can be converted into the luminal subtype by inhibiting platelet-derived growth factor (PDGF)-CC signalling in the tumour microenvironment, thereby potentially broadening treatment options for oestrogen receptor-negative breast cancer patients. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - April 3, 2018 Category: Cancer & Oncology Authors: Ulrike Harjes Tags: Research Highlight Source Type: research
Leukaemia: Powers of prediction
Nature Reviews Cancer 18, 372 (2018).
doi:10.1038/nrc.2018.28
Author: Anna Dart
Good et al. use deep phenotypic single-cell analyses and machine learning to identify developmentally dependent cell signalling states in B cell precursor acute lymphoblastic leukaemia that are predictive of relapse. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - April 3, 2018 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Targeted therapy: Tipping the splicing balance to kill cancer cells
Nature Reviews Cancer 18, 209 (2018).
doi:10.1038/nrc.2018.27
Author: Megan Cully
A paper in Nature Medicine describes a novel, orally available splicing modulator that preferentially kills cancer cells with mutations in splicing factors in culture and in mouse models. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 22, 2018 Category: Cancer & Oncology Authors: Megan Cully Tags: Research Highlight Source Type: research
Immunotherapy: iPSC-based vaccines provoke a response
Nature Reviews Cancer 18, 207 (2018).
doi:10.1038/nrc.2018.26
Author: Sarah Seton-Rogers
Stem cells and cancer cells share some properties, which has led to the hypothesis that irradiated stem cells might be used as a vaccine for cancer treatment. Kooreman, Kim et al. tested this hypothesis using induced pluripotent stem cells (iPSCs). They first observed that both (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 22, 2018 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Metastasis: Go with the flow
Nature Reviews Cancer 18, 207 (2018).
doi:10.1038/nrc.2018.25
Author: Anna Dart
Medulloblastoma metastases almost always localize to the leptomeningeal surface of the brain and spinal cord, which has led to the assumption that the only mechanism of metastatic seeding is via dissemination of primary tumour cells into the cerebrospinal fluid and subsequent distal re-colonization of the (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 22, 2018 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Immunosurveillance: Presentation skills
Nature Reviews Cancer 18, 207 (2018).
doi:10.1038/nrc.2018.24
Author: Ulrike Harjes
Tumour-infiltrating CD8+ T cells are often located within stromal-rich areas in the tumour and thus are in close contact with cancer-associated fibroblasts (CAFs). New research by Lakins et al. shows that CAFs are able to inhibit tumour-antigen-specific T cell activity through engaging in (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 22, 2018 Category: Cancer & Oncology Authors: Ulrike Harjes Tags: Research Highlight Source Type: research
Immunotherapy: A therapeutic reservoir
Nature Reviews Cancer 18, 206 (2018).
doi:10.1038/nrc.2018.23
Author: Sarah Seton-Rogers
Wang, C., Wang, J. et al. show that local injection of a hydrogel scaffold degraded by reactive oxygen species in the tumour microenvironment releases chemotherapy and an immune checkpoint inhibitor with kinetics that increase antitumour responses. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 22, 2018 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Cell motility in cancer invasion and metastasis: insights from simple model organisms
Nature Reviews Cancer 18, 296 (2018).
doi:10.1038/nrc.2018.15
Authors: Christina H. Stuelten, Carole A. Parent & Denise J. Montell
Metastasis remains the greatest challenge in the clinical management of cancer. Cell motility is a fundamental and ancient cellular behaviour that contributes to metastasis and is conserved in simple organisms. In this Review, we evaluate insights relevant to human cancer that are derived from the (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 16, 2018 Category: Cancer & Oncology Authors: Christina H. Stuelten Carole A. Parent Denise J. Montell Tags: Review Source Type: research
Non-angiogenic tumours and their influence on cancer biology
Nature Reviews Cancer 18, 323 (2018).
doi:10.1038/nrc.2018.14
Authors: Tom Donnem, Andrew R. Reynolds, Elizabeth A. Kuczynski, Kevin Gatter, Peter B. Vermeulen, Robert S. Kerbel, Adrian L. Harris & Francesco Pezzella
Solid tumours need a blood supply, and a large body of evidence has previously suggested that they can grow only if they induce the development of new blood vessels, a process known as tumour angiogenesis. On the basis of this hypothesis, it was proposed that (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 9, 2018 Category: Cancer & Oncology Authors: Tom Donnem Andrew R. Reynolds Elizabeth A. Kuczynski Kevin Gatter Peter B. Vermeulen Robert S. Kerbel Adrian L. Harris Francesco Pezzella Tags: Perspectives Source Type: research
Epigenetics: Methylating patterns
Nature Reviews Cancer 18, 206 (2018).
doi:10.1038/nrc.2018.21
Author: Anna Dart
Xie et al. show that senescence-associated DNA methylation changes evolve independently of stochastic tumour-associated methylation changes and that a subset of commonly methylated genes with the highest gains are associated with early tumorigenesis and ageing. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 9, 2018 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Immunotherapy: Tear down this wall
Nature Reviews Cancer 18, 205 (2018).
doi:10.1038/nrc.2018.22
Author: Ulrike Harjes
Activation of TGFβ signalling in invasive margins of metastatic tumours can contribute to T cell exclusion and reduced immune checkpoint therapy response. Inhibition of TGFβ in non-responders can potentially help to improve outcomes in these patients. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 9, 2018 Category: Cancer & Oncology Authors: Ulrike Harjes Tags: Research Highlight Source Type: research
The molecular landscape of head and neck cancer
Nature Reviews Cancer 18, 269 (2018).
doi:10.1038/nrc.2018.11
Authors: C. René Leemans, Peter J. F. Snijders & Ruud H. Brakenhoff
Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal linings of the upper aerodigestive tract and are unexpectedly heterogeneous in nature. Classical risk factors are smoking and excessive alcohol consumption, and in recent years, the role of human papillomavirus (HPV) has emerged, particularly (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 2, 2018 Category: Cancer & Oncology Authors: C. Ren é Leemans Peter J. F. Snijders Ruud H. Brakenhoff Tags: Review Source Type: research
Opportunities and challenges for human papillomavirus vaccination in cancer
Nature Reviews Cancer 18, 240 (2018).
doi:10.1038/nrc.2018.13
Authors: Richard B. S. Roden & Peter L. Stern
The discovery of genotype 16 as the prototype oncogenic human papillomavirus (HPV) initiated a quarter century of laboratory and epidemiological studies that demonstrated their necessary, but not sufficient, aetiological role in cervical and several other anogenital and oropharyngeal cancers. Early virus-induced immune deviation can lead (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 2, 2018 Category: Cancer & Oncology Authors: Richard B. S. Roden Peter L. Stern Tags: Review Source Type: research
