Influenza virus: Choose your enemies wisely
Nature Reviews Immunology 18, 294 (2018).
doi:10.1038/nri.2018.30
Author: Yvonne Bordon
Natural influenza virus infection in humans induces protective neuraminidase-reactive antibodies that are not induced by current influenza vaccines. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 25, 2018 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
Adaptive immunity by convergent evolution
Nature Reviews Immunology 18, 294 (2018).
doi:10.1038/nri.2018.28
Author: Jean-Laurent Casanova
Jean-Laurent Casanova describes three papers by Max Cooper and colleagues that described the convergent evolution of adaptive immunity in jawless vertebrates. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 25, 2018 Category: Allergy & Immunology Authors: Jean-Laurent Casanova Tags: Research Highlight Source Type: research
Immunometabolism: Old drug, new trick
Nature Reviews Immunology 18, 295 (2018).
doi:10.1038/nri.2018.29
Author: Yvonne Bordon
The immunomodulatory drug dimethyl fumarate blocks GAPDH and aerobic glycolysis in activated immune cells. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 16, 2018 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
Immunometabolism: Itaconate helps KEAP1's cool
Nature Reviews Immunology 18, 294 (2018).
doi:10.1038/nri.2018.27
Author: Grant Otto
Itaconate alkylates KEAP1 to regulate NRF2 activity and induce an anti-inflammatory response in macrophages (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 9, 2018 Category: Allergy & Immunology Authors: Grant Otto Tags: Research Highlight Source Type: research
Discovering transcriptional signatures of disease for diagnosis versus mechanism
Nature Reviews Immunology 18, 289 (2018).
doi:10.1038/nri.2018.26
Authors: Julie G. Burel & Bjoern Peters
Transcriptional signatures of disease can be used for diagnosis or to gain insight into disease mechanisms. This Comment article discusses the different sets of criteria that should be considered for the optimal design of investigations addressing these two purposes, using examples from the study of tuberculosis. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 9, 2018 Category: Allergy & Immunology Authors: Julie G. Burel Bjoern Peters Tags: Comment Source Type: research
Allergy: An alarmin cut
Nature Reviews Immunology 18, 293 (2018).
doi:10.1038/nri.2018.23
Author: Lucy Bird
Proteolytic cleavage of IL-33 by environmental allergens induces rapid induction of allergic type 2 inflammation. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 4, 2018 Category: Allergy & Immunology Authors: Lucy Bird Tags: Research Highlight Source Type: research
Macrophages: Running on empty
Nature Reviews Immunology 18, 292 (2018).
doi:10.1038/nri.2018.25
Author: Yvonne Bordon
NRP1-deficient macrophages show impaired fatty acid oxidation. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 4, 2018 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
Germinal centres: An exit strategy for B cells
Nature Reviews Immunology 18, 292 (2018).
doi:10.1038/nri.2018.24
Author: Kirsty Minton
The ubiquitin ligase activity of CBL proteins controls the exit of B cells from the germinal centre to become plasma cells. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 4, 2018 Category: Allergy & Immunology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
Mucosal immunology: Glucose not good for the gut
Nature Reviews Immunology 18, 291 (2018).
doi:10.1038/nri.2018.22
Author: Kirsty Minton
Hyperglycaemia directly mediates dysfunction of the intestinal epithelial barrier in obesity, leading to increased translocation of microbial products. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - March 21, 2018 Category: Allergy & Immunology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
A novel genetic architecture of infectious diseases
Nature Reviews Immunology 18, 224 (2018).
doi:10.1038/nri.2018.19
Author: Laurent Abel
Laurent Abel describes two landmark studies from 1996 that described the genetic susceptibility of children to severe mycobacterial infections. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - March 16, 2018 Category: Allergy & Immunology Authors: Laurent Abel Tags: Research Highlight Source Type: research
Neuroimmunology: No pain, all gain
Nature Reviews Immunology 18, 222 (2018).
doi:10.1038/nri.2018.21
Author: Lucy Bird
Sensory neurons in the lungs suppress immune responses to bacterial lung infections. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - March 16, 2018 Category: Allergy & Immunology Authors: Lucy Bird Tags: Research Highlight Source Type: research
Immunotherapy: Tear down this wall
Nature Reviews Immunology 18, 221 (2018).
doi:10.1038/nri.2018.20
Author: Ulrike Harjes
Activation of TGFβ signalling in invasive margins of metastatic tumours can contribute to T cell exclusion and reduced immune checkpoint therapy response. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - March 16, 2018 Category: Allergy & Immunology Authors: Ulrike Harjes Tags: Research Highlight Source Type: research
Stem cells: Escape from the Jedi
Nature Reviews Immunology 18, 224 (2018).
doi:10.1038/nri.2018.18
Author: Grant Otto
Quiescent adult stem cells escape immune surveillance by downregulating the antigen presentation machinery. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - March 5, 2018 Category: Allergy & Immunology Authors: Grant Otto Tags: Research Highlight Source Type: research
Vaccines: Stem cell hope for cancer treatment
Nature Reviews Immunology 18, 223 (2018).
doi:10.1038/nri.2018.16
Author: Shimona Starling
An irradiated induced pluripotent stem cell-based vaccine induces cancer immunity in vivo. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - March 5, 2018 Category: Allergy & Immunology Authors: Shimona Starling Tags: Research Highlight Source Type: research
Antibodies: Septic shock absorbers
Nature Reviews Immunology 18, 222 (2018).
doi:10.1038/nri.2018.17
Author: Yvonne Bordon
Gut commensals induce systemic IgA responses that protect mice against lethal sepsis. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - March 5, 2018 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
