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Cell signalling: DNA damage puts p38 under the UV light
Nature Reviews Molecular Cell Biology 19, 279 (2018). doi:10.1038/nrm.2018.22 Author: Eytan Zlotorynski Ultraviolet radiation induces p38–MK2-dependent phosphorylation of NELFE, which causes its dissociation from chromatin and promotes transcription of damage-response genes. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - March 28, 2018 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research

Mechanotransduction: Kindlin' the fate of mesenchymal stem cells
Nature Reviews Molecular Cell Biology 19, 278 (2018). doi:10.1038/nrm.2018.21 Author: Kim Baumann Kindlin-2 controls mesenchymal stem cell differentiation in repsonse to matrix stiffness by regulting the levels and activity of YAP and TAZ. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - March 21, 2018 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research

Reprogramming: Methylation patterns in primordial germ cells
This study describes the molecular mechanisms underlying epigenetic reprogramming in primordial germ cells. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - March 21, 2018 Category: Cytology Authors: Katharine H. Wrighton Tags: Research Highlight Source Type: research

Stem cells: Translating hypertranscription in embryonic stem cells
Nature Reviews Molecular Cell Biology 19, 209 (2018). doi:10.1038/nrm.2018.19 Author: Kim Baumann The decondensed, permissive chromatin state of pluripotent stem cells is sensitive to translation, creating a positive feedback loop whereby hypertranscription depends on the high output of translation it produces. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - March 20, 2018 Category: Cytology Authors: Kim Baumann Tags: Research Highlight Source Type: research

Regeneration: Mending broken hearts
Nature Reviews Molecular Cell Biology 19, 277 (2018). doi:10.1038/nrm.2018.18 Author: Paulina Strzyz The polyploidy of mammalian cardiomyocytes is a barrier to heart regeneration, but modification of the cardiomyocyte cell cycle can boost their regenerative potential. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - March 7, 2018 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research

DNA Replication: Onco-agent provocateur
Nature Reviews Molecular Cell Biology 19, 211 (2018). doi:10.1038/nrm.2018.17 Author: Eytan Zlotorynski Oncogenes induce firing of replication origins at transcribed genes; this promotes transcription–replication conflicts and genome instability. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - March 7, 2018 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research

Autophagy: Mitochondria encaged
Nature Reviews Molecular Cell Biology 19, 212 (2018). doi:10.1038/nrm.2018.16 Author: Paulina Strzyz Myosin VI is recruited to ubiquitylated mitochondria and drives their encapsulation into actin cages to sequester them for mitophagy. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - February 28, 2018 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research

Metabolism: A metabolic switch of fate
Nature Reviews Molecular Cell Biology 19, 211 (2018). doi:10.1038/nrm.2018.14 Author: Paulina Strzyz Fatty acid oxidation and increased acetyl-CoA levels act to suppress endothelial–mesenchymal transition. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - February 21, 2018 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research

Gene expression: Developmental enhancers in action
Nature Reviews Molecular Cell Biology 19, 210 (2018). doi:10.1038/nrm.2018.15 Author: Eytan Zlotorynski Developmental enhancers can function in an additive manner and are regulated by RNA polymerase II pausing and by the directionality of transcription. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - February 21, 2018 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research

Chromosome biology: A stairway to mitotic chromosome assembly
Nature Reviews Molecular Cell Biology 19, 139 (2018). doi:10.1038/nrm.2018.13 Author: Paulina Strzyz Condensin complexes drive mitotic chromosome formation by structuring chromatin into nested loops and organizing them along a central, helical scaffold. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - February 20, 2018 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research

Mechanisms of clathrin-mediated endocytosis
Nature Reviews Molecular Cell Biology 19, 313 (2018). doi:10.1038/nrm.2017.132 Authors: Marko Kaksonen & Aurélien Roux Clathrin-mediated endocytosis is a key process in vesicular trafficking that transports a wide range of cargo molecules from the cell surface to the interior. Clathrin-mediated endocytosis was first described over 5 decades ago. Since its discovery, over 50 proteins have been shown to be part (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - February 7, 2018 Category: Cytology Authors: Marko Kaksonen Aur é lien Roux Tags: Review Source Type: research

Understanding the diversity of membrane lipid composition
Nature Reviews Molecular Cell Biology 19, 281 (2018). doi:10.1038/nrm.2017.138 Authors: Takeshi Harayama & Howard Riezman Cellular membranes are formed from a chemically diverse set of lipids present in various amounts and proportions. A high lipid diversity is universal in eukaryotes and is seen from the scale of a membrane leaflet to that of a whole organism, highlighting its importance and (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - February 7, 2018 Category: Cytology Authors: Takeshi Harayama Howard Riezman Tags: Review Source Type: research

Ubiquitin chains as second messengers
Nature Reviews Molecular Cell Biology 19, 212 (2018). doi:10.1038/nrm.2018.9 Author: Philip Cohen Philip Cohen highlights how two studies from the laboratory of Zhijian Chen, published in 2000 and 2001, started a new era in the study of signal transduction pathways and the roles of ubiquitin chains. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - February 7, 2018 Category: Cytology Authors: Philip Cohen Tags: Research Highlight Source Type: research

Stem cells: A balancing act of lipids
Nature Reviews Molecular Cell Biology 19, 141 (2018). doi:10.1038/nrm.2018.10 Author: Paulina Strzyz Perturbation of phospholipid composition in intestinal stem cells (ISCs) results in increased cholesterol biosynthesis; excess cholesterol is a driver of ISC hyperproliferation, and consequently of intestinal hypertrophy and cancer. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - February 7, 2018 Category: Cytology Authors: Paulina Strzyz Tags: Research Highlight Source Type: research

RNA metabolism: Interfering with interferon by RNA editing
Nature Reviews Molecular Cell Biology 19, 140 (2018). doi:10.1038/nrm.2018.12 Author: Eytan Zlotorynski By editing of endogenous mRNAs, the RNA editing enzyme ADAR1 prevents interferon-induced translation shutdown and cell death, and virus-independent interferon induction in neuronal cells. (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - February 7, 2018 Category: Cytology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research